diff --git a/src/components/Search/SearchAutocompleteInput.tsx b/src/components/Search/SearchAutocompleteInput.tsx
index 173644f175e56..186086b2ecc6b 100644
--- a/src/components/Search/SearchAutocompleteInput.tsx
+++ b/src/components/Search/SearchAutocompleteInput.tsx
@@ -73,7 +73,7 @@ type SearchAutocompleteInputProps = {
 
     /** Reference to the outer element */
     ref?: ForwardedRef<BaseTextInputRef>;
-} & Pick<TextInputProps, 'caretHidden' | 'autoFocus' | 'selection'>;
+} & Pick<TextInputProps, 'caretHidden' | 'autoFocus' | 'selection' | 'onKeyPress'>;
 
 function SearchAutocompleteInput({
     value,
@@ -94,6 +94,7 @@ function SearchAutocompleteInput({
     isSearchingForReports,
     selection,
     substitutionMap,
+    onKeyPress,
     ref,
 }: SearchAutocompleteInputProps) {
     const styles = useThemeStyles();
@@ -223,6 +224,7 @@ function SearchAutocompleteInput({
 
                             onBlur?.();
                         }}
+                        onKeyPress={onKeyPress}
                         isLoading={isSearchingForReports}
                         ref={(element) => {
                             if (!ref) {
diff --git a/src/components/Search/SearchPageHeader/SearchPageHeaderInput.tsx b/src/components/Search/SearchPageHeader/SearchPageHeaderInput.tsx
index 0eeaa34f1d2c2..d9cb68e267727 100644
--- a/src/components/Search/SearchPageHeader/SearchPageHeaderInput.tsx
+++ b/src/components/Search/SearchPageHeader/SearchPageHeaderInput.tsx
@@ -3,6 +3,7 @@ import {accountIDSelector} from '@selectors/Session';
 import {deepEqual} from 'fast-equals';
 import isEmpty from 'lodash/isEmpty';
 import React, {useCallback, useEffect, useMemo, useRef, useState} from 'react';
+import type {TextInputKeyPressEvent} from 'react-native';
 import {View} from 'react-native';
 import Animated from 'react-native-reanimated';
 import {usePersonalDetails} from '@components/OnyxListItemProvider';
@@ -131,6 +132,15 @@ function SearchPageHeaderInput({queryJSON, searchRouterListVisible, hideSearchRo
         // eslint-disable-next-line react-hooks/exhaustive-deps
     }, []);
 
+    const handleKeyPress = useCallback((e: TextInputKeyPressEvent) => {
+        const keyEvent = e as unknown as KeyboardEvent;
+
+        if (keyEvent.key === CONST.KEYBOARD_SHORTCUTS.ESCAPE.shortcutKey && textInputRef.current?.isFocused()) {
+            keyEvent.preventDefault();
+            textInputRef.current.blur();
+        }
+    }, []);
+
     const handleSearchAction = useCallback(
         (value: string) => {
             // Skip calling handleSearch on the initial mount
@@ -377,6 +387,7 @@ function SearchPageHeaderInput({queryJSON, searchRouterListVisible, hideSearchRo
                                 wrapperFocusedStyle={styles.searchAutocompleteInputResultsFocused}
                                 autocompleteListRef={listRef}
                                 ref={textInputRef}
+                                onKeyPress={handleKeyPress}
                             />
                         </Animated.View>
                         {showPopupButton && (
@@ -457,6 +468,7 @@ function SearchPageHeaderInput({queryJSON, searchRouterListVisible, hideSearchRo
                             ref={textInputRef}
                             selection={selection}
                             substitutionMap={autocompleteSubstitutions}
+                            onKeyPress={handleKeyPress}
                         />
                     </View>
                     {isAutocompleteListVisible && (