diff --git a/Seq_analysis/guideseq/guideseq/requirements.txt b/Seq_analysis/guideseq/guideseq/requirements.txt
index 4f3ff65..9287a18 100644
--- a/Seq_analysis/guideseq/guideseq/requirements.txt
+++ b/Seq_analysis/guideseq/guideseq/requirements.txt
@@ -1,5 +1,5 @@
 HTSeq==0.6.1p1
-PyYAML==3.11
+PyYAML==5.4
 swalign==0.3.1
 pyfaidx==0.2.7
 svgwrite==1.1.6
\ No newline at end of file