diff --git a/.gitignore b/.gitignore index ef85063..5ca3a76 100644 --- a/.gitignore +++ b/.gitignore @@ -2,4 +2,5 @@ .Rhistory .RData .sublime-project -.sublime-workspace \ No newline at end of file +.sublime-workspace +inst/doc diff --git a/DESCRIPTION b/DESCRIPTION index 108bba5..0d4dcf4 100644 --- a/DESCRIPTION +++ b/DESCRIPTION @@ -6,7 +6,8 @@ Date: 2014-01-01 Authors@R: c(person("Devin", "Pastoor", role = c("aut", "cre"), email = "devin.pastoor@gmail.com")) Suggests: - knitr + knitr, + rmarkdown VignetteBuilder: knitr Description: ctm-datasets provides a number of simulated datasets to provide pharmacokinetic, pharmacodynamic, and demographic data to allow for easy @@ -16,3 +17,4 @@ Description: ctm-datasets provides a number of simulated datasets to provide examples in pharmacometrics. LazyData: TRUE License: MIT +RoxygenNote: 6.0.1 diff --git a/NAMESPACE b/NAMESPACE index d03037d..df303c1 100644 --- a/NAMESPACE +++ b/NAMESPACE @@ -1,4 +1,4 @@ -# Generated by roxygen2 (4.1.0): do not edit by hand +# Generated by roxygen2: do not edit by hand export(list_datasets) export(print_datasets) diff --git a/README.Rmd b/README.Rmd new file mode 100644 index 0000000..fc754b0 --- /dev/null +++ b/README.Rmd @@ -0,0 +1,3 @@ +# README + +datasets for PKPD style usage diff --git a/docs/articles/index.html b/docs/articles/index.html new file mode 100644 index 0000000..500897e --- /dev/null +++ b/docs/articles/index.html @@ -0,0 +1,100 @@ + + + +
+ + + + +## Warning: package 'DiagrammeR' was built under R version 3.3.3
+A dataset containing simulated PKPD data. A single IV bolus dose was given and rich pharmacokinetic and pharmacodynamic measurements were taken. Demographic data of Age, Weight, Gender, and Race were collected.
+This data was simulated from a one-compartment model with first-order and elimination after a IV bolus dose. The table below shows the parameters used to simulate the dataset -
+| Parameter | +Mean | +Variance..BSV. | +
|---|---|---|
| CL (L/hr) | +1 | +0.16 (40%) | +
| V (L) | +10 | +0.09 (30%) | +
| Residual error: Proportional | +0 | +10% | +
| Emax | +10 | +sd = 1.4 units | +
| EC50 (mg/L) | +2 | +0.09 (30%) | +
| Residual Error on Effect | +0 | +sd = 0.5 units | +
Notes -
+\(CL\) can also be derived from \(k\), \(V\) where, \[ CL = k \times V\]
+The population values of \(CL\), \(TVCL\) is allometrically scaled as follows: \[ CL = TVCL \times (\frac{WEIGHT}{70})^{0.75} \]
+\[ Effect = \frac{Emax\times C_p(t)}{EC_{50} + C_p(t)} \]
+ +The model used is a one-compartment PK model with allometric model of weight on CL (exp 0.75) and volume (exp 1) with direct PD effect (Emax model).
