diff --git a/src/deadline/client/cli/_common.py b/src/deadline/client/cli/_common.py
index b69091141..336f7185b 100644
--- a/src/deadline/client/cli/_common.py
+++ b/src/deadline/client/cli/_common.py
@@ -32,7 +32,10 @@
 from contextlib import ExitStack
 from deadline.job_attachments.progress_tracker import ProgressReportMetadata
 
+from .. import api as _api
 from ..config import config_file
+from ..config.config_file import _SETTING_FARM_ID as SETTING_FARM_ID
+from ..config.config_file import _SETTING_QUEUE_ID as SETTING_QUEUE_ID
 from ..exceptions import DeadlineOperationError
 from ..job_bundle import deadline_yaml_dump
 from ._groups._sigint_handler import SigIntHandler
@@ -87,6 +90,40 @@ def wraps(ctx: click.Context, *args, **kwargs):
     return wraps
 
 
+def _auto_select_farm(config: Optional[ConfigParser] = None) -> Optional[str]:
+    """Auto-select farm ID if exactly one farm is available."""
+    try:
+        logger.debug("Auto-select farm: listing farms...")
+        farms = _api.list_farms(config=config).get("farms", [])
+        logger.debug("Auto-select farm: found %d farm(s)", len(farms))
+        if len(farms) == 1:
+            farm_id = farms[0]["farmId"]
+            click.echo(f"Auto-selected the only available farm: {farm_id}")
+            return farm_id
+    except Exception:
+        logger.debug("Auto-select farm failed", exc_info=True)
+    return None
+
+
+def _auto_select_queue(config: Optional[ConfigParser] = None) -> Optional[str]:
+    """Auto-select queue ID if exactly one queue is available in the current farm."""
+    try:
+        farm_id = config_file.get_setting(SETTING_FARM_ID, config=config)
+        if not farm_id:
+            logger.debug("Auto-select queue: no farm_id configured")
+            return None
+        logger.debug("Auto-select queue: listing queues for farm %s...", farm_id)
+        queues = _api.list_queues(farmId=farm_id, config=config).get("queues", [])
+        logger.debug("Auto-select queue: found %d queue(s) in farm %s", len(queues), farm_id)
+        if len(queues) == 1:
+            queue_id = queues[0]["queueId"]
+            click.echo(f"Auto-selected the only available queue: {queue_id}")
+            return queue_id
+    except Exception:
+        logger.debug("Auto-select queue failed", exc_info=True)
+    return None
+
+
 def _apply_cli_options_to_config(
     *, config: Optional[ConfigParser] = None, required_options: Set[str] = set(), **args
 ) -> Optional[ConfigParser]:
@@ -109,11 +146,11 @@ def _apply_cli_options_to_config(
 
         farm_id = args.pop("farm_id", None)
         if farm_id:
-            config_file.set_setting("defaults.farm_id", farm_id, config=config)
+            config_file.set_setting(SETTING_FARM_ID, farm_id, config=config)
 
         queue_id = args.pop("queue_id", None)
         if queue_id:
-            config_file.set_setting("defaults.queue_id", queue_id, config=config)
+            config_file.set_setting(SETTING_QUEUE_ID, queue_id, config=config)
 
         storage_profile_id = args.pop("storage_profile_id", None)
         if storage_profile_id:
@@ -139,16 +176,28 @@ def _apply_cli_options_to_config(
         for name in ["profile", "farm_id", "queue_id", "job_id", "storage_profile_id"]:
             args.pop(name, None)
 
