From f419fa14872bab0189de8ae0083d796824acf71c Mon Sep 17 00:00:00 2001 From: Zak King Date: Wed, 17 Apr 2019 11:44:51 -0700 Subject: [PATCH 1/3] copied maps v5 into maps v6 --- 1-0-0/6/maps/Escherichia coli/e_coli_core.Core metabolism.json | 1 + 1-0-0/6/maps/Escherichia coli/iJO1366.Central metabolism.json | 1 + .../maps/Escherichia coli/iJO1366.Fatty acid beta-oxidation.json | 1 + .../iJO1366.Fatty acid biosynthesis (saturated).json | 1 + .../iJO1366.Nucleotide and histidine biosynthesis.json | 1 + 1-0-0/6/maps/Escherichia coli/iJO1366.Nucleotide metabolism.json | 1 + .../Homo sapiens/RECON1.Amino acid metabolism (partial).json | 1 + 1-0-0/6/maps/Homo sapiens/RECON1.Carbohydrate metabolism.json | 1 + 1-0-0/6/maps/Homo sapiens/RECON1.Glycolysis TCA PPP.json | 1 + .../6/maps/Homo sapiens/RECON1.Inositol retinol metabolism.json | 1 + 1-0-0/6/maps/Homo sapiens/RECON1.Tryptophan metabolism.json | 1 + .../iMM904.Central carbon metabolism.json | 1 + 1-0-0/6/models/Escherichia coli/e_coli_core.json | 1 + 1-0-0/6/models/Escherichia coli/iJO1366.json | 1 + 1-0-0/6/models/Homo sapiens/RECON1.json | 1 + 1-0-0/6/models/Saccharomyces cerevisiae/iMM904.json | 1 + 16 files changed, 16 insertions(+) create mode 100644 1-0-0/6/maps/Escherichia coli/e_coli_core.Core metabolism.json create mode 100644 1-0-0/6/maps/Escherichia coli/iJO1366.Central metabolism.json create mode 100644 1-0-0/6/maps/Escherichia coli/iJO1366.Fatty acid beta-oxidation.json create mode 100644 1-0-0/6/maps/Escherichia coli/iJO1366.Fatty acid biosynthesis (saturated).json create mode 100644 1-0-0/6/maps/Escherichia coli/iJO1366.Nucleotide and histidine biosynthesis.json create mode 100644 1-0-0/6/maps/Escherichia coli/iJO1366.Nucleotide metabolism.json create mode 100644 1-0-0/6/maps/Homo sapiens/RECON1.Amino acid metabolism (partial).json create mode 100644 1-0-0/6/maps/Homo sapiens/RECON1.Carbohydrate metabolism.json create mode 100644 1-0-0/6/maps/Homo sapiens/RECON1.Glycolysis TCA PPP.json 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"gene_reaction_rule": ""}, {"subsystem": "Transport, Inner Membrane", "name": "1,2 diacylglycerol transport via flipping (periplasm to cytoplasm, n-C18:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["12DGR180tipp"]}, "metabolites": {"12dgr180_c": 1.0, "12dgr180_p": -1.0}, "id": "12DGR180tipp", "gene_reaction_rule": ""}, {"subsystem": "Transport, Inner Membrane", "name": "1,2 diacylglycerol transport via flipping (periplasm to cytoplasm, n-C18:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["12DGR181tipp"]}, "metabolites": {"12dgr181_c": 1.0, "12dgr181_p": -1.0}, "id": "12DGR181tipp", "gene_reaction_rule": ""}, {"subsystem": "Transport, Outer Membrane Porin", "name": "(R)-Propane-1,2-diol transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["12PPDRtex"]}, "metabolites": {"12ppd__R_e": -1.0, "12ppd__R_p": 1.0}, "id": "12PPDRtex", 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"12PPDStpp", "gene_reaction_rule": ""}, {"subsystem": "Transport, Inner Membrane", "name": "1,4-alpha-D-glucan transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["14GLUCANabcpp"]}, "metabolites": {"14glucan_p": -1.0, "h2o_c": -1.0, "atp_c": -1.0, "14glucan_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0}, "id": "14GLUCANabcpp", "gene_reaction_rule": "b4034 and b4033 and b4032 and b4035"}, {"subsystem": "Transport, Outer Membrane", "name": "1,4-alpha-D-glucan transport via diffusion (extracellular to periplasm) irreversible", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["14GLUCANtexi"]}, "metabolites": {"14glucan_p": 1.0, "14glucan_e": -1.0}, "id": "14GLUCANtexi", "gene_reaction_rule": "b4036"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "23cAMP transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["23CAMPtex"]}, "metabolites": {"23camp_e": -1.0, "23camp_p": 1.0}, "id": "23CAMPtex", "gene_reaction_rule": "b0241 or b0929 or b1377 or b2215"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "23cCMP transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["23CCMPtex"]}, "metabolites": {"23ccmp_e": -1.0, "23ccmp_p": 1.0}, "id": "23CCMPtex", "gene_reaction_rule": "b0241 or b0929 or b1377 or b2215"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "23cGMP transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["23CGMPtex"]}, "metabolites": {"23cgmp_p": 1.0, "23cgmp_e": -1.0}, "id": "23CGMPtex", "gene_reaction_rule": "b0241 or b0929 or b1377 or b2215"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "23cUMP transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, 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"2-Acyl-sn-glycero-3-phosphatidate (n-C16:1) transporter via facilitated diffusion (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["2AGPA161tipp"]}, "metabolites": {"2hdec9eg3p_c": 1.0, "2hdec9eg3p_p": -1.0}, "id": "2AGPA161tipp", "gene_reaction_rule": "b2835"}, {"subsystem": "Transport, Inner Membrane", "name": "2-Acyl-sn-glycero-3-phosphatidate (n-C18:0) transporter via facilitated diffusion (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["2AGPA180tipp"]}, "metabolites": {"2odecg3p_p": -1.0, "2odecg3p_c": 1.0}, "id": "2AGPA180tipp", "gene_reaction_rule": "b2835"}, {"subsystem": "Transport, Inner Membrane", "name": "2-Acyl-sn-glycero-3-phosphatidate (n-C18:1) transporter via facilitated diffusion (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["2AGPA181tipp"]}, "metabolites": {"2odec11eg3p_p": -1.0, "2odec11eg3p_c": 1.0}, "id": "2AGPA181tipp", 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"b2663"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "4-aminobutyrate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ABUTtex"]}, "metabolites": {"4abut_e": -1.0, "4abut_p": 1.0}, "id": "ABUTtex", "gene_reaction_rule": "b0241 or b0929 or b1377 or b2215"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Acetyl-CoA:acetoacetyl-CoA transferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ACACCT"]}, "metabolites": {"acac_c": -1.0, "aacoa_c": 1.0, "ac_c": 1.0, "accoa_c": -1.0}, "id": "ACACCT", "gene_reaction_rule": "b2221 and b2222"}, {"subsystem": "Membrane Lipid Metabolism", "name": "Acetyl-CoA C-acetyltransferase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACACT1r"]}, "metabolites": {"aacoa_c": 1.0, "coa_c": 1.0, "accoa_c": -2.0}, "id": "ACACT1r", "gene_reaction_rule": "b2224 or b2342 or b3845"}, {"subsystem": "Membrane Lipid Metabolism", "name": "Acetyl-CoA C-acyltransferase (butanoyl-CoA) (r)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACACT2r"]}, "metabolites": {"btcoa_c": -1.0, "coa_c": 1.0, "accoa_c": -1.0, "3ohcoa_c": 1.0}, "id": "ACACT2r", "gene_reaction_rule": "b2342 or b3845"}, {"subsystem": "Membrane Lipid Metabolism", "name": "Acetyl-CoA C-acyltransferase (hexanoyl-CoA) (r)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACACT3r"]}, "metabolites": {"3oocoa_c": 1.0, "coa_c": 1.0, "accoa_c": -1.0, "hxcoa_c": -1.0}, "id": "ACACT3r", "gene_reaction_rule": "b2342 or b3845"}, {"subsystem": "Membrane Lipid Metabolism", "name": "Acetyl-CoA C-acyltransferase (octanoyl-CoA) (r)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACACT4r"]}, "metabolites": {"coa_c": 1.0, "3odcoa_c": 1.0, "occoa_c": -1.0, "accoa_c": -1.0}, "id": "ACACT4r", "gene_reaction_rule": "b2342 or b3845"}, {"subsystem": "Membrane Lipid Metabolism", "name": "Acetyl-CoA C-acyltransferase (decanoyl-CoA) (r)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACACT5r"]}, "metabolites": {"3oddcoa_c": 1.0, "coa_c": 1.0, "dcacoa_c": -1.0, "accoa_c": -1.0}, "id": "ACACT5r", "gene_reaction_rule": "b2342 or b3845"}, {"subsystem": "Membrane Lipid Metabolism", "name": "Acetyl-CoA C-acyltransferase (dodecanoyl-CoA) (r)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACACT6r"]}, "metabolites": {"ddcacoa_c": -1.0, "3otdcoa_c": 1.0, "coa_c": 1.0, "accoa_c": -1.0}, "id": "ACACT6r", "gene_reaction_rule": "b2342 or b3845"}, {"subsystem": "Membrane Lipid Metabolism", "name": "Acetyl-CoA C-acyltransferase (tetradecanoyl-CoA) (r)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACACT7r"]}, "metabolites": {"coa_c": 1.0, "accoa_c": -1.0, "tdcoa_c": -1.0, "3ohdcoa_c": 1.0}, "id": "ACACT7r", "gene_reaction_rule": "b2342 or b3845"}, {"subsystem": "Membrane Lipid Metabolism", "name": "Acetyl-CoA acyltransferase (hexadecanoyl-CoA), (r)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACACT8r"]}, "metabolites": {"pmtcoa_c": 1.0, "3oodcoa_c": -1.0, "coa_c": -1.0, "accoa_c": 1.0}, "id": "ACACT8r", "gene_reaction_rule": "b2342 or b3845"}, {"subsystem": "Transport, Inner Membrane", "name": "Acetoacetate transport via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACACt2pp"]}, "metabolites": {"acac_c": 1.0, "acac_p": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "ACACt2pp", "gene_reaction_rule": "b2223"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Acetoacetate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACACtex"]}, "metabolites": {"acac_p": 1.0, "acac_e": -1.0}, "id": "ACACtex", "gene_reaction_rule": "b0241 or 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"s0001"}, {"subsystem": "Tyrosine, Tryptophan, and Phenylalanine Metabolism", "name": "Acetyl-CoA:anthranilate acetyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ACANTHAT"]}, "metabolites": {"anth_c": -1.0, "coa_c": 1.0, "accoa_c": -1.0, "acanth_c": 1.0}, "id": "ACANTHAT", "gene_reaction_rule": "b1463"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Adenosyl cobinamide phosphate guanyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ACBIPGT"]}, "metabolites": {"adocbip_c": -1.0, "ppi_c": 1.0, "gtp_c": -1.0, "h_c": -1.0, "agdpcbi_c": 1.0}, "id": "ACBIPGT", "gene_reaction_rule": "b1993"}, {"subsystem": "Membrane Lipid Metabolism", "name": "Acetyl-CoA carboxylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ACCOAC"]}, "metabolites": {"malcoa_c": 1.0, "adp_c": 1.0, "atp_c": -1.0, "hco3_c": -1.0, "h_c": 1.0, "accoa_c": -1.0, "pi_c": 1.0}, "id": "ACCOAC", "gene_reaction_rule": "b0185 and b2316 and b3255 and b3256"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Acetate-CoA ligase (ADP-forming)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ACCOAL"]}, "metabolites": {"adp_c": 1.0, "atp_c": -1.0, "ppa_c": -1.0, "coa_c": -1.0, "ppcoa_c": 1.0, "pi_c": 1.0}, "id": "ACCOAL", "gene_reaction_rule": "b4069"}, {"subsystem": "Alternate Carbon Metabolism", "name": "N-acetyl-D-galactosamine 1-phosphatase (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ACGAL1PPpp"]}, "metabolites": {"pi_p": 1.0, "h2o_p": -1.0, "acgal_p": 1.0, "acgal1p_p": -1.0}, "id": "ACGAL1PPpp", "gene_reaction_rule": ""}, {"subsystem": "Transport, Outer Membrane Porin", "name": "N-acetyl-D-galactosamine 1-phosphate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACGAL1Ptex"]}, "metabolites": {"acgal1p_p": 1.0, "acgal1p_e": -1.0}, "id": "ACGAL1Ptex", "gene_reaction_rule": "b0241 or b0929 or b1377 or b2215"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "N-acetyl-D-galactosamine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACGALtex"]}, "metabolites": {"acgal_p": 1.0, "acgal_e": -1.0}, "id": "ACGALtex", "gene_reaction_rule": "b0241 or b0929 or b1377 or b2215"}, {"subsystem": "Alternate Carbon Metabolism", "name": "N-acetyl-D-glucosamine 1-phosphatase (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ACGAM1PPpp"]}, "metabolites": {"pi_p": 1.0, "h2o_p": -1.0, "acgam_p": 1.0, "acgam1p_p": -1.0}, "id": "ACGAM1PPpp", "gene_reaction_rule": ""}, {"subsystem": "Transport, Outer Membrane Porin", "name": "N-acetyl-D-glucosamine 1-phosphate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": 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"notes": {"original_bigg_ids": ["ACGAptspp"]}, "metabolites": {"pep_c": -1.0, "pyr_c": 1.0, "acgam_p": -1.0, "acgam6p_c": 1.0}, "id": "ACGAptspp", "gene_reaction_rule": "(b2417 and b1101 and b2415 and b2416) or (b0679 and b2415 and b2416)"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "N-Acetyl-D-glucosamine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACGAtex"]}, "metabolites": {"acgam_p": 1.0, "acgam_e": -1.0}, "id": "ACGAtex", "gene_reaction_rule": "b0241 or b0929 or b1377 or b2215"}, {"subsystem": "Arginine and Proline Metabolism", "name": "Acetylglutamate kinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ACGK"]}, "metabolites": {"acg5p_c": 1.0, "acglu_c": -1.0, "adp_c": 1.0, "atp_c": -1.0}, "id": "ACGK", "gene_reaction_rule": "b3959"}, {"subsystem": "Arginine and Proline Metabolism", "name": "N-acetylglutamate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ACGS"]}, "metabolites": {"glu__L_c": -1.0, "acglu_c": 1.0, "coa_c": 1.0, "h_c": 1.0, "accoa_c": -1.0}, "id": "ACGS", "gene_reaction_rule": "b2818"}, {"subsystem": "Valine, Leucine, and Isoleucine Metabolism", "name": "2-aceto-2-hydroxybutanoate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ACHBS"]}, "metabolites": {"2ahbut_c": 1.0, "2obut_c": -1.0, "pyr_c": -1.0, "co2_c": 1.0, "h_c": -1.0}, "id": "ACHBS", "gene_reaction_rule": "(b3670 and b3671) or (b0077 and b0078)"}, {"subsystem": "Pyruvate Metabolism", "name": "Acetate kinase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACKr"]}, "metabolites": {"ac_c": -1.0, "actp_c": 1.0, "adp_c": 1.0, "atp_c": -1.0}, "id": "ACKr", "gene_reaction_rule": "b3115 or b2296 or b1849"}, {"subsystem": "Valine, Leucine, and Isoleucine Metabolism", "name": "Acetolactate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, 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"gene_reaction_rule": "b0433"}, {"subsystem": "Murein Recycling", "name": "N-Acetyl-D-glucosamine(anhydrous)N-Acetylmuramyl-tetrapeptide amidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AGM4PA"]}, "metabolites": {"h2o_c": -1.0, "anhgm4p_c": -1.0, "LalaDgluMdapDala_c": 1.0, "anhgm_c": 1.0}, "id": "AGM4PA", "gene_reaction_rule": "b0110"}, {"subsystem": "Murein Recycling", "name": "N-Acetyl-D-glucosamine(anhydrous)N-Acetylmuramyl-tetrapeptide amidase (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AGM4PApp"]}, "metabolites": {"h2o_p": -1.0, "anhgm4p_p": -1.0, "anhgm_p": 1.0, "LalaDgluMdapDala_p": 1.0}, "id": "AGM4PApp", "gene_reaction_rule": "b2435 or b2817 or b4169"}, {"subsystem": "Murein Recycling", "name": "N-Acetyl-D-glucosamine(anhydrous)N-Acetylmuramyl-tetrapeptide L,D-carboxypeptidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AGM4PCP"]}, "metabolites": {"anhgm4p_c": -1.0, "h2o_c": -1.0, "ala__D_c": 1.0, "anhgm3p_c": 1.0}, "id": "AGM4PCP", "gene_reaction_rule": "b1192"}, {"subsystem": "Murein Recycling", "name": "N-Acetyl-D-glucosamine(anhydrous)N-Acetylmuramyl-tetrapeptide L,D-carboxypeptidase (periplasmic)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AGM4PCPpp"]}, "metabolites": {"h2o_p": -1.0, "ala__D_p": 1.0, "anhgm3p_p": 1.0, "anhgm4p_p": -1.0}, "id": "AGM4PCPpp", "gene_reaction_rule": ""}, {"subsystem": "Murein Recycling", "name": "N-Acetyl-D-glucosamine(anhydrous)N-Acetylmuramyl-tetrapeptide beta -1,4-N-acetylglucosaminidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AGM4PH"]}, "metabolites": {"acgam_c": 1.0, "anhm4p_c": 1.0, "anhgm4p_c": -1.0, "h2o_c": -1.0}, "id": "AGM4PH", "gene_reaction_rule": "b1107"}, {"subsystem": "Murein Recycling", "name": "GlcNAc-anhMurNAc tetrapeptide transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AGM4Pt2pp"]}, "metabolites": {"anhgm4p_c": 1.0, "h_c": 1.0, "h_p": -1.0, "anhgm4p_p": -1.0}, "id": "AGM4Pt2pp", "gene_reaction_rule": "b0433"}, {"subsystem": "Murein Recycling", "name": "N-Acetyl-D-glucosamine(anhydrous)N-Acetylmuramyl beta -1,4-N-acetylglucosaminidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AGMH"]}, "metabolites": {"anhm_c": 1.0, "acgam_c": 1.0, "h2o_c": -1.0, "anhgm_c": -1.0}, "id": "AGMH", "gene_reaction_rule": "b1107"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "ADP-D-glycero-D-manno-heptose epimerase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AGMHE"]}, "metabolites": {"adphep_LD_c": 1.0, "adphep_DD_c": -1.0}, "id": "AGMHE", "gene_reaction_rule": "b3619"}, {"subsystem": "Arginine and Proline Metabolism", "name": "Agmatinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AGMT"]}, "metabolites": {"ptrc_c": 1.0, "agm_c": -1.0, "urea_c": 1.0, "h2o_c": -1.0}, "id": "AGMT", "gene_reaction_rule": "b2937"}, {"subsystem": "Murein Recycling", "name": "GlcNAc-anhMurNAc transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AGMt2pp"]}, "metabolites": {"h_p": -1.0, "anhgm_p": -1.0, "anhgm_c": 1.0, "h_c": 1.0}, "id": "AGMt2pp", "gene_reaction_rule": "b0433"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Agmatine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["AGMtex"]}, "metabolites": {"agm_p": 1.0, "agm_e": -1.0}, "id": "AGMtex", "gene_reaction_rule": "b0241 or b0929 or b1377 or b2215"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "1-tetradecanoyl-sn-glycerol 3-phosphate O-acyltransferase (n-C12:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AGPAT120"]}, "metabolites": {"1ddecg3p_c": -1.0, "ACP_c": 1.0, "pa120_c": 1.0, "ddcaACP_c": -1.0}, "id": "AGPAT120", "gene_reaction_rule": "b3018"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "1-tetradecanoyl-sn-glycerol 3-phosphate O-acyltransferase (n-C14:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AGPAT140"]}, "metabolites": {"1tdecg3p_c": -1.0, "pa140_c": 1.0, "ACP_c": 1.0, "myrsACP_c": -1.0}, "id": "AGPAT140", "gene_reaction_rule": "b3018"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "1-tetradec-7-enoyl-sn-glycerol 3-phosphate O-acyltransferase (n-C14:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AGPAT141"]}, "metabolites": {"tdeACP_c": -1.0, "pa141_c": 1.0, "ACP_c": 1.0, "1tdec7eg3p_c": -1.0}, "id": "AGPAT141", "gene_reaction_rule": "b3018"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "1-hexadecanoyl-sn-glycerol 3-phosphate O-acyltransferase (n-C16:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AGPAT160"]}, "metabolites": {"pa160_c": 1.0, "ACP_c": 1.0, "1hdecg3p_c": -1.0, "palmACP_c": -1.0}, "id": "AGPAT160", "gene_reaction_rule": "b3018"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "1-hexadec-7-enoyl-sn-glycerol 3-phosphate O-acyltransferase (n-C16:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AGPAT161"]}, "metabolites": {"pa161_c": 1.0, "1hdec9eg3p_c": -1.0, "ACP_c": 1.0, "hdeACP_c": -1.0}, "id": "AGPAT161", "gene_reaction_rule": "b3018"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "1-octadecanoyl-sn-glycerol 3-phosphate O-acyltransferase (n-C18:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AGPAT180"]}, "metabolites": {"ocdcaACP_c": -1.0, "ACP_c": 1.0, "1odecg3p_c": -1.0, "pa180_c": 1.0}, "id": "AGPAT180", "gene_reaction_rule": "b3018"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "1-octadec-7-enoyl-sn-glycerol 3-phosphate O-acyltransferase (n-C18:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AGPAT181"]}, "metabolites": {"1odec11eg3p_c": -1.0, "octeACP_c": -1.0, "ACP_c": 1.0, "pa181_c": 1.0}, "id": "AGPAT181", "gene_reaction_rule": "b3018"}, {"subsystem": "Arginine and Proline Metabolism", "name": "N-acetyl-g-glutamyl-phosphate reductase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["AGPR"]}, "metabolites": {"nadp_c": -1.0, "nadph_c": 1.0, "acg5p_c": 1.0, "acg5sa_c": -1.0, "h_c": 1.0, "pi_c": -1.0}, "id": "AGPR", "gene_reaction_rule": "b3958"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Silver transport out via proton antiport", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AGt3"]}, "metabolites": {"ag_e": 1.0, "h_e": -1.0, "h_c": 1.0, "ag_c": -1.0}, "id": "AGt3", "gene_reaction_rule": "b0572 and b0573 and b0574 and b0575"}, {"subsystem": "Methionine Metabolism", "name": "S-adenosylhomocysteine nucleosidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AHCYSNS"]}, "metabolites": {"ahcys_c": -1.0, "h2o_c": -1.0, "ade_c": 1.0, "rhcys_c": 1.0}, "id": "AHCYSNS", "gene_reaction_rule": "b0159"}, {"subsystem": "Purine and Pyrimidine Biosynthesis", "name": "Phosphoribosylaminoimidazolecarboxamide formyltransferase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["AICART"]}, "metabolites": {"aicar_c": -1.0, "fprica_c": 1.0, "10fthf_c": -1.0, "thf_c": 1.0}, "id": "AICART", "gene_reaction_rule": "b4006"}, {"subsystem": "Purine and Pyrimidine Biosynthesis", "name": "Phosphoribosylaminoimidazole carboxylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AIRC2"]}, "metabolites": {"5caiz_c": 1.0, "atp_c": -1.0, "hco3_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "air_c": -1.0, "pi_c": 1.0}, "id": "AIRC2", "gene_reaction_rule": "b0522"}, {"subsystem": "Purine and Pyrimidine Biosynthesis", "name": "Phosphoribosylaminoimidazole carboxylase (mutase rxn)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["AIRC3"]}, "metabolites": {"5caiz_c": 1.0, "5aizc_c": -1.0}, "id": "AIRC3", "gene_reaction_rule": "b0523"}, {"subsystem": "Citric Acid Cycle", "name": "2-Oxogluterate dehydrogenase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AKGDH"]}, "metabolites": {"akg_c": -1.0, "nadh_c": 1.0, "succoa_c": 1.0, "coa_c": -1.0, "nad_c": -1.0, "co2_c": 1.0}, "id": "AKGDH", "gene_reaction_rule": "b0116 and b0726 and b0727"}, {"subsystem": "Transport, Inner Membrane", "name": "2-oxoglutarate reversible transport via symport (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["AKGt2rpp"]}, "metabolites": {"akg_c": 1.0, "akg_p": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "AKGt2rpp", "gene_reaction_rule": "b2587"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Alpha-ketoglutarate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["AKGtex"]}, "metabolites": {"akg_p": 1.0, "akg_e": -1.0}, "id": "AKGtex", "gene_reaction_rule": "b0241 or b0929 or b1377 or b2215"}, {"subsystem": "Murein Recycling", "name": "D-alanine-D-alanine dipeptidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALAALAD"]}, "metabolites": {"h2o_c": -1.0, "ala__D_c": 2.0, "alaala_c": -1.0}, "id": "ALAALAD", "gene_reaction_rule": "b1488"}, {"subsystem": "Transport, Inner Membrane", "name": "D-alanyl-D-alanine (DalaDala) transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALAALAabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "alaala_p": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "alaala_c": 1.0}, "id": "ALAALAabcpp", "gene_reaction_rule": "(b1487 and b1486 and b1485 and b1484 and b1483) or (b3544 and b3543 and b3542 and b3541 and b3540)"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "D-alanine-D-alanine ligase (reversible)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ALAALAr"]}, "metabolites": {"atp_c": -1.0, "ala__D_c": -2.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "alaala_c": 1.0}, "id": "ALAALAr", "gene_reaction_rule": "b0381 or b0092"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "D-alanyl-D-alanine (DalaDala) transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ALAALAtex"]}, "metabolites": {"alaala_e": -1.0, "alaala_p": 1.0}, "id": "ALAALAtex", "gene_reaction_rule": "b0241 or b0929 or b1377 or b2215"}, {"subsystem": "Murein Recycling", "name": "L-alanyl-gamma-glutamate epimerase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ALAGLUE"]}, "metabolites": {"LalaLglu_c": 1.0, "LalaDglu_c": -1.0}, "id": "ALAGLUE", "gene_reaction_rule": "b1325"}, {"subsystem": "Alanine and Aspartate Metabolism", "name": "Alanine racemase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ALAR"]}, "metabolites": {"ala__D_c": 1.0, "ala__L_c": -1.0}, "id": "ALAR", "gene_reaction_rule": "b1190 or b4053"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "D-alanine transaminase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALATA_D2"]}, "metabolites": {"ala__D_c": -1.0, "pyr_c": 1.0, "pydx5p_c": -1.0, "pyam5p_c": 1.0}, "id": "ALATA_D2", "gene_reaction_rule": "b2551 or b0870"}, {"subsystem": "Alanine and Aspartate Metabolism", "name": "L-alanine transaminase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ALATA_L"]}, "metabolites": {"akg_c": -1.0, "pyr_c": 1.0, "ala__L_c": -1.0, "glu__L_c": 1.0}, "id": "ALATA_L", "gene_reaction_rule": "b2290 or b2379"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Alanine transaminase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALATA_L2"]}, "metabolites": {"pydx5p_c": -1.0, "pyam5p_c": 1.0, "ala__L_c": -1.0, "pyr_c": 1.0}, "id": "ALATA_L2", "gene_reaction_rule": "b0870 or b2551"}, {"subsystem": "tRNA Charging", "name": "Alanyl-tRNA synthetase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALATRS"]}, "metabolites": {"trnaala_c": -1.0, "atp_c": -1.0, "ppi_c": 1.0, "ala__L_c": -1.0, "amp_c": 1.0, "alatrna_c": 1.0}, "id": "ALATRS", "gene_reaction_rule": "b2697"}, {"subsystem": "Transport, Inner Membrane", "name": "L-alanine transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALAabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "ala__L_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "ala__L_p": -1.0}, "id": "ALAabcpp", "gene_reaction_rule": "b3454 and b3455 and b3457 and b3460 and b3456"}, {"subsystem": "Transport, Inner Membrane", "name": "L-alanine transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALAt2pp", "ALAt2rpp"]}, "metabolites": {"ala__L_c": 1.0, "h_c": 1.0, "h_p": -1.0, "ala__L_p": -1.0}, "id": "ALAt2pp_copy1", "gene_reaction_rule": "b4208"}, {"subsystem": "Transport, Inner Membrane", "name": "L-alanine transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ALAt2pp", "ALAt2rpp"]}, "metabolites": {"ala__L_c": 1.0, "h_c": 1.0, "h_p": -1.0, "ala__L_p": -1.0}, "id": "ALAt2pp_copy2", "gene_reaction_rule": ""}, {"subsystem": "Transport, Inner Membrane", "name": "L-alanine transport in via sodium symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALAt4pp"]}, "metabolites": {"na1_p": -1.0, "na1_c": 1.0, "ala__L_c": 1.0, "ala__L_p": -1.0}, "id": "ALAt4pp", "gene_reaction_rule": "b0007"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "L-alanine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ALAtex"]}, "metabolites": {"ala__L_e": -1.0, "ala__L_p": 1.0}, "id": "ALAtex", "gene_reaction_rule": "b0241 or b0929 or b1377 or b2215"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Alcohol dehydrogenase (glycerol)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ALCD19"]}, "metabolites": {"glyald_c": -1.0, "nadh_c": -1.0, "h_c": -1.0, "nad_c": 1.0, "glyc_c": 1.0}, "id": "ALCD19", "gene_reaction_rule": "b0356"}, {"subsystem": "Pyruvate Metabolism", "name": "Alcohol dehydrogenase (ethanol)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ALCD2x"]}, "metabolites": {"acald_c": 1.0, "nadh_c": 1.0, "nad_c": -1.0, "etoh_c": -1.0, "h_c": 1.0}, "id": "ALCD2x", "gene_reaction_rule": "b1478 or b1241 or b0356"}, {"subsystem": "Alternate 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{"subsystem": "Glycerophospholipid Metabolism", "name": "Acylphosphatase (C16:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["APH160"]}, "metabolites": {"h2o_c": -1.0, "pi_c": 1.0, "hdca_c": 1.0, "hdcap_c": -1.0, "h_c": 2.0}, "id": "APH160", "gene_reaction_rule": "b0968"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Acylphosphatase (C16:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["APH161"]}, "metabolites": {"hdcea_c": 1.0, "hdceap_c": -1.0, "h2o_c": -1.0, "pi_c": 1.0, "h_c": 2.0}, "id": "APH161", "gene_reaction_rule": "b0968"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Acylphosphatase (C18:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["APH180"]}, "metabolites": {"h2o_c": -1.0, "pi_c": 1.0, "ocdcap_c": -1.0, "h_c": 2.0, "ocdca_c": 1.0}, "id": "APH180", "gene_reaction_rule": "b0968"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Acylphosphatase (C18:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["APH181"]}, "metabolites": {"ocdcea_c": 1.0, "h2o_c": -1.0, "pi_c": 1.0, "h_c": 2.0, "ocdceap_c": -1.0}, "id": "APH181", "gene_reaction_rule": "b0968"}, {"subsystem": "Threonine and Lysine Metabolism", "name": "Aminopropanol dehydrogenase reversible", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["APPLDHr"]}, "metabolites": {"appl_c": 1.0, "nadh_c": -1.0, "h_c": -1.0, "nad_c": 1.0, "aact_c": -1.0}, "id": "APPLDHr", "gene_reaction_rule": "b3945"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "5-amino-6-(5-phosphoribosylamino)uracil reductase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["APRAUR"]}, "metabolites": {"5apru_c": -1.0, "nadp_c": 1.0, "nadph_c": -1.0, "5aprbu_c": 1.0, "h_c": -1.0}, "id": "APRAUR", "gene_reaction_rule": "b0414"}, {"subsystem": "Alternate Carbon Metabolism", "name": "L-arabinose isomerase", 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"name": "L-arginine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ARGtex"]}, "metabolites": {"arg__L_e": -1.0, "arg__L_p": 1.0}, "id": "ARGtex", "gene_reaction_rule": "b0241 or b0929 or b1377 or b2215"}, {"subsystem": "Threonine and Lysine Metabolism", "name": "Aspartate-semialdehyde dehydrogenase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ASAD"]}, "metabolites": {"aspsa_c": -1.0, "nadp_c": -1.0, "nadph_c": 1.0, "h_c": 1.0, "pi_c": -1.0, "4pasp_c": 1.0}, "id": "ASAD", "gene_reaction_rule": "b3433"}, {"subsystem": "Alternate Carbon Metabolism", "name": "L-ascorbate 6-phosphate lactonase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ASCBPL"]}, "metabolites": {"3dhgulnp_c": 1.0, "ascb6p_c": -1.0, "h_c": 1.0, "h2o_c": -1.0}, "id": "ASCBPL", "gene_reaction_rule": "b4192"}, {"subsystem": "Transport, Inner Membrane", "name": "L-ascorbate transport via PEP:Pyr PTS (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ASCBptspp"]}, "metabolites": {"pep_c": -1.0, "pyr_c": 1.0, "ascb__L_p": -1.0, "ascb6p_c": 1.0}, "id": "ASCBptspp", "gene_reaction_rule": "b2415 and b2416 and b4195 and b4194 and b4193"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "L-ascorbate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ASCBtex"]}, "metabolites": {"ascb__L_p": 1.0, "ascb__L_e": -1.0}, "id": "ASCBtex", "gene_reaction_rule": "b0241 or b0929 or b1377 or b2215"}, {"subsystem": "Alanine and Aspartate Metabolism", "name": "L-asparaginase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ASNN"]}, "metabolites": {"asp__L_c": 1.0, "h2o_c": -1.0, "asn__L_c": -1.0, "nh4_c": 1.0}, "id": "ASNN", "gene_reaction_rule": "b1767 or b0828"}, {"subsystem": "Alanine and Aspartate 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{"subsystem": "Glycerophospholipid Metabolism", "name": "CDP-Diacylglycerol pyrophostatase (n-C14:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CDAPPA141"]}, "metabolites": {"pa141_c": 1.0, "cmp_c": 1.0, "h_c": 2.0, "h2o_c": -1.0, "cdpdtdec7eg_c": -1.0}, "id": "CDAPPA141", "gene_reaction_rule": "b3918"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "CDP-Diacylglycerol pyrophostatase (n-C16:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CDAPPA160"]}, "metabolites": {"pa160_c": 1.0, "h2o_c": -1.0, "cmp_c": 1.0, "h_c": 2.0, "cdpdhdecg_c": -1.0}, "id": "CDAPPA160", "gene_reaction_rule": "b3918"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "CDP-Diacylglycerol pyrophostatase (n-C16:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CDAPPA161"]}, "metabolites": {"pa161_c": 1.0, "h2o_c": -1.0, "cdpdhdec9eg_c": -1.0, "h_c": 2.0, "cmp_c": 1.0}, "id": "CDAPPA161", "gene_reaction_rule": "b3918"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "CDP-Diacylglycerol pyrophostatase (n-C18:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CDAPPA180"]}, "metabolites": {"h_c": 2.0, "h2o_c": -1.0, "cmp_c": 1.0, "cdpdodecg_c": -1.0, "pa180_c": 1.0}, "id": "CDAPPA180", "gene_reaction_rule": "b3918"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "CDP-Diacylglycerol pyrophostatase (n-C18:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CDAPPA181"]}, "metabolites": {"pa181_c": 1.0, "h2o_c": -1.0, "h_c": 2.0, "cdpdodec11eg_c": -1.0, "cmp_c": 1.0}, "id": "CDAPPA181", "gene_reaction_rule": "b3918"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "7-cyano-7-deazaguanine reductase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CDGR"]}, "metabolites": {"preq1_c": 1.0, "preq0_c": -1.0, "nadp_c": 2.0, "nadph_c": -2.0, "h_c": -3.0}, 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"name": "Choline dehydrogenase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CHOLD"]}, "metabolites": {"chol_c": -1.0, "nadh_c": 1.0, "betald_c": 1.0, "h_c": 1.0, "nad_c": -1.0}, "id": "CHOLD", "gene_reaction_rule": "b0311"}, {"subsystem": "Tyrosine, Tryptophan, and Phenylalanine Metabolism", "name": "Chorismate mutase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CHORM"]}, "metabolites": {"pphn_c": 1.0, "chor_c": -1.0}, "id": "CHORM", "gene_reaction_rule": "b2599 or b2600"}, {"subsystem": "Tyrosine, Tryptophan, and Phenylalanine Metabolism", "name": "Chorismate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CHORS"]}, "metabolites": {"chor_c": 1.0, "pi_c": 1.0, "3psme_c": -1.0}, "id": "CHORS", "gene_reaction_rule": "b2329"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Chorismate pyruvate lyase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": 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"succ_c": -1.0, "cit_p": -1.0, "cit_c": 1.0}, "id": "CITt7pp", "gene_reaction_rule": "b0612"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Citrate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["CITtex"]}, "metabolites": {"cit_e": -1.0, "cit_p": 1.0}, "id": "CITtex", "gene_reaction_rule": "b0241 or b0929 or b1377 or b2215"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "Cold lipid A transport via ABC system (periplasm to extracellular)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CLIPAabctex"]}, "metabolites": {"lipa_cold_e": 1.0, "atp_c": -1.0, "h2o_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "lipa_cold_p": -1.0, "pi_c": 1.0}, "id": "CLIPAabctex", "gene_reaction_rule": "b3200 and b3201 and b3199 and b4261 and b4262"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Cardiolipin hydrolase (periplasm, n-C12:0)", "upper_bound": 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{"subsystem": "Oxidative Phosphorylation", "name": "Carnitine-CoA racemase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["CRNCAR"]}, "metabolites": {"crnDcoa_c": 1.0, "crncoa_c": -1.0}, "id": "CRNCAR", "gene_reaction_rule": "b0036"}, {"subsystem": "Oxidative Phosphorylation", "name": "Crotonobetainyl-CoA: carnitine CoA transferase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["CRNCBCT"]}, "metabolites": {"crn_c": -1.0, "ctbtcoa_c": -1.0, "crncoa_c": 1.0, "ctbt_c": 1.0}, "id": "CRNCBCT", "gene_reaction_rule": "b0038"}, {"subsystem": "Oxidative Phosphorylation", "name": "Carnityl-CoA dehydratse", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["CRNCDH"]}, "metabolites": {"ctbtcoa_c": 1.0, "h2o_c": 1.0, "crncoa_c": -1.0}, "id": "CRNCDH", "gene_reaction_rule": "b0036"}, {"subsystem": "Oxidative Phosphorylation", "name": "D-Carnitine-CoA Ligase", "upper_bound": 1000.0, "lower_bound": 0.0, 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Phosphorylation", "name": "Cytochrome oxidase bd (ubiquinol-8: 2 protons) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CYTBDpp"]}, "metabolites": {"o2_c": -0.5, "h2o_c": 1.0, "h_p": 2.0, "q8h2_c": -1.0, "h_c": -2.0, "q8_c": 1.0}, "id": "CYTBDpp", "gene_reaction_rule": "(b0978 and b0979) or (b0733 and b0734)"}, {"subsystem": "Oxidative Phosphorylation", "name": "Cytochrome oxidase bo3 (ubiquinol-8: 4 protons) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CYTBO3_4pp"]}, "metabolites": {"o2_c": -0.5, "h2o_c": 1.0, "h_p": 4.0, "q8h2_c": -1.0, "h_c": -4.0, "q8_c": 1.0}, "id": "CYTBO3_4pp", "gene_reaction_rule": "b0429 and b0430 and b0431 and b0432"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Cytidine deaminase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CYTD"]}, "metabolites": {"cytd_c": -1.0, "uri_c": 1.0, "h2o_c": -1.0, "nh4_c": 1.0, "h_c": -1.0}, "id": 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"Cofactor and Prosthetic Group Biosynthesis", "name": "Dihydrofolate reductase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DHFR"]}, "metabolites": {"dhf_c": -1.0, "nadp_c": 1.0, "nadph_c": -1.0, "h_c": -1.0, "thf_c": 1.0}, "id": "DHFR", "gene_reaction_rule": "b1606 or b0048"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Dihydrofolate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHFS"]}, "metabolites": {"dhf_c": 1.0, "atp_c": -1.0, "glu__L_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "dhpt_c": -1.0, "pi_c": 1.0}, "id": "DHFS", "gene_reaction_rule": "b2315"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Dihydromonapterin reductase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHMPTR"]}, "metabolites": {"nadph_c": -1.0, "thmnp_c": 1.0, "nadp_c": 1.0, "dhmpt_c": -1.0, "h_c": -1.0}, "id": "DHMPTR", "gene_reaction_rule": "b1606"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "1,4-dihydroxy-2-naphthoate octaprenyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHNAOT4"]}, "metabolites": {"dhna_c": -1.0, "octdp_c": -1.0, "ppi_c": 1.0, "2dmmql8_c": 1.0, "h_c": -1.0, "co2_c": 1.0}, "id": "DHNAOT4", "gene_reaction_rule": "b3930"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "1,4-dihydroxy-2-napthoyl-CoA synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHNCOAS"]}, "metabolites": {"sbzcoa_c": -1.0, "h2o_c": 1.0, "h_c": -1.0, "14dhncoa_c": 1.0}, "id": "DHNCOAS", "gene_reaction_rule": "b2262"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "1,4-dihydroxy-2-napthoyl-CoA thioesterase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHNCOAT"]}, "metabolites": {"h2o_c": -1.0, "dhna_c": 1.0, "coa_c": 1.0, "h_c": 1.0, "14dhncoa_c": -1.0}, "id": "DHNCOAT", "gene_reaction_rule": "b0736"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Dihydroneopterin aldolase reversible", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DHNPA2r"]}, "metabolites": {"dhnpt_c": -1.0, "6hmhpt_c": 1.0, "gcald_c": 1.0}, "id": "DHNPA2r", "gene_reaction_rule": "b3058"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Dihydroneopterin epimerase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DHNPTE"]}, "metabolites": {"dhnpt_c": -1.0, "dhmpt_c": 1.0}, "id": "DHNPTE", "gene_reaction_rule": "b3058"}, {"subsystem": "Purine and Pyrimidine Biosynthesis", "name": "Dihydoorotic acid dehydrogenase (quinone8)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHORD2"]}, "metabolites": {"q8h2_c": 1.0, "dhor__S_c": -1.0, "q8_c": -1.0, "orot_c": 1.0}, "id": "DHORD2", "gene_reaction_rule": "b0945"}, {"subsystem": "Purine and Pyrimidine Biosynthesis", "name": "Dihydroorotic acid (menaquinone-8)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHORD5"]}, "metabolites": {"dhor__S_c": -1.0, "mqn8_c": -1.0, "mql8_c": 1.0, "orot_c": 1.0}, "id": "DHORD5", "gene_reaction_rule": "b0945"}, {"subsystem": "Purine and Pyrimidine Biosynthesis", "name": "Fumarate dependent DHORD", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHORDfum"]}, "metabolites": {"fum_c": -1.0, "succ_c": 1.0, "dhor__S_c": -1.0, "orot_c": 1.0}, "id": "DHORDfum", "gene_reaction_rule": ""}, {"subsystem": "Purine and Pyrimidine Biosynthesis", "name": "Dihydroorotase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DHORTS"]}, "metabolites": {"cbasp_c": 1.0, "h2o_c": -1.0, "dhor__S_c": -1.0, "h_c": 1.0}, "id": "DHORTS", "gene_reaction_rule": "b1062"}, {"subsystem": "Alternate Carbon Metabolism", "name": "2,3-dihydroxyphenylpropionate dehydrogenase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHPPD"]}, "metabolites": {"cechddd_c": -1.0, "dhpppn_c": 1.0, "nadh_c": 1.0, "h_c": 1.0, "nad_c": -1.0}, "id": "DHPPD", "gene_reaction_rule": "b2541"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Diaminohydroxyphosphoribosylaminopryrimidine deaminase (25drapp)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHPPDA2"]}, "metabolites": {"h_c": -1.0, "5apru_c": 1.0, "h2o_c": -1.0, "nh4_c": 1.0, "25drapp_c": -1.0}, "id": "DHPPDA2", "gene_reaction_rule": "b0414"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Dihydropteroate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHPS2"]}, "metabolites": {"dhpt_c": 1.0, "6hmhptpp_c": -1.0, "ppi_c": 1.0, "4abz_c": -1.0}, "id": "DHPS2", "gene_reaction_rule": "b3177"}, {"subsystem": "Methionine Metabolism", "name": "4,5-dihydroxy-2,3-pentanedione cyclization (spontaneous)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHPTDCs2"]}, "metabolites": {"dhptd_c": -1.0, "mdhdhf_c": 1.0}, "id": "DHPTDCs2", "gene_reaction_rule": "s0001"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Dihydropteridine reductase", "upper_bound": 0.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHPTDNR"]}, "metabolites": {"thptdn_c": 1.0, "dhptdn_c": -1.0, "nadp_c": 1.0, "nadph_c": -1.0, "h_c": -3.0}, "id": "DHPTDNR", "gene_reaction_rule": "b0578"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Dihydropteridine reductase (NADH)", "upper_bound": 0.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHPTDNRN"]}, "metabolites": {"thptdn_c": 1.0, "dhptdn_c": -1.0, "nadh_c": -1.0, "h_c": -3.0, "nad_c": 1.0}, "id": "DHPTDNRN", "gene_reaction_rule": "b0578"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Dihydroneopterin triphosphate 2'-epimerase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DHPTPE"]}, "metabolites": {"dhmptp_c": 1.0, "ahdt_c": -1.0}, "id": "DHPTPE", "gene_reaction_rule": "b2303"}, {"subsystem": "Tyrosine, Tryptophan, and Phenylalanine Metabolism", "name": "3-dehydroquinate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHQS"]}, "metabolites": {"3dhq_c": 1.0, "pi_c": 1.0, "2dda7p_c": -1.0}, "id": "DHQS", "gene_reaction_rule": "b3389"}, {"subsystem": "Tyrosine, Tryptophan, and Phenylalanine Metabolism", "name": "3-dehydroquinate dehydratase, irreversible", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHQTi"]}, "metabolites": {"3dhsk_c": 1.0, "h2o_c": 1.0, "3dhq_c": -1.0}, "id": "DHQTi", "gene_reaction_rule": "b1693"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "DIMP transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DIMPtex"]}, "metabolites": {"dimp_p": 1.0, "dimp_e": -1.0}, "id": "DIMPtex", "gene_reaction_rule": "b0241 or b0929 or b1377 or b2215"}, {"subsystem": "Transport, Inner Membrane", "name": "Deoxyinosine transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DINSt2pp"]}, "metabolites": {"din_p": -1.0, "din_c": 1.0, "h_c": 1.0, "h_p": -1.0}, "id": "DINSt2pp", "gene_reaction_rule": "b2964"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Deoxyinosine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DINStex"]}, "metabolites": {"din_p": 1.0, "din_e": -1.0}, "id": "DINStex", "gene_reaction_rule": "b0241 or b0929 or b1377 or b2215"}, {"subsystem": "Alternate Carbon Metabolism", "name": "2,5-diketo-D-gluconate reductase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DKGLCNR1"]}, "metabolites": {"25dkglcn_c": -1.0, "nadp_c": 1.0, "nadph_c": -1.0, "h_c": -1.0, "2dhguln_c": 1.0}, "id": "DKGLCNR1", "gene_reaction_rule": "b0207 or b3012"}, {"subsystem": "Alternate Carbon Metabolism", "name": "2,5-diketo-D-gluconate reductase (NADH)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DKGLCNR2x"]}, "metabolites": {"25dkglcn_c": -1.0, "5dglcn_c": 1.0, "nadh_c": -1.0, "h_c": -1.0, "nad_c": 1.0}, "id": "DKGLCNR2x", "gene_reaction_rule": "b3553"}, {"subsystem": "Alternate Carbon Metabolism", "name": "2,5-diketo-D-gluconate reductase (NADPH)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DKGLCNR2y"]}, "metabolites": {"25dkglcn_c": -1.0, "nadp_c": 1.0, "nadph_c": -1.0, "5dglcn_c": 1.0, "h_c": -1.0}, "id": "DKGLCNR2y", "gene_reaction_rule": "b3553"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Dimethylallyltranstransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DMATT"]}, "metabolites": {"dmpp_c": -1.0, "ppi_c": 1.0, "ipdp_c": -1.0, "grdp_c": 1.0}, "id": "DMATT", "gene_reaction_rule": "b0421"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase (dmpp)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DMPPS"]}, "metabolites": {"h2o_c": 1.0, "dmpp_c": 1.0, "h2mb4p_c": -1.0, "h_c": -1.0, "nad_c": 1.0, "nadh_c": -1.0}, "id": "DMPPS", "gene_reaction_rule": "b0029"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "3-Dimethylubiquinonol 3-methyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DMQMT"]}, "metabolites": {"q8h2_c": 1.0, "2omhmbl_c": -1.0, "ahcys_c": 1.0, "h_c": 1.0, "amet_c": -1.0}, "id": "DMQMT", "gene_reaction_rule": "b2232"}, {"subsystem": "Oxidative Phosphorylation", "name": "Dimethyl sulfoxide reductase (Menaquinol 8)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DMSOR1"]}, 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(Demethylmenaquinol 8) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DMSOR2pp"]}, "metabolites": {"dms_p": 1.0, "h2o_p": 1.0, "dmso_p": -1.0, "2dmmq8_c": 1.0, "2dmmql8_c": -1.0}, "id": "DMSOR2pp", "gene_reaction_rule": "b1872 and b1873"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Dimethyl sulfoxide transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DMSOtex"]}, "metabolites": {"dmso_p": 1.0, "dmso_e": -1.0}, "id": "DMSOtex", "gene_reaction_rule": "b0241 or b0929 or b1377 or b2215"}, {"subsystem": "Transport, Inner Membrane", "name": "Dimethyl sulfoxide transport via diffusion (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DMSOtpp"]}, "metabolites": {"dmso_p": -1.0, "dmso_c": 1.0}, "id": "DMSOtpp", "gene_reaction_rule": "s0001"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Dimethyl 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{"subsystem": "Membrane Lipid Metabolism", "name": "3-hydroxyacyl-CoA dehydratase (3-hydroxydecanoyl-CoA)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ECOAH4"]}, "metabolites": {"3hdcoa_c": -1.0, "h2o_c": 1.0, "dc2coa_c": 1.0}, "id": "ECOAH4", "gene_reaction_rule": "b3846 or b2341"}, {"subsystem": "Membrane Lipid Metabolism", "name": "3-hydroxyacyl-CoA dehydratase (3-hydroxydodecanoyl-CoA)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ECOAH5"]}, "metabolites": {"h2o_c": 1.0, "3hddcoa_c": -1.0, "dd2coa_c": 1.0}, "id": "ECOAH5", "gene_reaction_rule": "b3846 or b2341"}, {"subsystem": "Membrane Lipid Metabolism", "name": "3-hydroxyacyl-CoA dehydratase (3-hydroxytetradecanoyl-CoA)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ECOAH6"]}, "metabolites": {"h2o_c": 1.0, "3htdcoa_c": -1.0, "td2coa_c": 1.0}, "id": "ECOAH6", "gene_reaction_rule": "b3846 or b2341"}, {"subsystem": "Membrane Lipid Metabolism", "name": "3-hydroxyacyl-CoA dehydratase (3-hydroxyhexadecanoyl-CoA)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ECOAH7"]}, "metabolites": {"h2o_c": 1.0, "hdd2coa_c": 1.0, "3hhdcoa_c": -1.0}, "id": "ECOAH7", "gene_reaction_rule": "b3846 or b2341"}, {"subsystem": "Membrane Lipid Metabolism", "name": "3-hydroxyacyl-CoA dehydratase (3-hydroxyoctadecanoyl-CoA)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ECOAH8"]}, "metabolites": {"3hodcoa_c": -1.0, "od2coa_c": 1.0, "h2o_c": 1.0}, "id": "ECOAH8", "gene_reaction_rule": "b3846 or b2341"}, {"subsystem": "Pentose Phosphate Pathway", "name": "2-dehydro-3-deoxy-phosphogluconate aldolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EDA"]}, "metabolites": {"pyr_c": 1.0, "g3p_c": 1.0, "2ddg6p_c": -1.0}, "id": "EDA", "gene_reaction_rule": "b1850"}, {"subsystem": "Pentose Phosphate Pathway", "name": "6-phosphogluconate 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Biosynthesis", "name": "Ethanolamine ammonia-lyase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ETHAAL"]}, "metabolites": {"acald_c": 1.0, "nh4_c": 1.0, "etha_c": -1.0}, "id": "ETHAAL", "gene_reaction_rule": "b2440 and b2441"}, {"subsystem": "Transport, Inner Membrane", "name": "Ethanolamine transport in via proton symport", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ETHAt2pp"]}, "metabolites": {"h_p": -1.0, "etha_p": -1.0, "etha_c": 1.0, "h_c": 1.0}, "id": "ETHAt2pp", "gene_reaction_rule": ""}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Ethanolamine transport via diffusion (extracellular)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ETHAtex"]}, "metabolites": {"etha_e": -1.0, "etha_p": 1.0}, "id": "ETHAtex", "gene_reaction_rule": "b0241 or b0929 or b1377 or b2215"}, {"subsystem": "Transport, Inner Membrane", "name": "Ethanesulfonate transport via ABC system 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{"subsystem": "Transport, Inner Membrane", "name": "Ethanol reversible transport via diffusion (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ETOHtrpp"]}, "metabolites": {"etoh_p": -1.0, "etoh_c": 1.0}, "id": "ETOHtrpp", "gene_reaction_rule": "s0001"}, {"subsystem": "Glycolysis/Gluconeogenesis", "name": "Fructose 6-phosphate aldolase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["F6PA"]}, "metabolites": {"g3p_c": 1.0, "dha_c": 1.0, "f6p_c": -1.0}, "id": "F6PA", "gene_reaction_rule": "b0825 or b3946"}, {"subsystem": "Alternate Carbon Metabolism", "name": "D-fructose 6-phosphate phosphatase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["F6PP"]}, "metabolites": {"h2o_c": -1.0, "pi_c": 1.0, "fru_c": 1.0, "f6p_c": -1.0}, "id": "F6PP", "gene_reaction_rule": "b0822"}, {"subsystem": "Transport, Inner Membrane", "name": "Fructose-6-phosphate transport via phosphate antiport 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{"subsystem": "Transport, Inner Membrane", "name": "Fumarate transport via proton symport (3 H) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["FUMt2_3pp"]}, "metabolites": {"fum_p": -1.0, "fum_c": 1.0, "h_c": 3.0, "h_p": -3.0}, "id": "FUMt2_3pp", "gene_reaction_rule": "b4138 or b4123 or b0621"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Fumarate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["FUMtex"]}, "metabolites": {"fum_p": 1.0, "fum_e": -1.0}, "id": "FUMtex", "gene_reaction_rule": "b0241 or b0929 or b1377 or b2215"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Fusidic acid transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["FUSAtex"]}, "metabolites": {"fusa_e": -1.0, "fusa_p": 1.0}, "id": "FUSAtex", "gene_reaction_rule": "b1377 or b2215 or 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{"subsystem": "Cell Envelope Biosynthesis", "name": "Glucose-1-phosphate thymidylyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["G1PTT"]}, "metabolites": {"dtdpglu_c": 1.0, "ppi_c": 1.0, "dttp_c": -1.0, "h_c": -1.0, "g1p_c": -1.0}, "id": "G1PTT", "gene_reaction_rule": "b2039 or b3789"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "D-glucose 1-phosphate transport via diffusion", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["G1Ptex"]}, "metabolites": {"g1p_e": -1.0, "g1p_p": 1.0}, "id": "G1Ptex", "gene_reaction_rule": "b0241 or b0929 or b1377 or b2215"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Glutamate-1-semialdehyde aminotransferase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["G1SAT"]}, "metabolites": {"5aop_c": 1.0, "glu1sa_c": -1.0}, "id": "G1SAT", "gene_reaction_rule": "b0154"}, {"subsystem": "Alternate Carbon Metabolism", 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"gene_reaction_rule": "b3126"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Glucarate dehydratase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLCRD"]}, "metabolites": {"h2o_c": 1.0, "5dh4dglc_c": 1.0, "glcr_c": -1.0}, "id": "GLCRD", "gene_reaction_rule": "b2788 or b2787"}, {"subsystem": "Transport, Inner Membrane", "name": "D-glucarate transport via proton symport, reversible (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GLCRt2rpp"]}, "metabolites": {"h_p": -1.0, "h_c": 1.0, "glcr_c": 1.0, "glcr_p": -1.0}, "id": "GLCRt2rpp", "gene_reaction_rule": "b3127 or b2789"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "D-glucarate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GLCRtex"]}, "metabolites": {"glcr_e": -1.0, "glcr_p": 1.0}, "id": "GLCRtex", "gene_reaction_rule": "b0241 or b0929 or b1377 or 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"b3627"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "Glucosyltransferase III (LPS core synthesis)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLCTR3"]}, "metabolites": {"ggagicolipa_c": -1.0, "udpg_c": -1.0, "udp_c": 1.0, "gggagicolipa_c": 1.0, "h_c": 1.0}, "id": "GLCTR3", "gene_reaction_rule": "b3626"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "D-glucuronate 1-phosphate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GLCUR1Ptex"]}, "metabolites": {"glcur1p_p": 1.0, "glcur1p_e": -1.0}, "id": "GLCUR1Ptex", "gene_reaction_rule": "b0241 or b0929 or b1377 or b2215"}, {"subsystem": "Transport, Inner Membrane", "name": "D-glucuronate transport via proton symport, reversible (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GLCURt2rpp"]}, "metabolites": {"glcur_c": 1.0, "h_c": 1.0, "h_p": -1.0, "glcur_p": -1.0}, "id": "GLCURt2rpp", "gene_reaction_rule": "b3909 or b3093"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "D-glucuronat transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GLCURtex"]}, "metabolites": {"glcur_e": -1.0, "glcur_p": 1.0}, "id": "GLCURtex", "gene_reaction_rule": "b0241 or b0929 or b1377 or b2215"}, {"subsystem": "Transport, Inner Membrane", "name": "D-glucose transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLCabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "glc__D_p": -1.0, "h_c": 1.0, "adp_c": 1.0, "glc__D_c": 1.0, "pi_c": 1.0}, "id": "GLCabcpp", "gene_reaction_rule": "b2149 and b2150 and b2148"}, {"subsystem": "Transport, Inner Membrane", "name": "D-glucose transport via PEP:Pyr PTS (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLCptspp"]}, "metabolites": {"pep_c": -1.0, "pyr_c": 1.0, "glc__D_p": -1.0, "g6p_c": 1.0}, "id": "GLCptspp", "gene_reaction_rule": "(b2417 and b1621 and b2415 and b2416) or (b2417 and b1101 and b2415 and b2416) or (b1817 and b1818 and b1819 and b2415 and b2416)"}, {"subsystem": "Transport, Inner Membrane", "name": "D-glucose transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLCt2pp"]}, "metabolites": {"glc__D_c": 1.0, "glc__D_p": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "GLCt2pp", "gene_reaction_rule": "b2943"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Glucose transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GLCtex", "GLCtexi"]}, "metabolites": {"glc__D_p": 1.0, "glc__D_e": -1.0}, "id": "GLCtex_copy1", "gene_reaction_rule": "b0241 or b0929 or b1377 or b2215"}, {"subsystem": "Transport, Outer Membrane", "name": "Glucose transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLCtex", "GLCtexi"]}, "metabolites": {"glc__D_p": 1.0, "glc__D_e": -1.0}, "id": "GLCtex_copy2", "gene_reaction_rule": "b4036"}, {"subsystem": "Glycolysis/Gluconeogenesis", "name": "Glycogen debranching enzyme (bglycogen -> glycogen)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLDBRAN2"]}, "metabolites": {"bglycogen_c": -1.0, "glycogen_c": 1.0}, "id": "GLDBRAN2", "gene_reaction_rule": "b3431"}, {"subsystem": "Glycolysis/Gluconeogenesis", "name": "Glucose-1-phosphate adenylyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLGC"]}, "metabolites": {"adpglc_c": 1.0, "ppi_c": 1.0, "h_c": -1.0, "atp_c": -1.0, "g1p_c": -1.0}, "id": "GLGC", "gene_reaction_rule": "b3430"}, {"subsystem": "Glutamate Metabolism", "name": "Glutamine synthetase", "upper_bound": 1000.0, "lower_bound": 0.0, 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1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GLUABUTt7pp"]}, "metabolites": {"glu__L_p": -1.0, "glu__L_c": 1.0, "4abut_p": 1.0, "4abut_c": -1.0}, "id": "GLUABUTt7pp", "gene_reaction_rule": "b1492"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Gamma-glutamylcysteine synthetase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLUCYS"]}, "metabolites": {"cys__L_c": -1.0, "pi_c": 1.0, "atp_c": -1.0, "glu__L_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "glucys_c": 1.0}, "id": "GLUCYS", "gene_reaction_rule": "b2688"}, {"subsystem": "Glutamate Metabolism", "name": "Glutamate Decarboxylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLUDC"]}, "metabolites": {"glu__L_c": -1.0, "co2_c": 1.0, "h_c": -1.0, "4abut_c": 1.0}, "id": "GLUDC", "gene_reaction_rule": "b3517 or b1493"}, {"subsystem": "Glutamate Metabolism", "name": "Glutamate dehydrogenase (NADP)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GLUDy"]}, "metabolites": {"akg_c": 1.0, "h2o_c": -1.0, "nadp_c": -1.0, "nadph_c": 1.0, "glu__L_c": -1.0, "h_c": 1.0, "nh4_c": 1.0}, "id": "GLUDy", "gene_reaction_rule": "b1761"}, {"subsystem": "Glutamate Metabolism", "name": "Glutaminase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLUN"]}, "metabolites": {"glu__L_c": 1.0, "gln__L_c": -1.0, "h2o_c": -1.0, "nh4_c": 1.0}, "id": "GLUN", "gene_reaction_rule": "b1812 or b0485 or b1524"}, {"subsystem": "Glutamate Metabolism", "name": "Glutaminase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLUNpp"]}, "metabolites": {"glu__L_p": 1.0, "gln__L_p": -1.0, "nh4_p": 1.0, "h2o_p": -1.0}, "id": "GLUNpp", "gene_reaction_rule": "b2957"}, {"subsystem": "Purine and Pyrimidine Biosynthesis", "name": "Glutamine phosphoribosyldiphosphate amidotransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLUPRT"]}, 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{"subsystem": "Glyoxylate Metabolism", "name": "Glycolate dehydrogenase (NAD)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLYCLTDx"]}, "metabolites": {"glyclt_c": 1.0, "nadh_c": -1.0, "glx_c": -1.0, "h_c": -1.0, "nad_c": 1.0}, "id": "GLYCLTDx", "gene_reaction_rule": "b3553 or b1033"}, {"subsystem": "Glyoxylate Metabolism", "name": "Glycolate dehydrogenase (NADP)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLYCLTDy"]}, "metabolites": {"glyclt_c": 1.0, "nadp_c": 1.0, "nadph_c": -1.0, "glx_c": -1.0, "h_c": -1.0}, "id": "GLYCLTDy", "gene_reaction_rule": "b1033 or b3553"}, {"subsystem": "Transport, Inner Membrane", "name": "Glycolate transport via proton symport, reversible (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GLYCLTt2rpp"]}, "metabolites": {"glyclt_p": -1.0, "glyclt_c": 1.0, "h_c": 1.0, "h_p": -1.0}, "id": "GLYCLTt2rpp", "gene_reaction_rule": "b3603 or b2975"}, 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"name": "Glucuronate isomerase (D-galacturonate)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GUI2"]}, "metabolites": {"tagur_c": 1.0, "galur_c": -1.0}, "id": "GUI2", "gene_reaction_rule": "b3092"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Glucuronate 1-phosphate phosphatase (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GUR1PPpp"]}, "metabolites": {"pi_p": 1.0, "h2o_p": -1.0, "glcur1p_p": -1.0, "glcur_p": 1.0}, "id": "GUR1PPpp", "gene_reaction_rule": ""}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Hydrogen peroxide transport via diffusion (external)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["H2O2tex"]}, "metabolites": {"h2o2_p": 1.0, "h2o2_e": -1.0}, "id": "H2O2tex", "gene_reaction_rule": "b0241 or b0929 or b1377 or b2215"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "H2O transport via diffusion (extracellular to periplasm)", 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"Membrane Lipid Metabolism", "name": "Beta-ketoacyl-ACP synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["KAS14"]}, "metabolites": {"acACP_c": -1.0, "ACP_c": 1.0, "malACP_c": -1.0, "h_c": -1.0, "actACP_c": 1.0, "co2_c": 1.0}, "id": "KAS14", "gene_reaction_rule": "b2323 or b1095"}, {"subsystem": "Membrane Lipid Metabolism", "name": "Beta-ketoacyl-ACP synthase (2)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["KAS15"]}, "metabolites": {"malACP_c": -1.0, "coa_c": 1.0, "h_c": -1.0, "accoa_c": -1.0, "actACP_c": 1.0, "co2_c": 1.0}, "id": "KAS15", "gene_reaction_rule": "b1091"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "3-deoxy-manno-octulosonate cytidylyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["KDOCT2"]}, "metabolites": {"ctp_c": -1.0, "ckdo_c": 1.0, "ppi_c": 1.0, "kdo_c": -1.0}, "id": "KDOCT2", "gene_reaction_rule": "b0918"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "3-deoxy-manno-octulosonate-8-phosphatase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["KDOPP"]}, "metabolites": {"kdo_c": 1.0, "kdo8p_c": -1.0, "h2o_c": -1.0, "pi_c": 1.0}, "id": "KDOPP", "gene_reaction_rule": "b3198"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "3-deoxy -D-manno-octulosonic -acid 8-phosphate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["KDOPS"]}, "metabolites": {"ara5p_c": -1.0, "kdo8p_c": 1.0, "h2o_c": -1.0, "pi_c": 1.0, "pep_c": -1.0}, "id": "KDOPS", "gene_reaction_rule": "b1215"}, {"subsystem": "Alternate Carbon Metabolism", "name": "3-keto-L-gulonate 6-phosphate decarboxylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["KG6PDC"]}, "metabolites": {"3dhgulnp_c": -1.0, "xu5p__L_c": 1.0, "co2_c": 1.0, "h_c": -1.0}, "id": "KG6PDC", "gene_reaction_rule": "b4196 or b3581"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Potassium ABC transporter (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["Kabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "k_p": -1.0, "h_c": 1.0, "adp_c": 1.0, "k_c": 1.0, "pi_c": 1.0}, "id": "Kabcpp", "gene_reaction_rule": "(b0698 and b0697 and b0696) or (b0698 and b0697 and b0696 and b4513)"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Potassium transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["Kt2pp"]}, "metabolites": {"k_p": -1.0, "k_c": 1.0, "h_c": 1.0, "h_p": -1.0}, "id": "Kt2pp", "gene_reaction_rule": "(b1291 and b3290 and b3849) or b1250 or (b1291 and b3290 and b1363) or b3747"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Potassium transport out via proton antiport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["Kt3pp"]}, "metabolites": {"k_p": 1.0, "k_c": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "Kt3pp", "gene_reaction_rule": "b1216 or b0842 or b3350 or b0047"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Potassium transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["Ktex"]}, "metabolites": {"k_p": 1.0, "k_e": -1.0}, "id": "Ktex", "gene_reaction_rule": "b0241 or b0929 or b1377 or b2215"}, {"subsystem": "Oxidative Phosphorylation", "name": "L-Lactate dehydrogenase (ubiquinone)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["L_DASH_LACD2"]}, "metabolites": {"q8h2_c": 1.0, "pyr_c": 1.0, "lac__L_c": -1.0, "q8_c": -1.0}, "id": "L_LACD2", "gene_reaction_rule": "b3605 or (b0306 and b0307 and b0308)"}, {"subsystem": "Oxidative Phosphorylation", "name": "L-Lactate dehydrogenase (menaquinone)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["L_DASH_LACD3"]}, "metabolites": {"mqn8_c": -1.0, "pyr_c": 1.0, "lac__L_c": -1.0, "mql8_c": 1.0}, "id": "L_LACD3", "gene_reaction_rule": "b3605 or (b0306 and b0307 and b0308)"}, {"subsystem": "Transport, Inner Membrane", "name": "L-lactate reversible transport via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["L_DASH_LACt2rpp"]}, "metabolites": {"lac__L_c": 1.0, "h_c": 1.0, "h_p": -1.0, "lac__L_p": -1.0}, "id": "L_LACt2rpp", "gene_reaction_rule": "b3603 or b2975"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "L-lactate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["L_DASH_LACtex"]}, "metabolites": {"lac__L_e": -1.0, "lac__L_p": 1.0}, "id": "L_LACtex", "gene_reaction_rule": "b0929 or b1377 or b2215 or b0241"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "4-amino-4-deoxy-L-arabinotransferase (LPS lipid A modification, periplasmic face of membrane))", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LA4NTpp"]}, "metabolites": {"acolipa_p": 1.0, "colipa_p": -1.0, "uLa4n_p": -1.0, "udcpp_p": 1.0}, "id": "LA4NTpp", "gene_reaction_rule": "b2257"}, {"subsystem": "Alternate Carbon Metabolism", "name": "B-galactosidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LACZ"]}, "metabolites": {"glc__D_c": 1.0, "lcts_c": -1.0, "h2o_c": -1.0, "gal_c": 1.0}, "id": "LACZ", "gene_reaction_rule": "b0344"}, {"subsystem": "Alternate Carbon Metabolism", "name": "B-galactosidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LACZpp"]}, "metabolites": {"gal_p": 1.0, "h2o_p": -1.0, "glc__D_p": 1.0, "lcts_p": -1.0}, "id": "LACZpp", "gene_reaction_rule": "b2132"}, {"subsystem": "Murein Recycling", "name": "L-alanyl-gamma-D-glutamyl-meso-diaminopimelate hydrolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LADGMDH"]}, "metabolites": {"h2o_c": -1.0, "LalaDglu_c": 1.0, "LalaDgluMdap_c": -1.0, "26dap__M_c": 1.0}, "id": "LADGMDH", "gene_reaction_rule": "b1326"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "L-alanyl-D-glutamate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["LALADGLUtex"]}, "metabolites": {"LalaDglu_p": 1.0, "LalaDglu_e": -1.0}, "id": "LALADGLUtex", "gene_reaction_rule": "b2215 or b1377 or b0241 or b0929"}, {"subsystem": "Transport, Inner Membrane", "name": "L-alanyl-D-glutamate transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LALADGLUtpp"]}, "metabolites": {"LalaDglu_p": -1.0, "LalaDglu_c": 1.0, "h_c": 1.0, "h_p": -1.0}, "id": "LALADGLUtpp", "gene_reaction_rule": "b1634 or b3496 or b4130 or b0709"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "L-alanyl-L-glutamate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["LALALGLUtex"]}, "metabolites": {"LalaLglu_p": 1.0, "LalaLglu_e": -1.0}, "id": "LALALGLUtex", "gene_reaction_rule": "b2215 or b1377 or b0241 or b0929"}, {"subsystem": "Transport, Inner Membrane", "name": "L-alanyl-L-glutamate transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LALALGLUtpp"]}, "metabolites": {"LalaLglu_p": -1.0, "LalaLglu_c": 1.0, "h_c": 1.0, "h_p": -1.0}, "id": "LALALGLUtpp", "gene_reaction_rule": "b1634 or b3496 or b4130 or b0709"}, {"subsystem": "Methylglyoxal Metabolism", "name": "D-Lactaldehyde:NAD+ 1-oxidoreductase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LALDO2x"]}, "metabolites": {"nad_c": 1.0, "nadh_c": -1.0, "h_c": -1.0, "mthgxl_c": -1.0, "lald__D_c": 1.0}, "id": "LALDO2x", "gene_reaction_rule": "b3945"}, {"subsystem": "Methylglyoxal Metabolism", "name": "L-Lactaldehyde:NADP+ 1-oxidoreductase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LALDO3"]}, "metabolites": {"nadp_c": 1.0, "nadph_c": -1.0, "h_c": -1.0, "lald__L_c": 1.0, "mthgxl_c": -1.0}, "id": "LALDO3", "gene_reaction_rule": ""}, {"subsystem": "Murein Recycling", "name": "L-alanyl-gamma-L-glutamate peptidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LALGP"]}, "metabolites": {"glu__L_c": 1.0, "ala__L_c": 1.0, "LalaLglu_c": -1.0, "h2o_c": -1.0}, "id": "LALGP", "gene_reaction_rule": "b0237"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Lactaldehyde dehydrogenase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LCADi"]}, "metabolites": {"h2o_c": -1.0, "lald__L_c": -1.0, "lac__L_c": 1.0, "h_c": 2.0, "nad_c": -1.0, "nadh_c": 1.0}, "id": "LCADi", "gene_reaction_rule": "b1415"}, {"subsystem": "Methylglyoxal Metabolism", "name": "Lacaldehyde reductase (R-propane-1,2-diol forming)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["LCARR"]}, "metabolites": {"nad_c": 1.0, "nadh_c": -1.0, "h_c": -1.0, "lald__D_c": -1.0, "12ppd__R_c": 1.0}, "id": "LCARR", "gene_reaction_rule": ""}, {"subsystem": "Alternate Carbon Metabolism", "name": "Lacaldehyde reductase (S-propane-1,2-diol forming)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["LCARS"]}, "metabolites": {"nadh_c": -1.0, "12ppd__S_c": 1.0, "nad_c": 1.0, "lald__L_c": -1.0, "h_c": -1.0}, "id": "LCARS", "gene_reaction_rule": "b2799"}, {"subsystem": "Transport, Inner Membrane", "name": "Lactose transport via proton aniport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LCTSt3ipp"]}, "metabolites": {"lcts_c": -1.0, "lcts_p": 1.0, "h_c": 1.0, "h_p": -1.0}, "id": "LCTSt3ipp", "gene_reaction_rule": "b2170 or b0070 or b1528"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Lactose transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["LCTStex"]}, "metabolites": {"lcts_p": 1.0, "lcts_e": -1.0}, "id": "LCTStex", "gene_reaction_rule": "b0241 or b0929 or b1377 or b2215"}, {"subsystem": "Transport, Inner Membrane", "name": "Lactose transport via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["LCTStpp"]}, "metabolites": {"lcts_c": 1.0, "lcts_p": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "LCTStpp", "gene_reaction_rule": "b0343"}, {"subsystem": "Pyruvate Metabolism", "name": "D-lactate dehydrogenase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["LDH_D"]}, "metabolites": {"pyr_c": 1.0, "nadh_c": 1.0, "lac__D_c": -1.0, "h_c": 1.0, "nad_c": -1.0}, "id": "LDH_D", "gene_reaction_rule": "b2133 or b1380"}, {"subsystem": "Oxidative Phosphorylation", "name": "D-lactate dehydrogenase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LDH_D2"]}, "metabolites": {"q8h2_c": 1.0, "pyr_c": 1.0, "lac__D_c": -1.0, "q8_c": -1.0}, "id": "LDH_D2", "gene_reaction_rule": "b2133"}, {"subsystem": "Valine, Leucine, and Isoleucine Metabolism", "name": "Leucine transaminase (irreversible)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LEUTAi"]}, "metabolites": {"akg_c": 1.0, "glu__L_c": -1.0, "4mop_c": -1.0, "leu__L_c": 1.0}, "id": "LEUTAi", "gene_reaction_rule": "b3770 or b4054"}, {"subsystem": "tRNA Charging", "name": "Leucyl-tRNA synthetase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LEUTRS"]}, "metabolites": {"leutrna_c": 1.0, "leu__L_c": -1.0, "atp_c": -1.0, "ppi_c": 1.0, "amp_c": 1.0, "trnaleu_c": -1.0}, "id": "LEUTRS", "gene_reaction_rule": "b0642"}, {"subsystem": "Transport, Inner Membrane", "name": "L-leucine transport via ABC system 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{"subsystem": "Transport, Outer Membrane Porin", "name": "Lipoate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["LIPOtex"]}, "metabolites": {"lipoate_e": -1.0, "lipoate_p": 1.0}, "id": "LIPOtex", "gene_reaction_rule": "b1377 or b2215 or b0929 or b0241"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "Lipid A disaccaride synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPADSS"]}, "metabolites": {"udp_c": 1.0, "u23ga_c": -1.0, "lipidAds_c": 1.0, "h_c": 1.0, "lipidX_c": -1.0}, "id": "LPADSS", "gene_reaction_rule": "b0182"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L1 (2-acylglycerophosphotidate, n-C12:0) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL1A120pp"]}, "metabolites": {"glyc3p_p": 1.0, "1ddecg3p_p": -1.0, "ddca_p": 1.0, "h_p": 1.0, "h2o_p": -1.0}, "id": "LPLIPAL1A120pp", "gene_reaction_rule": "b0494"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L1 (2-acylglycerophosphotidate, n-C14:0) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL1A140pp"]}, "metabolites": {"glyc3p_p": 1.0, "1tdecg3p_p": -1.0, "h_p": 1.0, "ttdca_p": 1.0, "h2o_p": -1.0}, "id": "LPLIPAL1A140pp", "gene_reaction_rule": "b0494"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L1 (2-acylglycerophosphotidate, n-C14:1) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL1A141pp"]}, "metabolites": {"glyc3p_p": 1.0, "1tdec7eg3p_p": -1.0, "ttdcea_p": 1.0, "h_p": 1.0, "h2o_p": -1.0}, "id": "LPLIPAL1A141pp", "gene_reaction_rule": "b0494"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L1 (2-acylglycerophosphotidate, n-C16:0) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": 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"name": "Lysophospholipase L1 (2-acylglycerophosphotidate, n-C18:1) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL1A181pp"]}, "metabolites": {"glyc3p_p": 1.0, "ocdcea_p": 1.0, "1odec11eg3p_p": -1.0, "h_p": 1.0, "h2o_p": -1.0}, "id": "LPLIPAL1A181pp", "gene_reaction_rule": "b0494"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L1 (2-acylglycerophosphoethanolamine, n-C12:0) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL1E120pp"]}, "metabolites": {"1agpe120_p": -1.0, "ddca_p": 1.0, "g3pe_p": 1.0, "h_p": 1.0, "h2o_p": -1.0}, "id": "LPLIPAL1E120pp", "gene_reaction_rule": "b0494"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L1 (2-acylglycerophosphoethanolamine, n-C14:0) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL1E140pp"]}, "metabolites": {"h2o_p": -1.0, "1agpe140_p": -1.0, 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"b0494"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L1 (2-acylglycerophosphoglycerol, n-C12:0) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL1G120pp"]}, "metabolites": {"h2o_p": -1.0, "g3pg_p": 1.0, "ddca_p": 1.0, "h_p": 1.0, "1agpg120_p": -1.0}, "id": "LPLIPAL1G120pp", "gene_reaction_rule": "b0494"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L1 (2-acylglycerophosphoglycerol, n-C14:0) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL1G140pp"]}, "metabolites": {"h2o_p": -1.0, "g3pg_p": 1.0, "1agpg140_p": -1.0, "h_p": 1.0, "ttdca_p": 1.0}, "id": "LPLIPAL1G140pp", "gene_reaction_rule": "b0494"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L1 (2-acylglycerophosphoglycerol, n-C14:1) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL1G141pp"]}, 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(2-acylglycerophosphoglycerol, n-C18:0) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL1G180pp"]}, "metabolites": {"1agpg180_p": -1.0, "h2o_p": -1.0, "g3pg_p": 1.0, "ocdca_p": 1.0, "h_p": 1.0}, "id": "LPLIPAL1G180pp", "gene_reaction_rule": "b0494"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L1 (2-acylglycerophosphoglycerol, n-C18:1) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL1G181pp"]}, "metabolites": {"h2o_p": -1.0, "ocdcea_p": 1.0, "g3pg_p": 1.0, "h_p": 1.0, "1agpg181_p": -1.0}, "id": "LPLIPAL1G181pp", "gene_reaction_rule": "b0494"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L2 (2-acylglycerophosphotidate, n-C12:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL2A120"]}, "metabolites": {"ddca_c": 1.0, "glyc3p_c": 1.0, "2ddecg3p_c": -1.0, "h2o_c": -1.0, "h_c": 2.0}, "id": "LPLIPAL2A120", "gene_reaction_rule": "b3825"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L2 (2-acylglycerophosphotidate, n-C14:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL2A140"]}, "metabolites": {"glyc3p_c": 1.0, "2tdecg3p_c": -1.0, "h_c": 2.0, "h2o_c": -1.0, "ttdca_c": 1.0}, "id": "LPLIPAL2A140", "gene_reaction_rule": "b3825"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L2 (2-acylglycerophosphotidate, n-C14:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL2A141"]}, "metabolites": {"h_c": 2.0, "h2o_c": -1.0, "glyc3p_c": 1.0, "2tdec7eg3p_c": -1.0, "ttdcea_c": 1.0}, "id": "LPLIPAL2A141", "gene_reaction_rule": "b3825"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L2 (2-acylglycerophosphotidate, n-C16:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL2A160"]}, "metabolites": 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2-acyl-glycerophosphoglycerol, n-C12:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL2ATG120"]}, "metabolites": {"g3pg_c": 1.0, "apg120_c": 1.0, "2agpg120_c": -1.0, "pg120_c": -1.0}, "id": "LPLIPAL2ATG120", "gene_reaction_rule": "b3825"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L2 (acyltransferase, 2-acyl-glycerophosphoglycerol, n-C14:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL2ATG140"]}, "metabolites": {"g3pg_c": 1.0, "2agpg140_c": -1.0, "apg140_c": 1.0, "pg140_c": -1.0}, "id": "LPLIPAL2ATG140", "gene_reaction_rule": "b3825"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L2 (acyltransferase, 2-acyl-glycerophosphoglycerol, n-C14:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL2ATG141"]}, "metabolites": {"pg141_c": -1.0, "g3pg_c": 1.0, "2agpg141_c": -1.0, "apg141_c": 1.0}, "id": "LPLIPAL2ATG141", 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["LPLIPAL2ATG180"]}, "metabolites": {"g3pg_c": 1.0, "pg180_c": -1.0, "2agpg180_c": -1.0, "apg180_c": 1.0}, "id": "LPLIPAL2ATG180", "gene_reaction_rule": "b3825"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L2 (acyltransferase, 2-acyl-glycerophosphoglycerol, n-C18:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL2ATG181"]}, "metabolites": {"apg181_c": 1.0, "g3pg_c": 1.0, "pg181_c": -1.0, "2agpg181_c": -1.0}, "id": "LPLIPAL2ATG181", "gene_reaction_rule": "b3825"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L2 (2-acylglycerophosphoethanolamine, n-C12:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL2E120"]}, "metabolites": {"ddca_c": 1.0, "2agpe120_c": -1.0, "h_c": 1.0, "h2o_c": -1.0, "g3pe_c": 1.0}, "id": "LPLIPAL2E120", "gene_reaction_rule": "b3825"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L2 (2-acylglycerophosphoethanolamine, n-C14:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL2E140"]}, "metabolites": {"h_c": 1.0, "h2o_c": -1.0, "2agpe140_c": -1.0, "ttdca_c": 1.0, "g3pe_c": 1.0}, "id": "LPLIPAL2E140", "gene_reaction_rule": "b3825"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L2 (2-acylglycerophosphoethanolamine, n-C14:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL2E141"]}, "metabolites": {"h2o_c": -1.0, "2agpe141_c": -1.0, "h_c": 1.0, "ttdcea_c": 1.0, "g3pe_c": 1.0}, "id": "LPLIPAL2E141", "gene_reaction_rule": "b3825"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L2 (2-acylglycerophosphoethanolamine, n-C16:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL2E160"]}, "metabolites": {"h2o_c": -1.0, "hdca_c": 1.0, "h_c": 1.0, "2agpe160_c": -1.0, "g3pe_c": 1.0}, "id": "LPLIPAL2E160", 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{"ocdcea_c": 1.0, "h2o_c": -1.0, "2agpe181_c": -1.0, "h_c": 1.0, "g3pe_c": 1.0}, "id": "LPLIPAL2E181", "gene_reaction_rule": "b3825"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L2 (2-acylglycerophosphoglycerol, n-C12:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL2G120"]}, "metabolites": {"ddca_c": 1.0, "g3pg_c": 1.0, "h2o_c": -1.0, "2agpg120_c": -1.0, "h_c": 1.0}, "id": "LPLIPAL2G120", "gene_reaction_rule": "b3825"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L2 (2-acylglycerophosphoglycerol, n-C14:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL2G140"]}, "metabolites": {"g3pg_c": 1.0, "2agpg140_c": -1.0, "ttdca_c": 1.0, "h2o_c": -1.0, "h_c": 1.0}, "id": "LPLIPAL2G140", "gene_reaction_rule": "b3825"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L2 (2-acylglycerophosphoglycerol, n-C14:1)", "upper_bound": 1000.0, 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"Lysophospholipase L2 (2-acylglycerophosphoglycerol, n-C18:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL2G180"]}, "metabolites": {"g3pg_c": 1.0, "h2o_c": -1.0, "h_c": 1.0, "2agpg180_c": -1.0, "ocdca_c": 1.0}, "id": "LPLIPAL2G180", "gene_reaction_rule": "b3825"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L2 (2-acylglycerophosphoglycerol, n-C18:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL2G181"]}, "metabolites": {"ocdcea_c": 1.0, "h2o_c": -1.0, "2agpg181_c": -1.0, "h_c": 1.0, "g3pg_c": 1.0}, "id": "LPLIPAL2G181", "gene_reaction_rule": "b3825"}, {"subsystem": "Glycine and Serine Metabolism", "name": "L-serine dehydrogenase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["LSERDHr"]}, "metabolites": {"2amsa_c": 1.0, "ser__L_c": -1.0, "nadp_c": -1.0, "nadph_c": 1.0, "h_c": 1.0}, "id": "LSERDHr", "gene_reaction_rule": "b1539"}, {"subsystem": "Threonine and Lysine Metabolism", "name": "Lysine decarboxylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LYSDC"]}, "metabolites": {"15dap_c": 1.0, "co2_c": 1.0, "lys__L_c": -1.0, "h_c": -1.0}, "id": "LYSDC", "gene_reaction_rule": "b0186 or b4131"}, {"subsystem": "tRNA Charging", "name": "Lysyl-tRNA synthetase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LYSTRS"]}, "metabolites": {"trnalys_c": -1.0, "lys__L_c": -1.0, "atp_c": -1.0, "ppi_c": 1.0, "amp_c": 1.0, "lystrna_c": 1.0}, "id": "LYSTRS", "gene_reaction_rule": "b4129 or b2890"}, {"subsystem": "Transport, Inner Membrane", "name": "L-lysine transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LYSabcpp"]}, "metabolites": {"h2o_c": -1.0, "lys__L_c": 1.0, "atp_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "lys__L_p": -1.0, "pi_c": 1.0}, "id": "LYSabcpp", "gene_reaction_rule": "b2310 and b2307 and b2306 and b2308"}, {"subsystem": "Transport, Inner Membrane", "name": "L-lysine transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LYSt2pp"]}, "metabolites": {"lys__L_c": 1.0, "h_c": 1.0, "h_p": -1.0, "lys__L_p": -1.0}, "id": "LYSt2pp", "gene_reaction_rule": "b2156"}, {"subsystem": "Transport, Inner Membrane", "name": "L-lysine transport out via proton antiport (cytoplasm to periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LYSt3pp"]}, "metabolites": {"lys__L_c": -1.0, "h_c": 1.0, "h_p": -1.0, "lys__L_p": 1.0}, "id": "LYSt3pp", "gene_reaction_rule": "b2923"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "L-lysine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["LYStex"]}, "metabolites": {"lys__L_e": -1.0, "lys__L_p": 1.0}, "id": "LYStex", "gene_reaction_rule": "b0241 or b0929 or b1377 or b2215"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Lyxose isomerase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LYXI"]}, "metabolites": {"xylu__L_c": 1.0, "lyx__L_c": -1.0}, "id": "LYXI", "gene_reaction_rule": "b3903"}, {"subsystem": "Transport, Inner Membrane", "name": "L-Lyxose transport via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LYXt2pp"]}, "metabolites": {"lyx__L_p": -1.0, "h_c": 1.0, "h_p": -1.0, "lyx__L_c": 1.0}, "id": "LYXt2pp", "gene_reaction_rule": "b3907"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "L-Lyxose transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["LYXtex"]}, "metabolites": {"lyx__L_e": -1.0, "lyx__L_p": 1.0}, "id": "LYXtex", "gene_reaction_rule": "b0241 or b0929 or b1377 or b2215"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Mannitol-1-phosphate 5-dehydrogenase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["M1PD"]}, "metabolites": {"h_c": 1.0, "nadh_c": 1.0, "mnl1p_c": -1.0, "nad_c": -1.0, "f6p_c": 1.0}, "id": "M1PD", "gene_reaction_rule": "b3600"}, {"subsystem": "Membrane Lipid Metabolism", "name": "Malonyl-ACP decarboxylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MACPD"]}, "metabolites": {"acACP_c": 1.0, "co2_c": 1.0, "malACP_c": -1.0, "h_c": -1.0}, "id": "MACPD", "gene_reaction_rule": "b2323"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Malonyl-CoA methyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MALCOAMT"]}, "metabolites": {"ahcys_c": 1.0, "malcoame_c": 1.0, "malcoa_c": -1.0, "amet_c": -1.0}, "id": "MALCOAMT", "gene_reaction_rule": "b0777"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Malate decarboxylating oxidoreductase (decarboxylating)", "upper_bound": 1000.0, 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"Transport, Inner Membrane", "name": "Maltotriose transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MALTTRabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "malttr_p": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "malttr_c": 1.0}, "id": "MALTTRabcpp", "gene_reaction_rule": "b4034 and b4033 and b4032 and b4035"}, {"subsystem": "Transport, Outer Membrane", "name": "Maltotriose transport via diffusion (extracellular to periplasm) irreversible", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MALTTRtexi"]}, "metabolites": {"malttr_e": -1.0, "malttr_p": 1.0}, "id": "MALTTRtexi", "gene_reaction_rule": "b4036"}, {"subsystem": "Transport, Inner Membrane", "name": "Maltotetraose transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MALTTTRabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "maltttr_c": 1.0, "h_c": 1.0, "adp_c": 1.0, 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1.0, "met__L_p": -1.0}, "id": "METabcpp", "gene_reaction_rule": "b0198 and b0199 and b0197"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "L-methionine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["METtex"]}, "metabolites": {"met__L_e": -1.0, "met__L_p": 1.0}, "id": "METtex", "gene_reaction_rule": "b0241 or b0929 or b1377 or b2215"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Magnesium (Mg+2) transport in/out via proton antiport (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MG2t3_2pp"]}, "metabolites": {"mg2_p": -1.0, "h_c": -2.0, "h_p": 2.0, "mg2_c": 1.0}, "id": "MG2t3_2pp", "gene_reaction_rule": ""}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Magnesium (Mg+2) transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MG2tex"]}, "metabolites": {"mg2_e": -1.0, "mg2_p": 1.0}, "id": "MG2tex", "gene_reaction_rule": "b0241 or b0929 or b1377 or b2215"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Magnesium (+2) transport in via diffusion", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MG2tpp"]}, "metabolites": {"mg2_c": 1.0, "mg2_p": -1.0}, "id": "MG2tpp", "gene_reaction_rule": "b3816"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Magnesium (Mg+2) ABC transporter (ubtake, periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MG2uabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "mg2_p": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "mg2_c": 1.0}, "id": "MG2uabcpp", "gene_reaction_rule": "b4242"}, {"subsystem": "Methylglyoxal Metabolism", "name": "Methylglyoxal synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MGSA"]}, "metabolites": {"dhap_c": -1.0, "pi_c": 1.0, "mthgxl_c": 1.0}, "id": "MGSA", "gene_reaction_rule": "b0963"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "Myo-inositol 1-phosphatase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MI1PP"]}, "metabolites": {"mi1p__D_c": -1.0, "pi_c": 1.0, "inost_c": 1.0, "h2o_c": -1.0}, "id": "MI1PP", "gene_reaction_rule": "b2533"}, {"subsystem": "Alternate Carbon Metabolism", "name": "2-methylisocitrate dehydratase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MICITDr"]}, "metabolites": {"2mcacn_c": -1.0, "h2o_c": -1.0, "micit_c": 1.0}, "id": "MICITDr", "gene_reaction_rule": "b0118"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Minocycline transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MINCYCtex"]}, "metabolites": {"mincyc_e": -1.0, "mincyc_p": 1.0}, "id": "MINCYCtex", "gene_reaction_rule": "b1377 or b2215 or b0929 or b0241"}, {"subsystem": "Transport, Outer Membrane", "name": "Minocycline transport via TolC system", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MINCYCtpp"]}, "metabolites": {"mincyc_p": -1.0, "mincyc_e": 1.0, "h_c": 1.0, "h_p": -1.0}, "id": "MINCYCtpp", "gene_reaction_rule": "(b0463 and b0462 and b3035) or (b0463 and b2470 and b3035)"}, {"subsystem": "Transport, Outer Membrane", "name": "Myo-inositol phosphate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MINOHPtexi"]}, "metabolites": {"minohp_p": 1.0, "minohp_e": -1.0}, "id": "MINOHPtexi", "gene_reaction_rule": ""}, {"subsystem": "Murein Biosynthesis", "name": "Murein L,D-carboxypeptidase (murein5px4p) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MLDCP1App"]}, "metabolites": {"h2o_p": -1.0, "murein3px4p_p": 1.0, "alaala_p": 1.0, "murein5px4p_p": -1.0}, "id": "MLDCP1App", "gene_reaction_rule": ""}, {"subsystem": "Murein Biosynthesis", "name": "Murein L,D-carboxypeptidase (murein4p4p) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MLDCP1Bpp"]}, "metabolites": {"h2o_p": -1.0, "ala__D_p": 1.0, "murein4p3p_p": 1.0, "murein4p4p_p": -1.0}, "id": "MLDCP1Bpp", "gene_reaction_rule": ""}, {"subsystem": "Murein Biosynthesis", "name": "Murein L,D-carboxypeptidase (murein5p5p) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MLDCP2App"]}, "metabolites": {"h2o_p": -1.0, "murein5p5p_p": -1.0, "alaala_p": 1.0, "murein5p3p_p": 1.0}, "id": "MLDCP2App", "gene_reaction_rule": ""}, {"subsystem": "Murein Biosynthesis", "name": "Murein L,D-carboxypeptidase (murein4p3p) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MLDCP2Bpp"]}, "metabolites": {"h2o_p": -1.0, "ala__D_p": 1.0, "murein4p3p_p": -1.0, "murein3p3p_p": 1.0}, "id": "MLDCP2Bpp", "gene_reaction_rule": ""}, {"subsystem": "Murein Biosynthesis", "name": "Murein L,D-carboxypeptidase (murein5px3p) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MLDCP3App"]}, "metabolites": {"h2o_p": -1.0, "murein3px3p_p": 1.0, "murein5px3p_p": -1.0, "alaala_p": 1.0}, "id": "MLDCP3App", "gene_reaction_rule": ""}, {"subsystem": "Murein Recycling", "name": "Murein L,D-endopeptidase (murein3px3p) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MLDEP1pp"]}, "metabolites": {"h2o_p": -1.0, "murein3px3p_p": -1.0, "murein3p3p_p": 1.0}, "id": "MLDEP1pp", "gene_reaction_rule": ""}, {"subsystem": "Murein Recycling", "name": "Murein L,D-endopeptidase (murein5px3p) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MLDEP2pp"]}, "metabolites": {"h2o_p": -1.0, "murein5px3p_p": -1.0, "murein5p3p_p": 1.0}, "id": "MLDEP2pp", "gene_reaction_rule": ""}, {"subsystem": "Alternate Carbon Metabolism", "name": "Maltodextrin glucosidase (maltotriose)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MLTG1"]}, "metabolites": {"glc__D_c": 1.0, "malt_c": 1.0, "h2o_c": -1.0, "malttr_c": -1.0}, "id": "MLTG1", "gene_reaction_rule": "b0403"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Maltodextrin glucosidase (maltotetraose)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MLTG2"]}, "metabolites": {"glc__D_c": 1.0, "h2o_c": -1.0, "malttr_c": 1.0, "maltttr_c": -1.0}, "id": "MLTG2", "gene_reaction_rule": "b0403"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Maltodextrin glucosidase (maltopentaose)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MLTG3"]}, "metabolites": {"glc__D_c": 1.0, "maltpt_c": -1.0, "h2o_c": -1.0, "maltttr_c": 1.0}, "id": "MLTG3", "gene_reaction_rule": "b0403"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Maltodextrin glucosidase (maltohexaose)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MLTG4"]}, "metabolites": {"glc__D_c": 1.0, "maltpt_c": 1.0, "h2o_c": -1.0, "malthx_c": -1.0}, "id": "MLTG4", "gene_reaction_rule": "b0403"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Maltodextrin glucosidase (maltoheptaose)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MLTG5"]}, "metabolites": {"glc__D_c": 1.0, "malthx_c": 1.0, "h2o_c": -1.0, "malthp_c": -1.0}, "id": "MLTG5", "gene_reaction_rule": "b0403"}, {"subsystem": "Murein Recycling", "name": "Murein lytic transglycosylase (murein4p4p) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MLTGY1pp"]}, "metabolites": {"murein4p4p_p": -1.0, "anhgm4p_p": 2.0}, "id": "MLTGY1pp", "gene_reaction_rule": "b2558 or b2963 or b4392 or b2813 or b2701 or b1193"}, {"subsystem": "Murein Recycling", "name": "Murein lytic transglycosylase (murein4p3p) (periplasm)", 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{"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Molybdopterin cytidine dinucleotide synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MOCDS"]}, "metabolites": {"ctp_c": -1.0, "ppi_c": 1.0, "mococdp_c": 1.0, "moco_c": -1.0, "h_c": -1.0}, "id": "MOCDS", "gene_reaction_rule": "b2877"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Molybdenum cofactor synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MOCOS"]}, "metabolites": {"cu2_c": 1.0, "h2o_c": 1.0, "mobd_c": -1.0, "moco_c": 1.0, "h_c": -2.0, "mptamp_c": -1.0, "amp_c": 1.0}, "id": "MOCOS", "gene_reaction_rule": "b0827"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Molybdopterin guanine