+ID. Numerical ID (1-100)
TIME Time in hours (0-12)
COBS. Plasma concentration in ug/L
EOBS.
WEIGHT. Weight in kg
AGE. Age in years
DOSE. Three dose levels: 1, 10, and 100 mg
SEX. Male or Female gender identification
RACE. AfricanAmerican, Caucasian, Others, and Asian races
AMT. Amount of drug given, time dependent, in milligrams
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boxvh:"┼",boxvH:"╪",boxVh:"╫",boxVH:"╬",boxvl:"┤",boxvL:"╡",boxVl:"╢",boxVL:"╣",boxvr:"├",boxvR:"╞",boxVr:"╟",boxVR:"╠",bprime:"‵",breve:"˘",Breve:"˘",brvbar:"¦",bscr:"𝒷",Bscr:"ℬ",bsemi:"⁏",bsim:"∽",bsime:"⋍",bsolb:"⧅",bsol:"\\",bsolhsub:"⟈",bull:"•",bullet:"•",bump:"≎",bumpE:"⪮",bumpe:"≏",Bumpeq:"≎",bumpeq:"≏",Cacute:"Ć",cacute:"ć",capand:"⩄",capbrcup:"⩉",capcap:"⩋",cap:"∩",Cap:"⋒",capcup:"⩇",capdot:"⩀",CapitalDifferentialD:"ⅅ",caps:"∩︀",caret:"⁁",caron:"ˇ",Cayleys:"ℭ",ccaps:"⩍",Ccaron:"Č",ccaron:"č",Ccedil:"Ç",ccedil:"ç",Ccirc:"Ĉ",ccirc:"ĉ",Cconint:"∰",ccups:"⩌",ccupssm:"⩐",Cdot:"Ċ",cdot:"ċ",cedil:"¸",Cedilla:"¸",cemptyv:"⦲",cent:"¢",centerdot:"·",CenterDot:"·",cfr:"𝔠",Cfr:"ℭ",CHcy:"Ч",chcy:"ч",check:"✓",checkmark:"✓",Chi:"Χ",chi:"χ",circ:"ˆ",circeq:"≗",circlearrowleft:"↺",circlearrowright:"↻",circledast:"⊛",circledcirc:"⊚",circleddash:"⊝",CircleDot:"⊙",circledR:"®",circledS:"Ⓢ",CircleMinus:"⊖",CirclePlus:"⊕",CircleTimes:"⊗",cir:"○",cirE:"⧃",cire:"≗",cirfnint:"⨐",cirmid:"⫯",cirscir:"⧂",ClockwiseContourIntegral:"∲",CloseCurlyDoubleQuote:"”",CloseCurlyQuote:"’",clubs:"♣",clubsuit:"♣",colon:":",Colon:"∷",Colone:"⩴",colone:"≔",coloneq:"≔",comma:",",commat:"@",comp:"∁",compfn:"∘",complement:"∁",complexes:"ℂ",cong:"≅",congdot:"⩭",Congruent:"≡",conint:"∮",Conint:"∯",ContourIntegral:"∮",copf:"𝕔",Copf:"ℂ",coprod:"∐",Coproduct:"∐",copy:"©",COPY:"©",copysr:"℗",CounterClockwiseContourIntegral:"∳",crarr:"↵",cross:"✗",Cross:"⨯",Cscr:"𝒞",cscr:"𝒸",csub:"⫏",csube:"⫑",csup:"⫐",csupe:"⫒",ctdot:"⋯",cudarrl:"⤸",cudarrr:"⤵",cuepr:"⋞",cuesc:"⋟",cularr:"↶",cularrp:"⤽",cupbrcap:"⩈",cupcap:"⩆",CupCap:"≍",cup:"∪",Cup:"⋓",cupcup:"⩊",cupdot:"⊍",cupor:"⩅",cups:"∪︀",curarr:"↷",curarrm:"⤼",curlyeqprec:"⋞",curlyeqsucc:"⋟",curlyvee:"⋎",curlywedge:"⋏",curren:"¤",curvearrowleft:"↶",curvearrowright:"↷",cuvee:"⋎",cuwed:"⋏",cwconint:"∲",cwint:"∱",cylcty:"⌭",dagger:"†",Dagger:"‡",daleth:"ℸ",darr:"↓",Darr:"↡",dArr:"⇓",dash:"‐",Dashv:"⫤",dashv:"⊣",dbkarow:"⤏",dblac:"˝",Dcaron:"Ď",dcaron:"ď",Dcy:"Д",dcy:"д",ddagger:"‡",ddarr:"⇊",DD:"ⅅ",dd:"ⅆ",DDotrahd:"⤑",ddotseq:"⩷",deg:"°",Del:"∇",Delta:"Δ",delta:"δ",demptyv:"⦱",dfisht:"⥿",Dfr:"𝔇",dfr:"𝔡",dHar:"⥥",dharl:"⇃",dharr:"⇂",DiacriticalAcute