[QUESTION] Recommendation lookup for CYP4F2

[davidyuyuan]

According to https://cpicpgx.org/guidelines/guideline-for-warfarin-and-cyp2c9-and-vkorc1/, CYP4F2 does not have a diplotype to phenotype table because this guideline’s recommendations are based on genotype and not phenotype, the diplotype-phenotype tables were not created for these genes.

Would the recommendation lookup API still working? If not, what's the recommended approach to lookup recommendations from star alleles?

We tried https://api.cpicpgx.org/v1/rpc/recommendation_lookup?diplotypelookup={"CYP4F2": {"*1": 1, "*5": 1}}&drugname=in.(acenocoumarol,phenprocoumon,warfarin)&order=drugname or other lookup keys for diplotypes of *1/*3, *1/*1, *1/*2, *1/*6 and *1/*7. The Json response was always empty '[]'.

Please advise. Thank you!

[davidyuyuan]

We have run into similar difficulties when we try to lookup the recommendations for VKORC1. The API call https://api.cpicpgx.org/v1/rpc/recommendation_lookup?diplotypelookup={"VKORC1": {"rs9923231 variant (T)": 1, "rs9923231 reference (C)": 1}}&drugname=in.(warfarin)&order=drugname returns an empty '[]' Json.
We also tried https://api.cpicpgx.org/v1/rpc/recommendation_lookup?diplotypelookup={%22VKORC1%22:%20{%22rs9923231%20reference%20(C)%22:%202}}&drugname=in.(warfarin)&order=drugname and got an empty Json as well.

Just FYI. https://cpicpgx.org/guidelines/guideline-for-warfarin-and-cyp2c9-and-vkorc1/ says VKORC1 does not have a diplotype to phenotype table because this guideline’s recommendations are based on genotype and not phenotype, the diplotype-phenotype tables were not created for these genes.