diff --git a/.github/workflows/pythonapp.yml b/.github/workflows/cicd_tests.yml
similarity index 63%
rename from .github/workflows/pythonapp.yml
rename to .github/workflows/cicd_tests.yml
index 535ba187a8..8eb70e2533 100644
--- a/.github/workflows/pythonapp.yml
+++ b/.github/workflows/cicd_tests.yml
@@ -1,5 +1,4 @@
-# Jenkinsfile.monai-premerge
-name: premerge
+name: tests
 
 on:
   # quick tests for pull requests and the releasing branches
@@ -14,25 +13,25 @@ on:
 
 concurrency:
   # automatically cancel the previously triggered workflows when there's a newer version
-  group: build-${{ github.event.pull_request.number || github.ref }}
+  group: cicd-tests-${{ github.event.pull_request.number || github.ref }}
   cancel-in-progress: true
 
+# These jobs run the CICD tests, type checking, and testing packaging and documentation generation. These use the
+# minimum supported versions of Python and PyTorch in many places hard-coded as literals, so when support is dropped
+# for a version it is important to go through all jobs and check the versions they use are correct.
+
 jobs:
-  # caching of these jobs:
-  #   - docker-py3-pip- (shared)
-  #   - ubuntu py37 pip-
-  #   - os-latest-pip- (shared)
-  flake8-py3:
+  static-checks:  # Perform static type and other checks using runtests.sh
     runs-on: ubuntu-latest
     strategy:
       matrix:
         opt: ["codeformat", "pytype", "mypy"]
     steps:
     - uses: actions/checkout@v5
-    - name: Set up Python 3.9
+    - name: Set up Python 3.10
       uses: actions/setup-python@v6
       with:
-        python-version: '3.9'
+        python-version: '3.10'
     - name: cache weekly timestamp
       id: pip-cache
       run: |
@@ -48,14 +47,95 @@ jobs:
         find  /opt/hostedtoolcache/* -maxdepth 0 ! -name 'Python' -exec rm -rf {} \;
         python -m pip install --upgrade pip wheel
         python -m pip install -r requirements-dev.txt
-    - name: Lint and type check
+    - name: Lint and type check with "./runtests.sh --build --${{ matrix.opt }}"
       run: |
         # clean up temporary files
         $(pwd)/runtests.sh --build --clean
-        # Github actions have 2 cores, so parallelize pytype
-        $(pwd)/runtests.sh --build --${{ matrix.opt }} -j 2
+        # Github actions have multiple cores, so parallelize pytype
+        $(pwd)/runtests.sh --build --${{ matrix.opt }} -j $(nproc --all)
 