dinucleotide synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MOGDS"]}, "metabolites": {"mocogdp_c": 1.0, "ppi_c": 1.0, "gtp_c": -1.0, "h_c": -1.0, "moco_c": -1.0}, "id": 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"b0009"}, {"subsystem": "Murein Biosynthesis", "name": "Murein polymerizing transglycosylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MPTG"]}, "metabolites": {"udcpdp_c": 2.0, "uaagmda_c": -2.0, "h_c": 2.0, "murein5p5p_p": 1.0}, "id": "MPTG", "gene_reaction_rule": "(b3396 and b1069) or (b0149 and b1069) or (b1069 and b2519)"}, {"subsystem": "Murein Biosynthesis", "name": "Murein polymerizing transglycosylase 2 (three linked units)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MPTG2"]}, "metabolites": {"udcpdp_c": 1.0, "murein5p5p_p": -1.0, "murein5p5p5p_p": 1.0, "h_c": 1.0, "uaagmda_c": -1.0}, "id": "MPTG2", "gene_reaction_rule": "(b3396 and b1069) or (b0149 and b1069) or (b1069 and b2519)"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Molybdopterin synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MPTS"]}, "metabolites": {"cu2_c": -1.0, "mpt_c": 1.0, 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-1.0, "mso3_c": 1.0, "atp_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "mso3_p": -1.0}, "id": "MSO3abcpp", "gene_reaction_rule": "b0936 and b0933 and b0934"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Methanesulfonate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MSO3tex"]}, "metabolites": {"mso3_e": -1.0, "mso3_p": 1.0}, "id": "MSO3tex", "gene_reaction_rule": "b0241 or b0929 or b1377 or b2215"}, {"subsystem": "Arginine and Proline Metabolism", "name": "Methylthioadenosine nucleosidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MTAN"]}, "metabolites": {"ade_c": 1.0, "h2o_c": -1.0, "5mta_c": -1.0, "5mtr_c": 1.0}, "id": "MTAN", "gene_reaction_rule": "b0159"}, {"subsystem": "Folate Metabolism", "name": "Methenyltetrahydrofolate cyclohydrolase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MTHFC"]}, "metabolites": {"h_c": 1.0, "h2o_c": -1.0, "10fthf_c": 1.0, "methf_c": -1.0}, "id": "MTHFC", "gene_reaction_rule": "b0529"}, {"subsystem": "Folate Metabolism", "name": "Methylenetetrahydrofolate dehydrogenase (NADP)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MTHFD"]}, "metabolites": {"nadp_c": -1.0, "nadph_c": 1.0, "methf_c": 1.0, "mlthf_c": -1.0}, "id": "MTHFD", "gene_reaction_rule": "b0529"}, {"subsystem": "Folate Metabolism", "name": "5,10-methylenetetrahydrofolate reductase (NADH)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MTHFR2"]}, "metabolites": {"mlthf_c": -1.0, "nadh_c": -1.0, "5mthf_c": 1.0, "nad_c": 1.0, "h_c": -2.0}, "id": "MTHFR2", "gene_reaction_rule": "b3941"}, {"subsystem": "Methionine Metabolism", "name": "(2R,4S)-2-methyl-2,3,3,4-tetrahydroxytetrahydrofuran synthesis (spontaneous)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MTHTHFSs"]}, "metabolites": {"h2o_c": -1.0, 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"id": "N2Otpp", "gene_reaction_rule": "s0001"}, {"subsystem": "Arginine and Proline Metabolism", "name": "N-acetylornithine deacetylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NACODA"]}, "metabolites": {"glu5sa_c": 1.0, "ac_c": 1.0, "h2o_c": -1.0, "acg5sa_c": -1.0}, "id": "NACODA", "gene_reaction_rule": "b3957"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Nicotinic acid transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["NACtex"]}, "metabolites": {"nac_e": -1.0, "nac_p": 1.0}, "id": "NACtex", "gene_reaction_rule": "b0241 or b0929 or b1377 or b2215"}, {"subsystem": "Transport, Inner Membrane", "name": "Nicotinic acid uptake (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NACtpp"]}, "metabolites": {"nac_c": 1.0, "nac_p": -1.0}, "id": "NACtpp", "gene_reaction_rule": ""}, {"subsystem": "Cofactor and Prosthetic 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b2281 and b2282 and b2283 and b2284 and b2285 and b2286 and b2287 and b2288"}, {"subsystem": "Oxidative Phosphorylation", "name": "NADH dehydrogenase (menaquinone-8 & 3 protons) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADH17pp"]}, "metabolites": {"mqn8_c": -1.0, "h_p": 3.0, "h_c": -4.0, "nad_c": 1.0, "nadh_c": -1.0, "mql8_c": 1.0}, "id": "NADH17pp", "gene_reaction_rule": "b2276 and b2277 and b2278 and b2279 and b2280 and b2281 and b2282 and b2283 and b2284 and b2285 and b2286 and b2287 and b2288"}, {"subsystem": "Oxidative Phosphorylation", "name": "NADH dehydrogenase (demethylmenaquinone-8 & 3 protons) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADH18pp"]}, "metabolites": {"2dmmq8_c": -1.0, "h_p": 3.0, "2dmmql8_c": 1.0, "h_c": -4.0, "nad_c": 1.0, "nadh_c": -1.0}, "id": "NADH18pp", "gene_reaction_rule": "b2276 and b2277 and b2278 and b2279 and b2280 and b2281 and b2282 and b2283 and b2284 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{"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "NAD nucleosidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADN"]}, "metabolites": {"h2o_c": -1.0, "nad_c": -1.0, "h_c": 1.0, "adprib_c": 1.0, "ncam_c": 1.0}, "id": "NADN", "gene_reaction_rule": ""}, {"subsystem": "Oxidative Phosphorylation", "name": "NADPH Quinone Reductase (Ubiquinone-8)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADPHQR2"]}, "metabolites": {"q8h2_c": 1.0, "nadp_c": 1.0, "nadph_c": -1.0, "h_c": -1.0, "q8_c": -1.0}, "id": "NADPHQR2", "gene_reaction_rule": "b3028"}, {"subsystem": "Oxidative Phosphorylation", "name": "NADPH Quinone Reductase (Menaquinone-8)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADPHQR3"]}, "metabolites": {"nadph_c": -1.0, "nadp_c": 1.0, "mqn8_c": -1.0, "h_c": -1.0, "mql8_c": 1.0}, "id": "NADPHQR3", "gene_reaction_rule": "b3028"}, {"subsystem": "Oxidative Phosphorylation", "name": "NADPH Quinone Reductase (2-Demethylmenaquinone-8)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADPHQR4"]}, "metabolites": {"nadp_c": 1.0, "nadph_c": -1.0, "h_c": -1.0, "2dmmql8_c": 1.0, "2dmmq8_c": -1.0}, "id": "NADPHQR4", "gene_reaction_rule": "b3028"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "NADP phosphatase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADPPPS"]}, "metabolites": {"h2o_c": -1.0, "nadp_c": -1.0, "pi_c": 1.0, "nad_c": 1.0}, "id": "NADPPPS", "gene_reaction_rule": ""}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "NAD synthase (nh3)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADS1"]}, "metabolites": {"dnad_c": -1.0, "atp_c": -1.0, "ppi_c": 1.0, "h_c": 1.0, "nad_c": 1.0, "nh4_c": -1.0, "amp_c": 1.0}, "id": "NADS1", "gene_reaction_rule": "b1740"}, {"subsystem": "Oxidative Phosphorylation", "name": "NAD 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{"subsystem": "Nucleotide Salvage Pathway", "name": "Nucleoside-diphosphate kinase (ATP:GDP)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["NDPK1"]}, "metabolites": {"gdp_c": -1.0, "gtp_c": 1.0, "atp_c": -1.0, "adp_c": 1.0}, "id": "NDPK1", "gene_reaction_rule": "b0474 or b2518"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Nucleoside-diphosphate kinase (ATP:UDP)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["NDPK2"]}, "metabolites": {"utp_c": 1.0, "udp_c": -1.0, "atp_c": -1.0, "adp_c": 1.0}, "id": "NDPK2", "gene_reaction_rule": "b0474 or b2518"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Nucleoside-diphosphate kinase (ATP:CDP)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["NDPK3"]}, "metabolites": {"ctp_c": 1.0, "cdp_c": -1.0, "adp_c": 1.0, "atp_c": -1.0}, "id": "NDPK3", "gene_reaction_rule": "b2518 or b0474"}, {"subsystem": "Nucleotide Salvage Pathway", "name": 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"Ornithine Decarboxylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ORNDC"]}, "metabolites": {"ptrc_c": 1.0, "co2_c": 1.0, "orn_c": -1.0, "h_c": -1.0}, "id": "ORNDC", "gene_reaction_rule": "b2965 or b0693"}, {"subsystem": "Transport, Inner Membrane", "name": "Ornithine transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ORNabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "orn_p": -1.0, "orn_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0}, "id": "ORNabcpp", "gene_reaction_rule": "b2310 and b2307 and b2306 and b2308"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Ornithine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ORNtex"]}, "metabolites": {"orn_e": -1.0, "orn_p": 1.0}, "id": "ORNtex", "gene_reaction_rule": "b0241 or b0929 or b1377 or b2215"}, {"subsystem": "Transport, Inner 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{"subsystem": "Anaplerotic Reactions", "name": "Phosphoenolpyruvate carboxykinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PPCK"]}, "metabolites": {"pep_c": 1.0, "co2_c": 1.0, "atp_c": -1.0, "oaa_c": -1.0, "adp_c": 1.0}, "id": "PPCK", "gene_reaction_rule": "b3403"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Propanoyl-CoA: succinate CoA-transferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PPCSCT"]}, "metabolites": {"succ_c": -1.0, "succoa_c": 1.0, "ppa_c": 1.0, "ppcoa_c": -1.0}, "id": "PPCSCT", "gene_reaction_rule": "b2920"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Guanosine-3',5'-bis(diphosphate) 3'-diphosphatase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PPGPPDP"]}, "metabolites": {"ppi_c": 1.0, "gdp_c": 1.0, "ppgpp_c": -1.0, "h2o_c": -1.0}, "id": "PPGPPDP", "gene_reaction_rule": "b3650"}, {"subsystem": "Oxidative Phosphorylation", "name": "Polyphosphate kinase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["PPK2r"]}, "metabolites": {"pppi_c": 1.0, "ppi_c": -1.0, "adp_c": 1.0, "atp_c": -1.0}, "id": "PPK2r", "gene_reaction_rule": "b2501"}, {"subsystem": "Oxidative Phosphorylation", "name": "Polyphosphate kinase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["PPKr"]}, "metabolites": {"ppi_c": 1.0, "pi_c": -1.0, "atp_c": -1.0, "adp_c": 1.0}, "id": "PPKr", "gene_reaction_rule": "b2501"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Phosphopentomutase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["PPM"]}, "metabolites": {"r5p_c": 1.0, "r1p_c": -1.0}, "id": "PPM", "gene_reaction_rule": "b3380 or b4383"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Phosphopentomutase 2 (deoxyribose)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["PPM2"]}, "metabolites": {"2dr1p_c": 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-1.0}, "id": "R5Ptex", "gene_reaction_rule": "b0241 or b0929 or b1377 or b2215"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Riboflavin kinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["RBFK"]}, "metabolites": {"ribflv_c": -1.0, "fmn_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "atp_c": -1.0}, "id": "RBFK", "gene_reaction_rule": "b0025"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Riboflavin synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["RBFSa"]}, "metabolites": {"4r5au_c": -1.0, "h2o_c": 2.0, "dmlz_c": 1.0, "pi_c": 1.0, "db4p_c": -1.0}, "id": "RBFSa", "gene_reaction_rule": "b1662"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Riboflavin synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["RBFSb"]}, "metabolites": {"4r5au_c": 1.0, "dmlz_c": -2.0, "ribflv_c": 1.0}, "id": "RBFSb", "gene_reaction_rule": "b0415"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Ribokinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["RBK"]}, "metabolites": {"adp_c": 1.0, "r5p_c": 1.0, "h_c": 1.0, "atp_c": -1.0, "rib__D_c": -1.0}, "id": "RBK", "gene_reaction_rule": "b3752"}, {"subsystem": "Alternate Carbon Metabolism", "name": "L-ribulokinase (L-ribulose)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["RBK_L1"]}, "metabolites": {"rbl__L_c": -1.0, "adp_c": 1.0, "ru5p__L_c": 1.0, "atp_c": -1.0, "h_c": 1.0}, "id": "RBK_L1", "gene_reaction_rule": "b0063"}, {"subsystem": "Alternate Carbon Metabolism", "name": "L-ribulose-phosphate 4-epimerase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["RBP4E"]}, "metabolites": {"xu5p__D_c": 1.0, "ru5p__L_c": -1.0}, "id": "RBP4E", "gene_reaction_rule": "b4198 or b3583 or b0061"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Ring 1,2-epoxyphenylacetyl-CoA isomerase (oxepin-CoA forming)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["REPHACCOAI"]}, "metabolites": {"rephaccoa_c": -1.0, "2oxpaccoa_c": 1.0}, "id": "REPHACCOAI", "gene_reaction_rule": "b1394"}, {"subsystem": "Transport, Outer Membrane", "name": "Rifampin transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["RFAMPtex"]}, "metabolites": {"rfamp_e": -1.0, "rfamp_p": 1.0}, "id": "RFAMPtex", "gene_reaction_rule": "s0001"}, {"subsystem": "Transport, Outer Membrane", "name": "Rifampin transport via TolC system", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["RFAMPtpp"]}, "metabolites": {"rfamp_e": 1.0, "rfamp_p": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "RFAMPtpp", "gene_reaction_rule": "(b0463 and b0462 and b3035) or (b0463 and b2470 and b3035)"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "Rhamnosyltransferase I (LPS core biosynthesis)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["RHAT1"]}, "metabolites": {"dtdprmn_c": -1.0, "icolipa_c": 1.0, "dtdp_c": 1.0, "h_c": 1.0, "kphphhlipa_c": -1.0}, "id": "RHAT1", "gene_reaction_rule": "b3629"}, {"subsystem": "Methionine Metabolism", "name": "S-ribosylhomocysteine cleavage enzyme", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["RHCCE"]}, "metabolites": {"hcys__L_c": 1.0, "rhcys_c": -1.0, "dhptd_c": 1.0}, "id": "RHCCE", "gene_reaction_rule": "b2687"}, {"subsystem": "Transport, Inner Membrane", "name": "D-ribose transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["RIBabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "rib__D_p": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "rib__D_c": 1.0}, "id": "RIBabcpp", "gene_reaction_rule": "(b4231 and b4227 and b4485 and b4230) or (b3749 and b3751 and b3750 and b3748) or (b4087 and b4088 and 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{"original_bigg_ids": ["RNDR1"]}, "metabolites": {"dadp_c": 1.0, "trdox_c": 1.0, "trdrd_c": -1.0, "h2o_c": 1.0, "adp_c": -1.0}, "id": "RNDR1", "gene_reaction_rule": "((b2234 and b2235) and b2582) or ((b2234 and b2235) and b3781)"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Ribonucleoside-diphosphate reductase (ADP) (glutaredoxin)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["RNDR1b"]}, "metabolites": {"dadp_c": 1.0, "h2o_c": 1.0, "grxrd_c": -1.0, "adp_c": -1.0, "grxox_c": 1.0}, "id": "RNDR1b", "gene_reaction_rule": "(b1064 and (b2675 and b2676)) or (b3610 and (b2675 and b2676)) or (b1654 and (b2675 and b2676)) or (b0849 and (b2675 and b2676))"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Ribonucleoside-diphosphate reductase (GDP)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["RNDR2"]}, "metabolites": {"trdox_c": 1.0, "h2o_c": 1.0, "dgdp_c": 1.0, "gdp_c": -1.0, "trdrd_c": -1.0}, "id": "RNDR2", 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"name": "L-threonine via sodium symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["THRt4pp"]}, "metabolites": {"na1_p": -1.0, "thr__L_p": -1.0, "thr__L_c": 1.0, "na1_c": 1.0}, "id": "THRt4pp", "gene_reaction_rule": "b3089"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "L-threonine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["THRtex"]}, "metabolites": {"thr__L_p": 1.0, "thr__L_e": -1.0}, "id": "THRtex", "gene_reaction_rule": "b0241 or b0929 or b1377 or b2215"}, {"subsystem": "Transport, Inner Membrane", "name": "Thymine transport out via proton antiport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["THYMt3pp"]}, "metabolites": {"h_p": -1.0, "h_c": 1.0, "thym_c": -1.0, "thym_p": 1.0}, "id": "THYMt3pp", "gene_reaction_rule": ""}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Thymine 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"Thymidine phosphorylase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["TMDPP"]}, "metabolites": {"2dr1p_c": 1.0, "pi_c": -1.0, "thym_c": 1.0, "thymd_c": -1.0}, "id": "TMDPP", "gene_reaction_rule": "b4382"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Thymidylate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TMDS"]}, "metabolites": {"dtmp_c": 1.0, "mlthf_c": -1.0, "dump_c": -1.0, "dhf_c": 1.0}, "id": "TMDS", "gene_reaction_rule": "b2827"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Thiamine kinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TMK"]}, "metabolites": {"thm_c": -1.0, "thmmp_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "atp_c": -1.0}, "id": "TMK", "gene_reaction_rule": "b1106"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Thiamine-phosphate kinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": 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"dpcoa_c": -1.0, "ade_c": 1.0, "atp_c": -1.0}, "id": "TPRDCOAS", "gene_reaction_rule": "b0613"}, {"subsystem": "Oxidative Phosphorylation", "name": "Thioredoxin reductase (NADPH)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TRDR"]}, "metabolites": {"trdox_c": -1.0, "nadp_c": 1.0, "nadph_c": -1.0, "trdrd_c": 1.0, "h_c": -1.0}, "id": "TRDR", "gene_reaction_rule": "(b3781 and b0888) or (b0888 and b2582)"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Trehalose-6-phosphate hydrolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TRE6PH"]}, "metabolites": {"tre6p_c": -1.0, "glc__D_c": 1.0, "g6p_c": 1.0, "h2o_c": -1.0}, "id": "TRE6PH", "gene_reaction_rule": "b4239"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Trehalose-phosphatase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TRE6PP"]}, "metabolites": {"tre6p_c": -1.0, "tre_c": 1.0, "h2o_c": -1.0, "pi_c": 1.0}, "id": "TRE6PP", 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"b0480"}, {"subsystem": "Alternate Carbon Metabolism", "name": "UDPglucose--hexose-1-phosphate uridylyltransferase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["UGLT"]}, "metabolites": {"udpgal_c": 1.0, "udpg_c": -1.0, "gal1p_c": -1.0, "g1p_c": 1.0}, "id": "UGLT", "gene_reaction_rule": "b0758"}, {"subsystem": "Nitrogen Metabolism", "name": "Ureidoglycolate hydrolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["UGLYCH"]}, "metabolites": {"urdglyc_c": -1.0, "h2o_c": -1.0, "glx_c": 1.0, "h_c": -2.0, "co2_c": 1.0, "nh4_c": 2.0}, "id": "UGLYCH", "gene_reaction_rule": "b0505"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine synthetase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["UGMDDS"]}, "metabolites": {"atp_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "ugmda_c": 1.0, "pi_c": 1.0, "alaala_c": -1.0, "ugmd_c": -1.0}, "id": "UGMDDS", "gene_reaction_rule": "b0086"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "UDP-3-O-acetylglucosamine deacetylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["UHGADA"]}, "metabolites": {"u3aga_c": -1.0, "u3hga_c": 1.0, "ac_c": 1.0, "h2o_c": -1.0}, "id": "UHGADA", "gene_reaction_rule": "b0096"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "UDP-L-Ara4N formyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ULA4NFT"]}, "metabolites": {"udpLa4fn_c": 1.0, "h_c": 1.0, "udpLa4n_c": -1.0, "10fthf_c": -1.0, "thf_c": 1.0}, "id": "ULA4NFT", "gene_reaction_rule": "b2255"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "Transport (cytoplasm to periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ULA4Ntppi"]}, "metabolites": {"uLa4n_p": 1.0, "uLa4n_c": -1.0}, "id": "ULA4Ntppi", "gene_reaction_rule": "b4544 and b2258"}, {"subsystem": "Murein Recycling", "name": "UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["UM3PL"]}, "metabolites": {"LalaDgluMdap_c": -1.0, "atp_c": -1.0, "uamr_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "ugmd_c": 1.0}, "id": "UM3PL", "gene_reaction_rule": "b4233"}, {"subsystem": "Murein Recycling", "name": "UDP-N-acetylmuramoyl-L-alanyl-D-gamma-glutamyl-meso-2,6-diaminopimelate-D-alanine L,D-carboxypeptidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["UM4PCP"]}, "metabolites": {"h2o_c": -1.0, "ala__D_c": 1.0, "um4p_c": -1.0, "ugmd_c": 1.0}, "id": "UM4PCP", "gene_reaction_rule": "b1192"}, {"subsystem": "Murein Recycling", "name": "UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate-D-alanine ligase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["UM4PL"]}, "metabolites": {"LalaDgluMdapDala_c": -1.0, "atp_c": -1.0, "uamr_c": -1.0, "um4p_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0}, "id": "UM4PL", "gene_reaction_rule": "b4233"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "UMP kinase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["UMPK"]}, "metabolites": {"ump_c": -1.0, "udp_c": 1.0, "atp_c": -1.0, "adp_c": 1.0}, "id": "UMPK", "gene_reaction_rule": "b0910 or b0171"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "UMP transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["UMPtex"]}, "metabolites": {"ump_p": 1.0, "ump_e": -1.0}, "id": "UMPtex", "gene_reaction_rule": "b0929 or b1377 or b2215 or b0241"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "Undecaprenyl phosphate-L-Ara4FN formylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["UPLA4FNF"]}, "metabolites": {"h2o_c": -1.0, "uLa4fn_c": -1.0, "for_c": 1.0, "uLa4n_c": 1.0}, "id": "UPLA4FNF", "gene_reaction_rule": "b2256"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "Undecaprenyl phosphate-L-Ara4FN transferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["UPLA4FNT"]}, "metabolites": {"udpLa4fn_c": -1.0, "udp_c": 1.0, "uLa4fn_c": 1.0, "udcpp_c": -1.0}, "id": "UPLA4FNT", "gene_reaction_rule": "b2254"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Uroporphyrinogen methyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["UPP3MT"]}, "metabolites": {"amet_c": -2.0, "dscl_c": 1.0, "ahcys_c": 2.0, "h_c": 1.0, "uppg3_c": -1.0}, "id": "UPP3MT", "gene_reaction_rule": "b3803 or b3368"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Uroporphyrinogen-III synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["UPP3S"]}, "metabolites": {"h2o_c": 1.0, "hmbil_c": -1.0, "uppg3_c": 1.0}, "id": "UPP3S", "gene_reaction_rule": "b3804"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Uroporphyrinogen decarboxylase (uroporphyrinogen III)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["UPPDC1"]}, "metabolites": {"co2_c": 4.0, "h_c": -4.0, "uppg3_c": -1.0, "cpppg3_c": 1.0}, "id": "UPPDC1", "gene_reaction_rule": "b3997"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Uracil phosphoribosyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["UPPRT"]}, "metabolites": {"ura_c": -1.0, "ppi_c": 1.0, "prpp_c": -1.0, "ump_c": 1.0}, "id": "UPPRT", "gene_reaction_rule": "b2498"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Peroxyureidoacrylate hydrolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["URACPAH"]}, "metabolites": {"h_c": 1.0, "h2o_c": -1.0, "poaac_c": 1.0, "uracp_c": -1.0, "cbm_c": 1.0}, "id": "URACPAH", "gene_reaction_rule": "b1011"}, {"subsystem": "Transport, Inner Membrane", "name": "Uracil transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["URAt2pp", "URAt2rpp"]}, "metabolites": {"ura_c": 1.0, "ura_p": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "URAt2pp_copy1", "gene_reaction_rule": "b2497"}, {"subsystem": "Transport, Inner Membrane", "name": "Uracil transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["URAt2pp", "URAt2rpp"]}, "metabolites": {"ura_c": 1.0, "ura_p": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "URAt2pp_copy2", "gene_reaction_rule": "b1006"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Uracil transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["URAtex"]}, "metabolites": {"ura_p": 1.0, "ura_e": -1.0}, "id": "URAtex", "gene_reaction_rule": "b0241 or b0929 or b1377 or b2215"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Ureidoglycolate dehydrogenase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["URDGLYCD"]}, "metabolites": {"urdglyc_c": -1.0, "nadh_c": 1.0, "oxur_c": 1.0, "h_c": 1.0, "nad_c": -1.0}, "id": "URDGLYCD", "gene_reaction_rule": "b0517"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Urea transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["UREAtex"]}, "metabolites": {"urea_p": 1.0, "urea_e": -1.0}, "id": "UREAtex", "gene_reaction_rule": "b0241 or b0929 or b1377 or b2215"}, {"subsystem": "Transport, Inner Membrane", "name": "Urea transport via facilitate diffusion (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["UREAtpp"]}, "metabolites": {"urea_p": -1.0, "urea_c": 1.0}, "id": "UREAtpp", "gene_reaction_rule": "b3927"}, {"subsystem": "Unassigned", "name": "Uricase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["URIC"]}, "metabolites": {"o2_c": -1.0, "h2o_c": -2.0, "urate_c": -1.0, "h2o2_c": 1.0, "co2_c": 1.0, "alltn_c": 1.0}, "id": "URIC", "gene_reaction_rule": ""}, {"subsystem": "Alternate Carbon Metabolism", "name": "Uridine hydrolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["URIH"]}, "metabolites": {"uri_c": -1.0, "h2o_c": -1.0, "rib__D_c": 1.0, "ura_c": 1.0}, "id": "URIH", "gene_reaction_rule": "b2162 or b0651 or b0030"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Uridine kinase (GTP:Uridine)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["URIK2"]}, "metabolites": {"ump_c": 1.0, "uri_c": -1.0, "gtp_c": -1.0, "h_c": 1.0, "gdp_c": 1.0}, "id": "URIK2", "gene_reaction_rule": "b2066"}, {"subsystem": "Transport, Inner Membrane", "name": "Uridine transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["URIt2pp", "URIt2rpp"]}, "metabolites": {"uri_c": 1.0, "uri_p": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "URIt2pp_copy1", "gene_reaction_rule": "b2393 or b2964"}, {"subsystem": "Transport, Inner Membrane", "name": "Uridine transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["URIt2pp", "URIt2rpp"]}, "metabolites": {"uri_c": 1.0, "uri_p": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "URIt2pp_copy2", "gene_reaction_rule": "b2406"}, {"subsystem": "Transport, Outer Membrane", "name": "Uridine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["URItex"]}, "metabolites": {"uri_p": 1.0, "uri_e": -1.0}, "id": "URItex", "gene_reaction_rule": "b0411"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "UDP-sugar hydrolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["USHD"]}, "metabolites": {"u23ga_c": -1.0, "h2o_c": -1.0, "h_c": 2.0, "lipidX_c": 1.0, "ump_c": 1.0}, "id": "USHD", "gene_reaction_rule": "b0524"}, {"subsystem": "Valine, Leucine, and Isoleucine Metabolism", "name": "Valine transaminase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["VALTA"]}, "metabolites": {"akg_c": -1.0, "glu__L_c": 1.0, "val__L_c": -1.0, "3mob_c": 1.0}, "id": "VALTA", "gene_reaction_rule": "b3770"}, {"subsystem": "tRNA Charging", "name": "Valyl-tRNA synthetase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["VALTRS"]}, "metabolites": {"valtrna_c": 1.0, "atp_c": -1.0, "ppi_c": 1.0, "amp_c": 1.0, "trnaval_c": -1.0, "val__L_c": -1.0}, "id": "VALTRS", "gene_reaction_rule": "b4258"}, {"subsystem": "Transport, Inner Membrane", "name": "L-valine transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["VALabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "val__L_p": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "val__L_c": 1.0}, "id": "VALabcpp", "gene_reaction_rule": "b3454 and b3455 and b3457 and b3460 and b3456"}, {"subsystem": "Transport, Inner Membrane", "name": "L-valine reversible transport via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["VALt2rpp"]}, "metabolites": {"val__L_p": -1.0, "h_c": 1.0, "h_p": -1.0, "val__L_c": 1.0}, "id": "VALt2rpp", "gene_reaction_rule": "b0401 or (b2683 and b2682)"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "L-valine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["VALtex"]}, "metabolites": {"val__L_e": -1.0, "val__L_p": 1.0}, "id": "VALtex", "gene_reaction_rule": "b0241 or b0929 or b1377 or b2215"}, {"subsystem": "Valine, Leucine, and Isoleucine 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(periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["XANtpp"]}, "metabolites": {"xan_p": -1.0, "xan_c": 1.0}, "id": "XANtpp", "gene_reaction_rule": ""}, {"subsystem": "Transport, Outer Membrane Porin", "name": "XMP transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["XMPtex"]}, "metabolites": {"xmp_p": 1.0, "xmp_e": -1.0}, "id": "XMPtex", "gene_reaction_rule": "b0241 or b0929 or b1377 or b2215"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Xanthine phosphoribosyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["XPPT"]}, "metabolites": {"xmp_c": 1.0, "ppi_c": 1.0, "prpp_c": -1.0, "xan_c": -1.0}, "id": "XPPT", "gene_reaction_rule": "b0238"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Xanthosine hydrolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["XTSNH"]}, "metabolites": 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{"original_bigg_ids": ["2ddglcn_c"]}, "charge": -1, "formula": "C6H9O6", "compartment": "c", "id": "2ddglcn_c"}, {"name": "2-Dehydro-3-deoxy-D-galactonate", "notes": {"original_bigg_ids": ["2dh3dgal_c"]}, "charge": -1, "formula": "C6H9O6", "compartment": "c", "id": "2dh3dgal_c"}, {"name": "2-Dehydro-3-deoxy-D-galactonate 6-phosphate", "notes": {"original_bigg_ids": ["2dh3dgal6p_c"]}, "charge": -3, "formula": "C6H8O9P", "compartment": "c", "id": "2dh3dgal6p_c"}, {"name": "2-Dehydro-L-gulonate", "notes": {"original_bigg_ids": ["2dhguln_c"]}, "charge": -1, "formula": "C6H9O7", "compartment": "c", "id": "2dhguln_c"}, {"name": "2-Dehydropantoate", "notes": {"original_bigg_ids": ["2dhp_c"]}, "charge": -1, "formula": "C6H9O4", "compartment": "c", "id": "2dhp_c"}, {"name": "2-Demethylmenaquinone 8", "notes": {"original_bigg_ids": ["2dmmq8_c"]}, "charge": 0, "formula": "C50H70O2", "compartment": "c", "id": "2dmmq8_c"}, {"name": "2-Demethylmenaquinol 8", "notes": {"original_bigg_ids": ["2dmmql8_c"]}, "charge": 0, "formula": "C50H72O2", "compartment": "c", "id": "2dmmql8_c"}, {"name": "2-Deoxy-D-ribose 1-phosphate", "notes": {"original_bigg_ids": ["2dr1p_c"]}, "charge": -2, "formula": "C5H9O7P", "compartment": "c", "id": "2dr1p_c"}, {"name": "2-Deoxy-D-ribose 5-phosphate", "notes": {"original_bigg_ids": ["2dr5p_c"]}, "charge": -2, "formula": "C5H9O7P", "compartment": "c", "id": "2dr5p_c"}, {"name": "[2Fe-1S] desulfurated iron-sulfur cluster", "notes": {"original_bigg_ids": ["2fe1s_c"]}, "charge": 2, "formula": "SFe2", "compartment": "c", "id": "2fe1s_c"}, {"name": "[2Fe-2S] iron-sulfur cluster", "notes": {"original_bigg_ids": ["2fe2s_c"]}, "charge": 2, "formula": "S2Fe2", "compartment": "c", "id": "2fe2s_c"}, {"name": "2-Hydroxy-3-oxopropanoate", "notes": {"original_bigg_ids": ["2h3oppan_c"]}, "charge": -1, "formula": "C3H3O4", "compartment": "c", "id": "2h3oppan_c"}, {"name": "2-hexadec-9-enoyl-sn-glycerol 3-phosphate", "notes": {"original_bigg_ids": ["2hdec9eg3p_c"]}, "charge": -1, "formula": "C19H36O7P1", "compartment": "c", "id": "2hdec9eg3p_c"}, {"name": "2-hexadecanoyl-sn-glycerol 3-phosphate", "notes": {"original_bigg_ids": ["2hdecg3p_c"]}, "charge": -1, "formula": "C19H38O7P1", "compartment": "c", "id": "2hdecg3p_c"}, {"name": "2-Isopropylmaleate", "notes": {"original_bigg_ids": ["2ippm_c"]}, "charge": -2, "formula": "C7H8O4", "compartment": "c", "id": "2ippm_c"}, {"name": "2-Methyl-4-amino-5-hydroxymethylpyrimidine diphosphate", "notes": {"original_bigg_ids": ["2mahmp_c"]}, "charge": -3, "formula": "C6H8N3O7P2", "compartment": "c", "id": "2mahmp_c"}, {"name": "Cis-2-Methylaconitate", "notes": {"original_bigg_ids": ["2mcacn_c"]}, "charge": -3, "formula": "C7H5O6", "compartment": "c", "id": "2mcacn_c"}, {"name": "2-Methylcitrate", "notes": {"original_bigg_ids": ["2mcit_c"]}, "charge": -3, "formula": "C7H7O7", "compartment": "c", "id": "2mcit_c"}, {"name": "2-C-methyl-D-erythritol 4-phosphate", "notes": {"original_bigg_ids": ["2me4p_c"]}, "charge": -2, "formula": "C5H11O7P", "compartment": "c", "id": "2me4p_c"}, {"name": "2-C-methyl-D-erythritol 2,4-cyclodiphosphate", "notes": {"original_bigg_ids": ["2mecdp_c"]}, "charge": -2, "formula": "C5H10O9P2", "compartment": "c", "id": "2mecdp_c"}, {"name": "2-Oxobutanoate", "notes": {"original_bigg_ids": ["2obut_c"]}, "charge": -1, "formula": "C4H5O3", "compartment": "c", "id": "2obut_c"}, {"name": "2-octadec-11-enoyl-sn-glycerol 3-phosphate", "notes": {"original_bigg_ids": ["2odec11eg3p_c"]}, "charge": -1, "formula": "C21H40O7P1", "compartment": "c", "id": "2odec11eg3p_c"}, {"name": "2-octadecanoyl-sn-glycerol 3-phosphate", "notes": {"original_bigg_ids": ["2odecg3p_c"]}, "charge": -1, "formula": "C21H42O7P1", "compartment": "c", "id": "2odecg3p_c"}, {"name": "2-Octaprenyl-6-hydroxyphenol", "notes": {"original_bigg_ids": ["2ohph_c"]}, "charge": 0, "formula": "C46H70O2", "compartment": "c", "id": "2ohph_c"}, {"name": "2-Octaprenyl-6-methoxy-1,4-benzoquinol", "notes": {"original_bigg_ids": ["2ombzl_c"]}, "charge": 0, "formula": "C47H72O3", "compartment": "c", "id": "2ombzl_c"}, {"name": "2-Octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol", "notes": {"original_bigg_ids": ["2omhmbl_c"]}, "charge": 0, "formula": "C48H74O4", "compartment": "c", "id": "2omhmbl_c"}, {"name": "2-Octaprenyl-3-methyl-6-methoxy- 1,4-benzoquinol", "notes": {"original_bigg_ids": ["2ommbl_c"]}, "charge": 0, "formula": "C48H74O3", "compartment": "c", "id": "2ommbl_c"}, {"name": "2-Octaprenyl-6-methoxyphenol", "notes": {"original_bigg_ids": ["2omph_c"]}, "charge": 0, "formula": "C47H72O2", "compartment": "c", "id": "2omph_c"}, {"name": "2-Octaprenylphenol", "notes": {"original_bigg_ids": ["2oph_c"]}, "charge": 0, "formula": "C46H70O", "compartment": "c", "id": "2oph_c"}, {"name": "2-oxepin-2(3H)-ylideneacetyl-CoA", "notes": {"original_bigg_ids": ["2oxpaccoa_c"]}, "charge": -4, "formula": "C29H38N7O18P3S", "compartment": "c", "id": "2oxpaccoa_c"}, {"name": "2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol", "notes": {"original_bigg_ids": ["2p4c2me_c"]}, "charge": -4, "formula": "C14H22N3O17P3", "compartment": "c", "id": "2p4c2me_c"}, {"name": "D-Glycerate 2-phosphate", "notes": {"original_bigg_ids": ["2pg_c"]}, "charge": -3, "formula": "C3H4O7P", "compartment": "c", "id": "2pg_c"}, {"name": "2-Phosphoglycolate", "notes": {"original_bigg_ids": ["2pglyc_c"]}, "charge": -3, "formula": "C2H2O6P", "compartment": "c", "id": "2pglyc_c"}, {"name": "2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate", "notes": {"original_bigg_ids": ["2sephchc_c"]}, "charge": -3, "formula": "C14H13O9", "compartment": "c", "id": "2sephchc_c"}, {"name": "2-Succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate", "notes": {"original_bigg_ids": ["2shchc_c"]}, "charge": -2, "formula": "C11H10O6", "compartment": "c", "id": "2shchc_c"}, {"name": "2-tetradec-7-enoyl-sn-glycerol 3-phosphate", "notes": {"original_bigg_ids": ["2tdec7eg3p_c"]}, "charge": -1, "formula": "C17H32O7P1", "compartment": "c", "id": "2tdec7eg3p_c"}, {"name": "2-tetradecanoyl-sn-glycerol 3-phosphate", "notes": {"original_bigg_ids": ["2tdecg3p_c"]}, "charge": -1, "formula": "C17H34O7P1", "compartment": "c", "id": "2tdecg3p_c"}, {"name": "2'-(5''-triphosphoribosyl)-3'-dephospho-CoA", "notes": {"original_bigg_ids": ["2tpr3dpcoa_c"]}, "charge": -6, "formula": "C26H40N7O26P5S", "compartment": "c", "id": "2tpr3dpcoa_c"}, {"name": "3-(4-Hydroxyphenyl)pyruvate", "notes": {"original_bigg_ids": ["34hpp_c"]}, "charge": -1, "formula": "C9H7O4", "compartment": "c", "id": "34hpp_c"}, {"name": "3',5'-Cyclic GMP", "notes": {"original_bigg_ids": ["35cgmp_c"]}, "charge": -1, "formula": "C10H11N5O7P", "compartment": "c", "id": "35cgmp_c"}, {"name": "3-Aminoacrylate", "notes": {"original_bigg_ids": ["3amac_c"]}, "charge": -1, "formula": "C3H4NO2", "compartment": "c", "id": "3amac_c"}, {"name": "3-Carboxy-2-hydroxy-4-methylpentanoate", "notes": {"original_bigg_ids": ["3c2hmp_c"]}, "charge": -2, "formula": "C7H10O5", "compartment": "c", "id": "3c2hmp_c"}, {"name": "3-Carboxy-3-hydroxy-4-methylpentanoate", "notes": {"original_bigg_ids": ["3c3hmp_c"]}, "charge": -2, "formula": "C7H10O5", "compartment": "c", "id": "3c3hmp_c"}, {"name": "3-Carboxy-4-methyl-2-oxopentanoate", "notes": {"original_bigg_ids": ["3c4mop_c"]}, "charge": -2, "formula": "C7H8O5", "compartment": "c", "id": "3c4mop_c"}, {"name": "3-Dehydro-L-gulonate", "notes": {"original_bigg_ids": ["3dhguln_c"]}, "charge": -1, "formula": "C6H9O7", "compartment": "c", "id": "3dhguln_c"}, {"name": "3-keto-L-gulonate-6-phosphate", "notes": {"original_bigg_ids": ["3dhgulnp_c"]}, "charge": -3, "formula": "C6H8O10P", "compartment": "c", "id": "3dhgulnp_c"}, {"name": "3-Dehydroquinate", "notes": {"original_bigg_ids": ["3dhq_c"]}, "charge": -1, "formula": "C7H9O6", "compartment": "c", "id": "3dhq_c"}, {"name": "3-Dehydroshikimate", "notes": {"original_bigg_ids": ["3dhsk_c"]}, "charge": -1, "formula": "C7H7O5", "compartment": "c", "id": "3dhsk_c"}, {"name": "[3Fe-4S] damaged iron-sulfur cluster", "notes": {"original_bigg_ids": ["3fe4s_c"]}, "charge": 0, "formula": "S4Fe3", "compartment": "c", "id": "3fe4s_c"}, {"name": "(3R)-3-Hydroxyacyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3haACP_c"]}, "charge": -1, "formula": "C15H27N2O9PRS", "compartment": "c", "id": "3haACP_c"}, {"name": "(3S)-3-Hydroxyadipyl-CoA", "notes": {"original_bigg_ids": ["3hadpcoa_c"]}, "charge": -5, "formula": "C27H39N7O20P3S", "compartment": "c", "id": "3hadpcoa_c"}, {"name": "(S)-3-Hydroxybutanoyl-CoA", "notes": {"original_bigg_ids": ["3hbcoa_c"]}, "charge": -4, "formula": "C25H38N7O18P3S", "compartment": "c", "id": "3hbcoa_c"}, {"name": "(R)-3-hydroxy-cis-dodec-5-enoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3hcddec5eACP_c"]}, "charge": -1, "formula": "C23H41N2O9PRS", "compartment": "c", "id": "3hcddec5eACP_c"}, {"name": "3-hydroxycinnamic acid", "notes": {"original_bigg_ids": ["3hcinnm_c"]}, "charge": -1, "formula": "C9H7O3", "compartment": "c", "id": "3hcinnm_c"}, {"name": "(R)-3-hydroxy-cis-myristol-7-eoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3hcmrs7eACP_c"]}, "charge": -1, "formula": "C25H45N2O9PRS", "compartment": "c", "id": "3hcmrs7eACP_c"}, {"name": "(R)-3-hydroxy-cis-palm-9-eoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3hcpalm9eACP_c"]}, "charge": -1, "formula": "C27H49N2O9PRS", "compartment": "c", "id": "3hcpalm9eACP_c"}, {"name": "(R)-3-hydroxy-cis-vacc-11-enoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3hcvac11eACP_c"]}, "charge": -1, "formula": "C29H53N2O9PRS", "compartment": "c", "id": "3hcvac11eACP_c"}, {"name": "(S)-3-Hydroxydecanoyl-CoA", "notes": {"original_bigg_ids": ["3hdcoa_c"]}, "charge": -4, "formula": "C31H50N7O18P3S", "compartment": "c", "id": "3hdcoa_c"}, {"name": "(S)-3-Hydroxydodecanoyl-CoA", "notes": {"original_bigg_ids": ["3hddcoa_c"]}, "charge": -4, "formula": "C33H54N7O18P3S", "compartment": "c", "id": "3hddcoa_c"}, {"name": "(R)-3-Hydroxydodecanoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3hddecACP_c"]}, "charge": -1, "formula": "C23H43N2O9PRS", "compartment": "c", "id": "3hddecACP_c"}, {"name": "(R)-3-Hydroxydecanoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3hdecACP_c"]}, "charge": -1, "formula": "C21H39N2O9PRS", "compartment": "c", "id": "3hdecACP_c"}, {"name": "(S)-3-Hydroxyhexanoyl-CoA", "notes": {"original_bigg_ids": ["3hhcoa_c"]}, "charge": -4, "formula": "C27H42N7O18P3S", "compartment": "c", "id": "3hhcoa_c"}, {"name": "(S)-3-Hydroxyhexadecanoyl-CoA", "notes": {"original_bigg_ids": ["3hhdcoa_c"]}, "charge": -4, "formula": "C37H62N7O18P3S", "compartment": "c", "id": "3hhdcoa_c"}, {"name": "(R)-3-Hydroxyhexanoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3hhexACP_c"]}, "charge": -1, "formula": "C17H31N2O9PRS", "compartment": "c", "id": "3hhexACP_c"}, {"name": "(R)-3-Hydroxytetradecanoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3hmrsACP_c"]}, "charge": -1, "formula": "C25H47N2O9PRS", "compartment": "c", "id": "3hmrsACP_c"}, {"name": "(S)-3-Hydroxyoctanoyl-CoA", "notes": {"original_bigg_ids": ["3hocoa_c"]}, "charge": -4, "formula": "C29H46N7O18P3S", "compartment": "c", "id": "3hocoa_c"}, {"name": "(R)-3-Hydroxyoctanoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3hoctACP_c"]}, "charge": -1, "formula": "C19H35N2O9PRS", "compartment": "c", "id": "3hoctACP_c"}, {"name": "(R)-3-Hydroxyoctadecanoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3hoctaACP_c"]}, "charge": -1, "formula": "C29H55N2O9PRS", "compartment": "c", "id": "3hoctaACP_c"}, {"name": "(S)-3-Hydroxyoctadecanoyl-CoA", "notes": {"original_bigg_ids": ["3hodcoa_c"]}, "charge": -4, "formula": "C39H66N7O18P3S", "compartment": "c", "id": "3hodcoa_c"}, {"name": "R-3-hydroxypalmitoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3hpalmACP_c"]}, "charge": -1, "formula": "C27H51N2O9PRS", "compartment": "c", "id": "3hpalmACP_c"}, {"name": "3-Hydroxypropanoate", "notes": {"original_bigg_ids": ["3hpp_c"]}, "charge": -1, "formula": "C3H5O3", "compartment": "c", "id": "3hpp_c"}, {"name": "3-(3-hydroxy-phenyl)propionate", "notes": {"original_bigg_ids": ["3hpppn_c"]}, "charge": -1, "formula": "C9H9O3", "compartment": "c", "id": "3hpppn_c"}, {"name": "(S)-3-Hydroxytetradecanoyl-CoA", "notes": {"original_bigg_ids": ["3htdcoa_c"]}, "charge": -4, "formula": "C35H58N7O18P3S", "compartment": "c", "id": "3htdcoa_c"}, {"name": "C'-(3-Indolyl)-glycerol 3-phosphate", "notes": {"original_bigg_ids": ["3ig3p_c"]}, "charge": -2, "formula": "C11H12NO6P", "compartment": "c", "id": "3ig3p_c"}, {"name": "3-Methyl-2-oxobutanoate", "notes": {"original_bigg_ids": ["3mob_c"]}, "charge": -1, "formula": "C5H7O3", "compartment": "c", "id": "3mob_c"}, {"name": "(S)-3-Methyl-2-oxopentanoate", "notes": {"original_bigg_ids": ["3mop_c"]}, "charge": -1, "formula": "C6H9O3", "compartment": "c", "id": "3mop_c"}, {"name": "3-oxo-cis-dodec-5-enoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3ocddec5eACP_c"]}, "charge": -1, "formula": "C23H39N2O9PRS", "compartment": "c", "id": "3ocddec5eACP_c"}, {"name": "3-oxo-cis-myristol-7-eoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3ocmrs7eACP_c"]}, "charge": -1, "formula": "C25H43N2O9PRS", "compartment": "c", "id": "3ocmrs7eACP_c"}, {"name": "3-oxo-cis-palm-9-eoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3ocpalm9eACP_c"]}, "charge": -1, "formula": "C27H47N2O9PRS", "compartment": "c", "id": "3ocpalm9eACP_c"}, {"name": "3-oxo-cis-vacc-11-enoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3ocvac11eACP_c"]}, "charge": -1, "formula": "C29H51N2O9PRS", "compartment": "c", "id": "3ocvac11eACP_c"}, {"name": "3-Oxodecanoyl-CoA", "notes": {"original_bigg_ids": ["3odcoa_c"]}, "charge": -4, "formula": "C31H48N7O18P3S", "compartment": "c", "id": "3odcoa_c"}, {"name": "3-Oxododecanoyl-CoA", "notes": {"original_bigg_ids": ["3oddcoa_c"]}, "charge": -4, "formula": "C33H52N7O18P3S", "compartment": "c", "id": "3oddcoa_c"}, {"name": "3-Oxododecanoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3oddecACP_c"]}, "charge": -1, "formula": "C23H41N2O9PRS", "compartment": "c", "id": "3oddecACP_c"}, {"name": "3-Oxodecanoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3odecACP_c"]}, "charge": -1, "formula": "C21H37N2O9PRS", "compartment": "c", "id": "3odecACP_c"}, {"name": "3-Oxohexanoyl-CoA", "notes": {"original_bigg_ids": ["3ohcoa_c"]}, "charge": -4, "formula": "C27H40N7O18P3S", "compartment": "c", "id": "3ohcoa_c"}, {"name": "3-Oxohexadecanoyl-CoA", "notes": {"original_bigg_ids": ["3ohdcoa_c"]}, "charge": -4, "formula": "C37H60N7O18P3S", "compartment": "c", "id": "3ohdcoa_c"}, {"name": "3-Oxohexanoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3ohexACP_c"]}, "charge": -1, "formula": "C17H29N2O9PRS", "compartment": "c", "id": "3ohexACP_c"}, {"name": "3-Oxotetradecanoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3omrsACP_c"]}, "charge": -1, "formula": "C25H45N2O9PRS", "compartment": "c", "id": "3omrsACP_c"}, {"name": "3-Oxooctanoyl-CoA", "notes": {"original_bigg_ids": ["3oocoa_c"]}, "charge": -4, "formula": "C29H44N7O18P3S", "compartment": "c", "id": "3oocoa_c"}, {"name": "3-Oxooctanoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3ooctACP_c"]}, "charge": -1, "formula": "C19H33N2O9PRS", "compartment": "c", "id": "3ooctACP_c"}, {"name": "3-Oxooctadecanoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3ooctdACP_c"]}, "charge": -1, "formula": "C29H53N2O9PRS", "compartment": "c", "id": "3ooctdACP_c"}, {"name": "3-Oxooctadecanoyl-CoA", "notes": {"original_bigg_ids": ["3oodcoa_c"]}, "charge": -4, "formula": "C39H64N7O18P3S", "compartment": "c", "id": "3oodcoa_c"}, {"name": "3-Oxohexadecanoyl-[acyl-carrier protein]", "notes": 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"compartment": "c", "id": "maltpt_c"}, {"name": "Maltotriose", "notes": {"original_bigg_ids": ["malttr_c"]}, "charge": 0, "formula": "C18H32O16", "compartment": "c", "id": "malttr_c"}, {"name": "Maltotetraose", "notes": {"original_bigg_ids": ["maltttr_c"]}, "charge": 0, "formula": "C24H42O21", "compartment": "c", "id": "maltttr_c"}, {"name": "D-Mannose", "notes": {"original_bigg_ids": ["man_c"]}, "charge": 0, "formula": "C6H12O6", "compartment": "c", "id": "man_c"}, {"name": "D-Mannose 1-phosphate", "notes": {"original_bigg_ids": ["man1p_c"]}, "charge": -2, "formula": "C6H11O9P", "compartment": "c", "id": "man1p_c"}, {"name": "D-Mannose 6-phosphate", "notes": {"original_bigg_ids": ["man6p_c"]}, "charge": -2, "formula": "C6H11O9P", "compartment": "c", "id": "man6p_c"}, {"name": "2(alpha-D-Mannosyl-6-phosphate)-D-glycerate", "notes": {"original_bigg_ids": ["man6pglyc_c"]}, "charge": -3, "formula": "C9H14O12P", "compartment": "c", "id": "man6pglyc_c"}, {"name": "D-Mannonate", "notes": 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"c", "id": "met__L_c"}, {"name": "5,10-Methenyltetrahydrofolate", "notes": {"original_bigg_ids": ["methf_c"]}, "charge": -1, "formula": "C20H20N7O6", "compartment": "c", "id": "methf_c"}, {"name": "L-methionine-R-sulfoxide", "notes": {"original_bigg_ids": ["metsox_DASH_R_DASH_L_c"]}, "charge": 0, "formula": "C5H11NO3S", "compartment": "c", "id": "metsox_R__L_c"}, {"name": "L-Methionine Sulfoxide", "notes": {"original_bigg_ids": ["metsox_DASH_S_DASH_L_c"]}, "charge": 0, "formula": "C5H11NO3S", "compartment": "c", "id": "metsox_S__L_c"}, {"name": "L-Methionyl-tRNA (Met)", "notes": {"original_bigg_ids": ["mettrna_c"]}, "charge": 1, "formula": "C5H10NOSR", "compartment": "c", "id": "mettrna_c"}, {"name": "Magnesium", "notes": {"original_bigg_ids": ["mg2_c"]}, "charge": 2, "formula": "Mg", "compartment": "c", "id": "mg2_c"}, {"name": "1D-myo-Inositol 1-phosphate", "notes": {"original_bigg_ids": ["mi1p_DASH_D_c"]}, "charge": -2, "formula": "C6H11O9P", "compartment": "c", "id": "mi1p__D_c"}, {"name": "Methylisocitrate", "notes": {"original_bigg_ids": ["micit_c"]}, "charge": -3, "formula": "C7H7O7", "compartment": "c", "id": "micit_c"}, {"name": "5,10-Methylenetetrahydrofolate", "notes": {"original_bigg_ids": ["mlthf_c"]}, "charge": -2, "formula": "C20H21N7O6", "compartment": "c", "id": "mlthf_c"}, {"name": "(S)-Methylmalonyl-CoA", "notes": {"original_bigg_ids": ["mmcoa_DASH_S_c"]}, "charge": -5, "formula": "C25H35N7O19P3S", "compartment": "c", "id": "mmcoa__S_c"}, {"name": "S-Methyl-L-methionine", "notes": {"original_bigg_ids": ["mmet_c"]}, "charge": 1, "formula": "C6H14NO2S", "compartment": "c", "id": "mmet_c"}, {"name": "Mn2+", "notes": {"original_bigg_ids": ["mn2_c"]}, "charge": 2, "formula": "Mn", "compartment": "c", "id": "mn2_c"}, {"name": "D-Mannitol 1-phosphate", "notes": {"original_bigg_ids": ["mnl1p_c"]}, "charge": -2, "formula": "C6H13O9P", "compartment": "c", "id": "mnl1p_c"}, {"name": "MoaD Protein with bound AMP", "notes": {"original_bigg_ids": 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{"name": "Shikimate", "notes": {"original_bigg_ids": ["skm_e"]}, "charge": -1, "formula": "C7H9O5", "compartment": "e", "id": "skm_e"}, {"name": "Selenite", "notes": {"original_bigg_ids": ["slnt_e"]}, "charge": -2, "formula": "O3Se", "compartment": "e", "id": "slnt_e"}, {"name": "Sulfur dioxide", "notes": {"original_bigg_ids": ["so2_e"]}, "charge": 0, "formula": "O2S", "compartment": "e", "id": "so2_e"}, {"name": "Sulfite", "notes": {"original_bigg_ids": ["so3_e"]}, "charge": -2, "formula": "O3S", "compartment": "e", "id": "so3_e"}, {"name": "Sulfate", "notes": {"original_bigg_ids": ["so4_e"]}, "charge": -2, "formula": "O4S", "compartment": "e", "id": "so4_e"}, {"name": "Spermidine", "notes": {"original_bigg_ids": ["spmd_e"]}, "charge": 3, "formula": "C7H22N3", "compartment": "e", "id": "spmd_e"}, {"name": "Succinate", "notes": {"original_bigg_ids": ["succ_e"]}, "charge": -2, "formula": "C4H4O4", "compartment": "e", "id": "succ_e"}, {"name": "Sulfoacetate", "notes": {"original_bigg_ids": ["sulfac_e"]}, "charge": -2, "formula": "C2H2O5S", "compartment": "e", "id": "sulfac_e"}, {"name": "D-tartrate", "notes": {"original_bigg_ids": ["tartr_DASH_D_e"]}, "charge": -2, "formula": "C4H4O6", "compartment": "e", "id": "tartr__D_e"}, {"name": "L-tartrate", "notes": {"original_bigg_ids": ["tartr_DASH_L_e"]}, "charge": -2, "formula": "C4H4O6", "compartment": "e", "id": "tartr__L_e"}, {"name": "Taurine", "notes": {"original_bigg_ids": ["taur_e"]}, "charge": 0, "formula": "C2H7NO3S", "compartment": "e", "id": "taur_e"}, {"name": "Thiocyanate", "notes": {"original_bigg_ids": ["tcynt_e"]}, "charge": -1, "formula": "CNS", "compartment": "e", "id": "tcynt_e"}, {"name": "Thiamin", "notes": {"original_bigg_ids": ["thm_e"]}, "charge": 1, "formula": "C12H17N4OS", "compartment": "e", "id": "thm_e"}, {"name": "L-Threonine", "notes": {"original_bigg_ids": ["thr_DASH_L_e"]}, "charge": 0, "formula": "C4H9NO3", "compartment": "e", "id": "thr__L_e"}, {"name": "Thymine", "notes": {"original_bigg_ids": ["thym_e"]}, "charge": 0, "formula": "C5H6N2O2", "compartment": "e", "id": "thym_e"}, {"name": "Thymidine", "notes": {"original_bigg_ids": ["thymd_e"]}, "charge": 0, "formula": "C10H14N2O5", "compartment": "e", "id": "thymd_e"}, {"name": "Trimethylamine", "notes": {"original_bigg_ids": ["tma_e"]}, "charge": 1, "formula": "C3H10N", "compartment": "e", "id": "tma_e"}, {"name": "Trimethylamine N-oxide", "notes": {"original_bigg_ids": ["tmao_e"]}, "charge": 0, "formula": "C3H9NO", "compartment": "e", "id": "tmao_e"}, {"name": "Trehalose", "notes": {"original_bigg_ids": ["tre_e"]}, "charge": 0, "formula": "C12H22O11", "compartment": "e", "id": "tre_e"}, {"name": "L-Tryptophan", "notes": {"original_bigg_ids": ["trp_DASH_L_e"]}, "charge": 0, "formula": "C11H12N2O2", "compartment": "e", "id": "trp__L_e"}, {"name": "Thiosulfate", "notes": {"original_bigg_ids": ["tsul_e"]}, "charge": -2, "formula": "O3S2", "compartment": "e", "id": "tsul_e"}, {"name": "Tetradecanoate (n-C14:0)", "notes": {"original_bigg_ids": ["ttdca_e"]}, "charge": -1, "formula": "C14H27O2", "compartment": "e", "id": "ttdca_e"}, {"name": "Tetradecenoate (n-C14:1)", "notes": {"original_bigg_ids": ["ttdcea_e"]}, "charge": -1, "formula": "C14H25O2", "compartment": "e", "id": "ttdcea_e"}, {"name": "Tungstate", "notes": {"original_bigg_ids": ["tungs_e"]}, "charge": -2, "formula": "O4W1", "compartment": "e", "id": "tungs_e"}, {"name": "L-Tyrosine", "notes": {"original_bigg_ids": ["tyr_DASH_L_e"]}, "charge": 0, "formula": "C9H11NO3", "compartment": "e", "id": "tyr__L_e"}, {"name": "UDP-N-acetyl-D-glucosamine", "notes": {"original_bigg_ids": ["uacgam_e"]}, "charge": -2, "formula": "C17H25N3O17P2", "compartment": "e", "id": "uacgam_e"}, {"name": "UDPglucose", "notes": {"original_bigg_ids": ["udpg_e"]}, "charge": -2, "formula": "C15H22N2O17P2", "compartment": "e", "id": "udpg_e"}, {"name": "UDPgalactose", "notes": {"original_bigg_ids": ["udpgal_e"]}, "charge": -2, "formula": "C15H22N2O17P2", "compartment": "e", "id": "udpgal_e"}, {"name": "UDP-D-glucuronate", "notes": {"original_bigg_ids": ["udpglcur_e"]}, "charge": -3, "formula": "C15H19N2O18P2", "compartment": "e", "id": "udpglcur_e"}, {"name": "UMP", "notes": {"original_bigg_ids": ["ump_e"]}, "charge": -2, "formula": "C9H11N2O9P", "compartment": "e", "id": "ump_e"}, {"name": "Uracil", "notes": {"original_bigg_ids": ["ura_e"]}, "charge": 0, "formula": "C4H4N2O2", "compartment": "e", "id": "ura_e"}, {"name": "Urea", "notes": {"original_bigg_ids": ["urea_e"]}, "charge": 0, "formula": "CH4N2O", "compartment": "e", "id": "urea_e"}, {"name": "Uridine", "notes": {"original_bigg_ids": ["uri_e"]}, "charge": 0, "formula": "C9H12N2O6", "compartment": "e", "id": "uri_e"}, {"name": "L-Valine", "notes": {"original_bigg_ids": ["val_DASH_L_e"]}, "charge": 0, "formula": "C5H11NO2", "compartment": "e", "id": "val__L_e"}, {"name": "Xanthine", "notes": {"original_bigg_ids": ["xan_e"]}, "charge": 0, "formula": "C5H4N4O2", "compartment": "e", "id": "xan_e"}, {"name": "Xanthosine 5'-phosphate", "notes": {"original_bigg_ids": ["xmp_e"]}, "charge": -2, "formula": "C10H11N4O9P", "compartment": "e", "id": "xmp_e"}, {"name": "Xanthosine", "notes": {"original_bigg_ids": ["xtsn_e"]}, "charge": 0, "formula": "C10H12N4O6", "compartment": "e", "id": "xtsn_e"}, {"name": "D-Xylose", "notes": {"original_bigg_ids": ["xyl_DASH_D_e"]}, "charge": 0, "formula": "C5H10O5", "compartment": "e", "id": "xyl__D_e"}, {"name": "L-Xylulose", "notes": {"original_bigg_ids": ["xylu_DASH_L_e"]}, "charge": 0, "formula": "C5H10O5", "compartment": "e", "id": "xylu__L_e"}, {"name": "Zinc", "notes": {"original_bigg_ids": ["zn2_e"]}, "charge": 2, "formula": "Zn", "compartment": "e", "id": "zn2_e"}, {"name": "2',3'-Cyclic AMP", "notes": {"original_bigg_ids": ["23camp_e"]}, "charge": -1, "formula": "C10H11N5O6P", "compartment": "e", "id": "23camp_e"}, {"name": "2',3'-Cyclic CMP", "notes": {"original_bigg_ids": ["23ccmp_e"]}, "charge": -1, "formula": "C9H11N3O7P", "compartment": "e", "id": "23ccmp_e"}, {"name": "2',3'-Cyclic GMP", "notes": {"original_bigg_ids": ["23cgmp_e"]}, "charge": -1, "formula": "C10H11N5O7P", "compartment": "e", "id": "23cgmp_e"}, {"name": "2',3'-Cyclic UMP", "notes": {"original_bigg_ids": ["23cump_e"]}, "charge": -1, "formula": "C9H10N2O8P", "compartment": "e", "id": "23cump_e"}, {"name": "3,4-Dihydroxyphenylacetaldehyde", "notes": {"original_bigg_ids": ["34dhpac_e"]}, "charge": 0, "formula": "C8H8O3", "compartment": "e", "id": "34dhpac_e"}, {"name": "3'-AMP", "notes": {"original_bigg_ids": ["3amp_e"]}, "charge": -2, "formula": "C10H12N5O7P", "compartment": "e", "id": "3amp_e"}, {"name": "3'-cmp", "notes": {"original_bigg_ids": ["3cmp_e"]}, "charge": -2, "formula": "C9H12N3O8P", "compartment": "e", "id": "3cmp_e"}, {"name": "3'-GMP", "notes": {"original_bigg_ids": ["3gmp_e"]}, "charge": -2, "formula": "C10H12N5O8P", "compartment": "e", "id": "3gmp_e"}, {"name": "3'-UMP", "notes": {"original_bigg_ids": ["3ump_e"]}, "charge": -2, "formula": "C9H11N2O9P", "compartment": "e", "id": "3ump_e"}, {"name": "4-Hydroxyphenylacetaldehyde", "notes": {"original_bigg_ids": ["4hoxpacd_e"]}, "charge": 0, "formula": "C8H8O2", "compartment": "e", "id": "4hoxpacd_e"}, {"name": "N-Acetyl-D-galactosamine", "notes": {"original_bigg_ids": ["acgal_e"]}, "charge": 0, "formula": "C8H15NO6", "compartment": "e", "id": "acgal_e"}, {"name": "N-Acetyl-D-galactosamine 1-phosphate", "notes": {"original_bigg_ids": ["acgal1p_e"]}, "charge": -2, "formula": "C8H14NO9P", "compartment": "e", "id": "acgal1p_e"}, {"name": "N-Acetylmuramate", "notes": {"original_bigg_ids": ["acmum_e"]}, "charge": -1, "formula": "C11H18NO8", "compartment": "e", "id": "acmum_e"}, {"name": "4-Amino-4-deoxy-L-arabinose modified core oligosaccharide lipid A", "notes": {"original_bigg_ids": ["acolipa_e"]}, "charge": -9, "formula": "C181H314N3O103P4", "compartment": "e", "id": "acolipa_e"}, {"name": "Arbutin", "notes": {"original_bigg_ids": ["arbt_e"]}, "charge": 0, "formula": "C12H16O7", "compartment": "e", "id": "arbt_e"}, {"name": "L-Ascorbate", "notes": {"original_bigg_ids": ["ascb_DASH_L_e"]}, "charge": 0, "formula": "C6H8O6", "compartment": "e", "id": "ascb__L_e"}, {"name": "N,N'-diacetylchitobiose", "notes": {"original_bigg_ids": ["chtbs_e"]}, "charge": 0, "formula": "C16H28N2O11", "compartment": "e", "id": "chtbs_e"}, {"name": "Chloramphenicol", "notes": {"original_bigg_ids": ["cm_e"]}, "charge": 0, "formula": "C11H12Cl2N2O5", "compartment": "e", "id": "cm_e"}, {"name": "Core oligosaccharide lipid A diphosphate", "notes": {"original_bigg_ids": ["colipap_e"]}, "charge": -12, "formula": "C176H303N2O103P5", "compartment": "e", "id": "colipap_e"}, {"name": "Dopamine", "notes": {"original_bigg_ids": ["dopa_e"]}, "charge": 1, "formula": "C8H12NO2", "compartment": "e", "id": "dopa_e"}, {"name": "Doxorubicin", "notes": {"original_bigg_ids": ["doxrbcn_e"]}, "charge": 0, "formula": "C27H29NO11", "compartment": "e", "id": "doxrbcn_e"}, {"name": "(enterobacterial common antigen)x4 core oligosaccharide lipid A", "notes": {"original_bigg_ids": ["eca4colipa_e"]}, "charge": -15, "formula": "C272H447N14O160P4", "compartment": "e", "id": "eca4colipa_e"}, {"name": "Phosphoethanolamine KDO(2)-lipid (A)", "notes": {"original_bigg_ids": ["enlipa_e"]}, "charge": -6, "formula": "C112H202N3O42P3", "compartment": "e", "id": "enlipa_e"}, {"name": "Fe(III)dicitrate", "notes": {"original_bigg_ids": ["fe3dcit_e"]}, "charge": -3, "formula": "C12H10FeO14", "compartment": "e", "id": "fe3dcit_e"}, {"name": "Fusidic acid", "notes": {"original_bigg_ids": ["fusa_e"]}, "charge": 0, "formula": "C31H48O5", "compartment": "e", "id": "fusa_e"}, {"name": "Beta D-Galactose", "notes": {"original_bigg_ids": ["gal_DASH_bD_e"]}, "charge": 0, "formula": "C6H12O6", "compartment": "e", "id": "gal_bD_e"}, {"name": "Galactitol", "notes": {"original_bigg_ids": ["galt_e"]}, "charge": 0, "formula": "C6H14O6", "compartment": "e", "id": "galt_e"}, {"name": "D-Glucosamine", "notes": {"original_bigg_ids": ["gam_e"]}, "charge": 1, "formula": "C6H14NO5", "compartment": "e", "id": "gam_e"}, {"name": "D-Glucuronate 1-phosphate", "notes": {"original_bigg_ids": ["glcur1p_e"]}, "charge": -3, "formula": "C6H8O10P", "compartment": "e", "id": "glcur1p_e"}, {"name": "Hepta-acylated core oligosaccharide lipid A (E. coli)", "notes": {"original_bigg_ids": ["hacolipa_e"]}, "charge": -11, "formula": "C192H333N2O101P4", "compartment": "e", "id": "hacolipa_e"}, {"name": "Hepta-acylated KDO(2)-lipid (A)", "notes": {"original_bigg_ids": ["halipa_e"]}, "charge": -6, "formula": "C126H226N2O40P2", "compartment": "e", "id": "halipa_e"}, {"name": "2(alpha-D-Mannosyl)-D-glycerate", "notes": {"original_bigg_ids": ["manglyc_e"]}, "charge": -1, "formula": "C9H15O9", "compartment": "e", "id": "manglyc_e"}, {"name": "Minocycline", "notes": {"original_bigg_ids": ["mincyc_e"]}, "charge": 0, "formula": "C23H27N3O7", "compartment": "e", "id": "mincyc_e"}, {"name": "Myo-Inositol hexakisphosphate", "notes": {"original_bigg_ids": ["minohp_e"]}, "charge": -12, "formula": "C6H6O24P6", "compartment": "e", "id": "minohp_e"}, {"name": "D-Mannitol", "notes": {"original_bigg_ids": ["mnl_e"]}, "charge": 0, "formula": "C6H14O6", "compartment": "e", "id": "mnl_e"}, {"name": "Novobiocin", "notes": {"original_bigg_ids": ["novbcn_e"]}, "charge": 0, "formula": "C31H36N2O11", "compartment": "e", "id": "novbcn_e"}, {"name": "(O16 antigen)x4 core oligosaccharide lipid A", "notes": {"original_bigg_ids": ["o16a4colipa_e"]}, "charge": -11, "formula": "C312H523N6O200P4", "compartment": "e", "id": "o16a4colipa_e"}, {"name": "Phenethylamine", "notes": {"original_bigg_ids": ["peamn_e"]}, "charge": 1, "formula": "C8H12N", "compartment": "e", "id": "peamn_e"}, {"name": "Phosphonate", "notes": {"original_bigg_ids": ["ppt_e"]}, "charge": -2, "formula": "HO3P", "compartment": "e", "id": "ppt_e"}, {"name": "Rifampin", "notes": {"original_bigg_ids": ["rfamp_e"]}, "charge": 0, "formula": "C43H58N4O12", "compartment": "e", "id": "rfamp_e"}, {"name": "D-Sorbitol", "notes": {"original_bigg_ids": ["sbt_DASH_D_e"]}, "charge": 0, "formula": "C6H14O6", "compartment": "e", "id": "sbt__D_e"}, {"name": "Sucrose", "notes": {"original_bigg_ids": ["sucr_e"]}, "charge": 0, "formula": "C12H22O11", "compartment": "e", "id": "sucr_e"}, {"name": "L-Threonine O-3-phosphate", "notes": {"original_bigg_ids": ["thrp_e"]}, "charge": -2, "formula": "C4H8NO6P", "compartment": "e", "id": "thrp_e"}, {"name": "Tetracycline", "notes": {"original_bigg_ids": ["ttrcyc_e"]}, "charge": 0, "formula": "C22H24N2O8", "compartment": "e", "id": "ttrcyc_e"}, {"name": "Tyramine", "notes": {"original_bigg_ids": ["tym_e"]}, "charge": 1, "formula": "C8H12NO", "compartment": "e", "id": "tym_e"}, {"name": "Phosphotyrosine", "notes": {"original_bigg_ids": ["tyrp_e"]}, "charge": -2, "formula": "C9H10NO6P", "compartment": "e", "id": "tyrp_e"}, {"name": "UDP-N-acetyl-D-galactosamine", "notes": {"original_bigg_ids": ["udpacgal_e"]}, "charge": -2, "formula": "C17H25N3O17P2", "compartment": "e", "id": "udpacgal_e"}, {"name": "1,2-Diacyl-sn-glycerol (didodecanoyl, n-C12:0)", "notes": {"original_bigg_ids": ["12dgr120_p"]}, "charge": 0, "formula": "C27H52O5", "compartment": "p", "id": "12dgr120_p"}, {"name": "1,2-Diacyl-sn-glycerol (ditetradecanoyl, n-C14:0)", "notes": {"original_bigg_ids": ["12dgr140_p"]}, "charge": 0, "formula": "C31H60O5", "compartment": "p", "id": "12dgr140_p"}, {"name": "1,2-Diacyl-sn-glycerol (ditetradec-7-enoyl, n-C14:1)", "notes": {"original_bigg_ids": ["12dgr141_p"]}, "charge": 0, "formula": "C31H56O5", "compartment": "p", "id": "12dgr141_p"}, {"name": "1,2-Diacyl-sn-glycerol (dihexadecanoyl, n-C16:0)", "notes": {"original_bigg_ids": ["12dgr160_p"]}, "charge": 0, "formula": "C35H68O5", "compartment": "p", "id": "12dgr160_p"}, {"name": "1,2-Diacyl-sn-glycerol (dihexadec-9-enoyl, n-C16:1)", "notes": 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"2',3'-Cyclic CMP", "notes": {"original_bigg_ids": ["23ccmp_p"]}, "charge": -1, "formula": "C9H11N3O7P", "compartment": "p", "id": "23ccmp_p"}, {"name": "2',3'-Cyclic GMP", "notes": {"original_bigg_ids": ["23cgmp_p"]}, "charge": -1, "formula": "C10H11N5O7P", "compartment": "p", "id": "23cgmp_p"}, {"name": "2',3'-Cyclic UMP", "notes": {"original_bigg_ids": ["23cump_p"]}, "charge": -1, "formula": "C9H10N2O8P", "compartment": "p", "id": "23cump_p"}, {"name": "3,4-Dihydroxyphenylacetaldehyde", "notes": {"original_bigg_ids": ["34dhpac_p"]}, "charge": 0, "formula": "C8H8O3", "compartment": "p", "id": "34dhpac_p"}, {"name": "3'-AMP", "notes": {"original_bigg_ids": ["3amp_p"]}, "charge": -2, "formula": "C10H12N5O7P", "compartment": "p", "id": "3amp_p"}, {"name": "3'-cmp", "notes": {"original_bigg_ids": ["3cmp_p"]}, "charge": -2, "formula": "C9H12N3O8P", "compartment": "p", "id": "3cmp_p"}, {"name": "3'-GMP", "notes": {"original_bigg_ids": ["3gmp_p"]}, "charge": -2, "formula": "C10H12N5O8P", "compartment": "p", "id": "3gmp_p"}, {"name": "3'-UMP", "notes": {"original_bigg_ids": ["3ump_p"]}, "charge": -2, "formula": "C9H11N2O9P", "compartment": "p", "id": "3ump_p"}, {"name": "4-Hydroxyphenylacetaldehyde", "notes": {"original_bigg_ids": ["4hoxpacd_p"]}, "charge": 0, "formula": "C8H8O2", "compartment": "p", "id": "4hoxpacd_p"}, {"name": "N-Acetyl-D-galactosamine", "notes": {"original_bigg_ids": ["acgal_p"]}, "charge": 0, "formula": "C8H15NO6", "compartment": "p", "id": "acgal_p"}, {"name": "N-Acetyl-D-galactosamine 1-phosphate", "notes": {"original_bigg_ids": ["acgal1p_p"]}, "charge": -2, "formula": "C8H14NO9P", "compartment": "p", "id": "acgal1p_p"}, {"name": "N-Acetylmuramate", "notes": {"original_bigg_ids": ["acmum_p"]}, "charge": -1, "formula": "C11H18NO8", "compartment": "p", "id": "acmum_p"}, {"name": "4-Amino-4-deoxy-L-arabinose modified core oligosaccharide lipid A", "notes": {"original_bigg_ids": ["acolipa_p"]}, "charge": -9, "formula": "C181H314N3O103P4", "compartment": "p", "id": "acolipa_p"}, {"name": "Arbutin", "notes": {"original_bigg_ids": ["arbt_p"]}, "charge": 0, "formula": "C12H16O7", "compartment": "p", "id": "arbt_p"}, {"name": "L-Ascorbate", "notes": {"original_bigg_ids": ["ascb_DASH_L_p"]}, "charge": 0, "formula": "C6H8O6", "compartment": "p", "id": "ascb__L_p"}, {"name": "N,N'-diacetylchitobiose", "notes": {"original_bigg_ids": ["chtbs_p"]}, "charge": 0, "formula": "C16H28N2O11", "compartment": "p", "id": "chtbs_p"}, {"name": "Chloramphenicol", "notes": {"original_bigg_ids": ["cm_p"]}, "charge": 0, "formula": "C11H12Cl2N2O5", "compartment": "p", "id": "cm_p"}, {"name": "Core oligosaccharide lipid A diphosphate", "notes": {"original_bigg_ids": ["colipap_p"]}, "charge": -12, "formula": "C176H303N2O103P5", "compartment": "p", "id": "colipap_p"}, {"name": "Dopamine", "notes": {"original_bigg_ids": ["dopa_p"]}, "charge": 1, "formula": "C8H12NO2", "compartment": "p", "id": "dopa_p"}, {"name": "Doxorubicin", "notes": {"original_bigg_ids": ["doxrbcn_p"]}, "charge": 0, "formula": "C27H29NO11", "compartment": "p", "id": "doxrbcn_p"}, {"name": "(enterobacterial common antigen)x4 core oligosaccharide lipid A", "notes": {"original_bigg_ids": ["eca4colipa_p"]}, "charge": -15, "formula": "C272H447N14O160P4", "compartment": "p", "id": "eca4colipa_p"}, {"name": "Phosphoethanolamine KDO(2)-lipid (A)", "notes": {"original_bigg_ids": ["enlipa_p"]}, "charge": -6, "formula": "C112H202N3O42P3", "compartment": "p", "id": "enlipa_p"}, {"name": "Fe(III)dicitrate", "notes": {"original_bigg_ids": ["fe3dcit_p"]}, "charge": -3, "formula": "C12H10FeO14", "compartment": "p", "id": "fe3dcit_p"}, {"name": "Fusidic acid", "notes": {"original_bigg_ids": ["fusa_p"]}, "charge": 0, "formula": "C31H48O5", "compartment": "p", "id": "fusa_p"}, {"name": "Beta D-Galactose", "notes": {"original_bigg_ids": ["gal_DASH_bD_p"]}, "charge": 0, "formula": "C6H12O6", "compartment": "p", "id": "gal_bD_p"}, {"name": "Galactitol", "notes": {"original_bigg_ids": ["galt_p"]}, "charge": 0, "formula": "C6H14O6", "compartment": "p", "id": "galt_p"}, {"name": "D-Glucosamine", "notes": {"original_bigg_ids": ["gam_p"]}, "charge": 1, "formula": "C6H14NO5", "compartment": "p", "id": "gam_p"}, {"name": "D-Glucuronate 1-phosphate", "notes": {"original_bigg_ids": ["glcur1p_p"]}, "charge": -3, "formula": "C6H8O10P", "compartment": "p", "id": "glcur1p_p"}, {"name": "2(alpha-D-Mannosyl)-D-glycerate", "notes": {"original_bigg_ids": ["manglyc_p"]}, "charge": -1, "formula": "C9H15O9", "compartment": "p", "id": "manglyc_p"}, {"name": "Minocycline", "notes": {"original_bigg_ids": ["mincyc_p"]}, "charge": 0, "formula": "C23H27N3O7", "compartment": "p", "id": "mincyc_p"}, {"name": "Myo-Inositol hexakisphosphate", "notes": {"original_bigg_ids": ["minohp_p"]}, "charge": -12, "formula": "C6H6O24P6", "compartment": "p", "id": "minohp_p"}, {"name": "D-Mannitol", "notes": {"original_bigg_ids": ["mnl_p"]}, "charge": 0, "formula": "C6H14O6", "compartment": "p", "id": "mnl_p"}, {"name": "Novobiocin", "notes": {"original_bigg_ids": ["novbcn_p"]}, "charge": 0, "formula": "C31H36N2O11", "compartment": "p", "id": "novbcn_p"}, {"name": "(O16 antigen)x4 core oligosaccharide lipid A", "notes": {"original_bigg_ids": ["o16a4colipa_p"]}, "charge": -11, "formula": "C312H523N6O200P4", "compartment": "p", "id": "o16a4colipa_p"}, {"name": "Phenethylamine", "notes": {"original_bigg_ids": ["peamn_p"]}, "charge": 1, "formula": "C8H12N", "compartment": "p", "id": "peamn_p"}, {"name": "Phosphonate", "notes": {"original_bigg_ids": ["ppt_p"]}, "charge": -2, "formula": "HO3P", "compartment": "p", "id": "ppt_p"}, {"name": "Rifampin", "notes": {"original_bigg_ids": ["rfamp_p"]}, "charge": 0, "formula": "C43H58N4O12", "compartment": "p", "id": "rfamp_p"}, {"name": "D-Sorbitol", "notes": {"original_bigg_ids": ["sbt_DASH_D_p"]}, "charge": 0, "formula": "C6H14O6", "compartment": "p", "id": "sbt__D_p"}, {"name": "Sucrose", "notes": {"original_bigg_ids": ["sucr_p"]}, "charge": 0, "formula": "C12H22O11", "compartment": "p", "id": "sucr_p"}, {"name": "L-Threonine O-3-phosphate", "notes": {"original_bigg_ids": ["thrp_p"]}, "charge": -2, "formula": "C4H8NO6P", "compartment": "p", "id": "thrp_p"}, {"name": "Tetracycline", "notes": {"original_bigg_ids": ["ttrcyc_p"]}, "charge": 0, "formula": "C22H24N2O8", "compartment": "p", "id": "ttrcyc_p"}, {"name": "Tyramine", "notes": {"original_bigg_ids": ["tym_p"]}, "charge": 1, "formula": "C8H12NO", "compartment": "p", "id": "tym_p"}, {"name": "Phosphotyrosine", "notes": {"original_bigg_ids": ["tyrp_p"]}, "charge": -2, "formula": "C9H10NO6P", "compartment": "p", "id": "tyrp_p"}, {"name": "UDP-N-acetyl-D-galactosamine", "notes": {"original_bigg_ids": ["udpacgal_p"]}, "charge": -2, "formula": "C17H25N3O17P2", "compartment": "p", "id": "udpacgal_p"}, {"name": "1-Acyl-sn-glycero-3-phosphoethanolamine (n-C12:0)", "notes": {"original_bigg_ids": ["1agpe120_p"]}, "charge": 0, "formula": "C17H36NO7P1", "compartment": "p", "id": "1agpe120_p"}, {"name": "1-Acyl-sn-glycero-3-phosphoethanolamine (n-C14:0)", "notes": {"original_bigg_ids": ["1agpe140_p"]}, "charge": 0, "formula": "C19H40NO7P1", "compartment": "p", "id": "1agpe140_p"}, {"name": "1-Acyl-sn-glycero-3-phosphoethanolamine (n-C14:1)", "notes": {"original_bigg_ids": ["1agpe141_p"]}, "charge": 0, "formula": "C19H38NO7P1", "compartment": "p", "id": "1agpe141_p"}, {"name": "1-Acyl-sn-glycero-3-phosphoethanolamine (n-C16:0)", "notes": {"original_bigg_ids": ["1agpe160_p"]}, "charge": 0, "formula": "C21H44NO7P1", "compartment": "p", "id": "1agpe160_p"}, {"name": "1-Acyl-sn-glycero-3-phosphoethanolamine (n-C16:1)", "notes": {"original_bigg_ids": ["1agpe161_p"]}, "charge": 0, "formula": "C21H42NO7P1", "compartment": "p", "id": "1agpe161_p"}, {"name": "1-Acyl-sn-glycero-3-phosphoethanolamine (n-C18:0)", "notes": {"original_bigg_ids": ["1agpe180_p"]}, "charge": 0, "formula": "C23H48NO7P1", "compartment": "p", "id": "1agpe180_p"}, {"name": "1-Acyl-sn-glycero-3-phosphoethanolamine (n-C18:1)", "notes": {"original_bigg_ids": ["1agpe181_p"]}, "charge": 0, "formula": "C23H46NO7P1", "compartment": "p", "id": "1agpe181_p"}, {"name": "1-Acyl-sn-glycero-3-phosphoglycerol (n-C12:0)", "notes": {"original_bigg_ids": ["1agpg120_p"]}, "charge": -1, "formula": "C18H36O9P1", "compartment": "p", "id": "1agpg120_p"}, {"name": "1-Acyl-sn-glycero-3-phosphoglycerol (n-C14:0)", "notes": {"original_bigg_ids": ["1agpg140_p"]}, "charge": -1, "formula": "C20H40O9P1", "compartment": "p", "id": "1agpg140_p"}, {"name": "1-Acyl-sn-glycero-3-phosphoglycerol (n-C14:1)", "notes": {"original_bigg_ids": ["1agpg141_p"]}, "charge": -1, "formula": "C20H38O9P1", "compartment": "p", "id": "1agpg141_p"}, {"name": "1-Acyl-sn-glycero-3-phosphoglycerol (n-C16:0)", "notes": {"original_bigg_ids": ["1agpg160_p"]}, "charge": -1, "formula": "C22H44O9P1", "compartment": "p", "id": "1agpg160_p"}, {"name": "1-Acyl-sn-glycero-3-phosphoglycerol (n-C16:1)", "notes": {"original_bigg_ids": ["1agpg161_p"]}, "charge": -1, "formula": "C22H42O9P1", "compartment": "p", "id": "1agpg161_p"}, {"name": "1-Acyl-sn-glycero-3-phosphoglycerol (n-C18:0)", "notes": {"original_bigg_ids": ["1agpg180_p"]}, "charge": -1, "formula": "C24H48O9P1", "compartment": "p", "id": "1agpg180_p"}, {"name": "1-Acyl-sn-glycero-3-phosphoglycerol (n-C18:1)", "notes": {"original_bigg_ids": ["1agpg181_p"]}, "charge": -1, "formula": "C24H46O9P1", "compartment": "p", "id": "1agpg181_p"}, {"name": "Applipoprotein", "notes": {"original_bigg_ids": ["alpp_p"]}, "charge": 0, "formula": "X", "compartment": "p", "id": "alpp_p"}, {"name": "Cardiolipin (tetradodecanoyl, n-C12:0)", "notes": {"original_bigg_ids": ["clpn120_p"]}, "charge": -2, "formula": "C57H108O17P2", "compartment": "p", "id": "clpn120_p"}, {"name": "Cardiolipin (tetratetradecanoyl, n-C14:0)", "notes": {"original_bigg_ids": ["clpn140_p"]}, "charge": -2, "formula": "C65H124O17P2", "compartment": "p", "id": "clpn140_p"}, {"name": "Cardiolipin (tetratetradec-7-enoyl, n-C14:1)", "notes": {"original_bigg_ids": ["clpn141_p"]}, "charge": -2, "formula": "C65H116O17P2", "compartment": "p", "id": "clpn141_p"}, {"name": "Cardiolipin (tetrahexadecanoyl, n-C16:0)", "notes": {"original_bigg_ids": ["clpn160_p"]}, "charge": -2, "formula": "C73H140O17P2", "compartment": "p", "id": "clpn160_p"}, {"name": "Cardiolipin (tetrahexadec-9-enoyl, n-C16:1)", "notes": {"original_bigg_ids": ["clpn161_p"]}, "charge": -2, "formula": "C73H132O17P2", "compartment": "p", "id": "clpn161_p"}, {"name": "Cardiolipin (tetraoctadecanoyl, n-C18:0)", "notes": {"original_bigg_ids": ["clpn180_p"]}, "charge": -2, "formula": "C81H156O17P2", "compartment": "p", "id": "clpn180_p"}, {"name": "Cardiolipin (tetraoctadec-11-enoyl, n-C18:1)", "notes": {"original_bigg_ids": ["clpn181_p"]}, "charge": -2, "formula": "C81H148O17P2", "compartment": "p", "id": "clpn181_p"}, {"name": "Periplasmic protein disulfide isomerase I (oxidized)", "notes": {"original_bigg_ids": ["dsbaox_p"]}, "charge": 0, "formula": "X", "compartment": "p", "id": "dsbaox_p"}, {"name": "Periplasmic protein disulfide isomerase I (reduced)", "notes": {"original_bigg_ids": ["dsbard_p"]}, "charge": 0, "formula": "XH2", "compartment": "p", "id": "dsbard_p"}, {"name": "Protein disulfide isomerase II (oxidized)", "notes": {"original_bigg_ids": ["dsbcox_p"]}, "charge": 0, "formula": "X", "compartment": "p", "id": "dsbcox_p"}, {"name": "Protein disulfide isomerase II (reduced)", "notes": {"original_bigg_ids": ["dsbcrd_p"]}, "charge": 0, "formula": "XH2", "compartment": "p", "id": "dsbcrd_p"}, {"name": "Periplasmic disulfide isomerase/thiol-disulphide oxidase (oxidized)", "notes": {"original_bigg_ids": ["dsbgox_p"]}, "charge": 0, "formula": "X", "compartment": "p", "id": "dsbgox_p"}, {"name": "Periplasmic disulfide isomerase/thiol-disulphide oxidase (reduced)", "notes": {"original_bigg_ids": ["dsbgrd_p"]}, "charge": 0, "formula": "XH2", "compartment": "p", "id": "dsbgrd_p"}, {"name": "(enterobacterial common antigen)x2 undecaprenyl-diphosphate", "notes": {"original_bigg_ids": ["eca2und_p"]}, "charge": -4, "formula": "C103H162N6O37P2", "compartment": "p", "id": "eca2und_p"}, {"name": "(enterobacterial common antigen)x3 undecaprenyl-diphosphate", "notes": {"original_bigg_ids": ["eca3und_p"]}, "charge": -5, "formula": "C127H198N9O52P2", "compartment": "p", "id": "eca3und_p"}, {"name": "(enterobacterial common antigen)x4 undecaprenyl-diphosphate", "notes": {"original_bigg_ids": ["eca4und_p"]}, "charge": -6, "formula": "C151H234N12O67P2", "compartment": "p", "id": "eca4und_p"}, {"name": "Lipoprotein", "notes": {"original_bigg_ids": ["lpp_p"]}, "charge": 0, "formula": "XC16H30O1", "compartment": "p", "id": "lpp_p"}, {"name": "Two linked disacharide tripeptide murein units (uncrosslinked, middle of chain)", "notes": {"original_bigg_ids": ["murein3p3p_p"]}, "charge": -4, "formula": "C68H104N12O38", "compartment": "p", "id": "murein3p3p_p"}, {"name": "Two disacharide linked murein units, tripeptide crosslinked tripeptide (A2pm->A2pm) (middle of chain)", "notes": {"original_bigg_ids": ["murein3px3p_p"]}, "charge": -4, "formula": "C68H102N12O37", "compartment": "p", "id": "murein3px3p_p"}, {"name": "Two disacharide linked murein units, tripeptide crosslinked tetrapeptide (A2pm->D-ala) (middle of chain)", "notes": {"original_bigg_ids": ["murein3px4p_p"]}, "charge": -4, "formula": "C71H107N13O38", "compartment": "p", "id": "murein3px4p_p"}, {"name": "Two linked disacharide tetrapeptide and tripeptide murein units (uncrosslinked, middle of chain)", "notes": {"original_bigg_ids": ["murein4p3p_p"]}, "charge": -4, "formula": "C71H109N13O39", "compartment": "p", "id": "murein4p3p_p"}, {"name": "Two linked disacharide tetrapeptide murein units (uncrosslinked, middle of chain)", "notes": {"original_bigg_ids": ["murein4p4p_p"]}, "charge": -4, "formula": "C74H114N14O40", "compartment": "p", "id": "murein4p4p_p"}, {"name": "Two disacharide linked murein units, tetrapeptide corsslinked tetrapeptide (A2pm->D-ala) (middle of chain)", "notes": {"original_bigg_ids": ["murein4px4p_p"]}, "charge": -4, "formula": "C74H112N14O39", "compartment": "p", "id": "murein4px4p_p"}, {"name": "Three disacharide linked murein units (tetrapeptide crosslinked tetrapeptide (A2pm->D-ala), one uncrosslinked tetrapaptide) (middle of chain)", "notes": {"original_bigg_ids": ["murein4px4p4p_p"]}, "charge": -6, "formula": "C111H169N21O59", "compartment": "p", "id": "murein4px4p4p_p"}, {"name": "Three disacharide linked murein units (tetrapeptide crosslinked tetrapeptide (A2pm->D-ala) & tetrapeptide corsslinked tetrapeptide (A2pm->D-ala)) (middle of chain)", "notes": {"original_bigg_ids": ["murein4px4px4p_p"]}, "charge": -6, "formula": "C111H167N21O58", "compartment": "p", "id": "murein4px4px4p_p"}, {"name": "Two linked disacharide pentapeptide and tripeptide murein units (uncrosslinked, middle of chain)", "notes": {"original_bigg_ids": ["murein5p3p_p"]}, "charge": -4, "formula": "C74H114N14O40", "compartment": "p", "id": "murein5p3p_p"}, {"name": "Two linked disacharide pentapeptide and tetrapeptide murein units (uncrosslinked, middle of chain)", "notes": {"original_bigg_ids": ["murein5p4p_p"]}, "charge": -4, "formula": "C77H119N15O41", "compartment": "p", "id": "murein5p4p_p"}, {"name": "Two linked disacharide pentapeptide murein units (uncrosslinked, middle of chain)", "notes": {"original_bigg_ids": ["murein5p5p_p"]}, "charge": -4, "formula": "C80H124N16O42", "compartment": "p", "id": "murein5p5p_p"}, {"name": "Three linked disacharide pentapeptide murein units (uncrosslinked, middle of chain)", "notes": {"original_bigg_ids": ["murein5p5p5p_p"]}, "charge": -6, "formula": "C120H186N24O63", "compartment": "p", "id": "murein5p5p5p_p"}, {"name": "Two disacharide linked murein units, pentapeptide corsslinked tripeptide (A2pm->A2pm) (middle of chain)", "notes": {"original_bigg_ids": ["murein5px3p_p"]}, "charge": -4, "formula": "C74H112N14O39", "compartment": "p", "id": "murein5px3p_p"}, {"name": "Two disacharide linked murein units, pentapeptide crosslinked tetrapeptide (A2pm->D-ala) (middle of chain)", "notes": {"original_bigg_ids": ["murein5px4p_p"]}, "charge": -4, "formula": "C77H117N15O40", "compartment": "p", "id": "murein5px4p_p"}, {"name": "Three disacharide linked murein units (pentapeptide crosslinked tetrapeptide (A2pm->D-ala) tetrapeptide corsslinked tetrapeptide (A2pm->D-ala)) (middle of chain)", "notes": {"original_bigg_ids": ["murein5px4px4p_p"]}, "charge": -6, "formula": "C114H172N22O59", "compartment": "p", "id": "murein5px4px4p_p"}, {"name": "(O16 antigen)x2 undecaprenyl diphosphate", "notes": {"original_bigg_ids": ["o16a2und_p"]}, "charge": -2, "formula": "C123H200N2O57P2", "compartment": "p", "id": "o16a2und_p"}, {"name": "(O16 antigen)x3 undecaprenyl diphosphate", "notes": {"original_bigg_ids": ["o16a3und_p"]}, "charge": -2, "formula": "C157H255N3O82P2", "compartment": "p", "id": "o16a3und_p"}, {"name": "(O16 antigen)x4 undecaprenyl diphosphate", "notes": {"original_bigg_ids": ["o16a4und_p"]}, "charge": -2, "formula": "C191H310N4O107P2", "compartment": "p", "id": "o16a4und_p"}], "version": 1, "id": "iJO1366"} \ No newline at end of file diff --git a/1-0-0/6/models/Homo sapiens/RECON1.json b/1-0-0/6/models/Homo sapiens/RECON1.json new file mode 100644 index 00000000..39f2be2f --- /dev/null +++ b/1-0-0/6/models/Homo sapiens/RECON1.json @@ -0,0 +1 @@ +{"reactions": [{"subsystem": "Transport, Lysosomal", "name": "10FTHF5GLUtl", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["10FTHF5GLUtl"]}, "metabolites": {"10fthf5glu_c": -1.0, "10fthf5glu_l": 1.0}, "id": "10FTHF5GLUtl", "gene_reaction_rule": ""}, {"subsystem": "Transport, Mitochondrial", "name": "10FTHF5GLUtm", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["10FTHF5GLUtm"]}, "metabolites": {"10fthf5glu_c": 1.0, "10fthf5glu_m": -1.0}, "id": 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"upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["34DHPHAMT"]}, "metabolites": {"amet_c": -1.0, "homoval_c": 1.0, "h_c": 1.0, "ahcys_c": 1.0, "34dhpha_c": -1.0}, "id": "34DHPHAMT", "gene_reaction_rule": "1312_AT1 or 1312_AT2"}, {"subsystem": "Transport, Extracellular", "name": "34DHPHEt", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["34DHPHEt"]}, "metabolites": {"34dhphe_e": -1.0, "34dhphe_c": 1.0}, "id": "34DHPHEt", "gene_reaction_rule": "117247_AT1"}, {"subsystem": "Tyrosine metabolism", "name": "Aldehyde dehydrogenase 3 4 dihydroxyphenylacetaldehyde NAD ", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["34DHPLACOX"]}, "metabolites": {"h2o_c": -1.0, "34dhpac_c": -1.0, "34dhpha_c": 1.0, "h_c": 2.0, "nad_c": -1.0, "nadh_c": 1.0}, "id": "34DHALDD", "gene_reaction_rule": "221_AT1 or 222_AT1 or 218_AT1 or 220_AT1"}, {"subsystem": "Tyrosine metabolism", "name": "34DHPLACOX LPAREN NADP RPAREN ", 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"34DHXMANDACOX_NADP", "gene_reaction_rule": "221_AT1 or 222_AT1"}, {"subsystem": "Ubiquinone Biosynthesis", "name": "3 4 hydroxyphenyl lactate formation", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["34HPLFM"]}, "metabolites": {"34hpl_m": 1.0, "nad_m": 1.0, "h_m": -1.0, "34hpp_m": -1.0, "nadh_m": -1.0}, "id": "34HPLFM", "gene_reaction_rule": ""}, {"subsystem": "Tyrosine metabolism", "name": "4 Hydroxyphenylpyruvateoxygen oxidoreductase", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["34HPPOR"]}, "metabolites": {"o2_c": -1.0, "34hpp_c": -1.0, "co2_c": 1.0, "hgentis_c": 1.0}, "id": "34HPPOR", "gene_reaction_rule": "3242_AT1"}, {"subsystem": "Transport, Nuclear", "name": "35CGMPtn", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["35CGMPtn"]}, "metabolites": {"35cgmp_n": 1.0, "35cgmp_c": -1.0}, "id": "35CGMPtn", "gene_reaction_rule": ""}, {"subsystem": "Valine, Leucine, and Isoleucine 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"h_m": -1.0}, "id": "3DPHBH1", "gene_reaction_rule": ""}, {"subsystem": "Ubiquinone Biosynthesis", "name": "3DPHBH2", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["3DPHBH2"]}, "metabolites": {"3dphb_m": -1.0, "h2o_m": 1.0, "nadp_m": 1.0, "o2_m": -1.0, "3dpdhb_m": 1.0, "h_m": -1.0, "nadph_m": -1.0}, "id": "3DPHBH2", "gene_reaction_rule": ""}, {"subsystem": "Sphingolipid Metabolism", "name": "3 Dehydrosphinganine reductase", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["3DSPHR"]}, "metabolites": {"nadph_c": -1.0, "nadp_c": 1.0, "3dsphgn_c": -1.0, "h_c": -1.0, "sphgn_c": 1.0}, "id": "3DSPHR", "gene_reaction_rule": "2531_AT1"}, {"subsystem": "Tryptophan metabolism", "name": "3 hydroxyanthranilate 3 4 dioxygenase", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["3HAO"]}, "metabolites": {"cmusa_c": 1.0, "o2_c": -1.0, "3hanthrn_c": -1.0, "h_c": 1.0}, "id": "3HAO", "gene_reaction_rule": "23498_AT1"}, {"subsystem": "Butanoate Metabolism", "name": "3HBCDm", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["3HBCDm"]}, "metabolites": {"h2o_m": -1.0, "3hbcoa__R_m": 1.0, "b2coa_m": -1.0}, "id": "3HBCDm", "gene_reaction_rule": "55268_AT1"}, {"subsystem": "Valine, Leucine, and Isoleucine Metabolism", "name": "3HBCOAHLm", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["3HBCOAHLm"]}, "metabolites": {"3hmp_m": 1.0, "3hibutcoa_m": -1.0, "coa_m": 1.0, "h_m": 1.0, "h2o_m": -1.0}, "id": "3HBCOAHLm", "gene_reaction_rule": ""}, {"subsystem": "Transport, Extracellular", "name": "3HCO3 NAt", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["3HCO3_NAt"]}, "metabolites": {"hco3_c": 3.0, "na1_c": 1.0, "na1_e": -1.0, "hco3_e": -3.0}, "id": "3HCO3_NAt", "gene_reaction_rule": "57835_AT3 or 8671_AT1 or 57835_AT2 or 57835_AT1 or 57835_AT4"}, {"subsystem": "Tryptophan metabolism", "name": "3HKYNAKGAT", 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"metabolites": {"3hpp_c": -1.0, "nadh_c": 1.0, "nad_c": -1.0, "msa_c": 1.0, "h_c": 1.0}, "id": "3HPPD", "gene_reaction_rule": ""}, {"subsystem": "Tryptophan metabolism", "name": "3HXKYNDCL", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["3HXKYNDCL"]}, "metabolites": {"3hxkynam_c": 1.0, "hLkynr_c": -1.0, "co2_c": 1.0, "h_c": -1.0}, "id": "3HXKYNDCL", "gene_reaction_rule": "1644_AT1"}, {"subsystem": "Tryptophan metabolism", "name": "3HXKYNOXDA", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["3HXKYNOXDA"]}, "metabolites": {"3hxkynam_c": -1.0, "o2_c": -1.0, "48dhoxquin_c": 1.0, "nh4_c": 1.0, "h2o2_c": 1.0}, "id": "3HXKYNOXDA", "gene_reaction_rule": "4128_AT1 or 4129_AT1"}, {"subsystem": "Tyrosine metabolism", "name": "3M4HDXPAC", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["3M4HDXPAC"]}, "metabolites": {"h2o_c": -1.0, "homoval_c": 1.0, "h_c": 2.0, "nad_c": -1.0, "nadh_c": 1.0, 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"id": "ABUTt4_2_r", "gene_reaction_rule": "6529_AT1 or 6538_AT1 or 6540_AT1 or 6539_AT1"}, {"subsystem": "Cholesterol Metabolism", "name": "Acetyl-CoA C-acetyltransferase", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ACACT1", "ACACT1r"]}, "metabolites": {"aacoa_c": 1.0, "coa_c": 1.0, "accoa_c": -2.0}, "id": "ACACT1r_copy1", "gene_reaction_rule": "39_AT1"}, {"subsystem": "Valine, Leucine, and Isoleucine Metabolism", "name": "ACACT10m", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["ACACT10m"]}, "metabolites": {"ppcoa_m": 1.0, "accoa_m": 1.0, "coa_m": -1.0, "2maacoa_m": -1.0}, "id": "ACACT10m", "gene_reaction_rule": "38_AT1"}, {"subsystem": "Tryptophan metabolism", "name": "Acetyl-CoA C-acetyltransferase", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["ACACT1", "ACACT1r"]}, "metabolites": {"aacoa_c": 1.0, "coa_c": 1.0, "accoa_c": -2.0}, "id": "ACACT1r_copy2", "gene_reaction_rule": 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374907_AT2 or 10678_AT2 or 79369_AT1"}, {"subsystem": "Keratan sulfate biosynthesis", "name": "AG13T6g", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AG13T6g"]}, "metabolites": {"ksi_pre7_g": 1.0, "h_g": 1.0, "uacgam_g": -1.0, "udp_g": 1.0, "ksi_pre6_g": -1.0}, "id": "AG13T6g", "gene_reaction_rule": "11041_AT1 or 10678_AT1 or 93010_AT1 or 10331_AT1 or 374907_AT1 or 284208_AT1 or 374907_AT2 or 10678_AT2 or 79369_AT1"}, {"subsystem": "Keratan sulfate biosynthesis", "name": "AG13T7g", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AG13T7g"]}, "metabolites": {"h_g": 1.0, "ksi_pre9_g": -1.0, "uacgam_g": -1.0, "udp_g": 1.0, "ksi_pre10_g": 1.0}, "id": "AG13T7g", "gene_reaction_rule": "11041_AT1 or 10678_AT1 or 93010_AT1 or 10331_AT1 or 374907_AT1 or 284208_AT1 or 374907_AT2 or 10678_AT2 or 79369_AT1"}, {"subsystem": "Keratan sulfate biosynthesis", "name": "AG13T8g", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": 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"name": "ASNSERNaEx", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ASNSERNaEx"]}, "metabolites": {"asn__L_c": 1.0, "na1_c": 1.0, "asn__L_e": -1.0, "na1_e": -1.0, "ser__L_c": -1.0, "ser__L_e": 1.0}, "id": "ASNSERNaEx", "gene_reaction_rule": "6510_AT1"}, {"subsystem": "Transport, Extracellular", "name": "ASNTHRNaEx", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ASNTHRNaEx"]}, "metabolites": {"asn__L_c": 1.0, "na1_c": 1.0, "asn__L_e": -1.0, "na1_e": -1.0, "thr__L_c": -1.0, "thr__L_e": 1.0}, "id": "ASNTHRNaEx", "gene_reaction_rule": "6510_AT1"}, {"subsystem": "Transport, Extracellular", "name": "ASNt4", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ASNt4"]}, "metabolites": {"asn__L_c": 1.0, "na1_c": 1.0, "asn__L_e": -1.0, "na1_e": -1.0}, "id": "ASNt4", "gene_reaction_rule": "81539_AT1 or 11254_AT1 or 54407_AT1 or 55089_AT1"}, {"subsystem": "Transport, Extracellular", "name": "ASNtN1", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["ASNtN1"]}, "metabolites": {"asn__L_c": 1.0, "na1_c": 2.0, "asn__L_e": -1.0, "na1_e": -2.0, "h_e": 1.0, "h_c": -1.0}, "id": "ASNtN1", "gene_reaction_rule": "10991_AT1 or 92745_AT1"}, {"subsystem": "Transport, Mitochondrial", "name": "ASNtm", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ASNtm"]}, "metabolites": {"asn__L_c": -1.0, "asn__L_m": 1.0}, "id": "ASNtm", "gene_reaction_rule": ""}, {"subsystem": "beta-Alanine metabolism", "name": "Aspartate 1-decarboxylase", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ASP1DC"]}, "metabolites": {"asp__L_c": -1.0, "co2_c": 1.0, "h_c": -1.0, "ala_B_c": 1.0}, "id": "ASP1DC", "gene_reaction_rule": "2571_AT1 or 2571_AT2"}, {"subsystem": "Pyrimidine Biosynthesis", "name": "Aspartate carbamoyltransferase", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["ASPCTr"]}, "metabolites": {"asp__L_c": -1.0, "cbasp_c": 1.0, "cbp_c": -1.0, "pi_c": 1.0, "h_c": 1.0}, "id": "ASPCT", "gene_reaction_rule": "790_AT1"}, {"subsystem": "Transport, Extracellular", "name": "ASPDt6", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ASPDt6"]}, "metabolites": {"asp__D_c": 1.0, "asp__D_e": -1.0, "na1_c": 3.0, "na1_e": -3.0, "h_e": -1.0, "h_c": 1.0, "k_c": -1.0, "k_e": 1.0}, "id": "ASPDt6", "gene_reaction_rule": "6511_AT1 or 6505_AT1 or 6507_AT1 or 6506_AT1 or 6512_AT1"}, {"subsystem": "Transport, Peroxisomal", "name": "ASPDxt", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["ASPDxt"]}, "metabolites": {"asp__D_c": 1.0, "asp__D_x": -1.0}, "id": "ASPDxt", "gene_reaction_rule": ""}, {"subsystem": "Transport, Mitochondrial", "name": "ASPGLUm", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["ASPGLUm"]}, "metabolites": {"glu__L_m": 1.0, "asp__L_m": -1.0, "asp__L_c": 1.0, "glu__L_c": -1.0, "h_c": -1.0, "h_m": 1.0}, "id": "ASPGLUm", "gene_reaction_rule": "8604_AT1 or 10165_AT1"}, {"subsystem": "Alanine and Aspartate Metabolism", "name": "ASPNATm", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ASPNATm"]}, "metabolites": {"accoa_m": -1.0, "coa_m": 1.0, "h_m": 1.0, "asp__L_m": -1.0, "Nacasp_m": 1.0}, "id": "ASPNATm", "gene_reaction_rule": ""}, {"subsystem": "Alanine and Aspartate Metabolism", "name": "Aspartate transaminase", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["ASPTA"]}, "metabolites": {"akg_c": -1.0, "asp__L_c": -1.0, "glu__L_c": 1.0, "oaa_c": 1.0}, "id": "ASPTA", "gene_reaction_rule": "2805_AT1"}, {"subsystem": "Alanine and Aspartate Metabolism", "name": "Aspartate transaminase", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["ASPTAm"]}, "metabolites": {"oaa_m": 1.0, "glu__L_m": 1.0, "akg_m": -1.0, "asp__L_m": -1.0}, "id": "ASPTAm", "gene_reaction_rule": "2806_AT1"}, {"subsystem": "Transport, Extracellular", "name": "ASPt6", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ASPt6"]}, "metabolites": {"asp__L_c": 1.0, "na1_c": 3.0, "na1_e": -3.0, "asp__L_e": -1.0, "h_e": -1.0, "h_c": 1.0, "k_c": -1.0, "k_e": 1.0}, "id": "ASPt6", "gene_reaction_rule": "6511_AT1 or 6505_AT1 or 6507_AT1 or 6506_AT1 or 6512_AT1"}, {"subsystem": "Transport, Endoplasmic Reticular", "name": "ATP1ter", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["ATP1ter"]}, "metabolites": {"atp_r": 1.0, "adp_c": 1.0, "atp_c": -1.0, "adp_r": -1.0}, "id": "ATP1ter", "gene_reaction_rule": ""}, {"subsystem": "Transport, Endoplasmic Reticular", "name": "ATP2ter", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["ATP2ter"]}, "metabolites": {"amp_r": -1.0, "amp_c": 1.0, "atp_c": -1.0, "atp_r": 1.0}, "id": "ATP2ter", "gene_reaction_rule": ""}, {"subsystem": "Nucleotides", "name": "ATPH1e", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ATPH1e"]}, "metabolites": {"atp_e": -1.0, "h_e": 2.0, "h2o_e": -2.0, "pi_e": 2.0, "amp_e": 1.0}, "id": "ATPH1e", "gene_reaction_rule": "954_AT1 or 954_AT2 or 953_AT1 or 956_AT1 or 955_AT1 or 