[PA165985892] Bad GPML for Tacrolimus/Cyclosporine Pathway, Pharmacodynamics

[pharmgen]

Latest GPML for pathwayPA165985892 is obsolete.
Use this instead: PA165985892-new.gpml

Note that even the updated GPML has errors that must be fixed:

• 'MAPK14' [id:ad6d7]: Cellular location is 'Intracellular' but it's in a Nucleus.
• 'Upstream regulator' [id:ae5dd]: Missing PharmGKB Accession ID.
• 'Upstream regulator' [id:ae5dd]: BlackBox should be converted to Phenotype or Process.
• 'Immune stimulation' [id:b49e2]: Missing PharmGKB Accession ID.
• 'Immune stimulation' [id:b49e2]: BlackBox should be converted to Phenotype or Process.
• 'Cytokine production' [id:b6df0]: Missing PharmGKB Accession ID.
• 'Cytokine production' [id:b6df0]: BlackBox should be converted to Phenotype or Process.
• 'IL2' [id:bdb10]: Cellular location is 'Intracellular' but it's in a Nucleus.
• 'IL-2 DNA' [id:da5df]: Missing PharmGKB Accession ID.
• 'IL-2 DNA' [id:da5df]: Cellular location is 'Intracellular' but it's in a Nucleus.
• 'IL-2 DNA' [id:da5df]: BlackBox should be converted to Phenotype or Process.
• 'MAPK8' [id:e9dfb]: Cellular location is 'Intracellular' but it's in a Nucleus.
• 'NFAT-NFkB-AP1' [id:ea8cb]: Missing cellular location.
• 'Tacrolimus-FKBP1A' [id:ebaa0]: Drug Complex must specify drugComplexComponents.
• 'Upstream regulator' [id:edbd9]: Missing PharmGKB Accession ID.
• 'Upstream regulator' [id:edbd9]: BlackBox should be converted to Phenotype or Process.
• 'Cyclosporine-PPIA' [id:ef73b]: Drug Complex must specify drugComplexComponents.
• 'Upstream regulator' [id:f311c]: Missing PharmGKB Accession ID.
• 'Upstream regulator' [id:f311c]: BlackBox should be converted to Phenotype or Process.
• 'IL-2 dependent T-cell proliferation' [id:f41a8]: Missing PharmGKB Accession ID.
• 'IL-2 dependent T-cell proliferation' [id:f41a8]: BlackBox should be converted to Phenotype or Process.
• 'Immune response' [id:fd8e7]: Missing PharmGKB Accession ID.
• 'Immune response' [id:fd8e7]: BlackBox should be converted to Phenotype or Process.
• 'AP-1' [id:d40ce]: Cellular location is 'Intracellular' but it's in a Nucleus.
• Complex Assembly line [id:aba10] (from 'NFAT' [id:d8a49] to 'NFAT-NFkB-AP1' [id:ea8cb]): ComplexAssembly does not have additional nodes (i.e. nothing being assembled/disassembled).
• Complex Assembly line [id:b3259] (from 'FKBP1A' [id:c531d] to 'Tacrolimus-FKBP1A' [id:ebaa0]): ComplexAssembly does not have additional nodes (i.e. nothing being assembled/disassembled).
• Complex Assembly line [id:bf3df] (from 'tacrolimus' [id:c8de6] to 'Tacrolimus-FKBP1A' [id:ebaa0]): ComplexAssembly does not have additional nodes (i.e. nothing being assembled/disassembled).
• Activation line [id:e159f] (from 'NFAT-NFkB-AP1' [id:ea8cb] to 'IL-2 DNA' [id:da5df]): Missing evidence.
• Complex Assembly line [id:e46f5] (from 'PPIA' [id:dd602] to 'Cyclosporine-PPIA' [id:ef73b]): ComplexAssembly does not have additional nodes (i.e. nothing being assembled/disassembled).
• Complex Assembly line [id:id883dc089] (from 'AP-1' [id:d40ce] to 'NFAT-NFkB-AP1' [id:ea8cb]): ComplexAssembly does not have additional nodes (i.e. nothing being assembled/disassembled).
• Complex Assembly line [id:iddd335c9e] (from 'NFkB' [id:b291a] to 'NFAT-NFkB-AP1' [id:ea8cb]): ComplexAssembly does not have additional nodes (i.e. nothing being assembled/disassembled).
• Conversion line [id:ide9b58d10] (from 'IL-2 DNA' [id:da5df] to 'IL2' [id:bdb10]): Missing evidence.
• Complex Assembly line [id:bea51] (from 'cyclosporine' [id:dd40d] to 'Cyclosporine-PPIA' [id:ef73b]): ComplexAssembly does not have additional nodes (i.e. nothing being assembled/disassembled).
• Biochemical Reaction line [id:fe50a] (from 'NFAT' [id:d60a3] to 'NFAT' [id:ed832]): Missing evidence.