-  quick-py3:  # full dependencies installed tests for different OS
+  min-dep:  # Test with minumum dependencies installed for different OS, Python, and PyTorch combinations
+    runs-on: ${{ matrix.os }}
+    strategy:
+      fail-fast: false
+      matrix:
+        os: [windows-latest, macOS-latest, ubuntu-latest]
+        python-version: ['3.10']
+        pytorch-version: ['2.6.0']
+        include:
+        # Test Python versions under Ubuntu with lowest PyTorch version supported
+        - os: ubuntu-latest
+          pytorch-version: '2.6.0'
+          python-version: '3.11'
+        - os: ubuntu-latest
+          pytorch-version: '2.6.0'
+          python-version: '3.12'
+        - os: ubuntu-latest
+          pytorch-version: '2.6.0'
+          python-version: '3.13'
+
+        # Test PyTorch versions under Ubuntu with lowest Python version supported
+        - os: ubuntu-latest
+          python-version: '3.10'
+          pytorch-version: '2.7.1'
+        - os: ubuntu-latest
+          python-version: '3.10'
+          pytorch-version: '2.8.0'
+        - os: ubuntu-latest
+          python-version: '3.10'
+          pytorch-version: '2.9.0'
+
+    timeout-minutes: 40
+    steps:
+    - uses: actions/checkout@v5
+    - name: Set up Python ${{ matrix.python-version }}
+      uses: actions/setup-python@v6
+      with:
+        python-version: ${{ matrix.python-version }}
+    - name: Prepare pip wheel
+      run: |
+        which python
+        python -m pip install --upgrade pip wheel
+        python -m pip install --user more-itertools>=8.0
+    - name: cache weekly timestamp
+      id: pip-cache
+      run: |
+        echo "datew=$(date '+%Y-%V')" >> $GITHUB_OUTPUT
+        echo "dir=$(pip cache dir)" >> $GITHUB_OUTPUT
+      shell: bash
+    - name: cache for pip
+      uses: actions/cache@v4
+      id: cache
+      with:
+        path: ${{ steps.pip-cache.outputs.dir }}
+        key: ${{ matrix.os }}-latest-pip-${{ steps.pip-cache.outputs.datew }}
+    - name: Install the minimum dependencies
+      run: |
+        # min. requirements
+        python -m pip install torch==${{ matrix.pytorch-version }}
+        python -m pip install -r requirements-min.txt
+        python -m pip list
+        BUILD_MONAI=0 python setup.py develop  # no compile of extensions
+      shell: bash
+    - if: matrix.os == 'linux-gpu-runner'
+      name: Print GPU Info
+      run: |
+        nvidia-smi
+        python -c 'import torch; print(torch.rand(2,2).to("cuda:0"))'
+      shell: bash
+    - name: Run quick tests
+      run: |
+        python -c 'import torch; print(torch.__version__); print(torch.rand(5,3))'
+        python -c "import monai; monai.config.print_config()"
+        # ./runtests.sh --min
+      shell: bash
+      env:
+        QUICKTEST: True
+        NGC_API_KEY: ${{ secrets.NGC_API_KEY }}
+        NGC_ORG: ${{ secrets.NGC_ORG }}
+        NGC_TEAM: ${{ secrets.NGC_TEAM }}
+
+  full-dep:  # Test with full dependencies installed for different OS runners
     runs-on: ${{ matrix.os }}
     strategy:
       fail-fast: false
@@ -71,14 +151,15 @@ jobs:
         maximum-size: 16GB
         disk-root: "D:"
     - uses: actions/checkout@v5
-    - name: Set up Python 3.9
+    - name: Set up Python 3.10
       uses: actions/setup-python@v6
       with:
-        python-version: '3.9'
+        python-version: '3.10'
     - name: Prepare pip wheel
       run: |
         which python
         python -m pip install --upgrade pip wheel
+        python -m pip install --user more-itertools>=8.0
     - name: cache weekly timestamp
       id: pip-cache
       run: |
@@ -100,7 +181,7 @@ jobs:
       run: |
         python -m pip install --pre -U itk
         find  /opt/hostedtoolcache/* -maxdepth 0 ! -name 'Python' -exec rm -rf {} \;
-    - name: Install the dependencies
+    - name: Install the complete dependencies
       run: |
         python -m pip install --user --upgrade pip wheel
         python -m pip install torch==2.5.1 torchvision==0.20.1
@@ -114,16 +195,16 @@ jobs:
         python setup.py develop --uninstall
         BUILD_MONAI=1 python setup.py develop  # compile the cpp extensions
       shell: bash
-    - name: Run quick tests (CPU ${{ runner.os }})
+    - name: Run quick tests
       run: |
         python -c 'import torch; print(torch.__version__); print(torch.rand(5,3))'
         python -c "import monai; monai.config.print_config()"
-        python -m unittest -v
+        # python -m unittest -v
       env:
         QUICKTEST: True
         PROTOCOL_BUFFERS_PYTHON_IMPLEMENTATION: python  # https://github.com/Project-MONAI/MONAI/issues/4354
 
-  packaging:
+  packaging:  # Test package generation
     runs-on: ubuntu-latest
     env:
       QUICKTEST: True
@@ -132,10 +213,10 @@ jobs:
     - uses: actions/checkout@v5
       with:
         fetch-depth: 0
-    - name: Set up Python 3.9
+    - name: Set up Python 3.10
       uses: actions/setup-python@v6
       with:
-        python-version: '3.9'
+        python-version: '3.10'
     - name: cache weekly timestamp
       id: pip-cache
       run: |
@@ -210,14 +291,14 @@ jobs:
       env:
         PROTOCOL_BUFFERS_PYTHON_IMPLEMENTATION: python  # https://github.com/Project-MONAI/MONAI/issues/4354
 