:"´",DiacriticalDot:"˙",DiacriticalDoubleAcute:"˝",DiacriticalGrave:"`",DiacriticalTilde:"˜",diam:"⋄",diamond:"⋄",Diamond:"⋄",diamondsuit:"♦",diams:"♦",die:"¨",DifferentialD:"ⅆ",digamma:"ϝ",disin:"⋲",div:"÷",divide:"÷",divideontimes:"⋇",divonx:"⋇",DJcy:"Ђ",djcy:"ђ",dlcorn:"⌞",dlcrop:"⌍",dollar:"$",Dopf:"𝔻",dopf:"𝕕",Dot:"¨",dot:"˙",DotDot:"⃜",doteq:"≐",doteqdot:"≑",DotEqual:"≐",dotminus:"∸",dotplus:"∔",dotsquare:"⊡",doublebarwedge:"⌆",DoubleContourIntegral:"∯",DoubleDot:"¨",DoubleDownArrow:"⇓",DoubleLeftArrow:"⇐",DoubleLeftRightArrow:"⇔",DoubleLeftTee:"⫤",DoubleLongLeftArrow:"⟸",DoubleLongLeftRightArrow:"⟺",DoubleLongRightArrow:"⟹",DoubleRightArrow:"⇒",DoubleRightTee:"⊨",DoubleUpArrow:"⇑",DoubleUpDownArrow:"⇕",DoubleVerticalBar:"∥",DownArrowBar:"⤓",downarrow:"↓",DownArrow:"↓",Downarrow:"⇓",DownArrowUpArrow:"⇵",DownBreve:"̑",downdownarrows:"⇊",downharpoonleft:"⇃",downharpoonright:"⇂",DownLeftRightVector:"⥐",DownLeftTeeVector:"⥞",DownLeftVectorBar:"⥖",DownLeftVector:"↽",DownRightTeeVector:"⥟",DownRightVectorBar:"⥗",DownRightVector:"⇁",DownTeeArrow:"↧",DownTee:"⊤",drbkarow:"⤐",drcorn:"⌟",drcrop:"⌌",Dscr:"𝒟",dscr:"𝒹",DScy:"Ѕ",dscy:"ѕ",dsol:"⧶",Dstrok:"Đ",dstrok:"đ",dtdot:"⋱",dtri:"▿",dtrif:"▾",duarr:"⇵",duhar:"⥯",dwangle:"⦦",DZcy:"Џ",dzcy:"џ",dzigrarr:"⟿",Eacute:"É",eacute:"é",easter:"⩮",Ecaron:"Ě",ecaron:"ě",Ecirc:"Ê",ecirc:"ê",ecir:"≖",ecolon:"≕",Ecy:"Э",ecy:"э",eDDot:"⩷",Edot:"Ė",edot:"ė",eDot:"≑",ee:"ⅇ",efDot:"≒",Efr:"𝔈",efr:"𝔢",eg:"⪚",Egrave:"È",egrave:"è",egs:"⪖",egsdot:"⪘",el:"⪙",Element:"∈",elinters:"⏧",ell:"ℓ",els:"⪕",elsdot:"⪗",Emacr:"Ē",emacr:"ē",empty:"∅",emptyset:"∅",EmptySmallSquare:"◻",emptyv:"∅",EmptyVerySmallSquare:"▫",emsp13:" ",emsp14:" ",emsp:" ",ENG:"Ŋ",eng:"ŋ",ensp:" ",Eogon:"Ę",eogon:"ę",Eopf:"𝔼",eopf:"𝕖",epar:"⋕",eparsl:"⧣",eplus:"⩱",epsi:"ε",Epsilon:"Ε",epsilon:"ε",epsiv:"ϵ",eqcirc:"≖",eqcolon:"≕",eqsim:"≂",eqslantgtr:"⪖",eqslantless:"⪕",Equal:"⩵",equals:"=",EqualTilde:"≂",equest:"≟",Equilibrium:"⇌",equiv:"≡",equivDD:"⩸",eqvparsl:"⧥",erarr:"⥱",erDot:"≓",escr:"ℯ",Escr:"ℰ",esdot:"≐",Esim:"⩳",esim:"≂",Eta:"Η",eta:"η",ETH:"Ð",eth:"ð",Euml:"Ë",euml:"ë",euro:"€",excl:"!",exist:"∃",Exists:"∃",expectation:"ℰ",exponentiale:"ⅇ",ExponentialE:"ⅇ",fallingdotseq:"≒",Fcy:"Ф",fcy:"ф",female:"♀",ffilig:"ffi",fflig:"ff",ffllig:"ffl",Ffr:"𝔉",ffr:"𝔣",filig:"fi",FilledSmallSquare:"◼",FilledVerySmallSquare:"▪",fjlig:"fj",flat:"♭",fllig:"fl",fltns:"▱",fnof:"ƒ",Fopf:"𝔽",fopf:"𝕗",forall:"∀",ForAll:"∀",fork:"⋔",forkv:"⫙",Fouriertrf:"ℱ",fpartint:"⨍",frac12:"½",frac13:"⅓",frac14:"¼",frac15:"⅕",frac16:"⅙",frac18:"⅛",frac23:"⅔",frac25:"⅖",frac34:"¾",frac35:"⅗",frac38:"⅜",