-    # Check that the required options have values
+    # Check that the required options have values, auto-selecting if only one exists
     if "farm_id" in required_options:
         required_options.remove("farm_id")
-        if not config_file.get_setting("defaults.farm_id", config=config):
-            raise click.UsageError("Missing '--farm-id' or default Farm ID configuration")
+        if not config_file.get_setting(SETTING_FARM_ID, config=config):
+            farm_id = _auto_select_farm(config)
+            if farm_id:
+                if config is None:
+                    config = config_file.read_config()
+                config_file.set_setting(SETTING_FARM_ID, farm_id, config=config)
+            else:
+                raise click.UsageError("Missing '--farm-id' or default Farm ID configuration")
 
     if "queue_id" in required_options:
         required_options.remove("queue_id")
-        if not config_file.get_setting("defaults.queue_id", config=config):
-            raise click.UsageError("Missing '--queue-id' or default Queue ID configuration")
+        if not config_file.get_setting(SETTING_QUEUE_ID, config=config):
+            queue_id = _auto_select_queue(config)
+            if queue_id:
+                if config is None:
+                    config = config_file.read_config()
+                config_file.set_setting(SETTING_QUEUE_ID, queue_id, config=config)
+            else:
+                raise click.UsageError("Missing '--queue-id' or default Queue ID configuration")
 
     if "job_id" in required_options:
         required_options.remove("job_id")
diff --git a/src/deadline/client/config/config_file.py b/src/deadline/client/config/config_file.py
index 9ddcee1ac..39774c28c 100644
--- a/src/deadline/client/config/config_file.py
+++ b/src/deadline/client/config/config_file.py
@@ -51,6 +51,10 @@
 __config_file_path = None
 __config_mtime = None
 
+# Setting name constants
+_SETTING_FARM_ID = "defaults.farm_id"
+_SETTING_QUEUE_ID = "defaults.queue_id"
+
 # This value defines the AWS Deadline Cloud settings structure. For each named setting,
 # it stores:
 # "default" - The default value.
@@ -76,7 +80,7 @@
         "is_path": True,
         "description": "The directory in which to place the job submission history for this AWS profile name.",
     },
-    "defaults.farm_id": {
+    _SETTING_FARM_ID: {
         "default": "",
         "depend": "defaults.aws_profile_name",
         "section_format": "{}",
@@ -84,13 +88,13 @@
     },
     "settings.storage_profile_id": {
         "default": "",
-        "depend": "defaults.farm_id",
+        "depend": _SETTING_FARM_ID,
         "section_format": "{}",
         "description": "The storage profile that this workstation conforms to. It specifies where shared file systems are mounted, and where named job attachments should go.",
     },
-    "defaults.queue_id": {
+    _SETTING_QUEUE_ID: {
         "default": "",
-        "depend": "defaults.farm_id",
+        "depend": _SETTING_FARM_ID,
         "section_format": "{}",
         "description": "The Queue ID to use by default.",
     },
@@ -121,7 +125,7 @@
     },
     "defaults.job_attachments_file_system": {
         "default": "COPIED",
-        "depend": "defaults.farm_id",
+        "depend": _SETTING_FARM_ID,
         "description": "The file system mode to use for job attachments when running jobs. COPIED means to download a copy of the attachment data, VIRTUAL means to use a virtual file system for lazy loading.",
     },
     "settings.s3_max_pool_connections": {
diff --git a/src/deadline/client/ui/dialogs/submit_job_to_deadline_dialog.py b/src/deadline/client/ui/dialogs/submit_job_to_deadline_dialog.py
index 2bd2bba9a..c2c707e55 100644
--- a/src/deadline/client/ui/dialogs/submit_job_to_deadline_dialog.py
+++ b/src/deadline/client/ui/dialogs/submit_job_to_deadline_dialog.py
@@ -9,10 +9,11 @@
 import os
 import sys
 import json
+import threading as _threading
 from typing import Any, Dict, Optional, Protocol
 import yaml
 
-from qtpy.QtCore import QSize, Qt  # pylint: disable=import-error
+from qtpy.QtCore import QSize, Qt, Signal as _Signal  # pylint: disable=import-error
 from qtpy.QtGui import QKeyEvent  # pylint: disable=import-error
 from qtpy.QtWidgets import (  # pylint: disable=import-error; type: ignore
     QApplication,
@@ -36,6 +37,8 @@
 from ..deadline_authentication_status import DeadlineAuthenticationStatus
 from .._utils import block_signals, tr
 from ...config import get_setting, set_setting, config_file
+from ...config.config_file import _SETTING_FARM_ID
+from ...config.config_file import _SETTING_QUEUE_ID
 from ...exceptions import UserInitiatedCancel, NonValidInputError
 from ...job_bundle import create_job_history_bundle_dir
 from ...job_bundle.parameters import JobParameter
@@ -104,6 +107,8 @@ class SubmitJobToDeadlineDialog(QDialog):
         submitter_info (SubmitterInfo): Information related to the submitter window and application it's running in
     """
 