957_AT1"}, {"subsystem": "Nucleotides", "name": "ATPH2e", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ATPH2e"]}, "metabolites": {"adp_e": -1.0, "h2o_e": -1.0, "amp_e": 1.0, "h_e": 1.0, "pi_e": 1.0}, "id": "ATPH2e", "gene_reaction_rule": "954_AT2 or 954_AT1 or 953_AT1 or 956_AT1 or 955_AT1 or 957_AT1"}, {"subsystem": "Oxidative Phosphorylation", "name": "ATPS4m", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ATPS4m"]}, "metabolites": {"atp_m": 1.0, "h2o_m": 1.0, "pi_m": -1.0, "adp_m": -1.0, "h_m": 3.0, "h_c": -4.0}, "id": "ATPS4m", "gene_reaction_rule": "((513_AT1 and 498_AT2 and 506_AT1 and 509_AT2 and 514_AT1) or (498_AT2 and 513_AT2 and 514_AT2 and 506_AT1 and 509_AT2) or (513_AT1 and 509_AT1 and 498_AT1 and 514_AT2 and 506_AT1) or (498_AT2 and 513_AT2 and 506_AT1 and 509_AT2 and 514_AT1) or (513_AT2 and 498_AT1 and 514_AT2 and 506_AT1 and 509_AT2) or (513_AT1 and 498_AT1 and 506_AT1 and 509_AT2 and 514_AT1) or (513_AT1 and 498_AT2 and 514_AT2 and 506_AT1 and 509_AT2) or (513_AT1 and 498_AT2 and 509_AT1 and 506_AT1 and 514_AT1) or (498_AT2 and 509_AT1 and 513_AT2 and 506_AT1 and 514_AT1) or (513_AT2 and 498_AT1 and 506_AT1 and 509_AT2 and 514_AT1) or (513_AT2 and 514_AT2 and 506_AT1 and 509_AT2 and 498_AT3) or (513_AT2 and 506_AT1 and 509_AT2 and 498_AT3 and 514_AT1) or (513_AT1 and 509_AT1 and 506_AT1 and 498_AT3 and 514_AT1) or (509_AT1 and 513_AT2 and 514_AT2 and 506_AT1 and 498_AT3) or (513_AT1 and 498_AT2 and 509_AT1 and 514_AT2 and 506_AT1) or (513_AT1 and 498_AT1 and 514_AT2 and 506_AT1 and 509_AT2) or (513_AT1 and 509_AT1 and 498_AT1 and 506_AT1 and 514_AT1) or (513_AT1 and 506_AT1 and 509_AT2 and 498_AT3 and 514_AT1) or (509_AT1 and 513_AT2 and 506_AT1 and 498_AT3 and 514_AT1) or (513_AT1 and 514_AT2 and 506_AT1 and 509_AT2 and 498_AT3) or (509_AT1 and 513_AT2 and 498_AT1 and 506_AT1 and 514_AT1) or (513_AT1 and 509_AT1 and 514_AT2 and 506_AT1 and 498_AT3) or (498_AT2 and 509_AT1 and 513_AT2 and 514_AT2 and 506_AT1) or (509_AT1 and 513_AT2 and 498_AT1 and 514_AT2 and 506_AT1)) and ((4905_AT1 and 516_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 522_AT5) or (518_AT3 and 4905_AT1 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 9551_AT3 and 522_AT3) or (4905_AT1 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 517_AT2 and 9551_AT2 and 522_AT3) or (4905_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 522_AT5 and 518_AT2 and 9551_AT2) or (4905_AT1 and 515_AT2 and 10476_AT2 and 516_AT2 and 521_AT1 and 10632_AT1 and 9551_AT3 and 522_AT5) or (518_AT3 and 4905_AT1 and 9551_AT1 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 522_AT4) or (4905_AT1 and 9551_AT1 and 522_AT2 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 518_AT2) or (518_AT3 and 4905_AT1 and 515_AT3 and 521_AT1 and 10632_AT1 and 10476_AT1 and 522_AT4 and 9551_AT2) or (4905_AT1 and 515_AT3 and 522_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 518_AT2) or (4905_AT1 and 9551_AT1 and 10476_AT2 and 522_AT1 and 516_AT2 and 521_AT1 and 515_AT1 and 10632_AT1) or (517_AT1 and 4905_AT1 and 522_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT2) or (4905_AT1 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 522_AT5 and 518_AT2) or (4905_AT1 and 516_AT1 and 9551_AT1 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 522_AT3) or (4905_AT1 and 9551_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 522_AT4 and 518_AT2) or (4905_AT1 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 9551_AT3 and 522_AT5 and 518_AT2) or (4905_AT1 and 9551_AT1 and 515_AT2 and 10476_AT2 and 516_AT2 and 521_AT1 and 10632_AT1 and 522_AT3) or (4905_AT1 and 516_AT1 and 9551_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 522_AT3) or (4905_AT1 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 522_AT5 and 518_AT2 and 9551_AT2) or (4905_AT1 and 9551_AT1 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 518_AT2 and 522_AT3) or (517_AT1 and 4905_AT1 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 522_AT4) or (4905_AT1 and 10476_AT2 and 522_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 518_AT2 and 9551_AT2) or (4905_AT1 and 522_AT2 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 517_AT2 and 9551_AT2) or (517_AT1 and 4905_AT1 and 9551_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 522_AT4) or (518_AT3 and 4905_AT1 and 515_AT3 and 10476_AT2 and 521_AT1 and 10632_AT1 and 9551_AT3 and 522_AT4) or (4905_AT1 and 515_AT3 and 522_AT1 and 521_AT1 and 10632_AT1 and 10476_AT1 and 518_AT2 and 9551_AT2) or (4905_AT1 and 9551_AT1 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 517_AT2 and 522_AT5) or (4905_AT1 and 10476_AT2 and 516_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 9551_AT3 and 522_AT3) or (518_AT3 and 4905_AT1 and 9551_AT1 and 515_AT3 and 522_AT1 and 521_AT1 and 10632_AT1 and 10476_AT1) or (4905_AT1 and 516_AT1 and 10476_AT2 and 522_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 9551_AT3) or (4905_AT1 and 515_AT3 and 522_AT2 and 10476_AT2 and 516_AT2 and 521_AT1 and 10632_AT1 and 9551_AT3) or (4905_AT1 and 9551_AT1 and 515_AT2 and 10476_AT2 and 521_AT1 and 518_AT1 and 10632_AT1 and 522_AT4) or (517_AT1 and 4905_AT1 and 9551_AT1 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 522_AT5) or (4905_AT1 and 516_AT1 and 515_AT3 and 10476_AT2 and 521_AT1 and 10632_AT1 and 522_AT4 and 9551_AT2) or (4905_AT1 and 515_AT2 and 522_AT1 and 521_AT1 and 10632_AT1 and 10476_AT1 and 517_AT2 and 9551_AT2) or (4905_AT1 and 516_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 522_AT3) or (4905_AT1 and 10476_AT2 and 521_AT1 and 518_AT1 and 515_AT1 and 10632_AT1 and 9551_AT3 and 522_AT3) or (517_AT1 and 4905_AT1 and 9551_AT1 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 522_AT3) or (4905_AT1 and 9551_AT1 and 515_AT3 and 10476_AT2 and 521_AT1 and 10632_AT1 and 518_AT2 and 522_AT3) or (518_AT3 and 4905_AT1 and 9551_AT1 and 522_AT2 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1) or (4905_AT1 and 515_AT3 and 10476_AT2 and 522_AT1 and 521_AT1 and 10632_AT1 and 518_AT2 and 9551_AT2) or (4905_AT1 and 522_AT2 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 518_AT2 and 9551_AT2) or (4905_AT1 and 515_AT3 and 522_AT2 and 10476_AT2 and 521_AT1 and 518_AT1 and 10632_AT1 and 9551_AT2) or (4905_AT1 and 515_AT2 and 10476_AT2 and 521_AT1 and 518_AT1 and 10632_AT1 and 9551_AT2 and 522_AT3) or (4905_AT1 and 522_AT2 and 10476_AT2 and 516_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 9551_AT3) or (4905_AT1 and 516_AT1 and 515_AT3 and 521_AT1 and 10632_AT1 and 10476_AT1 and 522_AT5 and 9551_AT2) or (4905_AT1 and 515_AT3 and 522_AT2 and 516_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3) or (518_AT3 and 4905_AT1 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 9551_AT3 and 522_AT5) or (4905_AT1 and 9551_AT1 and 516_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 522_AT4) or (4905_AT1 and 516_AT1 and 9551_AT1 and 522_AT2 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1) or (4905_AT1 and 521_AT1 and 518_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 522_AT5) or (517_AT1 and 4905_AT1 and 515_AT3 and 522_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT2) or (517_AT1 and 4905_AT1 and 522_AT2 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3) or (4905_AT1 and 516_AT1 and 522_AT2 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 9551_AT2) or (4905_AT1 and 516_AT1 and 515_AT3 and 522_AT1 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT2) or (4905_AT1 and 9551_AT1 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 517_AT2 and 522_AT5) or (4905_AT1 and 515_AT3 and 10476_AT2 and 521_AT1 and 10632_AT1 and 9551_AT3 and 522_AT4 and 518_AT2) or (4905_AT1 and 516_AT1 and 9551_AT1 and 515_AT3 and 10476_AT2 and 522_AT1 and 521_AT1 and 10632_AT1) or (4905_AT1 and 515_AT2 and 521_AT1 and 518_AT1 and 10632_AT1 and 10476_AT1 and 522_AT5 and 9551_AT2) or (4905_AT1 and 9551_AT1 and 522_AT2 and 515_AT2 and 516_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1) or (4905_AT1 and 515_AT3 and 10476_AT2 and 522_AT1 and 521_AT1 and 10632_AT1 and 517_AT2 and 9551_AT3) or (518_AT3 and 4905_AT1 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 522_AT5 and 9551_AT2) or (4905_AT1 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 517_AT2 and 9551_AT2 and 522_AT3) or (517_AT1 and 4905_AT1 and 9551_AT1 and 515_AT3 and 521_AT1 and 10632_AT1 and 10476_AT1 and 522_AT5) or (517_AT1 and 4905_AT1 and 9551_AT1 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 522_AT5) or (4905_AT1 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 517_AT2 and 9551_AT3 and 522_AT4) or (4905_AT1 and 515_AT3 and 522_AT1 and 516_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3) or (518_AT3 and 4905_AT1 and 515_AT3 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 522_AT5) or (4905_AT1 and 522_AT2 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 9551_AT3 and 518_AT2) or (518_AT3 and 4905_AT1 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 9551_AT2 and 522_AT3) or (517_AT1 and 4905_AT1 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 522_AT4 and 9551_AT2) or (4905_AT1 and 9551_AT1 and 515_AT3 and 522_AT1 and 516_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1) or (4905_AT1 and 10476_AT2 and 516_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 522_AT5 and 9551_AT2) or (518_AT3 and 4905_AT1 and 9551_AT1 and 515_AT3 and 10476_AT2 and 521_AT1 and 10632_AT1 and 522_AT3) or (517_AT1 and 4905_AT1 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 9551_AT3 and 522_AT4) or (4905_AT1 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 9551_AT3 and 522_AT4 and 518_AT2) or (4905_AT1 and 9551_AT1 and 515_AT2 and 521_AT1 and 518_AT1 and 10632_AT1 and 10476_AT1 and 522_AT4) or (518_AT3 and 4905_AT1 and 522_AT2 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 9551_AT2) or (4905_AT1 and 515_AT3 and 516_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 522_AT4) or (4905_AT1 and 522_AT2 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 517_AT2 and 9551_AT3) or (4905_AT1 and 516_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 522_AT4 and 9551_AT2) or (4905_AT1 and 515_AT3 and 10476_AT2 and 521_AT1 and 10632_AT1 and 517_AT2 and 9551_AT3 and 522_AT4) or (4905_AT1 and 9551_AT1 and 522_AT2 and 515_AT2 and 10476_AT2 and 516_AT2 and 521_AT1 and 10632_AT1) or (4905_AT1 and 522_AT2 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 9551_AT3 and 518_AT2) or (518_AT3 and 4905_AT1 and 9551_AT1 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 522_AT5) or (517_AT1 and 4905_AT1 and 522_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3) or (4905_AT1 and 9551_AT1 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 522_AT5 and 518_AT2) or (4905_AT1 and 9551_AT1 and 515_AT3 and 521_AT1 and 10632_AT1 and 10476_AT1 and 522_AT5 and 518_AT2) or (4905_AT1 and 9551_AT1 and 515_AT2 and 516_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 522_AT4) or (517_AT1 and 4905_AT1 and 515_AT3 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 522_AT5) or (518_AT3 and 4905_AT1 and 9551_AT1 and 515_AT3 and 522_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1) or (4905_AT1 and 522_AT2 and 521_AT1 and 518_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT2) or (517_AT1 and 4905_AT1 and 10476_AT2 and 522_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 9551_AT2) or (517_AT1 and 4905_AT1 and 9551_AT1 and 515_AT3 and 522_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1) or (518_AT3 and 4905_AT1 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 522_AT5 and 9551_AT2) or (4905_AT1 and 522_AT2 and 515_AT2 and 10476_AT2 and 521_AT1 and 518_AT1 and 10632_AT1 and 9551_AT2) or (4905_AT1 and 522_AT2 and 10476_AT2 and 521_AT1 and 518_AT1 and 515_AT1 and 10632_AT1 and 9551_AT3) or (4905_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 522_AT4 and 518_AT2) or (4905_AT1 and 516_AT1 and 522_AT2 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 9551_AT2) or (4905_AT1 and 515_AT3 and 516_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT2 and 522_AT3) or (4905_AT1 and 522_AT2 and 521_AT1 and 518_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3) or (518_AT3 and 4905_AT1 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 522_AT4) or (4905_AT1 and 516_AT1 and 515_AT3 and 10476_AT2 and 521_AT1 and 10632_AT1 and 9551_AT2 and 522_AT3) or (4905_AT1 and 515_AT2 and 516_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 522_AT3) or (4905_AT1 and 9551_AT1 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 522_AT4 and 518_AT2) or (4905_AT1 and 515_AT3 and 10476_AT2 and 521_AT1 and 10632_AT1 and 518_AT2 and 9551_AT2 and 522_AT3) or (517_AT1 and 4905_AT1 and 9551_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 522_AT5) or (4905_AT1 and 515_AT3 and 522_AT1 and 521_AT1 and 518_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT2) or (518_AT3 and 4905_AT1 and 9551_AT1 and 522_AT2 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1) or (4905_AT1 and 515_AT3 and 522_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 518_AT2 and 9551_AT2) or (4905_AT1 and 9551_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 522_AT5 and 518_AT2) or (518_AT3 and 4905_AT1 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT2 and 522_AT3) or (4905_AT1 and 516_AT1 and 10476_AT2 and 522_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 9551_AT2) or (4905_AT1 and 9551_AT1 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 518_AT2 and 522_AT3) or (4905_AT1 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 518_AT2 and 9551_AT2 and 522_AT3) or (4905_AT1 and 522_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 518_AT2) or (4905_AT1 and 516_AT1 and 522_AT2 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 9551_AT3) or (517_AT1 and 4905_AT1 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 9551_AT2 and 522_AT3) or (517_AT1 and 4905_AT1 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 522_AT5) or (4905_AT1 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 517_AT2 and 9551_AT3 and 522_AT5) or (4905_AT1 and 515_AT2 and 10476_AT2 and 521_AT1 and 518_AT1 and 10632_AT1 and 522_AT5 and 9551_AT2) or (4905_AT1 and 516_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 522_AT4) or (4905_AT1 and 521_AT1 and 518_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 522_AT4) or (4905_AT1 and 9551_AT1 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 517_AT2 and 522_AT3) or (4905_AT1 and 515_AT3 and 10476_AT2 and 521_AT1 and 518_AT1 and 10632_AT1 and 9551_AT2 and 522_AT3) or (4905_AT1 and 515_AT2 and 522_AT1 and 521_AT1 and 518_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT2) or (4905_AT1 and 516_AT1 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 522_AT4) or (4905_AT1 and 9551_AT1 and 522_AT2 and 521_AT1 and 518_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1) or (4905_AT1 and 9551_AT1 and 515_AT3 and 522_AT1 and 521_AT1 and 10632_AT1 and 10476_AT1 and 517_AT2) or (4905_AT1 and 10476_AT2 and 516_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 9551_AT3 and 522_AT4) or (517_AT1 and 4905_AT1 and 515_AT3 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT2 and 522_AT3) or (518_AT3 and 4905_AT1 and 515_AT3 and 10476_AT2 and 522_AT1 and 521_AT1 and 10632_AT1 and 9551_AT2) or (4905_AT1 and 9551_AT1 and 515_AT3 and 10476_AT2 and 521_AT1 and 518_AT1 and 10632_AT1 and 522_AT5) or (4905_AT1 and 10476_AT2 and 516_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 9551_AT2 and 522_AT3) or (4905_AT1 and 9551_AT1 and 515_AT3 and 10476_AT2 and 516_AT2 and 521_AT1 and 10632_AT1 and 522_AT4) or (4905_AT1 and 516_AT1 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 522_AT3) or (4905_AT1 and 516_AT1 and 515_AT3 and 522_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT2) or (518_AT3 and 4905_AT1 and 9551_AT1 and 522_AT2 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1) or (4905_AT1 and 521_AT1 and 518_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 522_AT3) or (4905_AT1 and 516_AT1 and 515_AT3 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 522_AT5) or (4905_AT1 and 515_AT3 and 516_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 522_AT4 and 9551_AT2) or (518_AT3 and 4905_AT1 and 9551_AT1 and 515_AT2 and 522_AT1 and 521_AT1 and 10632_AT1 and 10476_AT1) or (4905_AT1 and 515_AT3 and 522_AT1 and 521_AT1 and 518_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3) or (4905_AT1 and 515_AT3 and 522_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 517_AT2 and 9551_AT3) or (518_AT3 and 4905_AT1 and 515_AT2 and 10476_AT2 and 522_AT1 and 521_AT1 and 10632_AT1 and 9551_AT2) or (517_AT1 and 4905_AT1 and 9551_AT1 and 522_AT2 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1) or (517_AT1 and 4905_AT1 and 522_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT2) or (4905_AT1 and 9551_AT1 and 515_AT3 and 10476_AT2 and 521_AT1 and 518_AT1 and 10632_AT1 and 522_AT4) or (4905_AT1 and 515_AT3 and 516_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 522_AT5) or (517_AT1 and 4905_AT1 and 515_AT3 and 10476_AT2 and 521_AT1 and 10632_AT1 and 522_AT5 and 9551_AT2) or (4905_AT1 and 9551_AT1 and 515_AT2 and 522_AT1 and 516_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1) or (4905_AT1 and 516_AT1 and 9551_AT1 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 522_AT3) or (4905_AT1 and 9551_AT1 and 522_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 517_AT2) or (518_AT3 and 4905_AT1 and 515_AT3 and 10476_AT2 and 521_AT1 and 10632_AT1 and 522_AT4 and 9551_AT2) or (4905_AT1 and 9551_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 517_AT2 and 522_AT3) or (4905_AT1 and 515_AT2 and 10476_AT2 and 516_AT2 and 521_AT1 and 10632_AT1 and 9551_AT3 and 522_AT4) or (4905_AT1 and 9551_AT1 and 515_AT2 and 521_AT1 and 518_AT1 and 10632_AT1 and 10476_AT1 and 522_AT3) or (4905_AT1 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 517_AT2 and 9551_AT3 and 522_AT3) or (4905_AT1 and 10476_AT2 and 522_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 517_AT2 and 9551_AT3) or (517_AT1 and 4905_AT1 and 515_AT3 and 522_AT1 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT2) or (4905_AT1 and 515_AT3 and 522_AT2 and 521_AT1 and 518_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3) or (4905_AT1 and 9551_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 518_AT2 and 522_AT3) or (517_AT1 and 4905_AT1 and 522_AT2 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT2) or (4905_AT1 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 522_AT5 and 518_AT2 and 9551_AT2) or (4905_AT1 and 522_AT2 and 515_AT2 and 521_AT1 and 518_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3) or (4905_AT1 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 518_AT2 and 9551_AT2 and 522_AT3) or (4905_AT1 and 10476_AT2 and 516_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 522_AT4 and 9551_AT2) or (4905_AT1 and 515_AT3 and 522_AT2 and 521_AT1 and 518_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT2) or (4905_AT1 and 515_AT3 and 522_AT1 and 521_AT1 and 10632_AT1 and 10476_AT1 and 517_AT2 and 9551_AT2) or (518_AT3 and 4905_AT1 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 9551_AT3 and 522_AT5) or (4905_AT1 and 516_AT1 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 522_AT5 and 9551_AT2) or (517_AT1 and 4905_AT1 and 522_AT2 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 9551_AT2) or (4905_AT1 and 522_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 518_AT2) or (4905_AT1 and 515_AT2 and 10476_AT2 and 516_AT2 and 521_AT1 and 10632_AT1 and 522_AT4 and 9551_AT2) or (518_AT3 and 4905_AT1 and 9551_AT1 and 515_AT3 and 522_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1) or (4905_AT1 and 515_AT3 and 521_AT1 and 10632_AT1 and 10476_AT1 and 522_AT5 and 518_AT2 and 9551_AT2) or (4905_AT1 and 516_AT1 and 522_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3) or (4905_AT1 and 9551_AT1 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 517_AT2 and 522_AT3) or (4905_AT1 and 515_AT3 and 521_AT1 and 10632_AT1 and 10476_AT1 and 517_AT2 and 9551_AT3 and 522_AT3) or (4905_AT1 and 9551_AT1 and 515_AT3 and 522_AT2 and 516_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1) or (517_AT1 and 4905_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT2 and 522_AT3) or (4905_AT1 and 516_AT1 and 9551_AT1 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 522_AT5) or (4905_AT1 and 522_AT2 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 517_AT2 and 9551_AT3) or (4905_AT1 and 515_AT2 and 522_AT1 and 521_AT1 and 10632_AT1 and 10476_AT1 and 517_AT2 and 9551_AT3) or (518_AT3 and 4905_AT1 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 522_AT5 and 9551_AT2) or (4905_AT1 and 516_AT1 and 515_AT3 and 522_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 9551_AT2) or (4905_AT1 and 516_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 522_AT3) or (518_AT3 and 4905_AT1 and 9551_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 522_AT5) or (4905_AT1 and 515_AT3 and 10476_AT2 and 521_AT1 and 10632_AT1 and 517_AT2 and 9551_AT3 and 522_AT3) or (518_AT3 and 4905_AT1 and 522_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3) or (4905_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 518_AT2 and 9551_AT2 and 522_AT3) or (4905_AT1 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 522_AT4 and 518_AT2 and 9551_AT2) or (4905_AT1 and 521_AT1 and 518_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 522_AT5 and 9551_AT2) or (4905_AT1 and 9551_AT1 and 515_AT3 and 521_AT1 and 518_AT1 and 10632_AT1 and 10476_AT1 and 522_AT5) or (4905_AT1 and 515_AT3 and 10476_AT2 and 521_AT1 and 10632_AT1 and 9551_AT3 and 522_AT5 and 518_AT2) or (4905_AT1 and 9551_AT1 and 515_AT3 and 10476_AT2 and 522_AT1 and 521_AT1 and 10632_AT1 and 517_AT2) or (4905_AT1 and 516_AT1 and 9551_AT1 and 522_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1) or (4905_AT1 and 515_AT2 and 10476_AT2 and 522_AT1 and 516_AT2 and 521_AT1 and 10632_AT1 and 9551_AT2) or (4905_AT1 and 516_AT1 and 515_AT3 and 521_AT1 and 10632_AT1 and 10476_AT1 and 522_AT4 and 9551_AT2) or (4905_AT1 and 9551_AT1 and 522_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 517_AT2) or (4905_AT1 and 516_AT1 and 515_AT3 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT2 and 522_AT3) or (4905_AT1 and 515_AT2 and 10476_AT2 and 522_AT1 and 521_AT1 and 518_AT1 and 10632_AT1 and 9551_AT2) or (4905_AT1 and 10476_AT2 and 521_AT1 and 518_AT1 and 515_AT1 and 10632_AT1 and 9551_AT3 and 522_AT4) or (4905_AT1 and 516_AT1 and 9551_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 522_AT5) or (4905_AT1 and 515_AT3 and 522_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 9551_AT3 and 518_AT2) or (4905_AT1 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 517_AT2 and 9551_AT2 and 522_AT3) or (4905_AT1 and 10476_AT2 and 521_AT1 and 518_AT1 and 515_AT1 and 10632_AT1 and 522_AT4 and 9551_AT2) or (4905_AT1 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 518_AT2 and 522_AT3) or (518_AT3 and 4905_AT1 and 515_AT2 and 522_AT1 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3) or (4905_AT1 and 515_AT3 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 522_AT4 and 518_AT2) or (517_AT1 and 4905_AT1 and 9551_AT1 and 10476_AT2 and 522_AT1 and 521_AT1 and 515_AT1 and 10632_AT1) or (4905_AT1 and 9551_AT1 and 515_AT3 and 521_AT1 and 10632_AT1 and 10476_AT1 and 522_AT4 and 518_AT2) or (4905_AT1 and 515_AT2 and 10476_AT2 and 521_AT1 and 518_AT1 and 10632_AT1 and 9551_AT3 and 522_AT5) or (518_AT3 and 4905_AT1 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 522_AT3) or (4905_AT1 and 9551_AT1 and 522_AT1 and 516_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1) or (4905_AT1 and 515_AT2 and 516_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 522_AT5) or (4905_AT1 and 515_AT3 and 10476_AT2 and 516_AT2 and 521_AT1 and 10632_AT1 and 522_AT5 and 9551_AT2) or (4905_AT1 and 515_AT2 and 522_AT1 and 516_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3) or (517_AT1 and 4905_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 522_AT4) or (4905_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 518_AT2 and 522_AT3) or (4905_AT1 and 9551_AT1 and 515_AT3 and 521_AT1 and 10632_AT1 and 10476_AT1 and 517_AT2 and 522_AT3) or (4905_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 517_AT2 and 9551_AT3 and 522_AT3) or (4905_AT1 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 522_AT5 and 518_AT2 and 9551_AT2) or (517_AT1 and 4905_AT1 and 515_AT2 and 522_AT1 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT2) or (518_AT3 and 4905_AT1 and 9551_AT1 and 515_AT3 and 521_AT1 and 10632_AT1 and 10476_AT1 and 522_AT3) or (518_AT3 and 4905_AT1 and 522_AT2 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 9551_AT3) or (4905_AT1 and 10476_AT2 and 521_AT1 and 518_AT1 and 515_AT1 and 10632_AT1 and 9551_AT2 and 522_AT3) or (517_AT1 and 4905_AT1 and 515_AT3 and 522_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 9551_AT2) or (4905_AT1 and 516_AT1 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 9551_AT3 and 522_AT3) or (518_AT3 and 4905_AT1 and 9551_AT1 and 515_AT3 and 10476_AT2 and 521_AT1 and 10632_AT1 and 522_AT5) or (4905_AT1 and 9551_AT1 and 515_AT3 and 10476_AT2 and 521_AT1 and 10632_AT1 and 517_AT2 and 522_AT5) or (4905_AT1 and 516_AT1 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 9551_AT3 and 522_AT5) or (4905_AT1 and 516_AT1 and 9551_AT1 and 515_AT2 and 10476_AT2 and 522_AT1 and 521_AT1 and 10632_AT1) or (4905_AT1 and 516_AT1 and 9551_AT1 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 522_AT5) or (518_AT3 and 4905_AT1 and 9551_AT1 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 522_AT5) or (517_AT1 and 4905_AT1 and 515_AT3 and 522_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 9551_AT3) or (518_AT3 and 4905_AT1 and 515_AT3 and 10476_AT2 and 521_AT1 and 10632_AT1 and 9551_AT2 and 522_AT3) or (4905_AT1 and 10476_AT2 and 516_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 9551_AT3 and 522_AT5) or (4905_AT1 and 516_AT1 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 522_AT4 and 9551_AT2) or (4905_AT1 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 517_AT2 and 522_AT4 and 9551_AT2) or (4905_AT1 and 10476_AT2 and 521_AT1 and 518_AT1 and 515_AT1 and 10632_AT1 and 522_AT5 and 9551_AT2) or (517_AT1 and 4905_AT1 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 9551_AT3 and 522_AT3) or (4905_AT1 and 9551_AT1 and 522_AT2 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 517_AT2) or (4905_AT1 and 515_AT3 and 10476_AT2 and 516_AT2 and 521_AT1 and 10632_AT1 and 9551_AT3 and 522_AT3) or (4905_AT1 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 9551_AT3 and 522_AT5 and 518_AT2) or (4905_AT1 and 522_AT2 and 10476_AT2 and 516_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 9551_AT2) or (4905_AT1 and 516_AT1 and 522_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3) or (4905_AT1 and 9551_AT1 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 518_AT2 and 522_AT3) or (4905_AT1 and 516_AT1 and 522_AT2 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT2) or (4905_AT1 and 9551_AT1 and 515_AT3 and 521_AT1 and 10632_AT1 and 10476_AT1 and 517_AT2 and 522_AT5) or (517_AT1 and 4905_AT1 and 515_AT3 and 10476_AT2 and 522_AT1 and 521_AT1 and 10632_AT1 and 9551_AT3) or (4905_AT1 and 516_AT1 and 9551_AT1 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 522_AT4) or (518_AT3 and 4905_AT1 and 515_AT3 and 521_AT1 and 10632_AT1 and 10476_AT1 and 522_AT5 and 9551_AT2) or (4905_AT1 and 515_AT2 and 522_AT1 and 516_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT2) or (518_AT3 and 4905_AT1 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 522_AT4 and 9551_AT2) or (517_AT1 and 4905_AT1 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 9551_AT3 and 522_AT5) or (4905_AT1 and 522_AT2 and 516_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3) or (4905_AT1 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 9551_AT3 and 522_AT4 and 518_AT2) or (4905_AT1 and 522_AT1 and 521_AT1 and 518_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3) or (517_AT1 and 4905_AT1 and 9551_AT1 and 515_AT3 and 521_AT1 and 10632_AT1 and 10476_AT1 and 522_AT3) or (518_AT3 and 4905_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 522_AT4) or (4905_AT1 and 515_AT3 and 10476_AT2 and 522_AT1 and 516_AT2 and 521_AT1 and 10632_AT1 and 9551_AT3) or (4905_AT1 and 515_AT3 and 522_AT1 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 518_AT2) or (4905_AT1 and 516_AT1 and 515_AT3 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 522_AT3) or (517_AT1 and 4905_AT1 and 9551_AT1 and 515_AT2 and 522_AT1 and 521_AT1 and 10632_AT1 and 10476_AT1) or (4905_AT1 and 9551_AT1 and 515_AT3 and 521_AT1 and 10632_AT1 and 10476_AT1 and 517_AT2 and 522_AT4) or (4905_AT1 and 9551_AT1 and 515_AT3 and 522_AT2 and 10476_AT2 and 516_AT2 and 521_AT1 and 10632_AT1) or (4905_AT1 and 516_AT1 and 515_AT2 and 10476_AT2 and 522_AT1 and 521_AT1 and 10632_AT1 and 9551_AT2) or (4905_AT1 and 515_AT2 and 521_AT1 and 518_AT1 and 10632_AT1 and 10476_AT1 and 522_AT4 and 9551_AT2) or (518_AT3 and 4905_AT1 and 515_AT3 and 522_AT1 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3) or (4905_AT1 and 522_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 517_AT2 and 9551_AT2) or (4905_AT1 and 516_AT1 and 9551_AT1 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 522_AT5) or (4905_AT1 and 516_AT1 and 9551_AT1 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 522_AT4) or (4905_AT1 and 522_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 517_AT2 and 9551_AT3) or (4905_AT1 and 515_AT2 and 522_AT1 and 521_AT1 and 518_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3) or (518_AT3 and 4905_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 522_AT3) or (517_AT1 and 4905_AT1 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 522_AT5 and 9551_AT2) or (4905_AT1 and 9551_AT1 and 515_AT3 and 10476_AT2 and 522_AT1 and 516_AT2 and 521_AT1 and 10632_AT1) or (4905_AT1 and 9551_AT1 and 10476_AT2 and 522_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 518_AT2) or (4905_AT1 and 9551_AT1 and 515_AT3 and 521_AT1 and 518_AT1 and 10632_AT1 and 10476_AT1 and 522_AT4) or (4905_AT1 and 515_AT3 and 521_AT1 and 10632_AT1 and 10476_AT1 and 517_AT2 and 9551_AT3 and 522_AT5) or (4905_AT1 and 9551_AT1 and 516_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 522_AT5) or (4905_AT1 and 9551_AT1 and 515_AT3 and 521_AT1 and 10632_AT1 and 10476_AT1 and 518_AT2 and 522_AT3) or (518_AT3 and 4905_AT1 and 522_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT2) or (518_AT3 and 4905_AT1 and 9551_AT1 and 515_AT3 and 521_AT1 and 10632_AT1 and 10476_AT1 and 522_AT4) or (517_AT1 and 4905_AT1 and 9551_AT1 and 522_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1) or (518_AT3 and 4905_AT1 and 515_AT3 and 10476_AT2 and 522_AT1 and 521_AT1 and 10632_AT1 and 9551_AT3) or (518_AT3 and 4905_AT1 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 9551_AT3 and 522_AT4) or (4905_AT1 and 9551_AT1 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 517_AT2 and 522_AT4) or (4905_AT1 and 515_AT3 and 10476_AT2 and 522_AT1 and 521_AT1 and 518_AT1 and 10632_AT1 and 9551_AT2) or (4905_AT1 and 9551_AT1 and 515_AT2 and 522_AT1 and 521_AT1 and 518_AT1 and 10632_AT1 and 10476_AT1) or (517_AT1 and 4905_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 522_AT5) or (4905_AT1 and 515_AT3 and 521_AT1 and 518_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 522_AT4) or (4905_AT1 and 9551_AT1 and 515_AT2 and 10476_AT2 and 522_AT1 and 516_AT2 and 521_AT1 and 10632_AT1) or (517_AT1 and 4905_AT1 and 515_AT3 and 10476_AT2 and 522_AT1 and 521_AT1 and 10632_AT1 and 9551_AT2) or (4905_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 517_AT2 and 522_AT5 and 9551_AT2) or (4905_AT1 and 516_AT1 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT2 and 522_AT3) or (517_AT1 and 4905_AT1 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 522_AT4 and 9551_AT2) or (4905_AT1 and 9551_AT1 and 515_AT3 and 10476_AT2 and 521_AT1 and 10632_AT1 and 517_AT2 and 522_AT4) or (518_AT3 and 4905_AT1 and 522_AT2 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 9551_AT3) or (4905_AT1 and 516_AT1 and 515_AT3 and 10476_AT2 and 522_AT1 and 521_AT1 and 10632_AT1 and 9551_AT2) or (4905_AT1 and 516_AT1 and 9551_AT1 and 515_AT3 and 522_AT1 and 521_AT1 and 10632_AT1 and 10476_AT1) or (4905_AT1 and 516_AT1 and 515_AT3 and 10476_AT2 and 522_AT1 and 521_AT1 and 10632_AT1 and 9551_AT3) or (4905_AT1 and 515_AT3 and 516_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 522_AT5 and 9551_AT2) or (4905_AT1 and 515_AT2 and 521_AT1 and 518_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 522_AT4) or (517_AT1 and 4905_AT1 and 9551_AT1 and 515_AT3 and 10476_AT2 and 522_AT1 and 521_AT1 and 10632_AT1) or (4905_AT1 and 522_AT2 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 517_AT2 and 9551_AT2) or (4905_AT1 and 516_AT1 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 9551_AT3 and 522_AT4) or (4905_AT1 and 515_AT3 and 521_AT1 and 10632_AT1 and 10476_AT1 and 517_AT2 and 9551_AT2 and 522_AT3) or (518_AT3 and 4905_AT1 and 9551_AT1 and 515_AT3 and 521_AT1 and 10632_AT1 and 10476_AT1 and 522_AT5) or (4905_AT1 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 9551_AT3 and 518_AT2 and 522_AT3) or (517_AT1 and 4905_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 522_AT4 and 9551_AT2) or (517_AT1 and 4905_AT1 and 515_AT3 and 10476_AT2 and 521_AT1 and 10632_AT1 and 9551_AT3 and 522_AT3) or (4905_AT1 and 9551_AT1 and 515_AT2 and 10476_AT2 and 522_AT1 and 521_AT1 and 10632_AT1 and 518_AT2) or (4905_AT1 and 515_AT3 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 518_AT2 and 522_AT3) or (517_AT1 and 4905_AT1 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 9551_AT3 and 522_AT5) or (4905_AT1 and 522_AT2 and 10476_AT2 and 521_AT1 and 518_AT1 and 515_AT1 and 10632_AT1 and 9551_AT2) or (517_AT1 and 4905_AT1 and 9551_AT1 and 522_AT2 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1) or (4905_AT1 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 517_AT2 and 522_AT5 and 9551_AT2) or (4905_AT1 and 516_AT1 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 522_AT5 and 9551_AT2) or (517_AT1 and 4905_AT1 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 9551_AT3 and 522_AT4) or (4905_AT1 and 515_AT2 and 10476_AT2 and 522_AT1 and 521_AT1 and 10632_AT1 and 518_AT2 and 9551_AT2) or (4905_AT1 and 9551_AT1 and 515_AT3 and 522_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 517_AT2) or (4905_AT1 and 9551_AT1 and 10476_AT2 and 522_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 517_AT2) or (4905_AT1 and 10476_AT2 and 522_AT1 and 516_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 9551_AT2) or (518_AT3 and 4905_AT1 and 9551_AT1 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 522_AT3) or (4905_AT1 and 516_AT1 and 522_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT2) or (4905_AT1 and 516_AT1 and 9551_AT1 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 522_AT3) or (4905_AT1 and 522_AT2 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 517_AT2 and 9551_AT2) or (4905_AT1 and 9551_AT1 and 515_AT2 and 10476_AT2 and 522_AT1 and 521_AT1 and 518_AT1 and 10632_AT1) or (517_AT1 and 4905_AT1 and 9551_AT1 and 515_AT3 and 521_AT1 and 10632_AT1 and 10476_AT1 and 522_AT4) or (4905_AT1 and 9551_AT1 and 515_AT2 and 10476_AT2 and 521_AT1 and 518_AT1 and 10632_AT1 and 522_AT3) or (517_AT1 and 4905_AT1 and 515_AT3 and 10476_AT2 and 521_AT1 and 10632_AT1 and 9551_AT3 and 522_AT5) or (518_AT3 and 4905_AT1 and 9551_AT1 and 515_AT3 and 10476_AT2 and 521_AT1 and 10632_AT1 and 522_AT4) or (4905_AT1 and 10476_AT2 and 522_AT1 and 521_AT1 and 518_AT1 and 515_AT1 and 10632_AT1 and 9551_AT2) or (4905_AT1 and 515_AT3 and 522_AT2 and 10476_AT2 and 521_AT1 and 518_AT1 and 10632_AT1 and 9551_AT3) or (4905_AT1 and 9551_AT1 and 515_AT3 and 516_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 522_AT4) or (4905_AT1 and 9551_AT1 and 515_AT3 and 10476_AT2 and 516_AT2 and 521_AT1 and 10632_AT1 and 522_AT3) or (4905_AT1 and 9551_AT1 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 522_AT5 and 518_AT2) or (4905_AT1 and 522_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 517_AT2 and 9551_AT2) or (4905_AT1 and 516_AT1 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 9551_AT3 and 522_AT4) or (517_AT1 and 4905_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 522_AT5 and 9551_AT2) or (4905_AT1 and 515_AT2 and 10476_AT2 and 522_AT1 and 521_AT1 and 10632_AT1 and 517_AT2 and 9551_AT3) or (4905_AT1 and 9551_AT1 and 522_AT2 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 517_AT2) or (518_AT3 and 4905_AT1 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 9551_AT3 and 522_AT4) or (517_AT1 and 4905_AT1 and 9551_AT1 and 522_AT2 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1) or (4905_AT1 and 515_AT3 and 10476_AT2 and 521_AT1 and 10632_AT1 and 9551_AT3 and 518_AT2 and 522_AT3) or (517_AT1 and 4905_AT1 and 515_AT2 and 10476_AT2 and 522_AT1 and 521_AT1 and 10632_AT1 and 9551_AT3) or (4905_AT1 and 9551_AT1 and 522_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 518_AT2) or (4905_AT1 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 522_AT4 and 518_AT2 and 9551_AT2) or (4905_AT1 and 9551_AT1 and 515_AT3 and 521_AT1 and 518_AT1 and 10632_AT1 and 10476_AT1 and 522_AT3) or (4905_AT1 and 9551_AT1 and 515_AT3 and 522_AT2 and 521_AT1 and 518_AT1 and 10632_AT1 and 10476_AT1) or (518_AT3 and 4905_AT1 and 515_AT3 and 10476_AT2 and 521_AT1 and 10632_AT1 and 522_AT5 and 9551_AT2) or (518_AT3 and 4905_AT1 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 522_AT5) or (4905_AT1 and 515_AT2 and 10476_AT2 and 516_AT2 and 521_AT1 and 10632_AT1 and 9551_AT2 and 522_AT3) or (4905_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 522_AT4 and 518_AT2 and 9551_AT2) or (4905_AT1 and 10476_AT2 and 522_AT1 and 521_AT1 and 518_AT1 and 515_AT1 and 10632_AT1 and 9551_AT3) or (4905_AT1 and 9551_AT1 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 522_AT4 and 518_AT2) or (4905_AT1 and 522_AT1 and 521_AT1 and 518_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT2) or (4905_AT1 and 515_AT2 and 10476_AT2 and 521_AT1 and 518_AT1 and 10632_AT1 and 9551_AT3 and 522_AT3) or (517_AT1 and 4905_AT1 and 515_AT3 and 522_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3) or (4905_AT1 and 522_AT2 and 515_AT2 and 10476_AT2 and 516_AT2 and 521_AT1 and 10632_AT1 and 9551_AT2) or (518_AT3 and 4905_AT1 and 10476_AT2 and 522_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 9551_AT3) or (517_AT1 and 4905_AT1 and 522_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3) or (4905_AT1 and 515_AT3 and 521_AT1 and 10632_AT1 and 10476_AT1 and 518_AT2 and 9551_AT2 and 522_AT3) or (4905_AT1 and 9551_AT1 and 515_AT3 and 522_AT1 and 521_AT1 and 10632_AT1 and 10476_AT1 and 518_AT2) or (4905_AT1 and 515_AT3 and 10476_AT2 and 522_AT1 and 521_AT1 and 10632_AT1 and 517_AT2 and 9551_AT2) or (4905_AT1 and 515_AT3 and 521_AT1 and 10632_AT1 and 10476_AT1 and 517_AT2 and 9551_AT3 and 522_AT4) or (518_AT3 and 4905_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT2 and 522_AT3) or (4905_AT1 and 9551_AT1 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 517_AT2 and 522_AT3) or (4905_AT1 and 515_AT2 and 10476_AT2 and 522_AT1 and 516_AT2 and 521_AT1 and 10632_AT1 and 9551_AT3) or (517_AT1 and 4905_AT1 and 9551_AT1 and 515_AT3 and 10476_AT2 and 521_AT1 and 10632_AT1 and 522_AT5) or (518_AT3 and 4905_AT1 and 515_AT3 and 522_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3) or (518_AT3 and 4905_AT1 and 9551_AT1 and 522_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1) or (4905_AT1 and 515_AT2 and 516_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT2 and 522_AT3) or (4905_AT1 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 517_AT2 and 9551_AT3 and 522_AT5) or (4905_AT1 and 516_AT1 and 515_AT3 and 522_AT1 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3) or (518_AT3 and 4905_AT1 and 9551_AT1 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 522_AT5) or (4905_AT1 and 516_AT1 and 9551_AT1 and 515_AT3 and 522_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1) or (4905_AT1 and 9551_AT1 and 515_AT2 and 516_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 522_AT5) or (4905_AT1 and 521_AT1 and 518_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 522_AT4 and 9551_AT2) or (517_AT1 and 4905_AT1 and 515_AT2 and 10476_AT2 and 522_AT1 and 521_AT1 and 10632_AT1 and 9551_AT2) or (4905_AT1 and 516_AT1 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 522_AT4 and 9551_AT2) or (4905_AT1 and 9551_AT1 and 515_AT3 and 10476_AT2 and 521_AT1 and 518_AT1 and 10632_AT1 and 522_AT3) or (4905_AT1 and 515_AT3 and 10476_AT2 and 521_AT1 and 518_AT1 and 10632_AT1 and 522_AT5 and 9551_AT2) or (4905_AT1 and 516_AT1 and 515_AT3 and 10476_AT2 and 521_AT1 and 10632_AT1 and 522_AT5 and 9551_AT2) or (518_AT3 and 4905_AT1 and 515_AT3 and 522_AT1 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT2) or (4905_AT1 and 516_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 522_AT4 and 9551_AT2) or (4905_AT1 and 516_AT1 and 515_AT3 and 10476_AT2 and 521_AT1 and 10632_AT1 and 9551_AT3 and 522_AT5) or (518_AT3 and 4905_AT1 and 9551_AT1 and 10476_AT2 and 522_AT1 and 521_AT1 and 515_AT1 and 10632_AT1) or (4905_AT1 and 515_AT3 and 522_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 518_AT2 and 9551_AT2) or (4905_AT1 and 522_AT1 and 516_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3) or (4905_AT1 and 515_AT2 and 521_AT1 and 518_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT2 and 522_AT3) or (4905_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 517_AT2 and 9551_AT3 and 522_AT5) or (4905_AT1 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 517_AT2 and 9551_AT3 and 522_AT3) or (4905_AT1 and 9551_AT1 and 515_AT3 and 10476_AT2 and 522_AT1 and 521_AT1 and 10632_AT1 and 518_AT2) or (4905_AT1 and 515_AT3 and 522_AT1 and 521_AT1 and 10632_AT1 and 10476_AT1 and 517_AT2 and 9551_AT3) or (517_AT1 and 4905_AT1 and 9551_AT1 and 515_AT2 and 10476_AT2 and 522_AT1 and 521_AT1 and 10632_AT1) or (4905_AT1 and 9551_AT1 and 515_AT2 and 10476_AT2 and 516_AT2 and 521_AT1 and 10632_AT1 and 522_AT4) or (4905_AT1 and 9551_AT1 and 522_AT2 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 517_AT2) or (4905_AT1 and 516_AT1 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 522_AT4 and 9551_AT2) or (4905_AT1 and 516_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 522_AT5 and 9551_AT2) or (4905_AT1 and 516_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 522_AT5 and 9551_AT2) or (4905_AT1 and 516_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT2 and 522_AT3) or (4905_AT1 and 516_AT1 and 522_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT2) or (517_AT1 and 4905_AT1 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 522_AT4 and 9551_AT2) or (4905_AT1 and 9551_AT1 and 515_AT3 and 516_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 522_AT3) or (4905_AT1 and 10476_AT2 and 521_AT1 and 518_AT1 and 515_AT1 and 10632_AT1 and 9551_AT3 and 522_AT5) or (4905_AT1 and 9551_AT1 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 522_AT5 and 518_AT2) or (517_AT1 and 4905_AT1 and 515_AT3 and 522_AT1 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3) or (4905_AT1 and 515_AT3 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 522_AT5 and 518_AT2) or (4905_AT1 and 522_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 518_AT2 and 9551_AT2) or (517_AT1 and 4905_AT1 and 9551_AT1 and 515_AT3 and 522_AT1 and 521_AT1 and 10632_AT1 and 10476_AT1) or (518_AT3 and 4905_AT1 and 9551_AT1 and 515_AT2 and 10476_AT2 and 522_AT1 and 521_AT1 and 10632_AT1) or (4905_AT1 and 515_AT3 and 521_AT1 and 518_AT1 and 10632_AT1 and 10476_AT1 and 522_AT5 and 9551_AT2) or (518_AT3 and 4905_AT1 and 515_AT3 and 10476_AT2 and 521_AT1 and 10632_AT1 and 9551_AT3 and 522_AT3) or (518_AT3 and 4905_AT1 and 9551_AT1 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 522_AT4) or (517_AT1 and 4905_AT1 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 9551_AT3 and 522_AT3) or (4905_AT1 and 515_AT2 and 10476_AT2 and 516_AT2 and 521_AT1 and 10632_AT1 and 522_AT5 and 9551_AT2) or (4905_AT1 and 9551_AT1 and 10476_AT2 and 521_AT1 and 518_AT1 and 515_AT1 and 10632_AT1 and 522_AT5) or (4905_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 517_AT2 and 9551_AT2 and 522_AT3) or (4905_AT1 and 522_AT2 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 518_AT2 and 9551_AT2) or (4905_AT1 and 515_AT3 and 522_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 517_AT2 and 9551_AT2) or (518_AT3 and 4905_AT1 and 9551_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 522_AT4) or (4905_AT1 and 516_AT1 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 9551_AT3 and 522_AT3) or (518_AT3 and 4905_AT1 and 522_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3) or (518_AT3 and 4905_AT1 and 9551_AT1 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 522_AT3) or (517_AT1 and 4905_AT1 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT2 and 522_AT3) or (4905_AT1 and 9551_AT1 and 10476_AT2 and 521_AT1 and 518_AT1 and 515_AT1 and 10632_AT1 and 522_AT4) or (4905_AT1 and 9551_AT1 and 10476_AT2 and 516_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 522_AT5) or (4905_AT1 and 9551_AT1 and 10476_AT2 and 516_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 522_AT4) or (4905_AT1 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 9551_AT3 and 518_AT2 and 522_AT3) or (4905_AT1 and 9551_AT1 and 522_AT2 and 515_AT2 and 521_AT1 and 518_AT1 and 10632_AT1 and 10476_AT1) or (4905_AT1 and 515_AT2 and 521_AT1 and 518_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 522_AT3) or (4905_AT1 and 515_AT3 and 521_AT1 and 518_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 522_AT3) or (4905_AT1 and 515_AT3 and 10476_AT2 and 516_AT2 and 521_AT1 and 10632_AT1 and 9551_AT3 and 522_AT5) or (4905_AT1 and 516_AT1 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 522_AT5 and 9551_AT2) or (517_AT1 and 4905_AT1 and 9551_AT1 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 522_AT4) or (4905_AT1 and 515_AT2 and 10476_AT2 and 521_AT1 and 518_AT1 and 10632_AT1 and 9551_AT3 and 522_AT4) or (4905_AT1 and 522_AT2 and 515_AT2 and 516_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3) or (4905_AT1 and 515_AT3 and 10476_AT2 and 522_AT1 and 521_AT1 and 518_AT1 and 10632_AT1 and 9551_AT3) or (4905_AT1 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 517_AT2 and 9551_AT3 and 522_AT4) or (4905_AT1 and 9551_AT1 and 515_AT3 and 10476_AT2 and 521_AT1 and 10632_AT1 and 522_AT4 and 518_AT2) or (517_AT1 and 4905_AT1 and 9551_AT1 and 522_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1) or (4905_AT1 and 522_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 517_AT2 and 9551_AT3) or (4905_AT1 and 515_AT3 and 10476_AT2 and 516_AT2 and 521_AT1 and 10632_AT1 and 9551_AT2 and 522_AT3) or (4905_AT1 and 9551_AT1 and 515_AT2 and 10476_AT2 and 522_AT1 and 521_AT1 and 10632_AT1 and 517_AT2) or (4905_AT1 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 522_AT4 and 518_AT2) or (518_AT3 and 4905_AT1 and 10476_AT2 and 522_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 9551_AT2) or (4905_AT1 and 9551_AT1 and 515_AT3 and 10476_AT2 and 522_AT1 and 521_AT1 and 518_AT1 and 10632_AT1) or (4905_AT1 and 9551_AT1 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 517_AT2 and 522_AT4) or (4905_AT1 and 516_AT1 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 9551_AT3 and 522_AT5) or (517_AT1 and 4905_AT1 and 515_AT2 and 522_AT1 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3) or (4905_AT1 and 515_AT3 and 521_AT1 and 10632_AT1 and 10476_AT1 and 522_AT4 and 518_AT2 and 9551_AT2) or (517_AT1 and 4905_AT1 and 515_AT3 and 521_AT1 and 10632_AT1 and 10476_AT1 and 522_AT5 and 9551_AT2) or (518_AT3 and 4905_AT1 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 9551_AT2 and 522_AT3) or (4905_AT1 and 516_AT1 and 515_AT3 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 522_AT4) or (4905_AT1 and 516_AT1 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 522_AT5) or (4905_AT1 and 516_AT1 and 515_AT3 and 10476_AT2 and 521_AT1 and 10632_AT1 and 9551_AT3 and 522_AT4) or (4905_AT1 and 515_AT3 and 521_AT1 and 10632_AT1 and 10476_AT1 and 517_AT2 and 522_AT5 and 9551_AT2) or (4905_AT1 and 515_AT3 and 522_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 517_AT2 and 9551_AT2) or (518_AT3 and 4905_AT1 and 9551_AT1 and 522_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1) or (518_AT3 and 4905_AT1 and 515_AT3 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 522_AT4) or (4905_AT1 and 522_AT2 and 515_AT2 and 521_AT1 and 518_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT2) or (517_AT1 and 4905_AT1 and 522_AT2 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 9551_AT3) or (4905_AT1 and 9551_AT1 and 10476_AT2 and 516_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 522_AT3) or (4905_AT1 and 516_AT1 and 9551_AT1 and 522_AT2 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1) or (4905_AT1 and 522_AT2 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 517_AT2 and 9551_AT3) or (4905_AT1 and 516_AT1 and 9551_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 522_AT4) or (4905_AT1 and 522_AT2 and 515_AT2 and 516_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT2) or (4905_AT1 and 516_AT1 and 9551_AT1 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 522_AT4) or (518_AT3 and 4905_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 522_AT4 and 9551_AT2) or (518_AT3 and 4905_AT1 and 515_AT3 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 522_AT3) or (4905_AT1 and 522_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 518_AT2 and 9551_AT2) or (4905_AT1 and 515_AT3 and 10476_AT2 and 521_AT1 and 518_AT1 and 10632_AT1 and 9551_AT3 and 522_AT3) or (4905_AT1 and 9551_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 517_AT2 and 522_AT4) or (4905_AT1 and 516_AT1 and 9551_AT1 and 515_AT3 and 521_AT1 and 10632_AT1 and 10476_AT1 and 522_AT3) or (4905_AT1 and 516_AT1 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 9551_AT2 and 522_AT3) or (4905_AT1 and 521_AT1 and 518_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT2 and 522_AT3) or (518_AT3 and 4905_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 522_AT5) or (517_AT1 and 4905_AT1 and 9551_AT1 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 522_AT5) or (4905_AT1 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 517_AT2 and 522_AT5 and 9551_AT2) or (4905_AT1 and 9551_AT1 and 522_AT2 and 516_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1) or (4905_AT1 and 516_AT1 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 9551_AT2 and 522_AT3) or (4905_AT1 and 9551_AT1 and 521_AT1 and 518_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 522_AT4) or (4905_AT1 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 517_AT2 and 522_AT4 and 9551_AT2) or (518_AT3 and 4905_AT1 and 515_AT3 and 522_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 9551_AT3) or (4905_AT1 and 516_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT2 and 522_AT3) or (518_AT3 and 4905_AT1 and 515_AT2 and 10476_AT2 and 522_AT1 and 521_AT1 and 10632_AT1 and 9551_AT3) or (517_AT1 and 4905_AT1 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 522_AT5 and 9551_AT2) or (4905_AT1 and 9551_AT1 and 515_AT2 and 521_AT1 and 518_AT1 and 10632_AT1 and 10476_AT1 and 522_AT5) or (4905_AT1 and 9551_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 517_AT2 and 522_AT5) or (517_AT1 and 4905_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 522_AT3) or (4905_AT1 and 515_AT2 and 516_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 522_AT4) or (4905_AT1 and 515_AT2 and 10476_AT2 and 522_AT1 and 521_AT1 and 10632_AT1 and 9551_AT3 and 518_AT2) or (4905_AT1 and 515_AT3 and 521_AT1 and 518_AT1 and 10632_AT1 and 10476_AT1 and 522_AT4 and 9551_AT2) or (517_AT1 and 4905_AT1 and 522_AT2 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 9551_AT3) or (4905_AT1 and 515_AT3 and 10476_AT2 and 521_AT1 and 518_AT1 and 10632_AT1 and 522_AT4 and 9551_AT2) or (517_AT1 and 4905_AT1 and 515_AT3 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 522_AT4) or (517_AT1 and 4905_AT1 and 9551_AT1 and 515_AT3 and 522_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1) or (4905_AT1 and 522_AT2 and 516_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT2) or (4905_AT1 and 516_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 522_AT5) or (4905_AT1 and 516_AT1 and 9551_AT1 and 515_AT3 and 10476_AT2 and 521_AT1 and 10632_AT1 and 522_AT4) or (4905_AT1 and 515_AT3 and 10476_AT2 and 521_AT1 and 10632_AT1 and 522_AT4 and 518_AT2 and 9551_AT2) or (4905_AT1 and 516_AT1 and 515_AT2 and 522_AT1 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3) or (4905_AT1 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 517_AT2 and 522_AT4 and 9551_AT2) or (518_AT3 and 4905_AT1 and 522_AT2 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT2) or (4905_AT1 and 516_AT1 and 515_AT3 and 10476_AT2 and 521_AT1 and 10632_AT1 and 9551_AT3 and 522_AT3) or (4905_AT1 and 515_AT2 and 10476_AT2 and 522_AT1 and 521_AT1 and 518_AT1 and 10632_AT1 and 9551_AT3) or (4905_AT1 and 522_AT2 and 515_AT2 and 10476_AT2 and 516_AT2 and 521_AT1 and 10632_AT1 and 9551_AT3) or (4905_AT1 and 9551_AT1 and 515_AT3 and 522_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 517_AT2) or (4905_AT1 and 522_AT2 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 518_AT2) or (4905_AT1 and 9551_AT1 and 515_AT3 and 522_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 518_AT2) or (4905_AT1 and 10476_AT2 and 522_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 9551_AT3 and 518_AT2) or (4905_AT1 and 9551_AT1 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 517_AT2 and 522_AT5) or (4905_AT1 and 9551_AT1 and 522_AT2 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 518_AT2) or (4905_AT1 and 515_AT3 and 10476_AT2 and 521_AT1 and 10632_AT1 and 517_AT2 and 522_AT5 and 9551_AT2) or (517_AT1 and 4905_AT1 and 9551_AT1 and 515_AT3 and 10476_AT2 and 521_AT1 and 10632_AT1 and 522_AT3) or (518_AT3 and 4905_AT1 and 515_AT3 and 522_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 9551_AT2) or (4905_AT1 and 515_AT2 and 10476_AT2 and 516_AT2 and 521_AT1 and 10632_AT1 and 9551_AT3 and 522_AT3) or (4905_AT1 and 515_AT3 and 522_AT1 and 516_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT2) or (4905_AT1 and 515_AT3 and 10476_AT2 and 521_AT1 and 10632_AT1 and 517_AT2 and 9551_AT3 and 522_AT5) or (4905_AT1 and 9551_AT1 and 515_AT3 and 10476_AT2 and 516_AT2 and 521_AT1 and 10632_AT1 and 522_AT5) or (4905_AT1 and 9551_AT1 and 522_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 518_AT2) or (4905_AT1 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 517_AT2 and 9551_AT3 and 522_AT3) or (4905_AT1 and 515_AT2 and 516_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 522_AT5 and 9551_AT2) or (4905_AT1 and 516_AT1 and 9551_AT1 and 515_AT3 and 10476_AT2 and 521_AT1 and 10632_AT1 and 522_AT3) or (4905_AT1 and 9551_AT1 and 515_AT3 and 10476_AT2 and 521_AT1 and 10632_AT1 and 522_AT5 and 518_AT2) or (4905_AT1 and 515_AT3 and 10476_AT2 and 516_AT2 and 521_AT1 and 10632_AT1 and 9551_AT3 and 522_AT4) or (4905_AT1 and 516_AT1 and 9551_AT1 and 522_AT2 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1) or (4905_AT1 and 515_AT3 and 521_AT1 and 10632_AT1 and 10476_AT1 and 517_AT2 and 522_AT4 and 9551_AT2) or (4905_AT1 and 515_AT3 and 10476_AT2 and 522_AT1 and 521_AT1 and 10632_AT1 and 9551_AT3 and 518_AT2) or (517_AT1 and 4905_AT1 and 522_AT2 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 9551_AT2) or (4905_AT1 and 516_AT1 and 515_AT2 and 10476_AT2 and 522_AT1 and 521_AT1 and 10632_AT1 and 9551_AT3) or (4905_AT1 and 515_AT3 and 10476_AT2 and 521_AT1 and 518_AT1 and 10632_AT1 and 9551_AT3 and 522_AT5) or (4905_AT1 and 515_AT3 and 10476_AT2 and 516_AT2 and 521_AT1 and 10632_AT1 and 522_AT4 and 9551_AT2) or (4905_AT1 and 9551_AT1 and 522_AT1 and 521_AT1 and 518_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1) or (4905_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 517_AT2 and 522_AT4 and 9551_AT2) or (4905_AT1 and 516_AT1 and 9551_AT1 and 522_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1) or (4905_AT1 and 515_AT3 and 10476_AT2 and 521_AT1 and 10632_AT1 and 517_AT2 and 9551_AT2 and 522_AT3) or (4905_AT1 and 9551_AT1 and 522_AT2 and 10476_AT2 and 521_AT1 and 518_AT1 and 515_AT1 and 10632_AT1) or (518_AT3 and 4905_AT1 and 522_AT2 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 9551_AT2) or (4905_AT1 and 515_AT3 and 10476_AT2 and 521_AT1 and 10632_AT1 and 522_AT5 and 518_AT2 and 9551_AT2) or (518_AT3 and 4905_AT1 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 522_AT4 and 9551_AT2) or (4905_AT1 and 516_AT1 and 9551_AT1 and 515_AT2 and 522_AT1 and 521_AT1 and 10632_AT1 and 10476_AT1) or (517_AT1 and 4905_AT1 and 515_AT3 and 521_AT1 and 10632_AT1 and 10476_AT1 and 522_AT4 and 9551_AT2) or (517_AT1 and 4905_AT1 and 9551_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 522_AT3) or (517_AT1 and 4905_AT1 and 515_AT3 and 10476_AT2 and 521_AT1 and 10632_AT1 and 522_AT4 and 9551_AT2) or (4905_AT1 and 9551_AT1 and 522_AT2 and 10476_AT2 and 516_AT2 and 521_AT1 and 515_AT1 and 10632_AT1) or (4905_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 522_AT5 and 518_AT2) or (517_AT1 and 4905_AT1 and 9551_AT1 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 522_AT3) or (517_AT1 and 4905_AT1 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 522_AT5 and 9551_AT2) or (518_AT3 and 4905_AT1 and 515_AT3 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT2 and 522_AT3) or (518_AT3 and 4905_AT1 and 9551_AT1 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 522_AT3) or (4905_AT1 and 515_AT2 and 10476_AT2 and 521_AT1 and 518_AT1 and 10632_AT1 and 522_AT4 and 9551_AT2) or (4905_AT1 and 522_AT2 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 518_AT2 and 9551_AT2) or (517_AT1 and 4905_AT1 and 10476_AT2 and 522_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 9551_AT3) or (4905_AT1 and 515_AT2 and 522_AT1 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 518_AT2) or (4905_AT1 and 9551_AT1 and 515_AT3 and 522_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 518_AT2) or (4905_AT1 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 522_AT4 and 518_AT2 and 9551_AT2) or (4905_AT1 and 9551_AT1 and 515_AT2 and 516_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 522_AT3) or (517_AT1 and 4905_AT1 and 9551_AT1 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 522_AT4) or (4905_AT1 and 515_AT3 and 521_AT1 and 518_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT2 and 522_AT3) or (4905_AT1 and 9551_AT1 and 515_AT3 and 10476_AT2 and 521_AT1 and 10632_AT1 and 517_AT2 and 522_AT3) or (4905_AT1 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 518_AT2 and 9551_AT2 and 522_AT3) or (4905_AT1 and 9551_AT1 and 515_AT2 and 522_AT1 and 521_AT1 and 10632_AT1 and 10476_AT1 and 517_AT2) or (4905_AT1 and 522_AT1 and 516_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT2) or (4905_AT1 and 516_AT1 and 522_AT2 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3) or (4905_AT1 and 9551_AT1 and 10476_AT2 and 522_AT1 and 521_AT1 and 518_AT1 and 515_AT1 and 10632_AT1) or (4905_AT1 and 516_AT1 and 9551_AT1 and 515_AT3 and 521_AT1 and 10632_AT1 and 10476_AT1 and 522_AT4) or (4905_AT1 and 9551_AT1 and 515_AT3 and 522_AT1 and 521_AT1 and 518_AT1 and 10632_AT1 and 10476_AT1) or (4905_AT1 and 10476_AT2 and 522_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 517_AT2 and 9551_AT2) or (517_AT1 and 4905_AT1 and 9551_AT1 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 522_AT3) or (4905_AT1 and 516_AT1 and 9551_AT1 and 515_AT3 and 10476_AT2 and 521_AT1 and 10632_AT1 and 522_AT5) or (518_AT3 and 4905_AT1 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 522_AT4 and 9551_AT2) or (4905_AT1 and 515_AT3 and 521_AT1 and 518_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 522_AT5) or (4905_AT1 and 9551_AT1 and 516_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 522_AT3) or (517_AT1 and 4905_AT1 and 9551_AT1 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 522_AT4) or (4905_AT1 and 9551_AT1 and 521_AT1 and 518_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 522_AT3) or (517_AT1 and 4905_AT1 and 515_AT3 and 10476_AT2 and 521_AT1 and 10632_AT1 and 9551_AT3 and 522_AT4) or (518_AT3 and 4905_AT1 and 515_AT3 and 10476_AT2 and 521_AT1 and 10632_AT1 and 9551_AT3 and 522_AT5) or (518_AT3 and 4905_AT1 and 9551_AT1 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 522_AT4) or (4905_AT1 and 516_AT1 and 522_AT2 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 9551_AT3) or (4905_AT1 and 516_AT1 and 9551_AT1 and 10476_AT2 and 522_AT1 and 521_AT1 and 515_AT1 and 10632_AT1) or (4905_AT1 and 9551_AT1 and 522_AT2 and 515_AT2 and 10476_AT2 and 521_AT1 and 518_AT1 and 10632_AT1) or (4905_AT1 and 516_AT1 and 515_AT2 and 522_AT1 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT2) or (4905_AT1 and 522_AT2 and 515_AT2 and 10476_AT2 and 521_AT1 and 518_AT1 and 10632_AT1 and 9551_AT3) or (4905_AT1 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 517_AT2 and 522_AT5 and 9551_AT2) or (4905_AT1 and 515_AT2 and 521_AT1 and 518_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 522_AT5) or (518_AT3 and 4905_AT1 and 9551_AT1 and 515_AT3 and 10476_AT2 and 522_AT1 and 521_AT1 and 10632_AT1) or (4905_AT1 and 9551_AT1 and 515_AT3 and 522_AT2 and 10476_AT2 and 521_AT1 and 518_AT1 and 10632_AT1) or (4905_AT1 and 9551_AT1 and 515_AT2 and 522_AT1 and 521_AT1 and 10632_AT1 and 10476_AT1 and 518_AT2) or (518_AT3 and 4905_AT1 and 522_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT2) or (4905_AT1 and 515_AT3 and 522_AT2 and 516_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT2) or (4905_AT1 and 9551_AT1 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 522_AT4 and 518_AT2) or (4905_AT1 and 516_AT1 and 515_AT3 and 522_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3) or (4905_AT1 and 515_AT2 and 10476_AT2 and 522_AT1 and 521_AT1 and 10632_AT1 and 517_AT2 and 9551_AT2) or (4905_AT1 and 10476_AT2 and 522_AT1 and 516_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 9551_AT3) or (4905_AT1 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 517_AT2 and 9551_AT3 and 522_AT5) or (517_AT1 and 4905_AT1 and 515_AT3 and 10476_AT2 and 521_AT1 and 10632_AT1 and 9551_AT2 and 522_AT3) or (518_AT3 and 4905_AT1 and 9551_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 522_AT3) or (4905_AT1 and 516_AT1 and 515_AT3 and 522_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 9551_AT3) or (4905_AT1 and 516_AT1 and 9551_AT1 and 515_AT3 and 521_AT1 and 10632_AT1 and 10476_AT1 and 522_AT5) or (4905_AT1 and 515_AT2 and 522_AT1 and 521_AT1 and 10632_AT1 and 10476_AT1 and 518_AT2 and 9551_AT2) or (4905_AT1 and 515_AT3 and 10476_AT2 and 521_AT1 and 10632_AT1 and 517_AT2 and 522_AT4 and 9551_AT2) or (4905_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 517_AT2 and 9551_AT3 and 522_AT4) or (4905_AT1 and 9551_AT1 and 515_AT2 and 10476_AT2 and 521_AT1 and 518_AT1 and 10632_AT1 and 522_AT5) or (4905_AT1 and 9551_AT1 and 10476_AT2 and 521_AT1 and 518_AT1 and 515_AT1 and 10632_AT1 and 522_AT3) or (4905_AT1 and 9551_AT1 and 522_AT2 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 518_AT2) or (4905_AT1 and 515_AT3 and 522_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 517_AT2 and 9551_AT3) or (518_AT3 and 4905_AT1 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 9551_AT3 and 522_AT3) or (517_AT1 and 4905_AT1 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 522_AT3) or (4905_AT1 and 515_AT3 and 10476_AT2 and 521_AT1 and 518_AT1 and 10632_AT1 and 9551_AT3 and 522_AT4) or (4905_AT1 and 9551_AT1 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 517_AT2 and 522_AT4) or (518_AT3 and 4905_AT1 and 515_AT2 and 522_AT1 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT2) or (518_AT3 and 4905_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 522_AT5 and 9551_AT2) or (4905_AT1 and 515_AT2 and 516_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 522_AT4 and 9551_AT2) or (4905_AT1 and 515_AT3 and 10476_AT2 and 522_AT1 and 516_AT2 and 521_AT1 and 10632_AT1 and 9551_AT2) or (517_AT1 and 4905_AT1 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 9551_AT2 and 522_AT3) or (517_AT1 and 4905_AT1 and 9551_AT1 and 515_AT3 and 10476_AT2 and 521_AT1 and 10632_AT1 and 522_AT4) or (4905_AT1 and 515_AT3 and 516_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 522_AT3) or (4905_AT1 and 516_AT1 and 9551_AT1 and 515_AT3 and 522_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1) or (518_AT3 and 4905_AT1 and 522_AT2 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3) or (4905_AT1 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 517_AT2 and 9551_AT3 and 522_AT4) or (518_AT3 and 4905_AT1 and 515_AT3 and 522_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT2) or (4905_AT1 and 9551_AT1 and 521_AT1 and 518_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 522_AT5) or (4905_AT1 and 515_AT3 and 522_AT2 and 10476_AT2 and 516_AT2 and 521_AT1 and 10632_AT1 and 9551_AT2) or (4905_AT1 and 516_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 522_AT4) or (4905_AT1 and 9551_AT1 and 515_AT3 and 516_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 522_AT5) or (4905_AT1 and 9551_AT1 and 515_AT2 and 10476_AT2 and 516_AT2 and 521_AT1 and 10632_AT1 and 522_AT5) or (517_AT1 and 4905_AT1 and 515_AT3 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 522_AT3))"}, {"subsystem": "Transport, Lysosomal", "name": "ATPasel", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ATPasel"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "h_c": -3.0, "adp_c": 1.0, "h_l": 4.0, "pi_c": 1.0}, "id": "ATPasel", "gene_reaction_rule": "((50617_AT1 and 533_AT1 and 527_AT1 and 8992_AT1 and 245972_AT1) or (50617_AT1 and 533_AT1 and 527_AT1 and 8992_AT1 and 9114_AT1) or (533_AT1 and 527_AT1 and 8992_AT1 and 535_AT1 and 245972_AT1) or (533_AT1 and 527_AT1 and 8992_AT1 and 535_AT1 and 9114_AT1) or (533_AT1 and 527_AT1 and 8992_AT1 and 50617_AT3 and 245972_AT1) or (533_AT1 and 527_AT1 and 8992_AT1 and 10312_AT1 and 9114_AT1) or (533_AT1 and 527_AT1 and 8992_AT1 and 245972_AT1 and 50617_AT2) or (533_AT1 and 527_AT1 and 8992_AT1 and 9114_AT1 and 23545_AT1) or (533_AT1 and 527_AT1 and 8992_AT1 and 10312_AT2 and 245972_AT1) or (533_AT1 and 527_AT1 and 8992_AT1 and 50617_AT3 and 9114_AT1) or (533_AT1 and 527_AT1 and 8992_AT1 and 245972_AT1 and 23545_AT1) or (533_AT1 and 527_AT1 and 8992_AT1 and 9114_AT1 and 50617_AT2) or (533_AT1 and 527_AT1 and 8992_AT1 and 10312_AT1 and 245972_AT1) or (533_AT1 and 527_AT1 and 8992_AT1 and 10312_AT2 and 9114_AT1)) and ((51382_AT1 and 9296_AT1 and 245973_AT1 and 9550_AT1 and 529_AT1 and 523_AT1 and 51606_AT1 and 526_AT1) or (51382_AT1 and 9296_AT1 and 127124_AT1 and 245973_AT1 and 525_AT1 and 90423_AT1 and 51606_AT2 and 523_AT1) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 534_AT2 and 90423_AT1 and 523_AT1 and 526_AT1 and 528_AT2) or (51382_AT1 and 9296_AT1 and 245973_AT1 and 534_AT2 and 90423_AT1 and 523_AT1 and 51606_AT1 and 526_AT1) or (51382_AT1 and 9296_AT1 and 534_AT1 and 51606_AT2 and 529_AT1 and 528_AT1 and 523_AT1 and 526_AT1) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 534_AT1 and 529_AT1 and 523_AT1 and 526_AT1 and 528_AT2) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 127124_AT1 and 525_AT1 and 529_AT1 and 523_AT1 and 528_AT2) or (51382_AT1 and 9296_AT1 and 245973_AT1 and 90423_AT1 and 127124_AT2 and 51606_AT2 and 523_AT1 and 526_AT1) or (51382_AT1 and 9296_AT1 and 127124_AT1 and 525_AT1 and 529_AT1 and 523_AT1 and 51606_AT1 and 528_AT2) or (51382_AT1 and 9296_AT1 and 245973_AT1 and 534_AT2 and 525_AT1 and 51606_AT2 and 529_AT1 and 523_AT1) or (51382_AT1 and 9296_AT1 and 534_AT1 and 90423_AT1 and 528_AT1 and 523_AT1 and 51606_AT1 and 526_AT1) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 90423_AT1 and 9550_AT1 and 523_AT1 and 526_AT1 and 528_AT2) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 534_AT1 and 245973_AT1 and 525_AT1 and 90423_AT1 and 523_AT1) or (51382_AT1 and 9296_AT1 and 534_AT1 and 525_AT1 and 529_AT1 and 528_AT1 and 523_AT1 and 51606_AT1) or (51382_AT1 and 9296_AT1 and 90423_AT1 and 127124_AT2 and 51606_AT2 and 523_AT1 and 526_AT1 and 528_AT2) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 534_AT1 and 90423_AT1 and 528_AT1 and 523_AT1 and 526_AT1) or (51382_AT1 and 9296_AT1 and 525_AT1 and 127124_AT2 and 51606_AT2 and 529_AT1 and 523_AT1 and 528_AT2) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 534_AT1 and 525_AT1 and 529_AT1 and 528_AT1 and 523_AT1) or (51382_AT1 and 9296_AT1 and 127124_AT2 and 529_AT1 and 523_AT1 and 51606_AT1 and 526_AT1 and 528_AT2) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 534_AT2 and 525_AT1 and 90423_AT1 and 528_AT1 and 523_AT1) or (51382_AT1 and 9296_AT1 and 534_AT2 and 90423_AT1 and 51606_AT2 and 523_AT1 and 526_AT1 and 528_AT2) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 525_AT1 and 90423_AT1 and 9550_AT1 and 523_AT1 and 528_AT2) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 534_AT1 and 525_AT1 and 90423_AT1 and 528_AT1 and 523_AT1) or (51382_AT1 and 9296_AT1 and 127124_AT1 and 245973_AT1 and 525_AT1 and 90423_AT1 and 523_AT1 and 51606_AT1) or (51382_AT1 and 9296_AT1 and 245973_AT1 and 525_AT1 and 90423_AT1 and 127124_AT2 and 51606_AT2 and 523_AT1) or (51382_AT1 and 9296_AT1 and 534_AT1 and 525_AT1 and 51606_AT2 and 529_AT1 and 523_AT1 and 528_AT2) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 127124_AT1 and 529_AT1 and 528_AT1 and 523_AT1 and 526_AT1) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 127124_AT1 and 90423_AT1 and 523_AT1 and 526_AT1 and 528_AT2) or (51382_AT1 and 9296_AT1 and 127124_AT1 and 529_AT1 and 523_AT1 and 51606_AT1 and 526_AT1 and 528_AT2) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 525_AT1 and 90423_AT1 and 127124_AT2 and 528_AT1 and 523_AT1) or (51382_AT1 and 9296_AT1 and 90423_AT1 and 127124_AT2 and 51606_AT2 and 528_AT1 and 523_AT1 and 526_AT1) or (51382_AT1 and 9296_AT1 and 245973_AT1 and 534_AT2 and 525_AT1 and 90423_AT1 and 51606_AT2 and 523_AT1) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 127124_AT1 and 245973_AT1 and 529_AT1 and 523_AT1 and 526_AT1) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 245973_AT1 and 90423_AT1 and 9550_AT1 and 523_AT1 and 526_AT1) or (51382_AT1 and 9296_AT1 and 534_AT2 and 90423_AT1 and 528_AT1 and 523_AT1 and 51606_AT1 and 526_AT1) or (51382_AT1 and 9296_AT1 and 127124_AT1 and 525_AT1 and 90423_AT1 and 51606_AT2 and 528_AT1 and 523_AT1) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 534_AT2 and 525_AT1 and 529_AT1 and 523_AT1 and 528_AT2) or (51382_AT1 and 9296_AT1 and 127124_AT1 and 245973_AT1 and 51606_AT2 and 529_AT1 and 523_AT1 and 526_AT1) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 127124_AT2 and 529_AT1 and 528_AT1 and 523_AT1 and 526_AT1) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 534_AT2 and 90423_AT1 and 528_AT1 and 523_AT1 and 526_AT1) or (51382_AT1 and 9296_AT1 and 534_AT1 and 51606_AT2 and 529_AT1 and 523_AT1 and 526_AT1 and 528_AT2) or (51382_AT1 and 9296_AT1 and 534_AT2 and 529_AT1 and 528_AT1 and 523_AT1 and 51606_AT1 and 526_AT1) or (51382_AT1 and 9296_AT1 and 534_AT1 and 90423_AT1 and 51606_AT2 and 523_AT1 and 526_AT1 and 528_AT2) or (51382_AT1 and 9296_AT1 and 127124_AT1 and 529_AT1 and 528_AT1 and 523_AT1 and 51606_AT1 and 526_AT1) or (51382_AT1 and 9296_AT1 and 127124_AT1 and 90423_AT1 and 51606_AT2 and 528_AT1 and 523_AT1 and 526_AT1) or (51382_AT1 and 9296_AT1 and 9550_AT1 and 529_AT1 and 528_AT1 and 523_AT1 and 51606_AT1 and 526_AT1) or (51382_AT1 and 9296_AT1 and 534_AT2 and 525_AT1 and 51606_AT2 and 529_AT1 and 528_AT1 and 523_AT1) or (51382_AT1 and 9296_AT1 and 245973_AT1 and 127124_AT2 and 529_AT1 and 523_AT1 and 51606_AT1 and 526_AT1) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 245973_AT1 and 9550_AT1 and 529_AT1 and 523_AT1 and 526_AT1) or (51382_AT1 and 9296_AT1 and 127124_AT1 and 525_AT1 and 90423_AT1 and 51606_AT2 and 523_AT1 and 528_AT2) or (51382_AT1 and 9296_AT1 and 127124_AT1 and 525_AT1 and 51606_AT2 and 529_AT1 and 523_AT1 and 528_AT2) or (51382_AT1 and 9296_AT1 and 127124_AT2 and 51606_AT2 and 529_AT1 and 523_AT1 and 526_AT1 and 528_AT2) or (51382_AT1 and 9296_AT1 and 90423_AT1 and 9550_AT1 and 523_AT1 and 51606_AT1 and 526_AT1 and 528_AT2) or (51382_AT1 and 9296_AT1 and 534_AT1 and 525_AT1 and 90423_AT1 and 51606_AT2 and 528_AT1 and 523_AT1) or (51382_AT1 and 9296_AT1 and 127124_AT1 and 525_AT1 and 51606_AT2 and 529_AT1 and 528_AT1 and 523_AT1) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 245973_AT1 and 534_AT2 and 529_AT1 and 523_AT1 and 526_AT1) or (51382_AT1 and 9296_AT1 and 534_AT2 and 525_AT1 and 51606_AT2 and 529_AT1 and 523_AT1 and 528_AT2) or (51382_AT1 and 9296_AT1 and 245973_AT1 and 90423_AT1 and 9550_AT1 and 523_AT1 and 51606_AT1 and 526_AT1) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 9550_AT1 and 529_AT1 and 528_AT1 and 523_AT1 and 526_AT1) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 525_AT1 and 127124_AT2 and 529_AT1 and 528_AT1 and 523_AT1) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 525_AT1 and 90423_AT1 and 9550_AT1 and 528_AT1 and 523_AT1) or (51382_AT1 and 9296_AT1 and 245973_AT1 and 525_AT1 and 127124_AT2 and 529_AT1 and 523_AT1 and 51606_AT1) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 534_AT1 and 525_AT1 and 90423_AT1 and 523_AT1 and 528_AT2) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 245973_AT1 and 525_AT1 and 90423_AT1 and 9550_AT1 and 523_AT1) or (51382_AT1 and 9296_AT1 and 245973_AT1 and 127124_AT2 and 51606_AT2 and 529_AT1 and 523_AT1 and 526_AT1) or (51382_AT1 and 9296_AT1 and 245973_AT1 and 90423_AT1 and 127124_AT2 and 523_AT1 and 51606_AT1 and 526_AT1) or (51382_AT1 and 9296_AT1 and 534_AT2 and 51606_AT2 and 529_AT1 and 523_AT1 and 526_AT1 and 528_AT2) or (51382_AT1 and 9296_AT1 and 534_AT1 and 245973_AT1 and 51606_AT2 and 529_AT1 and 523_AT1 and 526_AT1) or (51382_AT1 and 9296_AT1 and 127124_AT1 and 245973_AT1 and 90423_AT1 and 523_AT1 and 51606_AT1 and 526_AT1) or (51382_AT1 and 9296_AT1 and 127124_AT2 and 529_AT1 and 528_AT1 and 523_AT1 and 51606_AT1 and 526_AT1) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 127124_AT1 and 525_AT1 and 90423_AT1 and 528_AT1 and 523_AT1) or (51382_AT1 and 9296_AT1 and 245973_AT1 and 525_AT1 and 90423_AT1 and 9550_AT1 and 51606_AT2 and 523_AT1) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 90423_AT1 and 127124_AT2 and 523_AT1 and 526_AT1 and 528_AT2) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 245973_AT1 and 90423_AT1 and 127124_AT2 and 523_AT1 and 526_AT1) or (51382_AT1 and 9296_AT1 and 525_AT1 and 9550_AT1 and 51606_AT2 and 529_AT1 and 528_AT1 and 523_AT1) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 525_AT1 and 9550_AT1 and 529_AT1 and 528_AT1 and 523_AT1) or (51382_AT1 and 9296_AT1 and 534_AT1 and 525_AT1 and 90423_AT1 and 523_AT1 and 51606_AT1 and 528_AT2) or (51382_AT1 and 9296_AT1 and 127124_AT1 and 245973_AT1 and 525_AT1 and 51606_AT2 and 529_AT1 and 523_AT1) or (51382_AT1 and 9296_AT1 and 525_AT1 and 9550_AT1 and 51606_AT2 and 529_AT1 and 523_AT1 and 528_AT2) or (51382_AT1 and 9296_AT1 and 9550_AT1 and 51606_AT2 and 529_AT1 and 523_AT1 and 526_AT1 and 528_AT2) or (51382_AT1 and 9296_AT1 and 245973_AT1 and 525_AT1 and 9550_AT1 and 529_AT1 and 523_AT1 and 51606_AT1) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 534_AT1 and 245973_AT1 and 90423_AT1 and 523_AT1 and 526_AT1) or (51382_AT1 and 9296_AT1 and 245973_AT1 and 534_AT2 and 525_AT1 and 529_AT1 and 523_AT1 and 51606_AT1) or (51382_AT1 and 9296_AT1 and 525_AT1 and 90423_AT1 and 127124_AT2 and 51606_AT2 and 523_AT1 and 528_AT2) or (51382_AT1 and 9296_AT1 and 525_AT1 and 127124_AT2 and 529_AT1 and 528_AT1 and 523_AT1 and 51606_AT1) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 127124_AT1 and 245973_AT1 and 525_AT1 and 90423_AT1 and 523_AT1) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 525_AT1 and 127124_AT2 and 529_AT1 and 523_AT1 and 528_AT2) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 127124_AT1 and 90423_AT1 and 528_AT1 and 523_AT1 and 526_AT1) or (51382_AT1 and 9296_AT1 and 525_AT1 and 9550_AT1 and 529_AT1 and 523_AT1 and 51606_AT1 and 528_AT2) or (51382_AT1 and 9296_AT1 and 534_AT1 and 245973_AT1 and 525_AT1 and 90423_AT1 and 51606_AT2 and 523_AT1) or (51382_AT1 and 9296_AT1 and 127124_AT2 and 51606_AT2 and 529_AT1 and 528_AT1 and 523_AT1 and 526_AT1) or (51382_AT1 and 9296_AT1 and 245973_AT1 and 534_AT2 and 90423_AT1 and 51606_AT2 and 523_AT1 and 526_AT1) or (51382_AT1 and 9296_AT1 and 534_AT2 and 525_AT1 and 90423_AT1 and 51606_AT2 and 523_AT1 and 528_AT2) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 9550_AT1 and 529_AT1 and 523_AT1 and 526_AT1 and 528_AT2) or (51382_AT1 and 9296_AT1 and 534_AT2 and 525_AT1 and 90423_AT1 and 523_AT1 and 51606_AT1 and 528_AT2) or (51382_AT1 and 9296_AT1 and 534_AT1 and 525_AT1 and 51606_AT2 and 529_AT1 and 528_AT1 and 523_AT1) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 534_AT1 and 529_AT1 and 528_AT1 and 523_AT1 and 526_AT1) or (51382_AT1 and 9296_AT1 and 534_AT2 and 51606_AT2 and 529_AT1 and 528_AT1 and 523_AT1 and 526_AT1) or (51382_AT1 and 9296_AT1 and 127124_AT1 and 90423_AT1 and 528_AT1 and 523_AT1 and 51606_AT1 and 526_AT1) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 127124_AT1 and 529_AT1 and 523_AT1 and 526_AT1 and 528_AT2) or (51382_AT1 and 9296_AT1 and 534_AT1 and 245973_AT1 and 90423_AT1 and 523_AT1 and 51606_AT1 and 526_AT1) or (51382_AT1 and 9296_AT1 and 127124_AT1 and 90423_AT1 and 51606_AT2 and 523_AT1 and 526_AT1 and 528_AT2) or (51382_AT1 and 9296_AT1 and 534_AT2 and 529_AT1 and 523_AT1 and 51606_AT1 and 526_AT1 and 528_AT2) or (51382_AT1 and 9296_AT1 and 534_AT1 and 525_AT1 and 529_AT1 and 523_AT1 and 51606_AT1 and 528_AT2) or (51382_AT1 and 9296_AT1 and 245973_AT1 and 90423_AT1 and 9550_AT1 and 51606_AT2 and 523_AT1 and 526_AT1) or (51382_AT1 and 9296_AT1 and 127124_AT1 and 525_AT1 and 90423_AT1 and 528_AT1 and 523_AT1 and 51606_AT1) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 534_AT2 and 525_AT1 and 90423_AT1 and 523_AT1 and 528_AT2) or (51382_AT1 and 9296_AT1 and 127124_AT1 and 90423_AT1 and 523_AT1 and 51606_AT1 and 526_AT1 and 528_AT2) or (51382_AT1 and 9296_AT1 and 127124_AT1 and 525_AT1 and 529_AT1 and 528_AT1 and 523_AT1 and 51606_AT1) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 127124_AT1 and 245973_AT1 and 525_AT1 and 529_AT1 and 523_AT1) or (51382_AT1 and 9296_AT1 and 127124_AT1 and 51606_AT2 and 529_AT1 and 523_AT1 and 526_AT1 and 528_AT2) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 534_AT1 and 90423_AT1 and 523_AT1 and 526_AT1 and 528_AT2) or (51382_AT1 and 9296_AT1 and 525_AT1 and 90423_AT1 and 9550_AT1 and 51606_AT2 and 523_AT1 and 528_AT2) or (51382_AT1 and 9296_AT1 and 127124_AT1 and 51606_AT2 and 529_AT1 and 528_AT1 and 523_AT1 and 526_AT1) or (51382_AT1 and 9296_AT1 and 245973_AT1 and 534_AT2 and 529_AT1 and 523_AT1 and 51606_AT1 and 526_AT1) or (51382_AT1 and 9296_AT1 and 534_AT2 and 525_AT1 and 90423_AT1 and 528_AT1 and 523_AT1 and 51606_AT1) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 127124_AT1 and 245973_AT1 and 90423_AT1 and 523_AT1 and 526_AT1) or (51382_AT1 and 9296_AT1 and 245973_AT1 and 525_AT1 and 127124_AT2 and 51606_AT2 and 529_AT1 and 523_AT1) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 245973_AT1 and 525_AT1 and 9550_AT1 and 529_AT1 and 523_AT1) or (51382_AT1 and 9296_AT1 and 90423_AT1 and 127124_AT2 and 528_AT1 and 523_AT1 and 51606_AT1 and 526_AT1) or (51382_AT1 and 9296_AT1 and 9550_AT1 and 529_AT1 and 523_AT1 and 51606_AT1 and 526_AT1 and 528_AT2) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 534_AT1 and 525_AT1 and 529_AT1 and 523_AT1 and 528_AT2) or (51382_AT1 and 9296_AT1 and 534_AT1 and 245973_AT1 and 525_AT1 and 51606_AT2 and 529_AT1 and 523_AT1) or (51382_AT1 and 9296_AT1 and 90423_AT1 and 9550_AT1 and 528_AT1 and 523_AT1 and 51606_AT1 and 526_AT1) or (51382_AT1 and 9296_AT1 and 525_AT1 and 90423_AT1 and 9550_AT1 and 523_AT1 and 51606_AT1 and 528_AT2) or (51382_AT1 and 9296_AT1 and 534_AT1 and 90423_AT1 and 51606_AT2 and 528_AT1 and 523_AT1 and 526_AT1) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 245973_AT1 and 534_AT2 and 525_AT1 and 529_AT1 and 523_AT1) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 90423_AT1 and 127124_AT2 and 528_AT1 and 523_AT1 and 526_AT1) or (51382_AT1 and 9296_AT1 and 525_AT1 and 127124_AT2 and 529_AT1 and 523_AT1 and 51606_AT1 and 528_AT2) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 90423_AT1 and 9550_AT1 and 528_AT1 and 523_AT1 and 526_AT1) or (51382_AT1 and 9296_AT1 and 534_AT1 and 529_AT1 and 528_AT1 and 523_AT1 and 51606_AT1 and 526_AT1) or (51382_AT1 and 9296_AT1 and 9550_AT1 and 51606_AT2 and 529_AT1 and 528_AT1 and 523_AT1 and 526_AT1) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 534_AT2 and 525_AT1 and 529_AT1 and 528_AT1 and 523_AT1) or (51382_AT1 and 9296_AT1 and 127124_AT1 and 525_AT1 and 90423_AT1 and 523_AT1 and 51606_AT1 and 528_AT2) or (51382_AT1 and 9296_AT1 and 127124_AT1 and 245973_AT1 and 529_AT1 and 523_AT1 and 51606_AT1 and 526_AT1) or (51382_AT1 and 9296_AT1 and 534_AT2 and 90423_AT1 and 523_AT1 and 51606_AT1 and 526_AT1 and 528_AT2) or (51382_AT1 and 9296_AT1 and 534_AT1 and 245973_AT1 and 90423_AT1 and 51606_AT2 and 523_AT1 and 526_AT1) or (51382_AT1 and 9296_AT1 and 525_AT1 and 90423_AT1 and 9550_AT1 and 51606_AT2 and 528_AT1 and 523_AT1) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 245973_AT1 and 127124_AT2 and 529_AT1 and 523_AT1 and 526_AT1) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 245973_AT1 and 534_AT2 and 525_AT1 and 90423_AT1 and 523_AT1) or (51382_AT1 and 9296_AT1 and 534_AT1 and 529_AT1 and 523_AT1 and 51606_AT1 and 526_AT1 and 528_AT2) or (51382_AT1 and 9296_AT1 and 534_AT1 and 245973_AT1 and 525_AT1 and 90423_AT1 and 523_AT1 and 51606_AT1) or (51382_AT1 and 9296_AT1 and 245973_AT1 and 9550_AT1 and 51606_AT2 and 529_AT1 and 523_AT1 and 526_AT1) or (51382_AT1 and 9296_AT1 and 245973_AT1 and 534_AT2 and 525_AT1 and 90423_AT1 and 523_AT1 and 51606_AT1) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 245973_AT1 and 534_AT2 and 90423_AT1 and 523_AT1 and 526_AT1) or (51382_AT1 and 9296_AT1 and 525_AT1 and 90423_AT1 and 127124_AT2 and 51606_AT2 and 528_AT1 and 523_AT1) or (51382_AT1 and 9296_AT1 and 245973_AT1 and 534_AT2 and 51606_AT2 and 529_AT1 and 523_AT1 and 526_AT1) or (51382_AT1 and 9296_AT1 and 534_AT1 and 245973_AT1 and 525_AT1 and 529_AT1 and 523_AT1 and 51606_AT1) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 534_AT2 and 529_AT1 and 528_AT1 and 523_AT1 and 526_AT1) or (51382_AT1 and 9296_AT1 and 90423_AT1 and 9550_AT1 and 51606_AT2 and 523_AT1 and 526_AT1 and 528_AT2) or (51382_AT1 and 9296_AT1 and 534_AT2 and 90423_AT1 and 51606_AT2 and 528_AT1 and 523_AT1 and 526_AT1) or (51382_AT1 and 9296_AT1 and 534_AT1 and 525_AT1 and 90423_AT1 and 51606_AT2 and 523_AT1 and 528_AT2) or (51382_AT1 and 9296_AT1 and 534_AT2 and 525_AT1 and 90423_AT1 and 51606_AT2 and 528_AT1 and 523_AT1) or (51382_AT1 and 9296_AT1 and 525_AT1 and 90423_AT1 and 127124_AT2 and 528_AT1 and 523_AT1 and 51606_AT1) or (51382_AT1 and 9296_AT1 and 534_AT1 and 245973_AT1 and 529_AT1 and 523_AT1 and 51606_AT1 and 526_AT1) or (51382_AT1 and 9296_AT1 and 90423_AT1 and 9550_AT1 and 51606_AT2 and 528_AT1 and 523_AT1 and 526_AT1) or (51382_AT1 and 9296_AT1 and 127124_AT1 and 245973_AT1 and 90423_AT1 and 51606_AT2 and 523_AT1 and 526_AT1) or (51382_AT1 and 9296_AT1 and 525_AT1 and 90423_AT1 and 9550_AT1 and 528_AT1 and 523_AT1 and 51606_AT1) or (51382_AT1 and 9296_AT1 and 525_AT1 and 9550_AT1 and 529_AT1 and 528_AT1 and 523_AT1 and 51606_AT1) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 534_AT1 and 245973_AT1 and 525_AT1 and 529_AT1 and 523_AT1) or (51382_AT1 and 9296_AT1 and 245973_AT1 and 525_AT1 and 90423_AT1 and 9550_AT1 and 523_AT1 and 51606_AT1) or (51382_AT1 and 9296_AT1 and 127124_AT1 and 245973_AT1 and 525_AT1 and 529_AT1 and 523_AT1 and 51606_AT1) or (51382_AT1 and 9296_AT1 and 534_AT2 and 525_AT1 and 529_AT1 and 523_AT1 and 51606_AT1 and 528_AT2) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 534_AT2 and 529_AT1 and 523_AT1 and 526_AT1 and 528_AT2) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 525_AT1 and 90423_AT1 and 127124_AT2 and 523_AT1 and 528_AT2) or (51382_AT1 and 9296_AT1 and 534_AT1 and 90423_AT1 and 523_AT1 and 51606_AT1 and 526_AT1 and 528_AT2) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 245973_AT1 and 525_AT1 and 90423_AT1 and 127124_AT2 and 523_AT1) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 127124_AT1 and 525_AT1 and 90423_AT1 and 523_AT1 and 528_AT2) or (51382_AT1 and 9296_AT1 and 90423_AT1 and 127124_AT2 and 523_AT1 and 51606_AT1 and 526_AT1 and 528_AT2) or (51382_AT1 and 9296_AT1 and 534_AT1 and 525_AT1 and 90423_AT1 and 528_AT1 and 523_AT1 and 51606_AT1) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 245973_AT1 and 525_AT1 and 127124_AT2 and 529_AT1 and 523_AT1) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 525_AT1 and 9550_AT1 and 529_AT1 and 523_AT1 and 528_AT2) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 127124_AT2 and 529_AT1 and 523_AT1 and 526_AT1 and 528_AT2) or (51382_AT1 and 9296_AT1 and 245973_AT1 and 525_AT1 and 9550_AT1 and 51606_AT2 and 529_AT1 and 523_AT1) or (51382_AT1 and 9296_AT1 and 525_AT1 and 90423_AT1 and 127124_AT2 and 523_AT1 and 51606_AT1 and 528_AT2) or (51382_AT1 and 9296_AT1 and 245973_AT1 and 525_AT1 and 90423_AT1 and 127124_AT2 and 523_AT1 and 51606_AT1) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 127124_AT1 and 525_AT1 and 529_AT1 and 528_AT1 and 523_AT1) or (51382_AT1 and 9296_AT1 and 534_AT2 and 525_AT1 and 529_AT1 and 528_AT1 and 523_AT1 and 51606_AT1) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 534_AT1 and 245973_AT1 and 529_AT1 and 523_AT1 and 526_AT1) or (51382_AT1 and 9296_AT1 and 525_AT1 and 127124_AT2 and 51606_AT2 and 529_AT1 and 528_AT1 and 523_AT1))"}, {"subsystem": "Transport, Mitochondrial", "name": "ATPtm", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ATPtm"]}, "metabolites": {"adp_m": 1.0, "atp_m": -1.0, "atp_c": 1.0, "adp_c": -1.0}, "id": "ATPtm", "gene_reaction_rule": "291_AT1 or 293_AT1 or 292_AT1"}, {"subsystem": "Transport, Nuclear", "name": "ATPtn", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["ATPtn"]}, "metabolites": {"atp_n": 1.0, "atp_c": -1.0}, "id": "ATPtn", "gene_reaction_rule": ""}, {"subsystem": "Transport, Peroxisomal", "name": "ATPtx", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["ATPtx"]}, "metabolites": {"atp_x": 1.0, "atp_c": -1.0}, "id": "ATPtx", "gene_reaction_rule": ""}, {"subsystem": "Transport, Extracellular", "name": "AVITE1t", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AVITE1t"]}, "metabolites": {"avite1_c": 1.0, "avite1_e": -1.0}, "id": "AVITE1t", "gene_reaction_rule": ""}, {"subsystem": "Transport, Extracellular", "name": "AVITE2t", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AVITE2t"]}, "metabolites": {"avite2_e": -1.0, "avite2_c": 1.0}, "id": "AVITE2t", "gene_reaction_rule": ""}, {"subsystem": "N-Glycan Degradation", "name": "A MANASE", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["A_MANASE"]}, "metabolites": {"m2mn_c": -1.0, "h2o_c": -2.0, "mn_c": 1.0, "man_c": 2.0}, "id": "A_MANASE", "gene_reaction_rule": "4123_AT1"}, {"subsystem": "N-Glycan Degradation", "name": "A MANASEly", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["A_MANASEly"]}, "metabolites": {"man_l": 2.0, "mn_l": 1.0, "h2o_l": -2.0, "m2mn_l": -1.0}, "id": "A_MANASEly", "gene_reaction_rule": "4125_AT1"}, {"subsystem": "Sphingolipid Metabolism", "name": "B3GALT3g", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["B3GALT3g"]}, "metabolites": {"h_g": 1.0, "udpacgal_g": -1.0, "thcrm_hs_g": -1.0, "udp_g": 1.0, "gbside_hs_g": 1.0}, "id": "B3GALT3g", "gene_reaction_rule": "8706_AT4 or 8706_AT1 or 8706_AT3 or 8706_AT2"}, {"subsystem": "Sphingolipid Metabolism", "name": "B3GALT41g", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["B3GALT41g"]}, "metabolites": {"ga2_hs_g": -1.0, "h_g": 1.0, "ga1_hs_g": 1.0, "udp_g": 1.0, "udpgal_g": -1.0}, "id": "B3GALT41g", "gene_reaction_rule": "8705_AT1"}, {"subsystem": "Sphingolipid Metabolism", "name": "B3GALT42g", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["B3GALT42g"]}, "metabolites": {"gm1_hs_g": 1.0, "gm2_hs_g": -1.0, "udpgal_g": -1.0, "udp_g": 1.0, "h_g": 1.0}, "id": "B3GALT42g", "gene_reaction_rule": "8705_AT1"}, {"subsystem": "Sphingolipid Metabolism", "name": "B3GALT43g", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["B3GALT43g"]}, "metabolites": {"h_g": 1.0, "gd1b_hs_g": 1.0, "udpgal_g": -1.0, "udp_g": 1.0, "gd2_hs_g": -1.0}, "id": "B3GALT43g", "gene_reaction_rule": "8705_AT1"}, {"subsystem": "Sphingolipid Metabolism", "name": "B3GALT44g", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["B3GALT44g"]}, "metabolites": {"h_g": 1.0, "gt1c_hs_g": 1.0, "udpgal_g": -1.0, "udp_g": 1.0, "gt2_hs_g": -1.0}, "id": "B3GALT44g", "gene_reaction_rule": "8705_AT1"}, {"subsystem": "Sphingolipid Metabolism", "name": "B3GALT5g", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["B3GALT5g"]}, "metabolites": {"h_g": 1.0, "galgbside_hs_g": 1.0, "udpgal_g": -1.0, "udp_g": 1.0, "gbside_hs_g": -1.0}, "id": "B3GALT5g", "gene_reaction_rule": "10317_AT4 or 10317_AT1 or 10317_AT3 or 10317_AT2 or 10317_AT5"}, {"subsystem": "Blood Group Biosynthesis", "name": "B3GALTg", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["B3GALTg"]}, "metabolites": {"galacglcgalgluside_hs_g": 1.0, "h_g": 1.0, "acglcgalgluside_hs_g": -1.0, "udpgal_g": -1.0, "udp_g": 1.0}, "id": "B3GALTg", "gene_reaction_rule": ""}, {"subsystem": "Blood Group Biosynthesis", "name": "B3GNT11g", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["B3GNT11g"]}, "metabolites": {"h_g": 1.0, "uacgam_g": -1.0, "udp_g": 1.0, "acglcgal14acglcgalgluside_hs_g": 1.0, "gal14acglcgalgluside_hs_g": -1.0}, "id": "B3GNT11g", "gene_reaction_rule": "10678_AT1"}, {"subsystem": "Blood Group Biosynthesis", "name": "B3GNT12g", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["B3GNT12g"]}, "metabolites": {"acglc13galacglcgal14acglcgalgluside_hs_g": 1.0, "galacglcgal14acglcgalgluside_hs_g": -1.0, "uacgam_g": -1.0, "udp_g": 1.0, "h_g": 