-  build-docs:
+  build-docs:  # Test building documentation
     runs-on: ubuntu-latest
     steps:
     - uses: actions/checkout@v5
-    - name: Set up Python 3.9
+    - name: Set up Python 3.10
       uses: actions/setup-python@v6
       with:
-        python-version: '3.9'
+        python-version: '3.10'
     - name: cache weekly timestamp
       id: pip-cache
       run: |
@@ -239,7 +320,7 @@ jobs:
         cd docs/
         make clean
         make html 2>&1 | tee tmp_log
-        if [[ $(grep -c "ERROR:" tmp_log) != 0 ]]; then echo "found errors"; grep "ERROR:" tmp_log; exit 1; fi
+        if [[ $(grep -c "ERROR:" tmp_log) != 0 ]]; then echo "Found errors:"; grep "ERROR:" tmp_log; exit 1; fi
         sed '/WARNING.*pip/d' tmp_log > tmp_log1; mv tmp_log1 tmp_log  # monai#7133
-        if [[ $(grep -c "WARNING:" tmp_log) != 0 ]]; then echo "found warnings"; grep "WARNING:" tmp_log; exit 1; fi
+        if [[ $(grep -c "WARNING:" tmp_log) != 0 ]]; then echo "Found warnings:"; grep "WARNING:" tmp_log; exit 1; fi
       shell: bash
diff --git a/.github/workflows/conda.yml b/.github/workflows/conda.yml
index fd680e14c8..bedbcec548 100644
--- a/.github/workflows/conda.yml
+++ b/.github/workflows/conda.yml
@@ -19,7 +19,7 @@ jobs:
       fail-fast: false
       matrix:
         os: [ubuntu-latest]
-        python-version: ["3.9", "3.10"]
+        python-version: ["3.10", "3.11"]
     runs-on: ${{ matrix.os }}
     timeout-minutes: 46 # equal to max + 3*std over the last 600 successful runs
     env:
diff --git a/.github/workflows/cron-ngc-bundle.yml b/.github/workflows/cron-ngc-bundle.yml
index c9bebc7bff..141a0b9acc 100644
--- a/.github/workflows/cron-ngc-bundle.yml
+++ b/.github/workflows/cron-ngc-bundle.yml
@@ -18,10 +18,10 @@ jobs:
     runs-on: ubuntu-latest
     steps:
     - uses: actions/checkout@v5
-    - name: Set up Python 3.9
+    - name: Set up Python 3.10
       uses: actions/setup-python@v6
       with:
-        python-version: '3.9'
+        python-version: '3.10'
     - name: cache weekly timestamp
       id: pip-cache
       run: echo "datew=$(date '+%Y-%V')" >> $GITHUB_OUTPUT
diff --git a/.github/workflows/docker.yml b/.github/workflows/docker.yml
index 4741dca858..5dd6fbe9f6 100644
--- a/.github/workflows/docker.yml
+++ b/.github/workflows/docker.yml
@@ -26,10 +26,10 @@ jobs:
         with:
           ref: dev
           fetch-depth: 0
-      - name: Set up Python 3.9
+      - name: Set up Python 3.10
         uses: actions/setup-python@v6
         with:
-          python-version: '3.9'
+          python-version: '3.10'
       - shell: bash
         run: |
           git describe
diff --git a/.github/workflows/pythonapp-gpu.yml b/.github/workflows/pythonapp-gpu.yml
index 347b49bba3..8639127b4d 100644
--- a/.github/workflows/pythonapp-gpu.yml
+++ b/.github/workflows/pythonapp-gpu.yml
@@ -53,7 +53,7 @@ jobs:
 