frac45:"⅘",frac56:"⅚",frac58:"⅝",frac78:"⅞",frasl:"⁄",frown:"⌢",fscr:"𝒻",Fscr:"ℱ",gacute:"ǵ",Gamma:"Γ",gamma:"γ",Gammad:"Ϝ",gammad:"ϝ",gap:"⪆",Gbreve:"Ğ",gbreve:"ğ",Gcedil:"Ģ",Gcirc:"Ĝ",gcirc:"ĝ",Gcy:"Г",gcy:"г",Gdot:"Ġ",gdot:"ġ",ge:"≥",gE:"≧",gEl:"⪌",gel:"⋛",geq:"≥",geqq:"≧",geqslant:"⩾",gescc:"⪩",ges:"⩾",gesdot:"⪀",gesdoto:"⪂",gesdotol:"⪄",gesl:"⋛︀",gesles:"⪔",Gfr:"𝔊",gfr:"𝔤",gg:"≫",Gg:"⋙",ggg:"⋙",gimel:"ℷ",GJcy:"Ѓ",gjcy:"ѓ",gla:"⪥",gl:"≷",glE:"⪒",glj:"⪤",gnap:"⪊",gnapprox:"⪊",gne:"⪈",gnE:"≩",gneq:"⪈",gneqq:"≩",gnsim:"⋧",Gopf:"𝔾",gopf:"𝕘",grave:"`",GreaterEqual:"≥",GreaterEqualLess:"⋛",GreaterFullEqual:"≧",GreaterGreater:"⪢",GreaterLess:"≷",GreaterSlantEqual:"⩾",GreaterTilde:"≳",Gscr:"𝒢",gscr:"ℊ",gsim:"≳",gsime:"⪎",gsiml:"⪐",gtcc:"⪧",gtcir:"⩺",gt:">",GT:">",Gt:"≫",gtdot:"⋗",gtlPar:"⦕",gtquest:"⩼",gtrapprox:"⪆",gtrarr:"⥸",gtrdot:"⋗",gtreqless:"⋛",gtreqqless:"⪌",gtrless:"≷",gtrsim:"≳",gvertneqq:"≩︀",gvnE:"≩︀",Hacek:"ˇ",hairsp:" ",half:"½",hamilt:"ℋ",HARDcy:"Ъ",hardcy:"ъ",harrcir:"⥈",harr:"↔",hArr:"⇔",harrw:"↭",Hat:"^",hbar:"ℏ",Hcirc:"Ĥ",hcirc:"ĥ",hearts:"♥",heartsuit:"♥",hellip:"…",hercon:"⊹",hfr:"𝔥",Hfr:"ℌ",HilbertSpace:"ℋ",hksearow:"⤥",hkswarow:"⤦",hoarr:"⇿",homtht:"∻",hookleftarrow:"↩",hookrightarrow:"↪",hopf:"𝕙",Hopf:"ℍ",horbar:"―",HorizontalLine:"─",hscr:"𝒽",Hscr:"ℋ",hslash:"ℏ",Hstrok:"Ħ",hstrok:"ħ",HumpDownHump:"≎",HumpEqual:"≏",hybull:"⁃",hyphen:"‐",Iacute:"Í",iacute:"í",ic:"",Icirc:"Î",icirc:"î",Icy:"И",icy:"и",Idot:"İ",IEcy:"Е",iecy:"е",iexcl:"¡",iff:"⇔",ifr:"𝔦",Ifr:"ℑ",Igrave:"Ì",igrave:"ì",ii:"ⅈ",iiiint:"⨌",iiint:"∭",iinfin:"⧜",iiota:"℩",IJlig:"IJ",ijlig:"ij",Imacr:"Ī",imacr:"ī",image:"ℑ",ImaginaryI:"ⅈ",imagline:"ℐ",imagpart:"ℑ",imath:"ı",Im:"ℑ",imof:"⊷",imped:"Ƶ",Implies:"⇒",incare:"℅","in":"∈",infin:"∞",infintie:"⧝",inodot:"ı",intcal:"⊺","int":"∫",Int:"∬",integers:"ℤ",Integral:"∫",intercal:"⊺",Intersection:"⋂",intlarhk:"⨗",intprod:"⨼",InvisibleComma:"",InvisibleTimes:"",IOcy:"Ё",iocy:"ё",Iogon:"Į",iogon:"į",Iopf:"𝕀",iopf:"𝕚",Iota:"Ι",iota:"ι",iprod:"⨼",iquest:"¿",iscr:"𝒾",Iscr:"ℐ",isin:"∈",isindot:"⋵",isinE:"⋹",isins:"⋴",isinsv:"⋳",isinv:"∈",it:"",Itilde:"Ĩ",itilde:"ĩ",Iukcy:"І",iukcy:"і",Iuml:"Ï",iuml:"ï",Jcirc:"Ĵ",jcirc:"ĵ",Jcy:"Й",jcy:"й",Jfr:"𝔍",jfr:"𝔧",jmath:"ȷ",Jopf:"𝕁",jopf:"𝕛",Jscr:"𝒥",jscr:"𝒿",Jsercy:"Ј",jsercy:"ј",Jukcy:"Є",jukcy:"є",Kappa:"Κ",kappa:"κ",kappav:"ϰ",Kcedil:"Ķ",kcedil:"ķ",Kcy:"К",kcy:"к",Kfr:"𝔎",kfr:"𝔨",kgreen:"ĸ",KHcy:"Х",khcy:"х",KJcy:"Ќ",kjcy:"ќ",Kopf:"𝕂",kopf:"𝕜",Kscr:"𝒦",kscr:"𝓀",lAarr:"⇚",Lacute:"Ĺ",lacute:"ĺ",laemptyv:"⦴",lagran:"ℒ",Lambda:"Λ",lambda:"λ",lang:"⟨",Lang:"⟪",langd:"⦑",langle:"⟨",lap:"⪅",Laplacetrf:"ℒ",