diff --git a/packages/components/package-lock.json b/packages/components/package-lock.json
index b0d87d0393..02704005b4 100644
--- a/packages/components/package-lock.json
+++ b/packages/components/package-lock.json
@@ -1,16 +1,16 @@
 {
   "name": "@labkey/components",
-  "version": "6.43.1",
+  "version": "6.43.2",
   "lockfileVersion": 3,
   "requires": true,
   "packages": {
     "": {
       "name": "@labkey/components",
-      "version": "6.43.1",
+      "version": "6.43.2",
       "license": "SEE LICENSE IN LICENSE.txt",
       "dependencies": {
         "@hello-pangea/dnd": "18.0.1",
-        "@labkey/api": "1.41.0",
+        "@labkey/api": "1.41.1",
         "@testing-library/dom": "~10.4.0",
         "@testing-library/jest-dom": "~6.6.3",
         "@testing-library/react": "~16.3.0",
@@ -3018,9 +3018,9 @@
       }
     },
     "node_modules/@labkey/api": {
-      "version": "1.41.0",
-      "resolved": "https://labkey.jfrog.io/artifactory/api/npm/libs-client/@labkey/api/-/@labkey/api-1.41.0.tgz",
-      "integrity": "sha512-FWhELnNLkTVNNGXOnPHFoLb/CvPKVnibvVnINGETh1rBUmp8UdGrSV2OuhhPEkuGoi/SGp2zI3dkkSYjRR20Eg=="
+      "version": "1.41.1",
+      "resolved": "https://labkey.jfrog.io/artifactory/api/npm/libs-client/@labkey/api/-/@labkey/api-1.41.1.tgz",
+      "integrity": "sha512-5CaGXA0Z2m/D7lDf8F8gZugQVxcWURpRsEdU+Xc/xn4Vz5ZdLjfgzyD87WsEtwNEi0Ed8Lw/BpsToFh80g+3IA=="
     },
     "node_modules/@labkey/build": {
       "version": "8.5.0",
diff --git a/packages/components/package.json b/packages/components/package.json
index 0e81de5f49..60bce62482 100644
--- a/packages/components/package.json
+++ b/packages/components/package.json
@@ -1,6 +1,6 @@
 {
   "name": "@labkey/components",
-  "version": "6.43.1",
+  "version": "6.43.2",
   "description": "Components, models, actions, and utility functions for LabKey applications and pages",
   "sideEffects": false,
   "files": [
@@ -50,7 +50,7 @@
   "homepage": "https://github.com/LabKey/labkey-ui-components#readme",
   "dependencies": {
     "@hello-pangea/dnd": "18.0.1",
-    "@labkey/api": "1.41.0",
+    "@labkey/api": "1.41.1",
     "@testing-library/dom": "~10.4.0",
     "@testing-library/jest-dom": "~6.6.3",
     "@testing-library/react": "~16.3.0",
diff --git a/packages/components/releaseNotes/components.md b/packages/components/releaseNotes/components.md
index f8700aa615..4c2ae20355 100644
--- a/packages/components/releaseNotes/components.md
+++ b/packages/components/releaseNotes/components.md
@@ -1,8 +1,14 @@
 # @labkey/components
 Components, models, actions, and utility functions for LabKey applications and pages
 
+### version 6.43.2
+*Released*: 23 May 2025
+- Add detailed auditing of domain changes & comment ability
+    - include `CommentTextArea` in `BaseDomainDesigner` for supplying user provided comment for domain updates
+    - wire up `auditUserComment` for `SampleTypeDesigner`, `DataClassDesigner` and `AssayDesignerPanels`
+
 ### version 6.43.1
-*Released*: 22 May 2025
+*Released*: 23 May 2025
 - Issue 53055: Check for multiple values in single value column
 
