Hi,
Thanks for your nice package and its extensive documentation :)
I am working with DNA Methylation data and wanted to use your package for some differential analysis of my experimental design. I was wondering what assumptions for the data I might have to look out for when NOT working with RNA-seq data, for which the package clearly was developed. Regular beta values are not distributed normally, but transforming them to M values will then fulfil this assumption.
I will be happy for any comments on this.
Best,
Alex
Hi,
Thanks for your nice package and its extensive documentation :)
I am working with DNA Methylation data and wanted to use your package for some differential analysis of my experimental design. I was wondering what assumptions for the data I might have to look out for when NOT working with RNA-seq data, for which the package clearly was developed. Regular beta values are not distributed normally, but transforming them to M values will then fulfil this assumption.
I will be happy for any comments on this.
Best,
Alex