1.0}, "id": "B3GNT12g", "gene_reaction_rule": "10678_AT1 or 10678_AT2"}, {"subsystem": "Blood Group Biosynthesis", "name": "B3GNT310g", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["B3GNT310g"]}, "metabolites": {"h_g": 1.0, "acglcgalgluside_hs_g": -1.0, "udpgal_g": -1.0, "udp_g": 1.0, "gal14acglcgalgluside_hs_g": 1.0}, "id": "B3GNT310g", "gene_reaction_rule": "10331_AT1"}, {"subsystem": "Blood Group Biosynthesis", "name": "B3GNT311g", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["B3GNT311g"]}, 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"id": "G16MT_L", "gene_reaction_rule": ""}, {"subsystem": "N-Glycan Biosynthesis", "name": "G16MT U", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["G16MT_U"]}, "metabolites": {"gdpmann_c": -1.0, "m1mpdol_U_c": -0.1, "gdp_c": 1.0, "h_c": 1.0, "m2mpdol_U_c": 0.1}, "id": "G16MT_U", "gene_reaction_rule": ""}, {"subsystem": "N-Glycan Biosynthesis", "name": "G1M6MASNB1terg", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["G1M6MASNB1terg"]}, "metabolites": {"g1m6masnB1_g": 1.0, "g1m6masnB1_r": -1.0}, "id": "G1M6MASNB1terg", "gene_reaction_rule": ""}, {"subsystem": "N-Glycan Biosynthesis", "name": "G1M7MASNBterg", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["G1M7MASNBterg"]}, "metabolites": {"g1m7masnB_g": 1.0, "g1m7masnB_r": -1.0}, "id": "G1M7MASNBterg", "gene_reaction_rule": ""}, {"subsystem": "N-Glycan Biosynthesis", "name": "G1M7MASNCterg", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": 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{"subsystem": "N-Glycan Biosynthesis", "name": "G3M8MASNterg", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["G3M8MASNterg"]}, "metabolites": {"g3m8masn_r": -1.0, "g3m8masn_g": 1.0}, "id": "G3M8MASNterg", "gene_reaction_rule": ""}, {"subsystem": "Glycerophospholipid Metabolism", "name": "G3PD1", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["G3PD1"]}, "metabolites": {"glyc3p_c": -1.0, "nadh_c": 1.0, "nad_c": -1.0, "dhap_c": 1.0, "h_c": 1.0}, "id": "G3PD1", "gene_reaction_rule": "2819_AT1"}, {"subsystem": "Glycolysis/Gluconeogenesis", "name": "G3PD2m", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["G3PD2m"]}, "metabolites": {"fad_m": -1.0, "glyc3p_c": -1.0, "dhap_c": 1.0, "fadh2_m": 1.0}, "id": "G3PD2m", "gene_reaction_rule": "2820_AT1"}, {"subsystem": "Arginine and Proline Metabolism", "name": "L glutamate 5 semialdehyde dehydratase reversible mitochondrial", "upper_bound": 999999.0, 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{"original_bigg_ids": ["GALASE6ly"]}, "metabolites": {"gal_l": 1.0, "h2o_l": -1.0, "ksi_deg15_l": 1.0, "ksi_deg14_l": -1.0}, "id": "GALASE6ly", "gene_reaction_rule": "(5476_AT1 and 2720_AT1 and 2588_AT1 and 4758_AT1) or (5476_AT1 and 2720_AT1)"}, {"subsystem": "Keratan sulfate degradation", "name": "GALASE7ly", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GALASE7ly"]}, "metabolites": {"ksi_deg17_l": -1.0, "ksi_deg18_l": 1.0, "gal_l": 1.0, "h2o_l": -1.0}, "id": "GALASE7ly", "gene_reaction_rule": "(5476_AT1 and 2720_AT1 and 2588_AT1 and 4758_AT1) or (5476_AT1 and 2720_AT1)"}, {"subsystem": "Keratan sulfate degradation", "name": "GALASE8ly", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GALASE8ly"]}, "metabolites": {"ksi_deg20_l": -1.0, "ksi_deg21_l": 1.0, "gal_l": 1.0, "h2o_l": -1.0}, "id": "GALASE8ly", "gene_reaction_rule": "(5476_AT1 and 2720_AT1 and 2588_AT1 and 4758_AT1) or (5476_AT1 and 2720_AT1)"}, {"subsystem": "Keratan sulfate degradation", "name": "GALASE9ly", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GALASE9ly"]}, "metabolites": {"gal_l": 1.0, "h2o_l": -1.0, "ksi_deg24_l": 1.0, "ksi_deg23_l": -1.0}, "id": "GALASE9ly", "gene_reaction_rule": "(5476_AT1 and 2720_AT1 and 2588_AT1 and 4758_AT1) or (5476_AT1 and 2720_AT1)"}, {"subsystem": "Sphingolipid Metabolism", "name": "GALC", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GALC"]}, "metabolites": {"crm_hs_l": 1.0, "gal_l": 1.0, "h2o_l": -1.0, "galside_hs_l": -1.0}, "id": "GALC", "gene_reaction_rule": "2581_AT1"}, {"subsystem": "Transport, Extracellular", "name": "GALFUC12GAL14ACGLCGALGLUSIDEte", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["GALFUC12GAL14ACGLCGALGLUSIDEte"]}, "metabolites": {"galfuc12gal14acglcgalgluside_hs_c": 1.0, "galfuc12gal14acglcgalgluside_hs_e": -1.0}, "id": "GALFUC12GAL14ACGLCGALGLUSIDEte", "gene_reaction_rule": ""}, {"subsystem": "Transport, Golgi Apparatus", "name": "GALFUC12GAL14ACGLCGALGLUSIDEtg", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["GALFUC12GAL14ACGLCGALGLUSIDEtg"]}, "metabolites": {"galfuc12gal14acglcgalgluside_hs_c": 1.0, "galfuc12gal14acglcgalgluside_hs_g": -1.0}, "id": "GALFUC12GAL14ACGLCGALGLUSIDEtg", "gene_reaction_rule": ""}, {"subsystem": "Transport, Extracellular", "name": "GALFUCGALACGLCGAL14ACGLCGALGLUSIDEte", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["GALFUCGALACGLCGAL14ACGLCGALGLUSIDEte"]}, "metabolites": {"galfucgalacglcgal14acglcgalgluside_hs_e": -1.0, "galfucgalacglcgal14acglcgalgluside_hs_c": 1.0}, "id": "GALFUCGALACGLCGAL14ACGLCGALGLUSIDEte", "gene_reaction_rule": ""}, {"subsystem": "Transport, Golgi Apparatus", "name": "GALFUCGALACGLCGAL14ACGLCGALGLUSIDEtg", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["GALFUCGALACGLCGAL14ACGLCGALGLUSIDEtg"]}, "metabolites": {"galfucgalacglcgal14acglcgalgluside_hs_g": -1.0, "galfucgalacglcgal14acglcgalgluside_hs_c": 1.0}, "id": "GALFUCGALACGLCGAL14ACGLCGALGLUSIDEtg", "gene_reaction_rule": ""}, {"subsystem": "Transport, Extracellular", "name": "GALGALFUCFUCGALACGLCGALACGLCGAL14ACGLCGALGLUSIDEte", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["GALGALFUCFUCGALACGLCGALACGLCGAL14ACGLCGALGLUSIDEte"]}, "metabolites": {"galgalfucfucgalacglcgalacglcgal14acglcgalgluside_hs_c": 1.0, "galgalfucfucgalacglcgalacglcgal14acglcgalgluside_hs_e": -1.0}, "id": "GALGALFUCFUCGALACGLCGALACGLCGAL14ACGLCGALGLUSIDEte", "gene_reaction_rule": ""}, {"subsystem": "Transport, Golgi Apparatus", "name": "GALGALFUCFUCGALACGLCGALACGLCGAL14ACGLCGALGLUSIDEtg", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["GALGALFUCFUCGALACGLCGALACGLCGAL14ACGLCGALGLUSIDEtg"]}, "metabolites": {"galgalfucfucgalacglcgalacglcgal14acglcgalgluside_hs_c": 1.0, "galgalfucfucgalacglcgalacglcgal14acglcgalgluside_hs_g": -1.0}, "id": "GALGALFUCFUCGALACGLCGALACGLCGAL14ACGLCGALGLUSIDEtg", "gene_reaction_rule": ""}, {"subsystem": "Transport, Extracellular", "name": "GALGALGALTHCRMte", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["GALGALGALTHCRMte"]}, "metabolites": {"galgalgalthcrm_hs_c": -1.0, "galgalgalthcrm_hs_e": 1.0}, "id": "GALGALGALTHCRMte", "gene_reaction_rule": ""}, {"subsystem": "Transport, Golgi Apparatus", "name": "GALGALGALTHCRMtg", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["GALGALGALTHCRMtg"]}, "metabolites": {"galgalgalthcrm_hs_c": -1.0, "galgalgalthcrm_hs_g": 1.0}, "id": "GALGALGALTHCRMtg", "gene_reaction_rule": ""}, {"subsystem": "Transport, Golgi Apparatus", "name": "GALGLUSIDEtg", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["GALGLUSIDEtg"]}, "metabolites": {"galgluside_hs_g": 1.0, "galgluside_hs_c": -1.0}, "id": "GALGLUSIDEtg", "gene_reaction_rule": ""}, {"subsystem": "Transport, Lysosomal", "name": "GALGLUSIDEtl", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["GALGLUSIDEtl"]}, "metabolites": {"galgluside_hs_l": 1.0, "galgluside_hs_c": -1.0}, "id": "GALGLUSIDEtl", "gene_reaction_rule": ""}, {"subsystem": "Sphingolipid Metabolism", "name": "GALGT1", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GALGT1"]}, "metabolites": {"ga2_hs_g": 1.0, "galgluside_hs_g": -1.0, "udpacgal_g": -1.0, "udp_g": 1.0, "h_g": 1.0}, "id": "GALGT1", "gene_reaction_rule": "2583_AT1"}, {"subsystem": "Sphingolipid Metabolism", "name": "GALGT2", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GALGT2"]}, "metabolites": {"h_g": 1.0, "udpacgal_g": -1.0, "gm2_hs_g": 1.0, "udp_g": 1.0, "gm3_hs_g": -1.0}, "id": "GALGT2", "gene_reaction_rule": "2583_AT1"}, {"subsystem": "Sphingolipid Metabolism", "name": "GALGT3", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GALGT3"]}, "metabolites": {"h_g": 1.0, "udpacgal_g": -1.0, "gd3_hs_g": -1.0, "udp_g": 1.0, "gd2_hs_g": 1.0}, "id": "GALGT3", "gene_reaction_rule": "2583_AT1"}, {"subsystem": "Sphingolipid Metabolism", "name": "GALGT4", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GALGT4"]}, "metabolites": {"gt2_hs_g": 1.0, "udpacgal_g": -1.0, "gt3_hs_g": -1.0, "udp_g": 1.0, "h_g": 1.0}, "id": "GALGT4", "gene_reaction_rule": "2583_AT1"}, {"subsystem": "Galactose metabolism", "name": "Galactokinase", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GALK"]}, "metabolites": {"adp_c": 1.0, "gal_c": -1.0, "h_c": 1.0, "atp_c": -1.0, "gal1p_c": 1.0}, "id": "GALKr", "gene_reaction_rule": "2584_AT1 or 2585_AT2 or 2585_AT1"}, {"subsystem": "Chondroitin / heparan sulfate biosynthesis", "name": "GALNACT1g", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GALNACT1g"]}, "metabolites": {"h_g": 1.0, "udpacgal_g": -1.0, "cs_hs_linkage_g": -1.0, "udp_g": 1.0, "cs_pre_g": 1.0}, "id": "GALNACT1g", "gene_reaction_rule": "55790_AT1 or 55454_AT1"}, {"subsystem": "Chondroitin / heparan sulfate biosynthesis", "name": "GALNACT2g", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GALNACT2g"]}, "metabolites": {"cs_a_b_pre2_g": -1.0, "uacgam_g": -1.0, "cs_a_b_pre3_g": 1.0, "udp_g": 1.0, "h_g": 1.0}, "id": "GALNACT2g", "gene_reaction_rule": "55790_AT1 or (79586_AT1 and 22856_AT1) or 55454_AT1 or 337876_AT1"}, {"subsystem": "Chondroitin / heparan sulfate biosynthesis", "name": "GALNACT3g", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GALNACT3g"]}, "metabolites": {"h_g": 1.0, "uacgam_g": -1.0, "cs_c_pre3_g": 1.0, "cs_c_pre2_g": -1.0, "udp_g": 1.0}, "id": "GALNACT3g", "gene_reaction_rule": "55790_AT1 or (79586_AT1 and 22856_AT1) or 55454_AT1 or 337876_AT1"}, {"subsystem": "Chondroitin / 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"2655_AT1"}, {"subsystem": "Starch and Sucrose Metabolism", "name": "GGNG", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GGNG"]}, "metabolites": {"udp_c": 8.0, "ggn_c": 1.0, "udpg_c": -8.0, "h_c": 8.0, "Tyr_ggn_c": -1.0}, "id": "GGNG", "gene_reaction_rule": "(8908_AT1 and 2998_AT1) or (2998_AT1 and 2992_AT1) or (2997_AT1 and 2992_AT1) or (8908_AT1 and 2997_AT1)"}, {"subsystem": "Eicosanoid Metabolism", "name": "GGT5r", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["GGT5r"]}, "metabolites": {"glu__L_r": 1.0, "h2o_r": -1.0, "leuktrD4_r": 1.0, "leuktrC4_r": -1.0}, "id": "GGT5r", "gene_reaction_rule": "2687_AT1"}, {"subsystem": "Eicosanoid Metabolism", "name": "GGT6", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["GGT6"]}, "metabolites": {"leuktrE4_c": -1.0, "leuktrF4_c": 1.0, "glu__L_c": -1.0, "h2o_c": 1.0}, "id": "GGT6", "gene_reaction_rule": ""}, {"subsystem": "N-Glycan 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4758_AT1) or (5476_AT1 and 2720_AT1)"}, {"subsystem": "Starch and Sucrose Metabolism", "name": "GLBRAN", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLBRAN"]}, "metabolites": {"glygn2_c": 1.0, "glygn1_c": -1.0}, "id": "GLBRAN", "gene_reaction_rule": "2632_AT1"}, {"subsystem": "Heparan sulfate degradation", "name": "GLCAASE1ly", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLCAASE1ly"]}, "metabolites": {"glcur_l": 1.0, "hs_deg9_l": -1.0, "h2o_l": -1.0, "hs_deg10_l": 1.0}, "id": "GLCAASE1ly", "gene_reaction_rule": "2990_AT1"}, {"subsystem": "Chondroitin sulfate degradation", "name": "GLCAASE4ly", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLCAASE4ly"]}, "metabolites": {"cs_a_deg3_l": 1.0, "cs_a_deg2_l": -1.0, "glcur_l": 1.0, "h2o_l": -1.0}, "id": "GLCAASE4ly", "gene_reaction_rule": "2990_AT1"}, {"subsystem": "Chondroitin sulfate degradation", "name": "GLCAASE5ly", "upper_bound": 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"Keratan sulfate degradation", "name": "NACHEXA10ly", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NACHEXA10ly"]}, "metabolites": {"h2o_l": -2.0, "acgam_l": 1.0, "ksi_deg9_l": -1.0, "ksi_deg11_l": 1.0, "h_l": 1.0, "so4_l": 1.0}, "id": "NACHEXA10ly", "gene_reaction_rule": "3073_AT1 or (3073_AT1 and 3074_AT1)"}, {"subsystem": "Keratan sulfate degradation", "name": "NACHEXA11ly", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NACHEXA11ly"]}, "metabolites": {"ksi_deg12_l": -1.0, "h2o_l": -2.0, "acgam_l": 1.0, "ksi_deg14_l": 1.0, "h_l": 1.0, "so4_l": 1.0}, "id": "NACHEXA11ly", "gene_reaction_rule": "(3073_AT1 and 3074_AT1) or 3073_AT1"}, {"subsystem": "Keratan sulfate degradation", "name": "NACHEXA12ly", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NACHEXA12ly"]}, "metabolites": {"ksi_deg17_l": 1.0, "h2o_l": -2.0, "acgam_l": 1.0, "so4_l": 1.0, "h_l": 1.0, "ksi_deg15_l": -1.0}, "id": "NACHEXA12ly", "gene_reaction_rule": "(3073_AT1 and 3074_AT1) or 3073_AT1"}, {"subsystem": "Keratan sulfate degradation", "name": "NACHEXA13ly", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NACHEXA13ly"]}, "metabolites": {"ksi_deg20_l": 1.0, "ksi_deg18_l": -1.0, "h2o_l": -2.0, "acgam_l": 1.0, "h_l": 1.0, "so4_l": 1.0}, "id": "NACHEXA13ly", "gene_reaction_rule": "(3073_AT1 and 3074_AT1) or 3073_AT1"}, {"subsystem": "Keratan sulfate degradation", "name": "NACHEXA14ly", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NACHEXA14ly"]}, "metabolites": {"ksi_deg23_l": 1.0, "h2o_l": -2.0, "acgam_l": 1.0, "h_l": 1.0, "ksi_deg21_l": -1.0, "so4_l": 1.0}, "id": "NACHEXA14ly", "gene_reaction_rule": "(3073_AT1 and 3074_AT1) or 3073_AT1"}, {"subsystem": "Keratan sulfate degradation", "name": "NACHEXA15ly", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NACHEXA15ly"]}, "metabolites": {"ksi_deg24_l": -1.0, "ksi_deg26_l": 1.0, "h2o_l": -2.0, "acgam_l": 1.0, "h_l": 1.0, "so4_l": 1.0}, "id": "NACHEXA15ly", "gene_reaction_rule": "(3073_AT1 and 3074_AT1) or 3073_AT1"}, {"subsystem": "Keratan sulfate degradation", "name": "NACHEXA16ly", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NACHEXA16ly"]}, "metabolites": {"ksi_deg27_l": -1.0, "ksi_deg29_l": 1.0, "h2o_l": -2.0, "acgam_l": 1.0, "h_l": 1.0, "so4_l": 1.0}, "id": "NACHEXA16ly", "gene_reaction_rule": "(3073_AT1 and 3074_AT1) or 3073_AT1"}, {"subsystem": "Keratan sulfate degradation", "name": "NACHEXA17ly", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NACHEXA17ly"]}, "metabolites": {"h2o_l": -2.0, "ksi_deg30_l": -1.0, "acgam_l": 1.0, "h_l": 1.0, "ksi_deg32_l": 1.0, "so4_l": 1.0}, "id": "NACHEXA17ly", "gene_reaction_rule": "(3073_AT1 and 3074_AT1) or 3073_AT1"}, {"subsystem": "Keratan sulfate degradation", "name": "NACHEXA18ly", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NACHEXA18ly"]}, "metabolites": {"ksi_deg33_l": -1.0, "ksi_deg35_l": 1.0, "h2o_l": -2.0, "acgam_l": 1.0, "h_l": 1.0, "so4_l": 1.0}, "id": "NACHEXA18ly", "gene_reaction_rule": "(3073_AT1 and 3074_AT1) or 3073_AT1"}, {"subsystem": "Keratan sulfate degradation", "name": "NACHEXA19ly", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NACHEXA19ly"]}, "metabolites": {"h2o_l": -2.0, "acgam_l": 1.0, "ksi_deg38_l": 1.0, "h_l": 1.0, "so4_l": 1.0, "ksi_deg36_l": -1.0}, "id": "NACHEXA19ly", "gene_reaction_rule": "(3073_AT1 and 3074_AT1) or 3073_AT1"}, {"subsystem": "Chondroitin sulfate degradation", "name": "NACHEXA1ly", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NACHEXA1ly"]}, "metabolites": {"cs_a_deg2_l": 1.0, "acgal_l": 1.0, "h2o_l": -2.0, "cs_a_l": -1.0, "h_l": 1.0, "so4_l": 1.0}, "id": "NACHEXA1ly", "gene_reaction_rule": "(3073_AT1 and 3074_AT1) or 3073_AT1"}, {"subsystem": "Keratan sulfate degradation", "name": "NACHEXA20ly", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NACHEXA20ly"]}, "metabolites": {"ksii_core2_deg5_l": 1.0, "h2o_l": -2.0, "acgam_l": 1.0, "ksii_core2_deg3_l": -1.0, "h_l": 1.0, "so4_l": 1.0}, "id": "NACHEXA20ly", "gene_reaction_rule": "(3073_AT1 and 3074_AT1) or 3073_AT1"}, {"subsystem": "Keratan sulfate degradation", "name": "NACHEXA21ly", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NACHEXA21ly"]}, "metabolites": {"h2o_l": -2.0, "acgam_l": 1.0, "ksii_core2_deg6_l": -1.0, "h_l": 1.0, "ksii_core2_deg8_l": 1.0, "so4_l": 1.0}, "id": "NACHEXA21ly", "gene_reaction_rule": "(3073_AT1 and 3074_AT1) or 3073_AT1"}, {"subsystem": "Keratan sulfate degradation", "name": "NACHEXA22ly", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NACHEXA22ly"]}, "metabolites": {"ksii_core2_deg5_l": 1.0, "h2o_l": -3.0, "ksii_core4_deg3_l": -1.0, "acgam_l": 2.0, "h_l": 1.0, "so4_l": 1.0}, "id": "NACHEXA22ly", "gene_reaction_rule": "(3073_AT1 and 3074_AT1) or 3073_AT1"}, {"subsystem": "Chondroitin sulfate degradation", "name": "NACHEXA2ly", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NACHEXA2ly"]}, "metabolites": {"cs_b_deg2_l": 1.0, "acgal_l": 1.0, "h2o_l": -2.0, "cs_b_l": -1.0, "h_l": 1.0, "so4_l": 1.0}, "id": "NACHEXA2ly", "gene_reaction_rule": "(3073_AT1 and 3074_AT1) or 3073_AT1"}, {"subsystem": "Chondroitin sulfate degradation", "name": "NACHEXA3ly", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NACHEXA3ly"]}, "metabolites": {"acgal_l": 1.0, "cs_c_l": -1.0, "h2o_l": -2.0, "cs_c_deg2_l": 1.0, "h_l": 1.0, "so4_l": 1.0}, "id": "NACHEXA3ly", "gene_reaction_rule": "(3073_AT1 and 3074_AT1) or 3073_AT1"}, {"subsystem": "Chondroitin sulfate degradation", "name": "NACHEXA4ly", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NACHEXA4ly"]}, "metabolites": {"acgal_l": 1.0, "cs_c_deg5_l": 1.0, "h2o_l": -2.0, "cs_c_deg3_l": -1.0, "h_l": 1.0, "so4_l": 1.0}, "id": "NACHEXA4ly", "gene_reaction_rule": "(3073_AT1 and 3074_AT1) or 3073_AT1"}, {"subsystem": "Chondroitin sulfate degradation", "name": "NACHEXA5ly", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NACHEXA5ly"]}, "metabolites": {"cs_d_l": -1.0, "acgal_l": 1.0, "cs_d_deg2_l": 1.0, "h2o_l": -2.0, "h_l": 1.0, "so4_l": 1.0}, "id": "NACHEXA5ly", "gene_reaction_rule": "(3073_AT1 and 3074_AT1) or 3073_AT1"}, {"subsystem": "Chondroitin sulfate degradation", "name": "NACHEXA6ly", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NACHEXA6ly"]}, "metabolites": {"acgal_l": 1.0, "h2o_l": -2.0, "cs_d_deg6_l": 1.0, "cs_d_deg4_l": -1.0, "h_l": 1.0, "so4_l": 1.0}, "id": "NACHEXA6ly", "gene_reaction_rule": "(3073_AT1 and 3074_AT1) or 3073_AT1"}, {"subsystem": "Chondroitin sulfate degradation", "name": "NACHEXA7ly", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NACHEXA7ly"]}, "metabolites": {"cs_e_deg3_l": 1.0, "acgal_l": 1.0, "h2o_l": -3.0, "h_l": 2.0, "cs_e_l": -1.0, "so4_l": 2.0}, "id": "NACHEXA7ly", "gene_reaction_rule": "(3073_AT1 and 3074_AT1) or 3073_AT1"}, {"subsystem": "Chondroitin sulfate degradation", "name": "NACHEXA8ly", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NACHEXA8ly"]}, "metabolites": {"acgal_l": 1.0, "h2o_l": -3.0, "cs_e_deg4_l": -1.0, "cs_e_deg7_l": 1.0, "h_l": 2.0, "so4_l": 2.0}, "id": "NACHEXA8ly", "gene_reaction_rule": "(3073_AT1 and 3074_AT1) or 3073_AT1"}, {"subsystem": "Keratan sulfate degradation", "name": "NACHEXA9ly", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NACHEXA9ly"]}, "metabolites": {"ksi_deg6_l": -1.0, "h2o_l": -3.0, "acgam_l": 2.0, "h_l": 1.0, "ksi_deg8_l": 1.0, "so4_l": 1.0}, "id": "NACHEXA9ly", "gene_reaction_rule": "(3073_AT1 and 3074_AT1) or 3073_AT1"}, {"subsystem": "Transport, Extracellular", "name": "Nicotinic acid transport", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NACUP"]}, "metabolites": {"nac_e": -1.0, "nac_c": 1.0}, "id": "NACt", "gene_reaction_rule": ""}, {"subsystem": "Oxidative Phosphorylation", "name": "NADH2 u10m", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADH2_u10m"]}, "metabolites": {"q10h2_m": 1.0, "h_c": 4.0, "nad_m": 1.0, "q10_m": -1.0, "h_m": -5.0, "nadh_m": -1.0}, "id": "NADH2_u10m", "gene_reaction_rule": "(4715_AT1 and 4720_AT1 and 4719_AT1 and 4700_AT1 and 55967_AT1 and 4709_AT1 and 4710_AT1 and 4726_AT1 and 4718_AT1 and 4696_AT1 and 4694_AT1 and 374291_AT1 and 4728_AT1 and 4712_AT2 and 4717_AT1 and 4705_AT1 and 4725_AT1 and 4716_AT1 and 4537_AT1 and 7991_AT1 and 4722_AT1 and 4541_AT1 and 4539_AT1 and 4707_AT1 and 4701_AT1 and 4723_AT1 and 4698_AT1 and 4538_AT1 and 4697_AT1 and 51079_AT1 and 4714_AT1 and 4704_AT1 and 126328_AT1 and 4711_AT1 and 4724_AT1 and 4713_AT1 and 4536_AT1 and 4695_AT1 and 4702_AT1 and 4708_AT1 and 4535_AT1 and 4731_AT2 and 4706_AT1 and 4729_AT1 and 4540_AT1) or (4715_AT1 and 4720_AT1 and 4719_AT1 and 55967_AT1 and 4700_AT1 and 4709_AT1 and 4710_AT1 and 4726_AT1 and 4696_AT1 and 4718_AT1 and 4694_AT1 and 374291_AT1 and 4728_AT1 and 7991_AT2 and 4717_AT1 and 4731_AT1 and 4705_AT1 and 4725_AT1 and 4716_AT1 and 4537_AT1 and 4722_AT1 and 4541_AT1 and 4712_AT1 and 4539_AT1 and 4707_AT1 and 4701_AT1 and 4698_AT1 and 4723_AT1 and 4538_AT1 and 4697_AT1 and 51079_AT1 and 4714_AT1 and 4704_AT1 and 126328_AT1 and 4711_AT1 and 4724_AT1 and 4536_AT1 and 4713_AT1 and 4695_AT1 and 4702_AT1 and 4708_AT1 and 4706_AT1 and 4535_AT1 and 4540_AT1 and 4729_AT1) or (4715_AT1 and 4720_AT1 and 4719_AT1 and 55967_AT1 and 4700_AT1 and 4709_AT1 and 4710_AT1 and 4726_AT1 and 4718_AT1 and 4696_AT1 and 374291_AT1 and 4694_AT1 and 4728_AT1 and 7991_AT2 and 4712_AT2 and 4717_AT1 and 4705_AT1 and 4725_AT1 and 4716_AT1 and 4537_AT1 and 4722_AT1 and 4541_AT1 and 4539_AT1 and 4707_AT1 and 4701_AT1 and 4698_AT1 and 4723_AT1 and 4538_AT1 and 4697_AT1 and 51079_AT1 and 4714_AT1 and 4704_AT1 and 4711_AT1 and 126328_AT1 and 4724_AT1 and 4536_AT1 and 4713_AT1 and 4695_AT1 and 4702_AT1 and 4708_AT1 and 4731_AT2 and 4706_AT1 and 4535_AT1 and 4540_AT1 and 4729_AT1) or (4715_AT1 and 4720_AT1 and 4719_AT1 and 4700_AT1 and 55967_AT1 and 4709_AT1 and 4710_AT1 and 4726_AT1 and 4718_AT1 and 4696_AT1 and 374291_AT1 and 4694_AT1 and 4728_AT1 and 4717_AT1 and 4705_AT1 and 4725_AT1 and 4537_AT1 and 4716_AT1 and 4722_AT1 and 7991_AT1 and 4541_AT1 and 4712_AT1 and 4539_AT1 and 4707_AT1 and 4701_AT1 and 4723_AT1 and 4698_AT1 and 4538_AT1 and 4697_AT1 and 51079_AT1 and 4714_AT1 and 4704_AT1 and 4711_AT1 and 126328_AT1 and 4724_AT1 and 4713_AT1 and 4536_AT1 and 4695_AT1 and 4702_AT1 and 4708_AT1 and 4706_AT1 and 4535_AT1 and 4731_AT2 and 4729_AT1 and 4540_AT1) or (4715_AT1 and 4720_AT1 and 4719_AT1 and 55967_AT1 and 4700_AT1 and 4709_AT1 and 4710_AT1 and 4726_AT1 and 4696_AT1 and 4718_AT1 and 4694_AT1 and 374291_AT1 and 4728_AT1 and 4717_AT1 and 4731_AT1 and 4705_AT1 and 4725_AT1 and 4716_AT1 and 4537_AT1 and 4722_AT1 and 7991_AT1 and 4541_AT1 and 4539_AT1 and 4712_AT1 and 4707_AT1 and 4701_AT1 and 4723_AT1 and 4698_AT1 and 4538_AT1 and 4697_AT1 and 51079_AT1 and 4714_AT1 and 4704_AT1 and 126328_AT1 and 4711_AT1 and 4724_AT1 and 4713_AT1 and 4536_AT1 and 4695_AT1 and 4702_AT1 and 4708_AT1 and 4706_AT1 and 4535_AT1 and 4540_AT1 and 4729_AT1) or (4715_AT1 and 4720_AT1 and 4719_AT1 and 55967_AT1 and 4700_AT1 and 4709_AT1 and 4710_AT1 and 4726_AT1 and 4696_AT1 and 4718_AT1 and 374291_AT1 and 4694_AT1 and 4728_AT1 and 4712_AT2 and 4717_AT1 and 4731_AT1 and 4705_AT1 and 4725_AT1 and 4537_AT1 and 4716_AT1 and 4722_AT1 and 7991_AT1 and 4541_AT1 and 4539_AT1 and 4707_AT1 and 4701_AT1 and 4723_AT1 and 4698_AT1 and 4538_AT1 and 4697_AT1 and 51079_AT1 and 4714_AT1 and 4704_AT1 and 126328_AT1 and 4711_AT1 and 4724_AT1 and 4713_AT1 and 4536_AT1 and 4695_AT1 and 4702_AT1 and 4708_AT1 and 4535_AT1 and 4706_AT1 and 4729_AT1 and 4540_AT1) or (4715_AT1 and 4720_AT1 and 4719_AT1 and 4700_AT1 and 55967_AT1 and 4709_AT1 and 4710_AT1 and 4726_AT1 and 4718_AT1 and 4696_AT1 and 4694_AT1 and 374291_AT1 and 4728_AT1 and 7991_AT2 and 4717_AT1 and 4705_AT1 and 4725_AT1 and 4537_AT1 and 4716_AT1 and 4722_AT1 and 4541_AT1 and 4712_AT1 and 4539_AT1 and 4707_AT1 and 4701_AT1 and 4723_AT1 and 4698_AT1 and 4538_AT1 and 4697_AT1 and 51079_AT1 and 4714_AT1 and 4704_AT1 and 4711_AT1 and 126328_AT1 and 4724_AT1 and 4713_AT1 and 4536_AT1 and 4695_AT1 and 4702_AT1 and 4708_AT1 and 4535_AT1 and 4731_AT2 and 4706_AT1 and 4540_AT1 and 4729_AT1) or (4715_AT1 and 4720_AT1 and 4719_AT1 and 4700_AT1 and 55967_AT1 and 4709_AT1 and 4710_AT1 and 4726_AT1 and 4718_AT1 and 4696_AT1 and 374291_AT1 and 4694_AT1 and 4728_AT1 and 7991_AT2 and 4712_AT2 and 4717_AT1 and 4731_AT1 and 4705_AT1 and 4725_AT1 and 4537_AT1 and 4716_AT1 and 4722_AT1 and 4541_AT1 and 4539_AT1 and 4707_AT1 and 4701_AT1 and 4698_AT1 and 4723_AT1 and 4538_AT1 and 4697_AT1 and 51079_AT1 and 4714_AT1 and 4704_AT1 and 4711_AT1 and 126328_AT1 and 4724_AT1 and 4713_AT1 and 4536_AT1 and 4695_AT1 and 4702_AT1 and 4708_AT1 and 4706_AT1 and 4535_AT1 and 4540_AT1 and 4729_AT1)"}, {"subsystem": "Transport, Peroxisomal", "name": "NADHtpu", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADHtpu"]}, "metabolites": {"nadh_x": 1.0, "nadh_c": -1.0}, "id": "NADHtpu", "gene_reaction_rule": ""}, {"subsystem": "Transport, Endoplasmic Reticular", "name": "NADHtru", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADHtru"]}, "metabolites": {"nadh_r": 1.0, "nadh_c": -1.0}, "id": "NADHtru", "gene_reaction_rule": ""}, {"subsystem": "NAD Metabolism", "name": "NAD kinase", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADK"]}, "metabolites": {"h_c": 1.0, "nadp_c": 1.0, "nad_c": -1.0, "atp_c": -1.0, "adp_c": 1.0}, "id": "NADK", "gene_reaction_rule": "65220_AT1"}, {"subsystem": "NAD Metabolism", "name": "NAD nucleosidase", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADN"]}, "metabolites": {"h_c": 1.0, "h2o_c": -1.0, "nad_c": -1.0, "adprib_c": 1.0, "ncam_c": 1.0}, "id": "NADN", "gene_reaction_rule": ""}, {"subsystem": "NAD Metabolism", "name": "NADNe", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADNe"]}, "metabolites": {"adprib_e": 1.0, "ncam_e": 1.0, "h_e": 1.0, "h2o_e": -1.0, "nad_e": -1.0}, "id": "NADNe", "gene_reaction_rule": "952_AT1"}, {"subsystem": "Transport, Endoplasmic Reticular", "name": "NADPHtru", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADPHtru"]}, "metabolites": {"nadph_c": -1.0, "nadph_r": 1.0}, "id": "NADPHtru", "gene_reaction_rule": ""}, {"subsystem": "Transport, Peroxisomal", "name": "NADPHtxu", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADPHtxu"]}, "metabolites": {"nadph_c": -1.0, "nadph_x": 1.0}, "id": "NADPHtxu", "gene_reaction_rule": ""}, {"subsystem": "NAD Metabolism", "name": "NADPN", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADPN"]}, "metabolites": {"adprbp_c": 1.0, "nadp_c": -1.0, "h_c": 1.0, "h2o_c": -1.0, "ncam_c": 1.0}, "id": "NADPN", "gene_reaction_rule": ""}, {"subsystem": "NAD Metabolism", "name": "NADPNe", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADPNe"]}, "metabolites": {"ncam_e": 1.0, "adprbp_e": 1.0, "h2o_e": -1.0, "nadp_e": -1.0, "h_e": 1.0}, "id": "NADPNe", "gene_reaction_rule": "952_AT1"}, {"subsystem": "Transport, Endoplasmic Reticular", "name": "NADPtru", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADPtru"]}, "metabolites": {"nadp_r": -1.0, "nadp_c": 1.0}, "id": "NADPtru", "gene_reaction_rule": ""}, {"subsystem": "Transport, Peroxisomal", "name": "NADPtxu", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADPtxu"]}, "metabolites": {"nadp_x": -1.0, "nadp_c": 1.0}, "id": "NADPtxu", "gene_reaction_rule": ""}, {"subsystem": "NAD Metabolism", "name": "Nicotinate-mononucleotide adenylyltransferase", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADS2"]}, "metabolites": {"dnad_c": -1.0, "h2o_c": -1.0, "atp_c": -1.0, "ppi_c": 1.0, "amp_c": 1.0, "nad_c": 1.0, "gln__L_c": -1.0, "glu__L_c": 1.0, "h_c": 1.0}, "id": "NADS2", "gene_reaction_rule": "55191_AT1"}, {"subsystem": "Transport, Nuclear", "name": "NAD transport nuclear through pores", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["NADtn"]}, "metabolites": {"nad_n": -1.0, "nad_c": 1.0}, "id": "NADtn", "gene_reaction_rule": ""}, {"subsystem": "Transport, Peroxisomal", "name": "NADtpu", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADtpu"]}, "metabolites": {"nadh_x": -1.0, "nadh_c": 1.0}, "id": "NADtpu", "gene_reaction_rule": ""}, {"subsystem": "Transport, Endoplasmic Reticular", "name": "NADtru", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADtru"]}, "metabolites": {"nad_c": 1.0, "nad_r": -1.0}, "id": "NADtru", "gene_reaction_rule": ""}, {"subsystem": "Keratan sulfate degradation", "name": "NAGA2ly", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NAGA2ly"]}, "metabolites": {"udpacgal_l": 1.0, "Ser_Thr_l": 1.0, "h_l": -1.0, "Tn_antigen_l": -1.0, "udp_l": -1.0}, "id": "NAGA2ly", "gene_reaction_rule": "4668_AT1"}, {"subsystem": "Sphingolipid Metabolism", "name": "NAGAlby", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NAGAlby"]}, "metabolites": {"udpacgal_l": 1.0, "acgbgbside_hs_l": -1.0, "h_l": -1.0, "gbside_hs_l": 1.0, "udp_l": -1.0}, "id": "NAGAlby", "gene_reaction_rule": ""}, {"subsystem": "Sphingolipid Metabolism", "name": "NAGAly", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NAGAly"]}, "metabolites": {"udpacgal_l": 1.0, "acgagbside_hs_l": -1.0, "h_l": -1.0, "gbside_hs_l": 1.0, "udp_l": -1.0}, "id": "NAGAly", "gene_reaction_rule": "4668_AT1"}, {"subsystem": "Keratan sulfate degradation", "name": "NAGLCAly", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NAGLCAly"]}, "metabolites": {"acgam_l": 1.0, "Tn_antigen_l": 1.0, "h2o_l": -1.0, "core6_l": -1.0}, "id": "NAGLCAly", "gene_reaction_rule": ""}, {"subsystem": "Transport, Extracellular", "name": "NAHCO3 HCLt", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["NAHCO3_HCLt"]}, "metabolites": {"hco3_c": 1.0, "na1_c": 1.0, "na1_e": -1.0, "hco3_e": -1.0, "cl_e": 1.0, "h_e": 1.0, "h_c": -1.0, "cl_c": -1.0}, "id": "NAHCO3_HCLt", "gene_reaction_rule": "9498_AT1 or 57282_AT1"}, {"subsystem": "Transport, Extracellular", "name": "NAIt", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["NAIt"]}, "metabolites": {"i_e": -1.0, "na1_c": 2.0, "i_c": 1.0, "na1_e": -2.0}, "id": "NAIt", "gene_reaction_rule": "6528_AT1"}, {"subsystem": "Transport, Extracellular", "name": "NAt", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["NAt"]}, "metabolites": {"na1_c": 1.0, "na1_e": -1.0}, "id": "NAt", "gene_reaction_rule": "6526_AT1 or 6523_AT1 or 6528_AT1"}, {"subsystem": "Transport, Extracellular", "name": "Sodium proton antiporter HNA is 11 ", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["NAt3_1"]}, "metabolites": {"na1_c": -1.0, "h_e": -1.0, "na1_e": 1.0, "h_c": 1.0}, "id": "NAt3_1", "gene_reaction_rule": "389015_AT1 or 6549_AT1 or 6548_AT1 or 6550_AT1 or 6553_AT1"}, {"subsystem": "Transport, Golgi Apparatus", "name": "NAt3 1g", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["NAt3_1g"]}, "metabolites": {"h_g": -1.0, "na1_c": -1.0, "h_c": 1.0, "na1_g": 1.0}, "id": "NAt3_1g", "gene_reaction_rule": "84679_AT1 or 23315_AT1"}, {"subsystem": "Transport, Extracellular", "name": "NAt5", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["NAt5"]}, "metabolites": {"na1_c": -1.0, "nh4_e": -1.0, "nh4_c": 1.0, "na1_e": 1.0}, "id": "NAt5", "gene_reaction_rule": "6549_AT1 or 6548_AT1 or 6550_AT1"}, {"subsystem": "Transport, Peroxisomal", "name": "NAtx", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["NAtx"]}, "metabolites": {"na1_x": 1.0, "na1_c": -1.0}, "id": "NAtx", "gene_reaction_rule": ""}, {"subsystem": "beta-Alanine metabolism", "name": "NBAHH ir", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NBAHH_ir"]}, "metabolites": {"carn_c": -1.0, "his__L_c": 1.0, "h2o_c": -1.0, "ala_B_c": 1.0}, "id": "NBAHH_ir", "gene_reaction_rule": "84735_AT1"}, {"subsystem": "Transport, Extracellular", "name": "Nicotinamide acid uptake", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NCAMUP"]}, "metabolites": {"ncam_e": -1.0, "ncam_c": 1.0}, "id": "NCAMUP", "gene_reaction_rule": ""}, {"subsystem": "Transport, Extracellular", "name": "NCCt", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NCCt"]}, "metabolites": {"cl_e": -1.0, "na1_c": 1.0, "na1_e": -1.0, "cl_c": 1.0}, "id": "NCCt", "gene_reaction_rule": "6559_AT1"}, {"subsystem": "Transport, Extracellular", "name": "NCKt", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["NCKt"]}, "metabolites": {"ca2_e": -1.0, "ca2_c": 1.0, "na1_c": -4.0, "na1_e": 4.0, "k_c": 1.0, "k_e": -1.0}, "id": "NCKt", "gene_reaction_rule": "123041_AT2 or 57419_AT1 or 9187_AT1 or 123041_AT3 or 25769_AT1 or 123041_AT1"}, {"subsystem": "Transport, Extracellular", "name": "NCNt", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["NCNt"]}, "metabolites": {"ca2_e": -1.0, "ca2_c": 1.0, "na1_c": -4.0, "na1_e": 4.0, "nh4_e": -1.0, "nh4_c": 1.0}, "id": "NCNt", "gene_reaction_rule": "9187_AT1 or 25769_AT1"}, {"subsystem": "Nucleotides", "name": "NDP10ex", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NDP10ex"]}, "metabolites": {"idp_e": -1.0, "imp_e": 1.0, "h_e": 1.0, "h2o_e": -1.0, "pi_e": 1.0}, "id": "NDP10ex", "gene_reaction_rule": "124583_AT1"}, {"subsystem": "Nucleotides", "name": "NDP3ex", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NDP3ex"]}, "metabolites": {"gdp_e": -1.0, "h_e": 1.0, "h2o_e": -1.0, "gmp_e": 1.0, "pi_e": 1.0}, "id": "NDP3ex", "gene_reaction_rule": "124583_AT1"}, {"subsystem": "Nucleotides", "name": "NDP6", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NDP6"]}, "metabolites": {"dcmp_c": 1.0, "h2o_c": -1.0, "pi_c": 1.0, "h_c": 1.0, "dcdp_c": -1.0}, "id": "NDP6", "gene_reaction_rule": ""}, {"subsystem": "Nucleotides", "name": "NDP7er", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NDP7er"]}, "metabolites": {"ump_r": 1.0, "pi_r": 1.0, "h2o_r": -1.0, "h_r": 1.0, "udp_r": -1.0}, "id": "NDP7er", "gene_reaction_rule": ""}, {"subsystem": "Nucleotides", "name": "NDP7ex", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NDP7ex"]}, "metabolites": {"h2o_e": -1.0, "h_e": 1.0, "udp_e": -1.0, "pi_e": 1.0, "ump_e": 1.0}, "id": "NDP7ex", "gene_reaction_rule": "124583_AT1"}, {"subsystem": "Nucleotides", "name": "NDP7g", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NDP7g"]}, "metabolites": {"udp_g": -1.0, "h_g": 1.0, "ump_g": 1.0, "h2o_g": -1.0, "pi_g": 1.0}, "id": "NDP7g", "gene_reaction_rule": "9583_AT1"}, {"subsystem": "Nucleotides", "name": "NDP8", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NDP8"]}, "metabolites": {"h2o_c": -1.0, "pi_c": 1.0, "dudp_c": -1.0, "dump_c": 1.0, "h_c": 1.0}, "id": "NDP8", "gene_reaction_rule": "1841_AT1"}, {"subsystem": "Nucleotides", "name": "NDP8ex", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NDP8ex"]}, "metabolites": {"h2o_e": -1.0, "h_e": 1.0, "udp_e": 1.0, "pi_e": 1.0, "utp_e": -1.0}, "id": "NDP8ex", "gene_reaction_rule": "124583_AT1"}, {"subsystem": "Nucleotides", "name": "Nucleoside-diphosphate kinase (ATP:GDP)", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["NDPK1"]}, "metabolites": {"gtp_c": 1.0, "gdp_c": -1.0, "atp_c": -1.0, "adp_c": 1.0}, "id": "NDPK1", "gene_reaction_rule": "4832_AT1 or 10201_AT1 or (4831_AT1 and 4830_AT1) or 29922_AT2 or (4830_AT2 and 4831_AT1) or 29922_AT1"}, {"subsystem": "Nucleotides", "name": "Nucleoside-diphosphate kinase (ATP dIDP)", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["NDPK10"]}, "metabolites": {"ditp_c": 1.0, "adp_c": 1.0, "atp_c": -1.0, "didp_c": -1.0}, "id": "NDPK10", "gene_reaction_rule": "(4830_AT2 and 4831_AT1) or 4832_AT1 or 10201_AT1 or 29922_AT2 or 29922_AT1 or (4831_AT1 and 4830_AT1)"}, {"subsystem": "Nucleotides", "name": "NDPK10m", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["NDPK10m"]}, "metabolites": {"adp_m": 1.0, "atp_m": -1.0, "ditp_m": 1.0, "didp_m": -1.0}, "id": "NDPK10m", "gene_reaction_rule": "4833_AT1"}, {"subsystem": "Nucleotides", "name": "NDPK10n", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["NDPK10n"]}, "metabolites": {"didp_n": -1.0, "atp_n": -1.0, "ditp_n": 1.0, "adp_n": 1.0}, "id": "NDPK10n", "gene_reaction_rule": "(4831_AT1 and 4830_AT1) or (4830_AT2 and 4831_AT1)"}, {"subsystem": "Nucleotides", "name": "NDPK1m", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["NDPK1m"]}, "metabolites": {"atp_m": -1.0, "adp_m": 1.0, "gdp_m": -1.0, "gtp_m": 1.0}, "id": "NDPK1m", "gene_reaction_rule": "4833_AT1"}, {"subsystem": "Nucleotides", "name": "NDPK1n", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["NDPK1n"]}, "metabolites": {"gdp_n": -1.0, "adp_n": 1.0, "atp_n": -1.0, "gtp_n": 1.0}, "id": "NDPK1n", "gene_reaction_rule": "(4831_AT1 and 4830_AT1) or (4830_AT2 and 4831_AT1)"}, {"subsystem": "Nucleotides", "name": "Nucleoside-diphosphate kinase (ATP:UDP)", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["NDPK2"]}, "metabolites": {"udp_c": -1.0, "utp_c": 1.0, "atp_c": -1.0, "adp_c": 1.0}, "id": "NDPK2", "gene_reaction_rule": "4832_AT1 or 29922_AT1 or (4831_AT1 and 4830_AT1) or 10201_AT1 or (4830_AT2 and 4831_AT1) or 29922_AT2"}, {"subsystem": "Nucleotides", "name": "NDPK2m", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["NDPK2m"]}, "metabolites": {"atp_m": -1.0, "adp_m": 1.0, "utp_m": 1.0, "udp_m": -1.0}, "id": "NDPK2m", "gene_reaction_rule": "4833_AT1"}, {"subsystem": "Nucleotides", "name": "NDPK2n", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["NDPK2n"]}, "metabolites": {"utp_n": 1.0, "adp_n": 1.0, "atp_n": -1.0, "udp_n": -1.0}, "id": "NDPK2n", "gene_reaction_rule": "(4831_AT1 and 4830_AT1) or (4830_AT2 and 4831_AT1)"}, {"subsystem": "Nucleotides", "name": "Nucleoside-diphosphate kinase (ATP:CDP)", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["NDPK3"]}, "metabolites": {"ctp_c": 1.0, "cdp_c": -1.0, "atp_c": -1.0, "adp_c": 1.0}, "id": "NDPK3", "gene_reaction_rule": "(4830_AT2 and 4831_AT1) or 29922_AT2 or (4831_AT1 and 4830_AT1) or 29922_AT1 or 10201_AT1 or 4832_AT1"}, {"subsystem": "Nucleotides", "name": "NDPK3m", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["NDPK3m"]}, "metabolites": {"atp_m": -1.0, "adp_m": 1.0, "cdp_m": -1.0, "ctp_m": 1.0}, "id": "NDPK3m", "gene_reaction_rule": "4833_AT1"}, {"subsystem": "Nucleotides", "name": "NDPK3n", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": 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"PI45PLCn", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PI45PLCn"]}, "metabolites": {"h_n": 1.0, "mi145p_n": 1.0, "dag_hs_n": 1.0, "pail45p_hs_n": -1.0, "h2o_n": -1.0}, "id": "PI45PLCn", "gene_reaction_rule": "23236_AT1 or 23236_AT2"}, {"subsystem": "Inositol Phosphate Metabolism", "name": "PI4P3K", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PI4P3K"]}, "metabolites": {"h_c": 1.0, "pail34p_hs_c": 1.0, "adp_c": 1.0, "atp_c": -1.0, "pail4p_hs_c": -1.0}, "id": "PI4P3K", "gene_reaction_rule": "(5291_AT1 and 5295_AT3) or (5296_AT1 and 5290_AT1) or (5293_AT1 and 5296_AT1) or 5287_AT1 or 5286_AT1 or (5293_AT1 and 8503_AT1) or (5293_AT1 and 5295_AT3) or (5291_AT1 and 8503_AT1) or (5295_AT2 and 5290_AT1) or 5288_AT1 or (5291_AT1 and 5295_AT1) or (5296_AT1 and 5291_AT1) or (23533_AT1 and 5294_AT1) or (5293_AT1 and 5295_AT1) or (5295_AT2 and 5293_AT1) or (5290_AT1 and 8503_AT1) or (5290_AT1 and 5295_AT3) or (10870_AT1 and 5294_AT1) or (5295_AT2 and 5291_AT1) or (5290_AT1 and 5295_AT1)"}, {"subsystem": "Inositol Phosphate Metabolism", "name": "PI4P3Ker", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PI4P3Ker"]}, "metabolites": {"pail34p_hs_r": 1.0, "atp_r": -1.0, "h_r": 1.0, "pail4p_hs_r": -1.0, "adp_r": 1.0}, "id": "PI4P3Ker", "gene_reaction_rule": "5287_AT1"}, {"subsystem": "Inositol Phosphate Metabolism", "name": "PI4P3Kn", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PI4P3Kn"]}, "metabolites": {"h_n": 1.0, "pail4p_hs_n": -1.0, "adp_n": 1.0, "pail34p_hs_n": 1.0, "atp_n": -1.0}, "id": "PI4P3Kn", "gene_reaction_rule": ""}, {"subsystem": "Inositol Phosphate Metabolism", "name": "PI4P4Pn", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PI4P4Pn"]}, "metabolites": {"pail4p_hs_n": -1.0, "pail_hs_n": 1.0, "pi_n": 1.0, "h2o_n": -1.0}, "id": "PI4P4Pn", "gene_reaction_rule": ""}, {"subsystem": "Glycerophospholipid Metabolism", "name": "PI4P5K", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PI4P5K"]}, "metabolites": {"pail45p_hs_c": 1.0, "pail4p_hs_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "atp_c": -1.0}, "id": "PI4P5K", "gene_reaction_rule": "200576_AT2 or 8396_AT1 or 200576_AT3 or 79837_AT1 or 8394_AT1 or 23396_AT1 or 8395_AT1 or 8396_AT2 or 5305_AT1 or 200576_AT1"}, {"subsystem": "Inositol Phosphate Metabolism", "name": "PI4P5Kn", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PI4P5Kn"]}, "metabolites": {"h_n": 1.0, "pail4p_hs_n": -1.0, "adp_n": 1.0, "pail45p_hs_n": 1.0, "atp_n": -1.0}, "id": "PI4P5Kn", "gene_reaction_rule": ""}, {"subsystem": "Inositol Phosphate Metabolism", "name": "PI4PLC", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PI4PLC"]}, "metabolites": {"h_c": 1.0, "dag_hs_c": 1.0, "mi14p_c": 1.0, "h2o_c": -1.0, "pail4p_hs_c": -1.0}, "id": "PI4PLC", "gene_reaction_rule": "23236_AT1 or 51196_AT1 or 9651_AT1 or 113026_AT1 or 89869_AT1 or 23007_AT1 or 5334_AT1 or 5331_AT1 or 5333_AT1 or 257068_AT1 or 5332_AT1 or 23236_AT2 or 5335_AT1 or 5335_AT2 or 5336_AT1 or 5330_AT1 or 5332_AT2 or 84812_AT1"}, {"subsystem": "Inositol Phosphate Metabolism", "name": "PI4PLCn", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PI4PLCn"]}, "metabolites": {"h_n": 1.0, "pail4p_hs_n": -1.0, "mi14p_n": 1.0, "dag_hs_n": 1.0, "h2o_n": -1.0}, "id": "PI4PLCn", "gene_reaction_rule": "23236_AT2 or 23236_AT1"}, {"subsystem": "Inositol Phosphate Metabolism", "name": "PI4PP", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PI4PP"]}, "metabolites": {"pail_hs_c": 1.0, "h2o_c": -1.0, "pi_c": 1.0, "pail4p_hs_c": -1.0}, "id": "PI4PP", "gene_reaction_rule": ""}, {"subsystem": "Inositol Phosphate Metabolism", "name": "PI5P3K", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PI5P3K"]}, "metabolites": {"pail35p_hs_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "pail5p_hs_c": -1.0, "atp_c": -1.0}, "id": "PI5P3K", "gene_reaction_rule": "(5295_AT2 and 5291_AT1) or (23533_AT1 and 5294_AT1) or (5295_AT2 and 5290_AT1) or (5293_AT1 and 5295_AT3) or 5287_AT1 or 5286_AT1 or (5293_AT1 and 5296_AT1) or (5295_AT2 and 5293_AT1) or (5296_AT1 and 5291_AT1) or (5290_AT1 and 5295_AT1) or 5288_AT1 or (5290_AT1 and 8503_AT1) or (5291_AT1 and 5295_AT3) or (10870_AT1 and 5294_AT1) or (5291_AT1 and 8503_AT1) or (5293_AT1 and 5295_AT1) or (5296_AT1 and 5290_AT1) or 5289_AT1 or (5293_AT1 and 8503_AT1) or (5291_AT1 and 5295_AT1) or (5290_AT1 and 5295_AT3)"}, {"subsystem": "Inositol Phosphate Metabolism", "name": "PI5P3Ker", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PI5P3Ker"]}, "metabolites": {"pail35p_hs_r": 1.0, "pail5p_hs_r": -1.0, "atp_r": -1.0, "h_r": 1.0, "adp_r": 1.0}, "id": "PI5P3Ker", "gene_reaction_rule": "5287_AT1"}, {"subsystem": "Inositol Phosphate Metabolism", "name": "PI5P4K", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PI5P4K"]}, "metabolites": {"pail45p_hs_c": 1.0, "pail5p_hs_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "atp_c": -1.0}, "id": "PI5P4K", "gene_reaction_rule": "5297_AT1 or 55361_AT1 or 5298_AT1"}, {"subsystem": "Inositol Phosphate Metabolism", "name": "PI5P4Kn", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PI5P4Kn"]}, "metabolites": {"h_n": 1.0, "atp_n": -1.0, "pail5p_hs_n": -1.0, "pail45p_hs_n": 1.0, "adp_n": 1.0}, "id": "PI5P4Kn", "gene_reaction_rule": ""}, {"subsystem": "Glycosylphosphatidylinositol (GPI)-anchor biosynthesis", "name": "PIACGT", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PIACGT"]}, "metabolites": {"uacgam_c": -1.0, "pail_hs_c": -1.0, "udp_c": 1.0, "h_c": 1.0, "acgpail_hs_c": 1.0}, "id": "PIACGT", "gene_reaction_rule": "(5279_AT1 and 51227_AT2 and 5283_AT1 and 5277_AT2 and 9091_AT1 and 8818_AT1) or (5279_AT1 and 51227_AT2 and 5283_AT1 and 9091_AT1 and 5277_AT2 and 8818_AT1) or (51227_AT1 and 9091_AT2 and 5277_AT3 and 5283_AT1 and 5279_AT2 and 8818_AT1) or (51227_AT2 and 5277_AT1 and 5283_AT1 and 9091_AT1 and 8818_AT2 and 5279_AT2) or (51227_AT3 and 9091_AT2 and 5277_AT3 and 5283_AT1 and 5279_AT2 and 8818_AT1) or (5279_AT1 and 51227_AT1 and 9091_AT2 and 5277_AT1 and 5283_AT1 and 8818_AT2) or (51227_AT3 and 9091_AT2 and 5277_AT1 and 5283_AT1 and 5279_AT2 and 8818_AT1) or (51227_AT1 and 9091_AT2 and 5277_AT1 and 5283_AT1 and 8818_AT1 and 5279_AT2) or (51227_AT3 and 9091_AT2 and 5277_AT3 and 5283_AT1 and 5279_AT2 and 8818_AT2) or (51227_AT1 and 5277_AT1 and 5283_AT1 and 9091_AT1 and 5279_AT2 and 8818_AT1) or (51227_AT2 and 5283_AT1 and 9091_AT1 and 5277_AT2 and 8818_AT1 and 5279_AT2) or (5279_AT1 and 51227_AT1 and 9091_AT2 and 5277_AT3 and 5283_AT1 and 8818_AT2) or (51227_AT3 and 9091_AT2 and 5277_AT1 and 5283_AT1 and 8818_AT2 and 5279_AT2) or (5279_AT1 and 51227_AT2 and 5277_AT3 and 5283_AT1 and 9091_AT1 and 8818_AT2) or (51227_AT1 and 5277_AT3 and 5283_AT1 and 9091_AT1 and 8818_AT1 and 5279_AT2) or (51227_AT2 and 5277_AT1 and 5283_AT1 and 9091_AT1 and 8818_AT1 and 5279_AT2) or (5279_AT1 and 51227_AT2 and 9091_AT2 and 5277_AT1 and 5283_AT1 and 8818_AT1) or (5279_AT1 and 51227_AT1 and 9091_AT2 and 5283_AT1 and 5277_AT2 and 8818_AT2) or (5279_AT1 and 9091_AT2 and 51227_AT2 and 5277_AT2 and 5283_AT1 and 8818_AT2) or (5279_AT1 and 9091_AT2 and 51227_AT2 and 5277_AT1 and 5283_AT1 and 8818_AT2) or (51227_AT3 and 5283_AT1 and 5277_AT2 and 9091_AT1 and 8818_AT1 and 5279_AT2) or (51227_AT2 and 5277_AT3 and 5283_AT1 and 9091_AT1 and 8818_AT1 and 5279_AT2) or (5279_AT1 and 51227_AT1 and 5283_AT1 and 5277_AT2 and 9091_AT1 and 8818_AT2) or (51227_AT3 and 9091_AT2 and 5283_AT1 and 5277_AT2 and 5279_AT2 and 8818_AT1) or (5279_AT1 and 51227_AT3 and 9091_AT2 and 5283_AT1 and 5277_AT2 and 8818_AT2) or (51227_AT1 and 9091_AT2 and 5277_AT3 and 5283_AT1 and 8818_AT2 and 5279_AT2) or (5279_AT1 and 51227_AT3 and 5277_AT3 and 5283_AT1 and 9091_AT1 and 8818_AT2) or (51227_AT1 and 5283_AT1 and 5277_AT2 and 9091_AT1 and 5279_AT2 and 8818_AT2) or (5279_AT1 and 51227_AT3 and 5277_AT1 and 5283_AT1 and 9091_AT1 and 8818_AT1) or (5279_AT1 and 51227_AT3 and 9091_AT2 and 5277_AT1 and 5283_AT1 and 8818_AT2) or (5279_AT1 and 51227_AT1 and 5277_AT3 and 5283_AT1 and 9091_AT1 and 8818_AT1) or (5279_AT1 and 51227_AT3 and 9091_AT2 and 5277_AT3 and 5283_AT1 and 8818_AT2) or (5279_AT1 and 51227_AT2 and 5277_AT3 and 9091_AT1 and 5283_AT1 and 8818_AT1) or (51227_AT2 and 5277_AT3 and 9091_AT1 and 5283_AT1 and 8818_AT2 and 5279_AT2) or (51227_AT2 and 9091_AT2 and 5277_AT2 and 5283_AT1 and 8818_AT1 and 5279_AT2) or (51227_AT1 and 9091_AT2 and 5277_AT1 and 5283_AT1 and 8818_AT2 and 5279_AT2) or (51227_AT1 and 5277_AT3 and 5283_AT1 and 9091_AT1 and 5279_AT2 and 8818_AT2) or (5279_AT1 and 51227_AT1 and 9091_AT2 and 5277_AT3 and 5283_AT1 and 8818_AT1) or (51227_AT2 and 9091_AT2 and 5277_AT3 and 5283_AT1 and 8818_AT1 and 5279_AT2) or (51227_AT3 and 5277_AT3 and 9091_AT1 and 5283_AT1 and 5279_AT2 and 8818_AT2) or (9091_AT2 and 51227_AT2 and 5277_AT3 and 5283_AT1 and 5279_AT2 and 8818_AT2) or (5279_AT1 and 9091_AT2 and 51227_AT2 and 5277_AT3 and 5283_AT1 and 8818_AT2) or (51227_AT1 and 5277_AT1 and 5283_AT1 and 9091_AT1 and 8818_AT2 and 5279_AT2) or (5279_AT1 and 9091_AT2 and 51227_AT2 and 5277_AT3 and 5283_AT1 and 8818_AT1) or (5279_AT1 and 51227_AT1 and 9091_AT2 and 5277_AT2 and 5283_AT1 and 8818_AT1) or (51227_AT3 and 5277_AT1 and 9091_AT1 and 5283_AT1 and 5279_AT2 and 8818_AT2) or (5279_AT1 and 51227_AT1 and 9091_AT1 and 5277_AT2 and 5283_AT1 and 8818_AT1) or (51227_AT1 and 5283_AT1 and 9091_AT1 and 5277_AT2 and 5279_AT2 and 8818_AT1) or (5279_AT1 and 51227_AT3 and 9091_AT2 and 5277_AT1 and 5283_AT1 and 8818_AT1) or (51227_AT3 and 5277_AT3 and 5283_AT1 and 9091_AT1 and 8818_AT1 and 5279_AT2) or (51227_AT3 and 5279_AT1 and 9091_AT2 and 5277_AT3 and 5283_AT1 and 8818_AT1) or (51227_AT3 and 9091_AT1 and 5283_AT1 and 5277_AT2 and 5279_AT2 and 8818_AT2) or (51227_AT3 and 5277_AT1 and 5283_AT1 and 9091_AT1 and 8818_AT1 and 5279_AT2) or (5279_AT1 and 51227_AT1 and 5277_AT3 and 5283_AT1 and 9091_AT1 and 8818_AT2) or (9091_AT2 and 51227_AT2 and 5277_AT1 and 5283_AT1 and 5279_AT2 and 8818_AT1) or (51227_AT1 and 9091_AT2 and 5277_AT2 and 5283_AT1 and 8818_AT1 and 5279_AT2) or (51227_AT2 and 5283_AT1 and 5277_AT2 and 9091_AT1 and 8818_AT2 and 5279_AT2) or (9091_AT2 and 51227_AT2 and 5277_AT1 and 5283_AT1 and 8818_AT2 and 5279_AT2) or (5279_AT1 and 51227_AT3 and 5277_AT1 and 5283_AT1 and 9091_AT1 and 8818_AT2) or (5279_AT1 and 51227_AT1 and 9091_AT2 and 5277_AT1 and 5283_AT1 and 8818_AT1) or (5279_AT1 and 51227_AT3 and 5277_AT3 and 5283_AT1 and 9091_AT1 and 8818_AT1) or (5279_AT1 and 51227_AT3 and 5283_AT1 and 5277_AT2 and 9091_AT1 and 8818_AT1) or (5279_AT1 and 51227_AT2 and 5277_AT1 and 9091_AT1 and 5283_AT1 and 8818_AT2) or (51227_AT3 and 9091_AT2 and 5283_AT1 and 5277_AT2 and 8818_AT2 and 5279_AT2) or (9091_AT2 and 51227_AT2 and 5283_AT1 and 5277_AT2 and 5279_AT2 and 8818_AT2) or (5279_AT1 and 51227_AT2 and 5277_AT1 and 9091_AT1 and 5283_AT1 and 8818_AT1) or (5279_AT1 and 51227_AT3 and 9091_AT2 and 5283_AT1 and 5277_AT2 and 8818_AT1) or (5279_AT1 and 51227_AT1 and 5277_AT1 and 5283_AT1 and 9091_AT1 and 8818_AT1) or (5279_AT1 and 9091_AT2 and 51227_AT2 and 5277_AT2 and 5283_AT1 and 8818_AT1) or (5279_AT1 and 51227_AT3 and 9091_AT1 and 5277_AT2 and 5283_AT1 and 8818_AT2) or (51227_AT1 and 9091_AT2 and 5283_AT1 and 5277_AT2 and 8818_AT2 and 5279_AT2) or (5279_AT1 and 51227_AT1 and 5277_AT1 and 9091_AT1 and 5283_AT1 and 8818_AT2)"}, {"subsystem": "Inositol Phosphate Metabolism", "name": "PIK3", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PIK3"]}, "metabolites": {"pail_hs_c": -1.0, "pail3p_hs_c": 1.0, "h_c": 1.0, "atp_c": -1.0, "adp_c": 1.0}, "id": "PIK3", "gene_reaction_rule": "(5295_AT2 and 5291_AT1) or (23533_AT1 and 5294_AT1) or (5290_AT1 and 5295_AT1) or (5293_AT1 and 5295_AT3) or 5287_AT1 or 5286_AT1 or (5293_AT1 and 5296_AT1) or (5295_AT2 and 5293_AT1) or (5296_AT1 and 5291_AT1) or (5290_AT1 and 5295_AT3) or 5288_AT1 or (5290_AT1 and 8503_AT1) or (5291_AT1 and 5295_AT3) or (10870_AT1 and 5294_AT1) or (5291_AT1 and 8503_AT1) or (5293_AT1 and 5295_AT1) or (5296_AT1 and 5290_AT1) or 5289_AT1 or (5293_AT1 and 8503_AT1) or (5291_AT1 and 5295_AT1) or (5295_AT2 and 5290_AT1)"}, {"subsystem": "Inositol Phosphate Metabolism", "name": "PIK3er", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PIK3er"]}, "metabolites": {"pail_hs_r": -1.0, "atp_r": -1.0, "h_r": 1.0, "pail3p_hs_r": 1.0, "adp_r": 1.0}, "id": "PIK3er", "gene_reaction_rule": "5287_AT1"}, {"subsystem": "Inositol Phosphate Metabolism", "name": "PIK3n", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PIK3n"]}, "metabolites": {"h_n": 1.0, "pail3p_hs_n": 1.0, "atp_n": -1.0, "pail_hs_n": -1.0, "adp_n": 1.0}, "id": "PIK3n", "gene_reaction_rule": ""}, {"subsystem": "Glycerophospholipid Metabolism", "name": "PIK4", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PIK4"]}, "metabolites": {"h_c": 1.0, "pail_hs_c": -1.0, "adp_c": 1.0, "atp_c": -1.0, "pail4p_hs_c": 1.0}, "id": "PIK4", "gene_reaction_rule": "5298_AT1 or 55361_AT1 or 5297_AT1"}, {"subsystem": "Inositol Phosphate Metabolism", "name": "PIK4n", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PIK4n"]}, "metabolites": {"h_n": 1.0, "pail4p_hs_n": 1.0, "atp_n": -1.0, "pail_hs_n": -1.0, "adp_n": 1.0}, "id": "PIK4n", "gene_reaction_rule": ""}, {"subsystem": "Inositol Phosphate Metabolism", "name": "PIK5", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PIK5"]}, "metabolites": {"pail_hs_c": -1.0, "atp_c": -1.0, "h_c": 1.0, "pail5p_hs_c": 1.0, "adp_c": 1.0}, "id": "PIK5", "gene_reaction_rule": "8394_AT1 or 23396_AT1 or 8395_AT1"}, {"subsystem": "Inositol Phosphate Metabolism", "name": "PIK5n", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PIK5n"]}, "metabolites": {"h_n": 1.0, "pail5p_hs_n": 1.0, "atp_n": -1.0, "pail_hs_n": -1.0, "adp_n": 1.0}, "id": "PIK5n", "gene_reaction_rule": ""}, {"subsystem": "Inositol Phosphate Metabolism", "name": "PIPLC", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PIPLC"]}, "metabolites": {"mi1p__D_c": 1.0, "h2o_c": -1.0, "pail_hs_c": -1.0, "dag_hs_c": 1.0, "h_c": 1.0}, "id": "PIPLC", "gene_reaction_rule": "23236_AT2 or 5336_AT1 or 23007_AT1 or 113026_AT1 or 89869_AT1 or 84812_AT1 or 9651_AT1 or 5335_AT1 or 51196_AT1 or 257068_AT1 or 5332_AT2 or 5331_AT1 or 5335_AT2 or 5334_AT1 or 5332_AT1 or 5330_AT1 or 23236_AT1 or 5333_AT1"}, {"subsystem": "Inositol Phosphate Metabolism", "name": "PIPLCn", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PIPLCn"]}, "metabolites": {"h_n": 1.0, "mi1p__D_n": 1.0, "pail_hs_n": -1.0, "dag_hs_n": 1.0, "h2o_n": -1.0}, "id": "PIPLCn", "gene_reaction_rule": "23236_AT2 or 23236_AT1"}, {"subsystem": "Transport, Mitochondrial", "name": "Phosphate transporter mitochondrial", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["PIt2m"]}, "metabolites": {"pi_c": -1.0, "h_m": 1.0, "h_c": -1.0, "pi_m": 1.0}, "id": "PIt2m", "gene_reaction_rule": "5250_AT4 or 5250_AT1 or 5250_AT3 or 5250_AT2"}, {"subsystem": "Transport, Extracellular", "name": "Phosphate transport in/out via three Na+ symporter", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["PIt7", "PIt7ir"]}, "metabolites": {"na1_c": 3.0, "pi_c": 1.0, "pi_e": -1.0, "na1_e": -3.0}, "id": "PIt7_copy1", "gene_reaction_rule": "6569_AT1 or 10568_AT1"}, {"subsystem": "Transport, Extracellular", "name": "Phosphate transport in/out via three Na+ symporter", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PIt7", "PIt7ir"]}, "metabolites": {"na1_c": 3.0, "pi_c": 1.0, "pi_e": -1.0, "na1_e": -3.0}, "id": "PIt7_copy2", "gene_reaction_rule": "10050_AT1 or 10786_AT1 or 10246_AT1 or 6568_AT1"}, {"subsystem": "Transport, Extracellular", "name": "PIt8", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["PIt8"]}, "metabolites": {"na1_c": 1.5, "pi_c": 1.0, "na1_e": -1.5, "pi_e": -1.0}, "id": "PIt8", "gene_reaction_rule": "6574_AT1 or 6575_AT1"}, {"subsystem": "Transport, Extracellular", "name": "PIt9", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["PIt9"]}, "metabolites": {"na1_c": 2.0, "pi_c": 1.0, "na1_e": -2.0, "pi_e": -1.0}, "id": "PIt9", "gene_reaction_rule": "142680_AT1"}, {"subsystem": "Transport, Endoplasmic Reticular", "name": "PIter", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["PIter"]}, "metabolites": {"pi_r": -1.0, "pi_c": 1.0}, "id": "PIter", "gene_reaction_rule": "2544_AT1"}, {"subsystem": "Transport, Golgi 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"cmp_g": 1.0, "acngalgbside_hs_g": -1.0, "acn13acngalgbside_hs_g": 1.0}, "id": "ST6GALNAC21", "gene_reaction_rule": "10610_AT1"}, {"subsystem": "Sphingolipid Metabolism", "name": "ST6GALNAC22", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ST6GALNAC22"]}, "metabolites": {"cmp_g": 1.0, "h_g": 1.0, "acngalgbside_hs_g": -1.0, "acn23acngalgbside_hs_g": 1.0, "cmpacna_g": -1.0}, "id": "ST6GALNAC22", "gene_reaction_rule": "10610_AT1"}, {"subsystem": "Sphingolipid Metabolism", "name": "ST6GALNAC23", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ST6GALNAC23"]}, "metabolites": {"ga2_hs_g": -1.0, "h_g": 1.0, "gm2a_hs_g": 1.0, "cmp_g": 1.0, "cmpacna_g": -1.0}, "id": "ST6GALNAC23", "gene_reaction_rule": "10610_AT1"}, {"subsystem": "Sphingolipid Metabolism", "name": "ST6GALNAC24", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ST6GALNAC24"]}, "metabolites": {"cmpacna_g": -1.0, "h_g": 1.0, "gd1b2_hs_g": 1.0, "cmp_g": 1.0, "gm1a_hs_g": -1.0}, "id": "ST6GALNAC24", "gene_reaction_rule": "10610_AT1"}, {"subsystem": "Sphingolipid Metabolism", "name": "ST6GALNAC25", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ST6GALNAC25"]}, "metabolites": {"cmpacna_g": -1.0, "h_g": 1.0, "cmp_g": 1.0, "gt1alpha_hs_g": 1.0, "gd1alpha_hs_g": -1.0}, "id": "ST6GALNAC25", "gene_reaction_rule": "10610_AT1"}, {"subsystem": "Sphingolipid Metabolism", "name": "ST6GALNAC26", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ST6GALNAC26"]}, "metabolites": {"cmpacna_g": -1.0, "gq1balpha_hs_g": 1.0, "cmp_g": 1.0, "gt1alpha_hs_g": -1.0, "h_g": 1.0}, "id": "ST6GALNAC26", "gene_reaction_rule": "10610_AT1"}, {"subsystem": "Sphingolipid Metabolism", "name": "ST6GALNAC27", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ST6GALNAC27"]}, "metabolites": {"cmpacna_g": -1.0, "h_g": 1.0, "gq1c_hs_g": 1.0, "gt1c_hs_g": -1.0, "cmp_g": 1.0}, "id": "ST6GALNAC27", "gene_reaction_rule": "10610_AT1"}, {"subsystem": "Sphingolipid Metabolism", "name": "ST6GALNAC28", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ST6GALNAC28"]}, "metabolites": {"gp1c_hs_g": 1.0, "h_g": 1.0, "gq1c_hs_g": -1.0, "cmp_g": 1.0, "cmpacna_g": -1.0}, "id": "ST6GALNAC28", "gene_reaction_rule": "10610_AT1"}, {"subsystem": "Sphingolipid Metabolism", "name": "ST6GALNAC31", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ST6GALNAC31"]}, "metabolites": {"gm1b_hs_g": -1.0, "h_g": 1.0, "cmp_g": 1.0, "cmpacna_g": -1.0, "gd1alpha_hs_g": 1.0}, "id": "ST6GALNAC31", "gene_reaction_rule": "256435_AT1 or 30815_AT1 or 81849_AT1"}, {"subsystem": "Sphingolipid Metabolism", "name": "ST6GALNAC61", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ST6GALNAC61"]}, "metabolites": {"cmpacna_g": -1.0, "h_g": 1.0, "gd1a_hs_g": -1.0, "cmp_g": 1.0, "gt1alpha_hs_g": 1.0}, "id": "ST6GALNAC61", "gene_reaction_rule": "30815_AT1"}, {"subsystem": "Sphingolipid Metabolism", "name": "ST6GALNAC62", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ST6GALNAC62"]}, "metabolites": {"cmpacna_g": -1.0, "gq1balpha_hs_g": 1.0, "gt1b_hs_g": -1.0, "cmp_g": 1.0, "h_g": 1.0}, "id": "ST6GALNAC62", "gene_reaction_rule": "30815_AT1"}, {"subsystem": "Sphingolipid Metabolism", "name": "ST8SIA11", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ST8SIA11"]}, "metabolites": {"cmp_g": 1.0, "h_g": 1.0, "acngalgbside_hs_g": -1.0, "cmpacna_g": -1.0, "acnacngalgbside_hs_g": 1.0}, "id": "ST8SIA11", "gene_reaction_rule": "6489_AT1"}, {"subsystem": "Sphingolipid Metabolism", "name": "ST8SIA12", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ST8SIA12"]}, "metabolites": {"cmpacna_g": -1.0, "h_g": 1.0, "cmp_g": 1.0, "gd3_hs_g": 1.0, "gm3_hs_g": -1.0}, "id": "ST8SIA12", "gene_reaction_rule": "6489_AT1"}, {"subsystem": "Sphingolipid Metabolism", "name": "ST8SIA51g", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ST8SIA51g"]}, "metabolites": {"cmpacna_g": -1.0, "h_g": 1.0, "cmp_g": 1.0, "gd3_hs_g": -1.0, "gt3_hs_g": 1.0}, "id": "ST8SIA51g", "gene_reaction_rule": "29906_AT1"}, {"subsystem": "Sphingolipid Metabolism", "name": "ST8SIA52g", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ST8SIA52g"]}, "metabolites": {"cmpacna_g": -1.0, "h_g": 1.0, "cmp_g": 1.0, "gq1b_hs_g": 1.0, "gt1b_hs_g": -1.0}, "id": "ST8SIA52g", "gene_reaction_rule": "29906_AT1"}, {"subsystem": "Sphingolipid Metabolism", "name": "ST8SIA53g", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ST8SIA53g"]}, "metabolites": {"cmpacna_g": -1.0, "h_g": 1.0, "gt1a_hs_g": 1.0, "cmp_g": 1.0, "gd1a_hs_g": -1.0}, "id": "ST8SIA53g", "gene_reaction_rule": "29906_AT1"}, {"subsystem": "Sphingolipid Metabolism", "name": "ST8SIA54g", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ST8SIA54g"]}, "metabolites": {"cmpacna_g": -1.0, "h_g": 1.0, "cmp_g": 1.0, "gd1c_hs_g": 1.0, "gm1b_hs_g": -1.0}, "id": "ST8SIA54g", "gene_reaction_rule": "29906_AT1"}, {"subsystem": "Sphingolipid Metabolism", "name": "ST8SIA55g", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ST8SIA55g"]}, "metabolites": {"cmpacna_g": -1.0, "h_g": 1.0, "gq1c_hs_g": -1.0, "cmp_g": 1.0, "gp1calpha_hs_g": 1.0}, "id": "ST8SIA55g", "gene_reaction_rule": "29906_AT1"}, {"subsystem": "Blood Group Biosynthesis", "name": "ST8SIA56g", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ST8SIA56g"]}, "metabolites": {"cmpacna_g": -1.0, "h_g": 1.0, "acngal14acglcgalgluside_hs_g": -1.0, "cmp_g": 1.0, "acnacngal14acglcgalgluside_hs_g": 1.0}, "id": "ST8SIA56g", "gene_reaction_rule": "29906_AT1"}, {"subsystem": "Transport, Peroxisomal", "name": "STCOAtx", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["STCOAtx"]}, "metabolites": {"stcoa_c": -1.0, "stcoa_x": 1.0}, "id": "STCOAtx", "gene_reaction_rule": ""}, {"subsystem": "Carnitine shuttle", "name": "STRDNCCPT1", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["STRDNCCPT1"]}, "metabolites": {"crn_c": -1.0, "strdnccoa_c": -1.0, "strdnccrn_c": 1.0, "coa_c": 1.0}, "id": "STRDNCCPT1", "gene_reaction_rule": "1375_AT1 or 1375_AT3 or 1375_AT4 or 126129_AT1 or 1374_AT1 or 1375_AT2"}, {"subsystem": "Carnitine shuttle", "name": "STRDNCCPT2", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["STRDNCCPT2"]}, "metabolites": {"strdnccrn_m": -1.0, "coa_m": -1.0, "strdnccoa_m": 1.0, "crn_m": 1.0}, "id": "STRDNCCPT2", "gene_reaction_rule": "1376_AT1"}, {"subsystem": "Carnitine shuttle", "name": "STRDNCCRNt", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["STRDNCCRNt"]}, "metabolites": {"strdnccrn_c": -1.0, "strdnccrn_m": 1.0}, "id": "STRDNCCRNt", "gene_reaction_rule": "788_AT1"}, {"subsystem": "Transport, Extracellular", "name": "STRDNCt", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["STRDNCt"]}, "metabolites": {"strdnc_e": -1.0, "strdnc_c": 1.0}, "id": "STRDNCt", "gene_reaction_rule": ""}, {"subsystem": "Steroid Metabolism", "name": "STS1", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["STS1"]}, "metabolites": {"so4_c": 1.0, "h2o_c": -1.0, "dheas_c": -1.0, "h_c": 1.0, "dhea_c": 1.0}, "id": "STS1", "gene_reaction_rule": "412_AT1"}, {"subsystem": "Steroid Metabolism", "name": "STS1r", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["STS1r"]}, "metabolites": {"so4_r": 1.0, "h2o_r": -1.0, "h_r": 1.0, "dheas_r": -1.0, "dhea_r": 1.0}, "id": "STS1r", "gene_reaction_rule": "412_AT1"}, {"subsystem": "Steroid Metabolism", "name": "STS2", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["STS2"]}, "metabolites": {"so4_c": 1.0, "h2o_c": -1.0, "estrone_c": 1.0, "h_c": 1.0, "estrones_c": -1.0}, "id": "STS2", "gene_reaction_rule": "412_AT1"}, {"subsystem": "Steroid Metabolism", "name": "STS2r", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["STS2r"]}, "metabolites": {"estrone_r": 1.0, "estrones_r": -1.0, "h_r": 1.0, "so4_r": 1.0, "h2o_r": -1.0}, "id": "STS2r", "gene_reaction_rule": "412_AT1"}, {"subsystem": "Steroid Metabolism", "name": "STS3", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["STS3"]}, "metabolites": {"so4_c": 1.0, "h2o_c": -1.0, "chsterols_c": -1.0, "chsterol_c": 1.0, "h_c": 1.0}, "id": "STS3", "gene_reaction_rule": "412_AT1"}, {"subsystem": "Steroid Metabolism", "name": "STS3r", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["STS3r"]}, "metabolites": {"so4_r": 1.0, "chsterols_r": -1.0, "h2o_r": -1.0, "h_r": 1.0, "chsterol_r": 1.0}, "id": "STS3r", "gene_reaction_rule": "412_AT1"}, {"subsystem": "Steroid Metabolism", "name": "STS4", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["STS4"]}, "metabolites": {"h_c": 1.0, "so4_c": 1.0, "h2o_c": -1.0, "prgnlones_c": -1.0, "prgnlone_c": 1.0}, "id": "STS4", "gene_reaction_rule": "412_AT1"}, {"subsystem": "Steroid Metabolism", "name": "STS4r", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["STS4r"]}, "metabolites": {"so4_r": 1.0, "prgnlone_r": 1.0, "h_r": 1.0, "h2o_r": -1.0, "prgnlones_r": -1.0}, "id": "STS4r", "gene_reaction_rule": "412_AT1"}, {"subsystem": "Transport, Mitochondrial", "name": "Succinate transport mitochondrial", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["SUCCt2m"]}, "metabolites": {"succ_c": -1.0, "pi_c": 1.0, "succ_m": 1.0, "pi_m": -1.0}, "id": "SUCCtm", "gene_reaction_rule": "1468_AT1"}, {"subsystem": "Transport, Extracellular", "name": "SUCCt4 2", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["SUCCt4_2"]}, "metabolites": {"succ_c": 1.0, "na1_c": 2.0, "succ_e": -1.0, "na1_e": -2.0}, "id": "SUCCt4_2", "gene_reaction_rule": "9058_AT1"}, {"subsystem": "Transport, Extracellular", "name": "SUCCt4 3", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["SUCCt4_3"]}, "metabolites": {"succ_c": 1.0, "na1_c": 3.0, "succ_e": -1.0, "na1_e": -3.0}, "id": "SUCCt4_3", "gene_reaction_rule": "64849_AT1 or 64849_AT2"}, {"subsystem": "Transport, Peroxisomal", "name": "SUCCtp", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["SUCCtp"]}, "metabolites": {"succ_x": 1.0, "succ_c": -1.0}, "id": "SUCCtp", "gene_reaction_rule": ""}, {"subsystem": "Citric Acid Cycle", "name": "Succinate dehydrogenase", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["SUCD1m"]}, "metabolites": {"fad_m": -1.0, "fadh2_m": 1.0, "succ_m": -1.0, "fum_m": 1.0}, "id": "SUCD1m", "gene_reaction_rule": "6389_AT1 and 6392_AT1 and 6391_AT1 and 6390_AT1"}, {"subsystem": "Citric Acid Cycle", "name": "SUCOAS1m", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["SUCOAS1m"]}, "metabolites": {"succoa_m": 1.0, "gdp_m": 1.0, "pi_m": 1.0, "gtp_m": -1.0, "succ_m": -1.0, "coa_m": -1.0}, "id": "SUCOAS1m", "gene_reaction_rule": "8802_AT1 and 8801_AT1"}, {"subsystem": "Citric Acid Cycle", "name": "Succinate CoA ligase ADP forming ", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["SUCOASm"]}, "metabolites": {"succoa_m": 1.0, "atp_m": -1.0, "pi_m": 1.0, "adp_m": 1.0, "coa_m": -1.0, "succ_m": -1.0}, "id": "SUCOASm", "gene_reaction_rule": "8802_AT1 and 8803_AT1"}, {"subsystem": "Galactose metabolism", "name": "Sucrose hydrolyzing enxyme extracellular", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["SUCRe"]}, "metabolites": {"fru_e": 1.0, "h2o_e": -1.0, "sucr_e": -1.0, "glc__D_e": 1.0}, "id": "SUCRe", "gene_reaction_rule": "6476_AT1 or 8972_AT1"}, {"subsystem": "Cysteine Metabolism", "name": "SULFOX", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["SULFOX"]}, "metabolites": {"h2o_c": -1.0, "so3_c": -1.0, "ficytC_m": -2.0, "so4_c": 1.0, "h_c": 2.0, "focytC_m": 2.0}, "id": "SULFOX", "gene_reaction_rule": "6821_AT1"}, {"subsystem": "Limonene and pinene degradation", "name": "T2M26DCOAHLm", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["T2M26DCOAHLm"]}, "metabolites": {"3h26dm5coa_m": 1.0, "t2m26dcoa_m": -1.0, "h2o_m": -1.0}, "id": "T2M26DCOAHLm", "gene_reaction_rule": "549_AT1 or (3030_AT1 and 3032_AT1)"}, {"subsystem": "Limonene and pinene degradation", "name": "T2M26DCOAHLx", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["T2M26DCOAHLx"]}, "metabolites": {"h2o_x": -1.0, "3h26dm5coa_x": 1.0, "t2m26dcoa_x": -1.0}, "id": "T2M26DCOAHLx", "gene_reaction_rule": 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{"original_bigg_ids": ["2673.1"]}, "name": "GFPT1", "id": "2673_AT1"}, {"notes": {"original_bigg_ids": ["7264.1"]}, "name": "TSTA3", "id": "7264_AT1"}, {"notes": {"original_bigg_ids": ["8836.1"]}, "name": "GGH", "id": "8836_AT1"}, {"notes": {"original_bigg_ids": ["2655.1"]}, "name": "None", "id": "2655_AT1"}, {"notes": {"original_bigg_ids": ["2998.1"]}, "name": "GYS2", "id": "2998_AT1"}, {"notes": {"original_bigg_ids": ["8908.1"]}, "name": "GYG2", "id": "8908_AT1"}, {"notes": {"original_bigg_ids": ["2992.1"]}, "name": "GYG1", "id": "2992_AT1"}, {"notes": {"original_bigg_ids": ["2997.1"]}, "name": "GYS1", "id": "2997_AT1"}, {"notes": {"original_bigg_ids": ["2687.1"]}, "name": "GGT5", "id": "2687_AT1"}, {"notes": {"original_bigg_ids": ["6470.2"]}, "name": "SHMT1", "id": "6470_AT2"}, {"notes": {"original_bigg_ids": ["6470.1"]}, "name": "SHMT1", "id": "6470_AT1"}, {"notes": {"original_bigg_ids": ["6472.1"]}, "name": "SHMT2", "id": "6472_AT1"}, {"notes": {"original_bigg_ids": ["2717.1"]}, 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"id": "4669_AT1"}, {"notes": {"original_bigg_ids": ["64579.1"]}, "name": "NDST4", "id": "64579_AT1"}, {"notes": {"original_bigg_ids": ["3340.1"]}, "name": "NDST1", "id": "3340_AT1"}, {"notes": {"original_bigg_ids": ["8509.1"]}, "name": "NDST2", "id": "8509_AT1"}, {"notes": {"original_bigg_ids": ["9348.1"]}, "name": "NDST3", "id": "9348_AT1"}, {"notes": {"original_bigg_ids": ["1798.2"]}, "name": "DPAGT1", "id": "1798_AT2"}, {"notes": {"original_bigg_ids": ["1798.1"]}, "name": "DPAGT1", "id": "1798_AT1"}, {"notes": {"original_bigg_ids": ["2137.1"]}, "name": "EXTL3", "id": "2137_AT1"}, {"notes": {"original_bigg_ids": ["2135.1"]}, "name": "EXTL2", "id": "2135_AT1"}, {"notes": {"original_bigg_ids": ["2134.1"]}, "name": "EXTL1", "id": "2134_AT1"}, {"notes": {"original_bigg_ids": ["56606.1"]}, "name": "SLC2A9", "id": "56606_AT1"}, {"notes": {"original_bigg_ids": ["11182.1"]}, "name": "SLC2A6", "id": "11182_AT1"}, {"notes": {"original_bigg_ids": ["154091.1"]}, "name": "SLC2A12", "id": "154091_AT1"}, {"notes": {"original_bigg_ids": ["144195.1"]}, "name": "SLC2A14", "id": "144195_AT1"}, {"notes": {"original_bigg_ids": ["56606.2"]}, "name": "SLC2A9", "id": "56606_AT2"}, {"notes": {"original_bigg_ids": ["6524.1"]}, "name": "SLC5A2", "id": "6524_AT1"}, {"notes": {"original_bigg_ids": ["6526.1"]}, "name": "SLC5A3", "id": "6526_AT1"}, {"notes": {"original_bigg_ids": ["125206.1"]}, "name": "SLC5A10", "id": "125206_AT1"}, {"notes": {"original_bigg_ids": ["159963.1"]}, "name": "SLC5A12", "id": "159963_AT1"}, {"notes": {"original_bigg_ids": ["178.2"]}, "name": "AGL", "id": "178_AT2"}, {"notes": {"original_bigg_ids": ["178.1"]}, "name": "AGL", "id": "178_AT1"}, {"notes": {"original_bigg_ids": ["178.6"]}, "name": "AGL", "id": "178_AT6"}, {"notes": {"original_bigg_ids": ["178.5"]}, "name": "AGL", "id": "178_AT5"}, {"notes": {"original_bigg_ids": ["178.4"]}, "name": "AGL", "id": "178_AT4"}, {"notes": {"original_bigg_ids": ["178.3"]}, "name": "AGL", "id": "178_AT3"}, {"notes": {"original_bigg_ids": ["2752.1"]}, "name": "GLUL", "id": "2752_AT1"}, {"notes": {"original_bigg_ids": ["51557.1"]}, "name": "LGSN", "id": "51557_AT1"}, {"notes": {"original_bigg_ids": ["5834.1"]}, "name": "PYGB", "id": "5834_AT1"}, {"notes": {"original_bigg_ids": ["5836.1"]}, "name": "PYGL", "id": "5836_AT1"}, {"notes": {"original_bigg_ids": ["5837.1"]}, "name": "PYGM", "id": "5837_AT1"}, {"notes": {"original_bigg_ids": ["2729.1"]}, "name": "GCLC", "id": "2729_AT1"}, {"notes": {"original_bigg_ids": ["2730.1"]}, "name": "GCLM", "id": "2730_AT1"}, {"notes": {"original_bigg_ids": ["2746.1"]}, "name": "GLUD1", "id": "2746_AT1"}, {"notes": {"original_bigg_ids": ["2747.1"]}, "name": "GLUD2", "id": "2747_AT1"}, {"notes": {"original_bigg_ids": ["2744.1"]}, "name": "GLS", "id": "2744_AT1"}, {"notes": {"original_bigg_ids": ["27165.1"]}, "name": "GLS2", "id": "27165_AT1"}, {"notes": {"original_bigg_ids": ["27165.2"]}, "name": "GLS2", "id": "27165_AT2"}, {"notes": {"original_bigg_ids": 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["gchola_e"]}, "charge": 0, "formula": "C26H43NO6", "compartment": "e", "id": "gchola_e"}, {"name": "Gd1b2 hs c", "notes": {"original_bigg_ids": ["gd1b2_hs_e"]}, "charge": 0, "formula": "C66H111N4O38FULLRCO", "compartment": "e", "id": "gd1b2_hs_e"}, {"name": "Gd1c hs c", "notes": {"original_bigg_ids": ["gd1c_hs_e"]}, "charge": 0, "formula": "C66H111N4O38FULLRCO", "compartment": "e", "id": "gd1c_hs_e"}, {"name": "Gdchola c", "notes": {"original_bigg_ids": ["gdchola_e"]}, "charge": 0, "formula": "C26H43NO5", "compartment": "e", "id": "gdchola_e"}, {"name": "GDP", "notes": {"original_bigg_ids": ["gdp_e"]}, "charge": 0, "formula": "C10H12N5O11P2", "compartment": "e", "id": "gdp_e"}, {"name": "5 L Glutamyl L alanine C8H13N2O5", "notes": {"original_bigg_ids": ["gluala_e"]}, "charge": 0, "formula": "C8H13N2O5", "compartment": "e", "id": "gluala_e"}, {"name": "Glycine betaine", "notes": {"original_bigg_ids": ["glyb_e"]}, "charge": 0, "formula": "C5H11NO2", "compartment": "e", "id": "glyb_e"}, {"name": "Glycerol", "notes": {"original_bigg_ids": ["glyc_e"]}, "charge": 0, "formula": "C3H8O3", "compartment": "e", "id": "glyc_e"}, {"name": "Glyc S c", "notes": {"original_bigg_ids": ["glyc_DASH_S_e"]}, "charge": 0, "formula": "C3H5O4", "compartment": "e", "id": "glyc__S_e"}, {"name": "Glygn5 e", "notes": {"original_bigg_ids": ["glygn5_e"]}, "charge": 0, "formula": "C12H21O11X", "compartment": "e", "id": "glygn5_e"}, {"name": "GMP", "notes": {"original_bigg_ids": ["gmp_e"]}, "charge": 0, "formula": "C10H12N5O8P", "compartment": "e", "id": "gmp_e"}, {"name": "Gp1c hs c", "notes": {"original_bigg_ids": ["gp1c_hs_e"]}, "charge": 0, "formula": "C99H159N7O62FULLRCO", "compartment": "e", "id": "gp1c_hs_e"}, {"name": "Gp1calpha hs c", "notes": {"original_bigg_ids": ["gp1calpha_hs_e"]}, "charge": 0, "formula": "C99H159N7O62FULLRCO", "compartment": "e", "id": "gp1calpha_hs_e"}, {"name": "Gq1b hs c", "notes": {"original_bigg_ids": ["gq1b_hs_e"]}, "charge": 0, "formula": "C88H143N6O54FULLRCO", "compartment": "e", "id": "gq1b_hs_e"}, {"name": "Gq1balpha hs c", "notes": {"original_bigg_ids": ["gq1balpha_hs_e"]}, "charge": 0, "formula": "C88H143N6O54FULLRCO", "compartment": "e", "id": "gq1balpha_hs_e"}, {"name": "Guanosine", "notes": {"original_bigg_ids": ["gsn_e"]}, "charge": 0, "formula": "C10H13N5O5", "compartment": "e", "id": "gsn_e"}, {"name": "Gt1a hs c", "notes": {"original_bigg_ids": ["gt1a_hs_e"]}, "charge": 0, "formula": "C77H127N5O46FULLRCO", "compartment": "e", "id": "gt1a_hs_e"}, {"name": "Oxidized glutathione", "notes": {"original_bigg_ids": ["gthox_e"]}, "charge": 0, "formula": "C20H30N6O12S2", "compartment": "e", "id": "gthox_e"}, {"name": "Reduced glutathione", "notes": {"original_bigg_ids": ["gthrd_e"]}, "charge": 0, "formula": "C10H16N3O6S", "compartment": "e", "id": "gthrd_e"}, {"name": "GTP", "notes": {"original_bigg_ids": ["gtp_e"]}, "charge": 0, "formula": "C10H12N5O14P3", "compartment": "e", "id": "gtp_e"}, {"name": "Guanine", "notes": {"original_bigg_ids": ["gua_e"]}, "charge": 0, "formula": "C5H5N5O", "compartment": "e", "id": "gua_e"}, {"name": "Hydrogen peroxide", "notes": {"original_bigg_ids": ["h2o2_e"]}, "charge": 0, "formula": "H2O2", "compartment": "e", "id": "h2o2_e"}, {"name": "Ha e", "notes": {"original_bigg_ids": ["ha_e"]}, "charge": 0, "formula": "C28H40N2O22", "compartment": "e", "id": "ha_e"}, {"name": "Ha pre1 e", "notes": {"original_bigg_ids": ["ha_pre1_e"]}, "charge": 0, "formula": "C14H20NO11", "compartment": "e", "id": "ha_pre1_e"}, {"name": "Hcoumarin c", "notes": {"original_bigg_ids": ["hcoumarin_e"]}, "charge": 0, "formula": "C9H6O3", "compartment": "e", "id": "hcoumarin_e"}, {"name": "Hexadecanoate (n-C16:0)", "notes": {"original_bigg_ids": ["hdca_e"]}, "charge": 0, "formula": "C16H31O2", "compartment": "e", "id": "hdca_e"}, {"name": "Hexadecenoate (n-C16:1)", "notes": {"original_bigg_ids": ["hdcea_e"]}, "charge": 0, "formula": "C16H29O2", "compartment": "e", "id": "hdcea_e"}, {"name": "Hestratriol c", "notes": {"original_bigg_ids": ["hestratriol_e"]}, "charge": 0, "formula": "C18H24O3", "compartment": "e", "id": "hestratriol_e"}, {"name": "Hexacosanoate n C260 C26H51O2", "notes": {"original_bigg_ids": ["hexc_e"]}, "charge": 0, "formula": "C26H51O2", "compartment": "e", "id": "hexc_e"}, {"name": "L-Histidine", "notes": {"original_bigg_ids": ["his_DASH_L_e"]}, "charge": 0, "formula": "C6H9N3O2", "compartment": "e", "id": "his__L_e"}, {"name": "Hista c", "notes": {"original_bigg_ids": ["hista_e"]}, "charge": 0, "formula": "C5H10N3", "compartment": "e", "id": "hista_e"}, {"name": "L-Homoserine", "notes": {"original_bigg_ids": ["hom_DASH_L_e"]}, "charge": 0, "formula": "C4H9NO3", "compartment": "e", "id": "hom__L_e"}, {"name": "Hpdca c", "notes": {"original_bigg_ids": ["hpdca_e"]}, "charge": 0, "formula": "C17H33O2", "compartment": "e", "id": "hpdca_e"}, {"name": "Hspg e", "notes": {"original_bigg_ids": ["hspg_e"]}, "charge": 0, "formula": "C79H113N5O101S12X", "compartment": "e", "id": "hspg_e"}, {"name": "Htaxol c", "notes": {"original_bigg_ids": ["htaxol_e"]}, "charge": 0, "formula": "C47H31NO15", "compartment": "e", "id": "htaxol_e"}, {"name": "Hypoxanthine", "notes": {"original_bigg_ids": ["hxan_e"]}, "charge": 0, "formula": "C5H4N4O", "compartment": "e", "id": "hxan_e"}, {"name": "IDP", "notes": {"original_bigg_ids": ["idp_e"]}, "charge": 0, "formula": "C10H11N4O11P2", "compartment": "e", "id": "idp_e"}, {"name": "L-Isoleucine", "notes": {"original_bigg_ids": ["ile_DASH_L_e"]}, "charge": 0, "formula": "C6H13NO2", "compartment": "e", "id": "ile__L_e"}, {"name": "IMP", "notes": {"original_bigg_ids": ["imp_e"]}, "charge": 0, "formula": "C10H11N4O8P", "compartment": "e", "id": "imp_e"}, {"name": "Myo-Inositol", "notes": {"original_bigg_ids": ["inost_e"]}, "charge": 0, "formula": "C6H12O6", "compartment": "e", "id": "inost_e"}, {"name": "Ksi e", "notes": {"original_bigg_ids": ["ksi_e"]}, "charge": 0, "formula": "C247H393N17O213S12X", 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"formula": "XH", "compartment": "r", "id": "Ser_Gly_Ala_X_Gly_r"}, {"name": "D-Xylose", "notes": {"original_bigg_ids": ["xyl_DASH_D_c"]}, "charge": 0, "formula": "C5H10O5", "compartment": "c", "id": "xyl__D_c"}], "version": 1, "id": "RECON1"} \ No newline at end of file diff --git a/1-0-0/6/models/Saccharomyces cerevisiae/iMM904.json b/1-0-0/6/models/Saccharomyces cerevisiae/iMM904.json new file mode 100644 index 00000000..cef40981 --- /dev/null +++ b/1-0-0/6/models/Saccharomyces cerevisiae/iMM904.json @@ -0,0 +1 @@ +{"reactions": [{"subsystem": "S_Starch_and_Sucrose_Metabolism", "name": "Endo 1 3 beta glucan glucohydrase", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["13BGH"]}, "metabolites": {"13BDglcn_c": -1.0, "glc__D_c": 1.0, "h2o_c": -1.0}, "id": "13BGH", "gene_reaction_rule": "YGR282C"}, {"subsystem": "S_Starch_and_Sucrose_Metabolism", "name": "Exo 1 3 beta glucan glucohydrase", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": 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"name": "Guanylate kinase GMPdATP ", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["GK2"]}, "metabolites": {"datp_c": -1.0, "gmp_c": -1.0, "gdp_c": 1.0, "dadp_c": 1.0}, "id": "GK2", "gene_reaction_rule": "YDR454C"}, {"subsystem": "S_Alternate_Carbon_Metabolism", "name": "Glucan 1 4 alpha glucosidase", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLCGSD"]}, "metabolites": {"glc__D_c": 1.0, "h2o_c": -1.0, "glycogen_c": -1.0}, "id": "GLCGSD", "gene_reaction_rule": "YPR184W"}, {"subsystem": "S_Alternate_Carbon_Metabolism", "name": "Glucan 1 4 alpha glucosidase vacuole", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLCGSDv"]}, "metabolites": {"glycogen_v": -1.0, "glc__D_v": 1.0, "h2o_v": -1.0}, "id": "GLCGSDv", "gene_reaction_rule": "YIL099W"}, {"subsystem": "S_Transport__Vacuolar", "name": "Glycogen vacuolar transport via autophagy", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": 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1.0, "glc__D_e": -1.0}, "id": "GLCt1", "gene_reaction_rule": "YHR092C or YLR081W or YOL156W or YDR536W or YHR094C or YEL069C or YDL245C or YJR158W or YFL011W or YNR072W or YMR011W or YDR345C or YHR096C or YDR343C or YDR342C or YJL214W or YJL219W"}, {"subsystem": "S_Transport__Vacuolar", "name": "Glucose transport vacuolar", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["GLCtv"]}, "metabolites": {"glc__D_c": -1.0, "glc__D_v": 1.0}, "id": "GLCtv", "gene_reaction_rule": ""}, {"subsystem": "S_Glutamine_Metabolism", "name": "Glutamine synthetase", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLNS"]}, "metabolites": {"atp_c": -1.0, "glu__L_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "nh4_c": -1.0, "gln__L_c": 1.0}, "id": "GLNS", "gene_reaction_rule": "YPR035W"}, {"subsystem": "S_tRNA_charging", "name": "Glutaminyl-tRNA synthetase", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLNTRS"]}, "metabolites": {"glntrna_c": 1.0, "atp_c": -1.0, "trnagln_c": -1.0, "ppi_c": 1.0, "amp_c": 1.0, "gln__L_c": -1.0}, "id": "GLNTRS", "gene_reaction_rule": "YOR168W"}, {"subsystem": "S_Transport__Nuclear", "name": "Glutamine nuclear transport via proton symport", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["GLNt2n"]}, "metabolites": {"h_n": 1.0, "gln__L_n": 1.0, "h_c": -1.0, "gln__L_c": -1.0}, "id": "GLNt2n", "gene_reaction_rule": ""}, {"subsystem": "S_Transport__Extracellular", "name": "L glutamine reversible transport via proton symport", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["GLNt2r"]}, "metabolites": {"gln__L_e": -1.0, "h_e": -1.0, "h_c": 1.0, "gln__L_c": 1.0}, "id": "GLNt2r", "gene_reaction_rule": "YKR039W or YCL025C or YDR508C or YPL265W"}, {"subsystem": "S_Transport__Vacuolar", "name": "L glutamine transport in via proton antiport vacuolar ", "upper_bound": 999999.0, "lower_bound": 0.0, 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"leu__L_c"}, {"name": "L-Leucyl-tRNA(Leu)", "notes": {"original_bigg_ids": ["leutrna_c"]}, "charge": 1, "formula": "C6H12NOR", "compartment": "c", "id": "leutrna_c"}, {"name": "(R)-S-Lactoylglutathione", "notes": {"original_bigg_ids": ["lgt_S_c"]}, "charge": -1, "formula": "C13H20N3O8S", "compartment": "c", "id": "lgt__S_c"}, {"name": "L-Lysine", "notes": {"original_bigg_ids": ["lys_L_c"]}, "charge": 1, "formula": "C6H15N2O2", "compartment": "c", "id": "lys__L_c"}, {"name": "L-Lysine-tRNA (Lys)", "notes": {"original_bigg_ids": ["lystrna_c"]}, "charge": 2, "formula": "C6H14N2OR", "compartment": "c", "id": "lystrna_c"}, {"name": "L-Malate", "notes": {"original_bigg_ids": ["mal_L_c"]}, "charge": -2, "formula": "C4H4O5", "compartment": "c", "id": "mal__L_c"}, {"name": "Malonyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["malACP_c"]}, "charge": -2, "formula": "C14H22N2O10PRS", "compartment": "c", "id": "malACP_c"}, {"name": "Malonyl-CoA", "notes": {"original_bigg_ids": 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"5,10-Methenyltetrahydrofolate", "notes": {"original_bigg_ids": ["methf_c"]}, "charge": -1, "formula": "C20H20N7O6", "compartment": "c", "id": "methf_c"}, {"name": "L-Methionyl-tRNA (Met)", "notes": {"original_bigg_ids": ["mettrna_c"]}, "charge": 1, "formula": "C5H10NOSR", "compartment": "c", "id": "mettrna_c"}, {"name": "1D-myo-Inositol 1-phosphate", "notes": {"original_bigg_ids": ["mi1p_D_c"]}, "charge": -2, "formula": "C6H11O9P", "compartment": "c", "id": "mi1p__D_c"}, {"name": "5,10-Methylenetetrahydrofolate", "notes": {"original_bigg_ids": ["mlthf_c"]}, "charge": -2, "formula": "C20H21N7O6", "compartment": "c", "id": "mlthf_c"}, {"name": "S-Methyl-L-methionine", "notes": {"original_bigg_ids": ["mmet_c"]}, "charge": 1, "formula": "C6H14NO2S", "compartment": "c", "id": "mmet_c"}, {"name": "Methylglyoxal", "notes": {"original_bigg_ids": ["mthgxl_c"]}, "charge": 0, "formula": "C3H4O2", "compartment": "c", "id": "mthgxl_c"}, {"name": "Myristoyl-ACP (n-C14:0ACP)", "notes": 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0, "formula": "C5H10O", "compartment": "c", "id": "2mbald_c"}, {"name": "2 methyl 1 butanol C5H12O", "notes": {"original_bigg_ids": ["2mbtoh_c"]}, "charge": 0, "formula": "C5H12O", "compartment": "c", "id": "2mbtoh_c"}, {"name": "2 methylpropanal C4H8O", "notes": {"original_bigg_ids": ["2mppal_c"]}, "charge": 0, "formula": "C4H8O", "compartment": "c", "id": "2mppal_c"}, {"name": "2 Oxoadipate C6H6O5", "notes": {"original_bigg_ids": ["2oxoadp_c"]}, "charge": -2, "formula": "C6H6O5", "compartment": "c", "id": "2oxoadp_c"}, {"name": "2 phenylethanol C8H10O", "notes": {"original_bigg_ids": ["2phetoh_c"]}, "charge": 0, "formula": "C8H10O", "compartment": "c", "id": "2phetoh_c"}, {"name": "3 5 Cyclic CMP C9H11N3O7P", "notes": {"original_bigg_ids": ["35ccmp_c"]}, "charge": -1, "formula": "C9H11N3O7P", "compartment": "c", "id": "35ccmp_c"}, {"name": "3 5 Cyclic dAMP C10H11N5O5P", "notes": {"original_bigg_ids": ["35cdamp_c"]}, "charge": -1, "formula": "C10H11N5O5P", "compartment": "c", "id": "35cdamp_c"}, {"name": "3 5 Cyclic IMP C10H10N4O7P", "notes": {"original_bigg_ids": ["35cimp_c"]}, "charge": -1, "formula": "C10H10N4O7P", "compartment": "c", "id": "35cimp_c"}, {"name": "3 Hexaprenyl 4 5 dihydroxybenzoate C37H53O4", "notes": {"original_bigg_ids": ["3dh5hpb_c"]}, "charge": -1, "formula": "C37H53O4", "compartment": "c", "id": "3dh5hpb_c"}, {"name": "3 Dehydrosphinganine C18H38NO2", "notes": {"original_bigg_ids": ["3dsphgn_c"]}, "charge": 1, "formula": "C18H38NO2", "compartment": "c", "id": "3dsphgn_c"}, {"name": "3 Hydroxyanthranilate C7H7NO3", "notes": {"original_bigg_ids": ["3hanthrn_c"]}, "charge": 0, "formula": "C7H7NO3", "compartment": "c", "id": "3hanthrn_c"}, {"name": "3 isopropylmalate methyl ester C8H13O5", "notes": {"original_bigg_ids": ["3ipmmest_c"]}, "charge": -1, "formula": "C8H13O5", "compartment": "c", "id": "3ipmmest_c"}, {"name": "3 Methylbutanal C5H10O", "notes": {"original_bigg_ids": ["3mbald_c"]}, "charge": 0, "formula": "C5H10O", "compartment": "c", "id": "3mbald_c"}, {"name": "3 Hexaprenyl 4 hydroxybenzoate C37H53O3", "notes": {"original_bigg_ids": ["3ophb_5_c"]}, "charge": -1, "formula": "C37H53O3", "compartment": "c", "id": "3ophb_5_c"}, {"name": "4 4 dimethylcholesta 8 14 24 trienol C29H46O", "notes": {"original_bigg_ids": ["44mctr_c"]}, "charge": 0, "formula": "C29H46O", "compartment": "c", "id": "44mctr_c"}, {"name": "4 4 dimethylzymosterol C29H48O", "notes": {"original_bigg_ids": ["44mzym_c"]}, "charge": 0, "formula": "C29H48O", "compartment": "c", "id": "44mzym_c"}, {"name": "4 Acetamidobutanoate C6H10NO3", "notes": {"original_bigg_ids": ["4aabutn_c"]}, "charge": -1, "formula": "C6H10NO3", "compartment": "c", "id": "4aabutn_c"}, {"name": "4 Fumarylacetoacetate C8H6O6", "notes": {"original_bigg_ids": ["4fumacac_c"]}, "charge": -2, "formula": "C8H6O6", "compartment": "c", "id": "4fumacac_c"}, {"name": "4 Guanidinobutanamide C5H13N4O", "notes": {"original_bigg_ids": ["4gudbd_c"]}, "charge": 1, "formula": "C5H13N4O", "compartment": "c", "id": "4gudbd_c"}, {"name": "4 Guanidinobutanoate C5H11N3O2", "notes": {"original_bigg_ids": ["4gudbutn_c"]}, "charge": 0, "formula": "C5H11N3O2", "compartment": "c", "id": "4gudbutn_c"}, {"name": "4 Hydroxy 2 oxoglutarate C5H4O6", "notes": {"original_bigg_ids": ["4h2oglt_c"]}, "charge": -2, "formula": "C5H4O6", "compartment": "c", "id": "4h2oglt_c"}, {"name": "Trans 4 Hydroxy L proline C5H9NO3", "notes": {"original_bigg_ids": ["4hpro_LT_c"]}, "charge": 0, "formula": "C5H9NO3", "compartment": "c", "id": "4hpro_LT_c"}, {"name": "4 Maleylacetoacetate C8H6O6", "notes": {"original_bigg_ids": ["4mlacac_c"]}, "charge": -2, "formula": "C8H6O6", "compartment": "c", "id": "4mlacac_c"}, {"name": "4 methylzymosterol C28H46O", "notes": {"original_bigg_ids": ["4mzym_c"]}, "charge": 0, "formula": "C28H46O", "compartment": "c", "id": "4mzym_c"}, {"name": "4 Methylzymosterol intermediate 1 C29H46O3", "notes": {"original_bigg_ids": ["4mzym_int1_c"]}, "charge": 0, "formula": "C29H46O3", "compartment": "c", "id": "4mzym_int1_c"}, {"name": "4 Methylzymosterol intermediate 2 C28H44O", "notes": {"original_bigg_ids": ["4mzym_int2_c"]}, "charge": 0, "formula": "C28H44O", "compartment": "c", "id": "4mzym_int2_c"}, {"name": " R 5 Diphosphomevalonate C6H10O10P2", "notes": {"original_bigg_ids": ["5dpmev_c"]}, "charge": -4, "formula": "C6H10O10P2", "compartment": "c", "id": "5dpmev_c"}, {"name": " R 5 Phosphomevalonate C6H10O7P", "notes": {"original_bigg_ids": ["5pmev_c"]}, "charge": -3, "formula": "C6H10O7P", "compartment": "c", "id": "5pmev_c"}, {"name": "D Gal alpha 1 6D Glucose C12H22O11", "notes": {"original_bigg_ids": ["6dg_c"]}, "charge": 0, "formula": "C12H22O11", "compartment": "c", "id": "6dg_c"}, {"name": "D Arabinono 1 4 lactone C5H8O5", "notes": {"original_bigg_ids": ["Dara14lac_c"]}, "charge": 0, "formula": "C5H8O5", "compartment": "c", "id": "Dara14lac_c"}, {"name": "L 2 Aminoadipate 6 semialdehyde C6H11NO3", "notes": {"original_bigg_ids": ["L2aadp6sa_c"]}, "charge": 0, "formula": "C6H11NO3", "compartment": "c", "id": "L2aadp6sa_c"}, {"name": "L 2 Aminoadipate C6H10NO4", "notes": {"original_bigg_ids": ["L2aadp_c"]}, "charge": -1, "formula": "C6H10NO4", "compartment": "c", "id": "L2aadp_c"}, {"name": "L Cystine C6H12N2O4S2", "notes": {"original_bigg_ids": ["Lcystin_c"]}, "charge": 0, "formula": "C6H12N2O4S2", "compartment": "c", "id": "Lcystin_c"}, {"name": "L Formylkynurenine C11H12N2O4", "notes": {"original_bigg_ids": ["Lfmkynr_c"]}, "charge": 0, "formula": "C11H12N2O4", "compartment": "c", "id": "Lfmkynr_c"}, {"name": "L Kynurenine C10H12N2O3", "notes": {"original_bigg_ids": ["Lkynr_c"]}, "charge": 0, "formula": "C10H12N2O3", "compartment": "c", "id": "Lkynr_c"}, {"name": "N1 Acetylspermine C12H31N4O", "notes": {"original_bigg_ids": ["N1sprm_c"]}, "charge": 3, "formula": "C12H31N4O", "compartment": "c", "id": "N1sprm_c"}, {"name": "N pai Methyl L histidine C7H11N3O2", "notes": {"original_bigg_ids": ["NPmehis_c"]}, "charge": 0, "formula": "C7H11N3O2", "compartment": "c", "id": "NPmehis_c"}, {"name": "N N bisformyl dityrosine C20H22N2O8", "notes": {"original_bigg_ids": ["Nbfortyr_c"]}, "charge": -2, "formula": "C20H22N2O8", "compartment": "c", "id": "Nbfortyr_c"}, {"name": "N Formyl L tyrosine C10H10NO4", "notes": {"original_bigg_ids": ["Nfortyr_c"]}, "charge": -1, "formula": "C10H10NO4", "compartment": "c", "id": "Nfortyr_c"}, {"name": " S Squalene 2 3 epoxide C30H50O", "notes": {"original_bigg_ids": ["Ssq23epx_c"]}, "charge": 0, "formula": "C30H50O", "compartment": "c", "id": "Ssq23epx_c"}, {"name": "L Arabinitol C5H12O5", "notes": {"original_bigg_ids": ["abt_c"]}, "charge": 0, "formula": "C5H12O5", "compartment": "c", "id": "abt_c"}, {"name": "Acetic ester C4H8O2", "notes": {"original_bigg_ids": ["aces_c"]}, "charge": 0, "formula": "C4H8O2", "compartment": "c", "id": "aces_c"}, {"name": "O Acetyl L homoserine C6H11NO4", "notes": {"original_bigg_ids": ["achms_c"]}, "charge": 0, "formula": "C6H11NO4", "compartment": "c", "id": "achms_c"}, {"name": "E 3 carboxyl 2 pentenedioate 5 methyl ester C7H6O6", "notes": {"original_bigg_ids": ["acon5m_c"]}, "charge": -2, "formula": "C7H6O6", "compartment": "c", "id": "acon5m_c"}, {"name": "O Acetylcarnitine C9H17NO4", "notes": {"original_bigg_ids": ["acrn_c"]}, "charge": 0, "formula": "C9H17NO4", "compartment": "c", "id": "acrn_c"}, {"name": " R Acetoin C4H8O2", "notes": {"original_bigg_ids": ["actn_R_c"]}, "charge": 0, "formula": "C4H8O2", "compartment": "c", "id": "actn__R_c"}, {"name": "Gamma Amino gamma cyanobutanoate C5H8N2O2", "notes": {"original_bigg_ids": ["acybut_c"]}, "charge": 0, "formula": "C5H8N2O2", "compartment": "c", "id": "acybut_c"}, {"name": "Allophanate C2H3N2O3", "notes": {"original_bigg_ids": ["allphn_c"]}, "charge": -1, "formula": "C2H3N2O3", "compartment": "c", "id": "allphn_c"}, {"name": "Adenosine 2 phosphate C10H14N5O7P", "notes": {"original_bigg_ids": ["amp2p_c"]}, "charge": 0, "formula": "C10H14N5O7P", "compartment": "c", "id": "amp2p_c"}, {"name": "P1 5 adenosyl P4 5 guanosyl tetraphosphate C20H24N10O20P4", "notes": {"original_bigg_ids": ["ap4g_c"]}, "charge": -4, "formula": "C20H24N10O20P4", "compartment": "c", "id": "ap4g_c"}, {"name": "Nalpha Acetylpeptide C6H7N2O4R2", "notes": {"original_bigg_ids": ["apep_c"]}, "charge": -1, "formula": "C6H7N2O4R2", "compartment": "c", "id": "apep_c"}, {"name": "3 Aminopropanal C3H8NO", "notes": {"original_bigg_ids": ["aproa_c"]}, "charge": 1, "formula": "C3H8NO", "compartment": "c", "id": "aproa_c"}, {"name": "Alpha Aminopropiononitrile C3H7N2", "notes": {"original_bigg_ids": ["aprop_c"]}, "charge": 1, "formula": "C3H7N2", "compartment": "c", "id": "aprop_c"}, {"name": "N Acetylputrescine C6H15N2O", "notes": {"original_bigg_ids": ["aprut_c"]}, "charge": 1, "formula": "C6H15N2O", "compartment": "c", "id": "aprut_c"}, {"name": "D Arabinose C5H10O5", "notes": {"original_bigg_ids": ["arab_D_c"]}, "charge": 0, "formula": "C5H10O5", "compartment": "c", "id": "arab__D_c"}, {"name": "Biotinyl 5 AMP C20H27N7O9PS", "notes": {"original_bigg_ids": ["btamp_c"]}, "charge": -1, "formula": "C20H27N7O9PS", "compartment": "c", "id": "btamp_c"}, {"name": " R