+    _auto_select_complete = _Signal()
+
     def __init__(
         self,
         *,
@@ -229,6 +234,7 @@ def _build_ui(
         self.deadline_authentication_status.api_availability_changed.connect(
             self.refresh_deadline_settings
         )
+        self._auto_select_complete.connect(self.refresh_deadline_settings)
 
         # Refresh the submit button enable state once queue parameter status changes
         self.shared_job_settings.valid_parameters.connect(self._set_submit_button_state)
@@ -257,8 +263,8 @@ def _set_submit_button_state(self):
         # Enable/disable the Submit button based on whether the
         # AWS Deadline Cloud API is accessible and the farm+queue are configured.
         api_available = self.deadline_authentication_status.api_availability is True
-        farm_configured = get_setting("defaults.farm_id") != ""
-        queue_configured = get_setting("defaults.queue_id") != ""
+        farm_configured = get_setting(_SETTING_FARM_ID) != ""
+        queue_configured = get_setting(_SETTING_QUEUE_ID) != ""
         queue_valid = self.shared_job_settings.is_queue_valid()
 
         enable = api_available and farm_configured and queue_configured and queue_valid
@@ -295,6 +301,7 @@ def _set_submit_button_state(self):
             self.submit_button.setToolTip("")
 
     def refresh_deadline_settings(self):
+        self._auto_select_defaults()
         self._set_submit_button_state()
 
         self.shared_job_settings.deadline_cloud_settings_box.refresh_setting_controls(
@@ -303,6 +310,51 @@ def refresh_deadline_settings(self):
         # If necessary, this reloads the queue parameters
         self.shared_job_settings.refresh_queue_parameters()
 
+    def _auto_select_defaults(self):
+        """Auto-select farm/queue in a background thread if only one is available."""
+        if self.deadline_authentication_status.api_availability is not True:
+            return
+        if get_setting(_SETTING_FARM_ID) and get_setting(_SETTING_QUEUE_ID):
+            return
+        if getattr(self, "_auto_select_in_progress", False):
+            return
+        self._auto_select_in_progress = True
+
+        _threading.Thread(target=self._do_auto_select, daemon=True).start()
+
+    def _do_auto_select(self):
+        """Background worker that auto-selects farm/queue if only one exists."""
+        try:
+            farm_changed = self._try_auto_select_farm()
+            queue_changed = self._try_auto_select_queue()
+            if farm_changed or queue_changed:
+                self._auto_select_complete.emit()
+        except Exception:
+            logger.debug("Auto-select defaults failed", exc_info=True)
+        finally:
+            self._auto_select_in_progress = False
+
+    def _try_auto_select_farm(self) -> bool:
+        if get_setting(_SETTING_FARM_ID):
+            return False
+        farms = api.list_farms().get("farms", [])
+        if len(farms) == 1:
+            set_setting(_SETTING_FARM_ID, farms[0]["farmId"])
+            logger.info("Auto-selected farm: %s", farms[0]["farmId"])
+            return True
+        return False
+
+    def _try_auto_select_queue(self) -> bool:
+        if not get_setting(_SETTING_FARM_ID) or get_setting(_SETTING_QUEUE_ID):
+            return False
+        farm_id = get_setting(_SETTING_FARM_ID)
+        queues = api.list_queues(farmId=farm_id).get("queues", [])
+        if len(queues) == 1:
+            set_setting(_SETTING_QUEUE_ID, queues[0]["queueId"])
+            logger.info("Auto-selected queue: %s", queues[0]["queueId"])
+            return True
+        return False
+
     def keyPressEvent(self, event: QKeyEvent) -> None:
         """
         Override to capture any enter/return key presses so that the Submit
diff --git a/test/unit/deadline_client/cli/test_cli_common.py b/test/unit/deadline_client/cli/test_cli_common.py
index 3b514504c..1599bd0f6 100644
--- a/test/unit/deadline_client/cli/test_cli_common.py
+++ b/test/unit/deadline_client/cli/test_cli_common.py
@@ -1,12 +1,20 @@
 # Copyright Amazon.com, Inc. or its affiliates. All Rights Reserved.
 
