Hi,
The guideline for clopidogrel and CYP2C19 for Poor Metabolizers, for cardiovascular indications (Table 2) recommends "Avoid clopidogrel if possible. Use prasugrel or ticagrelor at standard dose if no contraindication"
However, the database contains "Avoid standard dose (75 mg/day) clopidogrel if possible. Use prasugrel or ticagrelor at standard dose if no contraindication."
It's a small difference, but the first one conveys a stronger contraindication. I understand that sombody has manually curated the published guidelines. I would be interested to know if this was a typo, or maybe there's a new guideline I'm not aware of.
Thanks