R 2 3 Butanediol C4H10O2", "notes": {"original_bigg_ids": ["btd_RR_c"]}, "charge": 0, "formula": "C4H10O2", "compartment": "c", "id": "btd_RR_c"}, {"name": "2 3 Carboxy 3 aminopropyl L histidine C10H16N4O4", "notes": {"original_bigg_ids": ["caphis_c"]}, "charge": 0, "formula": "C10H16N4O4", "compartment": "c", "id": "caphis_c"}, {"name": "CDPcholine C14H25N4O11P2", "notes": {"original_bigg_ids": ["cdpchol_c"]}, "charge": -1, "formula": "C14H25N4O11P2", "compartment": "c", "id": "cdpchol_c"}, {"name": "CDPdiacylglycerol yeast specific C4440H7744N300O1500P200", "notes": {"original_bigg_ids": ["cdpdag_SC_c"]}, "charge": -200, "formula": "C4440H7744N300O1500P200", "compartment": "c", "id": "cdpdag_SC_c"}, {"name": "CDPethanolamine C11H19N4O11P2", "notes": {"original_bigg_ids": ["cdpea_c"]}, "charge": -1, "formula": "C11H19N4O11P2", "compartment": "c", "id": "cdpea_c"}, {"name": "Ceramide 1 Sphinganinen C240 C42H85NO3", "notes": {"original_bigg_ids": ["cer1_24_c"]}, "charge": 0, "formula": "C42H85NO3", "compartment": "c", "id": "cer1_24_c"}, {"name": "Ceramide 1 Sphinganinen C260 C44H89NO3", "notes": {"original_bigg_ids": ["cer1_26_c"]}, "charge": 0, "formula": "C44H89NO3", "compartment": "c", "id": "cer1_26_c"}, {"name": "Ceramide 2 Phytosphingosinen C240 C42H85NO4", "notes": {"original_bigg_ids": ["cer2_24_c", "cer2__24_c"]}, "charge": 0, "formula": "C42H85NO4", "compartment": "c", "id": "cer2_24_c"}, {"name": "Ceramide 2 Phytosphingosinen C260 C44H89NO4", "notes": {"original_bigg_ids": ["cer2_26_c", "cer2__26_c"]}, "charge": 0, "formula": "C44H89NO4", "compartment": "c", "id": "cer2_26_c"}, {"name": "Ceramide 3 Phytosphingosinen C240OH C42H85NO5", "notes": {"original_bigg_ids": ["cer3_24_c"]}, "charge": 0, "formula": "C42H85NO5", "compartment": "c", "id": "cer3_24_c"}, {"name": "Ceramide 3 Phytosphingosinen C260OH C44H89NO5", "notes": {"original_bigg_ids": ["cer3_26_c"]}, "charge": 0, "formula": "C44H89NO5", "compartment": "c", "id": "cer3_26_c"}, {"name": "Methanethiol CH4S", "notes": {"original_bigg_ids": ["ch4s_c"]}, "charge": 0, "formula": "CH4S", "compartment": "c", "id": "ch4s_c"}, {"name": "Chitin monomer C8H13NO5", "notes": {"original_bigg_ids": ["chitin_c"]}, "charge": 0, "formula": "C8H13NO5", "compartment": "c", "id": "chitin_c"}, {"name": "Chitosan C6H11NO4", "notes": {"original_bigg_ids": ["chitos_c"]}, "charge": 0, "formula": "C6H11NO4", "compartment": "c", "id": "chitos_c"}, {"name": "Choline phosphate C5H13NO4P", "notes": {"original_bigg_ids": ["cholp_c"]}, "charge": -1, "formula": "C5H13NO4P", "compartment": "c", "id": "cholp_c"}, {"name": "2 3 Carboxy 3 methylammonio propyl L histidine C11H18N4O4", "notes": {"original_bigg_ids": ["cmaphis_c"]}, "charge": 0, "formula": "C11H18N4O4", "compartment": "c", "id": "cmaphis_c"}, {"name": "2 Amino 3 carboxymuconate semialdehyde C7H6NO5", "notes": {"original_bigg_ids": ["cmusa_c"]}, "charge": -1, "formula": "C7H6NO5", "compartment": "c", "id": "cmusa_c"}, {"name": "Diacylglycerol pyrophosphate yeast specific C3540H6544O1100P200", "notes": {"original_bigg_ids": ["dagpy_SC_c"]}, "charge": -300, "formula": "C3540H6544O1100P200", "compartment": "c", "id": "dagpy_SC_c"}, {"name": "Dolichol C15H28O", "notes": {"original_bigg_ids": ["dolichol_c"]}, "charge": 0, "formula": "C15H28O", "compartment": "c", "id": "dolichol_c"}, {"name": "Dolichol phosphate C15H27O4P", "notes": {"original_bigg_ids": ["dolp_c"]}, "charge": -2, "formula": "C15H27O4P", "compartment": "c", "id": "dolp_c"}, {"name": "Deoxyribose C5H10O4", "notes": {"original_bigg_ids": ["drib_c"]}, "charge": 0, "formula": "C5H10O4", "compartment": "c", "id": "drib_c"}, {"name": "L erythro 4 Hydroxyglutamate C5H8NO5", "notes": {"original_bigg_ids": ["e4hglu_c"]}, "charge": -1, "formula": "C5H8NO5", "compartment": "c", "id": "e4hglu_c"}, {"name": "Episterol C28H46O", "notes": {"original_bigg_ids": ["epist_c"]}, "charge": 0, "formula": "C28H46O", "compartment": "c", "id": "epist_c"}, {"name": "Episterol ester yeast specific C1695H2995O101", "notes": {"original_bigg_ids": ["epistest_SC_c"]}, "charge": 0, "formula": "C1695H2995O101", "compartment": "c", "id": "epistest_SC_c"}, {"name": "Epimelibiose C12H22O11", "notes": {"original_bigg_ids": ["epm_c"]}, "charge": 0, "formula": "C12H22O11", "compartment": "c", "id": "epm_c"}, {"name": "Ergosterol 3 beta D glucoside C34H54O6", "notes": {"original_bigg_ids": ["ergst3glc_c"]}, "charge": 0, "formula": "C34H54O6", "compartment": "c", "id": "ergst3glc_c"}, {"name": "Ergosterol C28H44O", "notes": {"original_bigg_ids": ["ergst_c"]}, "charge": 0, "formula": "C28H44O", "compartment": "c", "id": "ergst_c"}, {"name": "Ergosterol ester yeast specific C1695H2993O101", "notes": {"original_bigg_ids": ["ergstest_SC_c"]}, "charge": 0, "formula": "C1695H2993O101", "compartment": "c", "id": "ergstest_SC_c"}, {"name": "Ergosta 5 7 22 24 28 tetraen 3beta ol C28H42O", "notes": {"original_bigg_ids": ["ergtetrol_c"]}, "charge": 0, "formula": "C28H42O", "compartment": "c", "id": "ergtetrol_c"}, {"name": "Ergosta 5 7 24 28 trienol C28H44O", "notes": {"original_bigg_ids": ["ergtrol_c"]}, "charge": 0, "formula": "C28H44O", "compartment": "c", "id": "ergtrol_c"}, {"name": "D erythro Ascorbate C5H6O5", "notes": {"original_bigg_ids": ["ertascb_D_c"]}, "charge": 0, "formula": "C5H6O5", "compartment": "c", "id": "ertascb__D_c"}, {"name": "Ethanolamine phosphate C2H7NO4P", "notes": {"original_bigg_ids": ["ethamp_c"]}, "charge": -1, "formula": "C2H7NO4P", "compartment": "c", "id": "ethamp_c"}, {"name": "D Fructose 2 6 bisphosphate C6H10O12P2", "notes": {"original_bigg_ids": ["f26bp_c"]}, "charge": -4, "formula": "C6H10O12P2", "compartment": "c", "id": "f26bp_c"}, {"name": "Fecosterol C28H46O", "notes": {"original_bigg_ids": ["fecost_c"]}, "charge": 0, "formula": "C28H46O", "compartment": "c", "id": "fecost_c"}, {"name": "Fecosterol ester yeast specific C1695H2995O101", "notes": {"original_bigg_ids": ["fecostest_SC_c"]}, "charge": 0, "formula": "C1695H2995O101", "compartment": "c", "id": "fecostest_SC_c"}, {"name": "Beta D glucose 6 phosphate C6H11O9P", "notes": {"original_bigg_ids": ["g6p_B_c"]}, "charge": -2, "formula": "C6H11O9P", "compartment": "c", "id": "g6p_B_c"}, {"name": "Geranylgeranyl diphosphate C20H33O7P2", "notes": {"original_bigg_ids": ["ggdp_c"]}, "charge": -3, "formula": "C20H33O7P2", "compartment": "c", "id": "ggdp_c"}, {"name": "Galactosylglycerol C9H18O8", "notes": {"original_bigg_ids": ["ggl_c"]}, "charge": 0, "formula": "C9H18O8", "compartment": "c", "id": "ggl_c"}, {"name": "Glycylpeptide C4H7N2O3R", "notes": {"original_bigg_ids": ["glp_c"]}, "charge": 0, "formula": "C4H7N2O3R", "compartment": "c", "id": "glp_c"}, {"name": "5 L Glutamyl L alanine C8H13N2O5", "notes": {"original_bigg_ids": ["gluala_c"]}, "charge": -1, "formula": 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"indpyr_c"}, {"name": "Inositol phosphorylceramide ceramide 1 24C yeast specific C4800H9500N100O1100P100", "notes": {"original_bigg_ids": ["ipc124_SC_c"]}, "charge": -100, "formula": "C4800H9500N100O1100P100", "compartment": "c", "id": "ipc124_SC_c"}, {"name": "Inositol phosphorylceramide ceramide 1 26C yeast specific C5000H9900N100O1100P100", "notes": {"original_bigg_ids": ["ipc126_SC_c"]}, "charge": -100, "formula": "C5000H9900N100O1100P100", "compartment": "c", "id": "ipc126_SC_c"}, {"name": "Inositol phosphorylceramide ceramide 2 24C yeast specific C4800H9500N100O1200P100", "notes": {"original_bigg_ids": ["ipc224_SC_c"]}, "charge": -100, "formula": "C4800H9500N100O1200P100", "compartment": "c", "id": "ipc224_SC_c"}, {"name": "Inositol phosphorylceramide ceramide 2 26C yeast specific C5000H9900N100O1200P100", "notes": {"original_bigg_ids": ["ipc226_SC_c"]}, "charge": -100, "formula": "C5000H9900N100O1200P100", "compartment": "c", "id": "ipc226_SC_c"}, {"name": "Inositol 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{"original_bigg_ids": ["asp_L_v"]}, "charge": -1, "formula": "C4H6NO4", "compartment": "v", "id": "asp__L_v"}, {"name": "ATP", "notes": {"original_bigg_ids": ["atp_v"]}, "charge": -4, "formula": "C10H12N5O13P3", "compartment": "v", "id": "atp_v"}, {"name": "CO2", "notes": {"original_bigg_ids": ["co2_v"]}, "charge": 0, "formula": "CO2", "compartment": "v", "id": "co2_v"}, {"name": "D-Glucose", "notes": {"original_bigg_ids": ["glc_D_v"]}, "charge": 0, "formula": "C6H12O6", "compartment": "v", "id": "glc__D_v"}, {"name": "L-Glutamine", "notes": {"original_bigg_ids": ["gln_L_v"]}, "charge": 0, "formula": "C5H10N2O3", "compartment": "v", "id": "gln__L_v"}, {"name": "L-Glutamate", "notes": {"original_bigg_ids": ["glu_L_v"]}, "charge": -1, "formula": "C5H8NO4", "compartment": "v", "id": "glu__L_v"}, {"name": "Glycogen", "notes": {"original_bigg_ids": ["glycogen_v"]}, "charge": 0, "formula": "C6H10O5", "compartment": "v", "id": "glycogen_v"}, {"name": "Reduced glutathione", "notes": {"original_bigg_ids": ["gthrd_v"]}, "charge": -1, "formula": "C10H16N3O6S", "compartment": "v", "id": "gthrd_v"}, {"name": "H+", "notes": {"original_bigg_ids": ["h_v"]}, "charge": 1, "formula": "H", "compartment": "v", "id": "h_v"}, {"name": "H2O", "notes": {"original_bigg_ids": ["h2o_v"]}, "charge": 0, "formula": "H2O", "compartment": "v", "id": "h2o_v"}, {"name": "L-Histidine", "notes": {"original_bigg_ids": ["his_L_v"]}, "charge": 0, "formula": "C6H9N3O2", "compartment": "v", "id": "his__L_v"}, {"name": "L-Isoleucine", "notes": {"original_bigg_ids": ["ile_L_v"]}, "charge": 0, "formula": "C6H13NO2", "compartment": "v", "id": "ile__L_v"}, {"name": "L-Leucine", "notes": {"original_bigg_ids": ["leu_L_v"]}, "charge": 0, "formula": "C6H13NO2", "compartment": "v", "id": "leu__L_v"}, {"name": "L-Lysine", "notes": {"original_bigg_ids": ["lys_L_v"]}, "charge": 1, "formula": "C6H15N2O2", "compartment": "v", "id": "lys__L_v"}, {"name": "Phosphate", "notes": {"original_bigg_ids": ["pi_v"]}, "charge": -2, "formula": "HO4P", "compartment": "v", "id": "pi_v"}, {"name": "Trehalose", "notes": {"original_bigg_ids": ["tre_v"]}, "charge": 0, "formula": "C12H22O11", "compartment": "v", "id": "tre_v"}, {"name": "L-Tyrosine", "notes": {"original_bigg_ids": ["tyr_L_v"]}, "charge": 0, "formula": "C9H11NO3", "compartment": "v", "id": "tyr__L_v"}, {"name": "L Cystine C6H12N2O4S2", "notes": {"original_bigg_ids": ["Lcystin_v"]}, "charge": 0, "formula": "C6H12N2O4S2", "compartment": "v", "id": "Lcystin_v"}, {"name": "Phosphatidylethanolamine yeast specific C3740H7244N100O800P100", "notes": {"original_bigg_ids": ["pe_SC_v"]}, "charge": 0, "formula": "C3740H7244N100O800P100", "compartment": "v", "id": "pe_SC_v"}, {"name": "Phosphatidylserine yeast specific C3840H7144N100O1000P100", "notes": {"original_bigg_ids": ["ps_SC_v"]}, "charge": -100, "formula": "C3840H7144N100O1000P100", "compartment": "v", "id": "ps_SC_v"}, {"name": "Taurocholic acid C26H45NO7S", "notes": {"original_bigg_ids": ["tchola_v"]}, "charge": 0, "formula": "C26H45NO7S", "compartment": "v", "id": "tchola_v"}, {"name": "Acetyl-CoA", "notes": {"original_bigg_ids": ["accoa_n"]}, "charge": -4, "formula": "C23H34N7O17P3S", "compartment": "n", "id": "accoa_n"}, {"name": "ADP", "notes": {"original_bigg_ids": ["adp_n"]}, "charge": -3, "formula": "C10H12N5O10P2", "compartment": "n", "id": "adp_n"}, {"name": "2-Oxoglutarate", "notes": {"original_bigg_ids": ["akg_n"]}, "charge": -2, "formula": "C5H4O5", "compartment": "n", "id": "akg_n"}, {"name": "AMP", "notes": {"original_bigg_ids": ["amp_n"]}, "charge": -2, "formula": "C10H12N5O7P", "compartment": "n", "id": "amp_n"}, {"name": "L-Aspartate", "notes": {"original_bigg_ids": ["asp_L_n"]}, "charge": -1, "formula": "C4H6NO4", "compartment": "n", "id": "asp__L_n"}, {"name": "ATP", "notes": {"original_bigg_ids": ["atp_n"]}, "charge": -4, "formula": "C10H12N5O13P3", "compartment": "n", "id": "atp_n"}, {"name": "N-Carbamoyl-L-aspartate", "notes": {"original_bigg_ids": ["cbasp_n"]}, "charge": -2, "formula": "C5H6N2O5", "compartment": "n", "id": "cbasp_n"}, {"name": "Carbamoyl phosphate", "notes": {"original_bigg_ids": ["cbp_n"]}, "charge": -2, "formula": "CH2NO5P", "compartment": "n", "id": "cbp_n"}, {"name": "CDP", "notes": {"original_bigg_ids": ["cdp_n"]}, "charge": -3, "formula": "C9H12N3O11P2", "compartment": "n", "id": "cdp_n"}, {"name": "CO2", "notes": {"original_bigg_ids": ["co2_n"]}, "charge": 0, "formula": "CO2", "compartment": "n", "id": "co2_n"}, {"name": "Coenzyme A", "notes": {"original_bigg_ids": ["coa_n"]}, "charge": -4, "formula": "C21H32N7O16P3S", "compartment": "n", "id": "coa_n"}, {"name": "DADP", "notes": {"original_bigg_ids": ["dadp_n"]}, "charge": -3, "formula": "C10H12N5O9P2", "compartment": "n", "id": "dadp_n"}, {"name": "DCDP", "notes": {"original_bigg_ids": ["dcdp_n"]}, "charge": -3, "formula": "C9H12N3O10P2", "compartment": "n", "id": "dcdp_n"}, {"name": "DGDP", "notes": {"original_bigg_ids": ["dgdp_n"]}, "charge": -3, "formula": "C10H12N5O10P2", "compartment": "n", "id": "dgdp_n"}, {"name": "Deamino-NAD+", "notes": {"original_bigg_ids": ["dnad_n"]}, "charge": -2, "formula": "C21H24N6O15P2", "compartment": "n", "id": "dnad_n"}, {"name": "DUDP", "notes": {"original_bigg_ids": ["dudp_n"]}, "charge": -3, "formula": "C9H11N2O11P2", "compartment": "n", "id": "dudp_n"}, {"name": "DUMP", "notes": {"original_bigg_ids": ["dump_n"]}, "charge": -2, "formula": "C9H11N2O8P", "compartment": "n", "id": "dump_n"}, {"name": "GDP", "notes": {"original_bigg_ids": ["gdp_n"]}, "charge": -3, "formula": "C10H12N5O11P2", "compartment": "n", "id": "gdp_n"}, {"name": "L-Glutamine", "notes": {"original_bigg_ids": ["gln_L_n"]}, "charge": 0, "formula": "C5H10N2O3", "compartment": "n", "id": "gln__L_n"}, {"name": "L-Glutamate", "notes": {"original_bigg_ids": ["glu_L_n"]}, "charge": -1, "formula": "C5H8NO4", "compartment": "n", "id": "glu__L_n"}, {"name": "H+", "notes": {"original_bigg_ids": ["h_n"]}, "charge": 1, "formula": "H", "compartment": "n", "id": "h_n"}, {"name": "H2O", "notes": {"original_bigg_ids": ["h2o_n"]}, "charge": 0, "formula": "H2O", "compartment": "n", "id": "h2o_n"}, {"name": "Hydrogen peroxide", "notes": {"original_bigg_ids": ["h2o2_n"]}, "charge": 0, "formula": "H2O2", "compartment": "n", "id": "h2o2_n"}, {"name": "Bicarbonate", "notes": {"original_bigg_ids": ["hco3_n"]}, "charge": -1, "formula": "CHO3", "compartment": "n", "id": "hco3_n"}, {"name": "Nicotinamide adenine dinucleotide", "notes": {"original_bigg_ids": ["nad_n"]}, "charge": -1, "formula": "C21H26N7O14P2", "compartment": "n", "id": "nad_n"}, {"name": "Ammonium", "notes": {"original_bigg_ids": ["nh4_n"]}, "charge": 1, "formula": "H4N", "compartment": "n", "id": "nh4_n"}, {"name": "Phosphate", "notes": {"original_bigg_ids": ["pi_n"]}, "charge": -2, "formula": "HO4P", "compartment": "n", "id": "pi_n"}, {"name": "Diphosphate", "notes": {"original_bigg_ids": ["ppi_n"]}, "charge": -3, "formula": "HO7P2", "compartment": "n", "id": "ppi_n"}, {"name": "Oxidized thioredoxin", "notes": {"original_bigg_ids": ["trdox_n"]}, "charge": 0, "formula": "X", "compartment": "n", "id": "trdox_n"}, {"name": "Reduced thioredoxin", "notes": {"original_bigg_ids": ["trdrd_n"]}, "charge": 0, "formula": "XH2", "compartment": "n", "id": "trdrd_n"}, {"name": "UDP", "notes": {"original_bigg_ids": ["udp_n"]}, "charge": -3, "formula": "C9H11N2O12P2", "compartment": "n", "id": "udp_n"}, {"name": "UMP", "notes": {"original_bigg_ids": ["ump_n"]}, "charge": -2, "formula": "C9H11N2O9P", "compartment": "n", "id": "ump_n"}, {"name": "Myo-Inositol hexakisphosphate", "notes": {"original_bigg_ids": ["minohp_n"]}, "charge": -12, "formula": "C6H6O24P6", "compartment": "n", "id": "minohp_n"}, {"name": "2 Hydroxybutane 1 2 4 tricarboxylate C7H7O7", "notes": {"original_bigg_ids": ["hcit_n"]}, "charge": -3, "formula": "C7H7O7", "compartment": "n", "id": "hcit_n"}, {"name": "1D myo Inositol 1 3 4 5 6 pentakisphosphate C6H7O21P5", "notes": {"original_bigg_ids": ["mi13456p_n"]}, "charge": -10, "formula": "C6H7O21P5", "compartment": "n", "id": "mi13456p_n"}, {"name": "1D myo Inositol 1 3 4 5 tetrakisphosphate C6H8O18P4", "notes": {"original_bigg_ids": ["mi1345p_n"]}, "charge": -8, "formula": "C6H8O18P4", "compartment": "n", "id": "mi1345p_n"}, {"name": "1D myo Inositol 1 4 5 6 tetrakisphosphate C6H8O18P4", "notes": {"original_bigg_ids": ["mi1456p_n"]}, "charge": -8, "formula": "C6H8O18P4", "compartment": "n", "id": "mi1456p_n"}, {"name": "1D myo Inositol 1 4 5 trisphosphate C6H9O15P3", "notes": {"original_bigg_ids": ["mi145p_n"]}, "charge": -6, "formula": "C6H9O15P3", "compartment": "n", "id": "mi145p_n"}, {"name": "Phosphatidyl 1D myo inositol yeast specific C4140H7644O1300P100", "notes": {"original_bigg_ids": ["ptd1ino_SC_n"]}, "charge": -100, "formula": "C4140H7644O1300P100", "compartment": "n", "id": "ptd1ino_SC_n"}, {"name": "Phosphatidyl 1D myo 4 inositol yeast specific C4140H7544O1600P200", "notes": {"original_bigg_ids": ["ptd4ino_SC_n"]}, "charge": -300, "formula": "C4140H7544O1600P200", "compartment": "n", "id": "ptd4ino_SC_n"}, {"name": "ADP", "notes": {"original_bigg_ids": ["adp_g"]}, "charge": -3, "formula": "C10H12N5O10P2", "compartment": "g", "id": "adp_g"}, {"name": "ATP", "notes": {"original_bigg_ids": ["atp_g"]}, "charge": -4, "formula": "C10H12N5O13P3", "compartment": "g", "id": "atp_g"}, {"name": "CO2", "notes": {"original_bigg_ids": ["co2_g"]}, "charge": 0, "formula": "CO2", "compartment": "g", "id": "co2_g"}, {"name": "GDP", "notes": {"original_bigg_ids": ["gdp_g"]}, "charge": -3, "formula": "C10H12N5O11P2", "compartment": "g", "id": "gdp_g"}, {"name": "GDP-D-mannose", "notes": {"original_bigg_ids": ["gdpmann_g"]}, "charge": -2, "formula": "C16H23N5O16P2", "compartment": "g", "id": "gdpmann_g"}, {"name": "GMP", "notes": {"original_bigg_ids": ["gmp_g"]}, "charge": -2, "formula": "C10H12N5O8P", "compartment": "g", "id": "gmp_g"}, {"name": "H+", "notes": {"original_bigg_ids": ["h_g"]}, "charge": 1, "formula": "H", "compartment": "g", "id": "h_g"}, {"name": "H2O", "notes": {"original_bigg_ids": ["h2o_g"]}, "charge": 0, "formula": "H2O", "compartment": "g", "id": "h2o_g"}, {"name": "Phosphate", "notes": {"original_bigg_ids": ["pi_g"]}, "charge": -2, "formula": "HO4P", "compartment": "g", "id": "pi_g"}, {"name": "UDPgalactose", "notes": {"original_bigg_ids": ["udpgal_g"]}, "charge": -2, "formula": "C15H22N2O17P2", "compartment": "g", "id": "udpgal_g"}, {"name": "Alpha D mannosyl beta D mannosyl diacylchitobiosyldiphosphodolichol C43H74N2O27P2", "notes": {"original_bigg_ids": ["m1macchitppdol_g"]}, "charge": -2, "formula": "C43H74N2O27P2", "compartment": "g", "id": "m1macchitppdol_g"}, {"name": " alpha D mannosyl 2 beta D mannosyl diacetylchitobiosyldiphosphodolichol C49H84N2O32P2", "notes": {"original_bigg_ids": ["m2macchitppdol_g"]}, "charge": -2, "formula": "C49H84N2O32P2", "compartment": "g", "id": "m2macchitppdol_g"}, {"name": " alpha D mannosyl 3 beta D mannosyl diacetylchitodiphosphodolichol C55H94N2O37P2", "notes": {"original_bigg_ids": ["m3macchitppdol_g"]}, "charge": -2, "formula": "C55H94N2O37P2", "compartment": "g", "id": "m3macchitppdol_g"}, {"name": " alpha D Mannosyl 4 beta D mannosyl diacetylchitobiosyldiphosphodolichol C61H104N2O42P2", "notes": {"original_bigg_ids": ["m4macchitppdol_g"]}, "charge": -2, "formula": "C61H104N2O42P2", "compartment": "g", "id": "m4macchitppdol_g"}, {"name": "Beta D Mannosyldiacetylchitobiosyldiphosphodolichol C37H64N2O22P2", "notes": {"original_bigg_ids": ["macchitppdol_g"]}, "charge": -2, "formula": "C37H64N2O22P2", "compartment": "g", "id": "macchitppdol_g"}, {"name": "Phosphatidylethanolamine yeast specific C3740H7244N100O800P100", "notes": {"original_bigg_ids": ["pe_SC_g"]}, "charge": 0, "formula": "C3740H7244N100O800P100", "compartment": "g", "id": "pe_SC_g"}, {"name": "Phosphatidylserine yeast specific C3840H7144N100O1000P100", "notes": {"original_bigg_ids": ["ps_SC_g"]}, "charge": -100, "formula": "C3840H7144N100O1000P100", "compartment": "g", "id": "ps_SC_g"}], "version": 1, "id": "iMM904"} \ No newline at end of file From b657ddb64a815e63a2e8b637ec73814186f673ba Mon Sep 17 00:00:00 2001 From: Zak King Date: Wed, 17 Apr 2019 11:49:12 -0700 Subject: [PATCH 2/3] updated models for BiGG 1.5 --- .../models/Escherichia coli/e_coli_core.json | 3886 +- 1-0-0/6/models/Escherichia coli/iJO1366.json | 83920 +++++++++- 1-0-0/6/models/Homo sapiens/RECON1.json | 122074 ++++++++++++++- .../Saccharomyces cerevisiae/iMM904.json | 53542 ++++++- 4 files changed, 263418 insertions(+), 4 deletions(-) diff --git a/1-0-0/6/models/Escherichia coli/e_coli_core.json b/1-0-0/6/models/Escherichia coli/e_coli_core.json index 1cbb00f1..ae491f6d 100644 --- a/1-0-0/6/models/Escherichia coli/e_coli_core.json +++ b/1-0-0/6/models/Escherichia coli/e_coli_core.json @@ -1 +1,3885 @@ -{"reactions": [{"subsystem": "Pyruvate Metabolism", "name": "Acetaldehyde dehydrogenase (acetylating)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACALD"]}, "metabolites": {"accoa_c": 1.0, "acald_c": -1.0, "coa_c": -1.0, "h_c": 1.0, "nad_c": -1.0, "nadh_c": 1.0}, "id": "ACALD", "gene_reaction_rule": "b0351 or b1241"}, {"subsystem": "Transport, Extracellular", "name": "Acetaldehyde reversible transport", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACALDt"]}, "metabolites": {"acald_c": 1.0, "acald_e": -1.0}, "id": "ACALDt", "gene_reaction_rule": "s0001"}, {"subsystem": "Pyruvate Metabolism", "name": "Acetate kinase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACKr"]}, "metabolites": {"ac_c": -1.0, "actp_c": 1.0, "atp_c": -1.0, "adp_c": 1.0}, "id": "ACKr", "gene_reaction_rule": "b3115 or b2296 or b1849"}, {"subsystem": "Citric Acid Cycle", "name": "Aconitase (half-reaction A, Citrate hydro-lyase)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACONTa"]}, "metabolites": {"h2o_c": 1.0, "acon_C_c": 1.0, "cit_c": -1.0}, "id": "ACONTa", "gene_reaction_rule": "b0118 or b1276"}, {"subsystem": "Citric Acid Cycle", "name": "Aconitase (half-reaction B, Isocitrate hydro-lyase)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACONTb"]}, "metabolites": {"h2o_c": -1.0, "icit_c": 1.0, "acon_C_c": -1.0}, "id": "ACONTb", "gene_reaction_rule": "b0118 or b1276"}, {"subsystem": "Transport, Extracellular", "name": "Acetate reversible transport via proton symport", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACt2r"]}, "metabolites": {"ac_c": 1.0, "h_e": -1.0, "ac_e": -1.0, "h_c": 1.0}, "id": "ACt2r", "gene_reaction_rule": ""}, {"subsystem": "Oxidative Phosphorylation", "name": "Adenylate kinase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ADK1"]}, "metabolites": {"amp_c": -1.0, "atp_c": -1.0, "adp_c": 2.0}, "id": "ADK1", "gene_reaction_rule": "b0474"}, {"subsystem": "Citric Acid Cycle", "name": "2-Oxogluterate dehydrogenase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AKGDH"]}, "metabolites": {"akg_c": -1.0, "nadh_c": 1.0, "succoa_c": 1.0, "coa_c": -1.0, "nad_c": -1.0, "co2_c": 1.0}, "id": "AKGDH", "gene_reaction_rule": "b0116 and b0726 and b0727"}, {"subsystem": "Transport, Extracellular", "name": "2 oxoglutarate reversible transport via symport", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["AKGt2r"]}, "metabolites": {"akg_c": 1.0, "h_e": -1.0, "h_c": 1.0, "akg_e": -1.0}, "id": "AKGt2r", "gene_reaction_rule": "b2587"}, {"subsystem": "Pyruvate Metabolism", "name": "Alcohol dehydrogenase (ethanol)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ALCD2x"]}, "metabolites": {"acald_c": 1.0, "nadh_c": 1.0, "nad_c": -1.0, "etoh_c": -1.0, "h_c": 1.0}, "id": "ALCD2x", "gene_reaction_rule": "b0356 or 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"name": "L-Tryptophan exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_trp_DASH_L_LPAREN_e_RPAREN_"]}, "metabolites": {"trp__L_e": -1.0}, "id": "EX_trp__L_e", "gene_reaction_rule": ""}, {"subsystem": null, "name": "Thiosulfate exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_tsul_LPAREN_e_RPAREN_"]}, "metabolites": {"tsul_e": -1.0}, "id": "EX_tsul_e", "gene_reaction_rule": ""}, {"subsystem": null, "name": "Tetradecanoate (n-C14:0) exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_ttdca_LPAREN_e_RPAREN_"]}, "metabolites": {"ttdca_e": -1.0}, "id": "EX_ttdca_e", "gene_reaction_rule": ""}, {"subsystem": null, "name": "Tetradecenoate (n-C14:1) exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_ttdcea_LPAREN_e_RPAREN_"]}, "metabolites": {"ttdcea_e": -1.0}, "id": "EX_ttdcea_e", "gene_reaction_rule": ""}, {"subsystem": null, "name": "Tetracycline exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_ttrcyc_LPAREN_e_RPAREN_"]}, "metabolites": {"ttrcyc_e": -1.0}, "id": "EX_ttrcyc_e", "gene_reaction_rule": ""}, {"subsystem": null, "name": "Tungstate exchange", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["EX_tungs_LPAREN_e_RPAREN_"]}, "metabolites": {"tungs_e": -1.0}, "id": "EX_tungs_e", "gene_reaction_rule": ""}, {"subsystem": null, "name": "Tyramine exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_tym_LPAREN_e_RPAREN_"]}, "metabolites": {"tym_e": -1.0}, "id": "EX_tym_e", "gene_reaction_rule": ""}, {"subsystem": null, "name": "L-Tyrosine exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_tyr_DASH_L_LPAREN_e_RPAREN_"]}, "metabolites": {"tyr__L_e": -1.0}, "id": "EX_tyr__L_e", "gene_reaction_rule": ""}, {"subsystem": null, "name": "Phosphotyrosine exchange", 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"Glycerophospholipid Metabolism", "name": "2-acyl-glycerophospho-ethanolamine acyltransferase (n-C14:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["2AGPEAT141"]}, "metabolites": {"atp_c": -1.0, "ppi_c": 1.0, "2agpe141_c": -1.0, "amp_c": 1.0, "pe141_c": 1.0, "ttdcea_c": -1.0}, "id": "2AGPEAT141", "gene_reaction_rule": "b2836"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "2-acyl-glycerophospho-ethanolamine acyltransferase (n-C16:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["2AGPEAT160"]}, "metabolites": {"atp_c": -1.0, "2agpe160_c": -1.0, "ppi_c": 1.0, "amp_c": 1.0, "hdca_c": -1.0, "pe160_c": 1.0}, "id": "2AGPEAT160", "gene_reaction_rule": "b2836"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "2-acyl-glycerophospho-ethanolamine acyltransferase (n-C16:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["2AGPEAT161"]}, "metabolites": {"atp_c": -1.0, "ppi_c": 1.0, 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"AACPS6", "gene_reaction_rule": "b2836 and b1094"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "Acyl-[acyl-carrier-protein] synthetase (n-C12:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AACPS7"]}, "metabolites": {"atp_c": -1.0, "ddca_c": -1.0, "ppi_c": 1.0, "ACP_c": -1.0, "amp_c": 1.0, "ddcaACP_c": 1.0}, "id": "AACPS7", "gene_reaction_rule": "b2836 and b1094"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "Acyl-[acyl-carrier-protein] synthetase (n-C10:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AACPS8"]}, "metabolites": {"dcaACP_c": 1.0, "atp_c": -1.0, "ppi_c": 1.0, "ACP_c": -1.0, "amp_c": 1.0, "dca_c": -1.0}, "id": "AACPS8", "gene_reaction_rule": "b2836 and b1094"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "Acyl-[acyl-carrier-protein] synthetase (n-C8:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AACPS9"]}, "metabolites": {"atp_c": -1.0, "ppi_c": 1.0, 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and Proline Metabolism", "name": "Aminobutyraldehyde dehydrogenase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ABUTD"]}, "metabolites": {"h2o_c": -1.0, "4abutn_c": -1.0, "4abut_c": 1.0, "h_c": 2.0, "nad_c": -1.0, "nadh_c": 1.0}, "id": "ABUTD", "gene_reaction_rule": "b1444"}, {"subsystem": "Transport, Inner Membrane", "name": "4-aminobutyrate transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ABUTt2pp"]}, "metabolites": {"4abut_p": -1.0, "h_c": 1.0, "h_p": -1.0, "4abut_c": 1.0}, "id": "ABUTt2pp", "gene_reaction_rule": "b2663"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "4-aminobutyrate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ABUTtex"]}, "metabolites": {"4abut_e": -1.0, "4abut_p": 1.0}, "id": "ABUTtex", "gene_reaction_rule": "b0241 or b0929 or b1377 or b2215"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Acetyl-CoA:acetoacetyl-CoA transferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ACACCT"]}, "metabolites": {"acac_c": -1.0, "aacoa_c": 1.0, "ac_c": 1.0, "accoa_c": -1.0}, "id": "ACACCT", "gene_reaction_rule": "b2221 and b2222"}, {"subsystem": "Membrane Lipid Metabolism", "name": "Acetyl-CoA C-acetyltransferase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACACT1r"]}, "metabolites": {"aacoa_c": 1.0, "coa_c": 1.0, "accoa_c": -2.0}, "id": "ACACT1r", "gene_reaction_rule": "b2224 or b2342 or b3845"}, {"subsystem": "Membrane Lipid Metabolism", "name": "Acetyl-CoA C-acyltransferase (butanoyl-CoA) (r)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACACT2r"]}, "metabolites": {"btcoa_c": -1.0, "coa_c": 1.0, "accoa_c": -1.0, "3ohcoa_c": 1.0}, "id": "ACACT2r", "gene_reaction_rule": "b2342 or b3845"}, {"subsystem": "Membrane Lipid Metabolism", "name": "Acetyl-CoA C-acyltransferase (hexanoyl-CoA) (r)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACACT3r"]}, "metabolites": {"3oocoa_c": 1.0, "coa_c": 1.0, "accoa_c": -1.0, "hxcoa_c": -1.0}, "id": "ACACT3r", "gene_reaction_rule": "b2342 or b3845"}, {"subsystem": "Membrane Lipid Metabolism", "name": "Acetyl-CoA C-acyltransferase (octanoyl-CoA) (r)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACACT4r"]}, "metabolites": {"coa_c": 1.0, "3odcoa_c": 1.0, "occoa_c": -1.0, "accoa_c": -1.0}, "id": "ACACT4r", "gene_reaction_rule": "b2342 or b3845"}, {"subsystem": "Membrane Lipid Metabolism", "name": "Acetyl-CoA C-acyltransferase (decanoyl-CoA) (r)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACACT5r"]}, "metabolites": {"3oddcoa_c": 1.0, "coa_c": 1.0, "dcacoa_c": -1.0, "accoa_c": -1.0}, "id": "ACACT5r", "gene_reaction_rule": "b2342 or b3845"}, {"subsystem": "Membrane Lipid Metabolism", "name": "Acetyl-CoA C-acyltransferase (dodecanoyl-CoA) (r)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACACT6r"]}, "metabolites": {"ddcacoa_c": -1.0, "3otdcoa_c": 1.0, "coa_c": 1.0, "accoa_c": -1.0}, "id": "ACACT6r", "gene_reaction_rule": "b2342 or b3845"}, {"subsystem": "Membrane Lipid Metabolism", "name": "Acetyl-CoA C-acyltransferase (tetradecanoyl-CoA) (r)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACACT7r"]}, "metabolites": {"coa_c": 1.0, "accoa_c": -1.0, "tdcoa_c": -1.0, "3ohdcoa_c": 1.0}, "id": "ACACT7r", "gene_reaction_rule": "b2342 or b3845"}, {"subsystem": "Membrane Lipid Metabolism", "name": "Acetyl-CoA acyltransferase (hexadecanoyl-CoA), (r)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACACT8r"]}, "metabolites": {"pmtcoa_c": 1.0, "3oodcoa_c": -1.0, "coa_c": -1.0, "accoa_c": 1.0}, "id": "ACACT8r", "gene_reaction_rule": "b2342 or b3845"}, {"subsystem": "Transport, 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"metabolites": {"adocbl_p": 1.0, "h_c": 1.0, "h_p": -1.0, "adocbl_e": -1.0}, "id": "ADOCBLtonex", "gene_reaction_rule": "b3966 and (b1252 and b3005 and b3006)"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "ADPribose diphosphatase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ADPRDP"]}, "metabolites": {"amp_c": 1.0, "r5p_c": 1.0, "h2o_c": -1.0, "adprib_c": -1.0, "h_c": 2.0}, "id": "ADPRDP", "gene_reaction_rule": "b3397 or b3034"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Adenine phosphoribosyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ADPT"]}, "metabolites": {"ppi_c": 1.0, "ade_c": -1.0, "amp_c": 1.0, "prpp_c": -1.0}, "id": "ADPT", "gene_reaction_rule": "b0469"}, {"subsystem": "Cysteine Metabolism", "name": "Adenylyl-sulfate kinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ADSK"]}, "metabolites": {"aps_c": -1.0, "paps_c": 1.0, "h_c": 1.0, "adp_c": 1.0, 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"Alternate Carbon Metabolism", "name": "N-acetylglucosamine-6-phosphate deacetylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AGDC"]}, "metabolites": {"ac_c": 1.0, "acgam6p_c": -1.0, "h2o_c": -1.0, "gam6p_c": 1.0}, "id": "AGDC", "gene_reaction_rule": "b0677"}, {"subsystem": "Murein Recycling", "name": "N-Acetyl-D-glucosamine(anhydrous)N-Acetylmuramyl-tripeptide amidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AGM3PA"]}, "metabolites": {"LalaDgluMdap_c": 1.0, "h2o_c": -1.0, "anhgm3p_c": -1.0, "anhgm_c": 1.0}, "id": "AGM3PA", "gene_reaction_rule": "b0110"}, {"subsystem": "Murein Recycling", "name": "N-Acetyl-D-glucosamine(anhydrous)N-Acetylmuramyl-tripeptide amidase (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AGM3PApp"]}, "metabolites": {"h2o_p": -1.0, "LalaDgluMdap_p": 1.0, "anhgm3p_p": -1.0, "anhgm_p": 1.0}, "id": "AGM3PApp", "gene_reaction_rule": "b2435 or b2817 or 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"gene_reaction_rule": "b0381 or b0092"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "D-alanyl-D-alanine (DalaDala) transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ALAALAtex"]}, "metabolites": {"alaala_e": -1.0, "alaala_p": 1.0}, "id": "ALAALAtex", "gene_reaction_rule": "b0241 or b0929 or b1377 or b2215"}, {"subsystem": "Murein Recycling", "name": "L-alanyl-gamma-glutamate epimerase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ALAGLUE"]}, "metabolites": {"LalaLglu_c": 1.0, "LalaDglu_c": -1.0}, "id": "ALAGLUE", "gene_reaction_rule": "b1325"}, {"subsystem": "Alanine and Aspartate Metabolism", "name": "Alanine racemase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ALAR"]}, "metabolites": {"ala__D_c": 1.0, "ala__L_c": -1.0}, "id": "ALAR", "gene_reaction_rule": "b1190 or b4053"}, {"subsystem": "Cofactor and Prosthetic 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{"subsystem": "Transport, Inner Membrane", "name": "L-alanine transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ALAt2pp", "ALAt2rpp"]}, "metabolites": {"ala__L_c": 1.0, "h_c": 1.0, "h_p": -1.0, "ala__L_p": -1.0}, "id": "ALAt2pp_copy2", "gene_reaction_rule": ""}, {"subsystem": "Transport, Inner Membrane", "name": "L-alanine transport in via sodium symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALAt4pp"]}, "metabolites": {"na1_p": -1.0, "na1_c": 1.0, "ala__L_c": 1.0, "ala__L_p": -1.0}, "id": "ALAt4pp", "gene_reaction_rule": "b0007"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "L-alanine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ALAtex"]}, "metabolites": {"ala__L_e": -1.0, "ala__L_p": 1.0}, "id": "ALAtex", "gene_reaction_rule": "b0241 or b0929 or b1377 or 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"Acyl-phosphate:glycerol-3-phosphate acyltransferase (C14:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["APG3PAT141"]}, "metabolites": {"ttdceap_c": -1.0, "glyc3p_c": -1.0, "pi_c": 1.0, "h_c": 1.0, "1tdec7eg3p_c": 1.0}, "id": "APG3PAT141", "gene_reaction_rule": "b3059"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Acyl-phosphate:glycerol-3-phosphate acyltransferase (C16:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["APG3PAT160"]}, "metabolites": {"glyc3p_c": -1.0, "pi_c": 1.0, "1hdecg3p_c": 1.0, "hdcap_c": -1.0, "h_c": 1.0}, "id": "APG3PAT160", "gene_reaction_rule": "b3059"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Acyl-phosphate:glycerol-3-phosphate acyltransferase (C16:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["APG3PAT161"]}, "metabolites": {"hdceap_c": -1.0, "glyc3p_c": -1.0, "pi_c": 1.0, "h_c": 1.0, "1hdec9eg3p_c": 1.0}, "id": "APG3PAT161", 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["CITtex"]}, "metabolites": {"cit_e": -1.0, "cit_p": 1.0}, "id": "CITtex", "gene_reaction_rule": "b0241 or b0929 or b1377 or b2215"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "Cold lipid A transport via ABC system (periplasm to extracellular)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CLIPAabctex"]}, "metabolites": {"lipa_cold_e": 1.0, "atp_c": -1.0, "h2o_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "lipa_cold_p": -1.0, "pi_c": 1.0}, "id": "CLIPAabctex", "gene_reaction_rule": "b3200 and b3201 and b3199 and b4261 and b4262"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Cardiolipin hydrolase (periplasm, n-C12:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CLPNH120pp"]}, "metabolites": {"h2o_p": -1.0, "pg120_p": 1.0, "h_p": 1.0, "pa120_p": 1.0, "clpn120_p": -1.0}, "id": "CLPNH120pp", "gene_reaction_rule": ""}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Cardiolipin hydrolase (periplasm, n-C14:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CLPNH140pp"]}, "metabolites": {"clpn140_p": -1.0, "h2o_p": -1.0, "pg140_p": 1.0, "h_p": 1.0, "pa140_p": 1.0}, "id": "CLPNH140pp", "gene_reaction_rule": ""}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Cardiolipin hydrolase (periplasm, n-C14:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CLPNH141pp"]}, "metabolites": {"h2o_p": -1.0, "pg141_p": 1.0, "clpn141_p": -1.0, "h_p": 1.0, "pa141_p": 1.0}, "id": "CLPNH141pp", "gene_reaction_rule": ""}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Cardiolipin hydrolase (periplasm, n-C16:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CLPNH160pp"]}, "metabolites": {"pg160_p": 1.0, "h2o_p": -1.0, "pa160_p": 1.0, "clpn160_p": -1.0, "h_p": 1.0}, "id": "CLPNH160pp", "gene_reaction_rule": ""}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Cardiolipin hydrolase (periplasm, n-C16:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CLPNH161pp"]}, "metabolites": {"clpn161_p": -1.0, "h2o_p": -1.0, "pa161_p": 1.0, "h_p": 1.0, "pg161_p": 1.0}, "id": "CLPNH161pp", "gene_reaction_rule": ""}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Cardiolipin hydrolase (periplasm, n-C18:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CLPNH180pp"]}, "metabolites": {"pa180_p": 1.0, "h2o_p": -1.0, "clpn180_p": -1.0, "pg180_p": 1.0, "h_p": 1.0}, "id": "CLPNH180pp", "gene_reaction_rule": ""}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Cardiolipin hydrolase (periplasm, n-C18:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CLPNH181pp"]}, "metabolites": {"h2o_p": -1.0, "pg181_p": 1.0, "clpn181_p": -1.0, "h_p": 1.0, "pa181_p": 1.0}, "id": "CLPNH181pp", "gene_reaction_rule": ""}, {"subsystem": "Glycerophospholipid Metabolism", "name": 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{"subsystem": "Nucleotide Salvage Pathway", "name": "Deoxyadenosine deaminase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DADA"]}, "metabolites": {"h_c": -1.0, "dad_2_c": -1.0, "din_c": 1.0, "h2o_c": -1.0, "nh4_c": 1.0}, "id": "DADA", "gene_reaction_rule": "b1623"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Deoxyadenylate kinase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DADK"]}, "metabolites": {"dadp_c": 1.0, "damp_c": -1.0, "atp_c": -1.0, "adp_c": 1.0}, "id": "DADK", "gene_reaction_rule": "b0474"}, {"subsystem": "Transport, Inner Membrane", "name": "Deoxyadenosine transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DADNt2pp"]}, "metabolites": {"dad_2_c": 1.0, "dad_2_p": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "DADNt2pp", "gene_reaction_rule": "b2964 or b2393"}, {"subsystem": "Transport, Outer Membrane", "name": "Deoxyadenosine 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-1000.0, "notes": {"original_bigg_ids": ["DALAtex"]}, "metabolites": {"ala__D_e": -1.0, "ala__D_p": 1.0}, "id": "DALAtex", "gene_reaction_rule": "b0241 or b0929 or b1377 or b2215"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "DAMP transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DAMPtex"]}, "metabolites": {"damp_p": 1.0, "damp_e": -1.0}, "id": "DAMPtex", "gene_reaction_rule": "b0241 or b0929 or b1377 or b2215"}, {"subsystem": "Alternate Carbon Metabolism", "name": "2,3-diaminopropionate amonnia lyase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DAPAL"]}, "metabolites": {"h2o_c": -1.0, "pyr_c": 1.0, "nh4_c": 2.0, "23dappa_c": -1.0}, "id": "DAPAL", "gene_reaction_rule": "b2871"}, {"subsystem": "Threonine and Lysine Metabolism", "name": "Diaminopimelate decarboxylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DAPDC"]}, 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-1.0}, "id": "DDCAtexi", "gene_reaction_rule": "b2344"}, {"subsystem": "Alternate Carbon Metabolism", "name": "2-dehydro-3-deoxygalactonokinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DDGALK"]}, "metabolites": {"adp_c": 1.0, "2dh3dgal6p_c": 1.0, "h_c": 1.0, "atp_c": -1.0, "2dh3dgal_c": -1.0}, "id": "DDGALK", "gene_reaction_rule": "b3693"}, {"subsystem": "Transport, Inner Membrane", "name": "2-dehydro-3-deoxy-D-gluconate transport via proton symport, reversible (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DDGLCNt2rpp"]}, "metabolites": {"2ddglcn_p": -1.0, "2ddglcn_c": 1.0, "h_c": 1.0, "h_p": -1.0}, "id": "DDGLCNt2rpp", "gene_reaction_rule": "b3909"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "2-dehydro-3-deoxy-D-gluconate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DDGLCNtex"]}, "metabolites": {"2ddglcn_p": 1.0, "2ddglcn_e": -1.0}, "id": "DDGLCNtex", "gene_reaction_rule": "b0929 or b1377 or b2215 or b0241"}, {"subsystem": "Alternate Carbon Metabolism", "name": "2-dehydro-3-deoxygluconokinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DDGLK"]}, "metabolites": {"h_c": 1.0, "2ddglcn_c": -1.0, "2ddg6p_c": 1.0, "adp_c": 1.0, "atp_c": -1.0}, "id": "DDGLK", "gene_reaction_rule": "b3526"}, {"subsystem": "Tyrosine, Tryptophan, and Phenylalanine Metabolism", "name": "3-deoxy-D-arabino-heptulosonate 7-phosphate synthetase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DDPA"]}, "metabolites": {"pep_c": -1.0, "e4p_c": -1.0, "pi_c": 1.0, "2dda7p_c": 1.0, "h2o_c": -1.0}, "id": "DDPA", "gene_reaction_rule": "b2601 or b0754 or b1704"}, {"subsystem": "Alternate Carbon Metabolism", "name": "2-dehydro-3-deoxy-6-phosphogalactonate aldolase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DDPGALA"]}, "metabolites": {"2dh3dgal6p_c": -1.0, "pyr_c": 1.0, "g3p_c": 1.0}, "id": "DDPGALA", "gene_reaction_rule": "b4477"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Deoxyguanylate kinase (dGMP:ATP)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DGK1"]}, "metabolites": {"dgdp_c": 1.0, "dgmp_c": -1.0, "atp_c": -1.0, "adp_c": 1.0}, "id": "DGK1", "gene_reaction_rule": "b3648"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "DGMP transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DGMPtex"]}, "metabolites": {"dgmp_e": -1.0, "dgmp_p": 1.0}, "id": "DGMPtex", "gene_reaction_rule": "b0241 or b0929 or b1377 or b2215"}, {"subsystem": "Transport, Inner Membrane", "name": "Deoxyguanosine transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DGSNt2pp"]}, "metabolites": {"dgsn_c": 1.0, "dgsn_p": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "DGSNt2pp", "gene_reaction_rule": "b2964"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Deoxyguanosine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DGSNtex"]}, "metabolites": {"dgsn_p": 1.0, "dgsn_e": -1.0}, "id": "DGSNtex", "gene_reaction_rule": "b0241 or b0929 or b1377 or b2215"}, {"subsystem": "Alternate Carbon Metabolism", "name": "2,3-dehydroadipyl-CoA hydratase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DHACOAH"]}, "metabolites": {"3hadpcoa_c": 1.0, "h2o_c": -1.0, "23dhacoa_c": -1.0}, "id": "DHACOAH", "gene_reaction_rule": "b1393"}, {"subsystem": "Valine, Leucine, and Isoleucine Metabolism", "name": "Dihydroxy-acid dehydratase (2,3-dihydroxy-3-methylbutanoate)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHAD1"]}, "metabolites": {"h2o_c": 1.0, "23dhmb_c": -1.0, "3mob_c": 1.0}, "id": "DHAD1", "gene_reaction_rule": "b3771"}, {"subsystem": "Valine, Leucine, and Isoleucine Metabolism", "name": "Dihydroxy-acid dehydratase (2,3-dihydroxy-3-methylpentanoate)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHAD2"]}, "metabolites": {"23dhmp_c": -1.0, "3mop_c": 1.0, "h2o_c": 1.0}, "id": "DHAD2", "gene_reaction_rule": "b3771"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Dihydroxyacetone phosphotransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHAPT"]}, "metabolites": {"pep_c": -1.0, "pyr_c": 1.0, "dhap_c": 1.0, "dha_c": -1.0}, "id": "DHAPT", "gene_reaction_rule": "b1200 and b1199 and b1198 and b2415 and b2416"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Dihydroxyacetone transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DHAtex"]}, "metabolites": {"dha_e": -1.0, "dha_p": 1.0}, "id": "DHAtex", "gene_reaction_rule": "b0241 or b0929 or b1377 or b2215"}, {"subsystem": "Transport, Inner Membrane", "name": "Dihydroxyacetone transport via facilitated diffusion (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DHAtpp"]}, "metabolites": {"dha_p": -1.0, "dha_c": 1.0}, "id": "DHAtpp", "gene_reaction_rule": ""}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DHBD"]}, "metabolites": {"23dhb_c": 1.0, "nadh_c": 1.0, "h_c": 1.0, "nad_c": -1.0, "23ddhb_c": -1.0}, "id": "DHBD", "gene_reaction_rule": "b0596"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "2,3-dihydroxybenzoate adenylate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHBS"]}, "metabolites": {"23dhb_c": -1.0, "23dhba_c": 1.0, "ppi_c": 1.0, "h_c": -1.0, "atp_c": -1.0}, "id": "DHBS", "gene_reaction_rule": "b0594"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "2,3-dihydroxybenzoylserine hydrolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHBSH"]}, "metabolites": {"23dhb_c": 1.0, "ser__L_c": 1.0, "h2o_c": -1.0, "23dhbzs_c": -1.0}, "id": "DHBSH", "gene_reaction_rule": ""}, {"subsystem": "Alternate Carbon Metabolism", "name": "2,3-dihydroxycinnamate dehydrogenase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHCIND"]}, "metabolites": {"dhcinnm_c": 1.0, "nadh_c": 1.0, "h_c": 1.0, "nad_c": -1.0, "cenchddd_c": -1.0}, "id": "DHCIND", "gene_reaction_rule": "b2541"}, {"subsystem": "Alternate Carbon Metabolism", "name": "2,3-dihydroxycinnamate 1,2-dioxygenase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHCINDO"]}, "metabolites": {"o2_c": -1.0, "hkntd_c": 1.0, "dhcinnm_c": -1.0, "h_c": 1.0}, "id": "DHCINDO", "gene_reaction_rule": "b0348"}, {"subsystem": "Threonine and Lysine Metabolism", "name": "Dihydrodipicolinate reductase (NADPH)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHDPRy"]}, "metabolites": {"thdp_c": 1.0, "23dhdp_c": -1.0, "nadph_c": -1.0, "nadp_c": 1.0, "h_c": -1.0}, "id": "DHDPRy", "gene_reaction_rule": "b0031"}, {"subsystem": "Threonine and Lysine Metabolism", "name": "Dihydrodipicolinate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHDPS"]}, "metabolites": {"aspsa_c": -1.0, "pyr_c": -1.0, "23dhdp_c": 1.0, "h2o_c": 2.0, "h_c": 1.0}, "id": "DHDPS", "gene_reaction_rule": "b2478"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Dihydrofolate reductase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DHFR"]}, "metabolites": {"dhf_c": -1.0, "nadp_c": 1.0, "nadph_c": -1.0, "h_c": -1.0, "thf_c": 1.0}, "id": "DHFR", "gene_reaction_rule": "b1606 or 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"id": "DHNAOT4", "gene_reaction_rule": "b3930"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "1,4-dihydroxy-2-napthoyl-CoA synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHNCOAS"]}, "metabolites": {"sbzcoa_c": -1.0, "h2o_c": 1.0, "h_c": -1.0, "14dhncoa_c": 1.0}, "id": "DHNCOAS", "gene_reaction_rule": "b2262"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "1,4-dihydroxy-2-napthoyl-CoA thioesterase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHNCOAT"]}, "metabolites": {"h2o_c": -1.0, "dhna_c": 1.0, "coa_c": 1.0, "h_c": 1.0, "14dhncoa_c": -1.0}, "id": "DHNCOAT", "gene_reaction_rule": "b0736"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Dihydroneopterin aldolase reversible", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DHNPA2r"]}, "metabolites": {"dhnpt_c": -1.0, "6hmhpt_c": 1.0, "gcald_c": 1.0}, "id": "DHNPA2r", "gene_reaction_rule": "b3058"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Dihydroneopterin epimerase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DHNPTE"]}, "metabolites": {"dhnpt_c": -1.0, "dhmpt_c": 1.0}, "id": "DHNPTE", "gene_reaction_rule": "b3058"}, {"subsystem": "Purine and Pyrimidine Biosynthesis", "name": "Dihydoorotic acid dehydrogenase (quinone8)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHORD2"]}, "metabolites": {"q8h2_c": 1.0, "dhor__S_c": -1.0, "q8_c": -1.0, "orot_c": 1.0}, "id": "DHORD2", "gene_reaction_rule": "b0945"}, {"subsystem": "Purine and Pyrimidine Biosynthesis", "name": "Dihydroorotic acid (menaquinone-8)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHORD5"]}, "metabolites": {"dhor__S_c": -1.0, "mqn8_c": -1.0, "mql8_c": 1.0, "orot_c": 1.0}, "id": "DHORD5", "gene_reaction_rule": "b0945"}, {"subsystem": "Purine and Pyrimidine Biosynthesis", "name": "Fumarate dependent DHORD", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHORDfum"]}, "metabolites": {"fum_c": -1.0, "succ_c": 1.0, "dhor__S_c": -1.0, "orot_c": 1.0}, "id": "DHORDfum", "gene_reaction_rule": ""}, {"subsystem": "Purine and Pyrimidine Biosynthesis", "name": "Dihydroorotase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DHORTS"]}, "metabolites": {"cbasp_c": 1.0, "h2o_c": -1.0, "dhor__S_c": -1.0, "h_c": 1.0}, "id": "DHORTS", "gene_reaction_rule": "b1062"}, {"subsystem": "Alternate Carbon Metabolism", "name": "2,3-dihydroxyphenylpropionate dehydrogenase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHPPD"]}, "metabolites": {"cechddd_c": -1.0, "dhpppn_c": 1.0, "nadh_c": 1.0, "h_c": 1.0, "nad_c": -1.0}, "id": "DHPPD", "gene_reaction_rule": "b2541"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Diaminohydroxyphosphoribosylaminopryrimidine deaminase (25drapp)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHPPDA2"]}, "metabolites": {"h_c": -1.0, "5apru_c": 1.0, "h2o_c": -1.0, "nh4_c": 1.0, "25drapp_c": -1.0}, "id": "DHPPDA2", "gene_reaction_rule": "b0414"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Dihydropteroate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHPS2"]}, "metabolites": {"dhpt_c": 1.0, "6hmhptpp_c": -1.0, "ppi_c": 1.0, "4abz_c": -1.0}, "id": "DHPS2", "gene_reaction_rule": "b3177"}, {"subsystem": "Methionine Metabolism", "name": "4,5-dihydroxy-2,3-pentanedione cyclization (spontaneous)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHPTDCs2"]}, "metabolites": {"dhptd_c": -1.0, "mdhdhf_c": 1.0}, "id": "DHPTDCs2", "gene_reaction_rule": "s0001"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Dihydropteridine reductase", 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"b1288"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "Enoyl-[acyl-carrier-protein] reductase (NADH) (n-C6:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EAR60x"]}, "metabolites": {"thex2eACP_c": -1.0, "nad_c": 1.0, "hexACP_c": 1.0, "h_c": -1.0, "nadh_c": -1.0}, "id": "EAR60x", "gene_reaction_rule": "b1288"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "Enoyl-[acyl-carrier-protein] reductase (NADPH) (n-C6:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EAR60y"]}, "metabolites": {"thex2eACP_c": -1.0, "hexACP_c": 1.0, "nadp_c": 1.0, "h_c": -1.0, "nadph_c": -1.0}, "id": "EAR60y", "gene_reaction_rule": "b1288"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "Enoyl-[acyl-carrier-protein] reductase (NADH) (n-C8:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EAR80x"]}, "metabolites": {"ocACP_c": 1.0, "toct2eACP_c": -1.0, "h_c": -1.0, "nad_c": 1.0, "nadh_c": -1.0}, "id": "EAR80x", "gene_reaction_rule": "b1288"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "Enoyl-[acyl-carrier-protein] reductase (NADPH) (n-C8:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EAR80y"]}, "metabolites": {"nadph_c": -1.0, "ocACP_c": 1.0, "nadp_c": 1.0, "h_c": -1.0, "toct2eACP_c": -1.0}, "id": "EAR80y", "gene_reaction_rule": "b1288"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "Enterobacterial common antigen (x4) core oligosaccharide lipid A transport via ABC system (periplasm to extracellular)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ECA4COLIPAabctex"]}, "metabolites": {"eca4colipa_e": 1.0, "h2o_c": -1.0, "atp_c": -1.0, "eca4colipa_p": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0}, "id": "ECA4COLIPAabctex", "gene_reaction_rule": "b3200 and b3201 and b3199 and b4261 and b4262"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "Enterobacterial common 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"name": "Endotoxin Synthesis (lauroyl transferase)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EDTXS1"]}, "metabolites": {"kdo2lipid4_c": -1.0, "kdo2lipid4L_c": 1.0, "ACP_c": 1.0, "ddcaACP_c": -1.0}, "id": "EDTXS1", "gene_reaction_rule": "b1054"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "Endotoxin Synthesis (myristoyl transferase)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EDTXS2"]}, "metabolites": {"kdo2lipid4L_c": -1.0, "ACP_c": 1.0, "lipa_c": 1.0, "myrsACP_c": -1.0}, "id": "EDTXS2", "gene_reaction_rule": "b1855"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "Endotoxin Synthesis (palmitoleoyl ACP)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EDTXS3"]}, "metabolites": {"kdo2lipid4_c": -1.0, "ACP_c": 1.0, "kdo2lipid4p_c": 1.0, "hdeACP_c": -1.0}, "id": "EDTXS3", "gene_reaction_rule": "b2378"}, {"subsystem": "Lipopolysaccharide 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{"subsystem": "Transport, Inner Membrane", "name": "Ethanolamine transport in via proton symport", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ETHAt2pp"]}, "metabolites": {"h_p": -1.0, "etha_p": -1.0, "etha_c": 1.0, "h_c": 1.0}, "id": "ETHAt2pp", "gene_reaction_rule": ""}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Ethanolamine transport via diffusion (extracellular)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ETHAtex"]}, "metabolites": {"etha_e": -1.0, "etha_p": 1.0}, "id": "ETHAtex", "gene_reaction_rule": "b0241 or b0929 or b1377 or b2215"}, {"subsystem": "Transport, Inner Membrane", "name": "Ethanesulfonate transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ETHSO3abcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "ethso3_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "ethso3_p": -1.0}, "id": "ETHSO3abcpp", "gene_reaction_rule": 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"name": "Ferrichrome reductase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["FECRMR3"]}, "metabolites": {"rbflvrd_c": -1.0, "fe2_c": 2.0, "fecrm_c": -2.0, "fecrm_un_c": 2.0, "ribflv_c": 1.0, "h_c": 2.0}, "id": "FECRMR3", "gene_reaction_rule": ""}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Ferrichrome (minus Fe) secretion (to extracellular)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["FECRMUtex"]}, "metabolites": {"fecrm_un_e": 1.0, "h_p": -1.0, "fecrm_un_p": -1.0, "h_c": 1.0}, "id": "FECRMUtex", "gene_reaction_rule": ""}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Ferrichrome (minus Fe) secretion (to periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["FECRMUtpp"]}, "metabolites": {"h_c": 1.0, "fecrm_un_p": 1.0, "h_p": -1.0, "fecrm_un_c": -1.0}, "id": "FECRMUtpp", "gene_reaction_rule": ""}, {"subsystem": "Inorganic Ion Transport and 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"lower_bound": 0.0, "notes": {"original_bigg_ids": ["FEENTERtex"]}, "metabolites": {"enter_e": 1.0, "enter_p": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "FEENTERtex", "gene_reaction_rule": "b3035"}, {"subsystem": "Transport, Outer Membrane", "name": "Fe-enterobactin transport via ton system (extracellular)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["FEENTERtonex"]}, "metabolites": {"feenter_e": -1.0, "h_c": 1.0, "h_p": -1.0, "feenter_p": 1.0}, "id": "FEENTERtonex", "gene_reaction_rule": "b0584 and (b1252 and b3005 and b3006)"}, {"subsystem": "Transport, Inner Membrane", "name": "Enterochelin transport (secretion)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["FEENTERtpp"]}, "metabolites": {"enter_p": 1.0, "h_c": 1.0, "h_p": -1.0, "enter_c": -1.0}, "id": "FEENTERtpp", "gene_reaction_rule": "b0591"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Ferroxamine reductase", "upper_bound": 1000.0, "lower_bound": 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"gene_reaction_rule": "b3452 and b3453 and b3450 and b3451"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Glycero-3-phosphocholine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["G3PCtex"]}, "metabolites": {"g3pc_e": -1.0, "g3pc_p": 1.0}, "id": "G3PCtex", "gene_reaction_rule": "b0241 or b0929 or b1377 or b2215"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Glycerol-3-phosphate dehydrogenase (NADP)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["G3PD2"]}, "metabolites": {"glyc3p_c": -1.0, "nadp_c": -1.0, "nadph_c": 1.0, "h_c": 1.0, "dhap_c": 1.0}, "id": "G3PD2", "gene_reaction_rule": "b3608"}, {"subsystem": "Oxidative Phosphorylation", "name": "Glycerol-3-phosphate dehydrogenase (ubiquinone-8)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["G3PD5"]}, "metabolites": {"q8h2_c": 1.0, "glyc3p_c": -1.0, "dhap_c": 1.0, "q8_c": -1.0}, "id": "G3PD5", "gene_reaction_rule": "(b2241 and b2242 and b2243) or b3426"}, {"subsystem": "Oxidative Phosphorylation", "name": "Glycerol-3-phosphate dehydrogenase (menaquinone-8)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["G3PD6"]}, "metabolites": {"glyc3p_c": -1.0, "dhap_c": 1.0, "mqn8_c": -1.0, "mql8_c": 1.0}, "id": "G3PD6", "gene_reaction_rule": "b2241 and b2242 and b2243"}, {"subsystem": "Oxidative Phosphorylation", "name": "Glycerol-3-phosphate dehydrogenase (demethylmenaquinone-8)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["G3PD7"]}, "metabolites": {"glyc3p_c": -1.0, "dhap_c": 1.0, "2dmmq8_c": -1.0, "2dmmql8_c": 1.0}, "id": "G3PD7", "gene_reaction_rule": "b2241 and b2242 and b2243"}, {"subsystem": "Transport, Inner Membrane", "name": "Sn-glycerol-3-phosphoethanolamine transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["G3PEabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "g3pe_c": 1.0, "g3pe_p": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0}, "id": "G3PEabcpp", "gene_reaction_rule": "b3452 and b3453 and b3450 and b3451"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Glycero-3-phosphoethanolamine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["G3PEtex"]}, "metabolites": {"g3pe_e": -1.0, "g3pe_p": 1.0}, "id": "G3PEtex", "gene_reaction_rule": "b0929 or b1377 or b2215 or b0241"}, {"subsystem": "Transport, Inner Membrane", "name": "Sn-glycerol-3-phosphoglycerol transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["G3PGabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "g3pg_p": -1.0, "g3pg_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0}, "id": "G3PGabcpp", "gene_reaction_rule": "b3452 and b3453 and b3450 and b3451"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Glycerophoglycerol transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["G3PGtex"]}, "metabolites": {"g3pg_p": 1.0, "g3pg_e": -1.0}, "id": "G3PGtex", "gene_reaction_rule": "b0241 or b0929 or b1377 or b2215"}, {"subsystem": "Transport, Inner Membrane", "name": "Sn-glycerol-3-phosphoethanolamine transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["G3PIabcpp"]}, "metabolites": {"g3pi_p": -1.0, "h2o_c": -1.0, "atp_c": -1.0, "g3pi_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0}, "id": "G3PIabcpp", "gene_reaction_rule": "b3452 and b3453 and b3450 and b3451"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Glycero-3-phospho-1-inositol transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["G3PItex"]}, "metabolites": {"g3pi_p": 1.0, "g3pi_e": -1.0}, "id": "G3PItex", "gene_reaction_rule": "b0241 or b0929 or b1377 or b2215"}, {"subsystem": "Transport, Inner Membrane", "name": "Sn-glycerol-3-phosphoserine transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["G3PSabcpp"]}, "metabolites": {"h2o_c": -1.0, "g3ps_c": 1.0, "atp_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "g3ps_p": -1.0, "pi_c": 1.0}, "id": "G3PSabcpp", "gene_reaction_rule": "b3452 and b3453 and b3450 and b3451"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Glycerophosphserine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["G3PStex"]}, "metabolites": {"g3ps_e": -1.0, "g3ps_p": 1.0}, "id": "G3PStex", "gene_reaction_rule": "b0241 or b0929 or b1377 or b2215"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Glycerol-3-phosphatase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["G3PT"]}, "metabolites": {"h2o_c": -1.0, "pi_c": 1.0, "glyc3p_c": -1.0, "glyc_c": 1.0}, "id": "G3PT", "gene_reaction_rule": "b0822"}, {"subsystem": "Arginine and Proline Metabolism", "name": "L-glutamate 5-semialdehyde dehydratase (spontaneous)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["G5SADs"]}, "metabolites": {"1pyr5c_c": 1.0, "glu5sa_c": -1.0, "h2o_c": 1.0, "h_c": 1.0}, "id": "G5SADs", "gene_reaction_rule": "s0001"}, {"subsystem": "Arginine and Proline Metabolism", "name": "Glutamate-5-semialdehyde dehydrogenase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["G5SD"]}, "metabolites": {"glu5sa_c": 1.0, "nadp_c": 1.0, "nadph_c": -1.0, "h_c": -1.0, "pi_c": 1.0, "glu5p_c": -1.0}, "id": "G5SD", "gene_reaction_rule": "b0243"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Glucosamine-6-phosphate deaminase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["G6PDA"]}, 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"GAL1Ptex", "gene_reaction_rule": "b0241 or b0929 or b1377 or b2215"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Beta D-galactose transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GALBDtex"]}, "metabolites": {"gal_bD_e": -1.0, "gal_bD_p": 1.0}, "id": "GALBDtex", "gene_reaction_rule": "b0241 or b0929 or b1377 or b2215"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Galactarate dehydratase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GALCTD"]}, "metabolites": {"h2o_c": 1.0, "5dh4dglc_c": 1.0, "galct__D_c": -1.0}, "id": "GALCTD", "gene_reaction_rule": "b3128"}, {"subsystem": "Alternate Carbon Metabolism", "name": "L-galactonate oxidoreductase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GALCTLO"]}, "metabolites": {"galctn__L_c": -1.0, "nadh_c": 1.0, "tagur_c": 1.0, "h_c": 1.0, "nad_c": -1.0}, "id": "GALCTLO", "gene_reaction_rule": "b4358"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Galactonate dehydratase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GALCTND"]}, "metabolites": {"galctn__D_c": -1.0, "h2o_c": 1.0, "2dh3dgal_c": 1.0}, "id": "GALCTND", "gene_reaction_rule": "b4478"}, {"subsystem": "Transport, Inner Membrane", "name": "L-galactonate transport via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GALCTNLt2pp"]}, "metabolites": {"galctn__L_c": 1.0, "galctn__L_p": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "GALCTNLt2pp", "gene_reaction_rule": "b4356"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "L-galactonate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GALCTNLtex"]}, "metabolites": {"galctn__L_p": 1.0, "galctn__L_e": -1.0}, "id": "GALCTNLtex", "gene_reaction_rule": "b2215 or b1377 or b0929 or b0241"}, {"subsystem": "Transport, Inner Membrane", "name": "D-galactonate transport via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GALCTNt2pp"]}, "metabolites": {"galctn__D_c": 1.0, "galctn__D_p": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "GALCTNt2pp", "gene_reaction_rule": "b3691"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "D-galactonate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GALCTNtex"]}, "metabolites": {"galctn__D_p": 1.0, "galctn__D_e": -1.0}, "id": "GALCTNtex", "gene_reaction_rule": "b0241 or b0929 or b1377 or b2215"}, {"subsystem": "Transport, Inner Membrane", "name": "D-galactarte transport via proton symport, reversible (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GALCTt2rpp"]}, "metabolites": {"h_p": -1.0, "galct__D_c": 1.0, "galct__D_p": -1.0, "h_c": 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"Alternate Carbon Metabolism", "name": "A-galactosidase (melibiose)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GALS3"]}, "metabolites": {"glc__D_c": 1.0, "h2o_c": -1.0, "gal_c": 1.0, "melib_c": -1.0}, "id": "GALS3", "gene_reaction_rule": "b4119"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "Galactosyltransferase I (LPS core synthesis)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GALT1"]}, "metabolites": {"udpg_c": -1.0, "udp_c": 1.0, "gagicolipa_c": 1.0, "h_c": 1.0, "gicolipa_c": -1.0}, "id": "GALT1", "gene_reaction_rule": "b3628"}, {"subsystem": "Transport, Inner Membrane", "name": "Galactitol transport via PEP:Pyr PTS (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GALTptspp"]}, "metabolites": {"pep_c": -1.0, "pyr_c": 1.0, "galt1p_c": 1.0, "galt_p": -1.0}, "id": "GALTptspp", "gene_reaction_rule": "b2094 and b2093 and b2092 and b2415 and b2416"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Galactitol transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GALTtex"]}, "metabolites": {"galt_e": -1.0, "galt_p": 1.0}, "id": "GALTtex", "gene_reaction_rule": "b0241 or b0929 or b1377 or b2215"}, {"subsystem": "Transport, Inner Membrane", "name": "D-galacturonate transport via proton symport, reversible (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GALURt2rpp"]}, "metabolites": {"galur_c": 1.0, "h_c": 1.0, "h_p": -1.0, "galur_p": -1.0}, "id": "GALURt2rpp", "gene_reaction_rule": "b3093"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "D-galacturonate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GALURtex"]}, "metabolites": {"galur_e": -1.0, "galur_p": 1.0}, "id": "GALURtex", "gene_reaction_rule": 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(Glycerophosphoserine)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GPDDA3pp"]}, "metabolites": {"g3ps_p": -1.0, "glyc3p_p": 1.0, "ser__L_p": 1.0, "h_p": 1.0, "h2o_p": -1.0}, "id": "GPDDA3pp", "gene_reaction_rule": "b2239"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Glycerophosphodiester phosphodiesterase (Glycerophosphoglycerol)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GPDDA4"]}, "metabolites": {"g3pg_c": -1.0, "glyc3p_c": 1.0, "glyc_c": 1.0, "h2o_c": -1.0, "h_c": 1.0}, "id": "GPDDA4", "gene_reaction_rule": "b3449"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Glycerophosphodiester phosphodiesterase (Glycerophosphoglycerol)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GPDDA4pp"]}, "metabolites": {"glyc3p_p": 1.0, "g3pg_p": -1.0, "h_p": 1.0, "glyc_p": 1.0, "h2o_p": -1.0}, "id": "GPDDA4pp", "gene_reaction_rule": "b2239"}, {"subsystem": "Glycerophospholipid 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"Transport, Inner Membrane", "name": "H2O transport via diffusion (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["H2Otpp"]}, "metabolites": {"h2o_p": -1.0, "h2o_c": 1.0}, "id": "H2Otpp", "gene_reaction_rule": "s0001 or b0875"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Hydrogen sulfide oxidation", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["H2SO"]}, "metabolites": {"o2_c": -2.0, "h_c": 2.0, "h2s_c": -1.0, "so4_c": 1.0}, "id": "H2SO", "gene_reaction_rule": ""}, {"subsystem": "Transport, Inner Membrane", "name": "H2s transport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["H2St1pp"]}, "metabolites": {"h2s_p": 1.0, "h2s_c": -1.0}, "id": "H2St1pp", "gene_reaction_rule": "s0001"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "H2s transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["H2Stex"]}, "metabolites": {"h2s_e": -1.0, "h2s_p": 1.0}, "id": "H2Stex", "gene_reaction_rule": "b0241 or b0929 or b1377 or b2215"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Hydrogen transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["H2tex"]}, "metabolites": {"h2_e": -1.0, "h2_p": 1.0}, "id": "H2tex", "gene_reaction_rule": "b0241 or b0929 or b1377 or b2215"}, {"subsystem": "Transport, Inner Membrane", "name": "Hydrogen transport diffusion (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["H2tpp"]}, "metabolites": {"h2_c": 1.0, "h2_p": -1.0}, "id": "H2tpp", "gene_reaction_rule": "s0001"}, {"subsystem": "Membrane Lipid Metabolism", "name": "3-hydroxyacyl-CoA dehydrogenase (acetoacetyl-CoA)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["HACD1"]}, "metabolites": {"aacoa_c": -1.0, "3hbcoa_c": 1.0, "nadh_c": -1.0, "h_c": -1.0, "nad_c": 1.0}, "id": "HACD1", "gene_reaction_rule": "b3846 or b2341"}, {"subsystem": "Membrane Lipid Metabolism", "name": "3-hydroxyacyl-CoA dehydrogenase (3-oxohexanoyl-CoA)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["HACD2"]}, "metabolites": {"3hhcoa_c": 1.0, "nadh_c": -1.0, "h_c": -1.0, "nad_c": 1.0, "3ohcoa_c": -1.0}, "id": "HACD2", "gene_reaction_rule": "b3846 or b2341"}, {"subsystem": "Membrane Lipid Metabolism", "name": "3-hydroxyacyl-CoA dehydrogenase (3-oxooctanoyl-CoA)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["HACD3"]}, "metabolites": {"3oocoa_c": -1.0, "nadh_c": -1.0, "h_c": -1.0, "nad_c": 1.0, "3hocoa_c": 1.0}, "id": "HACD3", "gene_reaction_rule": "b3846 or b2341"}, {"subsystem": "Membrane Lipid Metabolism", "name": "3-hydroxyacyl-CoA dehydrogenase (3-oxodecanoyl-CoA)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["HACD4"]}, "metabolites": {"3odcoa_c": -1.0, "nadh_c": -1.0, "3hdcoa_c": 1.0, "h_c": -1.0, "nad_c": 1.0}, "id": "HACD4", "gene_reaction_rule": "b3846 or b2341"}, {"subsystem": "Membrane Lipid Metabolism", "name": "3-hydroxyacyl-CoA dehydrogenase (3-oxododecanoyl-CoA)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["HACD5"]}, "metabolites": {"3oddcoa_c": -1.0, "nadh_c": -1.0, "h_c": -1.0, "nad_c": 1.0, "3hddcoa_c": 1.0}, "id": "HACD5", "gene_reaction_rule": "b3846 or b2341"}, {"subsystem": "Membrane Lipid Metabolism", "name": "3-hydroxyacyl-CoA dehydrogenase (3-oxotetradecanoyl-CoA)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["HACD6"]}, "metabolites": {"3htdcoa_c": 1.0, "3otdcoa_c": -1.0, "nadh_c": -1.0, "h_c": -1.0, "nad_c": 1.0}, "id": "HACD6", "gene_reaction_rule": "b3846 or b2341"}, {"subsystem": "Membrane Lipid Metabolism", "name": "3-hydroxyacyl-CoA dehydrogenase (3-oxohexadecanoyl-CoA)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["HACD7"]}, "metabolites": {"h_c": -1.0, "nadh_c": -1.0, "nad_c": 1.0, "3ohdcoa_c": -1.0, "3hhdcoa_c": 1.0}, "id": "HACD7", "gene_reaction_rule": "b3846 or b2341"}, {"subsystem": "Membrane Lipid Metabolism", "name": "3-hydroxyacyl-CoA dehydrogenase (3-oxooctadecanoyl-CoA), peroxisomal", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["HACD8"]}, "metabolites": {"3hodcoa_c": 1.0, "3oodcoa_c": -1.0, "nadh_c": -1.0, "h_c": -1.0, "nad_c": 1.0}, "id": "HACD8", "gene_reaction_rule": "b3846 or b2341"}, {"subsystem": "Alternate Carbon Metabolism", "name": "3-hydroxyadipyl-CoA dehydrogenase (NAD+)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["HADPCOADH3"]}, "metabolites": {"3hadpcoa_c": -1.0, "nadh_c": 1.0, "oxadpcoa_c": 1.0, "nad_c": -1.0, "h_c": 1.0}, "id": "HADPCOADH3", "gene_reaction_rule": "b1395"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Hydroxybenzoate octaprenyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HBZOPT"]}, "metabolites": {"4hbz_c": -1.0, "3ophb_c": 1.0, "ppi_c": 1.0, "octdp_c": -1.0}, "id": "HBZOPT", "gene_reaction_rule": "b4040"}, {"subsystem": "Transport, Inner Membrane", "name": "3-hydroxycinnamic acid transport via proton symport, reversible (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["HCINNMt2rpp"]}, "metabolites": {"h_p": -1.0, "3hcinnm_c": 1.0, "3hcinnm_p": -1.0, "h_c": 1.0}, "id": "HCINNMt2rpp", "gene_reaction_rule": "b0353"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "3-hydroxycinnamic acid transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["HCINNMtex"]}, "metabolites": {"3hcinnm_e": -1.0, "3hcinnm_p": 1.0}, "id": "HCINNMtex", "gene_reaction_rule": "b0241 or b0929 or b1377 or b2215"}, {"subsystem": "Unassigned", "name": "HCO3 equilibration reaction", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["HCO3E"]}, "metabolites": {"hco3_c": 1.0, "h2o_c": -1.0, "co2_c": -1.0, "h_c": 1.0}, "id": "HCO3E", "gene_reaction_rule": "b0126 or b0339"}, {"subsystem": "Methionine Metabolism", "name": "Homocysteine S-methyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HCYSMT"]}, "metabolites": {"hcys__L_c": -1.0, "amet_c": -1.0, "ahcys_c": 1.0, "h_c": 1.0, "met__L_c": 1.0}, "id": "HCYSMT", "gene_reaction_rule": "b0261"}, {"subsystem": "Methionine Metabolism", "name": "Homocysteine Methyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HCYSMT2"]}, "metabolites": {"hcys__L_c": -1.0, "h_c": 1.0, "met__L_c": 2.0, "mmet_c": -1.0}, "id": "HCYSMT2", "gene_reaction_rule": "b0261"}, {"subsystem": "Transport, Outer Membrane", "name": "Hexadecanoate transport via facilitated irreversible diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HDCAtexi"]}, "metabolites": {"hdca_e": -1.0, "hdca_p": 1.0}, "id": "HDCAtexi", "gene_reaction_rule": "b2344"}, {"subsystem": "Transport, Outer Membrane", "name": "Hexadecenoate transport via facilitated irreversible diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HDCEAtexi"]}, "metabolites": {"hdcea_p": 1.0, "hdcea_e": -1.0}, "id": "HDCEAtexi", "gene_reaction_rule": "b2344"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Heme O synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HEMEOS"]}, "metabolites": {"ppi_c": 1.0, "hemeO_c": 1.0, "frdp_c": -1.0, "h2o_c": -1.0, "pheme_c": -1.0}, "id": "HEMEOS", "gene_reaction_rule": "b0428"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "LPS heptose kinase I (LPS core synthesis)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HEPK1"]}, "metabolites": {"hhlipa_c": -1.0, "phhlipa_c": 1.0, "atp_c": -1.0, "adp_c": 1.0, "h_c": 1.0}, "id": "HEPK1", "gene_reaction_rule": "b3630"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "LPS heptose kinase II (LPS core synthesis)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HEPK2"]}, "metabolites": {"hphhlipa_c": -1.0, "phphhlipa_c": 1.0, "h_c": 1.0, "atp_c": -1.0, "adp_c": 1.0}, "id": "HEPK2", "gene_reaction_rule": "b3625"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "Heptosyltransferase I (LPS core synthesis)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HEPT1"]}, "metabolites": {"h_c": 1.0, "lipa_c": -1.0, "hlipa_c": 1.0, "adp_c": 1.0, "adphep_LD_c": -1.0}, "id": "HEPT1", "gene_reaction_rule": "b3621"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "Heptosyltransferase II (LPS core synthesis)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HEPT2"]}, "metabolites": {"adp_c": 1.0, "hhlipa_c": 1.0, "h_c": 1.0, "adphep_LD_c": -1.0, "hlipa_c": -1.0}, "id": "HEPT2", "gene_reaction_rule": "b3620"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "Heptosyltransferase III (LPS core synthesis)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HEPT3"]}, "metabolites": {"hphhlipa_c": 1.0, "phhlipa_c": -1.0, "h_c": 1.0, "adphep_LD_c": -1.0, "adp_c": 1.0}, "id": "HEPT3", "gene_reaction_rule": "b3632"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "Heptosyltransferase IV (LPS core synthesis)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HEPT4"]}, "metabolites": {"colipa_c": 1.0, "gggagicolipa_c": -1.0, "adphep_LD_c": -1.0, "adp_c": 1.0, "h_c": 1.0}, "id": "HEPT4", "gene_reaction_rule": "b3623"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Hydroxyethylthiazole kinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HETZK"]}, "metabolites": {"4mhetz_c": -1.0, "4mpetz_c": 1.0, "atp_c": -1.0, "adp_c": 1.0, "h_c": 1.0}, "id": "HETZK", "gene_reaction_rule": "b2104"}, {"subsystem": "Glycolysis/Gluconeogenesis", "name": "Hexokinase (D-glucose:ATP)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HEX1"]}, "metabolites": {"glc__D_c": -1.0, "g6p_c": 1.0, "h_c": 1.0, "atp_c": -1.0, "adp_c": 1.0}, "id": "HEX1", "gene_reaction_rule": "b2388"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Hexokinase (D-mannose:ATP)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HEX4"]}, "metabolites": {"adp_c": 1.0, "man6p_c": 1.0, "h_c": 1.0, "atp_c": -1.0, "man_c": -1.0}, "id": "HEX4", "gene_reaction_rule": ""}, {"subsystem": "Alternate Carbon Metabolism", "name": "Hexokinase (D-fructose:ATP)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HEX7"]}, "metabolites": {"adp_c": 1.0, "fru_c": -1.0, "h_c": 1.0, "atp_c": -1.0, "f6p_c": 1.0}, "id": "HEX7", "gene_reaction_rule": "b0394"}, {"subsystem": "Transport, Inner Membrane", "name": "Hexanoate transport via proton symport, reversible (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["HEXt2rpp"]}, "metabolites": {"hxa_p": -1.0, "hxa_c": 1.0, "h_c": 1.0, "h_p": -1.0}, "id": "HEXt2rpp", "gene_reaction_rule": "b2223"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Mercury (Hg+2) ABC transporter (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HG2abcpp"]}, "metabolites": {"h2o_c": -1.0, "hg2_p": 1.0, "atp_c": -1.0, "hg2_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0}, "id": "HG2abcpp", "gene_reaction_rule": "b3469"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Mercury (Hg+2) transport out via proton antiport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HG2t3pp"]}, "metabolites": {"hg2_c": -1.0, "hg2_p": 1.0, "h_c": 1.0, "h_p": -1.0}, "id": "HG2t3pp", "gene_reaction_rule": "b3915"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Mercury (Hg+2) transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["HG2tex"]}, "metabolites": {"hg2_p": 1.0, "hg2_e": -1.0}, "id": "HG2tex", "gene_reaction_rule": "b0241 or b0929 or b1377 or b2215"}, {"subsystem": "Histidine Metabolism", "name": "Histidinol dehydrogenase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HISTD"]}, "metabolites": {"histd_c": -1.0, "h2o_c": -1.0, "his__L_c": 1.0, "h_c": 3.0, "nad_c": -2.0, "nadh_c": 2.0}, "id": "HISTD", "gene_reaction_rule": "b2020"}, {"subsystem": "Histidine Metabolism", "name": "Histidinol-phosphatase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HISTP"]}, "metabolites": {"hisp_c": -1.0, "histd_c": 1.0, "h2o_c": -1.0, "pi_c": 1.0}, "id": "HISTP", "gene_reaction_rule": "b2022"}, {"subsystem": "tRNA Charging", "name": "Histidyl-tRNA synthetase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HISTRS"]}, "metabolites": {"histrna_c": 1.0, "atp_c": -1.0, "his__L_c": -1.0, "ppi_c": 1.0, "trnahis_c": -1.0, "amp_c": 1.0}, "id": "HISTRS", "gene_reaction_rule": "b2514"}, {"subsystem": "Transport, Inner Membrane", "name": "L-histidine transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HISabcpp"]}, "metabolites": {"h2o_c": -1.0, "pi_c": 1.0, "atp_c": -1.0, "his__L_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "his__L_p": -1.0}, "id": "HISabcpp", "gene_reaction_rule": "b2309 and b2307 and b2306 and b2308"}, {"subsystem": "Transport, Inner Membrane", "name": "L-histidine reversible transport via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["HISt2rpp"]}, "metabolites": {"his__L_c": 1.0, "his__L_p": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "HISt2rpp", "gene_reaction_rule": "b0112"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "L-histidine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["HIStex"]}, "metabolites": {"his__L_p": 1.0, "his__L_e": -1.0}, "id": "HIStex", "gene_reaction_rule": "b0241 or b0929 or b1377 or b2215"}, {"subsystem": "Alternate Carbon Metabolism", "name": "2-hydroxy-6-ketonona-2,4-dienedioic acid hydrolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HKNDDH"]}, "metabolites": {"h2o_c": -1.0, "hkndd_c": -1.0, "succ_c": 1.0, "h_c": 1.0, "op4en_c": 1.0}, "id": "HKNDDH", "gene_reaction_rule": "b0349"}, {"subsystem": "Alternate Carbon Metabolism", "name": "2-hydroxy-6-ketononotrienedioate hydrolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HKNTDH"]}, "metabolites": {"hkntd_c": -1.0, "h2o_c": -1.0, "fum_c": 1.0, "h_c": 1.0, "op4en_c": 1.0}, "id": "HKNTDH", "gene_reaction_rule": "b0349"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Hydroxymethylbilane synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HMBS"]}, "metabolites": {"ppbng_c": -4.0, "hmbil_c": 1.0, "nh4_c": 4.0, "h2o_c": -1.0}, "id": "HMBS", "gene_reaction_rule": "b3805"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Hydroxymethylpyrimidine kinase (ATP)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HMPK1"]}, "metabolites": {"adp_c": 1.0, "4ampm_c": 1.0, "4ahmmp_c": -1.0, "atp_c": -1.0, "h_c": 1.0}, "id": "HMPK1", "gene_reaction_rule": "b2103 or b2418"}, {"subsystem": "Transport, Inner Membrane", "name": "L-homoserineserine 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(extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["INDOLEtex"]}, "metabolites": {"indole_e": -1.0, "indole_p": 1.0}, "id": "INDOLEtex", "gene_reaction_rule": "b0241 or b0929 or b1377 or b2215"}, {"subsystem": "Transport, Inner Membrane", "name": "Na+/myo-inositol symporter (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["INOSTt4pp"]}, "metabolites": {"na1_p": -1.0, "na1_c": 1.0, "inost_c": 1.0, "inost_p": -1.0}, "id": "INOSTt4pp", "gene_reaction_rule": "b3679"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Inosine hydrolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["INSH"]}, "metabolites": {"rib__D_c": 1.0, "h2o_c": -1.0, "hxan_c": 1.0, "ins_c": -1.0}, "id": "INSH", "gene_reaction_rule": "b0030"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Insosine kinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["INSK"]}, "metabolites": {"ins_c": -1.0, "atp_c": -1.0, "imp_c": 1.0, "adp_c": 1.0, "h_c": 1.0}, "id": "INSK", "gene_reaction_rule": "b0477"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Inositol transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["INSTtex"]}, "metabolites": {"inost_e": -1.0, "inost_p": 1.0}, "id": "INSTtex", "gene_reaction_rule": "b0241 or b0929 or b1377 or b2215"}, {"subsystem": "Transport, Inner Membrane", "name": "Inosine transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["INSt2pp", "INSt2rpp"]}, "metabolites": {"ins_p": -1.0, "h_c": 1.0, "h_p": -1.0, "ins_c": 1.0}, "id": "INSt2pp_copy1", "gene_reaction_rule": "b2964"}, {"subsystem": "Transport, Inner Membrane", "name": "Inosine transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["INSt2pp", "INSt2rpp"]}, "metabolites": {"ins_p": -1.0, "h_c": 1.0, "h_p": -1.0, "ins_c": 1.0}, "id": "INSt2pp_copy2", "gene_reaction_rule": "b2406"}, {"subsystem": "Transport, Outer Membrane", "name": "Inosine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["INStex"]}, "metabolites": {"ins_e": -1.0, "ins_p": 1.0}, "id": "INStex", "gene_reaction_rule": "b0411"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Isopentenyl-diphosphate D-isomerase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["IPDDI"]}, "metabolites": {"dmpp_c": 1.0, "ipdp_c": -1.0}, "id": "IPDDI", "gene_reaction_rule": "b2889"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase (ipdp)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["IPDPS"]}, "metabolites": {"h2o_c": 1.0, "ipdp_c": 1.0, "h2mb4p_c": -1.0, "h_c": -1.0, "nad_c": 1.0, "nadh_c": -1.0}, "id": "IPDPS", "gene_reaction_rule": "b0029"}, {"subsystem": "Valine, Leucine, and Isoleucine Metabolism", "name": "3-isopropylmalate dehydrogenase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["IPMD"]}, "metabolites": {"3c4mop_c": 1.0, "3c2hmp_c": -1.0, "nadh_c": 1.0, "h_c": 1.0, "nad_c": -1.0}, "id": "IPMD", "gene_reaction_rule": "b0073"}, {"subsystem": "Valine, Leucine, and Isoleucine Metabolism", "name": "3-isopropylmalate dehydratase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["IPPMIa"]}, "metabolites": {"3c2hmp_c": -1.0, "h2o_c": 1.0, "2ippm_c": 1.0}, "id": "IPPMIa", "gene_reaction_rule": "b0071 and b0072"}, {"subsystem": "Valine, Leucine, and Isoleucine Metabolism", "name": "2-isopropylmalate hydratase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["IPPMIb"]}, "metabolites": {"2ippm_c": -1.0, "h2o_c": -1.0, "3c3hmp_c": 1.0}, "id": "IPPMIb", "gene_reaction_rule": "b0071 and b0072"}, {"subsystem": "Valine, Leucine, and Isoleucine Metabolism", "name": "2-isopropylmalate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["IPPS"]}, "metabolites": {"h2o_c": -1.0, "accoa_c": -1.0, "3mob_c": -1.0, "coa_c": 1.0, "h_c": 1.0, "3c3hmp_c": 1.0}, "id": "IPPS", "gene_reaction_rule": "b0074"}, {"subsystem": "Transport, Inner Membrane", "name": "Isethionate transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ISETACabcpp"]}, "metabolites": {"isetac_c": 1.0, "h2o_c": -1.0, "atp_c": -1.0, "isetac_p": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0}, "id": "ISETACabcpp", "gene_reaction_rule": "(b0365 and b0366 and b0367) or (b0936 and b0933 and b0934)"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Isethionate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ISETACtex"]}, "metabolites": {"isetac_p": 1.0, "isetac_e": -1.0}, "id": "ISETACtex", "gene_reaction_rule": "b0241 or b0929 or b1377 or b2215"}, {"subsystem": "Transport, Inner Membrane", "name": "KDO(2)-lipid IV A transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["K2L4Aabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "kdo2lipid4_p": 1.0, "h_c": 1.0, "adp_c": 1.0, "kdo2lipid4_c": -1.0, "pi_c": 1.0}, "id": "K2L4Aabcpp", "gene_reaction_rule": "b0914"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "KDO(2)-lipid IV A transport via ABC system (periplasm to extracellular)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["K2L4Aabctex"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "kdo2lipid4_p": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "kdo2lipid4_e": 1.0}, "id": "K2L4Aabctex", "gene_reaction_rule": "b3200 and b3201 and b3199 and b4261 and b4262"}, {"subsystem": "Valine, Leucine, and Isoleucine Metabolism", "name": "Ketol-acid reductoisomerase (2,3-dihydroxy-3-methylbutanoate)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["KARA1"]}, "metabolites": {"nadp_c": -1.0, "nadph_c": 1.0, "h_c": 1.0, "23dhmb_c": -1.0, "alac__S_c": 1.0}, "id": "KARA1", "gene_reaction_rule": "b3774"}, {"subsystem": "Valine, Leucine, and Isoleucine Metabolism", "name": "Ketol-acid reductoisomerase (2-Acetolactate)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["KARA2"]}, "metabolites": {"2ahbut_c": -1.0, "23dhmp_c": 1.0, "nadp_c": 1.0, "nadph_c": -1.0, "h_c": -1.0}, "id": "KARA2", "gene_reaction_rule": "b3774"}, {"subsystem": "Membrane Lipid Metabolism", "name": "Beta-ketoacyl-ACP synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["KAS14"]}, "metabolites": {"acACP_c": -1.0, "ACP_c": 1.0, "malACP_c": -1.0, "h_c": -1.0, "actACP_c": 1.0, "co2_c": 1.0}, "id": "KAS14", "gene_reaction_rule": "b2323 or b1095"}, {"subsystem": "Membrane Lipid Metabolism", "name": "Beta-ketoacyl-ACP synthase (2)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["KAS15"]}, "metabolites": {"malACP_c": -1.0, "coa_c": 1.0, "h_c": -1.0, "accoa_c": -1.0, "actACP_c": 1.0, "co2_c": 1.0}, "id": "KAS15", "gene_reaction_rule": "b1091"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "3-deoxy-manno-octulosonate cytidylyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["KDOCT2"]}, "metabolites": {"ctp_c": -1.0, "ckdo_c": 1.0, "ppi_c": 1.0, "kdo_c": -1.0}, "id": "KDOCT2", "gene_reaction_rule": "b0918"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "3-deoxy-manno-octulosonate-8-phosphatase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["KDOPP"]}, "metabolites": {"kdo_c": 1.0, "kdo8p_c": -1.0, "h2o_c": -1.0, "pi_c": 1.0}, "id": "KDOPP", "gene_reaction_rule": "b3198"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "3-deoxy -D-manno-octulosonic -acid 8-phosphate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["KDOPS"]}, "metabolites": {"ara5p_c": -1.0, "kdo8p_c": 1.0, "h2o_c": -1.0, "pi_c": 1.0, "pep_c": -1.0}, "id": "KDOPS", "gene_reaction_rule": "b1215"}, {"subsystem": "Alternate Carbon Metabolism", "name": "3-keto-L-gulonate 6-phosphate decarboxylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["KG6PDC"]}, "metabolites": {"3dhgulnp_c": -1.0, "xu5p__L_c": 1.0, "co2_c": 1.0, "h_c": -1.0}, "id": "KG6PDC", "gene_reaction_rule": "b4196 or b3581"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Potassium ABC transporter (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["Kabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "k_p": -1.0, "h_c": 1.0, "adp_c": 1.0, "k_c": 1.0, "pi_c": 1.0}, "id": "Kabcpp", "gene_reaction_rule": "(b0698 and b0697 and b0696) or (b0698 and b0697 and b0696 and b4513)"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Potassium transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["Kt2pp"]}, "metabolites": {"k_p": -1.0, "k_c": 1.0, "h_c": 1.0, "h_p": -1.0}, "id": "Kt2pp", "gene_reaction_rule": "(b1291 and b3290 and b3849) or b1250 or (b1291 and b3290 and b1363) or b3747"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Potassium transport out via proton antiport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["Kt3pp"]}, "metabolites": {"k_p": 1.0, "k_c": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "Kt3pp", "gene_reaction_rule": "b1216 or b0842 or b3350 or b0047"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Potassium transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["Ktex"]}, "metabolites": {"k_p": 1.0, "k_e": -1.0}, "id": "Ktex", "gene_reaction_rule": "b0241 or b0929 or b1377 or b2215"}, {"subsystem": "Oxidative Phosphorylation", "name": "L-Lactate dehydrogenase (ubiquinone)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["L_DASH_LACD2"]}, "metabolites": {"q8h2_c": 1.0, "pyr_c": 1.0, "lac__L_c": -1.0, "q8_c": -1.0}, "id": "L_LACD2", "gene_reaction_rule": "b3605 or (b0306 and b0307 and b0308)"}, {"subsystem": "Oxidative Phosphorylation", "name": "L-Lactate dehydrogenase (menaquinone)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["L_DASH_LACD3"]}, "metabolites": {"mqn8_c": -1.0, "pyr_c": 1.0, "lac__L_c": -1.0, "mql8_c": 1.0}, "id": "L_LACD3", "gene_reaction_rule": "b3605 or (b0306 and b0307 and b0308)"}, {"subsystem": "Transport, Inner Membrane", "name": "L-lactate reversible transport via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["L_DASH_LACt2rpp"]}, "metabolites": {"lac__L_c": 1.0, "h_c": 1.0, "h_p": -1.0, "lac__L_p": -1.0}, "id": "L_LACt2rpp", "gene_reaction_rule": "b3603 or b2975"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "L-lactate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["L_DASH_LACtex"]}, "metabolites": {"lac__L_e": -1.0, "lac__L_p": 1.0}, "id": "L_LACtex", "gene_reaction_rule": "b0929 or b1377 or b2215 or b0241"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "4-amino-4-deoxy-L-arabinotransferase (LPS lipid A modification, periplasmic face of membrane))", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LA4NTpp"]}, "metabolites": {"acolipa_p": 1.0, "colipa_p": -1.0, "uLa4n_p": -1.0, "udcpp_p": 1.0}, "id": "LA4NTpp", "gene_reaction_rule": "b2257"}, {"subsystem": "Alternate Carbon Metabolism", "name": "B-galactosidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LACZ"]}, "metabolites": {"glc__D_c": 