 ### version 6.43.0
diff --git a/packages/components/src/internal/components/domainproperties/BaseDomainDesigner.tsx b/packages/components/src/internal/components/domainproperties/BaseDomainDesigner.tsx
index 03c2ad713c..53b5c94f9d 100644
--- a/packages/components/src/internal/components/domainproperties/BaseDomainDesigner.tsx
+++ b/packages/components/src/internal/components/domainproperties/BaseDomainDesigner.tsx
@@ -1,4 +1,13 @@
-import React, { PureComponent, ComponentType, FC, memo, PropsWithChildren } from 'react';
+import React, {
+    PureComponent,
+    ComponentType,
+    FC,
+    memo,
+    PropsWithChildren,
+    useState,
+    useCallback,
+    useMemo,
+} from 'react';
 import { List } from 'immutable';
 
 import { getSubmitButtonClass, isApp } from '../../app/utils';
@@ -6,6 +15,10 @@ import { FormButtons } from '../../FormButtons';
 
 import { Alert } from '../base/Alert';
 
+import { CommentTextArea } from '../forms/input/CommentTextArea';
+
+import { useDataChangeCommentsRequired } from '../forms/input/useDataChangeCommentsRequired';
+
 import { getDomainBottomErrorMessage, getDomainHeaderName, getUpdatedVisitedPanelsList } from './actions';
 import { DOMAIN_ERROR_ID, SEVERITY_LEVEL_ERROR } from './constants';
 
@@ -119,8 +132,9 @@ interface BaseDomainDesignerProps extends PropsWithChildren {
     hasValidProperties: boolean;
     name: string;
     onCancel: () => void;
-    onFinish: () => void;
+    onFinish: (reason?: string) => void;
     saveBtnText?: string;
+    showUserComment?: boolean;
     submitting: boolean;
     visitedPanels: List<number>;
 }
@@ -137,7 +151,11 @@ export const BaseDomainDesigner: FC<BaseDomainDesignerProps> = memo(props => {
         onCancel,
         hasValidProperties,
         saveBtnText = 'Save',
+        showUserComment,
     } = props;
+    const [userComment, setUserComment] = useState<string>(undefined);
+    // skip useDataChangeCommentsRequired hook for LKS pages with showUserComment=false
+    const requiresUserComment = showUserComment ? useDataChangeCommentsRequired().requiresUserComment : false;
 
     // get a list of the domain names that have errors
     const errorDomains = domains
@@ -147,6 +165,15 @@ export const BaseDomainDesigner: FC<BaseDomainDesignerProps> = memo(props => {
     const bottomErrorMsg = getDomainBottomErrorMessage(exception, errorDomains, hasValidProperties, visitedPanels);
     const submitClassname = `save-button btn btn-${getSubmitButtonClass()}`;
 
+    const onSave = useCallback(() => {
+        onFinish(userComment);
+    }, [userComment, onFinish]);
+
+    const canSubmit = useMemo(() => {
+        if (submitting) return false;
+        return !requiresUserComment || userComment?.trim()?.length > 0;
+    }, [requiresUserComment, userComment, submitting]);
+
     return (
         <div className="domain-designer">
             {children}
@@ -159,7 +186,16 @@ export const BaseDomainDesigner: FC<BaseDomainDesignerProps> = memo(props => {
                 <button className="cancel-button btn btn-default" onClick={onCancel} type="button">
                     Cancel
                 </button>
-                <button className={submitClassname} disabled={submitting} onClick={onFinish} type="button">
+                {showUserComment && (
+                    <CommentTextArea
+                        actionName="Update"
+                        containerClassName="inline-comment"
+                        onChange={setUserComment}
+                        requiresUserComment={requiresUserComment}
+                        inline
+                    />
+                )}
+                <button className={submitClassname} disabled={!canSubmit} onClick={onSave} type="button">
                     {saveBtnText}
                 </button>
             </FormButtons>
diff --git a/packages/components/src/internal/components/domainproperties/actions.ts b/packages/components/src/internal/components/domainproperties/actions.ts
index aa328c8422..134ce52046 100644
--- a/packages/components/src/internal/components/domainproperties/actions.ts
+++ b/packages/components/src/internal/components/domainproperties/actions.ts
@@ -530,6 +530,7 @@ export function _parseCalculatedColumn(
 export interface SaveDomainOptions {
     /** Boolean indicating if rowIndices should be added to the error message objects */
     addRowIndexes?: boolean;
+    auditUserComment?: string;
     /** Container path where requests are made. Defaults to domain.container for updates. */
     containerPath?: string;
     /** DomainDesign to save */
@@ -576,6 +577,7 @@ export function saveDomain(options: SaveDomainOptions): Promise<DomainDesign> {
                 domainDesign: DomainDesign.serialize(domain),
                 includeWarnings,
                 options: options.options,
+                auditUserComment: options.auditUserComment,
                 success: successHandler,
                 failure: failureHandler,
             });
@@ -902,7 +904,7 @@ export function updateDataType(field: DomainField, value: any): DomainField {
             }) as DomainField;
         } else {
             if (PropDescType.isUser(value)) {
-                field = field.merge({lookupValidator: LOOKUP_VALIDATOR}) as DomainField;
+                field = field.merge({ lookupValidator: LOOKUP_VALIDATOR }) as DomainField;
             }
         }
     }
diff --git a/packages/components/src/internal/components/domainproperties/assay/AssayDesignerPanels.tsx b/packages/components/src/internal/components/domainproperties/assay/AssayDesignerPanels.tsx
index 1882f1e192..81af223700 100644
--- a/packages/components/src/internal/components/domainproperties/assay/AssayDesignerPanels.tsx
+++ b/packages/components/src/internal/components/domainproperties/assay/AssayDesignerPanels.tsx
@@ -232,14 +232,14 @@ export class AssayDesignerPanelsImpl extends React.PureComponent<Props, State> {
         );
     }
 