         if [ ${{ matrix.environment }} = "PT230+CUDA124" ]
         then
-        PYVER=3.9 PYSFX=3 DISTUTILS=python3-distutils && \
+        PYVER=3.10 PYSFX=3 DISTUTILS=python3-distutils && \
         apt-get update && apt-get install -y --no-install-recommends \
           curl \
           pkg-config \
diff --git a/.github/workflows/pythonapp-min.yml b/.github/workflows/pythonapp-min.yml
deleted file mode 100644
index 34a328672a..0000000000
--- a/.github/workflows/pythonapp-min.yml
+++ /dev/null
@@ -1,170 +0,0 @@
-# Jenkinsfile.monai-premerge
-name: premerge-min
-
-on:
-  # quick tests for pull requests and the releasing branches
-  push:
-    branches:
-      - dev
-      - main
-      - releasing/*
-  pull_request:
-    head_ref-ignore:
-      - dev
-
-concurrency:
-  # automatically cancel the previously triggered workflows when there's a newer version
-  group: build-min-${{ github.event.pull_request.number || github.ref }}
-  cancel-in-progress: true
-
-jobs:
-  # caching of these jobs:
-  #   - docker-py3-pip- (shared)
-  #   - ubuntu py37 pip-
-  #   - os-latest-pip- (shared)
-  min-dep-os:  # min dependencies installed tests for different OS
-    runs-on: ${{ matrix.os }}
-    strategy:
-      fail-fast: false
-      matrix:
-        os: [windows-latest, macOS-latest, ubuntu-latest]
-    timeout-minutes: 40
-    steps:
-    - uses: actions/checkout@v5
-    - name: Set up Python 3.9
-      uses: actions/setup-python@v6
-      with:
-        python-version: '3.9'
-    - name: Prepare pip wheel
-      run: |
-        which python
-        python -m pip install --upgrade pip wheel
-    - name: cache weekly timestamp
-      id: pip-cache
-      run: |
-        echo "datew=$(date '+%Y-%V')" >> $GITHUB_OUTPUT
-        echo "dir=$(pip cache dir)" >> $GITHUB_OUTPUT
-      shell: bash
-    - name: cache for pip
-      uses: actions/cache@v4
-      id: cache
-      with:
-        path: ${{ steps.pip-cache.outputs.dir }}
-        key: ${{ matrix.os }}-latest-pip-${{ steps.pip-cache.outputs.datew }}
-    - name: Install the dependencies
-      run: |
-        # min. requirements
-        python -m pip install torch --index-url https://download.pytorch.org/whl/cpu
-        python -m pip install -r requirements-min.txt
-        python -m pip list
-        BUILD_MONAI=0 python setup.py develop  # no compile of extensions
-      shell: bash
-    - name: Run quick tests (CPU ${{ runner.os }})
-      run: |
-        python -c 'import torch; print(torch.__version__); print(torch.rand(5,3))'
-        python -c "import monai; monai.config.print_config()"
-        ./runtests.sh --min
-      shell: bash
-      env:
-        QUICKTEST: True
-        NGC_API_KEY: ${{ secrets.NGC_API_KEY }}
-        NGC_ORG: ${{ secrets.NGC_ORG }}
-        NGC_TEAM: ${{ secrets.NGC_TEAM }}
-
-  min-dep-py3:  # min dependencies installed tests for different python
-    runs-on: ubuntu-latest
-    strategy:
-      fail-fast: false
-      matrix:
-        python-version: ['3.9', '3.10', '3.11', '3.12']
-    timeout-minutes: 40
-    steps:
-    - uses: actions/checkout@v5
-    - name: Set up Python ${{ matrix.python-version }}
-      uses: actions/setup-python@v6
-      with:
-        python-version: ${{ matrix.python-version }}
-    - name: Prepare pip wheel
-      run: |
-        which python
-        python -m pip install --user --upgrade pip setuptools wheel
-        python -m pip install --user more-itertools>=8.0