1.0, "lcts_c": -1.0, "h2o_c": -1.0, "gal_c": 1.0}, "id": "LACZ", "gene_reaction_rule": "b0344"}, {"subsystem": "Alternate Carbon Metabolism", "name": "B-galactosidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LACZpp"]}, "metabolites": {"gal_p": 1.0, "h2o_p": -1.0, "glc__D_p": 1.0, "lcts_p": -1.0}, "id": "LACZpp", "gene_reaction_rule": "b2132"}, {"subsystem": "Murein Recycling", "name": "L-alanyl-gamma-D-glutamyl-meso-diaminopimelate hydrolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LADGMDH"]}, "metabolites": {"h2o_c": -1.0, "LalaDglu_c": 1.0, "LalaDgluMdap_c": -1.0, "26dap__M_c": 1.0}, "id": "LADGMDH", "gene_reaction_rule": "b1326"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "L-alanyl-D-glutamate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["LALADGLUtex"]}, "metabolites": {"LalaDglu_p": 1.0, "LalaDglu_e": -1.0}, "id": "LALADGLUtex", "gene_reaction_rule": "b2215 or b1377 or b0241 or b0929"}, {"subsystem": "Transport, Inner Membrane", "name": "L-alanyl-D-glutamate transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LALADGLUtpp"]}, "metabolites": {"LalaDglu_p": -1.0, "LalaDglu_c": 1.0, "h_c": 1.0, "h_p": -1.0}, "id": "LALADGLUtpp", "gene_reaction_rule": "b1634 or b3496 or b4130 or b0709"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "L-alanyl-L-glutamate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["LALALGLUtex"]}, "metabolites": {"LalaLglu_p": 1.0, "LalaLglu_e": -1.0}, "id": "LALALGLUtex", 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"lald__L_c": 1.0, "mthgxl_c": -1.0}, "id": "LALDO3", "gene_reaction_rule": ""}, {"subsystem": "Murein Recycling", "name": "L-alanyl-gamma-L-glutamate peptidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LALGP"]}, "metabolites": {"glu__L_c": 1.0, "ala__L_c": 1.0, "LalaLglu_c": -1.0, "h2o_c": -1.0}, "id": "LALGP", "gene_reaction_rule": "b0237"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Lactaldehyde dehydrogenase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LCADi"]}, "metabolites": {"h2o_c": -1.0, "lald__L_c": -1.0, "lac__L_c": 1.0, "h_c": 2.0, "nad_c": -1.0, "nadh_c": 1.0}, "id": "LCADi", "gene_reaction_rule": "b1415"}, {"subsystem": "Methylglyoxal Metabolism", "name": "Lacaldehyde reductase (R-propane-1,2-diol forming)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["LCARR"]}, "metabolites": {"nad_c": 1.0, "nadh_c": -1.0, "h_c": -1.0, "lald__D_c": -1.0, "12ppd__R_c": 1.0}, "id": "LCARR", "gene_reaction_rule": ""}, {"subsystem": "Alternate Carbon Metabolism", "name": "Lacaldehyde reductase (S-propane-1,2-diol forming)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["LCARS"]}, "metabolites": {"nadh_c": -1.0, "12ppd__S_c": 1.0, "nad_c": 1.0, "lald__L_c": -1.0, "h_c": -1.0}, "id": "LCARS", "gene_reaction_rule": "b2799"}, {"subsystem": "Transport, Inner Membrane", "name": "Lactose transport via proton aniport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LCTSt3ipp"]}, "metabolites": {"lcts_c": -1.0, "lcts_p": 1.0, "h_c": 1.0, "h_p": -1.0}, "id": "LCTSt3ipp", "gene_reaction_rule": "b2170 or b0070 or b1528"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Lactose transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["LCTStex"]}, "metabolites": {"lcts_p": 1.0, "lcts_e": -1.0}, "id": "LCTStex", 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"LGTHL", "gene_reaction_rule": "b1651"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "Lipid (cold) A transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LIPACabcpp"]}, "metabolites": {"h2o_c": -1.0, "lipa_cold_c": -1.0, "atp_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "lipa_cold_p": 1.0, "pi_c": 1.0}, "id": "LIPACabcpp", "gene_reaction_rule": "b0914"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "Core oligosaccharide lipid A:hexadecanoate transferase (n-C16:0) (extracellular membrane)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LIPAHT2ex"]}, "metabolites": {"hdca_e": -1.0, "h_e": -1.0, "h2o_e": 1.0, "hacolipa_e": 1.0, "colipa_e": -1.0}, "id": "LIPAHT2ex", "gene_reaction_rule": "b0622"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "Lipid A:hexadecanoate transferase (n-C16:0) (extracellular membrane)", "upper_bound": 1000.0, 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(acyltransferase, 2-acyl-glycerophosphoethanolamine, n-C12:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL2ATE120"]}, "metabolites": {"pg120_c": -1.0, "g3pe_c": 1.0, "2agpe120_c": -1.0, "apg120_c": 1.0}, "id": "LPLIPAL2ATE120", "gene_reaction_rule": "b3825"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L2 (acyltransferase, 2-acyl-glycerophosphoethanolamine, n-C14:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL2ATE140"]}, "metabolites": {"pg140_c": -1.0, "2agpe140_c": -1.0, "apg140_c": 1.0, "g3pe_c": 1.0}, "id": "LPLIPAL2ATE140", "gene_reaction_rule": "b3825"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L2 (acyltransferase, 2-acyl-glycerophosphoethanolamine, n-C14:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL2ATE141"]}, "metabolites": {"pg141_c": -1.0, "apg141_c": 1.0, "2agpe141_c": -1.0, "g3pe_c": 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0.0, "notes": {"original_bigg_ids": ["LPLIPAL2ATE180"]}, "metabolites": {"2agpe180_c": -1.0, "apg180_c": 1.0, "pg180_c": -1.0, "g3pe_c": 1.0}, "id": "LPLIPAL2ATE180", "gene_reaction_rule": "b3825"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L2 (acyltransferase, 2-acyl-glycerophosphoethanolamine, n-C18:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL2ATE181"]}, "metabolites": {"apg181_c": 1.0, "2agpe181_c": -1.0, "pg181_c": -1.0, "g3pe_c": 1.0}, "id": "LPLIPAL2ATE181", "gene_reaction_rule": "b3825"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L2 (acyltransferase, 2-acyl-glycerophosphoglycerol, n-C12:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL2ATG120"]}, "metabolites": {"g3pg_c": 1.0, "apg120_c": 1.0, "2agpg120_c": -1.0, "pg120_c": -1.0}, "id": "LPLIPAL2ATG120", "gene_reaction_rule": "b3825"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L2 (acyltransferase, 2-acyl-glycerophosphoglycerol, n-C14:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL2ATG140"]}, "metabolites": {"g3pg_c": 1.0, "2agpg140_c": -1.0, "apg140_c": 1.0, "pg140_c": -1.0}, "id": "LPLIPAL2ATG140", "gene_reaction_rule": "b3825"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L2 (acyltransferase, 2-acyl-glycerophosphoglycerol, n-C14:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL2ATG141"]}, "metabolites": {"pg141_c": -1.0, "g3pg_c": 1.0, "2agpg141_c": -1.0, "apg141_c": 1.0}, "id": "LPLIPAL2ATG141", "gene_reaction_rule": "b3825"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L2 (acyltransferase, 2-acyl-glycerophosphoglycerol, n-C16:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL2ATG160"]}, "metabolites": {"2agpg160_c": -1.0, "g3pg_c": 1.0, "pg160_c": -1.0, "apg160_c": 1.0}, "id": "LPLIPAL2ATG160", "gene_reaction_rule": "b3825"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L2 (acyltransferase, 2-acyl-glycerophosphoglycerol, n-C16:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL2ATG161"]}, "metabolites": {"2agpg161_c": -1.0, "pg161_c": -1.0, "apg161_c": 1.0, "g3pg_c": 1.0}, "id": "LPLIPAL2ATG161", "gene_reaction_rule": "b3825"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L2 (acyltransferase, 2-acyl-glycerophosphoglycerol, n-C18:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL2ATG180"]}, "metabolites": {"g3pg_c": 1.0, "pg180_c": -1.0, "2agpg180_c": -1.0, "apg180_c": 1.0}, "id": "LPLIPAL2ATG180", "gene_reaction_rule": "b3825"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L2 (acyltransferase, 2-acyl-glycerophosphoglycerol, n-C18:1)", "upper_bound": 1000.0, 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"Lysophospholipase L2 (2-acylglycerophosphoethanolamine, n-C14:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL2E141"]}, "metabolites": {"h2o_c": -1.0, "2agpe141_c": -1.0, "h_c": 1.0, "ttdcea_c": 1.0, "g3pe_c": 1.0}, "id": "LPLIPAL2E141", "gene_reaction_rule": "b3825"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L2 (2-acylglycerophosphoethanolamine, n-C16:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL2E160"]}, "metabolites": {"h2o_c": -1.0, "hdca_c": 1.0, "h_c": 1.0, "2agpe160_c": -1.0, "g3pe_c": 1.0}, "id": "LPLIPAL2E160", "gene_reaction_rule": "b3825"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L2 (2-acylglycerophosphoethanolamine, n-C16:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL2E161"]}, "metabolites": {"hdcea_c": 1.0, "h2o_c": -1.0, "g3pe_c": 1.0, "h_c": 1.0, "2agpe161_c": -1.0}, "id": "LPLIPAL2E161", "gene_reaction_rule": "b3825"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L2 (2-acylglycerophosphoethanolamine, n-C18:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL2E180"]}, "metabolites": {"2agpe180_c": -1.0, "h2o_c": -1.0, "g3pe_c": 1.0, "h_c": 1.0, "ocdca_c": 1.0}, "id": "LPLIPAL2E180", "gene_reaction_rule": "b3825"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L2 (2-acylglycerophosphoethanolamine, n-C18:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL2E181"]}, "metabolites": {"ocdcea_c": 1.0, "h2o_c": -1.0, "2agpe181_c": -1.0, "h_c": 1.0, "g3pe_c": 1.0}, "id": "LPLIPAL2E181", "gene_reaction_rule": "b3825"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L2 (2-acylglycerophosphoglycerol, n-C12:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL2G120"]}, 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"Transport, Inner Membrane", "name": "L-lysine transport out via proton antiport (cytoplasm to periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LYSt3pp"]}, "metabolites": {"lys__L_c": -1.0, "h_c": 1.0, "h_p": -1.0, "lys__L_p": 1.0}, "id": "LYSt3pp", "gene_reaction_rule": "b2923"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "L-lysine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["LYStex"]}, "metabolites": {"lys__L_e": -1.0, "lys__L_p": 1.0}, "id": "LYStex", "gene_reaction_rule": "b0241 or b0929 or b1377 or b2215"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Lyxose isomerase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LYXI"]}, "metabolites": {"xylu__L_c": 1.0, "lyx__L_c": -1.0}, "id": "LYXI", "gene_reaction_rule": "b3903"}, {"subsystem": "Transport, Inner Membrane", "name": "L-Lyxose transport via proton 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["MALTTTRtexi"]}, "metabolites": {"maltttr_e": -1.0, "maltttr_p": 1.0}, "id": "MALTTTRtexi", "gene_reaction_rule": "b4036"}, {"subsystem": "Transport, Inner Membrane", "name": "Maltose transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MALTabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "malt_p": -1.0, "h_c": 1.0, "adp_c": 1.0, "malt_c": 1.0, "pi_c": 1.0}, "id": "MALTabcpp", "gene_reaction_rule": "b4034 and b4033 and b4032 and b4035"}, {"subsystem": "Transport, Inner Membrane", "name": "Maltose transport via PEP:Pyr PTS (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MALTptspp"]}, "metabolites": {"pep_c": -1.0, "malt_p": -1.0, "malt6p_c": 1.0, "pyr_c": 1.0}, "id": "MALTptspp", "gene_reaction_rule": "b2417 and b1621 and b2415 and b2416"}, {"subsystem": "Transport, Outer Membrane", "name": "MaltoseMaltotriose transport via diffusion (extracellular to periplasm) irreversible", 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-1.0, "nadh_c": 1.0, "h_c": 1.0, "nad_c": -1.0, "fruur_c": 1.0}, "id": "MANAO", "gene_reaction_rule": "b4323"}, {"subsystem": "Transport, Inner Membrane", "name": "2-O-alpha-mannosyl-D-glycerate transport via PEP:Pyr PTS (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MANGLYCptspp"]}, "metabolites": {"pep_c": -1.0, "man6pglyc_c": 1.0, "pyr_c": 1.0, "manglyc_p": -1.0}, "id": "MANGLYCptspp", "gene_reaction_rule": "b0731 and b2415 and b2416"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "2-O-alpha-mannosyl-D-glycerate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MANGLYCtex"]}, "metabolites": {"manglyc_e": -1.0, "manglyc_p": 1.0}, "id": "MANGLYCtex", "gene_reaction_rule": "b0241 or b0929 or b1377 or b2215"}, {"subsystem": "Alternate Carbon Metabolism", "name": "2-O-alpha-mannosyl-6-phosphate-D-glycerate hydrolase", "upper_bound": 1000.0, 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0.0, "notes": {"original_bigg_ids": ["MLTG5"]}, "metabolites": {"glc__D_c": 1.0, "malthx_c": 1.0, "h2o_c": -1.0, "malthp_c": -1.0}, "id": "MLTG5", "gene_reaction_rule": "b0403"}, {"subsystem": "Murein Recycling", "name": "Murein lytic transglycosylase (murein4p4p) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MLTGY1pp"]}, "metabolites": {"murein4p4p_p": -1.0, "anhgm4p_p": 2.0}, "id": "MLTGY1pp", "gene_reaction_rule": "b2558 or b2963 or b4392 or b2813 or b2701 or b1193"}, {"subsystem": "Murein Recycling", "name": "Murein lytic transglycosylase (murein4p3p) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MLTGY2pp"]}, "metabolites": {"murein4p3p_p": -1.0, "anhgm3p_p": 1.0, "anhgm4p_p": 1.0}, "id": "MLTGY2pp", "gene_reaction_rule": "b1193 or b2558 or b2963 or b4392 or b2813 or b2701"}, {"subsystem": "Murein Recycling", "name": "Murein lytic transglycosylase (murein3p3p) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MLTGY3pp"]}, "metabolites": {"murein3p3p_p": -1.0, "anhgm3p_p": 2.0}, "id": "MLTGY3pp", "gene_reaction_rule": "b1193 or b2963 or b2558 or b4392 or b2813 or b2701"}, {"subsystem": "Murein Recycling", "name": "Murein lytic transglycosylase (murein4px4p4p) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MLTGY4pp"]}, "metabolites": {"murein4px4p_p": 1.0, "murein4px4p4p_p": -1.0, "anhgm4p_p": 1.0}, "id": "MLTGY4pp", "gene_reaction_rule": "b2701 or b1193 or b2963 or b2558 or b4392 or b2813"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Maltodextrin phosphorylase (maltopentaose)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MLTP1"]}, "metabolites": {"maltpt_c": -1.0, "pi_c": -1.0, "g1p_c": 1.0, "maltttr_c": 1.0}, "id": "MLTP1", "gene_reaction_rule": "b3417"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Maltodextrin phosphorylase (maltohexaose)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MLTP2"]}, "metabolites": {"maltpt_c": 1.0, "pi_c": -1.0, "malthx_c": -1.0, "g1p_c": 1.0}, "id": "MLTP2", "gene_reaction_rule": "b3417"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Maltodextrin phosphorylase (maltoheptaose)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MLTP3"]}, "metabolites": {"malthx_c": 1.0, "pi_c": -1.0, "malthp_c": -1.0, "g1p_c": 1.0}, "id": "MLTP3", "gene_reaction_rule": "b3417"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Methylmalonyl-CoA decarboxylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MMCD"]}, "metabolites": {"mmcoa__S_c": -1.0, "co2_c": 1.0, "h_c": -1.0, "ppcoa_c": 1.0}, "id": "MMCD", "gene_reaction_rule": "b2919"}, {"subsystem": "Transport, Inner Membrane", "name": "S-methylmethionine permease (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MMETt2pp"]}, "metabolites": {"mmet_p": -1.0, "h_c": 1.0, "h_p": -1.0, "mmet_c": 1.0}, "id": "MMETt2pp", "gene_reaction_rule": "b0260"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "S-methyl-L-methionine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MMETtex"]}, "metabolites": {"mmet_e": -1.0, "mmet_p": 1.0}, "id": "MMETtex", "gene_reaction_rule": "b0241 or b0929 or b1377 or b2215"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Methylmalonyl-CoA mutase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MMM"]}, "metabolites": {"mmcoa__S_c": 1.0, "succoa_c": -1.0}, "id": "MMM", "gene_reaction_rule": "b2917"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Manganese (Mn+2) transport out via proton antiport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MN2t3pp"]}, "metabolites": {"mn2_p": 1.0, "mn2_c": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "MN2t3pp", "gene_reaction_rule": "b3915 or b0752"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Manganese transport in via permease (no H+)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MN2tpp"]}, "metabolites": {"mn2_p": -1.0, "mn2_c": 1.0}, "id": "MN2tpp", "gene_reaction_rule": "b3040"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Mannose 6-phosphate phosphatase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MN6PP"]}, "metabolites": {"h2o_c": -1.0, "man6p_c": -1.0, "pi_c": 1.0, "man_c": 1.0}, "id": "MN6PP", "gene_reaction_rule": "b0822"}, {"subsystem": "Transport, Inner Membrane", "name": "Mannitol transport via PEP:Pyr PTS (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MNLptspp"]}, "metabolites": {"pep_c": -1.0, "pyr_c": 1.0, "mnl_p": -1.0, "mnl1p_c": 1.0}, "id": "MNLptspp", "gene_reaction_rule": "b3599 and b2415 and b2416"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Mannitol transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MNLtex"]}, "metabolites": {"mnl_p": 1.0, "mnl_e": -1.0}, "id": "MNLtex", "gene_reaction_rule": "b0241 or b0929 or b1377 or b2215"}, {"subsystem": "Alternate Carbon Metabolism", "name": "D-mannonate hydrolyase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MNNH"]}, "metabolites": {"h2o_c": 1.0, "2ddglcn_c": 1.0, "mana_c": -1.0}, "id": "MNNH", "gene_reaction_rule": "b4322"}, {"subsystem": "Transport, Inner Membrane", "name": "Manganese (Mn+2) transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MNt2pp"]}, "metabolites": {"mn2_p": -1.0, "mn2_c": 1.0, "h_c": 1.0, "h_p": -1.0}, "id": "MNt2pp", "gene_reaction_rule": "b2392"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Manganese (Mn+2) transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MNtex"]}, "metabolites": {"mn2_p": 1.0, "mn2_e": -1.0}, "id": "MNtex", "gene_reaction_rule": "b0241 or b0929 or b1377 or b2215"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "MoaD sulfuration (nadh, assumed)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MOADSUx"]}, "metabolites": {"iscssh_c": -1.0, "moadcosh_c": 1.0, "iscs_c": 1.0, "moadamp_c": -1.0, "amp_c": 1.0, "nad_c": 1.0, "nadh_c": -1.0}, "id": "MOADSUx", "gene_reaction_rule": "b2530 and b0784"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "3-deoxy-D-manno-octulosonic acid transferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MOAT"]}, "metabolites": {"h_c": 1.0, "ckdo_c": -1.0, "cmp_c": 1.0, "kdolipid4_c": 1.0, "lipidA_c": -1.0}, "id": "MOAT", "gene_reaction_rule": "b3633"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "3-deoxy-D-manno-octulosonic acid transferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MOAT2"]}, "metabolites": {"kdo2lipid4_c": 1.0, "ckdo_c": -1.0, "cmp_c": 1.0, "h_c": 1.0, "kdolipid4_c": -1.0}, "id": "MOAT2", "gene_reaction_rule": "b3633"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "3-deoxy-D-manno-octulosonic acid transferase III (LPS core biosynthesis)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MOAT3C"]}, "metabolites": {"ckdo_c": -1.0, "cmp_c": 1.0, "h_c": 1.0, "phphhlipa_c": -1.0, "kphphhlipa_c": 1.0}, "id": "MOAT3C", "gene_reaction_rule": "b3624"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Molybdate transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MOBDabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "mobd_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "mobd_p": -1.0}, "id": "MOBDabcpp", "gene_reaction_rule": "(b0763 and b0764 and b0765) or (b2422 and b2424 and b2423 and b3917) or (b2422 and b2425 and b2424 and b2423)"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Molybdate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MOBDtex"]}, "metabolites": {"mobd_e": -1.0, "mobd_p": 1.0}, "id": "MOBDtex", "gene_reaction_rule": "b0241 or b0929 or b1377 or b2215"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Molybdopterin cytidine dinucleotide synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MOCDS"]}, "metabolites": {"ctp_c": -1.0, "ppi_c": 1.0, "mococdp_c": 1.0, "moco_c": -1.0, "h_c": -1.0}, "id": "MOCDS", "gene_reaction_rule": "b2877"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Molybdenum cofactor synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MOCOS"]}, "metabolites": {"cu2_c": 1.0, "h2o_c": 1.0, "mobd_c": -1.0, "moco_c": 1.0, "h_c": -2.0, "mptamp_c": -1.0, "amp_c": 1.0}, "id": "MOCOS", "gene_reaction_rule": "b0827"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Molybdopterin guanine dinucleotide synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MOGDS"]}, "metabolites": {"mocogdp_c": 1.0, "ppi_c": 1.0, "gtp_c": -1.0, "h_c": -1.0, "moco_c": -1.0}, "id": "MOGDS", "gene_reaction_rule": "b3857 or (b3857 and b3856)"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "3-methyl-2-oxobutanoate hydroxymethyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MOHMT"]}, "metabolites": {"h2o_c": -1.0, "2dhp_c": 1.0, "thf_c": 1.0, "mlthf_c": -1.0, "3mob_c": -1.0}, "id": "MOHMT", "gene_reaction_rule": "b0134"}, {"subsystem": "Citric Acid Cycle", "name": "Malate oxidase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MOX"]}, "metabolites": {"h2o2_c": 1.0, "mal__L_c": -1.0, "oaa_c": 1.0, "o2_c": -1.0}, "id": "MOX", "gene_reaction_rule": ""}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Molybdopterin adenylyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MPTAT"]}, "metabolites": {"h_c": -1.0, "ppi_c": 1.0, "mpt_c": -1.0, "atp_c": -1.0, "mptamp_c": 1.0}, "id": "MPTAT", "gene_reaction_rule": "b0009"}, {"subsystem": "Murein Biosynthesis", "name": "Murein polymerizing transglycosylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MPTG"]}, "metabolites": {"udcpdp_c": 2.0, "uaagmda_c": -2.0, "h_c": 2.0, "murein5p5p_p": 1.0}, "id": "MPTG", "gene_reaction_rule": "(b3396 and b1069) or (b0149 and b1069) or (b1069 and b2519)"}, {"subsystem": "Murein Biosynthesis", "name": "Murein polymerizing transglycosylase 2 (three linked units)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MPTG2"]}, "metabolites": {"udcpdp_c": 1.0, "murein5p5p_p": -1.0, "murein5p5p5p_p": 1.0, "h_c": 1.0, "uaagmda_c": -1.0}, "id": "MPTG2", "gene_reaction_rule": "(b3396 and b1069) or (b0149 and b1069) or (b1069 and b2519)"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Molybdopterin synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MPTS"]}, "metabolites": {"cu2_c": -1.0, "mpt_c": 1.0, "moadcosh_c": -2.0, "cpmp_c": -1.0, "h_c": 5.0, "moadcoo_c": 2.0}, "id": "MPTS", "gene_reaction_rule": "b0784 and b0785"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Molybdopterin synthase sulfurylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MPTSS"]}, "metabolites": {"moadamp_c": 1.0, "ppi_c": 1.0, "h_c": -1.0, "atp_c": -1.0, "moadcoo_c": -1.0}, "id": "MPTSS", "gene_reaction_rule": "b0826"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Malonic semialdehyde reductase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MSAR"]}, "metabolites": {"3hpp_c": 1.0, "nadp_c": 1.0, "nadph_c": -1.0, "h_c": -1.0, "msa_c": -1.0}, "id": "MSAR", "gene_reaction_rule": "b1008 or b1539"}, {"subsystem": "Transport, Inner Membrane", "name": "Methanesulfonate transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MSO3abcpp"]}, "metabolites": {"h2o_c": -1.0, "mso3_c": 1.0, "atp_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "mso3_p": -1.0}, "id": "MSO3abcpp", "gene_reaction_rule": "b0936 and b0933 and b0934"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Methanesulfonate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MSO3tex"]}, "metabolites": {"mso3_e": -1.0, "mso3_p": 1.0}, "id": "MSO3tex", "gene_reaction_rule": "b0241 or b0929 or b1377 or b2215"}, {"subsystem": "Arginine and Proline Metabolism", "name": "Methylthioadenosine nucleosidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MTAN"]}, "metabolites": {"ade_c": 1.0, "h2o_c": -1.0, "5mta_c": -1.0, "5mtr_c": 1.0}, "id": "MTAN", "gene_reaction_rule": "b0159"}, {"subsystem": "Folate Metabolism", "name": "Methenyltetrahydrofolate cyclohydrolase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MTHFC"]}, "metabolites": {"h_c": 1.0, "h2o_c": -1.0, "10fthf_c": 1.0, "methf_c": -1.0}, "id": "MTHFC", "gene_reaction_rule": "b0529"}, {"subsystem": "Folate Metabolism", "name": "Methylenetetrahydrofolate dehydrogenase (NADP)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MTHFD"]}, "metabolites": {"nadp_c": -1.0, "nadph_c": 1.0, "methf_c": 1.0, "mlthf_c": -1.0}, "id": "MTHFD", "gene_reaction_rule": "b0529"}, {"subsystem": "Folate Metabolism", "name": "5,10-methylenetetrahydrofolate reductase (NADH)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MTHFR2"]}, "metabolites": {"mlthf_c": -1.0, "nadh_c": -1.0, "5mthf_c": 1.0, "nad_c": 1.0, "h_c": -2.0}, "id": "MTHFR2", "gene_reaction_rule": "b3941"}, {"subsystem": "Methionine Metabolism", "name": "(2R,4S)-2-methyl-2,3,3,4-tetrahydroxytetrahydrofuran synthesis (spontaneous)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MTHTHFSs"]}, "metabolites": {"h2o_c": -1.0, "mdhdhf_c": -1.0, "mththf_c": 1.0}, "id": "MTHTHFSs", "gene_reaction_rule": "s0001"}, {"subsystem": "Glycine and Serine Metabolism", "name": "N-methyltryptophan oxidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MTRPOX"]}, "metabolites": {"o2_c": -1.0, "h2o_c": -1.0, "Nmtrp_c": -1.0, "fald_c": 1.0, "h2o2_c": 1.0, "trp__L_c": 1.0}, "id": "MTRPOX", "gene_reaction_rule": "b1059"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Nitrious oxide transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["N2Otex"]}, "metabolites": {"n2o_p": 1.0, "n2o_e": -1.0}, "id": "N2Otex", "gene_reaction_rule": "b0241 or b0929 or b1377 or b2215"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Nitrious oxide transport (diffusion)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["N2Otpp"]}, "metabolites": {"n2o_c": 1.0, "n2o_p": -1.0}, "id": "N2Otpp", "gene_reaction_rule": "s0001"}, {"subsystem": "Arginine and Proline Metabolism", "name": "N-acetylornithine deacetylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NACODA"]}, "metabolites": {"glu5sa_c": 1.0, "ac_c": 1.0, "h2o_c": -1.0, "acg5sa_c": -1.0}, "id": "NACODA", "gene_reaction_rule": "b3957"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Nicotinic acid transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["NACtex"]}, "metabolites": {"nac_e": -1.0, "nac_p": 1.0}, "id": "NACtex", "gene_reaction_rule": "b0241 or b0929 or b1377 or b2215"}, {"subsystem": "Transport, Inner Membrane", "name": "Nicotinic acid uptake (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NACtpp"]}, "metabolites": {"nac_c": 1.0, "nac_p": -1.0}, "id": "NACtpp", "gene_reaction_rule": ""}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "NAD diphosphatase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADDP"]}, "metabolites": {"h2o_c": -1.0, "nmn_c": 1.0, "amp_c": 1.0, "nad_c": -1.0, "h_c": 2.0}, "id": "NADDP", "gene_reaction_rule": "b3996 or b2411"}, {"subsystem": "Oxidative Phosphorylation", "name": "NADH dehydrogenase (menaquinone-8 & 0 protons)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADH10"]}, "metabolites": {"nadh_c": -1.0, "mqn8_c": -1.0, "mql8_c": 1.0, "nad_c": 1.0, "h_c": -1.0}, "id": "NADH10", "gene_reaction_rule": "b1109"}, {"subsystem": "Oxidative Phosphorylation", "name": "NADH dehydrogenase (ubiquinone-8 & 3 protons) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADH16pp"]}, "metabolites": {"h_p": 3.0, "q8h2_c": 1.0, "h_c": -4.0, "nad_c": 1.0, "nadh_c": -1.0, "q8_c": -1.0}, "id": "NADH16pp", "gene_reaction_rule": "b2276 and b2277 and b2278 and b2279 and b2280 and b2281 and b2282 and b2283 and b2284 and b2285 and b2286 and b2287 and b2288"}, {"subsystem": "Oxidative Phosphorylation", "name": "NADH dehydrogenase (menaquinone-8 & 3 protons) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADH17pp"]}, "metabolites": {"mqn8_c": -1.0, "h_p": 3.0, "h_c": -4.0, "nad_c": 1.0, "nadh_c": -1.0, "mql8_c": 1.0}, "id": "NADH17pp", "gene_reaction_rule": "b2276 and b2277 and b2278 and b2279 and b2280 and b2281 and b2282 and b2283 and b2284 and b2285 and b2286 and b2287 and b2288"}, {"subsystem": "Oxidative Phosphorylation", "name": "NADH dehydrogenase (demethylmenaquinone-8 & 3 protons) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADH18pp"]}, "metabolites": {"2dmmq8_c": -1.0, "h_p": 3.0, "2dmmql8_c": 1.0, "h_c": -4.0, "nad_c": 1.0, "nadh_c": -1.0}, "id": "NADH18pp", "gene_reaction_rule": "b2276 and b2277 and b2278 and b2279 and b2280 and b2281 and b2282 and b2283 and b2284 and b2285 and b2286 and b2287 and b2288"}, {"subsystem": "Oxidative Phosphorylation", "name": "NADH dehydrogenase (ubiquinone-8 )", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADH5"]}, "metabolites": {"q8h2_c": 1.0, "nadh_c": -1.0, "h_c": -1.0, "nad_c": 1.0, "q8_c": -1.0}, "id": "NADH5", "gene_reaction_rule": "b1109"}, {"subsystem": "Oxidative Phosphorylation", "name": "NADH dehydrogenase (demethylmenaquinone-8 & 0 protons)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADH9"]}, "metabolites": {"h_c": -1.0, "nadh_c": -1.0, "nad_c": 1.0, "2dmmql8_c": 1.0, "2dmmq8_c": -1.0}, "id": "NADH9", "gene_reaction_rule": "b1109"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "NAD kinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADK"]}, "metabolites": {"nad_c": -1.0, "nadp_c": 1.0, "h_c": 1.0, "atp_c": -1.0, "adp_c": 1.0}, "id": "NADK", "gene_reaction_rule": "b2615"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "NAD nucleosidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADN"]}, "metabolites": {"h2o_c": -1.0, "nad_c": -1.0, "h_c": 1.0, "adprib_c": 1.0, "ncam_c": 1.0}, "id": "NADN", "gene_reaction_rule": ""}, {"subsystem": "Oxidative Phosphorylation", "name": "NADPH Quinone Reductase (Ubiquinone-8)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADPHQR2"]}, "metabolites": {"q8h2_c": 1.0, "nadp_c": 1.0, "nadph_c": -1.0, "h_c": -1.0, "q8_c": -1.0}, "id": "NADPHQR2", "gene_reaction_rule": "b3028"}, {"subsystem": "Oxidative Phosphorylation", "name": "NADPH Quinone Reductase (Menaquinone-8)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADPHQR3"]}, "metabolites": {"nadph_c": -1.0, "nadp_c": 1.0, "mqn8_c": -1.0, "h_c": -1.0, "mql8_c": 1.0}, "id": "NADPHQR3", "gene_reaction_rule": "b3028"}, {"subsystem": "Oxidative Phosphorylation", "name": "NADPH Quinone Reductase (2-Demethylmenaquinone-8)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADPHQR4"]}, "metabolites": {"nadp_c": 1.0, "nadph_c": -1.0, "h_c": -1.0, "2dmmql8_c": 1.0, "2dmmq8_c": -1.0}, "id": "NADPHQR4", "gene_reaction_rule": "b3028"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "NADP phosphatase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADPPPS"]}, "metabolites": {"h2o_c": -1.0, "nadp_c": -1.0, "pi_c": 1.0, "nad_c": 1.0}, "id": "NADPPPS", "gene_reaction_rule": ""}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "NAD synthase (nh3)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADS1"]}, "metabolites": {"dnad_c": -1.0, "atp_c": -1.0, "ppi_c": 1.0, "h_c": 1.0, "nad_c": 1.0, "nh4_c": -1.0, "amp_c": 1.0}, "id": "NADS1", "gene_reaction_rule": "b1740"}, {"subsystem": "Oxidative Phosphorylation", "name": "NAD transhydrogenase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADTRHD"]}, "metabolites": {"nadph_c": -1.0, "nadh_c": 1.0, "nadp_c": 1.0, "nad_c": -1.0}, "id": "NADTRHD", "gene_reaction_rule": "b3962 or (b1602 and b1603)"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Nicotinic acid mononucleotide pyrophosphorylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NAMNPP"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "nicrnt_c": 1.0, "ppi_c": 1.0, "nac_c": -1.0, "adp_c": 1.0, "pi_c": 1.0, "prpp_c": -1.0}, "id": "NAMNPP", "gene_reaction_rule": "b0931"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Sodium proton antiporter (H:NA is 1.5) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NAt3_1p5pp"]}, "metabolites": {"na1_p": 2.0, "na1_c": -2.0, "h_c": 3.0, "h_p": -3.0}, "id": "NAt3_1p5pp", "gene_reaction_rule": "b1186"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Sodium proton antiporter (H:NA is 2) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NAt3_2pp"]}, "metabolites": {"na1_p": 1.0, "na1_c": -1.0, "h_c": 2.0, "h_p": -2.0}, "id": "NAt3_2pp", "gene_reaction_rule": "b0019"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Sodium transport out via proton antiport (cytoplasm to periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NAt3pp"]}, "metabolites": {"na1_p": 1.0, "na1_c": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "NAt3pp", "gene_reaction_rule": "b0842 or b1216"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Sodium transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["NAtex"]}, "metabolites": {"na1_p": 1.0, "na1_e": -1.0}, "id": "NAtex", "gene_reaction_rule": "b0241 or b0929 or b1377 or b2215"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Nucleoside-diphosphate kinase (ATP:GDP)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["NDPK1"]}, "metabolites": {"gdp_c": -1.0, "gtp_c": 1.0, "atp_c": -1.0, "adp_c": 1.0}, "id": "NDPK1", "gene_reaction_rule": "b0474 or b2518"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Nucleoside-diphosphate kinase (ATP:UDP)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["NDPK2"]}, "metabolites": {"utp_c": 1.0, "udp_c": -1.0, "atp_c": -1.0, "adp_c": 1.0}, "id": "NDPK2", "gene_reaction_rule": "b0474 or b2518"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Nucleoside-diphosphate kinase (ATP:CDP)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["NDPK3"]}, "metabolites": {"ctp_c": 1.0, "cdp_c": -1.0, "adp_c": 1.0, "atp_c": -1.0}, "id": "NDPK3", "gene_reaction_rule": "b2518 or b0474"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Nucleoside-diphosphate kinase (ATP:dTDP)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["NDPK4"]}, "metabolites": {"dttp_c": 1.0, "dtdp_c": -1.0, "adp_c": 1.0, "atp_c": -1.0}, "id": "NDPK4", "gene_reaction_rule": "b0474 or b2518"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Nucleoside-diphosphate kinase (ATP:dGDP)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["NDPK5"]}, "metabolites": {"dgdp_c": -1.0, "dgtp_c": 1.0, "atp_c": -1.0, "adp_c": 1.0}, "id": "NDPK5", "gene_reaction_rule": "b0474 or b2518"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Nucleoside-diphosphate kinase (ATP:dUDP)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["NDPK6"]}, "metabolites": {"adp_c": 1.0, "dutp_c": 1.0, "atp_c": -1.0, "dudp_c": -1.0}, "id": "NDPK6", "gene_reaction_rule": "b2518 or b0474"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Nucleoside-diphosphate kinase (ATP:dCDP)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["NDPK7"]}, "metabolites": {"dctp_c": 1.0, "adp_c": 1.0, "atp_c": -1.0, "dcdp_c": -1.0}, "id": "NDPK7", "gene_reaction_rule": "b0474 or b2518"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Nucleoside-diphosphate kinase (ATP:dADP)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": 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1.0, "h_c": -1.0, "nad_c": 1.0, "no_c": -2.0, "n2o_c": 1.0, "nadh_c": -1.0}, "id": "NHFRBO", "gene_reaction_rule": "b2710 and b2711"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Nickle (Ni+2) ABC transporter (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NI2abcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "ni2_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "ni2_p": 1.0}, "id": "NI2abcpp", "gene_reaction_rule": "b3469"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Nickle (Ni+2) transport out via proton antiport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NI2t3pp"]}, "metabolites": {"ni2_c": -1.0, "h_c": 1.0, "h_p": -1.0, "ni2_p": 1.0}, "id": "NI2t3pp", "gene_reaction_rule": "b3915 or b0752"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Nickel transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["NI2tex"]}, "metabolites": {"ni2_e": -1.0, "ni2_p": 1.0}, "id": "NI2tex", "gene_reaction_rule": "b0241 or b0929 or b1377 or b2215"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Nickel (+2) transport in via permease (no H+)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NI2tpp"]}, "metabolites": {"ni2_c": 1.0, "ni2_p": -1.0}, "id": "NI2tpp", "gene_reaction_rule": "b3816"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Nickel transport via ABC system (uptake, periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NI2uabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "ni2_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "ni2_p": -1.0}, "id": "NI2uabcpp", "gene_reaction_rule": "(b3476 and b3477 and b3478 and b3479 and b3480) or b4242"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Nicotinamide-nucleotide 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-1.0, "26dap__M_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "uamag_c": -1.0, "ugmd_c": 1.0}, "id": "UAAGDS", "gene_reaction_rule": "b0085"}, {"subsystem": "Alternate Carbon Metabolism", "name": "UDP-N-acetyl-D-galactosamine pyrophosphohydrolase (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["UACGALPpp"]}, "metabolites": {"h2o_p": -1.0, "ump_p": 1.0, "acgal1p_p": 1.0, "udpacgal_p": -1.0, "h_p": 2.0}, "id": "UACGALPpp", "gene_reaction_rule": "b0480"}, {"subsystem": "Alternate Carbon Metabolism", "name": "UDP-N-acetyl-D-glucosamine pyrophosphohydrolase (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["UACGAMPpp"]}, "metabolites": {"h2o_p": -1.0, "ump_p": 1.0, "uacgam_p": -1.0, "h_p": 2.0, "acgam1p_p": 1.0}, "id": "UACGAMPpp", "gene_reaction_rule": "b0480"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "UDP-N-acetyl-D-glucosamine transport via diffusion (extracellular to periplasm)", 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-1000.0, "notes": {"original_bigg_ids": ["UAGAAT"]}, "metabolites": {"uacgam_c": -1.0, "u3aga_c": 1.0, "ACP_c": 1.0, "3hmrsACP_c": -1.0}, "id": "UAGAAT", "gene_reaction_rule": "b1094 and b0181"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "UDP-N-acetylglucosamine 1-carboxyvinyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["UAGCVT"]}, "metabolites": {"uacgam_c": -1.0, "pep_c": -1.0, "uaccg_c": 1.0, "pi_c": 1.0}, "id": "UAGCVT", "gene_reaction_rule": "b3189"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "UDP-N-acetylglucosamine diphosphorylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["UAGDP"]}, "metabolites": {"uacgam_c": 1.0, "ppi_c": 1.0, "utp_c": -1.0, "h_c": -1.0, "acgam1p_c": -1.0}, "id": "UAGDP", "gene_reaction_rule": "b3730"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "UDP-N-acetylglucosamine-N-acetylmuramyl-(pentapeptide)pyrophosphoryl-undecaprenol N-acetylglucosamine 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"Undecaprenyl-diphosphatase (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["UDCPDPpp"]}, "metabolites": {"pi_p": 1.0, "h2o_p": -1.0, "udcpdp_p": -1.0, "udcpp_p": 1.0, "h_p": 1.0}, "id": "UDCPDPpp", "gene_reaction_rule": "b1278 or b3057 or b0841"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "Undecaprenyl phosphate transport (cytoplasm to periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["UDCPPtppi"]}, "metabolites": {"udcpp_p": -1.0, "udcpp_c": 1.0}, "id": "UDCPPtppi", "gene_reaction_rule": ""}, {"subsystem": "Transport, Outer Membrane Porin", "name": "UDP-N-acetyl-D-galactosamine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["UDPACGALtex"]}, "metabolites": {"udpacgal_e": -1.0, "udpacgal_p": 1.0}, "id": "UDPACGALtex", "gene_reaction_rule": "b0241 or b0929 or b1377 or b2215"}, {"subsystem": "Alternate Carbon Metabolism", "name": "UDPglucose 4-epimerase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["UDPG4E"]}, "metabolites": {"udpgal_c": 1.0, "udpg_c": -1.0}, "id": "UDPG4E", "gene_reaction_rule": "b0759"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "UDPgalactopyranose mutase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["UDPGALM"]}, "metabolites": {"udpgal_c": -1.0, "udpgalfur_c": 1.0}, "id": "UDPGALM", "gene_reaction_rule": "b2036"}, {"subsystem": "Alternate Carbon Metabolism", "name": "UDPgalactose pyrophosphohydrolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["UDPGALPpp"]}, "metabolites": {"h2o_p": -1.0, "udpgal_p": -1.0, "gal1p_p": 1.0, "h_p": 2.0, "ump_p": 1.0}, "id": "UDPGALPpp", "gene_reaction_rule": "b0480"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "UDPgalactose transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, 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"UDP-4''-ketopentose:UDP-4-amino-4-deoxy-L-arabinose aminotransferase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["UDPKAAT"]}, "metabolites": {"akg_c": 1.0, "glu__L_c": -1.0, "udpLa4o_c": -1.0, "udpLa4n_c": 1.0}, "id": "UDPKAAT", "gene_reaction_rule": "b2253"}, {"subsystem": "Alternate Carbon Metabolism", "name": "UDP-D-glucuronate pyrophosphohydrolase (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["UGLCURPpp"]}, "metabolites": {"h2o_p": -1.0, "glcur1p_p": 1.0, "ump_p": 1.0, "h_p": 2.0, "udpglcur_p": -1.0}, "id": "UGLCURPpp", "gene_reaction_rule": "b0480"}, {"subsystem": "Alternate Carbon Metabolism", "name": "UDPglucose--hexose-1-phosphate uridylyltransferase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["UGLT"]}, "metabolites": {"udpgal_c": 1.0, "udpg_c": -1.0, "gal1p_c": -1.0, "g1p_c": 1.0}, "id": "UGLT", "gene_reaction_rule": "b0758"}, {"subsystem": "Nitrogen 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{"original_bigg_ids": ["b2223"]}, "name": "atoE", "id": "b2223"}, {"notes": {"original_bigg_ids": ["b0351"]}, "name": "mhpF", "id": "b0351"}, {"notes": {"original_bigg_ids": ["b1241"]}, "name": "adhE", "id": "b1241"}, {"notes": {"original_bigg_ids": ["s0001"]}, "name": "None", "id": "s0001"}, {"notes": {"original_bigg_ids": ["b1463"]}, "name": "nhoA", "id": "b1463"}, {"notes": {"original_bigg_ids": ["b1993"]}, "name": "cobU", "id": "b1993"}, {"notes": {"original_bigg_ids": ["b2316"]}, "name": "accD", "id": "b2316"}, {"notes": {"original_bigg_ids": ["b3256"]}, "name": "accC", "id": "b3256"}, {"notes": {"original_bigg_ids": ["b0185"]}, "name": "accA", "id": "b0185"}, {"notes": {"original_bigg_ids": ["b3255"]}, "name": "accB", "id": "b3255"}, {"notes": {"original_bigg_ids": ["b4069"]}, "name": "acs", "id": "b4069"}, {"notes": {"original_bigg_ids": ["b1119"]}, "name": "nagK", "id": "b1119"}, {"notes": {"original_bigg_ids": ["b3784"]}, "name": "wecA", "id": "b3784"}, {"notes": {"original_bigg_ids": ["b2417"]}, "name": "crr", "id": "b2417"}, {"notes": {"original_bigg_ids": ["b2416"]}, "name": "ptsI", "id": "b2416"}, {"notes": {"original_bigg_ids": ["b1101"]}, "name": "ptsG", "id": "b1101"}, {"notes": {"original_bigg_ids": ["b0679"]}, "name": "nagE", "id": "b0679"}, {"notes": {"original_bigg_ids": ["b2415"]}, "name": "ptsH", "id": "b2415"}, {"notes": {"original_bigg_ids": ["b3959"]}, "name": "argB", "id": "b3959"}, {"notes": {"original_bigg_ids": ["b2818"]}, "name": "argA", "id": "b2818"}, {"notes": {"original_bigg_ids": ["b3670"]}, "name": "ilvN", "id": "b3670"}, {"notes": {"original_bigg_ids": ["b3671"]}, "name": "ilvB", "id": "b3671"}, {"notes": {"original_bigg_ids": ["b0077"]}, "name": "ilvI", "id": "b0077"}, {"notes": {"original_bigg_ids": ["b0078"]}, "name": "ilvH", "id": "b0078"}, {"notes": {"original_bigg_ids": ["b3115"]}, "name": "tdcD", "id": "b3115"}, {"notes": {"original_bigg_ids": ["b2296"]}, "name": "ackA", "id": "b2296"}, {"notes": {"original_bigg_ids": ["b1849"]}, "name": "purT", "id": "b1849"}, {"notes": {"original_bigg_ids": ["b2428"]}, "name": "murQ", "id": "b2428"}, {"notes": {"original_bigg_ids": ["b3794"]}, "name": "wecG", "id": "b3794"}, {"notes": {"original_bigg_ids": ["b1818"]}, "name": "manY", "id": "b1818"}, {"notes": {"original_bigg_ids": ["b1819"]}, "name": "manZ", "id": "b1819"}, {"notes": {"original_bigg_ids": ["b1817"]}, "name": "manX", "id": "b1817"}, {"notes": {"original_bigg_ids": ["b2429"]}, "name": "murP", "id": "b2429"}, {"notes": {"original_bigg_ids": ["b3224"]}, "name": "nanT", "id": "b3224"}, {"notes": {"original_bigg_ids": ["b4311"]}, "name": "nanC", "id": "b4311"}, {"notes": {"original_bigg_ids": ["b3225"]}, "name": "nanA", "id": "b3225"}, {"notes": {"original_bigg_ids": ["b0221"]}, "name": "fadE", "id": "b0221"}, {"notes": {"original_bigg_ids": ["b1091"]}, "name": "fabH", "id": "b1091"}, {"notes": {"original_bigg_ids": ["b3957"]}, "name": "argE", "id": "b3957"}, {"notes": {"original_bigg_ids": ["b3201"]}, "name": "lptB", "id": "b3201"}, {"notes": {"original_bigg_ids": ["b3199"]}, "name": "lptC", "id": "b3199"}, {"notes": {"original_bigg_ids": ["b4262"]}, "name": "lptG", "id": "b4262"}, {"notes": {"original_bigg_ids": ["b3200"]}, "name": "lptA", "id": "b3200"}, {"notes": {"original_bigg_ids": ["b4261"]}, "name": "lptF", "id": "b4261"}, {"notes": {"original_bigg_ids": ["b1519"]}, "name": "tam", "id": "b1519"}, {"notes": {"original_bigg_ids": ["b0118"]}, "name": "acnB", "id": "b0118"}, {"notes": {"original_bigg_ids": ["b1276"]}, "name": "acnA", "id": "b1276"}, {"notes": {"original_bigg_ids": ["b1748"]}, "name": "astC", "id": "b1748"}, {"notes": {"original_bigg_ids": ["b3359"]}, "name": "argD", "id": "b3359"}, {"notes": {"original_bigg_ids": ["b1090"]}, "name": "plsX", "id": "b1090"}, {"notes": {"original_bigg_ids": ["b3475"]}, "name": "acpT", "id": "b3475"}, {"notes": {"original_bigg_ids": ["b2563"]}, "name": "acpS", "id": "b2563"}, {"notes": {"original_bigg_ids": ["b1533"]}, "name": "eamA", "id": "b1533"}, {"notes": {"original_bigg_ids": ["b2578"]}, "name": "eamB", "id": "b2578"}, {"notes": {"original_bigg_ids": ["b4067"]}, "name": "actP", "id": "b4067"}, {"notes": {"original_bigg_ids": ["b1623"]}, "name": "add", "id": "b1623"}, {"notes": {"original_bigg_ids": ["b1096"]}, "name": "pabC", "id": "b1096"}, {"notes": {"original_bigg_ids": ["b3360"]}, "name": "pabA", "id": "b3360"}, {"notes": {"original_bigg_ids": ["b1812"]}, "name": "pabB", "id": "b1812"}, {"notes": {"original_bigg_ids": ["b3665"]}, "name": "adeD", "id": "b3665"}, {"notes": {"original_bigg_ids": ["b3654"]}, "name": "xanP", "id": "b3654"}, {"notes": {"original_bigg_ids": ["b3714"]}, "name": "adeP", "id": "b3714"}, {"notes": {"original_bigg_ids": ["b0474"]}, "name": "adk", "id": "b0474"}, {"notes": {"original_bigg_ids": ["b0120"]}, "name": "speD", "id": "b0120"}, {"notes": {"original_bigg_ids": ["b3806"]}, "name": "cyaA", "id": "b3806"}, {"notes": {"original_bigg_ids": ["b0030"]}, "name": "rihC", "id": "b0030"}, {"notes": {"original_bigg_ids": ["b2393"]}, "name": "nupC", "id": "b2393"}, {"notes": {"original_bigg_ids": ["b2964"]}, "name": "nupG", "id": "b2964"}, {"notes": {"original_bigg_ids": ["b2406"]}, "name": "xapB", "id": "b2406"}, {"notes": {"original_bigg_ids": ["b0411"]}, "name": "tsx", "id": "b0411"}, {"notes": {"original_bigg_ids": ["b1992"]}, "name": "cobS", "id": "b1992"}, {"notes": {"original_bigg_ids": ["b1711"]}, "name": "btuC", "id": "b1711"}, {"notes": {"original_bigg_ids": ["b1709"]}, "name": "btuD", "id": "b1709"}, {"notes": {"original_bigg_ids": ["b0158"]}, "name": "btuF", "id": "b0158"}, {"notes": {"original_bigg_ids": ["b3006"]}, "name": "exbB", "id": "b3006"}, {"notes": {"original_bigg_ids": ["b3966"]}, "name": "btuB", "id": "b3966"}, {"notes": {"original_bigg_ids": ["b1252"]}, "name": "tonB", "id": "b1252"}, {"notes": {"original_bigg_ids": ["b3005"]}, "name": "exbD", "id": "b3005"}, {"notes": 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{"original_bigg_ids": ["b0511"]}, "name": "ybbW", "id": "b0511"}, {"notes": {"original_bigg_ids": ["b4085"]}, "name": "alsE", "id": "b4085"}, {"notes": {"original_bigg_ids": ["b4088"]}, "name": "alsB", "id": "b4088"}, {"notes": {"original_bigg_ids": ["b4087"]}, "name": "alsA", "id": "b4087"}, {"notes": {"original_bigg_ids": ["b4086"]}, "name": "alsC", "id": "b4086"}, {"notes": {"original_bigg_ids": ["b1677"]}, "name": "lpp", "id": "b1677"}, {"notes": {"original_bigg_ids": ["b0657"]}, "name": "lnt", "id": "b0657"}, {"notes": {"original_bigg_ids": ["b1781"]}, "name": "yeaE", "id": "b1781"}, {"notes": {"original_bigg_ids": ["b3012"]}, "name": "dkgA", "id": "b3012"}, {"notes": {"original_bigg_ids": ["b0207"]}, "name": "dkgB", "id": "b0207"}, {"notes": {"original_bigg_ids": ["b3001"]}, "name": "gpr", "id": "b3001"}, {"notes": {"original_bigg_ids": ["b3945"]}, "name": "gldA", "id": "b3945"}, {"notes": {"original_bigg_ids": ["b3091"]}, "name": "uxaA", "id": "b3091"}, {"notes": {"original_bigg_ids": ["b3416"]}, "name": "malQ", "id": "b3416"}, {"notes": {"original_bigg_ids": ["b3223"]}, "name": "nanE", "id": "b3223"}, {"notes": {"original_bigg_ids": ["b3222"]}, "name": "nanK", "id": "b3222"}, {"notes": {"original_bigg_ids": ["b0774"]}, "name": "bioA", "id": "b0774"}, {"notes": {"original_bigg_ids": ["b3833"]}, "name": "ubiE", "id": "b3833"}, {"notes": {"original_bigg_ids": ["b3994"]}, "name": "thiC", "id": "b3994"}, {"notes": {"original_bigg_ids": ["b1982"]}, "name": "amn", "id": "b1982"}, {"notes": {"original_bigg_ids": ["b4260"]}, "name": "pepA", "id": "b4260"}, {"notes": {"original_bigg_ids": ["b0932"]}, "name": "pepN", "id": "b0932"}, {"notes": {"original_bigg_ids": ["b2523"]}, "name": "pepB", "id": "b2523"}, {"notes": {"original_bigg_ids": ["b0237"]}, "name": "pepD", "id": "b0237"}, {"notes": {"original_bigg_ids": ["b1640"]}, "name": "anmK", "id": "b1640"}, {"notes": {"original_bigg_ids": ["b1263"]}, "name": "trpD", "id": "b1263"}, {"notes": 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"moadcosh_c"}, {"name": "Molybdate", "notes": {"original_bigg_ids": ["mobd_c"]}, "charge": -2, "formula": "MoO4", "compartment": "c", "id": "mobd_c"}, {"name": "Molybdenum cofactor", "notes": {"original_bigg_ids": ["moco_c"]}, "charge": -2, "formula": "C10H10N5O8PS2Mo", "compartment": "c", "id": "moco_c"}, {"name": "Molybdopterin cytosine dinucleotide", "notes": {"original_bigg_ids": ["mococdp_c"]}, "charge": -2, "formula": "C19H22N8O15P2S2Mo", "compartment": "c", "id": "mococdp_c"}, {"name": "Molybdopterin guanine dinucleotide", "notes": {"original_bigg_ids": ["mocogdp_c"]}, "charge": -2, "formula": "C20H22N10O15P2S2Mo", "compartment": "c", "id": "mocogdp_c"}, {"name": "Molybdopterin", "notes": {"original_bigg_ids": ["mpt_c"]}, "charge": -2, "formula": "C10H10N5O6PS2Cu", "compartment": "c", "id": "mpt_c"}, {"name": "Adenylated molybdopterin", "notes": {"original_bigg_ids": ["mptamp_c"]}, "charge": -2, "formula": "C20H22N10O12P2S2Cu", "compartment": "c", "id": "mptamp_c"}, {"name": 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["nicrnt_c"]}, "charge": -2, "formula": "C11H12NO9P", "compartment": "c", "id": "nicrnt_c"}, {"name": "NMN", "notes": {"original_bigg_ids": ["nmn_c"]}, "charge": -1, "formula": "C11H14N2O8P", "compartment": "c", "id": "nmn_c"}, {"name": "Nitric oxide", "notes": {"original_bigg_ids": ["no_c"]}, "charge": 0, "formula": "NO", "compartment": "c", "id": "no_c"}, {"name": "Nitrite", "notes": {"original_bigg_ids": ["no2_c"]}, "charge": -1, "formula": "NO2", "compartment": "c", "id": "no2_c"}, {"name": "Nitrate", "notes": {"original_bigg_ids": ["no3_c"]}, "charge": -1, "formula": "NO3", "compartment": "c", "id": "no3_c"}, {"name": "O16 antigen undecaprenyl diphosphate", "notes": {"original_bigg_ids": ["o16aund_c"]}, "charge": -2, "formula": "C89H145N1O32P2", "compartment": "c", "id": "o16aund_c"}, {"name": "O2", "notes": {"original_bigg_ids": ["o2_c"]}, "charge": 0, "formula": "O2", "compartment": "c", "id": "o2_c"}, {"name": "Superoxide anion", "notes": {"original_bigg_ids": ["o2s_c"]}, 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"id": "ocdcaACP_c"}, {"name": "Octadecanoyl-phosphate (n-C18:0)", "notes": {"original_bigg_ids": ["ocdcap_c"]}, "charge": -1, "formula": "C18H36O5P", "compartment": "c", "id": "ocdcap_c"}, {"name": "Octadecenoate (n-C18:1)", "notes": {"original_bigg_ids": ["ocdcea_c"]}, "charge": -1, "formula": "C18H33O2", "compartment": "c", "id": "ocdcea_c"}, {"name": "Octadecanoyl-phosphate (n-C18:1)", "notes": {"original_bigg_ids": ["ocdceap_c"]}, "charge": -1, "formula": "C18H34O5P", "compartment": "c", "id": "ocdceap_c"}, {"name": "Octanoate (n-C8:0)", "notes": {"original_bigg_ids": ["octa_c"]}, "charge": -1, "formula": "C8H15O2", "compartment": "c", "id": "octa_c"}, {"name": "Octanoate (protein bound)", "notes": {"original_bigg_ids": ["octapb_c"]}, "charge": 1, "formula": "C8H15O", "compartment": "c", "id": "octapb_c"}, {"name": "All-trans-Octaprenyl diphosphate", "notes": {"original_bigg_ids": ["octdp_c"]}, "charge": -3, "formula": "C40H65O7P2", "compartment": "c", "id": "octdp_c"}, {"name": 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"compartment": "c", "id": "op4en_c"}, {"name": "3-Oxo-pimeloyl-[acyl-carrier protein] methyl ester", "notes": {"original_bigg_ids": ["opmeACP_c"]}, "charge": -1, "formula": "C19H31N2O11PRS", "compartment": "c", "id": "opmeACP_c"}, {"name": "Ornithine", "notes": {"original_bigg_ids": ["orn_c"]}, "charge": 1, "formula": "C5H13N2O2", "compartment": "c", "id": "orn_c"}, {"name": "Orotate", "notes": {"original_bigg_ids": ["orot_c"]}, "charge": -1, "formula": "C5H3N2O4", "compartment": "c", "id": "orot_c"}, {"name": "Orotidine 5'-phosphate", "notes": {"original_bigg_ids": ["orot5p_c"]}, "charge": -3, "formula": "C10H10N2O11P", "compartment": "c", "id": "orot5p_c"}, {"name": "Oxalate", "notes": {"original_bigg_ids": ["oxa_c"]}, "charge": -2, "formula": "C2O4", "compartment": "c", "id": "oxa_c"}, {"name": "3-Oxoadipyl-CoA", "notes": {"original_bigg_ids": ["oxadpcoa_c"]}, "charge": -5, "formula": "C27H37N7O20P3S", "compartment": "c", "id": "oxadpcoa_c"}, {"name": "Oxalyl-CoA", "notes": 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"id": "unaga_c"}, {"name": "Undecaprenyl-diphospho-N-acetylglucosamine-N-acetylmannosaminuronate", "notes": {"original_bigg_ids": ["unagamu_c"]}, "charge": -3, "formula": "C71H113N2O18P2", "compartment": "c", "id": "unagamu_c"}, {"name": "Undecaprenyl-diphospho N-acetylglucosamine-N-acetylmannosaminuronate-N-acetamido-4,6-dideoxy-D-galactose", "notes": {"original_bigg_ids": ["unagamuf_c"]}, "charge": -3, "formula": "C79H126N3O22P2", "compartment": "c", "id": "unagamuf_c"}, {"name": "Uroporphyrinogen III", "notes": {"original_bigg_ids": ["uppg3_c"]}, "charge": -8, "formula": "C40H36N4O16", "compartment": "c", "id": "uppg3_c"}, {"name": "Uracil", "notes": {"original_bigg_ids": ["ura_c"]}, "charge": 0, "formula": "C4H4N2O2", "compartment": "c", "id": "ura_c"}, {"name": "Ureidoacrylate peracid", "notes": {"original_bigg_ids": ["uracp_c"]}, "charge": 0, "formula": "C4H6N2O4", "compartment": "c", "id": "uracp_c"}, {"name": "Urate", "notes": {"original_bigg_ids": ["urate_c"]}, "charge": 0, 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"12ppd__S_e"}, {"name": "1,4-alpha-D-glucan", "notes": {"original_bigg_ids": ["14glucan_e"]}, "charge": 0, "formula": "C36H62O31", "compartment": "e", "id": "14glucan_e"}, {"name": "1,5-Diaminopentane", "notes": {"original_bigg_ids": ["15dap_e"]}, "charge": 2, "formula": "C5H16N2", "compartment": "e", "id": "15dap_e"}, {"name": "2,3-diaminopropionate", "notes": {"original_bigg_ids": ["23dappa_e"]}, "charge": 1, "formula": "C3H9N2O2", "compartment": "e", "id": "23dappa_e"}, {"name": "Meso-2,6-Diaminoheptanedioate", "notes": {"original_bigg_ids": ["26dap_DASH_M_e"]}, "charge": 0, "formula": "C7H14N2O4", "compartment": "e", "id": "26dap__M_e"}, {"name": "2-Dehydro-3-deoxy-D-gluconate", "notes": {"original_bigg_ids": ["2ddglcn_e"]}, "charge": -1, "formula": "C6H9O6", "compartment": "e", "id": "2ddglcn_e"}, {"name": "3-hydroxycinnamic acid", "notes": {"original_bigg_ids": ["3hcinnm_e"]}, "charge": -1, "formula": "C9H7O3", "compartment": "e", "id": "3hcinnm_e"}, {"name": "3-Hydroxypropanoate", "notes": {"original_bigg_ids": ["3hpp_e"]}, "charge": -1, "formula": "C3H5O3", "compartment": "e", "id": "3hpp_e"}, {"name": "3-(3-hydroxy-phenyl)propionate", "notes": {"original_bigg_ids": ["3hpppn_e"]}, "charge": -1, "formula": "C9H9O3", "compartment": "e", "id": "3hpppn_e"}, {"name": "4-Aminobutanoate", "notes": {"original_bigg_ids": ["4abut_e"]}, "charge": 0, "formula": "C4H9NO2", "compartment": "e", "id": "4abut_e"}, {"name": "5-Dehydro-D-gluconate", "notes": {"original_bigg_ids": ["5dglcn_e"]}, "charge": -1, "formula": "C6H9O7", "compartment": "e", "id": "5dglcn_e"}, {"name": "5-Methylthio-D-ribose", "notes": {"original_bigg_ids": ["5mtr_e"]}, "charge": 0, "formula": "C6H12O4S", "compartment": "e", "id": "5mtr_e"}, {"name": "L-alanine-D-glutamate", "notes": {"original_bigg_ids": ["LalaDglu_e"]}, "charge": -1, "formula": "C8H13N2O5", "compartment": "e", "id": "LalaDglu_e"}, {"name": "L-alanine-D-glutamate-meso-2,6-diaminoheptanedioate", "notes": 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"notes": {"original_bigg_ids": ["na1_e"]}, "charge": 1, "formula": "Na", "compartment": "e", "id": "na1_e"}, {"name": "Nicotinate", "notes": {"original_bigg_ids": ["nac_e"]}, "charge": -1, "formula": "C6H4NO2", "compartment": "e", "id": "nac_e"}, {"name": "Ammonium", "notes": {"original_bigg_ids": ["nh4_e"]}, "charge": 1, "formula": "H4N", "compartment": "e", "id": "nh4_e"}, {"name": "Nickel", "notes": {"original_bigg_ids": ["ni2_e"]}, "charge": 2, "formula": "Ni", "compartment": "e", "id": "ni2_e"}, {"name": "NMN", "notes": {"original_bigg_ids": ["nmn_e"]}, "charge": -1, "formula": "C11H14N2O8P", "compartment": "e", "id": "nmn_e"}, {"name": "Nitric oxide", "notes": {"original_bigg_ids": ["no_e"]}, "charge": 0, "formula": "NO", "compartment": "e", "id": "no_e"}, {"name": "Nitrite", "notes": {"original_bigg_ids": ["no2_e"]}, "charge": -1, "formula": "NO2", "compartment": "e", "id": "no2_e"}, {"name": "Nitrate", "notes": {"original_bigg_ids": ["no3_e"]}, "charge": -1, "formula": "NO3", "compartment": "e", "id": "no3_e"}, {"name": "O2", "notes": {"original_bigg_ids": ["o2_e"]}, "charge": 0, "formula": "O2", "compartment": "e", "id": "o2_e"}, {"name": "Superoxide anion", "notes": {"original_bigg_ids": ["o2s_e"]}, "charge": -1, "formula": "O2", "compartment": "e", "id": "o2s_e"}, {"name": "Octadecanoate (n-C18:0)", "notes": {"original_bigg_ids": ["ocdca_e"]}, "charge": -1, "formula": "C18H35O2", "compartment": "e", "id": "ocdca_e"}, {"name": "Octadecenoate (n-C18:1)", "notes": {"original_bigg_ids": ["ocdcea_e"]}, "charge": -1, "formula": "C18H33O2", "compartment": "e", "id": "ocdcea_e"}, {"name": "Octanoate (n-C8:0)", "notes": {"original_bigg_ids": ["octa_e"]}, "charge": -1, "formula": "C8H15O2", "compartment": "e", "id": "octa_e"}, {"name": "Ornithine", "notes": {"original_bigg_ids": ["orn_e"]}, "charge": 1, "formula": "C5H13N2O2", "compartment": "e", "id": "orn_e"}, {"name": "Orotate", "notes": {"original_bigg_ids": ["orot_e"]}, "charge": -1, "formula": "C5H3N2O4", "compartment": "e", "id": "orot_e"}, {"name": "Phenylacetaldehyde", "notes": {"original_bigg_ids": ["pacald_e"]}, "charge": 0, "formula": "C8H8O", "compartment": "e", "id": "pacald_e"}, {"name": "L-Phenylalanine", "notes": {"original_bigg_ids": ["phe_DASH_L_e"]}, "charge": 0, "formula": "C9H11NO2", "compartment": "e", "id": "phe__L_e"}, {"name": "Protoheme", "notes": {"original_bigg_ids": ["pheme_e"]}, "charge": -2, "formula": "C34H30FeN4O4", "compartment": "e", "id": "pheme_e"}, {"name": "Phosphate", "notes": {"original_bigg_ids": ["pi_e"]}, "charge": -2, "formula": "HO4P", "compartment": "e", "id": "pi_e"}, {"name": "(R)-Pantothenate", "notes": {"original_bigg_ids": ["pnto_DASH_R_e"]}, "charge": -1, "formula": "C9H16NO5", "compartment": "e", "id": "pnto__R_e"}, {"name": "Propionate (n-C3:0)", "notes": {"original_bigg_ids": ["ppa_e"]}, "charge": -1, "formula": "C3H5O2", "compartment": "e", "id": "ppa_e"}, {"name": "Propanal", "notes": {"original_bigg_ids": ["ppal_e"]}, "charge": 0, 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0, "formula": "C11H12Cl2N2O5", "compartment": "e", "id": "cm_e"}, {"name": "Core oligosaccharide lipid A diphosphate", "notes": {"original_bigg_ids": ["colipap_e"]}, "charge": -12, "formula": "C176H303N2O103P5", "compartment": "e", "id": "colipap_e"}, {"name": "Dopamine", "notes": {"original_bigg_ids": ["dopa_e"]}, "charge": 1, "formula": "C8H12NO2", "compartment": "e", "id": "dopa_e"}, {"name": "Doxorubicin", "notes": {"original_bigg_ids": ["doxrbcn_e"]}, "charge": 0, "formula": "C27H29NO11", "compartment": "e", "id": "doxrbcn_e"}, {"name": "(enterobacterial common antigen)x4 core oligosaccharide lipid A", "notes": {"original_bigg_ids": ["eca4colipa_e"]}, "charge": -15, "formula": "C272H447N14O160P4", "compartment": "e", "id": "eca4colipa_e"}, {"name": "Phosphoethanolamine KDO(2)-lipid (A)", "notes": {"original_bigg_ids": ["enlipa_e"]}, "charge": -6, "formula": "C112H202N3O42P3", "compartment": "e", "id": "enlipa_e"}, {"name": "Fe(III)dicitrate", "notes": {"original_bigg_ids": ["fe3dcit_e"]}, "charge": -3, "formula": "C12H10FeO14", "compartment": "e", "id": "fe3dcit_e"}, {"name": "Fusidic acid", "notes": {"original_bigg_ids": ["fusa_e"]}, "charge": 0, "formula": "C31H48O5", "compartment": "e", "id": "fusa_e"}, {"name": "Beta D-Galactose", "notes": {"original_bigg_ids": ["gal_DASH_bD_e"]}, "charge": 0, "formula": "C6H12O6", "compartment": "e", "id": "gal_bD_e"}, {"name": "Galactitol", "notes": {"original_bigg_ids": ["galt_e"]}, "charge": 0, "formula": "C6H14O6", "compartment": "e", "id": "galt_e"}, {"name": "D-Glucosamine", "notes": {"original_bigg_ids": ["gam_e"]}, "charge": 1, "formula": "C6H14NO5", "compartment": "e", "id": "gam_e"}, {"name": "D-Glucuronate 1-phosphate", "notes": {"original_bigg_ids": ["glcur1p_e"]}, "charge": -3, "formula": "C6H8O10P", "compartment": "e", "id": "glcur1p_e"}, {"name": "Hepta-acylated core oligosaccharide lipid A (E. coli)", "notes": {"original_bigg_ids": ["hacolipa_e"]}, "charge": -11, "formula": "C192H333N2O101P4", "compartment": "e", "id": "hacolipa_e"}, {"name": "Hepta-acylated KDO(2)-lipid (A)", "notes": {"original_bigg_ids": ["halipa_e"]}, "charge": -6, "formula": "C126H226N2O40P2", "compartment": "e", "id": "halipa_e"}, {"name": "2(alpha-D-Mannosyl)-D-glycerate", "notes": {"original_bigg_ids": ["manglyc_e"]}, "charge": -1, "formula": "C9H15O9", "compartment": "e", "id": "manglyc_e"}, {"name": "Minocycline", "notes": {"original_bigg_ids": ["mincyc_e"]}, "charge": 0, "formula": "C23H27N3O7", "compartment": "e", "id": "mincyc_e"}, {"name": "Myo-Inositol hexakisphosphate", "notes": {"original_bigg_ids": ["minohp_e"]}, "charge": -12, "formula": "C6H6O24P6", "compartment": "e", "id": "minohp_e"}, {"name": "D-Mannitol", "notes": {"original_bigg_ids": ["mnl_e"]}, "charge": 0, "formula": "C6H14O6", "compartment": "e", "id": "mnl_e"}, {"name": "Novobiocin", "notes": {"original_bigg_ids": ["novbcn_e"]}, "charge": 0, "formula": "C31H36N2O11", "compartment": "e", "id": "novbcn_e"}, {"name": "(O16 antigen)x4 core oligosaccharide lipid A", "notes": {"original_bigg_ids": ["o16a4colipa_e"]}, "charge": -11, "formula": "C312H523N6O200P4", "compartment": "e", "id": "o16a4colipa_e"}, {"name": "Phenethylamine", "notes": {"original_bigg_ids": ["peamn_e"]}, "charge": 1, "formula": "C8H12N", "compartment": "e", "id": "peamn_e"}, {"name": "Phosphonate", "notes": {"original_bigg_ids": ["ppt_e"]}, "charge": -2, "formula": "HO3P", "compartment": "e", "id": "ppt_e"}, {"name": "Rifampin", "notes": {"original_bigg_ids": ["rfamp_e"]}, "charge": 0, "formula": "C43H58N4O12", "compartment": "e", "id": "rfamp_e"}, {"name": "D-Sorbitol", "notes": {"original_bigg_ids": ["sbt_DASH_D_e"]}, "charge": 0, "formula": "C6H14O6", "compartment": "e", "id": "sbt__D_e"}, {"name": "Sucrose", "notes": {"original_bigg_ids": ["sucr_e"]}, "charge": 0, "formula": "C12H22O11", "compartment": "e", "id": "sucr_e"}, {"name": "L-Threonine O-3-phosphate", "notes": {"original_bigg_ids": ["thrp_e"]}, "charge": -2, "formula": "C4H8NO6P", "compartment": "e", "id": "thrp_e"}, {"name": "Tetracycline", "notes": {"original_bigg_ids": ["ttrcyc_e"]}, "charge": 0, "formula": "C22H24N2O8", "compartment": "e", "id": "ttrcyc_e"}, {"name": "Tyramine", "notes": {"original_bigg_ids": ["tym_e"]}, "charge": 1, "formula": "C8H12NO", "compartment": "e", "id": "tym_e"}, {"name": "Phosphotyrosine", "notes": {"original_bigg_ids": ["tyrp_e"]}, "charge": -2, "formula": "C9H10NO6P", "compartment": "e", "id": "tyrp_e"}, {"name": "UDP-N-acetyl-D-galactosamine", "notes": {"original_bigg_ids": ["udpacgal_e"]}, "charge": -2, "formula": "C17H25N3O17P2", "compartment": "e", "id": "udpacgal_e"}, {"name": "1,2-Diacyl-sn-glycerol (didodecanoyl, n-C12:0)", "notes": {"original_bigg_ids": ["12dgr120_p"]}, "charge": 0, "formula": "C27H52O5", "compartment": "p", "id": "12dgr120_p"}, {"name": "1,2-Diacyl-sn-glycerol (ditetradecanoyl, n-C14:0)", "notes": {"original_bigg_ids": ["12dgr140_p"]}, "charge": 0, "formula": "C31H60O5", "compartment": "p", "id": "12dgr140_p"}, {"name": "1,2-Diacyl-sn-glycerol (ditetradec-7-enoyl, n-C14:1)", "notes": {"original_bigg_ids": ["12dgr141_p"]}, "charge": 0, "formula": "C31H56O5", "compartment": "p", "id": "12dgr141_p"}, {"name": "1,2-Diacyl-sn-glycerol (dihexadecanoyl, n-C16:0)", "notes": {"original_bigg_ids": ["12dgr160_p"]}, "charge": 0, "formula": "C35H68O5", "compartment": "p", "id": "12dgr160_p"}, {"name": "1,2-Diacyl-sn-glycerol (dihexadec-9-enoyl, n-C16:1)", "notes": {"original_bigg_ids": ["12dgr161_p"]}, "charge": 0, "formula": "C35H64O5", "compartment": "p", "id": "12dgr161_p"}, {"name": "1,2-Diacyl-sn-glycerol (dioctadecanoyl, n-C18:0)", "notes": {"original_bigg_ids": ["12dgr180_p"]}, "charge": 0, "formula": "C39H76O5", "compartment": "p", "id": "12dgr180_p"}, {"name": "1,2-Diacyl-sn-glycerol (dioctadec-11-enoyl, n-C18:1)", "notes": {"original_bigg_ids": ["12dgr181_p"]}, "charge": 0, "formula": "C39H72O5", "compartment": "p", "id": "12dgr181_p"}, {"name": "(R)-Propane-1,2-diol", "notes": {"original_bigg_ids": ["12ppd_DASH_R_p"]}, "charge": 0, "formula": "C3H8O2", "compartment": "p", "id": "12ppd__R_p"}, {"name": "(S)-Propane-1,2-diol", "notes": {"original_bigg_ids": ["12ppd_DASH_S_p"]}, "charge": 0, "formula": "C3H8O2", "compartment": "p", "id": "12ppd__S_p"}, {"name": "1,4-alpha-D-glucan", "notes": {"original_bigg_ids": ["14glucan_p"]}, "charge": 0, "formula": "C36H62O31", "compartment": "p", "id": "14glucan_p"}, {"name": "1,5-Diaminopentane", "notes": {"original_bigg_ids": ["15dap_p"]}, "charge": 2, "formula": "C5H16N2", "compartment": "p", "id": "15dap_p"}, {"name": "1-dodecanoyl-sn-glycerol 3-phosphate", "notes": {"original_bigg_ids": ["1ddecg3p_p"]}, "charge": -2, "formula": "C15H29O7P1", "compartment": "p", "id": "1ddecg3p_p"}, {"name": "1-hexadec-9-enoyl-sn-glycerol 3-phosphate", "notes": {"original_bigg_ids": ["1hdec9eg3p_p"]}, "charge": -2, "formula": "C19H35O7P1", "compartment": "p", "id": "1hdec9eg3p_p"}, {"name": "1-hexadecanoyl-sn-glycerol 3-phosphate", "notes": {"original_bigg_ids": ["1hdecg3p_p"]}, "charge": -2, "formula": "C19H37O7P1", "compartment": "p", "id": "1hdecg3p_p"}, {"name": "1-octadec-11-enoyl-sn-glycerol 3-phosphate", "notes": {"original_bigg_ids": ["1odec11eg3p_p"]}, "charge": -2, "formula": "C21H39O7P1", "compartment": "p", "id": "1odec11eg3p_p"}, {"name": "1-octadecanoyl-sn-glycerol 3-phosphate", "notes": {"original_bigg_ids": ["1odecg3p_p"]}, "charge": -2, "formula": "C21H41O7P1", "compartment": "p", "id": "1odecg3p_p"}, {"name": "1-tetradec-7-enoyl-sn-glycerol 3-phosphate", "notes": {"original_bigg_ids": ["1tdec7eg3p_p"]}, "charge": -2, "formula": "C17H31O7P1", "compartment": "p", "id": "1tdec7eg3p_p"}, {"name": "1-tetradecanoyl-sn-glycerol 3-phosphate", "notes": {"original_bigg_ids": ["1tdecg3p_p"]}, "charge": -2, "formula": "C17H33O7P1", "compartment": "p", "id": "1tdecg3p_p"}, {"name": "2,3-diaminopropionate", "notes": {"original_bigg_ids": ["23dappa_p"]}, "charge": 1, "formula": "C3H9N2O2", "compartment": "p", "id": "23dappa_p"}, {"name": "Meso-2,6-Diaminoheptanedioate", "notes": {"original_bigg_ids": ["26dap_DASH_M_p"]}, "charge": 0, "formula": "C7H14N2O4", "compartment": "p", "id": "26dap__M_p"}, {"name": "2-Acyl-sn-glycero-3-phosphoethanolamine (n-C12:0)", "notes": {"original_bigg_ids": ["2agpe120_p"]}, "charge": 0, "formula": "C17H36NO7P1", "compartment": "p", "id": "2agpe120_p"}, {"name": "2-Acyl-sn-glycero-3-phosphoethanolamine (n-C14:0)", "notes": {"original_bigg_ids": ["2agpe140_p"]}, "charge": 0, "formula": "C19H40NO7P1", "compartment": "p", "id": "2agpe140_p"}, {"name": "2-Acyl-sn-glycero-3-phosphoethanolamine (n-C14:1)", "notes": {"original_bigg_ids": ["2agpe141_p"]}, "charge": 0, "formula": "C19H38NO7P1", "compartment": "p", "id": "2agpe141_p"}, {"name": "2-Acyl-sn-glycero-3-phosphoethanolamine (n-C16:0)", "notes": {"original_bigg_ids": ["2agpe160_p"]}, "charge": 0, "formula": "C21H44NO7P1", "compartment": "p", "id": "2agpe160_p"}, {"name": "2-Acyl-sn-glycero-3-phosphoethanolamine (n-C16:1)", "notes": {"original_bigg_ids": ["2agpe161_p"]}, "charge": 0, "formula": "C21H42NO7P1", "compartment": "p", "id": "2agpe161_p"}, {"name": "2-Acyl-sn-glycero-3-phosphoethanolamine (n-C18:0)", "notes": {"original_bigg_ids": ["2agpe180_p"]}, "charge": 0, "formula": "C23H48NO7P1", "compartment": "p", "id": "2agpe180_p"}, {"name": "2-Acyl-sn-glycero-3-phosphoethanolamine (n-C18:1)", "notes": {"original_bigg_ids": ["2agpe181_p"]}, "charge": 0, "formula": "C23H46NO7P1", "compartment": "p", "id": "2agpe181_p"}, {"name": "2-Acyl-sn-glycero-3-phosphoglycerol (n-C12:0)", "notes": {"original_bigg_ids": ["2agpg120_p"]}, "charge": -1, "formula": "C18H36O9P1", "compartment": "p", "id": "2agpg120_p"}, {"name": "2-Acyl-sn-glycero-3-phosphoglycerol (n-C14:0)", "notes": {"original_bigg_ids": ["2agpg140_p"]}, "charge": -1, "formula": "C20H40O9P1", "compartment": "p", "id": "2agpg140_p"}, {"name": "2-Acyl-sn-glycero-3-phosphoglycerol (n-C14:1)", "notes": {"original_bigg_ids": ["2agpg141_p"]}, "charge": -1, "formula": "C20H38O9P1", "compartment": "p", "id": "2agpg141_p"}, {"name": "2-Acyl-sn-glycero-3-phosphoglycerol (n-C16:0)", "notes": {"original_bigg_ids": ["2agpg160_p"]}, "charge": -1, "formula": "C22H44O9P1", "compartment": "p", "id": "2agpg160_p"}, {"name": "2-Acyl-sn-glycero-3-phosphoglycerol (n-C16:1)", "notes": {"original_bigg_ids": ["2agpg161_p"]}, "charge": -1, "formula": "C22H42O9P1", "compartment": "p", "id": "2agpg161_p"}, {"name": "2-Acyl-sn-glycero-3-phosphoglycerol (n-C18:0)", "notes": {"original_bigg_ids": ["2agpg180_p"]}, "charge": -1, "formula": "C24H48O9P1", "compartment": "p", "id": "2agpg180_p"}, {"name": "2-Acyl-sn-glycero-3-phosphoglycerol (n-C18:1)", "notes": {"original_bigg_ids": ["2agpg181_p"]}, "charge": -1, "formula": "C24H46O9P1", "compartment": "p", "id": "2agpg181_p"}, {"name": "2-dodecanoyl-sn-glycerol 3-phosphate", "notes": {"original_bigg_ids": ["2ddecg3p_p"]}, "charge": -1, "formula": "C15H30O7P1", "compartment": "p", "id": "2ddecg3p_p"}, {"name": "2-Dehydro-3-deoxy-D-gluconate", "notes": {"original_bigg_ids": ["2ddglcn_p"]}, "charge": -1, "formula": "C6H9O6", "compartment": "p", "id": "2ddglcn_p"}, {"name": "2-hexadec-9-enoyl-sn-glycerol 3-phosphate", "notes": {"original_bigg_ids": ["2hdec9eg3p_p"]}, "charge": -1, "formula": "C19H36O7P1", "compartment": "p", "id": "2hdec9eg3p_p"}, {"name": "2-hexadecanoyl-sn-glycerol 3-phosphate", "notes": {"original_bigg_ids": ["2hdecg3p_p"]}, "charge": -1, "formula": "C19H38O7P1", "compartment": "p", "id": "2hdecg3p_p"}, {"name": "2-octadec-11-enoyl-sn-glycerol 3-phosphate", "notes": {"original_bigg_ids": ["2odec11eg3p_p"]}, "charge": -1, "formula": "C21H40O7P1", "compartment": "p", "id": "2odec11eg3p_p"}, {"name": "2-octadecanoyl-sn-glycerol 3-phosphate", "notes": {"original_bigg_ids": ["2odecg3p_p"]}, "charge": -1, "formula": "C21H42O7P1", "compartment": "p", "id": "2odecg3p_p"}, {"name": "2-tetradec-7-enoyl-sn-glycerol 3-phosphate", 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["5dglcn_p"]}, "charge": -1, "formula": "C6H9O7", "compartment": "p", "id": "5dglcn_p"}, {"name": "5-Methylthio-D-ribose", "notes": {"original_bigg_ids": ["5mtr_p"]}, "charge": 0, "formula": "C6H12O4S", "compartment": "p", "id": "5mtr_p"}, {"name": "L-alanine-D-glutamate", "notes": {"original_bigg_ids": ["LalaDglu_p"]}, "charge": -1, "formula": "C8H13N2O5", "compartment": "p", "id": "LalaDglu_p"}, {"name": "L-alanine-D-glutamate-meso-2,6-diaminoheptanedioate", "notes": {"original_bigg_ids": ["LalaDgluMdap_p"]}, "charge": -1, "formula": "C15H25N4O8", "compartment": "p", "id": "LalaDgluMdap_p"}, {"name": "L-alanine-D-glutamate-meso-2,6-diaminoheptanedioate-D-alanine", "notes": {"original_bigg_ids": ["LalaDgluMdapDala_p"]}, "charge": -1, "formula": "C18H30N5O9", "compartment": "p", "id": "LalaDgluMdapDala_p"}, {"name": "L-alanine-L-glutamate", "notes": {"original_bigg_ids": ["LalaLglu_p"]}, "charge": -1, "formula": "C8H13N2O5", "compartment": "p", "id": "LalaLglu_p"}, {"name": "Acetate", "notes": {"original_bigg_ids": ["ac_p"]}, "charge": -1, "formula": "C2H3O2", "compartment": "p", "id": "ac_p"}, {"name": "Acetoacetate", "notes": {"original_bigg_ids": ["acac_p"]}, "charge": -1, "formula": "C4H5O3", "compartment": "p", "id": "acac_p"}, {"name": "Acetaldehyde", "notes": {"original_bigg_ids": ["acald_p"]}, "charge": 0, "formula": "C2H4O", "compartment": "p", "id": "acald_p"}, {"name": "N-Acetyl-D-glucosamine", "notes": {"original_bigg_ids": ["acgam_p"]}, "charge": 0, "formula": "C8H15NO6", "compartment": "p", "id": "acgam_p"}, {"name": "N-Acetyl-D-glucosamine 1-phosphate", "notes": {"original_bigg_ids": ["acgam1p_p"]}, "charge": -2, "formula": "C8H14NO9P", "compartment": "p", "id": "acgam1p_p"}, {"name": "N-Acetyl-D-mannosamine", "notes": {"original_bigg_ids": ["acmana_p"]}, "charge": 0, "formula": "C8H15NO6", "compartment": "p", "id": "acmana_p"}, {"name": "N-Acetylneuraminate", "notes": {"original_bigg_ids": ["acnam_p"]}, "charge": -1, "formula": "C11H18NO9", 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+] +} +}, +{ +"id":"b1858", +"name":"znuC", +"notes":{ +"original_bigg_ids":[ +"b1858" +] +} +} +], +"id":"iJO1366", +"compartments":{ +"c":"cytosol", +"e":"extracellular space", +"p":"periplasm" +}, +"version":"1" +} \ No newline at end of file diff --git a/1-0-0/6/models/Homo sapiens/RECON1.json b/1-0-0/6/models/Homo sapiens/RECON1.json index 39f2be2f..4b641996 100644 --- a/1-0-0/6/models/Homo sapiens/RECON1.json +++ b/1-0-0/6/models/Homo sapiens/RECON1.json @@ -1 +1,122073 @@ -{"reactions": [{"subsystem": "Transport, Lysosomal", "name": "10FTHF5GLUtl", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["10FTHF5GLUtl"]}, "metabolites": {"10fthf5glu_c": -1.0, "10fthf5glu_l": 1.0}, "id": "10FTHF5GLUtl", "gene_reaction_rule": ""}, {"subsystem": "Transport, Mitochondrial", "name": "10FTHF5GLUtm", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["10FTHF5GLUtm"]}, "metabolites": {"10fthf5glu_c": 1.0, "10fthf5glu_m": -1.0}, "id": 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"upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["34DHPHAMT"]}, "metabolites": {"amet_c": -1.0, "homoval_c": 1.0, "h_c": 1.0, "ahcys_c": 1.0, "34dhpha_c": -1.0}, "id": "34DHPHAMT", "gene_reaction_rule": "1312_AT1 or 1312_AT2"}, {"subsystem": "Transport, Extracellular", "name": "34DHPHEt", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["34DHPHEt"]}, "metabolites": {"34dhphe_e": -1.0, "34dhphe_c": 1.0}, "id": "34DHPHEt", "gene_reaction_rule": "117247_AT1"}, {"subsystem": "Tyrosine metabolism", "name": "Aldehyde dehydrogenase 3 4 dihydroxyphenylacetaldehyde NAD ", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["34DHPLACOX"]}, "metabolites": {"h2o_c": -1.0, "34dhpac_c": -1.0, "34dhpha_c": 1.0, "h_c": 2.0, "nad_c": -1.0, "nadh_c": 1.0}, "id": "34DHALDD", "gene_reaction_rule": "221_AT1 or 222_AT1 or 218_AT1 or 220_AT1"}, {"subsystem": "Tyrosine metabolism", "name": "34DHPLACOX LPAREN NADP RPAREN ", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["34DHPLACOX_LPAREN_NADP_RPAREN_"]}, "metabolites": {"h2o_c": -1.0, "nadp_c": -1.0, "nadph_c": 1.0, "34dhpac_c": -1.0, "34dhpha_c": 1.0, "h_c": 2.0}, "id": "34DHPLACOX_NADP", "gene_reaction_rule": "222_AT1 or 221_AT1 or 218_AT1"}, {"subsystem": "Tyrosine metabolism", "name": "34DHXMANDACOX", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["34DHXMANDACOX"]}, "metabolites": {"h2o_c": -1.0, "34dhoxmand_c": 1.0, "34dhmald_c": -1.0, "h_c": 2.0, "nad_c": -1.0, "nadh_c": 1.0}, "id": "34DHXMANDACOX", "gene_reaction_rule": "221_AT1 or 218_AT1 or 220_AT1"}, {"subsystem": "Tyrosine metabolism", "name": "34DHXMANDACOX LPAREN NADP RPAREN ", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["34DHXMANDACOX_LPAREN_NADP_RPAREN_"]}, "metabolites": {"h2o_c": -1.0, "nadp_c": -1.0, "nadph_c": 1.0, "34dhoxmand_c": 1.0, "34dhmald_c": -1.0, "h_c": 2.0}, "id": "34DHXMANDACOX_NADP", "gene_reaction_rule": "221_AT1 or 222_AT1"}, {"subsystem": "Ubiquinone Biosynthesis", "name": "3 4 hydroxyphenyl lactate formation", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["34HPLFM"]}, "metabolites": {"34hpl_m": 1.0, "nad_m": 1.0, "h_m": -1.0, "34hpp_m": -1.0, "nadh_m": -1.0}, "id": "34HPLFM", "gene_reaction_rule": ""}, {"subsystem": "Tyrosine metabolism", "name": "4 Hydroxyphenylpyruvateoxygen oxidoreductase", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["34HPPOR"]}, "metabolites": {"o2_c": -1.0, "34hpp_c": -1.0, "co2_c": 1.0, "hgentis_c": 1.0}, "id": "34HPPOR", "gene_reaction_rule": "3242_AT1"}, {"subsystem": "Transport, Nuclear", "name": "35CGMPtn", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["35CGMPtn"]}, "metabolites": {"35cgmp_n": 1.0, "35cgmp_c": -1.0}, "id": "35CGMPtn", "gene_reaction_rule": ""}, {"subsystem": "Valine, Leucine, and Isoleucine 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{"subsystem": "Butanoate Metabolism", "name": "3HBCDm", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["3HBCDm"]}, "metabolites": {"h2o_m": -1.0, "3hbcoa__R_m": 1.0, "b2coa_m": -1.0}, "id": "3HBCDm", "gene_reaction_rule": "55268_AT1"}, {"subsystem": "Valine, Leucine, and Isoleucine Metabolism", "name": "3HBCOAHLm", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["3HBCOAHLm"]}, "metabolites": {"3hmp_m": 1.0, "3hibutcoa_m": -1.0, "coa_m": 1.0, "h_m": 1.0, "h2o_m": -1.0}, "id": "3HBCOAHLm", "gene_reaction_rule": ""}, {"subsystem": "Transport, Extracellular", "name": "3HCO3 NAt", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["3HCO3_NAt"]}, "metabolites": {"hco3_c": 3.0, "na1_c": 1.0, "na1_e": -1.0, "hco3_e": -3.0}, "id": "3HCO3_NAt", "gene_reaction_rule": "57835_AT3 or 8671_AT1 or 57835_AT2 or 57835_AT1 or 57835_AT4"}, {"subsystem": "Tryptophan metabolism", "name": "3HKYNAKGAT", 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"metabolites": {"3hpp_c": -1.0, "nadh_c": 1.0, "nad_c": -1.0, "msa_c": 1.0, "h_c": 1.0}, "id": "3HPPD", "gene_reaction_rule": ""}, {"subsystem": "Tryptophan metabolism", "name": "3HXKYNDCL", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["3HXKYNDCL"]}, "metabolites": {"3hxkynam_c": 1.0, "hLkynr_c": -1.0, "co2_c": 1.0, "h_c": -1.0}, "id": "3HXKYNDCL", "gene_reaction_rule": "1644_AT1"}, {"subsystem": "Tryptophan metabolism", "name": "3HXKYNOXDA", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["3HXKYNOXDA"]}, "metabolites": {"3hxkynam_c": -1.0, "o2_c": -1.0, "48dhoxquin_c": 1.0, "nh4_c": 1.0, "h2o2_c": 1.0}, "id": "3HXKYNOXDA", "gene_reaction_rule": "4128_AT1 or 4129_AT1"}, {"subsystem": "Tyrosine metabolism", "name": "3M4HDXPAC", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["3M4HDXPAC"]}, "metabolites": {"h2o_c": -1.0, "homoval_c": 1.0, "h_c": 2.0, "nad_c": -1.0, "nadh_c": 1.0, 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"id": "ABUTt4_2_r", "gene_reaction_rule": "6529_AT1 or 6538_AT1 or 6540_AT1 or 6539_AT1"}, {"subsystem": "Cholesterol Metabolism", "name": "Acetyl-CoA C-acetyltransferase", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ACACT1", "ACACT1r"]}, "metabolites": {"aacoa_c": 1.0, "coa_c": 1.0, "accoa_c": -2.0}, "id": "ACACT1r_copy1", "gene_reaction_rule": "39_AT1"}, {"subsystem": "Valine, Leucine, and Isoleucine Metabolism", "name": "ACACT10m", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["ACACT10m"]}, "metabolites": {"ppcoa_m": 1.0, "accoa_m": 1.0, "coa_m": -1.0, "2maacoa_m": -1.0}, "id": "ACACT10m", "gene_reaction_rule": "38_AT1"}, {"subsystem": "Tryptophan metabolism", "name": "Acetyl-CoA C-acetyltransferase", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["ACACT1", "ACACT1r"]}, "metabolites": {"aacoa_c": 1.0, "coa_c": 1.0, "accoa_c": -2.0}, "id": "ACACT1r_copy2", "gene_reaction_rule": 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374907_AT2 or 10678_AT2 or 10331_AT1"}, {"subsystem": "Keratan sulfate biosynthesis", "name": "AG13T17g", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AG13T17g"]}, "metabolites": {"h_g": 1.0, "uacgam_g": -1.0, "udp_g": 1.0, "ksii_core4_pre5_g": 1.0, "ksii_core4_pre4_g": -1.0}, "id": "AG13T17g", "gene_reaction_rule": "10678_AT2 or 11041_AT1 or 10678_AT1 or 374907_AT2 or 93010_AT1 or 374907_AT1 or 284208_AT1 or 79369_AT1 or 10331_AT1"}, {"subsystem": "Keratan sulfate biosynthesis", "name": "AG13T18g", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AG13T18g"]}, "metabolites": {"ksii_core4_pre7_g": -1.0, "h_g": 1.0, "ksii_core4_pre8_g": 1.0, "uacgam_g": -1.0, "udp_g": 1.0}, "id": "AG13T18g", "gene_reaction_rule": "10678_AT2 or 11041_AT1 or 10678_AT1 or 374907_AT2 or 93010_AT1 or 374907_AT1 or 284208_AT1 or 79369_AT1 or 10331_AT1"}, {"subsystem": "Keratan sulfate biosynthesis", "name": "AG13T1g", "upper_bound": 999999.0, 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"gene_reaction_rule": "1109_AT1"}, {"subsystem": "Bile Acid Biosynthesis", "name": "AKR1D", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AKR1D"]}, "metabolites": {"nadp_c": 1.0, "nadph_c": -1.0, "h_c": -1.0, "xol7ah_c": 1.0, "xol7aone_c": -1.0}, "id": "AKR1D", "gene_reaction_rule": "6718_AT1"}, {"subsystem": "Bile Acid Biosynthesis", "name": "AKR1D2", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AKR1D2"]}, "metabolites": {"xoldiolone_c": -1.0, "nadp_c": 1.0, "nadph_c": -1.0, "h_c": -1.0, "xoldioloneh_c": 1.0}, "id": "AKR1D2", "gene_reaction_rule": "6718_AT1"}, {"subsystem": "Transport, Extracellular", "name": "ALAASNNaEx", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALAASNNaEx"]}, "metabolites": {"asn__L_e": 1.0, "ala__L_e": -1.0, "na1_c": 1.0, "ala__L_c": 1.0, "na1_e": -1.0, "asn__L_c": -1.0}, "id": "ALAASNNaEx", "gene_reaction_rule": "6510_AT1"}, {"subsystem": "Transport, Extracellular", "name": "ALACYSNaEx", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALACYSNaEx"]}, "metabolites": {"cys__L_c": -1.0, "cys__L_e": 1.0, "ala__L_e": -1.0, "na1_c": 1.0, "ala__L_c": 1.0, "na1_e": -1.0}, "id": "ALACYSNaEx", "gene_reaction_rule": "6509_AT1 or 6510_AT1"}, {"subsystem": "Transport, Extracellular", "name": "ALADGLNexR", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["ALADGLNexR"]}, "metabolites": {"gln__L_e": 1.0, "ala__D_e": -1.0, "ala__D_c": 1.0, "gln__L_c": -1.0}, "id": "ALADGLNexR", "gene_reaction_rule": "56301_AT1 and 6520_AT1"}, {"subsystem": "Transport, Extracellular", "name": "ALADGLYexR", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["ALADGLYexR"]}, "metabolites": {"ala__D_e": -1.0, "gly_e": 1.0, "ala__D_c": 1.0, "gly_c": -1.0}, "id": "ALADGLYexR", "gene_reaction_rule": "56301_AT1 and 6520_AT1"}, {"subsystem": "Transport, Extracellular", "name": "ALAGLNNaEx", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALAGLNNaEx"]}, "metabolites": {"ala__L_e": -1.0, "na1_c": 1.0, "ala__L_c": 1.0, "na1_e": -1.0, "gln__L_e": 1.0, "gln__L_c": -1.0}, "id": "ALAGLNNaEx", "gene_reaction_rule": "6510_AT1"}, {"subsystem": "Transport, Extracellular", "name": "ALAGLNexR", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["ALAGLNexR"]}, "metabolites": {"gln__L_e": 1.0, "ala__L_e": -1.0, "ala__L_c": 1.0, "gln__L_c": -1.0}, "id": "ALAGLNexR", "gene_reaction_rule": "6520_AT1 and 56301_AT1"}, {"subsystem": "Transport, Extracellular", "name": "ALAGLYexR", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["ALAGLYexR"]}, "metabolites": {"ala__L_e": -1.0, "gly_e": 1.0, "ala__L_c": 1.0, "gly_c": -1.0}, "id": "ALAGLYexR", "gene_reaction_rule": "56301_AT1 and 6520_AT1"}, {"subsystem": "Alanine and Aspartate Metabolism", "name": "Alanine racemase", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["ALAR"]}, "metabolites": {"ala__L_c": -1.0, "ala__D_c": 1.0}, "id": "ALAR", "gene_reaction_rule": "11212_AT1"}, {"subsystem": "Transport, Extracellular", "name": "ALASERNaEx", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALASERNaEx"]}, "metabolites": {"ala__L_e": -1.0, "na1_c": 1.0, "ala__L_c": 1.0, "na1_e": -1.0, "ser__L_c": -1.0, "ser__L_e": 1.0}, "id": "ALASERNaEx", "gene_reaction_rule": "6509_AT1 or 6510_AT1"}, {"subsystem": "Glycine, Serine, and Threonine Metabolism", "name": "5 aminolevulinate synthase", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALASm"]}, "metabolites": {"succoa_m": -1.0, "gly_m": -1.0, "co2_m": 1.0, "coa_m": 1.0, "h_m": -1.0, "5aop_m": 1.0}, "id": "ALASm", "gene_reaction_rule": "211_AT2 or 212_AT1 or 211_AT1 or 23464_AT1"}, {"subsystem": "Glutamate metabolism", "name": "L-alanine transaminase", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["ALATA_L"]}, "metabolites": {"akg_c": -1.0, "glu__L_c": 1.0, "ala__L_c": -1.0, "pyr_c": 1.0}, "id": "ALATA_L", "gene_reaction_rule": "2875_AT1 or 84706_AT1"}, {"subsystem": "Transport, Extracellular", "name": "ALATHRNaEx", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALATHRNaEx"]}, "metabolites": {"ala__L_e": -1.0, "na1_c": 1.0, "ala__L_c": 1.0, "na1_e": -1.0, "thr__L_c": -1.0, "thr__L_e": 1.0}, "id": "ALATHRNaEx", "gene_reaction_rule": "6509_AT1 or 6510_AT1"}, {"subsystem": "Transport, Extracellular", "name": "L alanine reversible transport via proton symport", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["ALAt2r"]}, "metabolites": {"ala__L_e": -1.0, "h_e": -1.0, "ala__L_c": 1.0, "h_c": 1.0}, "id": "ALAt2r", "gene_reaction_rule": "206358_AT1"}, {"subsystem": "Transport, Lysosomal", "name": "ALAt2rL", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["ALAt2rL"]}, "metabolites": {"h_l": -1.0, "ala__L_l": -1.0, "ala__L_c": 1.0, "h_c": 1.0}, "id": "ALAt2rL", "gene_reaction_rule": "206358_AT1"}, {"subsystem": "Transport, Extracellular", "name": "ALAt4", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALAt4"]}, "metabolites": {"ala__L_e": -1.0, "na1_c": 1.0, "ala__L_c": 1.0, "na1_e": -1.0}, "id": "ALAt4", "gene_reaction_rule": "6542_AT1 or 81539_AT1 or 11254_AT1 or 54407_AT1 or 84889_AT1 or 55089_AT1 or 6541_AT1"}, {"subsystem": "Transport, Extracellular", "name": "ALAtN1", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["ALAtN1"]}, "metabolites": {"ala__L_e": -1.0, "na1_c": 2.0, "ala__L_c": 1.0, "na1_e": -2.0, "h_e": 1.0, "h_c": -1.0}, "id": "ALAtN1", "gene_reaction_rule": "10991_AT1 or 92745_AT1"}, {"subsystem": "Transport, Endoplasmic Reticular", "name": "AMPtr", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["AMPtr"]}, "metabolites": {"amp_r": 1.0, "amp_c": -1.0}, "id": "AMPtr", "gene_reaction_rule": ""}, {"subsystem": "Miscellaneous", "name": "Alcohol dehydrogenase (methanol)", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["ALCD1"]}, "metabolites": {"fald_c": 1.0, "nadh_c": 1.0, "h_c": 1.0, "nad_c": -1.0, "meoh_c": -1.0}, "id": "ALCD1", "gene_reaction_rule": "124_AT1 or 131_AT1 or 130_AT1 or (125_AT1 and 124_AT1) or (125_AT1 and 126_AT1) or 128_AT1 or 127_AT1 or (126_AT1 and 124_AT1) or 125_AT1 or 137872_AT1 or 284273_AT1 or 126_AT1 or 284273_AT2"}, {"subsystem": "Pyruvate Metabolism", "name": "ALCD21 D", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALCD21_D"]}, "metabolites": {"h_c": 1.0, "nadh_c": 1.0, "12ppd__R_c": -1.0, "nad_c": -1.0, "lald__D_c": 1.0}, "id": "ALCD21_D", "gene_reaction_rule": "127_AT1 or 284273_AT2 or 125_AT1 or 128_AT1 or 131_AT1 or (125_AT1 and 124_AT1) or 124_AT1 or 130_AT1 or 137872_AT1 or (125_AT1 and 126_AT1) or (126_AT1 and 124_AT1) or 284273_AT1 or 126_AT1"}, {"subsystem": "Pyruvate Metabolism", "name": "ALCD21 L", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALCD21_L"]}, "metabolites": {"nadh_c": 1.0, "12ppd__S_c": -1.0, "nad_c": -1.0, "lald__L_c": 1.0, "h_c": 1.0}, "id": "ALCD21_L", "gene_reaction_rule": "130_AT1 or 125_AT1 or (125_AT1 and 124_AT1) or 128_AT1 or 126_AT1 or 284273_AT2 or 137872_AT1 or 127_AT1 or 124_AT1 or (126_AT1 and 124_AT1) or 284273_AT1 or (125_AT1 and 126_AT1) or 131_AT1"}, {"subsystem": "Pyruvate Metabolism", "name": "(R)-Lactaldehyde:NAD+ oxidoreductase", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALCD22_D"]}, "metabolites": {"nad_c": -1.0, "nadh_c": 1.0, "h_c": 1.0, "mthgxl_c": 1.0, "lald__D_c": -1.0}, "id": "LALDD2", "gene_reaction_rule": "126_AT1 or 137872_AT1 or (126_AT1 and 124_AT1) or 127_AT1 or 130_AT1 or 284273_AT1 or (125_AT1 and 124_AT1) or 128_AT1 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"upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["ASCBt4"]}, "metabolites": {"ascb__L_c": 1.0, "na1_c": 1.0, "na1_e": -1.0, "ascb__L_e": -1.0}, "id": "ASCBt4", "gene_reaction_rule": "9962_AT2 or 9963_AT1 or 9962_AT1 or 9963_AT2"}, {"subsystem": "Transport, Extracellular", "name": "ASNALANaEx", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ASNALANaEx"]}, "metabolites": {"asn__L_e": -1.0, "ala__L_e": 1.0, "na1_c": 1.0, "ala__L_c": -1.0, "na1_e": -1.0, "asn__L_c": 1.0}, "id": "ASNALANaEx", "gene_reaction_rule": "6510_AT1"}, {"subsystem": "Transport, Extracellular", "name": "ASNCYSNaEx", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ASNCYSNaEx"]}, "metabolites": {"cys__L_c": -1.0, "cys__L_e": 1.0, "asn__L_c": 1.0, "na1_c": 1.0, "asn__L_e": -1.0, "na1_e": -1.0}, "id": "ASNCYSNaEx", "gene_reaction_rule": "6510_AT1"}, {"subsystem": "Transport, Extracellular", "name": "ASNGLNNaEx", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ASNGLNNaEx"]}, "metabolites": {"asn__L_c": 1.0, "na1_c": 1.0, "asn__L_e": -1.0, "na1_e": -1.0, "gln__L_e": 1.0, "gln__L_c": -1.0}, "id": "ASNGLNNaEx", "gene_reaction_rule": "6510_AT1"}, {"subsystem": "Alanine and Aspartate Metabolism", "name": "ASNNm", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ASNNm"]}, "metabolites": {"h2o_m": -1.0, "nh4_m": 1.0, "asn__L_m": -1.0, "asp__L_m": 1.0}, "id": "ASNNm", "gene_reaction_rule": "80150_AT1"}, {"subsystem": "Alanine and Aspartate Metabolism", "name": "Asparagine synthase (glutamine-hydrolysing)", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ASNS1"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "asp__L_c": -1.0, "asn__L_c": 1.0, "glu__L_c": 1.0, "amp_c": 1.0, "gln__L_c": -1.0, "ppi_c": 1.0, "h_c": 1.0}, "id": "ASNS1", "gene_reaction_rule": "440_AT1 or 440_AT3 or 440_AT2"}, {"subsystem": "Transport, Extracellular", "name": "ASNSERNaEx", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ASNSERNaEx"]}, "metabolites": {"asn__L_c": 1.0, "na1_c": 1.0, "asn__L_e": -1.0, "na1_e": -1.0, "ser__L_c": -1.0, "ser__L_e": 1.0}, "id": "ASNSERNaEx", "gene_reaction_rule": "6510_AT1"}, {"subsystem": "Transport, Extracellular", "name": "ASNTHRNaEx", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ASNTHRNaEx"]}, "metabolites": {"asn__L_c": 1.0, "na1_c": 