-    onFinish = (): void => {
+    onFinish = (reasonForUpdate?: string): void => {
         const { setSubmitting } = this.props;
         const { protocolModel } = this.state;
         const appIsValidMsg = this.getAppIsValidMsg();
         const textChoiceValidMsg = this.getTextChoiceUpdatesValidMsg();
         const isValid = protocolModel.isValid() && textChoiceValidMsg === undefined && appIsValidMsg === undefined;
 
-        this.props.onFinish(isValid, this.saveDomain);
+        this.props.onFinish(isValid, () => this.saveDomain(reasonForUpdate));
 
         if (!isValid) {
             const exception =
@@ -258,13 +258,13 @@ export class AssayDesignerPanelsImpl extends React.PureComponent<Props, State> {
         }
     };
 
-    saveDomain = (): void => {
+    saveDomain = (auditUserComment?: string): void => {
         const { beforeFinish, setSubmitting } = this.props;
         const { protocolModel } = this.state;
 
         beforeFinish?.(protocolModel);
 
-        saveAssayDesign(protocolModel)
+        saveAssayDesign(protocolModel, auditUserComment)
             .then(response => {
                 this.setState(() => ({ protocolModel }));
                 setSubmitting(false, () => {
@@ -418,6 +418,7 @@ export class AssayDesignerPanelsImpl extends React.PureComponent<Props, State> {
                 onCancel={onCancel}
                 onFinish={this.onFinish}
                 saveBtnText={saveBtnText}
+                showUserComment={!initModel.isNew() && appPropertiesOnly}
             >
                 <FilterCriteriaContext.Provider value={filterCriteriaState}>
                     <AssayPropertiesPanel
diff --git a/packages/components/src/internal/components/domainproperties/assay/actions.ts b/packages/components/src/internal/components/domainproperties/assay/actions.ts
index 71b0ca4ffa..71cd698f8d 100644
--- a/packages/components/src/internal/components/domainproperties/assay/actions.ts
+++ b/packages/components/src/internal/components/domainproperties/assay/actions.ts
@@ -27,11 +27,11 @@ import { handleRequestFailure } from '../../../request';
 
 import { AssayProtocolModel } from './models';
 