laquo:"«",larrb:"⇤",larrbfs:"⤟",larr:"←",Larr:"↞",lArr:"⇐",larrfs:"⤝",larrhk:"↩",larrlp:"↫",larrpl:"⤹",larrsim:"⥳",larrtl:"↢",latail:"⤙",lAtail:"⤛",lat:"⪫",late:"⪭",lates:"⪭︀",lbarr:"⤌",lBarr:"⤎",lbbrk:"❲",lbrace:"{",lbrack:"[",lbrke:"⦋",lbrksld:"⦏",lbrkslu:"⦍",Lcaron:"Ľ",lcaron:"ľ",Lcedil:"Ļ",lcedil:"ļ",lceil:"⌈",lcub:"{",Lcy:"Л",lcy:"л",ldca:"⤶",ldquo:"“",ldquor:"„",ldrdhar:"⥧",ldrushar:"⥋",ldsh:"↲",le:"≤",lE:"≦",LeftAngleBracket:"⟨",LeftArrowBar:"⇤",leftarrow:"←",LeftArrow:"←",Leftarrow:"⇐",LeftArrowRightArrow:"⇆",leftarrowtail:"↢",LeftCeiling:"⌈",LeftDoubleBracket:"⟦",LeftDownTeeVector:"⥡",LeftDownVectorBar:"⥙",LeftDownVector:"⇃",LeftFloor:"⌊",leftharpoondown:"↽",leftharpoonup:"↼",leftleftarrows:"⇇",leftrightarrow:"↔",LeftRightArrow:"↔",Leftrightarrow:"⇔",leftrightarrows:"⇆",leftrightharpoons:"⇋",leftrightsquigarrow:"↭",LeftRightVector:"⥎",LeftTeeArrow:"↤",LeftTee:"⊣",LeftTeeVector:"⥚",leftthreetimes:"⋋",LeftTriangleBar:"⧏",LeftTriangle:"⊲",LeftTriangleEqual:"⊴",LeftUpDownVector:"⥑",LeftUpTeeVector:"⥠",LeftUpVectorBar:"⥘",LeftUpVector:"↿",LeftVectorBar:"⥒",LeftVector:"↼",lEg:"⪋",leg:"⋚",leq:"≤",leqq:"≦",leqslant:"⩽",lescc:"⪨",les:"⩽",lesdot:"⩿",lesdoto:"⪁",lesdotor:"⪃",lesg:"⋚︀",lesges:"⪓",lessapprox:"⪅",lessdot:"⋖",lesseqgtr:"⋚",lesseqqgtr:"⪋",LessEqualGreater:"⋚",LessFullEqual:"≦",LessGreater:"≶",lessgtr:"≶",LessLess:"⪡",lesssim:"≲",LessSlantEqual:"⩽",LessTilde:"≲",lfisht:"⥼",lfloor:"⌊",Lfr:"𝔏",lfr:"𝔩",lg:"≶",lgE:"⪑",lHar:"⥢",lhard:"↽",lharu:"↼",lharul:"⥪",lhblk:"▄",LJcy:"Љ",ljcy:"љ",llarr:"⇇",ll:"≪",Ll:"⋘",llcorner:"⌞",Lleftarrow:"⇚",llhard:"⥫",lltri:"◺",Lmidot:"Ŀ",lmidot:"ŀ",lmoustache:"⎰",lmoust:"⎰",lnap:"⪉",lnapprox:"⪉",lne:"⪇",lnE:"≨",lneq:"⪇",lneqq:"≨",lnsim:"⋦",loang:"⟬",loarr:"⇽",lobrk:"⟦",longleftarrow:"⟵",LongLeftArrow:"⟵",Longleftarrow:"⟸",longleftrightarrow:"⟷",LongLeftRightArrow:"⟷",Longleftrightarrow:"⟺",longmapsto:"⟼",longrightarrow:"⟶",LongRightArrow:"⟶",Longrightarrow:"⟹",looparrowleft:"↫",looparrowright:"↬",lopar:"⦅",Lopf:"𝕃",lopf:"𝕝",loplus:"⨭",lotimes:"⨴",lowast:"∗",lowbar:"_",LowerLeftArrow:"↙",LowerRightArrow:"↘",loz:"◊",lozenge:"◊",lozf:"⧫",lpar:"(",lparlt:"⦓",lrarr:"⇆",lrcorner:"⌟",lrhar:"⇋",lrhard:"⥭",lrm:"",lrtri:"⊿",lsaquo:"‹",lscr:"𝓁",Lscr:"ℒ",lsh:"↰",Lsh:"↰",lsim:"≲",lsime:"⪍",lsimg:"⪏",lsqb:"[",lsquo:"‘",lsquor:"‚",Lstrok:"Ł",lstrok:"ł",ltcc:"⪦",ltcir:"⩹",lt:"<",LT:"<",Lt:"≪",ltdot:"⋖",lthree:"⋋",ltimes:"⋉",ltlarr:"⥶",ltquest:"⩻",ltri:"◃",ltrie:"⊴",ltrif:"◂",ltrPar:"⦖",lurdshar:"⥊",luruhar:"⥦",lvertneqq:"≨︀",lvnE:"≨︀",macr:"¯",male:"♂",malt:"✠",maltese:"✠",Map:"⤅",map:"↦",mapsto:"↦",mapstodown:"↧",mapstoleft:"↤",mapstoup:"↥",