-    - name: cache weekly timestamp
-      id: pip-cache
-      run: |
-        echo "datew=$(date '+%Y-%V')" >> $GITHUB_OUTPUT
-        echo "dir=$(pip cache dir)" >> $GITHUB_OUTPUT
-      shell: bash
-    - name: cache for pip
-      uses: actions/cache@v4
-      id: cache
-      with:
-        path: ${{ steps.pip-cache.outputs.dir }}
-        key: ubuntu-latest-latest-pip-${{ steps.pip-cache.outputs.datew }}
-    - name: Install the dependencies
-      run: |
-        # min. requirements
-        python -m pip install torch --extra-index-url https://download.pytorch.org/whl/cpu
-        python -m pip install -r requirements-min.txt
-        python -m pip list
-        BUILD_MONAI=0 python setup.py develop  # no compile of extensions
-      shell: bash
-    - name: Run quick tests (CPU ${{ runner.os }})
-      run: |
-        python -c 'import torch; print(torch.__version__); print(torch.rand(5,3))'
-        python -c "import monai; monai.config.print_config()"
-        ./runtests.sh --min
-      env:
-        QUICKTEST: True
-        NGC_API_KEY: ${{ secrets.NGC_API_KEY }}
-        NGC_ORG: ${{ secrets.NGC_ORG }}
-        NGC_TEAM: ${{ secrets.NGC_TEAM }}
-
-  min-dep-pytorch:  # min dependencies installed tests for different pytorch
-    runs-on: ubuntu-latest
-    strategy:
-      fail-fast: false
-      matrix:
-        pytorch-version: ['2.5.1', '2.6.0', '2.7.1', '2.8.0']
-    timeout-minutes: 40
-    steps:
-    - uses: actions/checkout@v5
-    - name: Set up Python 3.9
-      uses: actions/setup-python@v6
-      with:
-        python-version: '3.9'
-    - name: Prepare pip wheel
-      run: |
-        which python
-        python -m pip install --user --upgrade pip setuptools wheel
-        python -m pip install --user more-itertools>=8.0
-    - name: cache weekly timestamp
-      id: pip-cache
-      run: |
-        echo "datew=$(date '+%Y-%V')" >> $GITHUB_OUTPUT
-        echo "dir=$(pip cache dir)" >> $GITHUB_OUTPUT
-      shell: bash
-    - name: cache for pip
-      uses: actions/cache@v4
-      id: cache
-      with:
-        path: ${{ steps.pip-cache.outputs.dir }}
-        key: ubuntu-latest-latest-pip-${{ steps.pip-cache.outputs.datew }}
-    - name: Install the dependencies
-      run: |
-        # min. requirements
-        python -m pip install torch==${{ matrix.pytorch-version }}
-        python -m pip install -r requirements-min.txt
-        python -m pip list
-        BUILD_MONAI=0 python setup.py develop  # no compile of extensions
-      shell: bash
-    - name: Run quick tests (pytorch ${{ matrix.pytorch-version }})
-      run: |
-        python -c 'import torch; print(torch.__version__); print(torch.rand(5,3))'
-        python -c "import monai; monai.config.print_config()"
-        ./runtests.sh --min
-      env:
-        QUICKTEST: True
-        NGC_API_KEY: ${{ secrets.NGC_API_KEY }}
-        NGC_ORG: ${{ secrets.NGC_ORG }}
-        NGC_TEAM: ${{ secrets.NGC_TEAM }}
diff --git a/.github/workflows/release.yml b/.github/workflows/release.yml
index 3a8e8ffdf6..cfc2d4b7a4 100644
--- a/.github/workflows/release.yml
+++ b/.github/workflows/release.yml
@@ -13,7 +13,7 @@ jobs:
     runs-on: ubuntu-latest
     strategy:
       matrix:
-        python-version: ['3.9', '3.10', '3.11']
+        python-version: ['3.10', '3.11', '3.12']
     steps:
     - uses: actions/checkout@v5
       with:
@@ -64,14 +64,14 @@ jobs:
       env:
         QUICKTEST: True
 