-export function saveAssayDesign(model: AssayProtocolModel): Promise<AssayProtocolModel> {
+export function saveAssayDesign(model: AssayProtocolModel, auditUserComment?: string): Promise<AssayProtocolModel> {
     return new Promise((resolve, reject) => {
         Ajax.request({
             url: ActionURL.buildURL('assay', 'saveProtocol.api', model.container),
-            jsonData: AssayProtocolModel.serialize(model),
+            jsonData: AssayProtocolModel.serialize(model, auditUserComment),
             success: Utils.getCallbackWrapper(response => {
                 resolve(AssayProtocolModel.create(response.data));
             }),
diff --git a/packages/components/src/internal/components/domainproperties/assay/models.ts b/packages/components/src/internal/components/domainproperties/assay/models.ts
index 29c81ecfcc..1016c89669 100644
--- a/packages/components/src/internal/components/domainproperties/assay/models.ts
+++ b/packages/components/src/internal/components/domainproperties/assay/models.ts
@@ -135,7 +135,7 @@ export class AssayProtocolModel extends ImmutableRecord({
         return new AssayProtocolModel({ ...raw, name, domains });
     }
 
-    static serialize(model: AssayProtocolModel): any {
+    static serialize(model: AssayProtocolModel, auditUserComment?: string): any {
         // need to serialize the DomainDesign objects to remove the unrecognized fields
         const domains = model.domains.map(domain => {
             return DomainDesign.serialize(domain);
@@ -143,6 +143,8 @@ export class AssayProtocolModel extends ImmutableRecord({
 
         const json = model.merge({ domains }).toJS();
 
+        if (auditUserComment) json.auditUserComment = auditUserComment;
+
         // only need to serialize the id and not the autoCopyTargetContainer object
         delete json.autoCopyTargetContainer;
         delete json.exception;
diff --git a/packages/components/src/internal/components/domainproperties/dataclasses/DataClassDesigner.tsx b/packages/components/src/internal/components/domainproperties/dataclasses/DataClassDesigner.tsx
index 149fc8df4f..0f1d911410 100644
--- a/packages/components/src/internal/components/domainproperties/dataclasses/DataClassDesigner.tsx
+++ b/packages/components/src/internal/components/domainproperties/dataclasses/DataClassDesigner.tsx
@@ -48,6 +48,7 @@ interface Props {
     headerText?: string;
     helpTopic?: string;
     initModel?: DataClassModel;
+    isUpdate?: boolean;
     isValidParentOptionsFn?: (row: any, isDataClass: boolean) => boolean;
     // loadNameExpressionOptions is a prop for testing purposes only, see default implementation below
     loadNameExpressionOptions?: (
@@ -61,11 +62,11 @@ interface Props {
     onChange?: (model: DataClassModel) => void;
     onComplete: (model: DataClassModel) => void;
     saveBtnText?: string;
-    showGenIdBanner?: boolean;
     validateNameExpressions?: boolean;
 }
 
 interface State {
+    auditUserComment?: string;
     model: DataClassModel;
     nameExpressionWarnings: string[];
     namePreviews: string[];
@@ -156,12 +157,12 @@ export class DataClassDesignerImpl extends PureComponent<DataClassDesignerProps,
         return name;
     };
 
-    onFinish = (): void => {
+    onFinish = (auditUserComment?: string): void => {
         const { defaultNameFieldConfig, setSubmitting, nounSingular } = this.props;
         const { model } = this.state;
         const isValid = model.isValid(defaultNameFieldConfig);
 
-        this.props.onFinish(isValid, this.saveDomain);
+        this.props.onFinish(isValid, () => this.saveDomain(false, auditUserComment));
 
         if (!isValid) {
             let exception: string;
@@ -207,7 +208,7 @@ export class DataClassDesignerImpl extends PureComponent<DataClassDesignerProps,
         return aliases;
     }
 
-    saveDomain = async (hasConfirmedNameExpression?: boolean): Promise<void> => {
+    saveDomain = async (hasConfirmedNameExpression?: boolean, auditUserComment?: string): Promise<void> => {
         const { api, beforeFinish, onComplete, setSubmitting, validateNameExpressions } = this.props;
         const { model } = this.state;
         const { name, domain } = model;
@@ -239,6 +240,7 @@ export class DataClassDesignerImpl extends PureComponent<DataClassDesignerProps,
                         this.setState({
                             nameExpressionWarnings: response.warnings,
                             namePreviews: response.previews,
+                            auditUserComment,
                         });
                     });
                     return;
@@ -261,6 +263,7 @@ export class DataClassDesignerImpl extends PureComponent<DataClassDesignerProps,
                 domain: domainDesign,
                 kind: Domain.KINDS.DATA_CLASS,
                 name: model.name,
+                auditUserComment,
                 options,
             });
 