1.0, "asn__L_e": -1.0, "na1_e": -1.0, "thr__L_c": -1.0, "thr__L_e": 1.0}, "id": "ASNTHRNaEx", "gene_reaction_rule": "6510_AT1"}, {"subsystem": "Transport, Extracellular", "name": "ASNt4", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ASNt4"]}, "metabolites": {"asn__L_c": 1.0, "na1_c": 1.0, "asn__L_e": -1.0, "na1_e": -1.0}, "id": "ASNt4", "gene_reaction_rule": "81539_AT1 or 11254_AT1 or 54407_AT1 or 55089_AT1"}, {"subsystem": "Transport, Extracellular", "name": "ASNtN1", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["ASNtN1"]}, "metabolites": {"asn__L_c": 1.0, "na1_c": 2.0, "asn__L_e": -1.0, "na1_e": -2.0, "h_e": 1.0, "h_c": -1.0}, "id": "ASNtN1", "gene_reaction_rule": "10991_AT1 or 92745_AT1"}, {"subsystem": "Transport, Mitochondrial", "name": "ASNtm", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ASNtm"]}, "metabolites": {"asn__L_c": -1.0, "asn__L_m": 1.0}, "id": "ASNtm", "gene_reaction_rule": ""}, {"subsystem": "beta-Alanine metabolism", "name": "Aspartate 1-decarboxylase", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ASP1DC"]}, "metabolites": {"asp__L_c": -1.0, "co2_c": 1.0, "h_c": -1.0, "ala_B_c": 1.0}, "id": "ASP1DC", "gene_reaction_rule": "2571_AT1 or 2571_AT2"}, {"subsystem": "Pyrimidine Biosynthesis", "name": "Aspartate carbamoyltransferase", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["ASPCTr"]}, "metabolites": {"asp__L_c": -1.0, "cbasp_c": 1.0, "cbp_c": -1.0, "pi_c": 1.0, "h_c": 1.0}, "id": "ASPCT", "gene_reaction_rule": "790_AT1"}, {"subsystem": "Transport, Extracellular", "name": "ASPDt6", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ASPDt6"]}, "metabolites": {"asp__D_c": 1.0, "asp__D_e": -1.0, "na1_c": 3.0, "na1_e": -3.0, "h_e": -1.0, "h_c": 1.0, "k_c": -1.0, "k_e": 1.0}, "id": "ASPDt6", "gene_reaction_rule": "6511_AT1 or 6505_AT1 or 6507_AT1 or 6506_AT1 or 6512_AT1"}, {"subsystem": "Transport, Peroxisomal", "name": "ASPDxt", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["ASPDxt"]}, "metabolites": {"asp__D_c": 1.0, "asp__D_x": -1.0}, "id": "ASPDxt", "gene_reaction_rule": ""}, {"subsystem": "Transport, Mitochondrial", "name": "ASPGLUm", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["ASPGLUm"]}, "metabolites": {"glu__L_m": 1.0, "asp__L_m": -1.0, "asp__L_c": 1.0, "glu__L_c": -1.0, "h_c": -1.0, "h_m": 1.0}, "id": "ASPGLUm", "gene_reaction_rule": "8604_AT1 or 10165_AT1"}, {"subsystem": "Alanine and Aspartate Metabolism", "name": "ASPNATm", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ASPNATm"]}, "metabolites": {"accoa_m": -1.0, "coa_m": 1.0, "h_m": 1.0, "asp__L_m": -1.0, "Nacasp_m": 1.0}, "id": "ASPNATm", "gene_reaction_rule": ""}, {"subsystem": "Alanine and Aspartate Metabolism", "name": "Aspartate transaminase", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["ASPTA"]}, "metabolites": {"akg_c": -1.0, "asp__L_c": -1.0, "glu__L_c": 1.0, "oaa_c": 1.0}, "id": "ASPTA", "gene_reaction_rule": "2805_AT1"}, {"subsystem": "Alanine and Aspartate Metabolism", "name": "Aspartate transaminase", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["ASPTAm"]}, "metabolites": {"oaa_m": 1.0, "glu__L_m": 1.0, "akg_m": -1.0, "asp__L_m": -1.0}, "id": "ASPTAm", "gene_reaction_rule": "2806_AT1"}, {"subsystem": "Transport, Extracellular", "name": "ASPt6", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ASPt6"]}, "metabolites": {"asp__L_c": 1.0, "na1_c": 3.0, "na1_e": -3.0, "asp__L_e": -1.0, "h_e": -1.0, "h_c": 1.0, "k_c": -1.0, "k_e": 1.0}, "id": "ASPt6", "gene_reaction_rule": "6511_AT1 or 6505_AT1 or 6507_AT1 or 6506_AT1 or 6512_AT1"}, {"subsystem": "Transport, Endoplasmic Reticular", "name": "ATP1ter", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["ATP1ter"]}, "metabolites": {"atp_r": 1.0, "adp_c": 1.0, "atp_c": -1.0, "adp_r": -1.0}, "id": "ATP1ter", "gene_reaction_rule": ""}, {"subsystem": "Transport, Endoplasmic Reticular", "name": "ATP2ter", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["ATP2ter"]}, "metabolites": {"amp_r": -1.0, "amp_c": 1.0, "atp_c": -1.0, "atp_r": 1.0}, "id": "ATP2ter", "gene_reaction_rule": ""}, {"subsystem": "Nucleotides", "name": "ATPH1e", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ATPH1e"]}, "metabolites": {"atp_e": -1.0, "h_e": 2.0, "h2o_e": -2.0, "pi_e": 2.0, "amp_e": 1.0}, "id": "ATPH1e", "gene_reaction_rule": "954_AT1 or 954_AT2 or 953_AT1 or 956_AT1 or 955_AT1 or 957_AT1"}, {"subsystem": "Nucleotides", "name": "ATPH2e", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ATPH2e"]}, "metabolites": {"adp_e": -1.0, "h2o_e": -1.0, "amp_e": 1.0, "h_e": 1.0, "pi_e": 1.0}, "id": "ATPH2e", "gene_reaction_rule": "954_AT2 or 954_AT1 or 953_AT1 or 956_AT1 or 955_AT1 or 957_AT1"}, {"subsystem": "Oxidative Phosphorylation", "name": "ATPS4m", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ATPS4m"]}, "metabolites": {"atp_m": 1.0, "h2o_m": 1.0, "pi_m": -1.0, "adp_m": -1.0, "h_m": 3.0, "h_c": -4.0}, "id": "ATPS4m", "gene_reaction_rule": "((513_AT1 and 498_AT2 and 506_AT1 and 509_AT2 and 514_AT1) or (498_AT2 and 513_AT2 and 514_AT2 and 506_AT1 and 509_AT2) or (513_AT1 and 509_AT1 and 498_AT1 and 514_AT2 and 506_AT1) or (498_AT2 and 513_AT2 and 506_AT1 and 509_AT2 and 514_AT1) or (513_AT2 and 498_AT1 and 514_AT2 and 506_AT1 and 509_AT2) or (513_AT1 and 498_AT1 and 506_AT1 and 509_AT2 and 514_AT1) or (513_AT1 and 498_AT2 and 514_AT2 and 506_AT1 and 509_AT2) or (513_AT1 and 498_AT2 and 509_AT1 and 506_AT1 and 514_AT1) or (498_AT2 and 509_AT1 and 513_AT2 and 506_AT1 and 514_AT1) or (513_AT2 and 498_AT1 and 506_AT1 and 509_AT2 and 514_AT1) or (513_AT2 and 514_AT2 and 506_AT1 and 509_AT2 and 498_AT3) or (513_AT2 and 506_AT1 and 509_AT2 and 498_AT3 and 514_AT1) or (513_AT1 and 509_AT1 and 506_AT1 and 498_AT3 and 514_AT1) or (509_AT1 and 513_AT2 and 514_AT2 and 506_AT1 and 498_AT3) or (513_AT1 and 498_AT2 and 509_AT1 and 514_AT2 and 506_AT1) or (513_AT1 and 498_AT1 and 514_AT2 and 506_AT1 and 509_AT2) or (513_AT1 and 509_AT1 and 498_AT1 and 506_AT1 and 514_AT1) or (513_AT1 and 506_AT1 and 509_AT2 and 498_AT3 and 514_AT1) or (509_AT1 and 513_AT2 and 506_AT1 and 498_AT3 and 514_AT1) or (513_AT1 and 514_AT2 and 506_AT1 and 509_AT2 and 498_AT3) or (509_AT1 and 513_AT2 and 498_AT1 and 506_AT1 and 514_AT1) or (513_AT1 and 509_AT1 and 514_AT2 and 506_AT1 and 498_AT3) or (498_AT2 and 509_AT1 and 513_AT2 and 514_AT2 and 506_AT1) or (509_AT1 and 513_AT2 and 498_AT1 and 514_AT2 and 506_AT1)) and ((4905_AT1 and 516_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 522_AT5) or (518_AT3 and 4905_AT1 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 9551_AT3 and 522_AT3) or (4905_AT1 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 517_AT2 and 9551_AT2 and 522_AT3) or (4905_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 522_AT5 and 518_AT2 and 9551_AT2) or (4905_AT1 and 515_AT2 and 10476_AT2 and 516_AT2 and 521_AT1 and 10632_AT1 and 9551_AT3 and 522_AT5) or (518_AT3 and 4905_AT1 and 9551_AT1 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 522_AT4) or (4905_AT1 and 9551_AT1 and 522_AT2 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 518_AT2) or (518_AT3 and 4905_AT1 and 515_AT3 and 521_AT1 and 10632_AT1 and 10476_AT1 and 522_AT4 and 9551_AT2) or (4905_AT1 and 515_AT3 and 522_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 518_AT2) or (4905_AT1 and 9551_AT1 and 10476_AT2 and 522_AT1 and 516_AT2 and 521_AT1 and 515_AT1 and 10632_AT1) or (517_AT1 and 4905_AT1 and 522_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT2) or (4905_AT1 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 522_AT5 and 518_AT2) or (4905_AT1 and 516_AT1 and 9551_AT1 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 522_AT3) or (4905_AT1 and 9551_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 522_AT4 and 518_AT2) or (4905_AT1 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 9551_AT3 and 522_AT5 and 518_AT2) or (4905_AT1 and 9551_AT1 and 515_AT2 and 10476_AT2 and 516_AT2 and 521_AT1 and 10632_AT1 and 522_AT3) or (4905_AT1 and 516_AT1 and 9551_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 522_AT3) or (4905_AT1 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 522_AT5 and 518_AT2 and 9551_AT2) or (4905_AT1 and 9551_AT1 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 518_AT2 and 522_AT3) or (517_AT1 and 4905_AT1 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 522_AT4) or (4905_AT1 and 10476_AT2 and 522_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 518_AT2 and 9551_AT2) or (4905_AT1 and 522_AT2 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 517_AT2 and 9551_AT2) or (517_AT1 and 4905_AT1 and 9551_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 522_AT4) or (518_AT3 and 4905_AT1 and 515_AT3 and 10476_AT2 and 521_AT1 and 10632_AT1 and 9551_AT3 and 522_AT4) or (4905_AT1 and 515_AT3 and 522_AT1 and 521_AT1 and 10632_AT1 and 10476_AT1 and 518_AT2 and 9551_AT2) or (4905_AT1 and 9551_AT1 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 517_AT2 and 522_AT5) or (4905_AT1 and 10476_AT2 and 516_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 9551_AT3 and 522_AT3) or (518_AT3 and 4905_AT1 and 9551_AT1 and 515_AT3 and 522_AT1 and 521_AT1 and 10632_AT1 and 10476_AT1) or (4905_AT1 and 516_AT1 and 10476_AT2 and 522_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 9551_AT3) or (4905_AT1 and 515_AT3 and 522_AT2 and 10476_AT2 and 516_AT2 and 521_AT1 and 10632_AT1 and 9551_AT3) or (4905_AT1 and 9551_AT1 and 515_AT2 and 10476_AT2 and 521_AT1 and 518_AT1 and 10632_AT1 and 522_AT4) or (517_AT1 and 4905_AT1 and 9551_AT1 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 522_AT5) or (4905_AT1 and 516_AT1 and 515_AT3 and 10476_AT2 and 521_AT1 and 10632_AT1 and 522_AT4 and 9551_AT2) or (4905_AT1 and 515_AT2 and 522_AT1 and 521_AT1 and 10632_AT1 and 10476_AT1 and 517_AT2 and 9551_AT2) or (4905_AT1 and 516_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 522_AT3) or (4905_AT1 and 10476_AT2 and 521_AT1 and 518_AT1 and 515_AT1 and 10632_AT1 and 9551_AT3 and 522_AT3) or (517_AT1 and 4905_AT1 and 9551_AT1 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 522_AT3) or (4905_AT1 and 9551_AT1 and 515_AT3 and 10476_AT2 and 521_AT1 and 10632_AT1 and 518_AT2 and 522_AT3) or (518_AT3 and 4905_AT1 and 9551_AT1 and 522_AT2 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1) or (4905_AT1 and 515_AT3 and 10476_AT2 and 522_AT1 and 521_AT1 and 10632_AT1 and 518_AT2 and 9551_AT2) or (4905_AT1 and 522_AT2 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 518_AT2 and 9551_AT2) or (4905_AT1 and 515_AT3 and 522_AT2 and 10476_AT2 and 521_AT1 and 518_AT1 and 10632_AT1 and 9551_AT2) or (4905_AT1 and 515_AT2 and 10476_AT2 and 521_AT1 and 518_AT1 and 10632_AT1 and 9551_AT2 and 522_AT3) or (4905_AT1 and 522_AT2 and 10476_AT2 and 516_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 9551_AT3) or (4905_AT1 and 516_AT1 and 515_AT3 and 521_AT1 and 10632_AT1 and 10476_AT1 and 522_AT5 and 9551_AT2) or (4905_AT1 and 515_AT3 and 522_AT2 and 516_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3) or (518_AT3 and 4905_AT1 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 9551_AT3 and 522_AT5) or (4905_AT1 and 9551_AT1 and 516_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 522_AT4) or (4905_AT1 and 516_AT1 and 9551_AT1 and 522_AT2 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1) or (4905_AT1 and 521_AT1 and 518_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 522_AT5) or (517_AT1 and 4905_AT1 and 515_AT3 and 522_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT2) or (517_AT1 and 4905_AT1 and 522_AT2 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3) or (4905_AT1 and 516_AT1 and 522_AT2 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 9551_AT2) or (4905_AT1 and 516_AT1 and 515_AT3 and 522_AT1 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT2) or (4905_AT1 and 9551_AT1 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 517_AT2 and 522_AT5) or (4905_AT1 and 515_AT3 and 10476_AT2 and 521_AT1 and 10632_AT1 and 9551_AT3 and 522_AT4 and 518_AT2) or (4905_AT1 and 516_AT1 and 9551_AT1 and 515_AT3 and 10476_AT2 and 522_AT1 and 521_AT1 and 10632_AT1) or (4905_AT1 and 515_AT2 and 521_AT1 and 518_AT1 and 10632_AT1 and 10476_AT1 and 522_AT5 and 9551_AT2) or (4905_AT1 and 9551_AT1 and 522_AT2 and 515_AT2 and 516_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1) or (4905_AT1 and 515_AT3 and 10476_AT2 and 522_AT1 and 521_AT1 and 10632_AT1 and 517_AT2 and 9551_AT3) or (518_AT3 and 4905_AT1 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 522_AT5 and 9551_AT2) or (4905_AT1 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 517_AT2 and 9551_AT2 and 522_AT3) or (517_AT1 and 4905_AT1 and 9551_AT1 and 515_AT3 and 521_AT1 and 10632_AT1 and 10476_AT1 and 522_AT5) or (517_AT1 and 4905_AT1 and 9551_AT1 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 522_AT5) or (4905_AT1 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 517_AT2 and 9551_AT3 and 522_AT4) or (4905_AT1 and 515_AT3 and 522_AT1 and 516_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3) or (518_AT3 and 4905_AT1 and 515_AT3 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 522_AT5) or (4905_AT1 and 522_AT2 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 9551_AT3 and 518_AT2) or (518_AT3 and 4905_AT1 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 9551_AT2 and 522_AT3) or (517_AT1 and 4905_AT1 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 522_AT4 and 9551_AT2) or (4905_AT1 and 9551_AT1 and 515_AT3 and 522_AT1 and 516_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1) or (4905_AT1 and 10476_AT2 and 516_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 522_AT5 and 9551_AT2) or (518_AT3 and 4905_AT1 and 9551_AT1 and 515_AT3 and 10476_AT2 and 521_AT1 and 10632_AT1 and 522_AT3) or (517_AT1 and 4905_AT1 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 9551_AT3 and 522_AT4) or (4905_AT1 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 9551_AT3 and 522_AT4 and 518_AT2) or (4905_AT1 and 9551_AT1 and 515_AT2 and 521_AT1 and 518_AT1 and 10632_AT1 and 10476_AT1 and 522_AT4) or (518_AT3 and 4905_AT1 and 522_AT2 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 9551_AT2) or (4905_AT1 and 515_AT3 and 516_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 522_AT4) or (4905_AT1 and 522_AT2 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 517_AT2 and 9551_AT3) or (4905_AT1 and 516_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 522_AT4 and 9551_AT2) or (4905_AT1 and 515_AT3 and 10476_AT2 and 521_AT1 and 10632_AT1 and 517_AT2 and 9551_AT3 and 522_AT4) or (4905_AT1 and 9551_AT1 and 522_AT2 and 515_AT2 and 10476_AT2 and 516_AT2 and 521_AT1 and 10632_AT1) or (4905_AT1 and 522_AT2 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 9551_AT3 and 518_AT2) or (518_AT3 and 4905_AT1 and 9551_AT1 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 522_AT5) or (517_AT1 and 4905_AT1 and 522_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3) or (4905_AT1 and 9551_AT1 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 522_AT5 and 518_AT2) or (4905_AT1 and 9551_AT1 and 515_AT3 and 521_AT1 and 10632_AT1 and 10476_AT1 and 522_AT5 and 518_AT2) or (4905_AT1 and 9551_AT1 and 515_AT2 and 516_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 522_AT4) or (517_AT1 and 4905_AT1 and 515_AT3 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 522_AT5) or (518_AT3 and 4905_AT1 and 9551_AT1 and 515_AT3 and 522_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1) or (4905_AT1 and 522_AT2 and 521_AT1 and 518_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT2) or (517_AT1 and 4905_AT1 and 10476_AT2 and 522_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 9551_AT2) or (517_AT1 and 4905_AT1 and 9551_AT1 and 515_AT3 and 522_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1) or (518_AT3 and 4905_AT1 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 522_AT5 and 9551_AT2) or (4905_AT1 and 522_AT2 and 515_AT2 and 10476_AT2 and 521_AT1 and 518_AT1 and 10632_AT1 and 9551_AT2) or (4905_AT1 and 522_AT2 and 10476_AT2 and 521_AT1 and 518_AT1 and 515_AT1 and 10632_AT1 and 9551_AT3) or (4905_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 522_AT4 and 518_AT2) or (4905_AT1 and 516_AT1 and 522_AT2 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 9551_AT2) or (4905_AT1 and 515_AT3 and 516_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT2 and 522_AT3) or (4905_AT1 and 522_AT2 and 521_AT1 and 518_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3) or (518_AT3 and 4905_AT1 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 522_AT4) or (4905_AT1 and 516_AT1 and 515_AT3 and 10476_AT2 and 521_AT1 and 10632_AT1 and 9551_AT2 and 522_AT3) or (4905_AT1 and 515_AT2 and 516_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 522_AT3) or (4905_AT1 and 9551_AT1 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 522_AT4 and 518_AT2) or (4905_AT1 and 515_AT3 and 10476_AT2 and 521_AT1 and 10632_AT1 and 518_AT2 and 9551_AT2 and 522_AT3) or (517_AT1 and 4905_AT1 and 9551_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 522_AT5) or (4905_AT1 and 515_AT3 and 522_AT1 and 521_AT1 and 518_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT2) or (518_AT3 and 4905_AT1 and 9551_AT1 and 522_AT2 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1) or (4905_AT1 and 515_AT3 and 522_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 518_AT2 and 9551_AT2) or (4905_AT1 and 9551_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 522_AT5 and 518_AT2) or (518_AT3 and 4905_AT1 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT2 and 522_AT3) or (4905_AT1 and 516_AT1 and 10476_AT2 and 522_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 9551_AT2) or (4905_AT1 and 9551_AT1 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 518_AT2 and 522_AT3) or (4905_AT1 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 518_AT2 and 9551_AT2 and 522_AT3) or (4905_AT1 and 522_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 518_AT2) or (4905_AT1 and 516_AT1 and 522_AT2 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 9551_AT3) or (517_AT1 and 4905_AT1 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 9551_AT2 and 522_AT3) or (517_AT1 and 4905_AT1 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 522_AT5) or (4905_AT1 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 517_AT2 and 9551_AT3 and 522_AT5) or (4905_AT1 and 515_AT2 and 10476_AT2 and 521_AT1 and 518_AT1 and 10632_AT1 and 522_AT5 and 9551_AT2) or (4905_AT1 and 516_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 522_AT4) or (4905_AT1 and 521_AT1 and 518_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 522_AT4) or (4905_AT1 and 9551_AT1 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 517_AT2 and 522_AT3) or (4905_AT1 and 515_AT3 and 10476_AT2 and 521_AT1 and 518_AT1 and 10632_AT1 and 9551_AT2 and 522_AT3) or (4905_AT1 and 515_AT2 and 522_AT1 and 521_AT1 and 518_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT2) or (4905_AT1 and 516_AT1 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 522_AT4) or (4905_AT1 and 9551_AT1 and 522_AT2 and 521_AT1 and 518_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1) or (4905_AT1 and 9551_AT1 and 515_AT3 and 522_AT1 and 521_AT1 and 10632_AT1 and 10476_AT1 and 517_AT2) or (4905_AT1 and 10476_AT2 and 516_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 9551_AT3 and 522_AT4) or (517_AT1 and 4905_AT1 and 515_AT3 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT2 and 522_AT3) or (518_AT3 and 4905_AT1 and 515_AT3 and 10476_AT2 and 522_AT1 and 521_AT1 and 10632_AT1 and 9551_AT2) or (4905_AT1 and 9551_AT1 and 515_AT3 and 10476_AT2 and 521_AT1 and 518_AT1 and 10632_AT1 and 522_AT5) or (4905_AT1 and 10476_AT2 and 516_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 9551_AT2 and 522_AT3) or (4905_AT1 and 9551_AT1 and 515_AT3 and 10476_AT2 and 516_AT2 and 521_AT1 and 10632_AT1 and 522_AT4) or (4905_AT1 and 516_AT1 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 522_AT3) or (4905_AT1 and 516_AT1 and 515_AT3 and 522_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT2) or (518_AT3 and 4905_AT1 and 9551_AT1 and 522_AT2 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1) or (4905_AT1 and 521_AT1 and 518_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 522_AT3) or (4905_AT1 and 516_AT1 and 515_AT3 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 522_AT5) or (4905_AT1 and 515_AT3 and 516_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 522_AT4 and 9551_AT2) or (518_AT3 and 4905_AT1 and 9551_AT1 and 515_AT2 and 522_AT1 and 521_AT1 and 10632_AT1 and 10476_AT1) or (4905_AT1 and 515_AT3 and 522_AT1 and 521_AT1 and 518_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3) or (4905_AT1 and 515_AT3 and 522_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 517_AT2 and 9551_AT3) or (518_AT3 and 4905_AT1 and 515_AT2 and 10476_AT2 and 522_AT1 and 521_AT1 and 10632_AT1 and 9551_AT2) or (517_AT1 and 4905_AT1 and 9551_AT1 and 522_AT2 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1) or (517_AT1 and 4905_AT1 and 522_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT2) or (4905_AT1 and 9551_AT1 and 515_AT3 and 10476_AT2 and 521_AT1 and 518_AT1 and 10632_AT1 and 522_AT4) or (4905_AT1 and 515_AT3 and 516_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 522_AT5) or (517_AT1 and 4905_AT1 and 515_AT3 and 10476_AT2 and 521_AT1 and 10632_AT1 and 522_AT5 and 9551_AT2) or (4905_AT1 and 9551_AT1 and 515_AT2 and 522_AT1 and 516_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1) or (4905_AT1 and 516_AT1 and 9551_AT1 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 522_AT3) or (4905_AT1 and 9551_AT1 and 522_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 517_AT2) or (518_AT3 and 4905_AT1 and 515_AT3 and 10476_AT2 and 521_AT1 and 10632_AT1 and 522_AT4 and 9551_AT2) or (4905_AT1 and 9551_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 517_AT2 and 522_AT3) or (4905_AT1 and 515_AT2 and 10476_AT2 and 516_AT2 and 521_AT1 and 10632_AT1 and 9551_AT3 and 522_AT4) or (4905_AT1 and 9551_AT1 and 515_AT2 and 521_AT1 and 518_AT1 and 10632_AT1 and 10476_AT1 and 522_AT3) or (4905_AT1 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 517_AT2 and 9551_AT3 and 522_AT3) or (4905_AT1 and 10476_AT2 and 522_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 517_AT2 and 9551_AT3) or (517_AT1 and 4905_AT1 and 515_AT3 and 522_AT1 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT2) or (4905_AT1 and 515_AT3 and 522_AT2 and 521_AT1 and 518_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3) or (4905_AT1 and 9551_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 518_AT2 and 522_AT3) or (517_AT1 and 4905_AT1 and 522_AT2 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT2) or (4905_AT1 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 522_AT5 and 518_AT2 and 9551_AT2) or (4905_AT1 and 522_AT2 and 515_AT2 and 521_AT1 and 518_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3) or (4905_AT1 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 518_AT2 and 9551_AT2 and 522_AT3) or (4905_AT1 and 10476_AT2 and 516_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 522_AT4 and 9551_AT2) or (4905_AT1 and 515_AT3 and 522_AT2 and 521_AT1 and 518_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT2) or (4905_AT1 and 515_AT3 and 522_AT1 and 521_AT1 and 10632_AT1 and 10476_AT1 and 517_AT2 and 9551_AT2) or (518_AT3 and 4905_AT1 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 9551_AT3 and 522_AT5) or (4905_AT1 and 516_AT1 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 522_AT5 and 9551_AT2) or (517_AT1 and 4905_AT1 and 522_AT2 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 9551_AT2) or (4905_AT1 and 522_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 518_AT2) or (4905_AT1 and 515_AT2 and 10476_AT2 and 516_AT2 and 521_AT1 and 10632_AT1 and 522_AT4 and 9551_AT2) or (518_AT3 and 4905_AT1 and 9551_AT1 and 515_AT3 and 522_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1) or (4905_AT1 and 515_AT3 and 521_AT1 and 10632_AT1 and 10476_AT1 and 522_AT5 and 518_AT2 and 9551_AT2) or (4905_AT1 and 516_AT1 and 522_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3) or (4905_AT1 and 9551_AT1 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 517_AT2 and 522_AT3) or (4905_AT1 and 515_AT3 and 521_AT1 and 10632_AT1 and 10476_AT1 and 517_AT2 and 9551_AT3 and 522_AT3) or (4905_AT1 and 9551_AT1 and 515_AT3 and 522_AT2 and 516_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1) or (517_AT1 and 4905_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT2 and 522_AT3) or (4905_AT1 and 516_AT1 and 9551_AT1 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 522_AT5) or (4905_AT1 and 522_AT2 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 517_AT2 and 9551_AT3) or (4905_AT1 and 515_AT2 and 522_AT1 and 521_AT1 and 10632_AT1 and 10476_AT1 and 517_AT2 and 9551_AT3) or (518_AT3 and 4905_AT1 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 522_AT5 and 9551_AT2) or (4905_AT1 and 516_AT1 and 515_AT3 and 522_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 9551_AT2) or (4905_AT1 and 516_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 522_AT3) or (518_AT3 and 4905_AT1 and 9551_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 522_AT5) or (4905_AT1 and 515_AT3 and 10476_AT2 and 521_AT1 and 10632_AT1 and 517_AT2 and 9551_AT3 and 522_AT3) or (518_AT3 and 4905_AT1 and 522_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3) or (4905_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 518_AT2 and 9551_AT2 and 522_AT3) or (4905_AT1 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 522_AT4 and 518_AT2 and 9551_AT2) or (4905_AT1 and 521_AT1 and 518_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 522_AT5 and 9551_AT2) or (4905_AT1 and 9551_AT1 and 515_AT3 and 521_AT1 and 518_AT1 and 10632_AT1 and 10476_AT1 and 522_AT5) or (4905_AT1 and 515_AT3 and 10476_AT2 and 521_AT1 and 10632_AT1 and 9551_AT3 and 522_AT5 and 518_AT2) or (4905_AT1 and 9551_AT1 and 515_AT3 and 10476_AT2 and 522_AT1 and 521_AT1 and 10632_AT1 and 517_AT2) or (4905_AT1 and 516_AT1 and 9551_AT1 and 522_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1) or (4905_AT1 and 515_AT2 and 10476_AT2 and 522_AT1 and 516_AT2 and 521_AT1 and 10632_AT1 and 9551_AT2) or (4905_AT1 and 516_AT1 and 515_AT3 and 521_AT1 and 10632_AT1 and 10476_AT1 and 522_AT4 and 9551_AT2) or (4905_AT1 and 9551_AT1 and 522_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 517_AT2) or (4905_AT1 and 516_AT1 and 515_AT3 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT2 and 522_AT3) or (4905_AT1 and 515_AT2 and 10476_AT2 and 522_AT1 and 521_AT1 and 518_AT1 and 10632_AT1 and 9551_AT2) or (4905_AT1 and 10476_AT2 and 521_AT1 and 518_AT1 and 515_AT1 and 10632_AT1 and 9551_AT3 and 522_AT4) or (4905_AT1 and 516_AT1 and 9551_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 522_AT5) or (4905_AT1 and 515_AT3 and 522_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 9551_AT3 and 518_AT2) or (4905_AT1 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 517_AT2 and 9551_AT2 and 522_AT3) or (4905_AT1 and 10476_AT2 and 521_AT1 and 518_AT1 and 515_AT1 and 10632_AT1 and 522_AT4 and 9551_AT2) or (4905_AT1 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 518_AT2 and 522_AT3) or (518_AT3 and 4905_AT1 and 515_AT2 and 522_AT1 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3) or (4905_AT1 and 515_AT3 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 522_AT4 and 518_AT2) or (517_AT1 and 4905_AT1 and 9551_AT1 and 10476_AT2 and 522_AT1 and 521_AT1 and 515_AT1 and 10632_AT1) or (4905_AT1 and 9551_AT1 and 515_AT3 and 521_AT1 and 10632_AT1 and 10476_AT1 and 522_AT4 and 518_AT2) or (4905_AT1 and 515_AT2 and 10476_AT2 and 521_AT1 and 518_AT1 and 10632_AT1 and 9551_AT3 and 522_AT5) or (518_AT3 and 4905_AT1 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 522_AT3) or (4905_AT1 and 9551_AT1 and 522_AT1 and 516_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1) or (4905_AT1 and 515_AT2 and 516_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 522_AT5) or (4905_AT1 and 515_AT3 and 10476_AT2 and 516_AT2 and 521_AT1 and 10632_AT1 and 522_AT5 and 9551_AT2) or (4905_AT1 and 515_AT2 and 522_AT1 and 516_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3) or (517_AT1 and 4905_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 522_AT4) or (4905_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 518_AT2 and 522_AT3) or (4905_AT1 and 9551_AT1 and 515_AT3 and 521_AT1 and 10632_AT1 and 10476_AT1 and 517_AT2 and 522_AT3) or (4905_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 517_AT2 and 9551_AT3 and 522_AT3) or (4905_AT1 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 522_AT5 and 518_AT2 and 9551_AT2) or (517_AT1 and 4905_AT1 and 515_AT2 and 522_AT1 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT2) or (518_AT3 and 4905_AT1 and 9551_AT1 and 515_AT3 and 521_AT1 and 10632_AT1 and 10476_AT1 and 522_AT3) or (518_AT3 and 4905_AT1 and 522_AT2 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 9551_AT3) or (4905_AT1 and 10476_AT2 and 521_AT1 and 518_AT1 and 515_AT1 and 10632_AT1 and 9551_AT2 and 522_AT3) or (517_AT1 and 4905_AT1 and 515_AT3 and 522_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 9551_AT2) or (4905_AT1 and 516_AT1 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 9551_AT3 and 522_AT3) or (518_AT3 and 4905_AT1 and 9551_AT1 and 515_AT3 and 10476_AT2 and 521_AT1 and 10632_AT1 and 522_AT5) or (4905_AT1 and 9551_AT1 and 515_AT3 and 10476_AT2 and 521_AT1 and 10632_AT1 and 517_AT2 and 522_AT5) or (4905_AT1 and 516_AT1 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 9551_AT3 and 522_AT5) or (4905_AT1 and 516_AT1 and 9551_AT1 and 515_AT2 and 10476_AT2 and 522_AT1 and 521_AT1 and 10632_AT1) or (4905_AT1 and 516_AT1 and 9551_AT1 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 522_AT5) or (518_AT3 and 4905_AT1 and 9551_AT1 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 522_AT5) or (517_AT1 and 4905_AT1 and 515_AT3 and 522_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 9551_AT3) or (518_AT3 and 4905_AT1 and 515_AT3 and 10476_AT2 and 521_AT1 and 10632_AT1 and 9551_AT2 and 522_AT3) or (4905_AT1 and 10476_AT2 and 516_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 9551_AT3 and 522_AT5) or (4905_AT1 and 516_AT1 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 522_AT4 and 9551_AT2) or (4905_AT1 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 517_AT2 and 522_AT4 and 9551_AT2) or (4905_AT1 and 10476_AT2 and 521_AT1 and 518_AT1 and 515_AT1 and 10632_AT1 and 522_AT5 and 9551_AT2) or (517_AT1 and 4905_AT1 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 9551_AT3 and 522_AT3) or (4905_AT1 and 9551_AT1 and 522_AT2 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 517_AT2) or (4905_AT1 and 515_AT3 and 10476_AT2 and 516_AT2 and 521_AT1 and 10632_AT1 and 9551_AT3 and 522_AT3) or (4905_AT1 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 9551_AT3 and 522_AT5 and 518_AT2) or (4905_AT1 and 522_AT2 and 10476_AT2 and 516_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 9551_AT2) or (4905_AT1 and 516_AT1 and 522_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3) or (4905_AT1 and 9551_AT1 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 518_AT2 and 522_AT3) or (4905_AT1 and 516_AT1 and 522_AT2 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT2) or (4905_AT1 and 9551_AT1 and 515_AT3 and 521_AT1 and 10632_AT1 and 10476_AT1 and 517_AT2 and 522_AT5) or (517_AT1 and 4905_AT1 and 515_AT3 and 10476_AT2 and 522_AT1 and 521_AT1 and 10632_AT1 and 9551_AT3) or (4905_AT1 and 516_AT1 and 9551_AT1 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 522_AT4) or (518_AT3 and 4905_AT1 and 515_AT3 and 521_AT1 and 10632_AT1 and 10476_AT1 and 522_AT5 and 9551_AT2) or (4905_AT1 and 515_AT2 and 522_AT1 and 516_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT2) or (518_AT3 and 4905_AT1 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 522_AT4 and 9551_AT2) or (517_AT1 and 4905_AT1 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 9551_AT3 and 522_AT5) or (4905_AT1 and 522_AT2 and 516_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3) or (4905_AT1 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 9551_AT3 and 522_AT4 and 518_AT2) or (4905_AT1 and 522_AT1 and 521_AT1 and 518_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3) or (517_AT1 and 4905_AT1 and 9551_AT1 and 515_AT3 and 521_AT1 and 10632_AT1 and 10476_AT1 and 522_AT3) or (518_AT3 and 4905_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 522_AT4) or (4905_AT1 and 515_AT3 and 10476_AT2 and 522_AT1 and 516_AT2 and 521_AT1 and 10632_AT1 and 9551_AT3) or (4905_AT1 and 515_AT3 and 522_AT1 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 518_AT2) or (4905_AT1 and 516_AT1 and 515_AT3 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 522_AT3) or (517_AT1 and 4905_AT1 and 9551_AT1 and 515_AT2 and 522_AT1 and 521_AT1 and 10632_AT1 and 10476_AT1) or (4905_AT1 and 9551_AT1 and 515_AT3 and 521_AT1 and 10632_AT1 and 10476_AT1 and 517_AT2 and 522_AT4) or (4905_AT1 and 9551_AT1 and 515_AT3 and 522_AT2 and 10476_AT2 and 516_AT2 and 521_AT1 and 10632_AT1) or (4905_AT1 and 516_AT1 and 515_AT2 and 10476_AT2 and 522_AT1 and 521_AT1 and 10632_AT1 and 9551_AT2) or (4905_AT1 and 515_AT2 and 521_AT1 and 518_AT1 and 10632_AT1 and 10476_AT1 and 522_AT4 and 9551_AT2) or (518_AT3 and 4905_AT1 and 515_AT3 and 522_AT1 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3) or (4905_AT1 and 522_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 517_AT2 and 9551_AT2) or (4905_AT1 and 516_AT1 and 9551_AT1 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 522_AT5) or (4905_AT1 and 516_AT1 and 9551_AT1 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 522_AT4) or (4905_AT1 and 522_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 517_AT2 and 9551_AT3) or (4905_AT1 and 515_AT2 and 522_AT1 and 521_AT1 and 518_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3) or (518_AT3 and 4905_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 522_AT3) or (517_AT1 and 4905_AT1 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 522_AT5 and 9551_AT2) or (4905_AT1 and 9551_AT1 and 515_AT3 and 10476_AT2 and 522_AT1 and 516_AT2 and 521_AT1 and 10632_AT1) or (4905_AT1 and 9551_AT1 and 10476_AT2 and 522_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 518_AT2) or (4905_AT1 and 9551_AT1 and 515_AT3 and 521_AT1 and 518_AT1 and 10632_AT1 and 10476_AT1 and 522_AT4) or (4905_AT1 and 515_AT3 and 521_AT1 and 10632_AT1 and 10476_AT1 and 517_AT2 and 9551_AT3 and 522_AT5) or (4905_AT1 and 9551_AT1 and 516_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 522_AT5) or (4905_AT1 and 9551_AT1 and 515_AT3 and 521_AT1 and 10632_AT1 and 10476_AT1 and 518_AT2 and 522_AT3) or (518_AT3 and 4905_AT1 and 522_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT2) or (518_AT3 and 4905_AT1 and 9551_AT1 and 515_AT3 and 521_AT1 and 10632_AT1 and 10476_AT1 and 522_AT4) or (517_AT1 and 4905_AT1 and 9551_AT1 and 522_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1) or (518_AT3 and 4905_AT1 and 515_AT3 and 10476_AT2 and 522_AT1 and 521_AT1 and 10632_AT1 and 9551_AT3) or (518_AT3 and 4905_AT1 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 9551_AT3 and 522_AT4) or (4905_AT1 and 9551_AT1 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 517_AT2 and 522_AT4) or (4905_AT1 and 515_AT3 and 10476_AT2 and 522_AT1 and 521_AT1 and 518_AT1 and 10632_AT1 and 9551_AT2) or (4905_AT1 and 9551_AT1 and 515_AT2 and 522_AT1 and 521_AT1 and 518_AT1 and 10632_AT1 and 10476_AT1) or (517_AT1 and 4905_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 522_AT5) or (4905_AT1 and 515_AT3 and 521_AT1 and 518_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 522_AT4) or (4905_AT1 and 9551_AT1 and 515_AT2 and 10476_AT2 and 522_AT1 and 516_AT2 and 521_AT1 and 10632_AT1) or (517_AT1 and 4905_AT1 and 515_AT3 and 10476_AT2 and 522_AT1 and 521_AT1 and 10632_AT1 and 9551_AT2) or (4905_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 517_AT2 and 522_AT5 and 9551_AT2) or (4905_AT1 and 516_AT1 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT2 and 522_AT3) or (517_AT1 and 4905_AT1 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 522_AT4 and 9551_AT2) or (4905_AT1 and 9551_AT1 and 515_AT3 and 10476_AT2 and 521_AT1 and 10632_AT1 and 517_AT2 and 522_AT4) or (518_AT3 and 4905_AT1 and 522_AT2 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 9551_AT3) or (4905_AT1 and 516_AT1 and 515_AT3 and 10476_AT2 and 522_AT1 and 521_AT1 and 10632_AT1 and 9551_AT2) or (4905_AT1 and 516_AT1 and 9551_AT1 and 515_AT3 and 522_AT1 and 521_AT1 and 10632_AT1 and 10476_AT1) or (4905_AT1 and 516_AT1 and 515_AT3 and 10476_AT2 and 522_AT1 and 521_AT1 and 10632_AT1 and 9551_AT3) or (4905_AT1 and 515_AT3 and 516_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 522_AT5 and 9551_AT2) or (4905_AT1 and 515_AT2 and 521_AT1 and 518_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 522_AT4) or (517_AT1 and 4905_AT1 and 9551_AT1 and 515_AT3 and 10476_AT2 and 522_AT1 and 521_AT1 and 10632_AT1) or (4905_AT1 and 522_AT2 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 517_AT2 and 9551_AT2) or (4905_AT1 and 516_AT1 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 9551_AT3 and 522_AT4) or (4905_AT1 and 515_AT3 and 521_AT1 and 10632_AT1 and 10476_AT1 and 517_AT2 and 9551_AT2 and 522_AT3) or (518_AT3 and 4905_AT1 and 9551_AT1 and 515_AT3 and 521_AT1 and 10632_AT1 and 10476_AT1 and 522_AT5) or (4905_AT1 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 9551_AT3 and 518_AT2 and 522_AT3) or (517_AT1 and 4905_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 522_AT4 and 9551_AT2) or (517_AT1 and 4905_AT1 and 515_AT3 and 10476_AT2 and 521_AT1 and 10632_AT1 and 9551_AT3 and 522_AT3) or (4905_AT1 and 9551_AT1 and 515_AT2 and 10476_AT2 and 522_AT1 and 521_AT1 and 10632_AT1 and 518_AT2) or (4905_AT1 and 515_AT3 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 518_AT2 and 522_AT3) or (517_AT1 and 4905_AT1 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 9551_AT3 and 522_AT5) or (4905_AT1 and 522_AT2 and 10476_AT2 and 521_AT1 and 518_AT1 and 515_AT1 and 10632_AT1 and 9551_AT2) or (517_AT1 and 4905_AT1 and 9551_AT1 and 522_AT2 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1) or (4905_AT1 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 517_AT2 and 522_AT5 and 9551_AT2) or (4905_AT1 and 516_AT1 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 522_AT5 and 9551_AT2) or (517_AT1 and 4905_AT1 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 9551_AT3 and 522_AT4) or (4905_AT1 and 515_AT2 and 10476_AT2 and 522_AT1 and 521_AT1 and 10632_AT1 and 518_AT2 and 9551_AT2) or (4905_AT1 and 9551_AT1 and 515_AT3 and 522_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 517_AT2) or (4905_AT1 and 9551_AT1 and 10476_AT2 and 522_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 517_AT2) or (4905_AT1 and 10476_AT2 and 522_AT1 and 516_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 9551_AT2) or (518_AT3 and 4905_AT1 and 9551_AT1 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 522_AT3) or (4905_AT1 and 516_AT1 and 522_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT2) or (4905_AT1 and 516_AT1 and 9551_AT1 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 522_AT3) or (4905_AT1 and 522_AT2 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 517_AT2 and 9551_AT2) or (4905_AT1 and 9551_AT1 and 515_AT2 and 10476_AT2 and 522_AT1 and 521_AT1 and 518_AT1 and 10632_AT1) or (517_AT1 and 4905_AT1 and 9551_AT1 and 515_AT3 and 521_AT1 and 10632_AT1 and 10476_AT1 and 522_AT4) or (4905_AT1 and 9551_AT1 and 515_AT2 and 10476_AT2 and 521_AT1 and 518_AT1 and 10632_AT1 and 522_AT3) or (517_AT1 and 4905_AT1 and 515_AT3 and 10476_AT2 and 521_AT1 and 10632_AT1 and 9551_AT3 and 522_AT5) or (518_AT3 and 4905_AT1 and 9551_AT1 and 515_AT3 and 10476_AT2 and 521_AT1 and 10632_AT1 and 522_AT4) or (4905_AT1 and 10476_AT2 and 522_AT1 and 521_AT1 and 518_AT1 and 515_AT1 and 10632_AT1 and 9551_AT2) or (4905_AT1 and 515_AT3 and 522_AT2 and 10476_AT2 and 521_AT1 and 518_AT1 and 10632_AT1 and 9551_AT3) or (4905_AT1 and 9551_AT1 and 515_AT3 and 516_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 522_AT4) or (4905_AT1 and 9551_AT1 and 515_AT3 and 10476_AT2 and 516_AT2 and 521_AT1 and 10632_AT1 and 522_AT3) or (4905_AT1 and 9551_AT1 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 522_AT5 and 518_AT2) or (4905_AT1 and 522_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 517_AT2 and 9551_AT2) or (4905_AT1 and 516_AT1 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 9551_AT3 and 522_AT4) or (517_AT1 and 4905_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 522_AT5 and 9551_AT2) or (4905_AT1 and 515_AT2 and 10476_AT2 and 522_AT1 and 521_AT1 and 10632_AT1 and 517_AT2 and 9551_AT3) or (4905_AT1 and 9551_AT1 and 522_AT2 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 517_AT2) or (518_AT3 and 4905_AT1 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 9551_AT3 and 522_AT4) or (517_AT1 and 4905_AT1 and 9551_AT1 and 522_AT2 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1) or (4905_AT1 and 515_AT3 and 10476_AT2 and 521_AT1 and 10632_AT1 and 9551_AT3 and 518_AT2 and 522_AT3) or (517_AT1 and 4905_AT1 and 515_AT2 and 10476_AT2 and 522_AT1 and 521_AT1 and 10632_AT1 and 9551_AT3) or (4905_AT1 and 9551_AT1 and 522_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 518_AT2) or (4905_AT1 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 522_AT4 and 518_AT2 and 9551_AT2) or (4905_AT1 and 9551_AT1 and 515_AT3 and 521_AT1 and 518_AT1 and 10632_AT1 and 10476_AT1 and 522_AT3) or (4905_AT1 and 9551_AT1 and 515_AT3 and 522_AT2 and 521_AT1 and 518_AT1 and 10632_AT1 and 10476_AT1) or (518_AT3 and 4905_AT1 and 515_AT3 and 10476_AT2 and 521_AT1 and 10632_AT1 and 522_AT5 and 9551_AT2) or (518_AT3 and 4905_AT1 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 522_AT5) or (4905_AT1 and 515_AT2 and 10476_AT2 and 516_AT2 and 521_AT1 and 10632_AT1 and 9551_AT2 and 522_AT3) or (4905_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 522_AT4 and 518_AT2 and 9551_AT2) or (4905_AT1 and 10476_AT2 and 522_AT1 and 521_AT1 and 518_AT1 and 515_AT1 and 10632_AT1 and 9551_AT3) or (4905_AT1 and 9551_AT1 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 522_AT4 and 518_AT2) or (4905_AT1 and 522_AT1 and 521_AT1 and 518_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT2) or (4905_AT1 and 515_AT2 and 10476_AT2 and 521_AT1 and 518_AT1 and 10632_AT1 and 9551_AT3 and 522_AT3) or (517_AT1 and 4905_AT1 and 515_AT3 and 522_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3) or (4905_AT1 and 522_AT2 and 515_AT2 and 10476_AT2 and 516_AT2 and 521_AT1 and 10632_AT1 and 9551_AT2) or (518_AT3 and 4905_AT1 and 10476_AT2 and 522_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 9551_AT3) or (517_AT1 and 4905_AT1 and 522_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3) or (4905_AT1 and 515_AT3 and 521_AT1 and 10632_AT1 and 10476_AT1 and 518_AT2 and 9551_AT2 and 522_AT3) or (4905_AT1 and 9551_AT1 and 515_AT3 and 522_AT1 and 521_AT1 and 10632_AT1 and 10476_AT1 and 518_AT2) or (4905_AT1 and 515_AT3 and 10476_AT2 and 522_AT1 and 521_AT1 and 10632_AT1 and 517_AT2 and 9551_AT2) or (4905_AT1 and 515_AT3 and 521_AT1 and 10632_AT1 and 10476_AT1 and 517_AT2 and 9551_AT3 and 522_AT4) or (518_AT3 and 4905_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT2 and 522_AT3) or (4905_AT1 and 9551_AT1 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 517_AT2 and 522_AT3) or (4905_AT1 and 515_AT2 and 10476_AT2 and 522_AT1 and 516_AT2 and 521_AT1 and 10632_AT1 and 9551_AT3) or (517_AT1 and 4905_AT1 and 9551_AT1 and 515_AT3 and 10476_AT2 and 521_AT1 and 10632_AT1 and 522_AT5) or (518_AT3 and 4905_AT1 and 515_AT3 and 522_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3) or (518_AT3 and 4905_AT1 and 9551_AT1 and 522_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1) or (4905_AT1 and 515_AT2 and 516_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT2 and 522_AT3) or (4905_AT1 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 517_AT2 and 9551_AT3 and 522_AT5) or (4905_AT1 and 516_AT1 and 515_AT3 and 522_AT1 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3) or (518_AT3 and 4905_AT1 and 9551_AT1 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 522_AT5) or (4905_AT1 and 516_AT1 and 9551_AT1 and 515_AT3 and 522_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1) or (4905_AT1 and 9551_AT1 and 515_AT2 and 516_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 522_AT5) or (4905_AT1 and 521_AT1 and 518_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 522_AT4 and 9551_AT2) or (517_AT1 and 4905_AT1 and 515_AT2 and 10476_AT2 and 522_AT1 and 521_AT1 and 10632_AT1 and 9551_AT2) or (4905_AT1 and 516_AT1 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 522_AT4 and 9551_AT2) or (4905_AT1 and 9551_AT1 and 515_AT3 and 10476_AT2 and 521_AT1 and 518_AT1 and 10632_AT1 and 522_AT3) or (4905_AT1 and 515_AT3 and 10476_AT2 and 521_AT1 and 518_AT1 and 10632_AT1 and 522_AT5 and 9551_AT2) or (4905_AT1 and 516_AT1 and 515_AT3 and 10476_AT2 and 521_AT1 and 10632_AT1 and 522_AT5 and 9551_AT2) or (518_AT3 and 4905_AT1 and 515_AT3 and 522_AT1 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT2) or (4905_AT1 and 516_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 522_AT4 and 9551_AT2) or (4905_AT1 and 516_AT1 and 515_AT3 and 10476_AT2 and 521_AT1 and 10632_AT1 and 9551_AT3 and 522_AT5) or (518_AT3 and 4905_AT1 and 9551_AT1 and 10476_AT2 and 522_AT1 and 521_AT1 and 515_AT1 and 10632_AT1) or (4905_AT1 and 515_AT3 and 522_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 518_AT2 and 9551_AT2) or (4905_AT1 and 522_AT1 and 516_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3) or (4905_AT1 and 515_AT2 and 521_AT1 and 518_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT2 and 522_AT3) or (4905_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 517_AT2 and 9551_AT3 and 522_AT5) or (4905_AT1 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 517_AT2 and 9551_AT3 and 522_AT3) or (4905_AT1 and 9551_AT1 and 515_AT3 and 10476_AT2 and 522_AT1 and 521_AT1 and 10632_AT1 and 518_AT2) or (4905_AT1 and 515_AT3 and 522_AT1 and 521_AT1 and 10632_AT1 and 10476_AT1 and 517_AT2 and 9551_AT3) or (517_AT1 and 4905_AT1 and 9551_AT1 and 515_AT2 and 10476_AT2 and 522_AT1 and 521_AT1 and 10632_AT1) or (4905_AT1 and 9551_AT1 and 515_AT2 and 10476_AT2 and 516_AT2 and 521_AT1 and 10632_AT1 and 522_AT4) or (4905_AT1 and 9551_AT1 and 522_AT2 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 517_AT2) or (4905_AT1 and 516_AT1 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 522_AT4 and 9551_AT2) or (4905_AT1 and 516_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 522_AT5 and 9551_AT2) or (4905_AT1 and 516_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 522_AT5 and 9551_AT2) or (4905_AT1 and 516_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT2 and 522_AT3) or (4905_AT1 and 516_AT1 and 522_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT2) or (517_AT1 and 4905_AT1 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 522_AT4 and 9551_AT2) or (4905_AT1 and 9551_AT1 and 515_AT3 and 516_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 522_AT3) or (4905_AT1 and 10476_AT2 and 521_AT1 and 518_AT1 and 515_AT1 and 10632_AT1 and 9551_AT3 and 522_AT5) or (4905_AT1 and 9551_AT1 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 522_AT5 and 518_AT2) or (517_AT1 and 4905_AT1 and 515_AT3 and 522_AT1 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3) or (4905_AT1 and 515_AT3 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 522_AT5 and 518_AT2) or (4905_AT1 and 522_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 518_AT2 and 9551_AT2) or (517_AT1 and 4905_AT1 and 9551_AT1 and 515_AT3 and 522_AT1 and 521_AT1 and 10632_AT1 and 10476_AT1) or (518_AT3 and 4905_AT1 and 9551_AT1 and 515_AT2 and 10476_AT2 and 522_AT1 and 521_AT1 and 10632_AT1) or (4905_AT1 and 515_AT3 and 521_AT1 and 518_AT1 and 10632_AT1 and 10476_AT1 and 522_AT5 and 9551_AT2) or (518_AT3 and 4905_AT1 and 515_AT3 and 10476_AT2 and 521_AT1 and 10632_AT1 and 9551_AT3 and 522_AT3) or (518_AT3 and 4905_AT1 and 9551_AT1 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 522_AT4) or (517_AT1 and 4905_AT1 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 9551_AT3 and 522_AT3) or (4905_AT1 and 515_AT2 and 10476_AT2 and 516_AT2 and 521_AT1 and 10632_AT1 and 522_AT5 and 9551_AT2) or (4905_AT1 and 9551_AT1 and 10476_AT2 and 521_AT1 and 518_AT1 and 515_AT1 and 10632_AT1 and 522_AT5) or (4905_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 517_AT2 and 9551_AT2 and 522_AT3) or (4905_AT1 and 522_AT2 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 518_AT2 and 9551_AT2) or (4905_AT1 and 515_AT3 and 522_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 517_AT2 and 9551_AT2) or (518_AT3 and 4905_AT1 and 9551_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 522_AT4) or (4905_AT1 and 516_AT1 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 9551_AT3 and 522_AT3) or (518_AT3 and 4905_AT1 and 522_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3) or (518_AT3 and 4905_AT1 and 9551_AT1 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 522_AT3) or (517_AT1 and 4905_AT1 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT2 and 522_AT3) or (4905_AT1 and 9551_AT1 and 10476_AT2 and 521_AT1 and 518_AT1 and 515_AT1 and 10632_AT1 and 522_AT4) or (4905_AT1 and 9551_AT1 and 10476_AT2 and 516_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 522_AT5) or (4905_AT1 and 9551_AT1 and 10476_AT2 and 516_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 522_AT4) or (4905_AT1 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 9551_AT3 and 518_AT2 and 522_AT3) or (4905_AT1 and 9551_AT1 and 522_AT2 and 515_AT2 and 521_AT1 and 518_AT1 and 10632_AT1 and 10476_AT1) or (4905_AT1 and 515_AT2 and 521_AT1 and 518_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 522_AT3) or (4905_AT1 and 515_AT3 and 521_AT1 and 518_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 522_AT3) or (4905_AT1 and 515_AT3 and 10476_AT2 and 516_AT2 and 521_AT1 and 10632_AT1 and 9551_AT3 and 522_AT5) or (4905_AT1 and 516_AT1 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 522_AT5 and 9551_AT2) or (517_AT1 and 4905_AT1 and 9551_AT1 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 522_AT4) or (4905_AT1 and 515_AT2 and 10476_AT2 and 521_AT1 and 518_AT1 and 10632_AT1 and 9551_AT3 and 522_AT4) or (4905_AT1 and 522_AT2 and 515_AT2 and 516_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3) or (4905_AT1 and 515_AT3 and 10476_AT2 and 522_AT1 and 521_AT1 and 518_AT1 and 10632_AT1 and 9551_AT3) or (4905_AT1 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 517_AT2 and 9551_AT3 and 522_AT4) or (4905_AT1 and 9551_AT1 and 515_AT3 and 10476_AT2 and 521_AT1 and 10632_AT1 and 522_AT4 and 518_AT2) or (517_AT1 and 4905_AT1 and 9551_AT1 and 522_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1) or (4905_AT1 and 522_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 517_AT2 and 9551_AT3) or (4905_AT1 and 515_AT3 and 10476_AT2 and 516_AT2 and 521_AT1 and 10632_AT1 and 9551_AT2 and 522_AT3) or (4905_AT1 and 9551_AT1 and 515_AT2 and 10476_AT2 and 522_AT1 and 521_AT1 and 10632_AT1 and 517_AT2) or (4905_AT1 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 522_AT4 and 518_AT2) or (518_AT3 and 4905_AT1 and 10476_AT2 and 522_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 9551_AT2) or (4905_AT1 and 9551_AT1 and 515_AT3 and 10476_AT2 and 522_AT1 and 521_AT1 and 518_AT1 and 10632_AT1) or (4905_AT1 and 9551_AT1 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 517_AT2 and 522_AT4) or (4905_AT1 and 516_AT1 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 9551_AT3 and 522_AT5) or (517_AT1 and 4905_AT1 and 515_AT2 and 522_AT1 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3) or (4905_AT1 and 515_AT3 and 521_AT1 and 10632_AT1 and 10476_AT1 and 522_AT4 and 518_AT2 and 9551_AT2) or (517_AT1 and 4905_AT1 and 515_AT3 and 521_AT1 and 10632_AT1 and 10476_AT1 and 522_AT5 and 9551_AT2) or (518_AT3 and 4905_AT1 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 9551_AT2 and 522_AT3) or (4905_AT1 and 516_AT1 and 515_AT3 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 522_AT4) or (4905_AT1 and 516_AT1 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 522_AT5) or (4905_AT1 and 516_AT1 and 515_AT3 and 10476_AT2 and 521_AT1 and 10632_AT1 and 9551_AT3 and 522_AT4) or (4905_AT1 and 515_AT3 and 521_AT1 and 10632_AT1 and 10476_AT1 and 517_AT2 and 522_AT5 and 9551_AT2) or (4905_AT1 and 515_AT3 and 522_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 517_AT2 and 9551_AT2) or (518_AT3 and 4905_AT1 and 9551_AT1 and 522_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1) or (518_AT3 and 4905_AT1 and 515_AT3 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 522_AT4) or (4905_AT1 and 522_AT2 and 515_AT2 and 521_AT1 and 518_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT2) or (517_AT1 and 4905_AT1 and 522_AT2 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 9551_AT3) or (4905_AT1 and 9551_AT1 and 10476_AT2 and 516_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 522_AT3) or (4905_AT1 and 516_AT1 and 9551_AT1 and 522_AT2 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1) or (4905_AT1 and 522_AT2 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 517_AT2 and 9551_AT3) or (4905_AT1 and 516_AT1 and 9551_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 522_AT4) or (4905_AT1 and 522_AT2 and 515_AT2 and 516_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT2) or (4905_AT1 and 516_AT1 and 9551_AT1 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 522_AT4) or (518_AT3 and 4905_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 522_AT4 and 9551_AT2) or (518_AT3 and 4905_AT1 and 515_AT3 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 522_AT3) or (4905_AT1 and 522_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 518_AT2 and 9551_AT2) or (4905_AT1 and 515_AT3 and 10476_AT2 and 521_AT1 and 518_AT1 and 10632_AT1 and 9551_AT3 and 522_AT3) or (4905_AT1 and 9551_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 517_AT2 and 522_AT4) or (4905_AT1 and 516_AT1 and 9551_AT1 and 515_AT3 and 521_AT1 and 10632_AT1 and 10476_AT1 and 522_AT3) or (4905_AT1 and 516_AT1 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 9551_AT2 and 522_AT3) or (4905_AT1 and 521_AT1 and 518_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT2 and 522_AT3) or (518_AT3 and 4905_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 522_AT5) or (517_AT1 and 4905_AT1 and 9551_AT1 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 522_AT5) or (4905_AT1 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 517_AT2 and 522_AT5 and 9551_AT2) or (4905_AT1 and 9551_AT1 and 522_AT2 and 516_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1) or (4905_AT1 and 516_AT1 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 9551_AT2 and 522_AT3) or (4905_AT1 and 9551_AT1 and 521_AT1 and 518_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 522_AT4) or (4905_AT1 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 517_AT2 and 522_AT4 and 9551_AT2) or (518_AT3 and 4905_AT1 and 515_AT3 and 522_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 9551_AT3) or (4905_AT1 and 516_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT2 and 522_AT3) or (518_AT3 and 4905_AT1 and 515_AT2 and 10476_AT2 and 522_AT1 and 521_AT1 and 10632_AT1 and 9551_AT3) or (517_AT1 and 4905_AT1 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 522_AT5 and 9551_AT2) or (4905_AT1 and 9551_AT1 and 515_AT2 and 521_AT1 and 518_AT1 and 10632_AT1 and 10476_AT1 and 522_AT5) or (4905_AT1 and 9551_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 517_AT2 and 522_AT5) or (517_AT1 and 4905_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 522_AT3) or (4905_AT1 and 515_AT2 and 516_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 522_AT4) or (4905_AT1 and 515_AT2 and 10476_AT2 and 522_AT1 and 521_AT1 and 10632_AT1 and 9551_AT3 and 518_AT2) or (4905_AT1 and 515_AT3 and 521_AT1 and 518_AT1 and 10632_AT1 and 10476_AT1 and 522_AT4 and 9551_AT2) or (517_AT1 and 4905_AT1 and 522_AT2 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 9551_AT3) or (4905_AT1 and 515_AT3 and 10476_AT2 and 521_AT1 and 518_AT1 and 10632_AT1 and 522_AT4 and 9551_AT2) or (517_AT1 and 4905_AT1 and 515_AT3 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 522_AT4) or (517_AT1 and 4905_AT1 and 9551_AT1 and 515_AT3 and 522_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1) or (4905_AT1 and 522_AT2 and 516_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT2) or (4905_AT1 and 516_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 522_AT5) or (4905_AT1 and 516_AT1 and 9551_AT1 and 515_AT3 and 10476_AT2 and 521_AT1 and 10632_AT1 and 522_AT4) or (4905_AT1 and 515_AT3 and 10476_AT2 and 521_AT1 and 10632_AT1 and 522_AT4 and 518_AT2 and 9551_AT2) or (4905_AT1 and 516_AT1 and 515_AT2 and 522_AT1 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3) or (4905_AT1 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 517_AT2 and 522_AT4 and 9551_AT2) or (518_AT3 and 4905_AT1 and 522_AT2 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT2) or (4905_AT1 and 516_AT1 and 515_AT3 and 10476_AT2 and 521_AT1 and 10632_AT1 and 9551_AT3 and 522_AT3) or (4905_AT1 and 515_AT2 and 10476_AT2 and 522_AT1 and 521_AT1 and 518_AT1 and 10632_AT1 and 9551_AT3) or (4905_AT1 and 522_AT2 and 515_AT2 and 10476_AT2 and 516_AT2 and 521_AT1 and 10632_AT1 and 9551_AT3) or (4905_AT1 and 9551_AT1 and 515_AT3 and 522_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 517_AT2) or (4905_AT1 and 522_AT2 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 518_AT2) or (4905_AT1 and 9551_AT1 and 515_AT3 and 522_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 518_AT2) or (4905_AT1 and 10476_AT2 and 522_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 9551_AT3 and 518_AT2) or (4905_AT1 and 9551_AT1 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 517_AT2 and 522_AT5) or (4905_AT1 and 9551_AT1 and 522_AT2 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 518_AT2) or (4905_AT1 and 515_AT3 and 10476_AT2 and 521_AT1 and 10632_AT1 and 517_AT2 and 522_AT5 and 9551_AT2) or (517_AT1 and 4905_AT1 and 9551_AT1 and 515_AT3 and 10476_AT2 and 521_AT1 and 10632_AT1 and 522_AT3) or (518_AT3 and 4905_AT1 and 515_AT3 and 522_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 9551_AT2) or (4905_AT1 and 515_AT2 and 10476_AT2 and 516_AT2 and 521_AT1 and 10632_AT1 and 9551_AT3 and 522_AT3) or (4905_AT1 and 515_AT3 and 522_AT1 and 516_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT2) or (4905_AT1 and 515_AT3 and 10476_AT2 and 521_AT1 and 10632_AT1 and 517_AT2 and 9551_AT3 and 522_AT5) or (4905_AT1 and 9551_AT1 and 515_AT3 and 10476_AT2 and 516_AT2 and 521_AT1 and 10632_AT1 and 522_AT5) or (4905_AT1 and 9551_AT1 and 522_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 518_AT2) or (4905_AT1 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 517_AT2 and 9551_AT3 and 522_AT3) or (4905_AT1 and 515_AT2 and 516_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 522_AT5 and 9551_AT2) or (4905_AT1 and 516_AT1 and 9551_AT1 and 515_AT3 and 10476_AT2 and 521_AT1 and 10632_AT1 and 522_AT3) or (4905_AT1 and 9551_AT1 and 515_AT3 and 10476_AT2 and 521_AT1 and 10632_AT1 and 522_AT5 and 518_AT2) or (4905_AT1 and 515_AT3 and 10476_AT2 and 516_AT2 and 521_AT1 and 10632_AT1 and 9551_AT3 and 522_AT4) or (4905_AT1 and 516_AT1 and 9551_AT1 and 522_AT2 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1) or (4905_AT1 and 515_AT3 and 521_AT1 and 10632_AT1 and 10476_AT1 and 517_AT2 and 522_AT4 and 9551_AT2) or (4905_AT1 and 515_AT3 and 10476_AT2 and 522_AT1 and 521_AT1 and 10632_AT1 and 9551_AT3 and 518_AT2) or (517_AT1 and 4905_AT1 and 522_AT2 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 9551_AT2) or (4905_AT1 and 516_AT1 and 515_AT2 and 10476_AT2 and 522_AT1 and 521_AT1 and 10632_AT1 and 9551_AT3) or (4905_AT1 and 515_AT3 and 10476_AT2 and 521_AT1 and 518_AT1 and 10632_AT1 and 9551_AT3 and 522_AT5) or (4905_AT1 and 515_AT3 and 10476_AT2 and 516_AT2 and 521_AT1 and 10632_AT1 and 522_AT4 and 9551_AT2) or (4905_AT1 and 9551_AT1 and 522_AT1 and 521_AT1 and 518_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1) or (4905_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 517_AT2 and 522_AT4 and 9551_AT2) or (4905_AT1 and 516_AT1 and 9551_AT1 and 522_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1) or (4905_AT1 and 515_AT3 and 10476_AT2 and 521_AT1 and 10632_AT1 and 517_AT2 and 9551_AT2 and 522_AT3) or (4905_AT1 and 9551_AT1 and 522_AT2 and 10476_AT2 and 521_AT1 and 518_AT1 and 515_AT1 and 10632_AT1) or (518_AT3 and 4905_AT1 and 522_AT2 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 9551_AT2) or (4905_AT1 and 515_AT3 and 10476_AT2 and 521_AT1 and 10632_AT1 and 522_AT5 and 518_AT2 and 9551_AT2) or (518_AT3 and 4905_AT1 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 522_AT4 and 9551_AT2) or (4905_AT1 and 516_AT1 and 9551_AT1 and 515_AT2 and 522_AT1 and 521_AT1 and 10632_AT1 and 10476_AT1) or (517_AT1 and 4905_AT1 and 515_AT3 and 521_AT1 and 10632_AT1 and 10476_AT1 and 522_AT4 and 9551_AT2) or (517_AT1 and 4905_AT1 and 9551_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 522_AT3) or (517_AT1 and 4905_AT1 and 515_AT3 and 10476_AT2 and 521_AT1 and 10632_AT1 and 522_AT4 and 9551_AT2) or (4905_AT1 and 9551_AT1 and 522_AT2 and 10476_AT2 and 516_AT2 and 521_AT1 and 515_AT1 and 10632_AT1) or (4905_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 522_AT5 and 518_AT2) or (517_AT1 and 4905_AT1 and 9551_AT1 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 522_AT3) or (517_AT1 and 4905_AT1 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 522_AT5 and 9551_AT2) or (518_AT3 and 4905_AT1 and 515_AT3 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT2 and 522_AT3) or (518_AT3 and 4905_AT1 and 9551_AT1 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 522_AT3) or (4905_AT1 and 515_AT2 and 10476_AT2 and 521_AT1 and 518_AT1 and 10632_AT1 and 522_AT4 and 9551_AT2) or (4905_AT1 and 522_AT2 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 518_AT2 and 9551_AT2) or (517_AT1 and 4905_AT1 and 10476_AT2 and 522_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 9551_AT3) or (4905_AT1 and 515_AT2 and 522_AT1 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 518_AT2) or (4905_AT1 and 9551_AT1 and 515_AT3 and 522_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 518_AT2) or (4905_AT1 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 522_AT4 and 518_AT2 and 9551_AT2) or (4905_AT1 and 9551_AT1 and 515_AT2 and 516_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 522_AT3) or (517_AT1 and 4905_AT1 and 9551_AT1 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 522_AT4) or (4905_AT1 and 515_AT3 and 521_AT1 and 518_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT2 and 522_AT3) or (4905_AT1 and 9551_AT1 and 515_AT3 and 10476_AT2 and 521_AT1 and 10632_AT1 and 517_AT2 and 522_AT3) or (4905_AT1 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 518_AT2 and 9551_AT2 and 522_AT3) or (4905_AT1 and 9551_AT1 and 515_AT2 and 522_AT1 and 521_AT1 and 10632_AT1 and 10476_AT1 and 517_AT2) or (4905_AT1 and 522_AT1 and 516_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT2) or (4905_AT1 and 516_AT1 and 522_AT2 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3) or (4905_AT1 and 9551_AT1 and 10476_AT2 and 522_AT1 and 521_AT1 and 518_AT1 and 515_AT1 and 10632_AT1) or (4905_AT1 and 516_AT1 and 9551_AT1 and 515_AT3 and 521_AT1 and 10632_AT1 and 10476_AT1 and 522_AT4) or (4905_AT1 and 9551_AT1 and 515_AT3 and 522_AT1 and 521_AT1 and 518_AT1 and 10632_AT1 and 10476_AT1) or (4905_AT1 and 10476_AT2 and 522_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 517_AT2 and 9551_AT2) or (517_AT1 and 4905_AT1 and 9551_AT1 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 522_AT3) or (4905_AT1 and 516_AT1 and 9551_AT1 and 515_AT3 and 10476_AT2 and 521_AT1 and 10632_AT1 and 522_AT5) or (518_AT3 and 4905_AT1 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 522_AT4 and 9551_AT2) or (4905_AT1 and 515_AT3 and 521_AT1 and 518_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 522_AT5) or (4905_AT1 and 9551_AT1 and 516_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 522_AT3) or (517_AT1 and 4905_AT1 and 9551_AT1 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 522_AT4) or (4905_AT1 and 9551_AT1 and 521_AT1 and 518_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 522_AT3) or (517_AT1 and 4905_AT1 and 515_AT3 and 10476_AT2 and 521_AT1 and 10632_AT1 and 9551_AT3 and 522_AT4) or (518_AT3 and 4905_AT1 and 515_AT3 and 10476_AT2 and 521_AT1 and 10632_AT1 and 9551_AT3 and 522_AT5) or (518_AT3 and 4905_AT1 and 9551_AT1 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 522_AT4) or (4905_AT1 and 516_AT1 and 522_AT2 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 9551_AT3) or (4905_AT1 and 516_AT1 and 9551_AT1 and 10476_AT2 and 522_AT1 and 521_AT1 and 515_AT1 and 10632_AT1) or (4905_AT1 and 9551_AT1 and 522_AT2 and 515_AT2 and 10476_AT2 and 521_AT1 and 518_AT1 and 10632_AT1) or (4905_AT1 and 516_AT1 and 515_AT2 and 522_AT1 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT2) or (4905_AT1 and 522_AT2 and 515_AT2 and 10476_AT2 and 521_AT1 and 518_AT1 and 10632_AT1 and 9551_AT3) or (4905_AT1 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 517_AT2 and 522_AT5 and 9551_AT2) or (4905_AT1 and 515_AT2 and 521_AT1 and 518_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 522_AT5) or (518_AT3 and 4905_AT1 and 9551_AT1 and 515_AT3 and 10476_AT2 and 522_AT1 and 521_AT1 and 10632_AT1) or (4905_AT1 and 9551_AT1 and 515_AT3 and 522_AT2 and 10476_AT2 and 521_AT1 and 518_AT1 and 10632_AT1) or (4905_AT1 and 9551_AT1 and 515_AT2 and 522_AT1 and 521_AT1 and 10632_AT1 and 10476_AT1 and 518_AT2) or (518_AT3 and 4905_AT1 and 522_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT2) or (4905_AT1 and 515_AT3 and 522_AT2 and 516_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT2) or (4905_AT1 and 9551_AT1 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 522_AT4 and 518_AT2) or (4905_AT1 and 516_AT1 and 515_AT3 and 522_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3) or (4905_AT1 and 515_AT2 and 10476_AT2 and 522_AT1 and 521_AT1 and 10632_AT1 and 517_AT2 and 9551_AT2) or (4905_AT1 and 10476_AT2 and 522_AT1 and 516_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 9551_AT3) or (4905_AT1 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 517_AT2 and 9551_AT3 and 522_AT5) or (517_AT1 and 4905_AT1 and 515_AT3 and 10476_AT2 and 521_AT1 and 10632_AT1 and 9551_AT2 and 522_AT3) or (518_AT3 and 4905_AT1 and 9551_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 522_AT3) or (4905_AT1 and 516_AT1 and 515_AT3 and 522_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 9551_AT3) or (4905_AT1 and 516_AT1 and 9551_AT1 and 515_AT3 and 521_AT1 and 10632_AT1 and 10476_AT1 and 522_AT5) or (4905_AT1 and 515_AT2 and 522_AT1 and 521_AT1 and 10632_AT1 and 10476_AT1 and 518_AT2 and 9551_AT2) or (4905_AT1 and 515_AT3 and 10476_AT2 and 521_AT1 and 10632_AT1 and 517_AT2 and 522_AT4 and 9551_AT2) or (4905_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 517_AT2 and 9551_AT3 and 522_AT4) or (4905_AT1 and 9551_AT1 and 515_AT2 and 10476_AT2 and 521_AT1 and 518_AT1 and 10632_AT1 and 522_AT5) or (4905_AT1 and 9551_AT1 and 10476_AT2 and 521_AT1 and 518_AT1 and 515_AT1 and 10632_AT1 and 522_AT3) or (4905_AT1 and 9551_AT1 and 522_AT2 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 518_AT2) or (4905_AT1 and 515_AT3 and 522_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 517_AT2 and 9551_AT3) or (518_AT3 and 4905_AT1 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 9551_AT3 and 522_AT3) or (517_AT1 and 4905_AT1 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 522_AT3) or (4905_AT1 and 515_AT3 and 10476_AT2 and 521_AT1 and 518_AT1 and 10632_AT1 and 9551_AT3 and 522_AT4) or (4905_AT1 and 9551_AT1 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 517_AT2 and 522_AT4) or (518_AT3 and 4905_AT1 and 515_AT2 and 522_AT1 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT2) or (518_AT3 and 4905_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 522_AT5 and 9551_AT2) or (4905_AT1 and 515_AT2 and 516_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 522_AT4 and 9551_AT2) or (4905_AT1 and 515_AT3 and 10476_AT2 and 522_AT1 and 516_AT2 and 521_AT1 and 10632_AT1 and 9551_AT2) or (517_AT1 and 4905_AT1 and 10476_AT2 and 521_AT1 and 515_AT1 and 10632_AT1 and 9551_AT2 and 522_AT3) or (517_AT1 and 4905_AT1 and 9551_AT1 and 515_AT3 and 10476_AT2 and 521_AT1 and 10632_AT1 and 522_AT4) or (4905_AT1 and 515_AT3 and 516_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 522_AT3) or (4905_AT1 and 516_AT1 and 9551_AT1 and 515_AT3 and 522_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1) or (518_AT3 and 4905_AT1 and 522_AT2 and 515_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3) or (4905_AT1 and 515_AT2 and 10476_AT2 and 521_AT1 and 10632_AT1 and 517_AT2 and 9551_AT3 and 522_AT4) or (518_AT3 and 4905_AT1 and 515_AT3 and 522_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT2) or (4905_AT1 and 9551_AT1 and 521_AT1 and 518_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 522_AT5) or (4905_AT1 and 515_AT3 and 522_AT2 and 10476_AT2 and 516_AT2 and 521_AT1 and 10632_AT1 and 9551_AT2) or (4905_AT1 and 516_AT1 and 521_AT1 and 515_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 522_AT4) or (4905_AT1 and 9551_AT1 and 515_AT3 and 516_AT2 and 521_AT1 and 10632_AT1 and 10476_AT1 and 522_AT5) or (4905_AT1 and 9551_AT1 and 515_AT2 and 10476_AT2 and 516_AT2 and 521_AT1 and 10632_AT1 and 522_AT5) or (517_AT1 and 4905_AT1 and 515_AT3 and 521_AT1 and 10632_AT1 and 10476_AT1 and 9551_AT3 and 522_AT3))"}, {"subsystem": "Transport, Lysosomal", "name": "ATPasel", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ATPasel"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "h_c": -3.0, "adp_c": 1.0, "h_l": 4.0, "pi_c": 1.0}, "id": "ATPasel", "gene_reaction_rule": "((50617_AT1 and 533_AT1 and 527_AT1 and 8992_AT1 and 245972_AT1) or (50617_AT1 and 533_AT1 and 527_AT1 and 8992_AT1 and 9114_AT1) or (533_AT1 and 527_AT1 and 8992_AT1 and 535_AT1 and 245972_AT1) or (533_AT1 and 527_AT1 and 8992_AT1 and 535_AT1 and 9114_AT1) or (533_AT1 and 527_AT1 and 8992_AT1 and 50617_AT3 and 245972_AT1) or (533_AT1 and 527_AT1 and 8992_AT1 and 10312_AT1 and 9114_AT1) or (533_AT1 and 527_AT1 and 8992_AT1 and 245972_AT1 and 50617_AT2) or (533_AT1 and 527_AT1 and 8992_AT1 and 9114_AT1 and 23545_AT1) or (533_AT1 and 527_AT1 and 8992_AT1 and 10312_AT2 and 245972_AT1) or (533_AT1 and 527_AT1 and 8992_AT1 and 50617_AT3 and 9114_AT1) or (533_AT1 and 527_AT1 and 8992_AT1 and 245972_AT1 and 23545_AT1) or (533_AT1 and 527_AT1 and 8992_AT1 and 9114_AT1 and 50617_AT2) or (533_AT1 and 527_AT1 and 8992_AT1 and 10312_AT1 and 245972_AT1) or (533_AT1 and 527_AT1 and 8992_AT1 and 10312_AT2 and 9114_AT1)) and ((51382_AT1 and 9296_AT1 and 245973_AT1 and 9550_AT1 and 529_AT1 and 523_AT1 and 51606_AT1 and 526_AT1) or (51382_AT1 and 9296_AT1 and 127124_AT1 and 245973_AT1 and 525_AT1 and 90423_AT1 and 51606_AT2 and 523_AT1) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 534_AT2 and 90423_AT1 and 523_AT1 and 526_AT1 and 528_AT2) or (51382_AT1 and 9296_AT1 and 245973_AT1 and 534_AT2 and 90423_AT1 and 523_AT1 and 51606_AT1 and 526_AT1) or (51382_AT1 and 9296_AT1 and 534_AT1 and 51606_AT2 and 529_AT1 and 528_AT1 and 523_AT1 and 526_AT1) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 534_AT1 and 529_AT1 and 523_AT1 and 526_AT1 and 528_AT2) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 127124_AT1 and 525_AT1 and 529_AT1 and 523_AT1 and 528_AT2) or (51382_AT1 and 9296_AT1 and 245973_AT1 and 90423_AT1 and 127124_AT2 and 51606_AT2 and 523_AT1 and 526_AT1) or (51382_AT1 and 9296_AT1 and 127124_AT1 and 525_AT1 and 529_AT1 and 523_AT1 and 51606_AT1 and 528_AT2) or (51382_AT1 and 9296_AT1 and 245973_AT1 and 534_AT2 and 525_AT1 and 51606_AT2 and 529_AT1 and 523_AT1) or (51382_AT1 and 9296_AT1 and 534_AT1 and 90423_AT1 and 528_AT1 and 523_AT1 and 51606_AT1 and 526_AT1) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 90423_AT1 and 9550_AT1 and 523_AT1 and 526_AT1 and 528_AT2) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 534_AT1 and 245973_AT1 and 525_AT1 and 90423_AT1 and 523_AT1) or (51382_AT1 and 9296_AT1 and 534_AT1 and 525_AT1 and 529_AT1 and 528_AT1 and 523_AT1 and 51606_AT1) or (51382_AT1 and 9296_AT1 and 90423_AT1 and 127124_AT2 and 51606_AT2 and 523_AT1 and 526_AT1 and 528_AT2) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 534_AT1 and 90423_AT1 and 528_AT1 and 523_AT1 and 526_AT1) or (51382_AT1 and 9296_AT1 and 525_AT1 and 127124_AT2 and 51606_AT2 and 529_AT1 and 523_AT1 and 528_AT2) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 534_AT1 and 525_AT1 and 529_AT1 and 528_AT1 and 523_AT1) or (51382_AT1 and 9296_AT1 and 127124_AT2 and 529_AT1 and 523_AT1 and 51606_AT1 and 526_AT1 and 528_AT2) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 534_AT2 and 525_AT1 and 90423_AT1 and 528_AT1 and 523_AT1) or (51382_AT1 and 9296_AT1 and 534_AT2 and 90423_AT1 and 51606_AT2 and 523_AT1 and 526_AT1 and 528_AT2) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 525_AT1 and 90423_AT1 and 9550_AT1 and 523_AT1 and 528_AT2) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 534_AT1 and 525_AT1 and 90423_AT1 and 528_AT1 and 523_AT1) or (51382_AT1 and 9296_AT1 and 127124_AT1 and 245973_AT1 and 525_AT1 and 90423_AT1 and 523_AT1 and 51606_AT1) or (51382_AT1 and 9296_AT1 and 245973_AT1 and 525_AT1 and 90423_AT1 and 127124_AT2 and 51606_AT2 and 523_AT1) or (51382_AT1 and 9296_AT1 and 534_AT1 and 525_AT1 and 51606_AT2 and 529_AT1 and 523_AT1 and 528_AT2) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 127124_AT1 and 529_AT1 and 528_AT1 and 523_AT1 and 526_AT1) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 127124_AT1 and 90423_AT1 and 523_AT1 and 526_AT1 and 528_AT2) or (51382_AT1 and 9296_AT1 and 127124_AT1 and 529_AT1 and 523_AT1 and 51606_AT1 and 526_AT1 and 528_AT2) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 525_AT1 and 90423_AT1 and 127124_AT2 and 528_AT1 and 523_AT1) or (51382_AT1 and 9296_AT1 and 90423_AT1 and 127124_AT2 and 51606_AT2 and 528_AT1 and 523_AT1 and 526_AT1) or (51382_AT1 and 9296_AT1 and 245973_AT1 and 534_AT2 and 525_AT1 and 90423_AT1 and 51606_AT2 and 523_AT1) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 127124_AT1 and 245973_AT1 and 529_AT1 and 523_AT1 and 526_AT1) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 245973_AT1 and 90423_AT1 and 9550_AT1 and 523_AT1 and 526_AT1) or (51382_AT1 and 9296_AT1 and 534_AT2 and 90423_AT1 and 528_AT1 and 523_AT1 and 51606_AT1 and 526_AT1) or (51382_AT1 and 9296_AT1 and 127124_AT1 and 525_AT1 and 90423_AT1 and 51606_AT2 and 528_AT1 and 523_AT1) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 534_AT2 and 525_AT1 and 529_AT1 and 523_AT1 and 528_AT2) or (51382_AT1 and 9296_AT1 and 127124_AT1 and 245973_AT1 and 51606_AT2 and 529_AT1 and 523_AT1 and 526_AT1) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 127124_AT2 and 529_AT1 and 528_AT1 and 523_AT1 and 526_AT1) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 534_AT2 and 90423_AT1 and 528_AT1 and 523_AT1 and 526_AT1) or (51382_AT1 and 9296_AT1 and 534_AT1 and 51606_AT2 and 529_AT1 and 523_AT1 and 526_AT1 and 528_AT2) or (51382_AT1 and 9296_AT1 and 534_AT2 and 529_AT1 and 528_AT1 and 523_AT1 and 51606_AT1 and 526_AT1) or (51382_AT1 and 9296_AT1 and 534_AT1 and 90423_AT1 and 51606_AT2 and 523_AT1 and 526_AT1 and 528_AT2) or (51382_AT1 and 9296_AT1 and 127124_AT1 and 529_AT1 and 528_AT1 and 523_AT1 and 51606_AT1 and 526_AT1) or (51382_AT1 and 9296_AT1 and 127124_AT1 and 90423_AT1 and 51606_AT2 and 528_AT1 and 523_AT1 and 526_AT1) or (51382_AT1 and 9296_AT1 and 9550_AT1 and 529_AT1 and 528_AT1 and 523_AT1 and 51606_AT1 and 526_AT1) or (51382_AT1 and 9296_AT1 and 534_AT2 and 525_AT1 and 51606_AT2 and 529_AT1 and 528_AT1 and 523_AT1) or (51382_AT1 and 9296_AT1 and 245973_AT1 and 127124_AT2 and 529_AT1 and 523_AT1 and 51606_AT1 and 526_AT1) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 245973_AT1 and 9550_AT1 and 529_AT1 and 523_AT1 and 526_AT1) or (51382_AT1 and 9296_AT1 and 127124_AT1 and 525_AT1 and 90423_AT1 and 51606_AT2 and 523_AT1 and 528_AT2) or (51382_AT1 and 9296_AT1 and 127124_AT1 and 525_AT1 and 51606_AT2 and 529_AT1 and 523_AT1 and 528_AT2) or (51382_AT1 and 9296_AT1 and 127124_AT2 and 51606_AT2 and 529_AT1 and 523_AT1 and 526_AT1 and 528_AT2) or (51382_AT1 and 9296_AT1 and 90423_AT1 and 9550_AT1 and 523_AT1 and 51606_AT1 and 526_AT1 and 528_AT2) or (51382_AT1 and 9296_AT1 and 534_AT1 and 525_AT1 and 90423_AT1 and 51606_AT2 and 528_AT1 and 523_AT1) or (51382_AT1 and 9296_AT1 and 127124_AT1 and 525_AT1 and 51606_AT2 and 529_AT1 and 528_AT1 and 523_AT1) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 245973_AT1 and 534_AT2 and 529_AT1 and 523_AT1 and 526_AT1) or (51382_AT1 and 9296_AT1 and 534_AT2 and 525_AT1 and 51606_AT2 and 529_AT1 and 523_AT1 and 528_AT2) or (51382_AT1 and 9296_AT1 and 245973_AT1 and 90423_AT1 and 9550_AT1 and 523_AT1 and 51606_AT1 and 526_AT1) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 9550_AT1 and 529_AT1 and 528_AT1 and 523_AT1 and 526_AT1) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 525_AT1 and 127124_AT2 and 529_AT1 and 528_AT1 and 523_AT1) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 525_AT1 and 90423_AT1 and 9550_AT1 and 528_AT1 and 523_AT1) or (51382_AT1 and 9296_AT1 and 245973_AT1 and 525_AT1 and 127124_AT2 and 529_AT1 and 523_AT1 and 51606_AT1) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 534_AT1 and 525_AT1 and 90423_AT1 and 523_AT1 and 528_AT2) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 245973_AT1 and 525_AT1 and 90423_AT1 and 9550_AT1 and 523_AT1) or (51382_AT1 and 9296_AT1 and 245973_AT1 and 127124_AT2 and 51606_AT2 and 529_AT1 and 523_AT1 and 526_AT1) or (51382_AT1 and 9296_AT1 and 245973_AT1 and 90423_AT1 and 127124_AT2 and 523_AT1 and 51606_AT1 and 526_AT1) or (51382_AT1 and 9296_AT1 and 534_AT2 and 51606_AT2 and 529_AT1 and 523_AT1 and 526_AT1 and 528_AT2) or (51382_AT1 and 9296_AT1 and 534_AT1 and 245973_AT1 and 51606_AT2 and 529_AT1 and 523_AT1 and 526_AT1) or (51382_AT1 and 9296_AT1 and 127124_AT1 and 245973_AT1 and 90423_AT1 and 523_AT1 and 51606_AT1 and 526_AT1) or (51382_AT1 and 9296_AT1 and 127124_AT2 and 529_AT1 and 528_AT1 and 523_AT1 and 51606_AT1 and 526_AT1) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 127124_AT1 and 525_AT1 and 90423_AT1 and 528_AT1 and 523_AT1) or (51382_AT1 and 9296_AT1 and 245973_AT1 and 525_AT1 and 90423_AT1 and 9550_AT1 and 51606_AT2 and 523_AT1) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 90423_AT1 and 127124_AT2 and 523_AT1 and 526_AT1 and 528_AT2) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 245973_AT1 and 90423_AT1 and 127124_AT2 and 523_AT1 and 526_AT1) or (51382_AT1 and 9296_AT1 and 525_AT1 and 9550_AT1 and 51606_AT2 and 529_AT1 and 528_AT1 and 523_AT1) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 525_AT1 and 9550_AT1 and 529_AT1 and 528_AT1 and 523_AT1) or (51382_AT1 and 9296_AT1 and 534_AT1 and 525_AT1 and 90423_AT1 and 523_AT1 and 51606_AT1 and 528_AT2) or (51382_AT1 and 9296_AT1 and 127124_AT1 and 245973_AT1 and 525_AT1 and 51606_AT2 and 529_AT1 and 523_AT1) or (51382_AT1 and 9296_AT1 and 525_AT1 and 9550_AT1 and 51606_AT2 and 529_AT1 and 523_AT1 and 528_AT2) or (51382_AT1 and 9296_AT1 and 9550_AT1 and 51606_AT2 and 529_AT1 and 523_AT1 and 526_AT1 and 528_AT2) or (51382_AT1 and 9296_AT1 and 245973_AT1 and 525_AT1 and 9550_AT1 and 529_AT1 and 523_AT1 and 51606_AT1) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 534_AT1 and 245973_AT1 and 90423_AT1 and 523_AT1 and 526_AT1) or (51382_AT1 and 9296_AT1 and 245973_AT1 and 534_AT2 and 525_AT1 and 529_AT1 and 523_AT1 and 51606_AT1) or (51382_AT1 and 9296_AT1 and 525_AT1 and 90423_AT1 and 127124_AT2 and 51606_AT2 and 523_AT1 and 528_AT2) or (51382_AT1 and 9296_AT1 and 525_AT1 and 127124_AT2 and 529_AT1 and 528_AT1 and 523_AT1 and 51606_AT1) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 127124_AT1 and 245973_AT1 and 525_AT1 and 90423_AT1 and 523_AT1) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 525_AT1 and 127124_AT2 and 529_AT1 and 523_AT1 and 528_AT2) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 127124_AT1 and 90423_AT1 and 528_AT1 and 523_AT1 and 526_AT1) or (51382_AT1 and 9296_AT1 and 525_AT1 and 9550_AT1 and 529_AT1 and 523_AT1 and 51606_AT1 and 528_AT2) or (51382_AT1 and 9296_AT1 and 534_AT1 and 245973_AT1 and 525_AT1 and 90423_AT1 and 51606_AT2 and 523_AT1) or (51382_AT1 and 9296_AT1 and 127124_AT2 and 51606_AT2 and 529_AT1 and 528_AT1 and 523_AT1 and 526_AT1) or (51382_AT1 and 9296_AT1 and 245973_AT1 and 534_AT2 and 90423_AT1 and 51606_AT2 and 523_AT1 and 526_AT1) or (51382_AT1 and 9296_AT1 and 534_AT2 and 525_AT1 and 90423_AT1 and 51606_AT2 and 523_AT1 and 528_AT2) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 9550_AT1 and 529_AT1 and 523_AT1 and 526_AT1 and 528_AT2) or (51382_AT1 and 9296_AT1 and 534_AT2 and 525_AT1 and 90423_AT1 and 523_AT1 and 51606_AT1 and 528_AT2) or (51382_AT1 and 9296_AT1 and 534_AT1 and 525_AT1 and 51606_AT2 and 529_AT1 and 528_AT1 and 523_AT1) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 534_AT1 and 529_AT1 and 528_AT1 and 523_AT1 and 526_AT1) or (51382_AT1 and 9296_AT1 and 534_AT2 and 51606_AT2 and 529_AT1 and 528_AT1 and 523_AT1 and 526_AT1) or (51382_AT1 and 9296_AT1 and 127124_AT1 and 90423_AT1 and 528_AT1 and 523_AT1 and 51606_AT1 and 526_AT1) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 127124_AT1 and 529_AT1 and 523_AT1 and 526_AT1 and 528_AT2) or (51382_AT1 and 9296_AT1 and 534_AT1 and 245973_AT1 and 90423_AT1 and 523_AT1 and 51606_AT1 and 526_AT1) or (51382_AT1 and 9296_AT1 and 127124_AT1 and 90423_AT1 and 51606_AT2 and 523_AT1 and 526_AT1 and 528_AT2) or (51382_AT1 and 9296_AT1 and 534_AT2 and 529_AT1 and 523_AT1 and 51606_AT1 and 526_AT1 and 528_AT2) or (51382_AT1 and 9296_AT1 and 534_AT1 and 525_AT1 and 529_AT1 and 523_AT1 and 51606_AT1 and 528_AT2) or (51382_AT1 and 9296_AT1 and 245973_AT1 and 90423_AT1 and 9550_AT1 and 51606_AT2 and 523_AT1 and 526_AT1) or (51382_AT1 and 9296_AT1 and 127124_AT1 and 525_AT1 and 90423_AT1 and 528_AT1 and 523_AT1 and 51606_AT1) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 534_AT2 and 525_AT1 and 90423_AT1 and 523_AT1 and 528_AT2) or (51382_AT1 and 9296_AT1 and 127124_AT1 and 90423_AT1 and 523_AT1 and 51606_AT1 and 526_AT1 and 528_AT2) or (51382_AT1 and 9296_AT1 and 127124_AT1 and 525_AT1 and 529_AT1 and 528_AT1 and 523_AT1 and 51606_AT1) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 127124_AT1 and 245973_AT1 and 525_AT1 and 529_AT1 and 523_AT1) or (51382_AT1 and 9296_AT1 and 127124_AT1 and 51606_AT2 and 529_AT1 and 523_AT1 and 526_AT1 and 528_AT2) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 534_AT1 and 90423_AT1 and 523_AT1 and 526_AT1 and 528_AT2) or (51382_AT1 and 9296_AT1 and 525_AT1 and 90423_AT1 and 9550_AT1 and 51606_AT2 and 523_AT1 and 528_AT2) or (51382_AT1 and 9296_AT1 and 127124_AT1 and 51606_AT2 and 529_AT1 and 528_AT1 and 523_AT1 and 526_AT1) or (51382_AT1 and 9296_AT1 and 245973_AT1 and 534_AT2 and 529_AT1 and 523_AT1 and 51606_AT1 and 526_AT1) or (51382_AT1 and 9296_AT1 and 534_AT2 and 525_AT1 and 90423_AT1 and 528_AT1 and 523_AT1 and 51606_AT1) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 127124_AT1 and 245973_AT1 and 90423_AT1 and 523_AT1 and 526_AT1) or (51382_AT1 and 9296_AT1 and 245973_AT1 and 525_AT1 and 127124_AT2 and 51606_AT2 and 529_AT1 and 523_AT1) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 245973_AT1 and 525_AT1 and 9550_AT1 and 529_AT1 and 523_AT1) or (51382_AT1 and 9296_AT1 and 90423_AT1 and 127124_AT2 and 528_AT1 and 523_AT1 and 51606_AT1 and 526_AT1) or (51382_AT1 and 9296_AT1 and 9550_AT1 and 529_AT1 and 523_AT1 and 51606_AT1 and 526_AT1 and 528_AT2) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 534_AT1 and 525_AT1 and 529_AT1 and 523_AT1 and 528_AT2) or (51382_AT1 and 9296_AT1 and 534_AT1 and 245973_AT1 and 525_AT1 and 51606_AT2 and 529_AT1 and 523_AT1) or (51382_AT1 and 9296_AT1 and 90423_AT1 and 9550_AT1 and 528_AT1 and 523_AT1 and 51606_AT1 and 526_AT1) or (51382_AT1 and 9296_AT1 and 525_AT1 and 90423_AT1 and 9550_AT1 and 523_AT1 and 51606_AT1 and 528_AT2) or (51382_AT1 and 9296_AT1 and 534_AT1 and 90423_AT1 and 51606_AT2 and 528_AT1 and 523_AT1 and 526_AT1) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 245973_AT1 and 534_AT2 and 525_AT1 and 529_AT1 and 523_AT1) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 90423_AT1 and 127124_AT2 and 528_AT1 and 523_AT1 and 526_AT1) or (51382_AT1 and 9296_AT1 and 525_AT1 and 127124_AT2 and 529_AT1 and 523_AT1 and 51606_AT1 and 528_AT2) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 90423_AT1 and 9550_AT1 and 528_AT1 and 523_AT1 and 526_AT1) or (51382_AT1 and 9296_AT1 and 534_AT1 and 529_AT1 and 528_AT1 and 523_AT1 and 51606_AT1 and 526_AT1) or (51382_AT1 and 9296_AT1 and 9550_AT1 and 51606_AT2 and 529_AT1 and 528_AT1 and 523_AT1 and 526_AT1) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 534_AT2 and 525_AT1 and 529_AT1 and 528_AT1 and 523_AT1) or (51382_AT1 and 9296_AT1 and 127124_AT1 and 525_AT1 and 90423_AT1 and 523_AT1 and 51606_AT1 and 528_AT2) or (51382_AT1 and 9296_AT1 and 127124_AT1 and 245973_AT1 and 529_AT1 and 523_AT1 and 51606_AT1 and 526_AT1) or (51382_AT1 and 9296_AT1 and 534_AT2 and 90423_AT1 and 523_AT1 and 51606_AT1 and 526_AT1 and 528_AT2) or (51382_AT1 and 9296_AT1 and 534_AT1 and 245973_AT1 and 90423_AT1 and 51606_AT2 and 523_AT1 and 526_AT1) or (51382_AT1 and 9296_AT1 and 525_AT1 and 90423_AT1 and 9550_AT1 and 51606_AT2 and 528_AT1 and 523_AT1) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 245973_AT1 and 127124_AT2 and 529_AT1 and 523_AT1 and 526_AT1) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 245973_AT1 and 534_AT2 and 525_AT1 and 90423_AT1 and 523_AT1) or (51382_AT1 and 9296_AT1 and 534_AT1 and 529_AT1 and 523_AT1 and 51606_AT1 and 526_AT1 and 528_AT2) or (51382_AT1 and 9296_AT1 and 534_AT1 and 245973_AT1 and 525_AT1 and 90423_AT1 and 523_AT1 and 51606_AT1) or (51382_AT1 and 9296_AT1 and 245973_AT1 and 9550_AT1 and 51606_AT2 and 529_AT1 and 523_AT1 and 526_AT1) or (51382_AT1 and 9296_AT1 and 245973_AT1 and 534_AT2 and 525_AT1 and 90423_AT1 and 523_AT1 and 51606_AT1) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 245973_AT1 and 534_AT2 and 90423_AT1 and 523_AT1 and 526_AT1) or (51382_AT1 and 9296_AT1 and 525_AT1 and 90423_AT1 and 127124_AT2 and 51606_AT2 and 528_AT1 and 523_AT1) or (51382_AT1 and 9296_AT1 and 245973_AT1 and 534_AT2 and 51606_AT2 and 529_AT1 and 523_AT1 and 526_AT1) or (51382_AT1 and 9296_AT1 and 534_AT1 and 245973_AT1 and 525_AT1 and 529_AT1 and 523_AT1 and 51606_AT1) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 534_AT2 and 529_AT1 and 528_AT1 and 523_AT1 and 526_AT1) or (51382_AT1 and 9296_AT1 and 90423_AT1 and 9550_AT1 and 51606_AT2 and 523_AT1 and 526_AT1 and 528_AT2) or (51382_AT1 and 9296_AT1 and 534_AT2 and 90423_AT1 and 51606_AT2 and 528_AT1 and 523_AT1 and 526_AT1) or (51382_AT1 and 9296_AT1 and 534_AT1 and 525_AT1 and 90423_AT1 and 51606_AT2 and 523_AT1 and 528_AT2) or (51382_AT1 and 9296_AT1 and 534_AT2 and 525_AT1 and 90423_AT1 and 51606_AT2 and 528_AT1 and 523_AT1) or (51382_AT1 and 9296_AT1 and 525_AT1 and 90423_AT1 and 127124_AT2 and 528_AT1 and 523_AT1 and 51606_AT1) or (51382_AT1 and 9296_AT1 and 534_AT1 and 245973_AT1 and 529_AT1 and 523_AT1 and 51606_AT1 and 526_AT1) or (51382_AT1 and 9296_AT1 and 90423_AT1 and 9550_AT1 and 51606_AT2 and 528_AT1 and 523_AT1 and 526_AT1) or (51382_AT1 and 9296_AT1 and 127124_AT1 and 245973_AT1 and 90423_AT1 and 51606_AT2 and 523_AT1 and 526_AT1) or (51382_AT1 and 9296_AT1 and 525_AT1 and 90423_AT1 and 9550_AT1 and 528_AT1 and 523_AT1 and 51606_AT1) or (51382_AT1 and 9296_AT1 and 525_AT1 and 9550_AT1 and 529_AT1 and 528_AT1 and 523_AT1 and 51606_AT1) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 534_AT1 and 245973_AT1 and 525_AT1 and 529_AT1 and 523_AT1) or (51382_AT1 and 9296_AT1 and 245973_AT1 and 525_AT1 and 90423_AT1 and 9550_AT1 and 523_AT1 and 51606_AT1) or (51382_AT1 and 9296_AT1 and 127124_AT1 and 245973_AT1 and 525_AT1 and 529_AT1 and 523_AT1 and 51606_AT1) or (51382_AT1 and 9296_AT1 and 534_AT2 and 525_AT1 and 529_AT1 and 523_AT1 and 51606_AT1 and 528_AT2) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 534_AT2 and 529_AT1 and 523_AT1 and 526_AT1 and 528_AT2) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 525_AT1 and 90423_AT1 and 127124_AT2 and 523_AT1 and 528_AT2) or (51382_AT1 and 9296_AT1 and 534_AT1 and 90423_AT1 and 523_AT1 and 51606_AT1 and 526_AT1 and 528_AT2) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 245973_AT1 and 525_AT1 and 90423_AT1 and 127124_AT2 and 523_AT1) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 127124_AT1 and 525_AT1 and 90423_AT1 and 523_AT1 and 528_AT2) or (51382_AT1 and 9296_AT1 and 90423_AT1 and 127124_AT2 and 523_AT1 and 51606_AT1 and 526_AT1 and 528_AT2) or (51382_AT1 and 9296_AT1 and 534_AT1 and 525_AT1 and 90423_AT1 and 528_AT1 and 523_AT1 and 51606_AT1) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 245973_AT1 and 525_AT1 and 127124_AT2 and 529_AT1 and 523_AT1) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 525_AT1 and 9550_AT1 and 529_AT1 and 523_AT1 and 528_AT2) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 127124_AT2 and 529_AT1 and 523_AT1 and 526_AT1 and 528_AT2) or (51382_AT1 and 9296_AT1 and 245973_AT1 and 525_AT1 and 9550_AT1 and 51606_AT2 and 529_AT1 and 523_AT1) or (51382_AT1 and 9296_AT1 and 525_AT1 and 90423_AT1 and 127124_AT2 and 523_AT1 and 51606_AT1 and 528_AT2) or (51382_AT1 and 9296_AT1 and 245973_AT1 and 525_AT1 and 90423_AT1 and 127124_AT2 and 523_AT1 and 51606_AT1) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 127124_AT1 and 525_AT1 and 529_AT1 and 528_AT1 and 523_AT1) or (51382_AT1 and 9296_AT1 and 534_AT2 and 525_AT1 and 529_AT1 and 528_AT1 and 523_AT1 and 51606_AT1) or (51382_AT1 and 51606_AT3 and 9296_AT1 and 534_AT1 and 245973_AT1 and 529_AT1 and 523_AT1 and 526_AT1) or (51382_AT1 and 9296_AT1 and 525_AT1 