Can GRoSS be applied to polyploid data?

[WWz33]

Hi Dr.Fernando
I found that "diploid data" is mentioned in your article.
Can GRoSS be applied to polyploid data?

[FerRacimo]

Hi! GRoSS has a very simple data model for sampling. It assumes that, given the population allele frequency, then the allele counts you observe are a binomial sample from that allele frequency. So if you're ok with assuming that your polyploid data can be approximately modeled as such, then you can apply GRoSS to polyploid data as well. This would mean, for example, that you're ok with modelling a population sample of 8 tetraploid organisms as if they were 16 diploid organisms or 32 haploid organisms. Just make sure that the allele counts are correctly codified (e.g. if, at a given position, you have 8 tetraploid organisms, and you observe a total of 3 alternative alleles, then you have a total of 32 alleles, 3 of which are alternative and 29 of which are reference, so the counts should be "29,3").

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[WWz33]

Hi，
I got it.Thanks for your patience!