@@ -340,6 +343,7 @@ export class DataClassDesignerImpl extends PureComponent<DataClassDesignerProps,
         setSubmitting(false, () => {
             this.setState({
                 nameExpressionWarnings: undefined,
+                auditUserComment: undefined,
             });
         });
     };
@@ -349,7 +353,7 @@ export class DataClassDesignerImpl extends PureComponent<DataClassDesignerProps,
             () => ({
                 nameExpressionWarnings: undefined,
             }),
-            () => this.saveDomain(true)
+            () => this.saveDomain(true, this.state.auditUserComment)
         );
     };
 
@@ -461,7 +465,7 @@ export class DataClassDesignerImpl extends PureComponent<DataClassDesignerProps,
             firstState,
             helpTopic,
             domainFormDisplayOptions,
-            showGenIdBanner,
+            isUpdate,
             allowParentAlias,
             allowFolderExclusion,
         } = this.props;
@@ -480,6 +484,7 @@ export class DataClassDesignerImpl extends PureComponent<DataClassDesignerProps,
                 onCancel={onCancel}
                 onFinish={this.onFinish}
                 saveBtnText={saveBtnText}
+                showUserComment={isUpdate && appPropertiesOnly}
             >
                 <DataClassPropertiesPanel
                     nounSingular={nounSingular}
@@ -504,7 +509,7 @@ export class DataClassDesignerImpl extends PureComponent<DataClassDesignerProps,
                     previewName={namePreviews?.[0]}
                     onNameFieldHover={this.onNameFieldHover}
                     nameExpressionGenIdProps={
-                        showGenIdBanner && hasGenIdInExpression
+                        isUpdate && hasGenIdInExpression
                             ? {
                                   containerPath: model.containerPath,
                                   dataTypeName: model.name,
diff --git a/packages/components/src/internal/components/domainproperties/samples/SampleTypeDesigner.tsx b/packages/components/src/internal/components/domainproperties/samples/SampleTypeDesigner.tsx
index b6fd4a92ed..a42e3a2976 100644
--- a/packages/components/src/internal/components/domainproperties/samples/SampleTypeDesigner.tsx
+++ b/packages/components/src/internal/components/domainproperties/samples/SampleTypeDesigner.tsx
@@ -104,6 +104,7 @@ interface Props {
     helpTopic?: string;
     includeDataClasses?: boolean;
     initModel?: DomainDetails;
+    isUpdate?: boolean;
     isValidParentOptionFn?: (row: any, isDataClass: boolean) => boolean;
     metricUnitProps?: MetricUnitProps;
     nameExpressionInfoUrl?: string;
@@ -113,11 +114,10 @@ interface Props {
     onCancel: () => void;
     onChange?: (model: SampleTypeModel) => void;
     onComplete: (response: DomainDesign) => void;
-    sampleAliasCaption?: string;
     sampleTypeCaption?: string;
     saveBtnText?: string;
     showAliquotOptions?: boolean;
-    showGenIdBanner?: boolean;
+    sampleAliasCaption?: string;
     showLinkToStudy?: boolean;
     showParentLabelPrefix?: boolean;
     useSeparateDataClassesAliasMenu?: boolean;
@@ -126,6 +126,7 @@ interface Props {
 }
 
 interface State {
+    auditUserComment?: string;
     error: React.ReactNode;
     model: SampleTypeModel;
     nameExpressionWarnings: string[];
@@ -327,7 +328,11 @@ export class SampleTypeDesignerImpl extends React.PureComponent<Props & Injected
     };
 
     onUniqueIdCancel = (): void => {
-        this.setState({ showUniqueIdConfirmation: false, uniqueIdsConfirmed: false });
+        this.setState({
+            showUniqueIdConfirmation: false,
+            uniqueIdsConfirmed: false,
+            auditUserComment: undefined,
+        });
     };
 
     onUniqueIdConfirm = (): void => {
@@ -338,7 +343,10 @@ export class SampleTypeDesignerImpl extends React.PureComponent<Props & Injected
         const { setSubmitting } = this.props;
 
         setSubmitting(false, () => {
-            this.setState({ nameExpressionWarnings: undefined });
+            this.setState({
+                nameExpressionWarnings: undefined,
+                auditUserComment: undefined,
+            });
         });
     };
 