 import json
+from unittest.mock import patch
+
 import pytest
 
 import click
 import yaml
 
-from deadline.client.cli._common import _parse_file_parameter, _parse_multi_format_parameters
+from deadline.client.cli._common import (
+    _auto_select_farm,
+    _auto_select_queue,
+    _parse_file_parameter,
+    _parse_multi_format_parameters,
+)
+from deadline.client.config import config_file
 
 
 class TestParseFileParameter:
@@ -282,3 +290,55 @@ def test_progress_bar_not_closed_at_zero(self):
 
         assert manager._bar_status == manager.BAR_CREATED
         manager._exit_stack.close()
+
+
+class TestAutoSelectFarm:
+    def test_single_farm_returns_id(self, fresh_deadline_config):
+        with patch("deadline.client.cli._common._api.list_farms") as mock_list:
+            mock_list.return_value = {"farms": [{"farmId": "farm-abc123"}]}
+            assert _auto_select_farm() == "farm-abc123"
+
+    def test_multiple_farms_returns_none(self, fresh_deadline_config):
+        with patch("deadline.client.cli._common._api.list_farms") as mock_list:
+            mock_list.return_value = {"farms": [{"farmId": "farm-1"}, {"farmId": "farm-2"}]}
+            assert _auto_select_farm() is None
+
+    def test_no_farms_returns_none(self, fresh_deadline_config):
+        with patch("deadline.client.cli._common._api.list_farms") as mock_list:
+            mock_list.return_value = {"farms": []}
+            assert _auto_select_farm() is None
+
+    def test_api_error_returns_none(self, fresh_deadline_config):
+        with patch("deadline.client.cli._common._api.list_farms") as mock_list:
+            mock_list.side_effect = Exception("API error")
+            assert _auto_select_farm() is None
+
+
+class TestAutoSelectQueue:
+    def test_single_queue_returns_id(self, fresh_deadline_config):
+        config_file.set_setting("defaults.farm_id", "farm-abc123")
+        with patch("deadline.client.cli._common._api.list_queues") as mock_list:
+            mock_list.return_value = {"queues": [{"queueId": "queue-xyz789"}]}
+            assert _auto_select_queue() == "queue-xyz789"
+            mock_list.assert_called_once_with(farmId="farm-abc123", config=None)
+
+    def test_multiple_queues_returns_none(self, fresh_deadline_config):
+        config_file.set_setting("defaults.farm_id", "farm-abc123")
+        with patch("deadline.client.cli._common._api.list_queues") as mock_list:
+            mock_list.return_value = {"queues": [{"queueId": "queue-1"}, {"queueId": "queue-2"}]}
+            assert _auto_select_queue() is None
+
+    def test_no_queues_returns_none(self, fresh_deadline_config):
+        config_file.set_setting("defaults.farm_id", "farm-abc123")
+        with patch("deadline.client.cli._common._api.list_queues") as mock_list:
+            mock_list.return_value = {"queues": []}
+            assert _auto_select_queue() is None
+
+    def test_no_farm_id_returns_none(self, fresh_deadline_config):
+        assert _auto_select_queue() is None
+
+    def test_api_error_returns_none(self, fresh_deadline_config):
+        config_file.set_setting("defaults.farm_id", "farm-abc123")
+        with patch("deadline.client.cli._common._api.list_queues") as mock_list:
+            mock_list.side_effect = Exception("API error")
+            assert _auto_select_queue() is None