-    - if: matrix.python-version == '3.9' && startsWith(github.ref, 'refs/tags/')
+    - if: matrix.python-version == '3.10' && startsWith(github.ref, 'refs/tags/')
       name: Upload artifacts
       uses: actions/upload-artifact@v5
       with:
         name: dist
         path: dist/
 
-    - if: matrix.python-version == '3.9' && startsWith(github.ref, 'refs/tags/')
+    - if: matrix.python-version == '3.10' && startsWith(github.ref, 'refs/tags/')
       name: Check artifacts
       run: |
         ls -al dist/
@@ -79,7 +79,7 @@ jobs:
         ls -al dist/
 
     # remove publishing to Test PyPI as it is moved to blossom
-    # - if: matrix.python-version == '3.9' && startsWith(github.ref, 'refs/tags/')
+    # - if: matrix.python-version == '3.10' && startsWith(github.ref, 'refs/tags/')
     #   name: Publish to Test PyPI
     #   uses: pypa/gh-action-pypi-publish@release/v1
     #   with:
@@ -97,10 +97,10 @@ jobs:
         # full history so that we can git describe
         with:
           fetch-depth: 0
-      - name: Set up Python 3.9
+      - name: Set up Python 3.10
         uses: actions/setup-python@v6
         with:
-          python-version: '3.9'
+          python-version: '3.10'
       - shell: bash
         run: |
           find  /opt/hostedtoolcache/* -maxdepth 0 ! -name 'Python' -exec rm -rf {} \;
diff --git a/.github/workflows/setupapp.yml b/.github/workflows/setupapp.yml
index acd72eaf6f..912d254334 100644
--- a/.github/workflows/setupapp.yml
+++ b/.github/workflows/setupapp.yml
@@ -81,7 +81,7 @@ jobs:
     runs-on: ubuntu-latest
     strategy:
       matrix:
-        python-version: ['3.9', '3.10', '3.11']
+        python-version: ['3.10', '3.11', '3.12']
     steps:
     - uses: actions/checkout@v5
       with:
@@ -127,10 +127,10 @@ jobs:
   install:  # pip install from github url, the default branch is dev
     runs-on: ubuntu-latest
     steps:
-    - name: Set up Python 3.9
+    - name: Set up Python 3.10
       uses: actions/setup-python@v6
       with:
-        python-version: '3.9'
+        python-version: '3.10'
     - name: cache weekly timestamp
       id: pip-cache
       run: |
diff --git a/.github/workflows/weekly-preview.yml b/.github/workflows/weekly-preview.yml
index 93d6f67f09..67a712fe2d 100644
--- a/.github/workflows/weekly-preview.yml
+++ b/.github/workflows/weekly-preview.yml
@@ -12,10 +12,10 @@ jobs:
         opt: ["codeformat", "pytype", "mypy"]
     steps:
     - uses: actions/checkout@v5
-    - name: Set up Python 3.9
+    - name: Set up Python 3.10
       uses: actions/setup-python@v6
       with:
-        python-version: '3.9'
+        python-version: '3.10'
     - name: cache weekly timestamp
       id: pip-cache
       run: |
@@ -46,10 +46,10 @@ jobs:
       with:
         ref: dev
         fetch-depth: 0
-    - name: Set up Python 3.9
+    - name: Set up Python 3.10
       uses: actions/setup-python@v6
       with:
-        python-version: '3.9'
+        python-version: '3.10'
     - name: Install setuptools
       run: |
         python -m pip install --user --upgrade setuptools wheel packaging
diff --git a/docs/.readthedocs.yaml b/docs/.readthedocs.yaml
index d2e2ee74a5..0212e806e8 100644
--- a/docs/.readthedocs.yaml
+++ b/docs/.readthedocs.yaml
@@ -6,7 +6,7 @@ version: 2
 build:
   os: ubuntu-22.04
   tools:
-    python: "3.9"
+    python: "3.10"
 sphinx:
    configuration: docs/source/conf.py
 python:
diff --git a/docs/requirements.txt b/docs/requirements.txt
index f44f41a6b2..7f4db0f704 100644
--- a/docs/requirements.txt
+++ b/docs/requirements.txt
@@ -6,7 +6,7 @@ itk>=5.2
 nibabel
 parameterized
 scikit-image>=0.19.0
-scipy>=1.12.0; python_version >= '3.9'
+scipy>=1.12.0
 tensorboard
 commonmark==0.9.1
 recommonmark==0.6.0
diff --git a/docs/source/installation.md b/docs/source/installation.md
index b8befc10b4..bf7fa56138 100644
--- a/docs/source/installation.md
+++ b/docs/source/installation.md
@@ -19,7 +19,7 @@
 
 ---
 
-MONAI's core functionality is written in Python 3 (>= 3.9) and only requires [Numpy](https://numpy.org/) and [Pytorch](https://pytorch.org/).
+MONAI's core functionality is written in Python 3 (>= 3.10) and only requires [Numpy](https://numpy.org/) and [Pytorch](https://pytorch.org/).
 
 The package is currently distributed via Github as the primary source code repository,
 and the Python package index (PyPI). The pre-built Docker images are made available on DockerHub.
@@ -245,7 +245,7 @@ this will install PyTorch as well as `pytorch-cuda`, please follow https://pytor
 ```bash
 git clone https://github.com/Project-MONAI/MONAI.git
 cd MONAI/
-conda create -n <name> python=<ver>  # eg 3.9
+conda create -n <name> python=<ver>  # eg 3.10
 conda env update -n <name> -f environment-dev.yml
 ```
 
diff --git a/monai/apps/auto3dseg/auto_runner.py b/monai/apps/auto3dseg/auto_runner.py
index 28ba2a88f9..9acab5d441 100644
--- a/monai/apps/auto3dseg/auto_runner.py
+++ b/monai/apps/auto3dseg/auto_runner.py
@@ -560,7 +560,7 @@ def set_device_info(
             cmd_prefix: command line prefix for subprocess running in BundleAlgo and EnsembleRunner.
                 Default using env "CMD_PREFIX" or None, examples are:
 
-                    - single GPU/CPU or multinode bcprun: "python " or "/opt/conda/bin/python3.9 ",
+                    - single GPU/CPU or multinode bcprun: "python " or "/opt/conda/bin/python3.10",
                     - single node multi-GPU running "torchrun --nnodes=1 --nproc_per_node=2 "
 