marker:"▮",mcomma:"⨩",Mcy:"М",mcy:"м",mdash:"—",mDDot:"∺",measuredangle:"∡",MediumSpace:" ",Mellintrf:"ℳ",Mfr:"𝔐",mfr:"𝔪",mho:"℧",micro:"µ",midast:"*",midcir:"⫰",mid:"∣",middot:"·",minusb:"⊟",minus:"−",minusd:"∸",minusdu:"⨪",MinusPlus:"∓",mlcp:"⫛",mldr:"…",mnplus:"∓",models:"⊧",Mopf:"𝕄",mopf:"𝕞",mp:"∓",mscr:"𝓂",Mscr:"ℳ",mstpos:"∾",Mu:"Μ",mu:"μ",multimap:"⊸",mumap:"⊸",nabla:"∇",Nacute:"Ń",nacute:"ń",nang:"∠⃒",nap:"≉",napE:"⩰̸",napid:"≋̸",napos:"ʼn",napprox:"≉",natural:"♮",naturals:"ℕ",natur:"♮",nbsp:" ",nbump:"≎̸",nbumpe:"≏̸",ncap:"⩃",Ncaron:"Ň",ncaron:"ň",Ncedil:"Ņ",ncedil:"ņ",ncong:"≇",ncongdot:"⩭̸",ncup:"⩂",Ncy:"Н",ncy:"н",ndash:"–",nearhk:"⤤",nearr:"↗",neArr:"⇗",nearrow:"↗",ne:"≠",nedot:"≐̸",NegativeMediumSpace:"",NegativeThickSpace:"",NegativeThinSpace:"",NegativeVeryThinSpace:"",nequiv:"≢",nesear:"⤨",nesim:"≂̸",NestedGreaterGreater:"≫",NestedLessLess:"≪",NewLine:"\n",nexist:"∄",nexists:"∄",Nfr:"𝔑",nfr:"𝔫",ngE:"≧̸",nge:"≱",ngeq:"≱",ngeqq:"≧̸",ngeqslant:"⩾̸",nges:"⩾̸",nGg:"⋙̸",ngsim:"≵",nGt:"≫⃒",ngt:"≯",ngtr:"≯",nGtv:"≫̸",nharr:"↮",nhArr:"⇎",nhpar:"⫲",ni:"∋",nis:"⋼",nisd:"⋺",niv:"∋",NJcy:"Њ",njcy:"њ",nlarr:"↚",nlArr:"⇍",nldr:"‥",nlE:"≦̸",nle:"≰",nleftarrow:"↚",nLeftarrow:"⇍",nleftrightarrow:"↮",nLeftrightarrow:"⇎",nleq:"≰",nleqq:"≦̸",nleqslant:"⩽̸",nles:"⩽̸",nless:"≮",nLl:"⋘̸",nlsim:"≴",nLt:"≪⃒",nlt:"≮",nltri:"⋪",nltrie:"⋬",nLtv:"≪̸",nmid:"∤",NoBreak:"",NonBreakingSpace:" ",nopf:"𝕟",Nopf:"ℕ",Not:"⫬",not:"¬",NotCongruent:"≢",NotCupCap:"≭",NotDoubleVerticalBar:"∦",NotElement:"∉",NotEqual:"≠",NotEqualTilde:"≂̸",NotExists:"∄",NotGreater:"≯",NotGreaterEqual:"≱",NotGreaterFullEqual:"≧̸",NotGreaterGreater:"≫̸",NotGreaterLess:"≹",NotGreaterSlantEqual:"⩾̸",NotGreaterTilde:"≵",NotHumpDownHump:"≎̸",NotHumpEqual:"≏̸",notin:"∉",notindot:"⋵̸",notinE:"⋹̸",notinva:"∉",notinvb:"⋷",notinvc:"⋶",NotLeftTriangleBar:"⧏̸",NotLeftTriangle:"⋪",NotLeftTriangleEqual:"⋬",NotLess:"≮",NotLessEqual:"≰",NotLessGreater:"≸",NotLessLess:"≪̸",NotLessSlantEqual:"⩽̸",NotLessTilde:"≴",NotNestedGreaterGreater:"⪢̸",NotNestedLessLess:"⪡̸",notni:"∌",notniva:"∌",notnivb:"⋾",notnivc:"⋽",NotPrecedes:"⊀",NotPrecedesEqual:"⪯̸",NotPrecedesSlantEqual:"⋠",NotReverseElement:"∌",NotRightTriangleBar:"⧐̸",NotRightTriangle:"⋫",NotRightTriangleEqual:"⋭",NotSquareSubset:"⊏̸",NotSquareSubsetEqual:"⋢",NotSquareSuperset:"⊐̸",NotSquareSupersetEqual:"⋣",NotSubset:"⊂⃒",NotSubsetEqual:"⊈",NotSucceeds:"⊁",NotSucceedsEqual:"⪰̸",NotSucceedsSlantEqual:"⋡",NotSucceedsTilde:"≿̸",NotSuperset:"⊃⃒",NotSupersetEqual:"⊉",NotTilde:"≁",NotTildeEqual:"≄",NotTildeFullEqual:"≇",NotTildeTilde:"≉",NotVerticalBar:"∤",nparallel:"∦",npar:"∦",