diff --git a/.github/workflows/scientific-validation.yml b/.github/workflows/scientific-validation.yml
new file mode 100644
index 0000000..b953d34
--- /dev/null
+++ b/.github/workflows/scientific-validation.yml
@@ -0,0 +1,82 @@
+name: Scientific Validation
+
+on:
+  workflow_dispatch:
+  schedule:
+    - cron: "15 2 * * 2"
+
+permissions:
+  contents: read
+
+concurrency:
+  group: scientific-validation
+  cancel-in-progress: false
+
+jobs:
+  offline-scientific-validation:
+    name: Offline Scientific Validation
+    runs-on: ubuntu-latest
+
+    steps:
+      - name: Checkout
+        uses: actions/checkout@de0fac2e4500dabe0009e67214ff5f5447ce83dd # v6.0.2
+
+      - name: Set up Python
+        uses: actions/setup-python@a309ff8b426b58ec0e2a45f0f869d46889d02405 # v6.2.0
+        with:
+          python-version: "3.11"
+
+      - name: Install project
+        run: |
+          python -m pip install --upgrade pip
+          pip install -e ".[dev]"
+
+      - name: Generate offline scientific validation reports
+        run: |
+          mkdir -p artifacts/scientific-validation/offline
+          python scripts/scientific_validation_report.py \
+            --json \
+            --persistence-dir artifacts/scientific-validation/offline/bundles \
+            --output-json artifacts/scientific-validation/offline/report.json \
+            --output-markdown artifacts/scientific-validation/offline/report.md
+
+      - name: Upload offline scientific validation artifacts
+        uses: actions/upload-artifact@bbbca2ddaa5d8feaa63e36b76fdaad77386f024f # v7.0.0
+        with:
+          name: scientific-validation-offline
+          path: artifacts/scientific-validation/offline/**
+
+  live-concordance-panel:
+    name: Live Concordance Panel
+    if: ${{ secrets.CTX_API_KEY != '' }}
+    runs-on: ubuntu-latest
+    env:
+      CTX_API_KEY: ${{ secrets.CTX_API_KEY }}
+
+    steps:
+      - name: Checkout
+        uses: actions/checkout@de0fac2e4500dabe0009e67214ff5f5447ce83dd # v6.0.2
+
+      - name: Set up Python
+        uses: actions/setup-python@a309ff8b426b58ec0e2a45f0f869d46889d02405 # v6.2.0
+        with:
+          python-version: "3.11"
+
+      - name: Install project
+        run: |
+          python -m pip install --upgrade pip
+          pip install -e ".[dev]"
+
+      - name: Generate live concordance panel reports
+        run: |
+          mkdir -p artifacts/scientific-validation/live
+          python scripts/live_concordance_panel.py \
+            --json \
+            --output-json artifacts/scientific-validation/live/report.json \
+            --output-markdown artifacts/scientific-validation/live/report.md
+
+      - name: Upload live concordance artifacts
+        uses: actions/upload-artifact@bbbca2ddaa5d8feaa63e36b76fdaad77386f024f # v7.0.0
+        with:
+          name: scientific-validation-live
+          path: artifacts/scientific-validation/live/**
diff --git a/docs/testing_matrix.md b/docs/testing_matrix.md
index 2fa4d75..bd12769 100644
--- a/docs/testing_matrix.md
+++ b/docs/testing_matrix.md
@@ -7,8 +7,8 @@
 | Cross-transport parity | Tool catalog/metadata consistency, shared audit logs | `pytest tests/test_mcp_conformance_suite.py` |
 | Interop – live MCP | Public interop builders over HTTP transport, partial-data tolerance, handoff object shape, and explicit live fixture refresh workflow | `python scripts/mcp_interop_smoke.py --endpoint http://127.0.0.1:8000/mcp --json`, `python scripts/mcp_interop_smoke.py --endpoint http://127.0.0.1:8000/mcp --capture-dir tests/golden/interop_live --refresh-live-fixtures --json`, and `.github/workflows/live-interop-smoke.yml` |
 | Predictive guardrails | Guardrail enforcement, audit bundle persistence | `pytest tests/test_predictive_regression.py` |
-| Scientific validation | Offline orchestrator scenario scorecards, evidence-assessment rollups, interop attachment coverage | `python scripts/scientific_validation_report.py --json` and `pytest tests/workflows/test_scientific_validation_report.py` |
-| Live concordance panel | CTX-backed ToxVal reference cases with expected observed-concordance outcomes and drift detection | `python scripts/live_concordance_panel.py --json` and `pytest tests/workflows/test_live_concordance_panel.py` |
+| Scientific validation | Offline orchestrator scenario scorecards, evidence-assessment rollups, interop attachment coverage | `python scripts/scientific_validation_report.py --json`, `pytest tests/workflows/test_scientific_validation_report.py`, and `.github/workflows/scientific-validation.yml` |
+| Live concordance panel | CTX-backed ToxVal reference cases with expected observed-concordance outcomes and drift detection | `python scripts/live_concordance_panel.py --json`, `pytest tests/workflows/test_live_concordance_panel.py`, and `.github/workflows/scientific-validation.yml` |
 | CTX connectivity | Live API health, credential validation | `scripts/smoke_ctx.sh` |
 | Agent integration | Codex/Gemini/Claude CLI flows | Follow `docs/integration_guides/mcp_integration.md` |
 
diff --git a/docs/workflow_testing_strategy.md b/docs/workflow_testing_strategy.md
index 098be8f..040dc03 100644
--- a/docs/workflow_testing_strategy.md
+++ b/docs/workflow_testing_strategy.md
@@ -27,6 +27,7 @@
 | Pipeline | Trigger | Suites | Reporting |
 | --- | --- | --- | --- |
 | PR Gate | Every pull request | Unit + contract + fast orchestrator smoke scenarios | Pytest JUnit + summary comment |
+| Scientific validation automation | Weekly on Tuesday plus manual dispatch | Offline scenario scorecards and live concordance drift checks | JSON/Markdown artifacts uploaded by `.github/workflows/scientific-validation.yml` |
 | Nightly Sandbox | 01:00 UTC daily | Full orchestrator scenarios, predictive regression, metadata validation | HTML bundle reports, JSON provenance summaries, Slack/email alerts |
 | Weekly Load | Off-peak (e.g., Sunday) | Locust/k6 runs at 10× expected load | Aggregated latency/throughput dashboards, CSV export |
 
@@ -54,8 +55,8 @@
    - Author Locust file targeting websocket endpoints; parameterize chemical lists and concurrency.
    - Provide k6 script for REST-based predictive services.
 5. **Automation**
-   - Create GitHub Actions workflows (`ci-workflows.yml`, `nightly-workflows.yml`) wiring environment secrets, persistence directories, and artifact uploads.
-   - Ensure nightly job stores bundle metadata + reports in `artifacts/workflows/<date>/`.
+   - `.github/workflows/scientific-validation.yml` now runs the offline report on every scheduled/manual execution and runs the live concordance panel when `CTX_API_KEY` is available, uploading JSON/Markdown artifacts for both.
+   - Extend this into a broader nightly workflow once orchestrator scenarios beyond the offline suite are stable enough for routine CI execution.
 
 ## Risks & Mitigations
 - **External API instability:** add sandbox fallback configuration and skip markers when endpoints are offline; ensure nightly job reports skips.
diff --git a/tests/test_workflow_hardening.py b/tests/test_workflow_hardening.py
index 79088bf..b917de0 100644
--- a/tests/test_workflow_hardening.py
+++ b/tests/test_workflow_hardening.py
@@ -71,3 +71,19 @@ def test_live_interop_smoke_workflow_exists_with_pinned_tooling() -> None:
     assert "actions/setup-python@" in text
     assert "uvicorn epacomp_tox.transport.websocket:app" in text
     assert "scripts/mcp_interop_smoke.py" in text
+
+
+def test_scientific_validation_workflow_exists_with_artifact_capture() -> None:
+    text = _workflow_text("scientific-validation.yml")
+    assert "name: Scientific Validation" in text
+    assert "workflow_dispatch:" in text
+    assert 'cron: "15 2 * * 2"' in text
+    assert "secrets.CTX_API_KEY" in text
+    assert "actions/checkout@" in text
+    assert "actions/setup-python@" in text
+    assert "actions/upload-artifact@" in text
+    assert 'pip install -e ".[dev]"' in text
+    assert "scripts/scientific_validation_report.py" in text
+    assert "scripts/live_concordance_panel.py" in text
+    assert "artifacts/scientific-validation/offline/report.json" in text
+    assert "artifacts/scientific-validation/live/report.json" in text