@@ -348,19 +356,22 @@ export class SampleTypeDesignerImpl extends React.PureComponent<Props & Injected
         });
     };
 
-    onFinish = (): void => {
+    onFinish = (auditUserComment?: string): void => {
         const { defaultSampleFieldConfig, setSubmitting, metricUnitProps } = this.props;
         const { model, uniqueIdsConfirmed } = this.state;
 
         if (!model.isNew() && this.getNumNewUniqueIdFields() > 0 && !uniqueIdsConfirmed) {
-            this.setState({ showUniqueIdConfirmation: true });
+            this.setState({
+                showUniqueIdConfirmation: true,
+                auditUserComment
+            });
             return;
         }
 
         const metricUnitRequired = metricUnitProps?.metricUnitRequired;
         const isValid = model.isValid(defaultSampleFieldConfig, metricUnitRequired);
 
-        this.props.onFinish(isValid, this.saveDomain);
+        this.props.onFinish(isValid, () => this.saveDomain(false, auditUserComment));
 
         if (isValid) return;
 
@@ -382,15 +393,21 @@ export class SampleTypeDesignerImpl extends React.PureComponent<Props & Injected
 
         const updatedModel = model.set('exception', exception) as SampleTypeModel;
         setSubmitting(false, () => {
-            this.setState({ model: updatedModel }, () => {
-                scrollDomainErrorIntoView();
-            });
+            this.setState(
+                {
+                    model: updatedModel,
+                    auditUserComment,
+                },
+                () => {
+                    scrollDomainErrorIntoView();
+                }
+            );
         });
     };
 
-    saveDomain = async (hasConfirmedNameExpression?: boolean): Promise<void> => {
+    saveDomain = async (hasConfirmedNameExpression?: boolean, comment?: string): Promise<void> => {
         const { api, beforeFinish, setSubmitting } = this.props;
-        const { model } = this.state;
+        const { model, auditUserComment } = this.state;
         const { name, domain, description } = model;
         if (!hasConfirmedNameExpression) {
             beforeFinish?.(model);
@@ -492,6 +509,7 @@ export class SampleTypeDesignerImpl extends React.PureComponent<Props & Injected
                 kind: Domain.KINDS.SAMPLE_TYPE,
                 name,
                 options: details,
+                auditUserComment: auditUserComment ?? comment,
             });
             setSubmitting(false, () => {
                 this.props.onComplete(response);
@@ -621,7 +639,7 @@ export class SampleTypeDesignerImpl extends React.PureComponent<Props & Injected
             aliquotNamePatternProps,
             initModel,
             showAliquotOptions,
-            showGenIdBanner,
+            isUpdate,
         } = this.props;
         const {
             error,
@@ -667,6 +685,7 @@ export class SampleTypeDesignerImpl extends React.PureComponent<Props & Injected
                 onCancel={onCancel}
                 onFinish={this.onFinish}
                 saveBtnText={saveBtnText}
+                showUserComment={isUpdate && appPropertiesOnly}
             >
                 <SampleTypePropertiesPanel
                     api={api}
@@ -708,7 +727,7 @@ export class SampleTypeDesignerImpl extends React.PureComponent<Props & Injected
                     namePreviews={namePreviews}
                     onNameFieldHover={this.onNameFieldHover}
                     nameExpressionGenIdProps={
-                        showGenIdBanner && options && hasGenIdInExpression
+                        isUpdate && options && hasGenIdInExpression
                             ? {
                                   containerPath: model.containerPath,
                                   dataTypeName: options.get('name'),