nparsl:"⫽⃥",npart:"∂̸",npolint:"⨔",npr:"⊀",nprcue:"⋠",nprec:"⊀",npreceq:"⪯̸",npre:"⪯̸",nrarrc:"⤳̸",nrarr:"↛",nrArr:"⇏",nrarrw:"↝̸",nrightarrow:"↛",nRightarrow:"⇏",nrtri:"⋫",nrtrie:"⋭",nsc:"⊁",nsccue:"⋡",nsce:"⪰̸",Nscr:"𝒩",nscr:"𝓃",nshortmid:"∤",nshortparallel:"∦",nsim:"≁",nsime:"≄",nsimeq:"≄",nsmid:"∤",nspar:"∦",nsqsube:"⋢",nsqsupe:"⋣",nsub:"⊄",nsubE:"⫅̸",nsube:"⊈",nsubset:"⊂⃒",nsubseteq:"⊈",nsubseteqq:"⫅̸",nsucc:"⊁",nsucceq:"⪰̸",nsup:"⊅",nsupE:"⫆̸",nsupe:"⊉",nsupset:"⊃⃒",nsupseteq:"⊉",nsupseteqq:"⫆̸",ntgl:"≹",Ntilde:"Ñ",ntilde:"ñ",ntlg:"≸",ntriangleleft:"⋪",ntrianglelefteq:"⋬",ntriangleright:"⋫",ntrianglerighteq:"⋭",Nu:"Ν",nu:"ν",num:"#",numero:"№",numsp:" ",nvap:"≍⃒",nvdash:"⊬",nvDash:"⊭",nVdash:"⊮",nVDash:"⊯",nvge:"≥⃒",nvgt:">⃒",nvHarr:"⤄",nvinfin:"⧞",nvlArr:"⤂",nvle:"≤⃒",nvlt:"<⃒",nvltrie:"⊴⃒",nvrArr:"⤃",nvrtrie:"⊵⃒",nvsim:"∼⃒",nwarhk:"⤣",nwarr:"↖",nwArr:"⇖",nwarrow:"↖",nwnear:"⤧",Oacute:"Ó",oacute:"ó",oast:"⊛",Ocirc:"Ô",ocirc:"ô",ocir:"⊚",Ocy:"О",ocy:"о",odash:"⊝",Odblac:"Ő",odblac:"ő",odiv:"⨸",odot:"⊙",odsold:"⦼",OElig:"Œ",oelig:"œ",ofcir:"⦿",Ofr:"𝔒",ofr:"𝔬",ogon:"˛",Ograve:"Ò",ograve:"ò",ogt:"⧁",ohbar:"⦵",ohm:"Ω",oint:"∮",olarr:"↺",olcir:"⦾",olcross:"⦻",oline:"‾",olt:"⧀",Omacr:"Ō",omacr:"ō",Omega:"Ω",omega:"ω",Omicron:"Ο",omicron:"ο",omid:"⦶",ominus:"⊖",Oopf:"𝕆",oopf:"𝕠",opar:"⦷",OpenCurlyDoubleQuote:"“",OpenCurlyQuote:"‘",operp:"⦹",oplus:"⊕",orarr:"↻",Or:"⩔",or:"∨",ord:"⩝",order:"ℴ",orderof:"ℴ",ordf:"ª",ordm:"º",origof:"⊶",oror:"⩖",orslope:"⩗",orv:"⩛",oS:"Ⓢ",Oscr:"𝒪",oscr:"ℴ",Oslash:"Ø",oslash:"ø",osol:"⊘",Otilde:"Õ",otilde:"õ",otimesas:"⨶",Otimes:"⨷",otimes:"⊗",Ouml:"Ö",ouml:"ö",ovbar:"⌽",OverBar:"‾",OverBrace:"⏞",OverBracket:"⎴",OverParenthesis:"⏜",para:"¶",parallel:"∥",par:"∥",parsim:"⫳",parsl:"⫽",part:"∂",PartialD:"∂",Pcy:"П",pcy:"п",percnt:"%",period:".",permil:"‰",perp:"⊥",pertenk:"‱",Pfr:"𝔓",pfr:"𝔭",Phi:"Φ",phi:"φ",phiv:"ϕ",phmmat:"ℳ",phone:"☎",Pi:"Π",pi:"π",pitchfork:"⋔",piv:"ϖ",planck:"ℏ",planckh:"ℎ",plankv:"ℏ",plusacir:"⨣",plusb:"⊞",pluscir:"⨢",plus:"+",plusdo:"∔",plusdu:"⨥",pluse:"⩲",PlusMinus:"±",plusmn:"±",plussim:"⨦",plustwo:"⨧",pm:"±",Poincareplane:"ℌ",pointint:"⨕",popf:"𝕡",Popf:"ℙ",pound:"£",prap:"⪷",Pr:"⪻",pr:"≺",prcue:"≼",precapprox:"⪷",prec:"≺",preccurlyeq:"≼",Precedes:"≺",PrecedesEqual:"⪯",PrecedesSlantEqual:"≼",PrecedesTilde:"≾",preceq:"⪯",precnapprox:"⪹",precneqq:"⪵",precnsim:"⋨",pre:"⪯",prE:"⪳",precsim:"≾",prime:"′",Prime:"″",primes:"ℙ",prnap:"⪹",prnE:"⪵",prnsim:"⋨",prod:"∏",Product:"∏",profalar:"⌮",profline:"⌒",profsurf:"⌓",prop:"∝",Proportional:"∝",Proportion:"∷",propto:"∝",prsim:"≾",prurel:"⊰",Pscr:"𝒫",pscr:"𝓅",Psi:"Ψ",psi:"ψ",puncsp:" ",Qfr:"𝔔",qfr:"𝔮",qint:"⨌",qopf:"𝕢",Qopf:"ℚ",qprime:"⁗",Qscr:"𝒬",qscr:"𝓆",quaternions:"ℍ",quatint:"⨖",quest:"?",questeq:"≟",quot:'"',QUOT:'"',rAarr:"⇛",race:"∽̱",Racute:"Ŕ",racute:"ŕ",radic:"√",raemptyv:"⦳",rang:"⟩",Rang:"⟫",rangd:"⦒",range:"⦥",rangle:"⟩",raquo:"»",rarrap:"⥵",rarrb:"⇥",rarrbfs:"⤠",rarrc:"⤳",rarr:"→",Rarr:"↠",rArr:"⇒",rarrfs:"⤞",rarrhk:"↪",rarrlp:"↬",rarrpl:"⥅",rarrsim:"⥴",Rarrtl:"⤖",rarrtl:"↣",rarrw:"↝",ratail:"⤚",rAtail:"⤜",ratio:"∶",rationals:"ℚ",rbarr:"⤍",rBarr:"⤏",RBarr:"⤐",rbbrk:"❳",rbrace:"}",rbrack:"]",rbrke:"⦌",rbrksld:"⦎",rbrkslu:"⦐",Rcaron:"Ř",rcaron:"ř",Rcedil:"Ŗ",rcedil:"ŗ",
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this.yylloc={first_line:this.yylloc.first_line,last_line:this.yylineno+1,first_column:this.yylloc.first_column,last_column:r?(r.length===n.length?this.yylloc.first_column:0)+n[n.length-r.length].length-r[0].length:this.yylloc.first_column-e},this.options.ranges&&(this.yylloc.range=[i[0],i[0]+this.yyleng-e]),this.yyleng=this.yytext.length,this},more:function(){return this._more=!0,this},reject:function(){return this.options.backtrack_lexer?(this._backtrack=!0,this):this.parseError("Lexical error on line "+(this.yylineno+1)+". 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+
+ 2017-05-04
+
+ Theophylline
+
+
+
+
+
+
+
+
+
+
\[ AUC = \int\limits_0^\infty C_p\, \mathrm{d}t\]
+
+ Data Structure
+
+
+0;h--)o.push(i(l)*h);for(l=0;o[l]c;s--);o=o.slice(l,s)}return o},o.tickFormat=function(n,t){if(!arguments.length)return wl;arguments.length<2?t=wl:"function"!=typeof t&&(t=ta.format(t));var r,a=Math.max(.1,n/o.ticks().length),c=e?(r=1e-12,Math.ceil):(r=-1e-12,Math.floor);return function(n){return n/i(c(u(n)+r))<=a?t(n):""}},o.copy=function(){return Ji(n.copy(),t,e,r)},Ii(o,n)}function Gi(n,t,e){function r(t){return n(u(t))}var u=Ki(t),i=Ki(1/t);return r.invert=function(t){return i(n.invert(t))},r.domain=function(t){return arguments.length?(n.domain((e=t.map(Number)).map(u)),r):e},r.ticks=function(n){return Xi(e,n)},r.tickFormat=function(n,t){return $i(e,n,t)},r.nice=function(n){return r.domain(Zi(e,n))},r.exponent=function(o){return arguments.length?(u=Ki(t=o),i=Ki(1/t),n.domain(e.map(u)),r):t},r.copy=function(){return Gi(n.copy(),t,e)},Ii(r,n)}function Ki(n){return function(t){return 0>t?-Math.pow(-t,n):Math.pow(t,n)}}function Qi(n,t){function e(e){return i[((u.get(e)||("range"===t.t?u.set(e,n.push(e)):0/0))-1)%i.length]}function r(t,e){return ta.range(n.length).map(function(n){return t+e*n})}var u,i,o;return e.domain=function(r){if(!arguments.length)return n;n=[],u=new a;for(var i,o=-1,c=r.length;++o