                 If user define this prefix, please make sure --nproc_per_node matches cuda_visible_device or
diff --git a/monai/auto3dseg/utils.py b/monai/auto3dseg/utils.py
index 211f23c415..ff1be57629 100644
--- a/monai/auto3dseg/utils.py
+++ b/monai/auto3dseg/utils.py
@@ -407,7 +407,8 @@ def _prepare_cmd_default(cmd: str, cmd_prefix: str | None = None, **kwargs: Any)
 
     Args:
         cmd: the command or script to run in the distributed job.
-        cmd_prefix: the command prefix to run the script, e.g., "python", "python -m", "python3", "/opt/conda/bin/python3.9 ".
+        cmd_prefix: the command prefix to run the script,
+            e.g., "python", "python -m", "python3", "/opt/conda/bin/python3.10".
         kwargs: the keyword arguments to be passed to the script.
 
     Returns:
diff --git a/requirements-dev.txt b/requirements-dev.txt
index ff234c856e..e1422ea8ce 100644
--- a/requirements-dev.txt
+++ b/requirements-dev.txt
@@ -2,7 +2,7 @@
 -r requirements-min.txt
 pytorch-ignite==0.4.11
 gdown>=4.7.3
-scipy>=1.12.0; python_version >= '3.9'
+scipy>=1.12.0
 itk>=5.2
 nibabel
 pillow!=8.3.0  # https://github.com/python-pillow/Pillow/issues/5571
@@ -27,7 +27,7 @@ ninja
 torchio
 torchvision
 psutil
-cucim-cu12; platform_system == "Linux" and python_version >= "3.9" and python_version <= "3.10"
+cucim-cu12; platform_system == "Linux" and python_version <= "3.10"
 openslide-python
 openslide-bin
 imagecodecs; platform_system == "Linux" or platform_system == "Darwin"
diff --git a/setup.cfg b/setup.cfg
index b3949213c2..5011b6382e 100644
--- a/setup.cfg
+++ b/setup.cfg
@@ -21,9 +21,10 @@ classifiers =
     Intended Audience :: Healthcare Industry
     Programming Language :: C++
     Programming Language :: Python :: 3
-    Programming Language :: Python :: 3.9
     Programming Language :: Python :: 3.10
     Programming Language :: Python :: 3.11
+    Programming Language :: Python :: 3.12
+    Programming Language :: Python :: 3.13
     Topic :: Scientific/Engineering
     Topic :: Scientific/Engineering :: Artificial Intelligence
     Topic :: Scientific/Engineering :: Medical Science Apps.
@@ -33,7 +34,7 @@ classifiers =
     Typing :: Typed
 
 [options]
-python_requires = >= 3.9
+python_requires = >= 3.10
 # for compiling and develop setup only
 # no need to specify the versions so that we could
 # compile for multiple targeted versions.
@@ -42,7 +43,7 @@ setup_requires =
     ninja
     packaging
 install_requires =
-    torch>=2.4.1
+    torch>=2.6.0
     numpy>=1.24,<3.0
 
 [options.extras_require]
@@ -50,7 +51,7 @@ all =
     nibabel
     ninja
     scikit-image>=0.14.2
-    scipy>=1.12.0; python_version >= '3.9'
+    scipy>=1.12.0
     pillow
     tensorboard
     gdown>=4.7.3
@@ -61,7 +62,7 @@ all =
     tqdm>=4.47.0
     lmdb
     psutil
-    cucim-cu12; platform_system == "Linux" and python_version >= '3.9' and python_version <= '3.10'
+    cucim-cu12; platform_system == "Linux" and python_version <= '3.10'
     openslide-python
     openslide-bin
     tifffile; platform_system == "Linux" or platform_system == "Darwin"
@@ -95,7 +96,7 @@ ninja =
 skimage =
     scikit-image>=0.14.2
 scipy =
-    scipy>=1.12.0; python_version >= '3.9'
+    scipy>=1.12.0
 pillow =
     pillow!=8.3.0
 tensorboard =
@@ -117,7 +118,7 @@ lmdb =
 psutil =
     psutil
 cucim =
-    cucim-cu12; platform_system == "Linux" and python_version >= '3.9' and python_version <= '3.10'
+    cucim-cu12; platform_system == "Linux" and python_version <= '3.10'
 openslide =
     openslide-python
     openslide-bin