and 127124_AT2 and 51606_AT2 and 529_AT1 and 528_AT1 and 523_AT1))"}, {"subsystem": "Transport, Mitochondrial", "name": "ATPtm", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ATPtm"]}, "metabolites": {"adp_m": 1.0, "atp_m": -1.0, "atp_c": 1.0, "adp_c": -1.0}, "id": "ATPtm", "gene_reaction_rule": "291_AT1 or 293_AT1 or 292_AT1"}, {"subsystem": "Transport, Nuclear", "name": "ATPtn", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["ATPtn"]}, "metabolites": {"atp_n": 1.0, "atp_c": -1.0}, "id": "ATPtn", "gene_reaction_rule": ""}, {"subsystem": "Transport, Peroxisomal", "name": "ATPtx", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["ATPtx"]}, "metabolites": {"atp_x": 1.0, "atp_c": -1.0}, "id": "ATPtx", "gene_reaction_rule": ""}, {"subsystem": "Transport, Extracellular", "name": "AVITE1t", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AVITE1t"]}, "metabolites": {"avite1_c": 1.0, "avite1_e": -1.0}, "id": "AVITE1t", "gene_reaction_rule": ""}, {"subsystem": "Transport, Extracellular", "name": "AVITE2t", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AVITE2t"]}, "metabolites": {"avite2_e": -1.0, "avite2_c": 1.0}, "id": "AVITE2t", "gene_reaction_rule": ""}, {"subsystem": "N-Glycan Degradation", "name": "A MANASE", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["A_MANASE"]}, "metabolites": {"m2mn_c": -1.0, "h2o_c": -2.0, "mn_c": 1.0, "man_c": 2.0}, "id": "A_MANASE", "gene_reaction_rule": "4123_AT1"}, {"subsystem": "N-Glycan Degradation", "name": "A MANASEly", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["A_MANASEly"]}, "metabolites": {"man_l": 2.0, "mn_l": 1.0, "h2o_l": -2.0, "m2mn_l": -1.0}, "id": "A_MANASEly", "gene_reaction_rule": "4125_AT1"}, {"subsystem": "Sphingolipid Metabolism", "name": "B3GALT3g", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["B3GALT3g"]}, "metabolites": {"h_g": 1.0, "udpacgal_g": -1.0, "thcrm_hs_g": -1.0, "udp_g": 1.0, "gbside_hs_g": 1.0}, "id": "B3GALT3g", "gene_reaction_rule": "8706_AT4 or 8706_AT1 or 8706_AT3 or 8706_AT2"}, {"subsystem": "Sphingolipid Metabolism", "name": "B3GALT41g", "upper_bound": 999999.0, "lower_bound": 0.0, 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"Keratan sulfate biosynthesis", "name": "G14T6g", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["G14T6g"]}, "metabolites": {"h_g": 1.0, "ksi_pre3_g": 1.0, "ksi_pre2_g": -1.0, "udp_g": 1.0, "udpgal_g": -1.0}, "id": "G14T6g", "gene_reaction_rule": "8703_AT1 or 2683_AT1 or 8704_AT2 or 8704_AT1 or 9334_AT1"}, {"subsystem": "Keratan sulfate biosynthesis", "name": "G14T7g", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["G14T7g"]}, "metabolites": {"h_g": 1.0, "udpgal_g": -1.0, "udp_g": 1.0, "ksi_pre5_g": -1.0, "ksi_pre6_g": 1.0}, "id": "G14T7g", "gene_reaction_rule": "8703_AT1 or 2683_AT1 or 8704_AT2 or 8704_AT1 or 9334_AT1"}, {"subsystem": "Keratan sulfate biosynthesis", "name": "G14T8g", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["G14T8g"]}, "metabolites": {"h_g": 1.0, "ksi_pre9_g": 1.0, "ksi_pre8_g": -1.0, "udpgal_g": -1.0, "udp_g": 1.0}, "id": "G14T8g", "gene_reaction_rule": "8703_AT1 or 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"id": "G16MT_L", "gene_reaction_rule": ""}, {"subsystem": "N-Glycan Biosynthesis", "name": "G16MT U", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["G16MT_U"]}, "metabolites": {"gdpmann_c": -1.0, "m1mpdol_U_c": -0.1, "gdp_c": 1.0, "h_c": 1.0, "m2mpdol_U_c": 0.1}, "id": "G16MT_U", "gene_reaction_rule": ""}, {"subsystem": "N-Glycan Biosynthesis", "name": "G1M6MASNB1terg", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["G1M6MASNB1terg"]}, "metabolites": {"g1m6masnB1_g": 1.0, "g1m6masnB1_r": -1.0}, "id": "G1M6MASNB1terg", "gene_reaction_rule": ""}, {"subsystem": "N-Glycan Biosynthesis", "name": "G1M7MASNBterg", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["G1M7MASNBterg"]}, "metabolites": {"g1m7masnB_g": 1.0, "g1m7masnB_r": -1.0}, "id": "G1M7MASNBterg", "gene_reaction_rule": ""}, {"subsystem": "N-Glycan Biosynthesis", "name": "G1M7MASNCterg", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": 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{"subsystem": "N-Glycan Biosynthesis", "name": "G3M8MASNterg", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["G3M8MASNterg"]}, "metabolites": {"g3m8masn_r": -1.0, "g3m8masn_g": 1.0}, "id": "G3M8MASNterg", "gene_reaction_rule": ""}, {"subsystem": "Glycerophospholipid Metabolism", "name": "G3PD1", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["G3PD1"]}, "metabolites": {"glyc3p_c": -1.0, "nadh_c": 1.0, "nad_c": -1.0, "dhap_c": 1.0, "h_c": 1.0}, "id": "G3PD1", "gene_reaction_rule": "2819_AT1"}, {"subsystem": "Glycolysis/Gluconeogenesis", "name": "G3PD2m", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["G3PD2m"]}, "metabolites": {"fad_m": -1.0, "glyc3p_c": -1.0, "dhap_c": 1.0, "fadh2_m": 1.0}, "id": "G3PD2m", "gene_reaction_rule": "2820_AT1"}, {"subsystem": "Arginine and Proline Metabolism", "name": "L glutamate 5 semialdehyde dehydratase reversible mitochondrial", "upper_bound": 999999.0, 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"ksi_deg38_l": -1.0}, "id": "GALASE14ly", "gene_reaction_rule": "(5476_AT1 and 2720_AT1 and 2588_AT1 and 4758_AT1) or (5476_AT1 and 2720_AT1)"}, {"subsystem": "Keratan sulfate degradation", "name": "GALASE15ly", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GALASE15ly"]}, "metabolites": {"ksi_deg40_l": -1.0, "gal_l": 1.0, "ksi_deg41_l": 1.0, "h2o_l": -1.0}, "id": "GALASE15ly", "gene_reaction_rule": "(5476_AT1 and 2720_AT1 and 2588_AT1 and 4758_AT1) or (5476_AT1 and 2720_AT1)"}, {"subsystem": "Keratan sulfate degradation", "name": "GALASE16ly", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GALASE16ly"]}, "metabolites": {"ksii_core2_deg3_l": 1.0, "gal_l": 2.0, "ksii_core2_deg2_l": -1.0, "h2o_l": -2.0}, "id": "GALASE16ly", "gene_reaction_rule": "(5476_AT1 and 2720_AT1 and 2588_AT1 and 4758_AT1) or (5476_AT1 and 2720_AT1)"}, {"subsystem": "Keratan sulfate degradation", "name": "GALASE17ly", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GALASE17ly"]}, "metabolites": {"ksii_core2_deg6_l": 1.0, "gal_l": 1.0, "h2o_l": -1.0, "ksii_core2_deg5_l": -1.0}, "id": "GALASE17ly", "gene_reaction_rule": "(5476_AT1 and 2720_AT1 and 2588_AT1 and 4758_AT1) or (5476_AT1 and 2720_AT1)"}, {"subsystem": "Keratan sulfate degradation", "name": "GALASE18ly", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GALASE18ly"]}, "metabolites": {"ksii_core2_deg9_l": 1.0, "ksii_core2_deg8_l": -1.0, "gal_l": 1.0, "h2o_l": -1.0}, "id": "GALASE18ly", "gene_reaction_rule": "(5476_AT1 and 2720_AT1 and 2588_AT1 and 4758_AT1) or (5476_AT1 and 2720_AT1)"}, {"subsystem": "Keratan sulfate degradation", "name": "GALASE19ly", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GALASE19ly"]}, "metabolites": {"gal_l": 1.0, "f1a_l": -1.0, "h2o_l": -1.0, "core6_l": 1.0}, "id": "GALASE19ly", "gene_reaction_rule": "(5476_AT1 and 2720_AT1 and 2588_AT1 and 4758_AT1) or (5476_AT1 and 2720_AT1)"}, {"subsystem": "N-Glycan Degradation", "name": "GALASE1ly", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GALASE1ly"]}, "metabolites": {"l2n2m2mn_l": -1.0, "gal_l": 2.0, "h2o_l": -2.0, "n2m2mn_l": 1.0}, "id": "GALASE1ly", "gene_reaction_rule": "(5476_AT1 and 2720_AT1 and 2588_AT1 and 4758_AT1) or (5476_AT1 and 2720_AT1)"}, {"subsystem": "Keratan sulfate degradation", "name": "GALASE20ly", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GALASE20ly"]}, "metabolites": {"gal_l": 2.0, "h2o_l": -2.0, "ksii_core4_deg3_l": 1.0, "ksii_core4_deg2_l": -1.0}, "id": "GALASE20ly", "gene_reaction_rule": "(5476_AT1 and 2720_AT1 and 2588_AT1 and 4758_AT1) or (5476_AT1 and 2720_AT1)"}, {"subsystem": "Keratan sulfate degradation", "name": "GALASE3ly", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GALASE3ly"]}, "metabolites": {"ksi_deg5_l": -1.0, "gal_l": 2.0, "h2o_l": -2.0, "ksi_deg6_l": 1.0}, "id": "GALASE3ly", "gene_reaction_rule": "(5476_AT1 and 2720_AT1 and 2588_AT1 and 4758_AT1) or (5476_AT1 and 2720_AT1)"}, {"subsystem": "Keratan sulfate degradation", "name": "GALASE4ly", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GALASE4ly"]}, "metabolites": {"gal_l": 1.0, "ksi_deg9_l": 1.0, "ksi_deg8_l": -1.0, "h2o_l": -1.0}, "id": "GALASE4ly", "gene_reaction_rule": "(5476_AT1 and 2720_AT1 and 2588_AT1 and 4758_AT1) or (5476_AT1 and 2720_AT1)"}, {"subsystem": "Keratan sulfate degradation", "name": "GALASE5ly", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GALASE5ly"]}, "metabolites": {"ksi_deg11_l": -1.0, "gal_l": 1.0, "ksi_deg12_l": 1.0, "h2o_l": -1.0}, "id": "GALASE5ly", "gene_reaction_rule": "(5476_AT1 and 2720_AT1 and 2588_AT1 and 4758_AT1) or (5476_AT1 and 2720_AT1)"}, {"subsystem": "Keratan sulfate degradation", "name": "GALASE6ly", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GALASE6ly"]}, "metabolites": {"gal_l": 1.0, "h2o_l": -1.0, "ksi_deg15_l": 1.0, "ksi_deg14_l": -1.0}, "id": "GALASE6ly", "gene_reaction_rule": "(5476_AT1 and 2720_AT1 and 2588_AT1 and 4758_AT1) or (5476_AT1 and 2720_AT1)"}, {"subsystem": "Keratan sulfate degradation", "name": "GALASE7ly", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GALASE7ly"]}, "metabolites": {"ksi_deg17_l": -1.0, "ksi_deg18_l": 1.0, "gal_l": 1.0, "h2o_l": -1.0}, "id": "GALASE7ly", "gene_reaction_rule": "(5476_AT1 and 2720_AT1 and 2588_AT1 and 4758_AT1) or (5476_AT1 and 2720_AT1)"}, {"subsystem": "Keratan sulfate degradation", "name": "GALASE8ly", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GALASE8ly"]}, "metabolites": {"ksi_deg20_l": -1.0, "ksi_deg21_l": 1.0, "gal_l": 1.0, "h2o_l": -1.0}, "id": "GALASE8ly", "gene_reaction_rule": "(5476_AT1 and 2720_AT1 and 2588_AT1 and 4758_AT1) or (5476_AT1 and 2720_AT1)"}, {"subsystem": "Keratan sulfate degradation", "name": "GALASE9ly", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GALASE9ly"]}, "metabolites": {"gal_l": 1.0, "h2o_l": -1.0, "ksi_deg24_l": 1.0, "ksi_deg23_l": -1.0}, "id": "GALASE9ly", "gene_reaction_rule": "(5476_AT1 and 2720_AT1 and 2588_AT1 and 4758_AT1) or (5476_AT1 and 2720_AT1)"}, {"subsystem": "Sphingolipid Metabolism", "name": "GALC", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GALC"]}, "metabolites": {"crm_hs_l": 1.0, "gal_l": 1.0, "h2o_l": -1.0, "galside_hs_l": -1.0}, "id": "GALC", "gene_reaction_rule": "2581_AT1"}, {"subsystem": "Transport, Extracellular", "name": "GALFUC12GAL14ACGLCGALGLUSIDEte", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["GALFUC12GAL14ACGLCGALGLUSIDEte"]}, "metabolites": {"galfuc12gal14acglcgalgluside_hs_c": 1.0, "galfuc12gal14acglcgalgluside_hs_e": -1.0}, "id": "GALFUC12GAL14ACGLCGALGLUSIDEte", "gene_reaction_rule": ""}, {"subsystem": "Transport, Golgi Apparatus", "name": "GALFUC12GAL14ACGLCGALGLUSIDEtg", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["GALFUC12GAL14ACGLCGALGLUSIDEtg"]}, "metabolites": {"galfuc12gal14acglcgalgluside_hs_c": 1.0, "galfuc12gal14acglcgalgluside_hs_g": -1.0}, "id": "GALFUC12GAL14ACGLCGALGLUSIDEtg", "gene_reaction_rule": ""}, {"subsystem": "Transport, Extracellular", "name": "GALFUCGALACGLCGAL14ACGLCGALGLUSIDEte", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["GALFUCGALACGLCGAL14ACGLCGALGLUSIDEte"]}, "metabolites": {"galfucgalacglcgal14acglcgalgluside_hs_e": -1.0, "galfucgalacglcgal14acglcgalgluside_hs_c": 1.0}, "id": "GALFUCGALACGLCGAL14ACGLCGALGLUSIDEte", "gene_reaction_rule": ""}, {"subsystem": "Transport, Golgi Apparatus", "name": "GALFUCGALACGLCGAL14ACGLCGALGLUSIDEtg", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["GALFUCGALACGLCGAL14ACGLCGALGLUSIDEtg"]}, "metabolites": {"galfucgalacglcgal14acglcgalgluside_hs_g": -1.0, "galfucgalacglcgal14acglcgalgluside_hs_c": 1.0}, "id": "GALFUCGALACGLCGAL14ACGLCGALGLUSIDEtg", "gene_reaction_rule": ""}, {"subsystem": "Transport, Extracellular", "name": "GALGALFUCFUCGALACGLCGALACGLCGAL14ACGLCGALGLUSIDEte", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["GALGALFUCFUCGALACGLCGALACGLCGAL14ACGLCGALGLUSIDEte"]}, "metabolites": {"galgalfucfucgalacglcgalacglcgal14acglcgalgluside_hs_c": 1.0, "galgalfucfucgalacglcgalacglcgal14acglcgalgluside_hs_e": -1.0}, "id": "GALGALFUCFUCGALACGLCGALACGLCGAL14ACGLCGALGLUSIDEte", "gene_reaction_rule": ""}, {"subsystem": "Transport, Golgi Apparatus", "name": "GALGALFUCFUCGALACGLCGALACGLCGAL14ACGLCGALGLUSIDEtg", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["GALGALFUCFUCGALACGLCGALACGLCGAL14ACGLCGALGLUSIDEtg"]}, "metabolites": {"galgalfucfucgalacglcgalacglcgal14acglcgalgluside_hs_c": 1.0, "galgalfucfucgalacglcgalacglcgal14acglcgalgluside_hs_g": -1.0}, "id": "GALGALFUCFUCGALACGLCGALACGLCGAL14ACGLCGALGLUSIDEtg", "gene_reaction_rule": ""}, {"subsystem": "Transport, Extracellular", "name": "GALGALGALTHCRMte", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["GALGALGALTHCRMte"]}, "metabolites": {"galgalgalthcrm_hs_c": -1.0, "galgalgalthcrm_hs_e": 1.0}, "id": "GALGALGALTHCRMte", "gene_reaction_rule": ""}, {"subsystem": "Transport, Golgi Apparatus", "name": "GALGALGALTHCRMtg", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["GALGALGALTHCRMtg"]}, "metabolites": {"galgalgalthcrm_hs_c": -1.0, "galgalgalthcrm_hs_g": 1.0}, "id": "GALGALGALTHCRMtg", "gene_reaction_rule": ""}, {"subsystem": "Transport, Golgi Apparatus", "name": "GALGLUSIDEtg", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["GALGLUSIDEtg"]}, "metabolites": {"galgluside_hs_g": 1.0, "galgluside_hs_c": -1.0}, "id": "GALGLUSIDEtg", "gene_reaction_rule": ""}, {"subsystem": "Transport, Lysosomal", "name": "GALGLUSIDEtl", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["GALGLUSIDEtl"]}, "metabolites": {"galgluside_hs_l": 1.0, "galgluside_hs_c": -1.0}, "id": "GALGLUSIDEtl", "gene_reaction_rule": ""}, {"subsystem": "Sphingolipid Metabolism", "name": "GALGT1", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GALGT1"]}, "metabolites": {"ga2_hs_g": 1.0, "galgluside_hs_g": -1.0, "udpacgal_g": -1.0, "udp_g": 1.0, "h_g": 1.0}, "id": "GALGT1", "gene_reaction_rule": "2583_AT1"}, {"subsystem": "Sphingolipid Metabolism", "name": "GALGT2", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GALGT2"]}, "metabolites": {"h_g": 1.0, "udpacgal_g": -1.0, "gm2_hs_g": 1.0, "udp_g": 1.0, "gm3_hs_g": -1.0}, "id": "GALGT2", "gene_reaction_rule": "2583_AT1"}, {"subsystem": "Sphingolipid Metabolism", "name": "GALGT3", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GALGT3"]}, "metabolites": {"h_g": 1.0, "udpacgal_g": -1.0, "gd3_hs_g": -1.0, "udp_g": 1.0, "gd2_hs_g": 1.0}, "id": "GALGT3", "gene_reaction_rule": "2583_AT1"}, {"subsystem": "Sphingolipid Metabolism", "name": "GALGT4", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GALGT4"]}, "metabolites": {"gt2_hs_g": 1.0, "udpacgal_g": -1.0, "gt3_hs_g": -1.0, "udp_g": 1.0, "h_g": 1.0}, "id": "GALGT4", "gene_reaction_rule": "2583_AT1"}, {"subsystem": "Galactose metabolism", "name": "Galactokinase", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GALK"]}, "metabolites": {"adp_c": 1.0, "gal_c": -1.0, "h_c": 1.0, "atp_c": -1.0, "gal1p_c": 1.0}, "id": "GALKr", "gene_reaction_rule": "2584_AT1 or 2585_AT2 or 2585_AT1"}, {"subsystem": "Chondroitin / heparan sulfate biosynthesis", "name": "GALNACT1g", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GALNACT1g"]}, "metabolites": {"h_g": 1.0, "udpacgal_g": -1.0, "cs_hs_linkage_g": -1.0, "udp_g": 1.0, "cs_pre_g": 1.0}, "id": "GALNACT1g", "gene_reaction_rule": "55790_AT1 or 55454_AT1"}, {"subsystem": "Chondroitin / heparan sulfate biosynthesis", "name": "GALNACT2g", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GALNACT2g"]}, "metabolites": {"cs_a_b_pre2_g": -1.0, "uacgam_g": -1.0, "cs_a_b_pre3_g": 1.0, "udp_g": 1.0, "h_g": 1.0}, "id": "GALNACT2g", "gene_reaction_rule": "55790_AT1 or (79586_AT1 and 22856_AT1) or 55454_AT1 or 337876_AT1"}, {"subsystem": "Chondroitin / heparan sulfate biosynthesis", "name": "GALNACT3g", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GALNACT3g"]}, "metabolites": {"h_g": 1.0, "uacgam_g": -1.0, "cs_c_pre3_g": 1.0, "cs_c_pre2_g": -1.0, "udp_g": 1.0}, "id": "GALNACT3g", "gene_reaction_rule": "55790_AT1 or (79586_AT1 and 22856_AT1) or 55454_AT1 or 337876_AT1"}, {"subsystem": "Chondroitin / heparan sulfate biosynthesis", "name": "GALNACT4g", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GALNACT4g"]}, "metabolites": {"udp_g": 1.0, "h_g": 1.0, "uacgam_g": -1.0, "cs_d_pre3_g": -1.0, "cs_d_pre4_g": 1.0}, "id": "GALNACT4g", "gene_reaction_rule": "55790_AT1 or (79586_AT1 and 22856_AT1) or 55454_AT1 or 337876_AT1"}, {"subsystem": "Chondroitin / heparan sulfate biosynthesis", "name": "GALNACT5g", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GALNACT5g"]}, "metabolites": {"udp_g": 1.0, "h_g": 1.0, "uacgam_g": -1.0, "cs_e_pre4_g": 1.0, "cs_e_pre3_g": -1.0}, "id": "GALNACT5g", "gene_reaction_rule": "55454_AT1 or 55790_AT1 or 337876_AT1 or (79586_AT1 and 22856_AT1)"}, {"subsystem": "O-Glycan Biosynthesis", "name": "GALNTg", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GALNTg"]}, "metabolites": {"h_g": 1.0, "Ser_Thr_g": -1.0, "udpacgal_g": -1.0, "udp_g": 1.0, "Tn_antigen_g": 1.0}, "id": "GALNTg", "gene_reaction_rule": "79695_AT1 or 50614_AT1 or 55568_AT2 or 11226_AT1 or 2590_AT1 or 26290_AT1 or 79623_AT1 or 26290_AT1 or 2589_AT1 or 8693_AT1 or 114805_AT1 or 11227_AT1 or 117248_AT1 or 55568_AT1 or 51809_AT1 or 63917_AT1 or 2591_AT1"}, {"subsystem": "Galactose metabolism", "name": "GALOR", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["GALOR"]}, "metabolites": {"galt_c": 1.0, "gal_c": -1.0, "nadph_c": -1.0, "h_c": -1.0, "nadp_c": 1.0}, "id": "GALOR", "gene_reaction_rule": "231_AT1 or 10327_AT2 or 10327_AT1"}, {"subsystem": "Transport, Golgi Apparatus", "name": "GALSIDEtg", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["GALSIDEtg"]}, "metabolites": {"galside_hs_c": -1.0, "galside_hs_g": 1.0}, "id": "GALSIDEtg", "gene_reaction_rule": ""}, {"subsystem": "Transport, Lysosomal", "name": "GALSIDEtl", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["GALSIDEtl"]}, 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{"subsystem": "Transport, Golgi Apparatus", "name": "GQ1BALPHAtg", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["GQ1BALPHAtg"]}, "metabolites": {"gq1balpha_hs_g": 1.0, "gq1balpha_hs_c": -1.0}, "id": "GQ1BALPHAtg", "gene_reaction_rule": ""}, {"subsystem": "Transport, Extracellular", "name": "GQ1Bte", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["GQ1Bte"]}, "metabolites": {"gq1b_hs_c": -1.0, "gq1b_hs_e": 1.0}, "id": "GQ1Bte", "gene_reaction_rule": ""}, {"subsystem": "Transport, Golgi Apparatus", "name": "GQ1Btg", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["GQ1Btg"]}, "metabolites": {"gq1b_hs_c": -1.0, "gq1b_hs_g": 1.0}, "id": "GQ1Btg", "gene_reaction_rule": ""}, {"subsystem": "Cholesterol Metabolism", "name": "Geranyltranstransferase", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GRTT"]}, "metabolites": {"ppi_c": 1.0, "ipdp_c": -1.0, 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"notes": {"original_bigg_ids": ["NACHEX27ly"]}, "metabolites": {"ha_deg1_l": -1.0, "ha_pre1_l": 1.0, "h2o_l": -1.0, "acgam_l": 1.0}, "id": "NACHEX27ly", "gene_reaction_rule": "(3073_AT1 and 3074_AT1) or 3073_AT1 or 3074_AT1"}, {"subsystem": "Chondroitin sulfate degradation", "name": "NACHEX2ly", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NACHEX2ly"]}, "metabolites": {"cs_a_deg5_l": 1.0, "cs_a_deg4_l": -1.0, "h2o_l": -1.0, "acgal_l": 1.0}, "id": "NACHEX2ly", "gene_reaction_rule": "(3073_AT1 and 3074_AT1) or 3073_AT1 or 3074_AT1"}, {"subsystem": "Chondroitin sulfate degradation", "name": "NACHEX3ly", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NACHEX3ly"]}, "metabolites": {"cs_b_deg1_l": -1.0, "cs_b_deg2_l": 1.0, "h2o_l": -1.0, "acgal_l": 1.0}, "id": "NACHEX3ly", "gene_reaction_rule": "(3073_AT1 and 3074_AT1) or 3074_AT1 or 3073_AT1"}, {"subsystem": "Chondroitin sulfate degradation", "name": "NACHEX4ly", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NACHEX4ly"]}, "metabolites": {"cs_c_deg1_l": -1.0, "h2o_l": -1.0, "acgal_l": 1.0, "cs_c_deg2_l": 1.0}, "id": "NACHEX4ly", "gene_reaction_rule": "(3073_AT1 and 3074_AT1) or 3074_AT1 or 3073_AT1"}, {"subsystem": "Chondroitin sulfate degradation", "name": "NACHEX5ly", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NACHEX5ly"]}, "metabolites": {"cs_c_deg5_l": 1.0, "cs_c_deg4_l": -1.0, "acgal_l": 1.0, "h2o_l": -1.0}, "id": "NACHEX5ly", "gene_reaction_rule": "(3073_AT1 and 3074_AT1) or 3074_AT1 or 3073_AT1"}, {"subsystem": "Chondroitin sulfate degradation", "name": "NACHEX6ly", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NACHEX6ly"]}, "metabolites": {"cs_d_deg2_l": 1.0, "h2o_l": -1.0, "acgal_l": 1.0, "cs_d_deg1_l": -1.0}, "id": "NACHEX6ly", "gene_reaction_rule": "(3073_AT1 and 3074_AT1) or 3074_AT1 or 3073_AT1"}, {"subsystem": "Chondroitin sulfate degradation", "name": "NACHEX7ly", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NACHEX7ly"]}, "metabolites": {"cs_d_deg6_l": 1.0, "cs_d_deg5_l": -1.0, "h2o_l": -1.0, "acgal_l": 1.0}, "id": "NACHEX7ly", "gene_reaction_rule": "(3073_AT1 and 3074_AT1) or 3074_AT1 or 3073_AT1"}, {"subsystem": "Chondroitin sulfate degradation", "name": "NACHEX8ly", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NACHEX8ly"]}, "metabolites": {"cs_e_deg3_l": 1.0, "h2o_l": -1.0, "acgal_l": 1.0, "cs_e_deg2_l": -1.0}, "id": "NACHEX8ly", "gene_reaction_rule": "(3073_AT1 and 3074_AT1) or 3074_AT1 or 3073_AT1"}, {"subsystem": "Chondroitin sulfate degradation", "name": "NACHEX9ly", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NACHEX9ly"]}, "metabolites": {"cs_e_deg7_l": 1.0, "cs_e_deg6_l": -1.0, "h2o_l": -1.0, "acgal_l": 1.0}, "id": "NACHEX9ly", "gene_reaction_rule": "(3073_AT1 and 3074_AT1) or 3073_AT1 or 3074_AT1"}, {"subsystem": "Keratan sulfate degradation", "name": "NACHEXA10ly", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NACHEXA10ly"]}, "metabolites": {"h2o_l": -2.0, "acgam_l": 1.0, "ksi_deg9_l": -1.0, "ksi_deg11_l": 1.0, "h_l": 1.0, "so4_l": 1.0}, "id": "NACHEXA10ly", "gene_reaction_rule": "3073_AT1 or (3073_AT1 and 3074_AT1)"}, {"subsystem": "Keratan sulfate degradation", "name": "NACHEXA11ly", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NACHEXA11ly"]}, "metabolites": {"ksi_deg12_l": -1.0, "h2o_l": -2.0, "acgam_l": 1.0, "ksi_deg14_l": 1.0, "h_l": 1.0, "so4_l": 1.0}, "id": "NACHEXA11ly", "gene_reaction_rule": "(3073_AT1 and 3074_AT1) or 3073_AT1"}, {"subsystem": "Keratan sulfate degradation", "name": "NACHEXA12ly", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NACHEXA12ly"]}, "metabolites": {"ksi_deg17_l": 1.0, "h2o_l": -2.0, "acgam_l": 1.0, "so4_l": 1.0, "h_l": 1.0, "ksi_deg15_l": -1.0}, "id": "NACHEXA12ly", "gene_reaction_rule": "(3073_AT1 and 3074_AT1) or 3073_AT1"}, {"subsystem": "Keratan sulfate degradation", "name": "NACHEXA13ly", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NACHEXA13ly"]}, "metabolites": {"ksi_deg20_l": 1.0, "ksi_deg18_l": -1.0, "h2o_l": -2.0, "acgam_l": 1.0, "h_l": 1.0, "so4_l": 1.0}, "id": "NACHEXA13ly", "gene_reaction_rule": "(3073_AT1 and 3074_AT1) or 3073_AT1"}, {"subsystem": "Keratan sulfate degradation", "name": "NACHEXA14ly", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NACHEXA14ly"]}, "metabolites": {"ksi_deg23_l": 1.0, "h2o_l": -2.0, "acgam_l": 1.0, "h_l": 1.0, "ksi_deg21_l": -1.0, "so4_l": 1.0}, "id": "NACHEXA14ly", "gene_reaction_rule": "(3073_AT1 and 3074_AT1) or 3073_AT1"}, {"subsystem": "Keratan sulfate degradation", "name": "NACHEXA15ly", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NACHEXA15ly"]}, "metabolites": {"ksi_deg24_l": -1.0, "ksi_deg26_l": 1.0, "h2o_l": -2.0, "acgam_l": 1.0, "h_l": 1.0, "so4_l": 1.0}, "id": "NACHEXA15ly", "gene_reaction_rule": "(3073_AT1 and 3074_AT1) or 3073_AT1"}, {"subsystem": "Keratan sulfate degradation", "name": "NACHEXA16ly", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NACHEXA16ly"]}, "metabolites": {"ksi_deg27_l": -1.0, "ksi_deg29_l": 1.0, "h2o_l": -2.0, "acgam_l": 1.0, "h_l": 1.0, "so4_l": 1.0}, "id": "NACHEXA16ly", "gene_reaction_rule": "(3073_AT1 and 3074_AT1) or 3073_AT1"}, {"subsystem": "Keratan sulfate degradation", "name": "NACHEXA17ly", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NACHEXA17ly"]}, "metabolites": {"h2o_l": -2.0, "ksi_deg30_l": -1.0, "acgam_l": 1.0, "h_l": 1.0, "ksi_deg32_l": 1.0, "so4_l": 1.0}, "id": "NACHEXA17ly", "gene_reaction_rule": "(3073_AT1 and 3074_AT1) or 3073_AT1"}, {"subsystem": "Keratan sulfate degradation", "name": "NACHEXA18ly", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NACHEXA18ly"]}, "metabolites": {"ksi_deg33_l": -1.0, "ksi_deg35_l": 1.0, "h2o_l": -2.0, "acgam_l": 1.0, "h_l": 1.0, "so4_l": 1.0}, "id": "NACHEXA18ly", "gene_reaction_rule": "(3073_AT1 and 3074_AT1) or 3073_AT1"}, {"subsystem": "Keratan sulfate degradation", "name": "NACHEXA19ly", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NACHEXA19ly"]}, "metabolites": {"h2o_l": -2.0, "acgam_l": 1.0, "ksi_deg38_l": 1.0, "h_l": 1.0, "so4_l": 1.0, "ksi_deg36_l": -1.0}, "id": "NACHEXA19ly", "gene_reaction_rule": "(3073_AT1 and 3074_AT1) or 3073_AT1"}, {"subsystem": "Chondroitin sulfate degradation", "name": "NACHEXA1ly", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NACHEXA1ly"]}, "metabolites": {"cs_a_deg2_l": 1.0, "acgal_l": 1.0, "h2o_l": -2.0, "cs_a_l": -1.0, "h_l": 1.0, "so4_l": 1.0}, "id": "NACHEXA1ly", "gene_reaction_rule": "(3073_AT1 and 3074_AT1) or 3073_AT1"}, {"subsystem": "Keratan sulfate degradation", "name": "NACHEXA20ly", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NACHEXA20ly"]}, "metabolites": {"ksii_core2_deg5_l": 1.0, "h2o_l": -2.0, "acgam_l": 1.0, "ksii_core2_deg3_l": -1.0, "h_l": 1.0, "so4_l": 1.0}, "id": "NACHEXA20ly", "gene_reaction_rule": "(3073_AT1 and 3074_AT1) or 3073_AT1"}, {"subsystem": "Keratan sulfate degradation", "name": "NACHEXA21ly", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NACHEXA21ly"]}, "metabolites": {"h2o_l": -2.0, "acgam_l": 1.0, "ksii_core2_deg6_l": -1.0, "h_l": 1.0, "ksii_core2_deg8_l": 1.0, "so4_l": 1.0}, "id": "NACHEXA21ly", "gene_reaction_rule": "(3073_AT1 and 3074_AT1) or 3073_AT1"}, {"subsystem": "Keratan sulfate degradation", "name": "NACHEXA22ly", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NACHEXA22ly"]}, "metabolites": {"ksii_core2_deg5_l": 1.0, "h2o_l": -3.0, "ksii_core4_deg3_l": -1.0, "acgam_l": 2.0, "h_l": 1.0, "so4_l": 1.0}, "id": "NACHEXA22ly", "gene_reaction_rule": "(3073_AT1 and 3074_AT1) or 3073_AT1"}, {"subsystem": "Chondroitin sulfate degradation", "name": "NACHEXA2ly", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NACHEXA2ly"]}, "metabolites": {"cs_b_deg2_l": 1.0, "acgal_l": 1.0, "h2o_l": -2.0, "cs_b_l": -1.0, "h_l": 1.0, "so4_l": 1.0}, "id": "NACHEXA2ly", "gene_reaction_rule": "(3073_AT1 and 3074_AT1) or 3073_AT1"}, {"subsystem": "Chondroitin sulfate degradation", "name": "NACHEXA3ly", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NACHEXA3ly"]}, "metabolites": {"acgal_l": 1.0, "cs_c_l": -1.0, "h2o_l": -2.0, "cs_c_deg2_l": 1.0, "h_l": 1.0, "so4_l": 1.0}, "id": "NACHEXA3ly", "gene_reaction_rule": "(3073_AT1 and 3074_AT1) or 3073_AT1"}, {"subsystem": "Chondroitin sulfate degradation", "name": "NACHEXA4ly", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NACHEXA4ly"]}, "metabolites": {"acgal_l": 1.0, "cs_c_deg5_l": 1.0, "h2o_l": -2.0, "cs_c_deg3_l": -1.0, "h_l": 1.0, "so4_l": 1.0}, "id": "NACHEXA4ly", "gene_reaction_rule": "(3073_AT1 and 3074_AT1) or 3073_AT1"}, {"subsystem": "Chondroitin sulfate degradation", "name": "NACHEXA5ly", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NACHEXA5ly"]}, "metabolites": {"cs_d_l": -1.0, "acgal_l": 1.0, "cs_d_deg2_l": 1.0, "h2o_l": -2.0, "h_l": 1.0, "so4_l": 1.0}, "id": "NACHEXA5ly", "gene_reaction_rule": "(3073_AT1 and 3074_AT1) or 3073_AT1"}, {"subsystem": "Chondroitin sulfate degradation", "name": "NACHEXA6ly", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NACHEXA6ly"]}, "metabolites": {"acgal_l": 1.0, "h2o_l": -2.0, "cs_d_deg6_l": 1.0, "cs_d_deg4_l": -1.0, "h_l": 1.0, "so4_l": 1.0}, "id": "NACHEXA6ly", "gene_reaction_rule": "(3073_AT1 and 3074_AT1) or 3073_AT1"}, {"subsystem": "Chondroitin sulfate degradation", "name": "NACHEXA7ly", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NACHEXA7ly"]}, "metabolites": {"cs_e_deg3_l": 1.0, "acgal_l": 1.0, "h2o_l": -3.0, "h_l": 2.0, "cs_e_l": -1.0, "so4_l": 2.0}, "id": "NACHEXA7ly", "gene_reaction_rule": "(3073_AT1 and 3074_AT1) or 3073_AT1"}, {"subsystem": "Chondroitin sulfate degradation", "name": "NACHEXA8ly", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NACHEXA8ly"]}, "metabolites": {"acgal_l": 1.0, "h2o_l": -3.0, "cs_e_deg4_l": -1.0, "cs_e_deg7_l": 1.0, "h_l": 2.0, "so4_l": 2.0}, "id": "NACHEXA8ly", "gene_reaction_rule": "(3073_AT1 and 3074_AT1) or 3073_AT1"}, {"subsystem": "Keratan sulfate degradation", "name": "NACHEXA9ly", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NACHEXA9ly"]}, "metabolites": {"ksi_deg6_l": -1.0, "h2o_l": -3.0, "acgam_l": 2.0, "h_l": 1.0, "ksi_deg8_l": 1.0, "so4_l": 1.0}, "id": "NACHEXA9ly", "gene_reaction_rule": "(3073_AT1 and 3074_AT1) or 3073_AT1"}, {"subsystem": "Transport, Extracellular", "name": "Nicotinic acid transport", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NACUP"]}, "metabolites": {"nac_e": -1.0, "nac_c": 1.0}, "id": "NACt", "gene_reaction_rule": ""}, {"subsystem": "Oxidative Phosphorylation", "name": "NADH2 u10m", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADH2_u10m"]}, "metabolites": {"q10h2_m": 1.0, "h_c": 4.0, "nad_m": 1.0, "q10_m": -1.0, "h_m": -5.0, "nadh_m": -1.0}, "id": "NADH2_u10m", "gene_reaction_rule": "(4715_AT1 and 4720_AT1 and 4719_AT1 and 4700_AT1 and 55967_AT1 and 4709_AT1 and 4710_AT1 and 4726_AT1 and 4718_AT1 and 4696_AT1 and 4694_AT1 and 374291_AT1 and 4728_AT1 and 4712_AT2 and 4717_AT1 and 4705_AT1 and 4725_AT1 and 4716_AT1 and 4537_AT1 and 7991_AT1 and 4722_AT1 and 4541_AT1 and 4539_AT1 and 4707_AT1 and 4701_AT1 and 4723_AT1 and 4698_AT1 and 4538_AT1 and 4697_AT1 and 51079_AT1 and 4714_AT1 and 4704_AT1 and 126328_AT1 and 4711_AT1 and 4724_AT1 and 4713_AT1 and 4536_AT1 and 4695_AT1 and 4702_AT1 and 4708_AT1 and 4535_AT1 and 4731_AT2 and 4706_AT1 and 4729_AT1 and 4540_AT1) or (4715_AT1 and 4720_AT1 and 4719_AT1 and 55967_AT1 and 4700_AT1 and 4709_AT1 and 4710_AT1 and 4726_AT1 and 4696_AT1 and 4718_AT1 and 4694_AT1 and 374291_AT1 and 4728_AT1 and 7991_AT2 and 4717_AT1 and 4731_AT1 and 4705_AT1 and 4725_AT1 and 4716_AT1 and 4537_AT1 and 4722_AT1 and 4541_AT1 and 4712_AT1 and 4539_AT1 and 4707_AT1 and 4701_AT1 and 4698_AT1 and 4723_AT1 and 4538_AT1 and 4697_AT1 and 51079_AT1 and 4714_AT1 and 4704_AT1 and 126328_AT1 and 4711_AT1 and 4724_AT1 and 4536_AT1 and 4713_AT1 and 4695_AT1 and 4702_AT1 and 4708_AT1 and 4706_AT1 and 4535_AT1 and 4540_AT1 and 4729_AT1) or (4715_AT1 and 4720_AT1 and 4719_AT1 and 55967_AT1 and 4700_AT1 and 4709_AT1 and 4710_AT1 and 4726_AT1 and 4718_AT1 and 4696_AT1 and 374291_AT1 and 4694_AT1 and 4728_AT1 and 7991_AT2 and 4712_AT2 and 4717_AT1 and 4705_AT1 and 4725_AT1 and 4716_AT1 and 4537_AT1 and 4722_AT1 and 4541_AT1 and 4539_AT1 and 4707_AT1 and 4701_AT1 and 4698_AT1 and 4723_AT1 and 4538_AT1 and 4697_AT1 and 51079_AT1 and 4714_AT1 and 4704_AT1 and 4711_AT1 and 126328_AT1 and 4724_AT1 and 4536_AT1 and 4713_AT1 and 4695_AT1 and 4702_AT1 and 4708_AT1 and 4731_AT2 and 4706_AT1 and 4535_AT1 and 4540_AT1 and 4729_AT1) or (4715_AT1 and 4720_AT1 and 4719_AT1 and 4700_AT1 and 55967_AT1 and 4709_AT1 and 4710_AT1 and 4726_AT1 and 4718_AT1 and 4696_AT1 and 374291_AT1 and 4694_AT1 and 4728_AT1 and 4717_AT1 and 4705_AT1 and 4725_AT1 and 4537_AT1 and 4716_AT1 and 4722_AT1 and 7991_AT1 and 4541_AT1 and 4712_AT1 and 4539_AT1 and 4707_AT1 and 4701_AT1 and 4723_AT1 and 4698_AT1 and 4538_AT1 and 4697_AT1 and 51079_AT1 and 4714_AT1 and 4704_AT1 and 4711_AT1 and 126328_AT1 and 4724_AT1 and 4713_AT1 and 4536_AT1 and 4695_AT1 and 4702_AT1 and 4708_AT1 and 4706_AT1 and 4535_AT1 and 4731_AT2 and 4729_AT1 and 4540_AT1) or (4715_AT1 and 4720_AT1 and 4719_AT1 and 55967_AT1 and 4700_AT1 and 4709_AT1 and 4710_AT1 and 4726_AT1 and 4696_AT1 and 4718_AT1 and 4694_AT1 and 374291_AT1 and 4728_AT1 and 4717_AT1 and 4731_AT1 and 4705_AT1 and 4725_AT1 and 4716_AT1 and 4537_AT1 and 4722_AT1 and 7991_AT1 and 4541_AT1 and 4539_AT1 and 4712_AT1 and 4707_AT1 and 4701_AT1 and 4723_AT1 and 4698_AT1 and 4538_AT1 and 4697_AT1 and 51079_AT1 and 4714_AT1 and 4704_AT1 and 126328_AT1 and 4711_AT1 and 4724_AT1 and 4713_AT1 and 4536_AT1 and 4695_AT1 and 4702_AT1 and 4708_AT1 and 4706_AT1 and 4535_AT1 and 4540_AT1 and 4729_AT1) or (4715_AT1 and 4720_AT1 and 4719_AT1 and 55967_AT1 and 4700_AT1 and 4709_AT1 and 4710_AT1 and 4726_AT1 and 4696_AT1 and 4718_AT1 and 374291_AT1 and 4694_AT1 and 4728_AT1 and 4712_AT2 and 4717_AT1 and 4731_AT1 and 4705_AT1 and 4725_AT1 and 4537_AT1 and 4716_AT1 and 4722_AT1 and 7991_AT1 and 4541_AT1 and 4539_AT1 and 4707_AT1 and 4701_AT1 and 4723_AT1 and 4698_AT1 and 4538_AT1 and 4697_AT1 and 51079_AT1 and 4714_AT1 and 4704_AT1 and 126328_AT1 and 4711_AT1 and 4724_AT1 and 4713_AT1 and 4536_AT1 and 4695_AT1 and 4702_AT1 and 4708_AT1 and 4535_AT1 and 4706_AT1 and 4729_AT1 and 4540_AT1) or (4715_AT1 and 4720_AT1 and 4719_AT1 and 4700_AT1 and 55967_AT1 and 4709_AT1 and 4710_AT1 and 4726_AT1 and 4718_AT1 and 4696_AT1 and 4694_AT1 and 374291_AT1 and 4728_AT1 and 7991_AT2 and 4717_AT1 and 4705_AT1 and 4725_AT1 and 4537_AT1 and 4716_AT1 and 4722_AT1 and 4541_AT1 and 4712_AT1 and 4539_AT1 and 4707_AT1 and 4701_AT1 and 4723_AT1 and 4698_AT1 and 4538_AT1 and 4697_AT1 and 51079_AT1 and 4714_AT1 and 4704_AT1 and 4711_AT1 and 126328_AT1 and 4724_AT1 and 4713_AT1 and 4536_AT1 and 4695_AT1 and 4702_AT1 and 4708_AT1 and 4535_AT1 and 4731_AT2 and 4706_AT1 and 4540_AT1 and 4729_AT1) or (4715_AT1 and 4720_AT1 and 4719_AT1 and 4700_AT1 and 55967_AT1 and 4709_AT1 and 4710_AT1 and 4726_AT1 and 4718_AT1 and 4696_AT1 and 374291_AT1 and 4694_AT1 and 4728_AT1 and 7991_AT2 and 4712_AT2 and 4717_AT1 and 4731_AT1 and 4705_AT1 and 4725_AT1 and 4537_AT1 and 4716_AT1 and 4722_AT1 and 4541_AT1 and 4539_AT1 and 4707_AT1 and 4701_AT1 and 4698_AT1 and 4723_AT1 and 4538_AT1 and 4697_AT1 and 51079_AT1 and 4714_AT1 and 4704_AT1 and 4711_AT1 and 126328_AT1 and 4724_AT1 and 4713_AT1 and 4536_AT1 and 4695_AT1 and 4702_AT1 and 4708_AT1 and 4706_AT1 and 4535_AT1 and 4540_AT1 and 4729_AT1)"}, {"subsystem": "Transport, Peroxisomal", "name": "NADHtpu", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADHtpu"]}, "metabolites": {"nadh_x": 1.0, "nadh_c": -1.0}, "id": "NADHtpu", "gene_reaction_rule": ""}, {"subsystem": "Transport, Endoplasmic Reticular", "name": "NADHtru", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADHtru"]}, "metabolites": {"nadh_r": 1.0, "nadh_c": -1.0}, "id": "NADHtru", "gene_reaction_rule": ""}, {"subsystem": "NAD Metabolism", "name": "NAD kinase", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADK"]}, "metabolites": {"h_c": 1.0, "nadp_c": 1.0, "nad_c": -1.0, "atp_c": -1.0, "adp_c": 1.0}, "id": "NADK", "gene_reaction_rule": "65220_AT1"}, {"subsystem": "NAD Metabolism", "name": "NAD nucleosidase", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADN"]}, "metabolites": {"h_c": 1.0, "h2o_c": -1.0, "nad_c": -1.0, "adprib_c": 1.0, "ncam_c": 1.0}, "id": "NADN", "gene_reaction_rule": ""}, {"subsystem": "NAD Metabolism", "name": "NADNe", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADNe"]}, "metabolites": {"adprib_e": 1.0, "ncam_e": 1.0, "h_e": 1.0, "h2o_e": -1.0, "nad_e": -1.0}, "id": "NADNe", "gene_reaction_rule": "952_AT1"}, {"subsystem": "Transport, Endoplasmic Reticular", "name": "NADPHtru", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADPHtru"]}, "metabolites": {"nadph_c": -1.0, "nadph_r": 1.0}, "id": "NADPHtru", "gene_reaction_rule": ""}, {"subsystem": "Transport, Peroxisomal", "name": "NADPHtxu", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADPHtxu"]}, "metabolites": {"nadph_c": -1.0, "nadph_x": 1.0}, "id": "NADPHtxu", "gene_reaction_rule": ""}, {"subsystem": "NAD Metabolism", "name": "NADPN", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADPN"]}, "metabolites": {"adprbp_c": 1.0, "nadp_c": -1.0, "h_c": 1.0, "h2o_c": -1.0, "ncam_c": 1.0}, "id": "NADPN", "gene_reaction_rule": ""}, {"subsystem": "NAD Metabolism", "name": "NADPNe", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADPNe"]}, "metabolites": {"ncam_e": 1.0, "adprbp_e": 1.0, "h2o_e": -1.0, "nadp_e": -1.0, "h_e": 1.0}, "id": "NADPNe", "gene_reaction_rule": "952_AT1"}, {"subsystem": "Transport, Endoplasmic Reticular", "name": "NADPtru", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADPtru"]}, "metabolites": {"nadp_r": -1.0, "nadp_c": 1.0}, "id": "NADPtru", "gene_reaction_rule": ""}, {"subsystem": "Transport, Peroxisomal", "name": "NADPtxu", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADPtxu"]}, "metabolites": {"nadp_x": -1.0, "nadp_c": 1.0}, "id": "NADPtxu", "gene_reaction_rule": ""}, {"subsystem": "NAD Metabolism", "name": "Nicotinate-mononucleotide adenylyltransferase", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADS2"]}, "metabolites": {"dnad_c": -1.0, "h2o_c": -1.0, "atp_c": -1.0, "ppi_c": 1.0, "amp_c": 1.0, "nad_c": 1.0, "gln__L_c": -1.0, "glu__L_c": 1.0, "h_c": 1.0}, "id": "NADS2", "gene_reaction_rule": "55191_AT1"}, {"subsystem": "Transport, Nuclear", "name": "NAD transport nuclear through pores", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["NADtn"]}, "metabolites": {"nad_n": -1.0, "nad_c": 1.0}, "id": "NADtn", "gene_reaction_rule": ""}, {"subsystem": "Transport, Peroxisomal", "name": "NADtpu", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADtpu"]}, "metabolites": {"nadh_x": -1.0, "nadh_c": 1.0}, "id": "NADtpu", "gene_reaction_rule": ""}, {"subsystem": "Transport, Endoplasmic Reticular", "name": "NADtru", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADtru"]}, "metabolites": {"nad_c": 1.0, "nad_r": -1.0}, "id": "NADtru", "gene_reaction_rule": ""}, {"subsystem": "Keratan sulfate degradation", "name": "NAGA2ly", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NAGA2ly"]}, "metabolites": {"udpacgal_l": 1.0, "Ser_Thr_l": 1.0, "h_l": -1.0, "Tn_antigen_l": -1.0, "udp_l": -1.0}, "id": "NAGA2ly", "gene_reaction_rule": "4668_AT1"}, {"subsystem": "Sphingolipid Metabolism", "name": "NAGAlby", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NAGAlby"]}, "metabolites": {"udpacgal_l": 1.0, "acgbgbside_hs_l": -1.0, "h_l": -1.0, "gbside_hs_l": 1.0, "udp_l": -1.0}, "id": "NAGAlby", "gene_reaction_rule": ""}, {"subsystem": "Sphingolipid Metabolism", "name": "NAGAly", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NAGAly"]}, "metabolites": {"udpacgal_l": 1.0, "acgagbside_hs_l": -1.0, "h_l": -1.0, "gbside_hs_l": 1.0, "udp_l": -1.0}, "id": "NAGAly", "gene_reaction_rule": "4668_AT1"}, {"subsystem": "Keratan sulfate degradation", "name": "NAGLCAly", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NAGLCAly"]}, "metabolites": {"acgam_l": 1.0, "Tn_antigen_l": 1.0, "h2o_l": -1.0, "core6_l": -1.0}, "id": "NAGLCAly", "gene_reaction_rule": ""}, {"subsystem": "Transport, Extracellular", "name": "NAHCO3 HCLt", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["NAHCO3_HCLt"]}, "metabolites": {"hco3_c": 1.0, "na1_c": 1.0, "na1_e": -1.0, "hco3_e": -1.0, "cl_e": 1.0, "h_e": 1.0, "h_c": -1.0, "cl_c": -1.0}, "id": "NAHCO3_HCLt", "gene_reaction_rule": "9498_AT1 or 57282_AT1"}, {"subsystem": "Transport, Extracellular", "name": "NAIt", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["NAIt"]}, "metabolites": {"i_e": -1.0, "na1_c": 2.0, "i_c": 1.0, "na1_e": -2.0}, "id": "NAIt", "gene_reaction_rule": "6528_AT1"}, {"subsystem": "Transport, Extracellular", "name": "NAt", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["NAt"]}, "metabolites": {"na1_c": 1.0, "na1_e": -1.0}, "id": "NAt", "gene_reaction_rule": "6526_AT1 or 6523_AT1 or 6528_AT1"}, {"subsystem": "Transport, Extracellular", "name": "Sodium proton antiporter HNA is 11 ", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["NAt3_1"]}, "metabolites": {"na1_c": -1.0, "h_e": -1.0, "na1_e": 1.0, "h_c": 1.0}, "id": "NAt3_1", "gene_reaction_rule": "389015_AT1 or 6549_AT1 or 6548_AT1 or 6550_AT1 or 6553_AT1"}, {"subsystem": "Transport, Golgi Apparatus", "name": "NAt3 1g", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["NAt3_1g"]}, "metabolites": {"h_g": -1.0, "na1_c": -1.0, "h_c": 1.0, "na1_g": 1.0}, "id": "NAt3_1g", "gene_reaction_rule": "84679_AT1 or 23315_AT1"}, {"subsystem": "Transport, Extracellular", "name": "NAt5", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["NAt5"]}, "metabolites": {"na1_c": -1.0, "nh4_e": -1.0, "nh4_c": 1.0, "na1_e": 1.0}, "id": "NAt5", "gene_reaction_rule": "6549_AT1 or 6548_AT1 or 6550_AT1"}, {"subsystem": "Transport, Peroxisomal", "name": "NAtx", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["NAtx"]}, "metabolites": {"na1_x": 1.0, "na1_c": -1.0}, "id": "NAtx", "gene_reaction_rule": ""}, {"subsystem": "beta-Alanine metabolism", "name": "NBAHH ir", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NBAHH_ir"]}, "metabolites": {"carn_c": -1.0, "his__L_c": 1.0, "h2o_c": -1.0, "ala_B_c": 1.0}, "id": "NBAHH_ir", "gene_reaction_rule": "84735_AT1"}, {"subsystem": "Transport, Extracellular", "name": "Nicotinamide acid uptake", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NCAMUP"]}, "metabolites": {"ncam_e": -1.0, "ncam_c": 1.0}, "id": "NCAMUP", "gene_reaction_rule": ""}, {"subsystem": "Transport, Extracellular", "name": "NCCt", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NCCt"]}, "metabolites": {"cl_e": -1.0, "na1_c": 1.0, "na1_e": -1.0, "cl_c": 1.0}, "id": "NCCt", "gene_reaction_rule": "6559_AT1"}, {"subsystem": "Transport, Extracellular", "name": "NCKt", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["NCKt"]}, "metabolites": {"ca2_e": -1.0, "ca2_c": 1.0, "na1_c": -4.0, "na1_e": 4.0, "k_c": 1.0, "k_e": -1.0}, "id": "NCKt", "gene_reaction_rule": "123041_AT2 or 57419_AT1 or 9187_AT1 or 123041_AT3 or 25769_AT1 or 123041_AT1"}, {"subsystem": "Transport, Extracellular", "name": "NCNt", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["NCNt"]}, "metabolites": {"ca2_e": -1.0, "ca2_c": 1.0, "na1_c": -4.0, "na1_e": 4.0, "nh4_e": -1.0, "nh4_c": 1.0}, "id": "NCNt", "gene_reaction_rule": "9187_AT1 or 25769_AT1"}, {"subsystem": "Nucleotides", "name": "NDP10ex", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NDP10ex"]}, "metabolites": {"idp_e": -1.0, "imp_e": 1.0, "h_e": 1.0, "h2o_e": -1.0, "pi_e": 1.0}, "id": "NDP10ex", "gene_reaction_rule": "124583_AT1"}, {"subsystem": "Nucleotides", "name": "NDP3ex", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NDP3ex"]}, "metabolites": {"gdp_e": -1.0, "h_e": 1.0, "h2o_e": -1.0, "gmp_e": 1.0, "pi_e": 1.0}, "id": "NDP3ex", "gene_reaction_rule": "124583_AT1"}, {"subsystem": "Nucleotides", "name": "NDP6", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NDP6"]}, "metabolites": {"dcmp_c": 1.0, "h2o_c": -1.0, "pi_c": 1.0, "h_c": 1.0, "dcdp_c": -1.0}, "id": "NDP6", "gene_reaction_rule": ""}, {"subsystem": "Nucleotides", "name": "NDP7er", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NDP7er"]}, "metabolites": {"ump_r": 1.0, "pi_r": 1.0, "h2o_r": -1.0, "h_r": 1.0, "udp_r": -1.0}, "id": "NDP7er", "gene_reaction_rule": ""}, {"subsystem": "Nucleotides", "name": "NDP7ex", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NDP7ex"]}, "metabolites": {"h2o_e": -1.0, "h_e": 1.0, "udp_e": -1.0, "pi_e": 1.0, "ump_e": 1.0}, "id": "NDP7ex", "gene_reaction_rule": "124583_AT1"}, {"subsystem": "Nucleotides", "name": "NDP7g", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NDP7g"]}, "metabolites": {"udp_g": -1.0, "h_g": 1.0, "ump_g": 1.0, "h2o_g": -1.0, "pi_g": 1.0}, "id": "NDP7g", "gene_reaction_rule": "9583_AT1"}, {"subsystem": "Nucleotides", "name": "NDP8", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NDP8"]}, "metabolites": {"h2o_c": -1.0, "pi_c": 1.0, "dudp_c": -1.0, "dump_c": 1.0, "h_c": 1.0}, "id": "NDP8", "gene_reaction_rule": "1841_AT1"}, {"subsystem": "Nucleotides", "name": "NDP8ex", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NDP8ex"]}, "metabolites": {"h2o_e": -1.0, "h_e": 1.0, "udp_e": 1.0, "pi_e": 1.0, "utp_e": -1.0}, "id": "NDP8ex", "gene_reaction_rule": "124583_AT1"}, {"subsystem": "Nucleotides", "name": "Nucleoside-diphosphate kinase (ATP:GDP)", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["NDPK1"]}, "metabolites": {"gtp_c": 1.0, "gdp_c": -1.0, "atp_c": -1.0, "adp_c": 1.0}, "id": "NDPK1", "gene_reaction_rule": "4832_AT1 or 10201_AT1 or (4831_AT1 and 4830_AT1) or 29922_AT2 or (4830_AT2 and 4831_AT1) or 29922_AT1"}, {"subsystem": "Nucleotides", "name": "Nucleoside-diphosphate kinase (ATP dIDP)", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["NDPK10"]}, "metabolites": {"ditp_c": 1.0, "adp_c": 1.0, "atp_c": -1.0, "didp_c": -1.0}, "id": "NDPK10", "gene_reaction_rule": "(4830_AT2 and 4831_AT1) or 4832_AT1 or 10201_AT1 or 29922_AT2 or 29922_AT1 or (4831_AT1 and 4830_AT1)"}, {"subsystem": "Nucleotides", "name": "NDPK10m", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["NDPK10m"]}, "metabolites": {"adp_m": 1.0, "atp_m": -1.0, "ditp_m": 1.0, "didp_m": -1.0}, "id": "NDPK10m", "gene_reaction_rule": "4833_AT1"}, {"subsystem": "Nucleotides", "name": "NDPK10n", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["NDPK10n"]}, "metabolites": {"didp_n": -1.0, "atp_n": -1.0, "ditp_n": 1.0, "adp_n": 1.0}, "id": "NDPK10n", "gene_reaction_rule": "(4831_AT1 and 4830_AT1) or (4830_AT2 and 4831_AT1)"}, {"subsystem": "Nucleotides", "name": "NDPK1m", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["NDPK1m"]}, "metabolites": {"atp_m": -1.0, "adp_m": 1.0, "gdp_m": -1.0, "gtp_m": 1.0}, "id": "NDPK1m", "gene_reaction_rule": "4833_AT1"}, {"subsystem": "Nucleotides", "name": "NDPK1n", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["NDPK1n"]}, "metabolites": {"gdp_n": -1.0, "adp_n": 1.0, "atp_n": -1.0, "gtp_n": 1.0}, "id": "NDPK1n", "gene_reaction_rule": "(4831_AT1 and 4830_AT1) or (4830_AT2 and 4831_AT1)"}, {"subsystem": "Nucleotides", "name": "Nucleoside-diphosphate kinase (ATP:UDP)", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["NDPK2"]}, "metabolites": {"udp_c": -1.0, "utp_c": 1.0, "atp_c": -1.0, "adp_c": 1.0}, "id": "NDPK2", "gene_reaction_rule": "4832_AT1 or 29922_AT1 or (4831_AT1 and 4830_AT1) or 10201_AT1 or (4830_AT2 and 4831_AT1) or 29922_AT2"}, {"subsystem": "Nucleotides", "name": "NDPK2m", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["NDPK2m"]}, "metabolites": {"atp_m": -1.0, "adp_m": 1.0, "utp_m": 1.0, "udp_m": -1.0}, "id": "NDPK2m", "gene_reaction_rule": "4833_AT1"}, {"subsystem": "Nucleotides", "name": "NDPK2n", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": 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"PGDI", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["PGDI"]}, "metabolites": {"prostgd2_c": 1.0, "prostgh2_c": -1.0}, "id": "PGDI", "gene_reaction_rule": "5730_AT1 or 27306_AT1"}, {"subsystem": "Eicosanoid Metabolism", "name": "PGDIr", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["PGDIr"]}, "metabolites": {"prostgd2_r": 1.0, "prostgh2_r": -1.0}, "id": "PGDIr", "gene_reaction_rule": "5730_AT1 or 27306_AT1"}, {"subsystem": "Eicosanoid Metabolism", "name": "PGESr", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["PGESr"]}, "metabolites": {"prostgh2_r": -1.0, "prostge2_r": 1.0}, "id": "PGESr", "gene_reaction_rule": "80142_AT4 or 80142_AT2 or 9536_AT1 or 80142_AT1 or 9536_AT2 or 80142_AT3"}, {"subsystem": "Glycolysis/Gluconeogenesis", "name": "Glucose-6-phosphate isomerase", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["PGI"]}, "metabolites": 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"atp_c": -1.0}, "id": "PI3P5K", "gene_reaction_rule": "8394_AT1 or 23396_AT1 or 8395_AT1"}, {"subsystem": "Inositol Phosphate Metabolism", "name": "PI3PP", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PI3PP"]}, "metabolites": {"pail_hs_c": 1.0, "h2o_c": -1.0, "pi_c": 1.0, "pail3p_hs_c": -1.0}, "id": "PI3PP", "gene_reaction_rule": "8897_AT2 or 8897_AT3 or 8897_AT1"}, {"subsystem": "Inositol Phosphate Metabolism", "name": "PI45P3K", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PI45P3K"]}, "metabolites": {"pail45p_hs_c": -1.0, "pail345p_hs_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "atp_c": -1.0}, "id": "PI45P3K", "gene_reaction_rule": "(5293_AT1 and 8503_AT1) or (5293_AT1 and 5295_AT1) or (5291_AT1 and 5295_AT1) or (5295_AT2 and 5290_AT1) or (5290_AT1 and 5295_AT1) or (5290_AT1 and 5295_AT3) or (5291_AT1 and 8503_AT1) or (5291_AT1 and 5295_AT3) or (5296_AT1 and 5290_AT1) or (5293_AT1 and 5295_AT3) or (5296_AT1 and 5291_AT1) or (23533_AT1 and 5294_AT1) or (10870_AT1 and 5294_AT1) or (5295_AT2 and 5293_AT1) or (5290_AT1 and 8503_AT1) or (5293_AT1 and 5296_AT1) or (5295_AT2 and 5291_AT1)"}, {"subsystem": "Inositol Phosphate Metabolism", "name": "PI45P3Kn", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PI45P3Kn"]}, "metabolites": {"h_n": 1.0, "adp_n": 1.0, "pail45p_hs_n": -1.0, "atp_n": -1.0, "pail345p_hs_n": 1.0}, "id": "PI45P3Kn", "gene_reaction_rule": ""}, {"subsystem": "Inositol Phosphate Metabolism", "name": "PI45P4P", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PI45P4P"]}, "metabolites": {"pail45p_hs_c": -1.0, "h2o_c": -1.0, "pi_c": 1.0, "pail5p_hs_c": 1.0}, "id": "PI45P4P", "gene_reaction_rule": ""}, {"subsystem": "Inositol Phosphate Metabolism", "name": "PI45P5P", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PI45P5P"]}, "metabolites": {"pail45p_hs_c": -1.0, "h2o_c": -1.0, "pi_c": 1.0, "pail4p_hs_c": 1.0}, "id": "PI45P5P", "gene_reaction_rule": "8867_AT1 or 56623_AT1 or 4952_AT1 or 8871_AT1 or 8867_AT2 or 4952_AT2 or 3633_AT1"}, {"subsystem": "Inositol Phosphate Metabolism", "name": "PI45P5Pn", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PI45P5Pn"]}, "metabolites": {"pail4p_hs_n": 1.0, "pail45p_hs_n": -1.0, "pi_n": 1.0, "h2o_n": -1.0}, "id": "PI45P5Pn", "gene_reaction_rule": ""}, {"subsystem": "Inositol Phosphate Metabolism", "name": "PI45PLC", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PI45PLC"]}, "metabolites": {"pail45p_hs_c": -1.0, "dag_hs_c": 1.0, "mi145p_c": 1.0, "h_c": 1.0, "h2o_c": -1.0}, "id": "PI45PLC", "gene_reaction_rule": "23236_AT2 or 5336_AT1 or 9651_AT1 or 113026_AT1 or 89869_AT1 or 84812_AT1 or 5330_AT1 or 5335_AT1 or 51196_AT1 or 5333_AT1 or 5332_AT2 or 5331_AT1 or 5335_AT2 or 5334_AT1 or 5332_AT1 or 257068_AT1 or 23236_AT1 or 23007_AT1"}, {"subsystem": "Inositol Phosphate Metabolism", "name": "PI45PLCn", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PI45PLCn"]}, "metabolites": {"h_n": 1.0, "mi145p_n": 1.0, "dag_hs_n": 1.0, "pail45p_hs_n": -1.0, "h2o_n": -1.0}, "id": "PI45PLCn", "gene_reaction_rule": "23236_AT1 or 23236_AT2"}, {"subsystem": "Inositol Phosphate Metabolism", "name": "PI4P3K", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PI4P3K"]}, "metabolites": {"h_c": 1.0, "pail34p_hs_c": 1.0, "adp_c": 1.0, "atp_c": -1.0, "pail4p_hs_c": -1.0}, "id": "PI4P3K", "gene_reaction_rule": "(5291_AT1 and 5295_AT3) or (5296_AT1 and 5290_AT1) or (5293_AT1 and 5296_AT1) or 5287_AT1 or 5286_AT1 or (5293_AT1 and 8503_AT1) or (5293_AT1 and 5295_AT3) or (5291_AT1 and 8503_AT1) or (5295_AT2 and 5290_AT1) or 5288_AT1 or (5291_AT1 and 5295_AT1) or (5296_AT1 and 5291_AT1) or (23533_AT1 and 5294_AT1) or (5293_AT1 and 5295_AT1) or (5295_AT2 and 5293_AT1) or (5290_AT1 and 8503_AT1) or (5290_AT1 and 5295_AT3) or (10870_AT1 and 5294_AT1) or (5295_AT2 and 5291_AT1) or (5290_AT1 and 5295_AT1)"}, {"subsystem": "Inositol Phosphate Metabolism", "name": "PI4P3Ker", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PI4P3Ker"]}, "metabolites": {"pail34p_hs_r": 1.0, "atp_r": -1.0, "h_r": 1.0, "pail4p_hs_r": -1.0, "adp_r": 1.0}, "id": "PI4P3Ker", "gene_reaction_rule": "5287_AT1"}, {"subsystem": "Inositol Phosphate Metabolism", "name": "PI4P3Kn", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PI4P3Kn"]}, "metabolites": {"h_n": 1.0, "pail4p_hs_n": -1.0, "adp_n": 1.0, "pail34p_hs_n": 1.0, "atp_n": -1.0}, "id": "PI4P3Kn", "gene_reaction_rule": ""}, {"subsystem": "Inositol Phosphate Metabolism", "name": "PI4P4Pn", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PI4P4Pn"]}, "metabolites": {"pail4p_hs_n": -1.0, "pail_hs_n": 1.0, "pi_n": 1.0, "h2o_n": -1.0}, "id": "PI4P4Pn", "gene_reaction_rule": ""}, {"subsystem": "Glycerophospholipid Metabolism", "name": "PI4P5K", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PI4P5K"]}, "metabolites": {"pail45p_hs_c": 1.0, "pail4p_hs_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "atp_c": -1.0}, "id": "PI4P5K", "gene_reaction_rule": "200576_AT2 or 8396_AT1 or 200576_AT3 or 79837_AT1 or 8394_AT1 or 23396_AT1 or 8395_AT1 or 8396_AT2 or 5305_AT1 or 200576_AT1"}, {"subsystem": "Inositol Phosphate Metabolism", "name": "PI4P5Kn", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PI4P5Kn"]}, "metabolites": {"h_n": 1.0, "pail4p_hs_n": -1.0, "adp_n": 1.0, "pail45p_hs_n": 1.0, "atp_n": -1.0}, "id": "PI4P5Kn", "gene_reaction_rule": ""}, {"subsystem": "Inositol Phosphate Metabolism", "name": "PI4PLC", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PI4PLC"]}, "metabolites": {"h_c": 1.0, "dag_hs_c": 1.0, "mi14p_c": 1.0, "h2o_c": -1.0, "pail4p_hs_c": -1.0}, "id": "PI4PLC", "gene_reaction_rule": "23236_AT1 or 51196_AT1 or 9651_AT1 or 113026_AT1 or 89869_AT1 or 23007_AT1 or 5334_AT1 or 5331_AT1 or 5333_AT1 or 257068_AT1 or 5332_AT1 or 23236_AT2 or 5335_AT1 or 5335_AT2 or 5336_AT1 or 5330_AT1 or 5332_AT2 or 84812_AT1"}, {"subsystem": "Inositol Phosphate Metabolism", "name": "PI4PLCn", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PI4PLCn"]}, "metabolites": {"h_n": 1.0, "pail4p_hs_n": -1.0, "mi14p_n": 1.0, "dag_hs_n": 1.0, "h2o_n": -1.0}, "id": "PI4PLCn", "gene_reaction_rule": "23236_AT2 or 23236_AT1"}, {"subsystem": "Inositol Phosphate Metabolism", "name": "PI4PP", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PI4PP"]}, "metabolites": {"pail_hs_c": 1.0, "h2o_c": -1.0, "pi_c": 1.0, "pail4p_hs_c": -1.0}, "id": "PI4PP", "gene_reaction_rule": ""}, {"subsystem": "Inositol Phosphate Metabolism", "name": "PI5P3K", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PI5P3K"]}, "metabolites": {"pail35p_hs_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "pail5p_hs_c": -1.0, "atp_c": -1.0}, "id": "PI5P3K", "gene_reaction_rule": "(5295_AT2 and 5291_AT1) or (23533_AT1 and 5294_AT1) or (5295_AT2 and 5290_AT1) or (5293_AT1 and 5295_AT3) or 5287_AT1 or 5286_AT1 or (5293_AT1 and 5296_AT1) or (5295_AT2 and 5293_AT1) or (5296_AT1 and 5291_AT1) or (5290_AT1 and 5295_AT1) or 5288_AT1 or (5290_AT1 and 8503_AT1) or (5291_AT1 and 5295_AT3) or (10870_AT1 and 5294_AT1) or (5291_AT1 and 8503_AT1) or (5293_AT1 and 5295_AT1) or (5296_AT1 and 5290_AT1) or 5289_AT1 or (5293_AT1 and 8503_AT1) or (5291_AT1 and 5295_AT1) or (5290_AT1 and 5295_AT3)"}, {"subsystem": "Inositol Phosphate Metabolism", "name": "PI5P3Ker", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PI5P3Ker"]}, "metabolites": {"pail35p_hs_r": 1.0, "pail5p_hs_r": -1.0, "atp_r": -1.0, "h_r": 1.0, "adp_r": 1.0}, "id": "PI5P3Ker", "gene_reaction_rule": "5287_AT1"}, {"subsystem": "Inositol Phosphate Metabolism", "name": "PI5P4K", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PI5P4K"]}, "metabolites": {"pail45p_hs_c": 1.0, "pail5p_hs_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "atp_c": -1.0}, "id": "PI5P4K", "gene_reaction_rule": "5297_AT1 or 55361_AT1 or 5298_AT1"}, {"subsystem": "Inositol Phosphate Metabolism", "name": "PI5P4Kn", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PI5P4Kn"]}, "metabolites": {"h_n": 1.0, "atp_n": -1.0, "pail5p_hs_n": -1.0, "pail45p_hs_n": 1.0, "adp_n": 1.0}, "id": "PI5P4Kn", "gene_reaction_rule": ""}, {"subsystem": "Glycosylphosphatidylinositol (GPI)-anchor biosynthesis", "name": "PIACGT", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PIACGT"]}, "metabolites": {"uacgam_c": -1.0, "pail_hs_c": -1.0, "udp_c": 1.0, "h_c": 1.0, "acgpail_hs_c": 1.0}, "id": "PIACGT", "gene_reaction_rule": "(5279_AT1 and 51227_AT2 and 5283_AT1 and 5277_AT2 and 9091_AT1 and 8818_AT1) or (5279_AT1 and 51227_AT2 and 5283_AT1 and 9091_AT1 and 5277_AT2 and 8818_AT1) or (51227_AT1 and 9091_AT2 and 5277_AT3 and 5283_AT1 and 5279_AT2 and 8818_AT1) or (51227_AT2 and 5277_AT1 and 5283_AT1 and 9091_AT1 and 8818_AT2 and 5279_AT2) or (51227_AT3 and 9091_AT2 and 5277_AT3 and 5283_AT1 and 5279_AT2 and 8818_AT1) or (5279_AT1 and 51227_AT1 and 9091_AT2 and 5277_AT1 and 5283_AT1 and 8818_AT2) or (51227_AT3 and 9091_AT2 and 5277_AT1 and 5283_AT1 and 5279_AT2 and 8818_AT1) or (51227_AT1 and 9091_AT2 and 5277_AT1 and 5283_AT1 and 8818_AT1 and 5279_AT2) or (51227_AT3 and 9091_AT2 and 5277_AT3 and 5283_AT1 and 5279_AT2 and 8818_AT2) or (51227_AT1 and 5277_AT1 and 5283_AT1 and 9091_AT1 and 5279_AT2 and 8818_AT1) or (51227_AT2 and 5283_AT1 and 9091_AT1 and 5277_AT2 and 8818_AT1 and 5279_AT2) or (5279_AT1 and 51227_AT1 and 9091_AT2 and 5277_AT3 and 5283_AT1 and 8818_AT2) or (51227_AT3 and 9091_AT2 and 5277_AT1 and 5283_AT1 and 8818_AT2 and 5279_AT2) or (5279_AT1 and 51227_AT2 and 5277_AT3 and 5283_AT1 and 9091_AT1 and 8818_AT2) or (51227_AT1 and 5277_AT3 and 5283_AT1 and 9091_AT1 and 8818_AT1 and 5279_AT2) or (51227_AT2 and 5277_AT1 and 5283_AT1 and 9091_AT1 and 8818_AT1 and 5279_AT2) or (5279_AT1 and 51227_AT2 and 9091_AT2 and 5277_AT1 and 5283_AT1 and 8818_AT1) or (5279_AT1 and 51227_AT1 and 9091_AT2 and 5283_AT1 and 5277_AT2 and 8818_AT2) or (5279_AT1 and 9091_AT2 and 51227_AT2 and 5277_AT2 and 5283_AT1 and 8818_AT2) or (5279_AT1 and 9091_AT2 and 51227_AT2 and 5277_AT1 and 5283_AT1 and 8818_AT2) or (51227_AT3 and 5283_AT1 and 5277_AT2 and 9091_AT1 and 8818_AT1 and 5279_AT2) or (51227_AT2 and 5277_AT3 and 5283_AT1 and 9091_AT1 and 8818_AT1 and 5279_AT2) or (5279_AT1 and 51227_AT1 and 5283_AT1 and 5277_AT2 and 9091_AT1 and 8818_AT2) or (51227_AT3 and 9091_AT2 and 5283_AT1 and 5277_AT2 and 5279_AT2 and 8818_AT1) or (5279_AT1 and 51227_AT3 and 9091_AT2 and 5283_AT1 and 5277_AT2 and 8818_AT2) or (51227_AT1 and 9091_AT2 and 5277_AT3 and 5283_AT1 and 8818_AT2 and 5279_AT2) or (5279_AT1 and 51227_AT3 and 5277_AT3 and 5283_AT1 and 9091_AT1 and 8818_AT2) or (51227_AT1 and 5283_AT1 and 5277_AT2 and 9091_AT1 and 5279_AT2 and 8818_AT2) or (5279_AT1 and 51227_AT3 and 5277_AT1 and 5283_AT1 and 9091_AT1 and 8818_AT1) or (5279_AT1 and 51227_AT3 and 9091_AT2 and 5277_AT1 and 5283_AT1 and 8818_AT2) or (5279_AT1 and 51227_AT1 and 5277_AT3 and 5283_AT1 and 9091_AT1 and 8818_AT1) or (5279_AT1 and 51227_AT3 and 9091_AT2 and 5277_AT3 and 5283_AT1 and 8818_AT2) or (5279_AT1 and 51227_AT2 and 5277_AT3 and 9091_AT1 and 5283_AT1 and 8818_AT1) or (51227_AT2 and 5277_AT3 and 9091_AT1 and 5283_AT1 and 8818_AT2 and 5279_AT2) or (51227_AT2 and 9091_AT2 and 5277_AT2 and 5283_AT1 and 8818_AT1 and 5279_AT2) or (51227_AT1 and 9091_AT2 and 5277_AT1 and 5283_AT1 and 8818_AT2 and 5279_AT2) or (51227_AT1 and 5277_AT3 and 5283_AT1 and 9091_AT1 and 5279_AT2 and 8818_AT2) or (5279_AT1 and 51227_AT1 and 9091_AT2 and 5277_AT3 and 5283_AT1 and 8818_AT1) or (51227_AT2 and 9091_AT2 and 5277_AT3 and 5283_AT1 and 8818_AT1 and 5279_AT2) or (51227_AT3 and 5277_AT3 and 9091_AT1 and 5283_AT1 and 5279_AT2 and 8818_AT2) or (9091_AT2 and 51227_AT2 and 5277_AT3 and 5283_AT1 and 5279_AT2 and 8818_AT2) or (5279_AT1 and 9091_AT2 and 51227_AT2 and 5277_AT3 and 5283_AT1 and 8818_AT2) or (51227_AT1 and 5277_AT1 and 5283_AT1 and 9091_AT1 and 8818_AT2 and 5279_AT2) or (5279_AT1 and 9091_AT2 and 51227_AT2 and 5277_AT3 and 5283_AT1 and 8818_AT1) or (5279_AT1 and 51227_AT1 and 9091_AT2 and 5277_AT2 and 5283_AT1 and 8818_AT1) or (51227_AT3 and 5277_AT1 and 9091_AT1 and 5283_AT1 and 5279_AT2 and 8818_AT2) or (5279_AT1 and 51227_AT1 and 9091_AT1 and 5277_AT2 and 5283_AT1 and 8818_AT1) or (51227_AT1 and 5283_AT1 and 9091_AT1 and 5277_AT2 and 5279_AT2 and 8818_AT1) or (5279_AT1 and 51227_AT3 and 9091_AT2 and 5277_AT1 and 5283_AT1 and 8818_AT1) or (51227_AT3 and 5277_AT3 and 5283_AT1 and 9091_AT1 and 8818_AT1 and 5279_AT2) or (51227_AT3 and 5279_AT1 and 9091_AT2 and 5277_AT3 and 5283_AT1 and 8818_AT1) or (51227_AT3 and 9091_AT1 and 5283_AT1 and 5277_AT2 and 5279_AT2 and 8818_AT2) or (51227_AT3 and 5277_AT1 and 5283_AT1 and 9091_AT1 and 8818_AT1 and 5279_AT2) or (5279_AT1 and 51227_AT1 and 5277_AT3 and 5283_AT1 and 9091_AT1 and 8818_AT2) or (9091_AT2 and 51227_AT2 and 5277_AT1 and 5283_AT1 and 5279_AT2 and 8818_AT1) or (51227_AT1 and 9091_AT2 and 5277_AT2 and 5283_AT1 and 8818_AT1 and 5279_AT2) or (51227_AT2 and 5283_AT1 and 5277_AT2 and 9091_AT1 and 8818_AT2 and 5279_AT2) or (9091_AT2 and 51227_AT2 and 5277_AT1 and 5283_AT1 and 8818_AT2 and 5279_AT2) or (5279_AT1 and 51227_AT3 and 5277_AT1 and 5283_AT1 and 9091_AT1 and 8818_AT2) or (5279_AT1 and 51227_AT1 and 9091_AT2 and 5277_AT1 and 5283_AT1 and 8818_AT1) or (5279_AT1 and 51227_AT3 and 5277_AT3 and 5283_AT1 and 9091_AT1 and 8818_AT1) or (5279_AT1 and 51227_AT3 and 5283_AT1 and 5277_AT2 and 9091_AT1 and 8818_AT1) or (5279_AT1 and 51227_AT2 and 5277_AT1 and 9091_AT1 and 5283_AT1 and 8818_AT2) or (51227_AT3 and 9091_AT2 and 5283_AT1 and 5277_AT2 and 8818_AT2 and 5279_AT2) or (9091_AT2 and 51227_AT2 and 5283_AT1 and 5277_AT2 and 5279_AT2 and 8818_AT2) or (5279_AT1 and 51227_AT2 and 5277_AT1 and 9091_AT1 and 5283_AT1 and 8818_AT1) or (5279_AT1 and 51227_AT3 and 9091_AT2 and 5283_AT1 and 5277_AT2 and 8818_AT1) or (5279_AT1 and 51227_AT1 and 5277_AT1 and 5283_AT1 and 9091_AT1 and 8818_AT1) or (5279_AT1 and 9091_AT2 and 51227_AT2 and 5277_AT2 and 5283_AT1 and 8818_AT1) or (5279_AT1 and 51227_AT3 and 9091_AT1 and 5277_AT2 and 5283_AT1 and 8818_AT2) or (51227_AT1 and 9091_AT2 and 5283_AT1 and 5277_AT2 and 8818_AT2 and 5279_AT2) or (5279_AT1 and 51227_AT1 and 5277_AT1 and 9091_AT1 and 5283_AT1 and 8818_AT2)"}, {"subsystem": "Inositol Phosphate Metabolism", "name": "PIK3", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PIK3"]}, "metabolites": {"pail_hs_c": -1.0, "pail3p_hs_c": 1.0, "h_c": 1.0, "atp_c": -1.0, "adp_c": 1.0}, "id": "PIK3", "gene_reaction_rule": "(5295_AT2 and 5291_AT1) or (23533_AT1 and 5294_AT1) or (5290_AT1 and 5295_AT1) or (5293_AT1 and 5295_AT3) or 5287_AT1 or 5286_AT1 or (5293_AT1 and 5296_AT1) or (5295_AT2 and 5293_AT1) or (5296_AT1 and 5291_AT1) or (5290_AT1 and 5295_AT3) or 5288_AT1 or (5290_AT1 and 8503_AT1) or (5291_AT1 and 5295_AT3) or (10870_AT1 and 5294_AT1) or (5291_AT1 and 8503_AT1) or (5293_AT1 and 5295_AT1) or (5296_AT1 and 5290_AT1) or 5289_AT1 or (5293_AT1 and 8503_AT1) or (5291_AT1 and 5295_AT1) or (5295_AT2 and 5290_AT1)"}, {"subsystem": "Inositol Phosphate Metabolism", "name": "PIK3er", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PIK3er"]}, "metabolites": {"pail_hs_r": -1.0, "atp_r": -1.0, "h_r": 1.0, "pail3p_hs_r": 1.0, "adp_r": 1.0}, "id": "PIK3er", "gene_reaction_rule": "5287_AT1"}, {"subsystem": "Inositol Phosphate Metabolism", "name": "PIK3n", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PIK3n"]}, "metabolites": {"h_n": 1.0, "pail3p_hs_n": 1.0, "atp_n": -1.0, "pail_hs_n": -1.0, "adp_n": 1.0}, "id": "PIK3n", "gene_reaction_rule": ""}, {"subsystem": "Glycerophospholipid Metabolism", "name": "PIK4", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PIK4"]}, "metabolites": {"h_c": 1.0, "pail_hs_c": -1.0, "adp_c": 1.0, "atp_c": -1.0, "pail4p_hs_c": 1.0}, "id": "PIK4", "gene_reaction_rule": "5298_AT1 or 55361_AT1 or 5297_AT1"}, {"subsystem": "Inositol Phosphate Metabolism", "name": "PIK4n", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PIK4n"]}, "metabolites": {"h_n": 1.0, "pail4p_hs_n": 1.0, "atp_n": -1.0, "pail_hs_n": -1.0, "adp_n": 1.0}, "id": "PIK4n", "gene_reaction_rule": ""}, {"subsystem": "Inositol Phosphate Metabolism", "name": "PIK5", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PIK5"]}, "metabolites": {"pail_hs_c": -1.0, "atp_c": -1.0, "h_c": 1.0, "pail5p_hs_c": 1.0, "adp_c": 1.0}, "id": "PIK5", "gene_reaction_rule": "8394_AT1 or 23396_AT1 or 8395_AT1"}, {"subsystem": "Inositol Phosphate Metabolism", "name": "PIK5n", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PIK5n"]}, "metabolites": {"h_n": 1.0, "pail5p_hs_n": 1.0, "atp_n": -1.0, "pail_hs_n": -1.0, "adp_n": 1.0}, "id": "PIK5n", "gene_reaction_rule": ""}, {"subsystem": "Inositol Phosphate Metabolism", "name": "PIPLC", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PIPLC"]}, "metabolites": {"mi1p__D_c": 1.0, "h2o_c": -1.0, "pail_hs_c": -1.0, "dag_hs_c": 1.0, "h_c": 1.0}, "id": "PIPLC", "gene_reaction_rule": "23236_AT2 or 5336_AT1 or 23007_AT1 or 113026_AT1 or 89869_AT1 or 84812_AT1 or 9651_AT1 or 5335_AT1 or 51196_AT1 or 257068_AT1 or 5332_AT2 or 5331_AT1 or 5335_AT2 or 5334_AT1 or 5332_AT1 or 5330_AT1 or 23236_AT1 or 5333_AT1"}, {"subsystem": "Inositol Phosphate Metabolism", "name": "PIPLCn", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PIPLCn"]}, "metabolites": {"h_n": 1.0, "mi1p__D_n": 1.0, "pail_hs_n": -1.0, "dag_hs_n": 1.0, "h2o_n": -1.0}, "id": "PIPLCn", "gene_reaction_rule": "23236_AT2 or 23236_AT1"}, {"subsystem": "Transport, Mitochondrial", "name": "Phosphate transporter mitochondrial", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["PIt2m"]}, "metabolites": {"pi_c": -1.0, "h_m": 1.0, "h_c": -1.0, "pi_m": 1.0}, "id": "PIt2m", "gene_reaction_rule": "5250_AT4 or 5250_AT1 or 5250_AT3 or 5250_AT2"}, {"subsystem": "Transport, Extracellular", "name": "Phosphate transport in/out via three Na+ symporter", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["PIt7", "PIt7ir"]}, "metabolites": {"na1_c": 3.0, "pi_c": 1.0, "pi_e": -1.0, "na1_e": -3.0}, "id": "PIt7_copy1", "gene_reaction_rule": "6569_AT1 or 10568_AT1"}, {"subsystem": "Transport, Extracellular", "name": "Phosphate transport in/out via three Na+ symporter", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PIt7", "PIt7ir"]}, "metabolites": {"na1_c": 3.0, "pi_c": 1.0, "pi_e": -1.0, "na1_e": -3.0}, "id": "PIt7_copy2", "gene_reaction_rule": "10050_AT1 or 10786_AT1 or 10246_AT1 or 6568_AT1"}, {"subsystem": "Transport, Extracellular", "name": "PIt8", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["PIt8"]}, "metabolites": {"na1_c": 1.5, "pi_c": 1.0, "na1_e": -1.5, "pi_e": -1.0}, "id": "PIt8", "gene_reaction_rule": "6574_AT1 or 6575_AT1"}, {"subsystem": "Transport, Extracellular", "name": "PIt9", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["PIt9"]}, "metabolites": {"na1_c": 2.0, "pi_c": 1.0, "na1_e": -2.0, "pi_e": -1.0}, "id": "PIt9", "gene_reaction_rule": "142680_AT1"}, {"subsystem": "Transport, Endoplasmic Reticular", "name": "PIter", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["PIter"]}, "metabolites": {"pi_r": -1.0, "pi_c": 1.0}, "id": "PIter", "gene_reaction_rule": "2544_AT1"}, {"subsystem": "Transport, Golgi Apparatus", "name": "PItg", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PItg"]}, "metabolites": {"pi_c": 1.0, "pi_g": -1.0}, "id": "PItg", "gene_reaction_rule": ""}, {"subsystem": "Transport, Nuclear", "name": "PItn", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["PItn"]}, "metabolites": {"pi_c": 1.0, "pi_n": -1.0}, "id": "PItn", "gene_reaction_rule": ""}, {"subsystem": "Transport, Peroxisomal", "name": "PItx", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["PItx"]}, "metabolites": {"pi_x": 1.0, "pi_c": -1.0}, "id": "PItx", "gene_reaction_rule": ""}, {"subsystem": "Glycerophospholipid Metabolism", "name": "PLA2", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PLA2"]}, "metabolites": {"ak2gchol_hs_c": -1.0, "Rtotal2_c": 1.0, "h2o_c": -1.0, "ak2lgchol_hs_c": 1.0, "h_c": 1.0}, "id": "PLA2", "gene_reaction_rule": ""}, {"subsystem": "Glycerophospholipid Metabolism", "name": "PLA2 2", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PLA2_2"]}, "metabolites": {"pchol_hs_c": -1.0, "Rtotal2_c": 1.0, "h2o_c": -1.0, "lpchol_hs_c": 1.0, "h_c": 1.0}, "id": "PLA2_2", "gene_reaction_rule": "8398_AT1 or 5320_AT1 or 8398_AT2"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "PLA2 2e", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PLA2_2e"]}, "metabolites": {"h2o_e": -1.0, "lpchol_hs_e": 1.0, "h_e": 1.0, "pchol_hs_e": -1.0, "Rtotal2_e": 1.0}, "id": "PLA2_2e", "gene_reaction_rule": "30814_AT1 or 26279_AT1 or 5320_AT1 or 8399_AT1 or 5322_AT1 or 64600_AT1 or 5319_AT1 or 81579_AT1"}, {"subsystem": "Lysine Metabolism", "name": "PLYSPSer", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PLYSPSer"]}, "metabolites": {"pepslys_r": 1.0, "Ntmelys_r": -1.0, "tmlys_r": 1.0, "h2o_r": -1.0}, "id": "PLYSPSer", "gene_reaction_rule": "60559_AT1 and 28972_AT1 and 90701_AT1 and 9789_AT1 and 23478_AT1"}, {"subsystem": "Fructose and Mannose Metabolism", "name": "Phosphomannomutase", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["PMANM"]}, "metabolites": {"man1p_c": -1.0, "man6p_c": 1.0}, "id": "PMANM", "gene_reaction_rule": "5372_AT1 or 55276_AT1 or 5373_AT1"}, {"subsystem": "Cholesterol Metabolism", "name": "PMEVKx", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PMEVKx"]}, "metabolites": {"5dpmev_x": 1.0, "5pmev_x": -1.0, "atp_x": -1.0, "adp_x": 1.0}, "id": "PMEVKx", "gene_reaction_rule": "10654_AT1"}, {"subsystem": "Inositol Phosphate Metabolism", "name": "5 diphosphoinositol 1 2 3 4 6 pentakisphosphate diphosphohydrolase", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PMI12346PH"]}, "metabolites": {"minohp_c": 1.0, "h2o_c": -1.0, "pi_c": 1.0, "h_c": 1.0, "ppmi12346p_c": -1.0}, "id": "PMI12346PH", "gene_reaction_rule": "117283_AT1 or 9807_AT2 or 9807_AT1"}, {"subsystem": "Inositol Phosphate Metabolism", "name": "PMI12346PHn", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PMI12346PHn"]}, "metabolites": {"h_n": 1.0, "ppmi12346p_n": -1.0, "minohp_n": 1.0, "pi_n": 1.0, "h2o_n": -1.0}, "id": "PMI12346PHn", "gene_reaction_rule": "51447_AT3 or 9807_AT2 or 51447_AT4 or 51447_AT6 or 9807_AT1 or 51447_AT5 or 117283_AT1 or 51447_AT1 or 51447_AT2"}, {"subsystem": "Inositol Phosphate Metabolism", "name": "Diphosphoinositol 1 3 4 6 tetrakisphosphate diphosphohydrolase", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PMI1346PH"]}, "metabolites": {"mi13456p_c": 1.0, "h2o_c": -1.0, "pi_c": 1.0, "ppmi1346p_c": -1.0, "h_c": 1.0}, "id": "PMI1346PH", "gene_reaction_rule": "117283_AT1 or 9807_AT2 or 9807_AT1"}, {"subsystem": "Inositol Phosphate Metabolism", "name": "PMI1346PHn", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PMI1346PHn"]}, "metabolites": {"h_n": 1.0, "ppmi1346p_n": -1.0, "mi13456p_n": 1.0, "pi_n": 1.0, "h2o_n": -1.0}, "id": "PMI1346PHn", "gene_reaction_rule": "117283_AT1 or 51447_AT4 or 9807_AT1 or 51447_AT1 or 51447_AT3 or 9807_AT2 or 51447_AT2 or 51447_AT5 or 51447_AT6"}, {"subsystem": "Transport, Peroxisomal", "name": "PMTCOAtx", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["PMTCOAtx"]}, "metabolites": {"pmtcoa_c": -1.0, "pmtcoa_x": 1.0}, "id": "PMTCOAtx", "gene_reaction_rule": ""}, {"subsystem": "NAD Metabolism", "name": "Purine nucleoside phosphorylase", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["PNP"]}, "metabolites": {"rnam_c": -1.0, "pi_c": -1.0, "h_c": 1.0, "r1p_c": 1.0, "ncam_c": 1.0}, "id": "PNP", "gene_reaction_rule": "4860_AT1"}, {"subsystem": "CoA Catabolism", "name": "PNTEH", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PNTEH"]}, "metabolites": {"ptth_c": -1.0, "cysam_c": 1.0, "h2o_c": -1.0, "pnto__R_c": 1.0}, "id": "PNTEH", "gene_reaction_rule": "(8876_AT1 and 8875_AT2 and 55350_AT3) or (8876_AT1 and 8875_AT2 and 55350_AT2) or (8876_AT1 and 8875_AT1 and 55350_AT1) or (8876_AT1 and 55350_AT2 and 8875_AT1) or (8875_AT2 and 8876_AT1 and 55350_AT1) or (8876_AT1 and 55350_AT3 and 8875_AT1)"}, {"subsystem": "CoA Biosynthesis", "name": "Pantothenate kinase", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PNTK"]}, "metabolites": {"4ppan_c": 1.0, "pnto__R_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "atp_c": -1.0}, "id": "PNTK", "gene_reaction_rule": "79646_AT1 or 80025_AT2 or 53354_AT1 or 53354_AT3 or 80025_AT1 or 53354_AT2 or 80025_AT3 or 80025_AT4 or 55229_AT1"}, {"subsystem": "CoA Biosynthesis", "name": "PNTKm", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PNTKm"]}, "metabolites": {"atp_m": -1.0, "adp_m": 1.0, "pnto__R_m": -1.0, "h_m": 1.0, "4ppan_m": 1.0}, "id": "PNTKm", "gene_reaction_rule": "80025_AT5"}, {"subsystem": "Transport, Extracellular", "name": "PNTOt5", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PNTOt5"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "pnto__R_e": -1.0, "na1_c": 2.0, "pnto__R_c": 1.0, "na1_e": -2.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0}, "id": "PNTOt5", "gene_reaction_rule": "8884_AT1"}, {"subsystem": "Oxidative Phosphorylation", "name": "Inorganic diphosphatase", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PPA"]}, "metabolites": {"ppi_c": -1.0, "h2o_c": -1.0, "pi_c": 2.0, "h_c": 1.0}, "id": "PPA", "gene_reaction_rule": "5464_AT1"}, {"subsystem": "Others", "name": "Inorganic triphosphatase", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PPA2"]}, "metabolites": {"ppi_c": 1.0, "pppi_c": -1.0, "h2o_c": -1.0, "pi_c": 1.0, "h_c": 1.0}, "id": "PPA2", "gene_reaction_rule": ""}, {"subsystem": "Others", "name": "PPA2m", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PPA2m"]}, "metabolites": {"h2o_m": -1.0, "h_m": 1.0, "ppi_m": 1.0, "pi_m": 1.0, "pppi_m": -1.0}, "id": "PPA2m", "gene_reaction_rule": ""}, {"subsystem": "Triacylglycerol Synthesis", "name": "PPAP", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PPAP"]}, "metabolites": {"pa_hs_c": -1.0, "pi_c": 1.0, "h2o_c": -1.0, "dag_hs_c": 1.0}, "id": "PPAP", "gene_reaction_rule": "8612_AT1 or 8611_AT1 or 8613_AT1 or 8611_AT2"}, {"subsystem": "Miscellaneous", "name": "PPAer", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PPAer"]}, "metabolites": {"pi_r": 2.0, "ppi_r": -1.0, "h_r": 1.0, "h2o_r": -1.0}, "id": "PPAer", "gene_reaction_rule": "2538_AT1 or 92579_AT1 or 57818_AT1"}, {"subsystem": "Oxidative Phosphorylation", "name": "Inorganic diphosphatase", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PPAm"]}, "metabolites": {"ppi_m": -1.0, "h_m": 1.0, "h2o_m": -1.0, "pi_m": 2.0}, "id": "PPAm", "gene_reaction_rule": "27068_AT4 or 27068_AT1 or 27068_AT3 or 27068_AT2"}, {"subsystem": "Miscellaneous", "name": "PPAn", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PPAn"]}, "metabolites": {"h_n": 1.0, "h2o_n": -1.0, "pi_n": 2.0, "ppi_n": -1.0}, "id": "PPAn", "gene_reaction_rule": ""}, {"subsystem": "Transport, Extracellular", "name": "PPAtr", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PPAt"]}, "metabolites": {"ppa_c": 1.0, "ppa_e": -1.0}, "id": "PPAtr", "gene_reaction_rule": ""}, {"subsystem": "Transport, Mitochondrial", "name": "PPAtm", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PPAtm"]}, "metabolites": {"ppa_c": -1.0, "ppa_m": 1.0}, "id": "PPAtm", "gene_reaction_rule": ""}, {"subsystem": "Heme Biosynthesis", "name": "Porphobilinogen synthase", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PPBNGS"]}, "metabolites": {"ppbng_c": 1.0, "5aop_c": -2.0, "h_c": 1.0, "h2o_c": 2.0}, "id": "PPBNGS", "gene_reaction_rule": "210_AT1 or 210_AT2"}, {"subsystem": "CoA Biosynthesis", "name": "Phosphopantothenoylcysteine decarboxylase", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PPCDC"]}, "metabolites": {"pan4p_c": 1.0, "co2_c": 1.0, "4ppcys_c": -1.0, "h_c": -1.0}, "id": "PPCDC", "gene_reaction_rule": "60490_AT1"}, {"subsystem": "Valine, Leucine, and Isoleucine Metabolism", "name": "PPCOACm", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PPCOACm"]}, "metabolites": {"mmcoa__S_m": 1.0, "hco3_m": -1.0, "atp_m": -1.0, "adp_m": 1.0, "pi_m": 1.0, "ppcoa_m": -1.0, "h_m": 1.0}, "id": "PPCOACm", "gene_reaction_rule": "5096_AT1 and 5095_AT1"}, {"subsystem": "Propanoate Metabolism", "name": "PPCOAOm", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PPCOAOm"]}, "metabolites": {"ppcoa_m": -1.0, "fad_m": -1.0, "prpncoa_m": 1.0, "fadh2_m": 1.0}, "id": 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Metabolism", "name": "SQLSr", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["SQLSr"]}, "metabolites": {"h_r": -1.0, "nadp_r": 1.0, "frdp_r": -2.0, "ppi_r": 2.0, "sql_r": 1.0, "nadph_r": -1.0}, "id": "SQLSr", "gene_reaction_rule": "2222_AT1"}, {"subsystem": "Steroid Metabolism", "name": "SR5AR2r", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["SR5AR2r"]}, "metabolites": {"andrstndn_r": -1.0, "andrstandn_r": 1.0, "h_r": -1.0, "nadph_r": -1.0, "nadp_r": 1.0}, "id": "SR5AR2r", "gene_reaction_rule": "6715_AT1 or 6716_AT1"}, {"subsystem": "Steroid Metabolism", "name": "SR5ARr", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["SR5ARr"]}, "metabolites": {"h_r": -1.0, "nadp_r": 1.0, "tststerone_r": -1.0, "nadph_r": -1.0, "5adtststerone_r": 1.0}, "id": "SR5ARr", "gene_reaction_rule": "6716_AT1 or 6715_AT1"}, {"subsystem": "Tryptophan metabolism", "name": "SRTN23OX", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["SRTN23OX"]}, "metabolites": {"srtn_c": -1.0, "f5hoxkyn_c": 1.0, "o2_c": -1.0}, "id": "SRTN23OX", "gene_reaction_rule": "3620_AT1"}, {"subsystem": "Tryptophan metabolism", "name": "SRTNACT", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["SRTNACT"]}, "metabolites": {"srtn_c": -1.0, "coa_c": 1.0, "h_c": 1.0, "Nacsertn_c": 1.0, "accoa_c": -1.0}, "id": "SRTNACT", "gene_reaction_rule": "15_AT1"}, {"subsystem": "Tryptophan metabolism", "name": "SRTNMTX", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["SRTNMTX"]}, "metabolites": {"amet_c": -1.0, "ahcys_c": 1.0, "h_c": 1.0, "nmthsrtn_c": 1.0, "srtn_c": -1.0}, "id": "SRTNMTX", "gene_reaction_rule": "11185_AT1"}, {"subsystem": "Transport, Extracellular", "name": "SRTNt6 LPAREN 2 RPAREN r", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["SRTNt6_LPAREN_2_RPAREN_r"]}, "metabolites": {"srtn_c": 1.0, "srtn_e": -1.0, 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"6483_AT1"}, {"subsystem": "Sphingolipid Metabolism", "name": "ST3GAL22g", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ST3GAL22g"]}, "metabolites": {"cmpacna_g": -1.0, "h_g": 1.0, "gd1a_hs_g": 1.0, "cmp_g": 1.0, "gm1_hs_g": -1.0}, "id": "ST3GAL22g", "gene_reaction_rule": "6483_AT1"}, {"subsystem": "Sphingolipid Metabolism", "name": "ST3GAL23g", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ST3GAL23g"]}, "metabolites": {"cmpacna_g": -1.0, "h_g": 1.0, "gd1b_hs_g": -1.0, "cmp_g": 1.0, "gt1b_hs_g": 1.0}, "id": "ST3GAL23g", "gene_reaction_rule": "6483_AT1"}, {"subsystem": "Blood Group Biosynthesis", "name": "ST3GAL31g", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ST3GAL31g"]}, "metabolites": {"galacglcgalgluside_hs_g": -1.0, "h_g": 1.0, "cmp_g": 1.0, "cmpacna_g": -1.0, "acngalacglcgalgluside_hs_g": 1.0}, "id": "ST3GAL31g", "gene_reaction_rule": "6487_AT6 or 6487_AT11 or 6487_AT5 or 6487_AT7 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"id": "ST6GALNAC27", "gene_reaction_rule": "10610_AT1"}, {"subsystem": "Sphingolipid Metabolism", "name": "ST6GALNAC28", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ST6GALNAC28"]}, "metabolites": {"gp1c_hs_g": 1.0, "h_g": 1.0, "gq1c_hs_g": -1.0, "cmp_g": 1.0, "cmpacna_g": -1.0}, "id": "ST6GALNAC28", "gene_reaction_rule": "10610_AT1"}, {"subsystem": "Sphingolipid Metabolism", "name": "ST6GALNAC31", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ST6GALNAC31"]}, "metabolites": {"gm1b_hs_g": -1.0, "h_g": 1.0, "cmp_g": 1.0, "cmpacna_g": -1.0, "gd1alpha_hs_g": 1.0}, "id": "ST6GALNAC31", "gene_reaction_rule": "256435_AT1 or 30815_AT1 or 81849_AT1"}, {"subsystem": "Sphingolipid Metabolism", "name": "ST6GALNAC61", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ST6GALNAC61"]}, "metabolites": {"cmpacna_g": -1.0, "h_g": 1.0, "gd1a_hs_g": -1.0, "cmp_g": 1.0, "gt1alpha_hs_g": 1.0}, "id": "ST6GALNAC61", 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{"notes": {"original_bigg_ids": ["2629.4"]}, "name": "GBA", "id": "2629_AT4"}, {"notes": {"original_bigg_ids": ["2629.3"]}, "name": "GBA", "id": "2629_AT3"}, {"notes": {"original_bigg_ids": ["26301.1"]}, "name": "GBGT1", "id": "26301_AT1"}, {"notes": {"original_bigg_ids": ["4329.1"]}, "name": "ALDH6A1", "id": "4329_AT1"}, {"notes": {"original_bigg_ids": ["7915.1"]}, "name": "ALDH5A1", "id": "7915_AT1"}, {"notes": {"original_bigg_ids": ["7915.2"]}, "name": "ALDH5A1", "id": "7915_AT2"}, {"notes": {"original_bigg_ids": ["275.1"]}, "name": "AMT", "id": "275_AT1"}, {"notes": {"original_bigg_ids": ["2653.1"]}, "name": "GCSH", "id": "2653_AT1"}, {"notes": {"original_bigg_ids": ["2731.1"]}, "name": "GLDC", "id": "2731_AT1"}, {"notes": {"original_bigg_ids": ["2651.1"]}, "name": "GCNT2", "id": "2651_AT1"}, {"notes": {"original_bigg_ids": ["55343.1"]}, "name": "SLC35C1", "id": "55343_AT1"}, {"notes": {"original_bigg_ids": ["9945.1"]}, "name": "GFPT2", "id": "9945_AT1"}, {"notes": {"original_bigg_ids": ["2673.1"]}, "name": "GFPT1", "id": "2673_AT1"}, {"notes": {"original_bigg_ids": ["7264.1"]}, "name": "TSTA3", "id": "7264_AT1"}, {"notes": {"original_bigg_ids": ["8836.1"]}, "name": "GGH", "id": "8836_AT1"}, {"notes": {"original_bigg_ids": ["2655.1"]}, "name": "None", "id": "2655_AT1"}, {"notes": {"original_bigg_ids": ["2998.1"]}, "name": "GYS2", "id": "2998_AT1"}, {"notes": {"original_bigg_ids": ["8908.1"]}, "name": "GYG2", "id": "8908_AT1"}, {"notes": {"original_bigg_ids": ["2992.1"]}, "name": "GYG1", "id": "2992_AT1"}, {"notes": {"original_bigg_ids": ["2997.1"]}, "name": "GYS1", "id": "2997_AT1"}, {"notes": {"original_bigg_ids": ["2687.1"]}, "name": "GGT5", "id": "2687_AT1"}, {"notes": {"original_bigg_ids": ["6470.2"]}, "name": "SHMT1", "id": "6470_AT2"}, {"notes": {"original_bigg_ids": ["6470.1"]}, "name": "SHMT1", "id": "6470_AT1"}, {"notes": {"original_bigg_ids": ["6472.1"]}, "name": "SHMT2", "id": "6472_AT1"}, {"notes": {"original_bigg_ids": ["2717.1"]}, 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{"name": "Acetyl-CoA", "notes": {"original_bigg_ids": ["accoa_x"]}, "charge": 0, "formula": "C23H34N7O17P3S", "compartment": "x", "id": "accoa_x"}, {"name": "Acetoacetyl-CoA", "notes": {"original_bigg_ids": ["aacoa_x"]}, "charge": 0, "formula": "C25H36N7O18P3S", "compartment": "x", "id": "aacoa_x"}, {"name": "Coenzyme A", "notes": {"original_bigg_ids": ["coa_x"]}, "charge": 0, "formula": "C21H32N7O16P3S", "compartment": "x", "id": "coa_x"}, {"name": "Octanoyl-CoA (n-C8:0CoA)", "notes": {"original_bigg_ids": ["occoa_x"]}, "charge": 0, "formula": "C29H46N7O17P3S", "compartment": "x", "id": "occoa_x"}, {"name": "3-Oxodecanoyl-CoA", "notes": {"original_bigg_ids": ["3odcoa_x"]}, "charge": 0, "formula": "C31H48N7O18P3S", "compartment": "x", "id": "3odcoa_x"}, {"name": "3-Oxododecanoyl-CoA", "notes": {"original_bigg_ids": ["3oddcoa_x"]}, "charge": 0, "formula": "C33H52N7O18P3S", "compartment": "x", "id": "3oddcoa_x"}, {"name": "Decanoyl-CoA (n-C10:0CoA)", "notes": {"original_bigg_ids": 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10632_AT1 and 521_AT1 and 517_AT2) or (522_AT4 and 521_AT1 and 517_AT2 and 10632_AT1 and 4905_AT1 and 9551_AT3 and 10476_AT1 and 515_AT1) or (522_AT1 and 517_AT1 and 521_AT1 and 10632_AT1 and 9551_AT3 and 4905_AT1 and 10476_AT2 and 515_AT3) or (521_AT1 and 522_AT1 and 9551_AT1 and 10632_AT1 and 4905_AT1 and 518_AT3 and 515_AT1 and 10476_AT2) or (10632_AT1 and 515_AT2 and 521_AT1 and 517_AT2 and 10476_AT2 and 4905_AT1 and 9551_AT3 and 522_AT2) or (10476_AT1 and 515_AT1 and 522_AT2 and 4905_AT1 and 9551_AT2 and 10632_AT1 and 517_AT1 and 521_AT1) or (4905_AT1 and 516_AT2 and 10476_AT2 and 521_AT1 and 515_AT2 and 9551_AT1 and 522_AT3 and 10632_AT1) or (10632_AT1 and 9551_AT1 and 518_AT1 and 521_AT1 and 10476_AT2 and 515_AT3 and 522_AT2 and 4905_AT1) or (9551_AT1 and 10632_AT1 and 522_AT3 and 521_AT1 and 517_AT2 and 10476_AT2 and 515_AT1 and 4905_AT1) or (10476_AT1 and 4905_AT1 and 516_AT2 and 10632_AT1 and 522_AT3 and 9551_AT1 and 521_AT1 and 515_AT2) or (10476_AT1 and 516_AT2 and 4905_AT1 and 522_AT3 and 9551_AT2 and 10632_AT1 and 515_AT2 and 521_AT1) or (10632_AT1 and 522_AT4 and 515_AT2 and 521_AT1 and 518_AT3 and 10476_AT1 and 9551_AT3 and 4905_AT1) or (522_AT1 and 521_AT1 and 10632_AT1 and 9551_AT1 and 4905_AT1 and 10476_AT2 and 518_AT2 and 515_AT3) or (515_AT3 and 10476_AT1 and 516_AT2 and 4905_AT1 and 522_AT5 and 9551_AT2 and 10632_AT1 and 521_AT1) or (515_AT3 and 10476_AT2 and 4905_AT1 and 9551_AT3 and 10632_AT1 and 521_AT1 and 522_AT1 and 517_AT2) or (521_AT1 and 515_AT2 and 518_AT1 and 9551_AT1 and 10632_AT1 and 4905_AT1 and 522_AT5 and 10476_AT2) or (522_AT4 and 521_AT1 and 10632_AT1 and 9551_AT3 and 4905_AT1 and 10476_AT2 and 518_AT3 and 515_AT1) or (10476_AT2 and 516_AT1 and 515_AT3 and 4905_AT1 and 10632_AT1 and 9551_AT2 and 521_AT1 and 522_AT4) or (522_AT5 and 4905_AT1 and 10476_AT2 and 518_AT1 and 521_AT1 and 515_AT2 and 9551_AT2 and 10632_AT1) or (515_AT2 and 521_AT1 and 518_AT1 and 522_AT1 and 10632_AT1 and 4905_AT1 and 9551_AT3 and 10476_AT2) or (521_AT1 and 10632_AT1 and 4905_AT1 and 522_AT5 and 9551_AT3 and 518_AT2 and 515_AT1 and 10476_AT2) or (9551_AT2 and 522_AT3 and 10632_AT1 and 521_AT1 and 10476_AT1 and 515_AT1 and 518_AT3 and 4905_AT1) or (9551_AT2 and 10632_AT1 and 518_AT1 and 521_AT1 and 10476_AT2 and 515_AT3 and 522_AT2 and 4905_AT1) or (521_AT1 and 522_AT4 and 517_AT2 and 9551_AT1 and 10632_AT1 and 4905_AT1 and 515_AT3 and 10476_AT2) or (521_AT1 and 522_AT1 and 9551_AT1 and 10632_AT1 and 4905_AT1 and 515_AT3 and 10476_AT2 and 518_AT3) or (4905_AT1 and 10476_AT2 and 518_AT2 and 515_AT3 and 521_AT1 and 10632_AT1 and 522_AT3 and 9551_AT1) or (9551_AT3 and 4905_AT1 and 10476_AT2 and 515_AT1 and 518_AT2 and 522_AT1 and 521_AT1 and 10632_AT1) or (10632_AT1 and 521_AT1 and 515_AT2 and 522_AT4 and 518_AT1 and 10476_AT1 and 4905_AT1 and 9551_AT3) or (515_AT2 and 521_AT1 and 9551_AT1 and 10632_AT1 and 4905_AT1 and 522_AT5 and 516_AT1 and 10476_AT1) or (517_AT1 and 521_AT1 and 515_AT2 and 10632_AT1 and 9551_AT1 and 522_AT5 and 4905_AT1 and 10476_AT1) or (517_AT2 and 515_AT2 and 521_AT1 and 10632_AT1 and 9551_AT3 and 522_AT5 and 4905_AT1 and 10476_AT1) or (518_AT3 and 10476_AT2 and 4905_AT1 and 522_AT3 and 10632_AT1 and 9551_AT1 and 515_AT2 and 521_AT1) or (521_AT1 and 10632_AT1 and 4905_AT1 and 522_AT5 and 516_AT2 and 9551_AT3 and 10476_AT2 and 515_AT1) or (522_AT3 and 10632_AT1 and 521_AT1 and 10476_AT1 and 515_AT1 and 516_AT2 and 4905_AT1 and 9551_AT3) or (522_AT5 and 4905_AT1 and 10476_AT1 and 515_AT1 and 518_AT3 and 521_AT1 and 9551_AT1 and 10632_AT1) or (9551_AT2 and 522_AT3 and 10632_AT1 and 521_AT1 and 517_AT2 and 515_AT1 and 10476_AT2 and 4905_AT1) or (10476_AT2 and 515_AT3 and 522_AT2 and 9551_AT3 and 4905_AT1 and 10632_AT1 and 518_AT1 and 521_AT1) or (4905_AT1 and 9551_AT3 and 10476_AT1 and 515_AT2 and 521_AT1 and 517_AT2 and 522_AT3 and 10632_AT1) or (10476_AT2 and 9551_AT3 and 522_AT2 and 4905_AT1 and 10632_AT1 and 518_AT1 and 515_AT2 and 521_AT1) or (10476_AT1 and 515_AT3 and 4905_AT1 and 10632_AT1 and 9551_AT1 and 517_AT1 and 521_AT1 and 522_AT4) or (10632_AT1 and 9551_AT1 and 518_AT1 and 521_AT1 and 515_AT1 and 10476_AT1 and 522_AT5 and 4905_AT1) or (4905_AT1 and 522_AT5 and 10476_AT1 and 516_AT1 and 521_AT1 and 515_AT2 and 10632_AT1 and 9551_AT2) or (9551_AT3 and 4905_AT1 and 10476_AT1 and 515_AT3 and 518_AT2 and 522_AT1 and 521_AT1 and 10632_AT1) or (9551_AT2 and 10632_AT1 and 517_AT1 and 515_AT2 and 521_AT1 and 10476_AT2 and 4905_AT1 and 522_AT5) or (10476_AT1 and 515_AT3 and 4905_AT1 and 522_AT3 and 10632_AT1 and 9551_AT1 and 517_AT2 and 521_AT1) or (4905_AT1 and 9551_AT3 and 515_AT3 and 10476_AT1 and 522_AT4 and 521_AT1 and 517_AT1 and 10632_AT1) or (10632_AT1 and 521_AT1 and 515_AT3 and 518_AT3 and 10476_AT1 and 4905_AT1 and 522_AT5 and 9551_AT3) or (515_AT1 and 10476_AT2 and 9551_AT3 and 522_AT2 and 4905_AT1 and 10632_AT1 and 518_AT1 and 521_AT1) or (4905_AT1 and 522_AT5 and 516_AT1 and 10476_AT2 and 515_AT2 and 521_AT1 and 9551_AT2 and 10632_AT1) or (9551_AT3 and 4905_AT1 and 522_AT5 and 10476_AT1 and 515_AT3 and 518_AT1 and 521_AT1 and 10632_AT1) or (521_AT1 and 9551_AT2 and 10632_AT1 and 4905_AT1 and 522_AT2 and 518_AT2 and 515_AT1 and 10476_AT2) or (515_AT3 and 518_AT2 and 10476_AT2 and 522_AT5 and 4905_AT1 and 9551_AT2 and 10632_AT1 and 521_AT1) or (515_AT1 and 10476_AT1 and 9551_AT3 and 522_AT2 and 4905_AT1 and 10632_AT1 and 517_AT1 and 521_AT1) or (4905_AT1 and 522_AT2 and 9551_AT3 and 10476_AT1 and 515_AT2 and 521_AT1 and 517_AT1 and 10632_AT1) or (521_AT1 and 9551_AT2 and 10632_AT1 and 522_AT5 and 4905_AT1 and 10476_AT2 and 515_AT1 and 516_AT1) or (9551_AT1 and 10632_AT1 and 522_AT3 and 521_AT1 and 518_AT1 and 515_AT1 and 10476_AT1 and 4905_AT1) or (515_AT1 and 10476_AT2 and 516_AT1 and 4905_AT1 and 9551_AT3 and 10632_AT1 and 522_AT3 and 521_AT1) or (4905_AT1 and 10476_AT2 and 515_AT1 and 521_AT1 and 522_AT4 and 517_AT1 and 9551_AT1 and 10632_AT1) or (10476_AT1 and 516_AT1 and 4905_AT1 and 9551_AT2 and 522_AT3 and 10632_AT1 and 521_AT1 and 515_AT2) or (521_AT1 and 9551_AT1 and 10632_AT1 and 522_AT5 and 4905_AT1 and 515_AT1 and 10476_AT2 and 516_AT1) or (521_AT1 and 10632_AT1 and 9551_AT3 and 4905_AT1 and 522_AT5 and 516_AT1 and 10476_AT2 and 515_AT3) or (521_AT1 and 10632_AT1 and 522_AT3 and 9551_AT3 and 4905_AT1 and 518_AT3 and 10476_AT2 and 515_AT3) or (9551_AT2 and 10632_AT1 and 521_AT1 and 516_AT1 and 10476_AT2 and 515_AT3 and 522_AT2 and 4905_AT1) or (515_AT1 and 10476_AT1 and 4905_AT1 and 522_AT5 and 9551_AT1 and 10632_AT1 and 521_AT1 and 517_AT1) or (521_AT1 and 9551_AT2 and 10632_AT1 and 522_AT2 and 516_AT2 and 4905_AT1 and 10476_AT1 and 515_AT3) or (4905_AT1 and 516_AT2 and 515_AT3 and 10476_AT1 and 521_AT1 and 522_AT4 and 9551_AT1 and 10632_AT1) or (10476_AT1 and 515_AT1 and 9551_AT3 and 4905_AT1 and 516_AT2 and 10632_AT1 and 521_AT1 and 522_AT4) or (521_AT1 and 522_AT4 and 10632_AT1 and 9551_AT3 and 4905_AT1 and 10476_AT2 and 516_AT1 and 515_AT3) or (4905_AT1 and 518_AT2 and 10476_AT1 and 515_AT2 and 521_AT1 and 522_AT1 and 9551_AT2 and 10632_AT1) or (10632_AT1 and 521_AT1 and 522_AT4 and 518_AT1 and 515_AT1 and 10476_AT2 and 4905_AT1 and 9551_AT3) or (515_AT1 and 518_AT3 and 10476_AT2 and 4905_AT1 and 10632_AT1 and 9551_AT1 and 521_AT1 and 522_AT4) or (522_AT4 and 521_AT1 and 10632_AT1 and 9551_AT2 and 4905_AT1 and 10476_AT1 and 518_AT2 and 515_AT3) or (515_AT1 and 10476_AT2 and 4905_AT1 and 522_AT5 and 516_AT2 and 10632_AT1 and 9551_AT1 and 521_AT1) or (10632_AT1 and 9551_AT1 and 522_AT1 and 521_AT1 and 10476_AT2 and 515_AT1 and 516_AT1 and 4905_AT1) or (522_AT5 and 4905_AT1 and 9551_AT3 and 515_AT3 and 10476_AT2 and 521_AT1 and 517_AT2 and 10632_AT1) or (521_AT1 and 522_AT1 and 517_AT1 and 9551_AT1 and 10632_AT1 and 4905_AT1 and 515_AT1 and 10476_AT2) or (9551_AT3 and 4905_AT1 and 10476_AT2 and 518_AT2 and 515_AT3 and 521_AT1 and 522_AT3 and 10632_AT1) or (515_AT3 and 518_AT3 and 10476_AT1 and 4905_AT1 and 9551_AT2 and 522_AT3 and 10632_AT1 and 521_AT1) or (10476_AT2 and 518_AT2 and 515_AT3 and 9551_AT3 and 4905_AT1 and 522_AT5 and 10632_AT1 and 521_AT1) or (10632_AT1 and 521_AT1 and 517_AT2 and 515_AT1 and 10476_AT2 and 4905_AT1 and 9551_AT3 and 522_AT2) or (4905_AT1 and 516_AT2 and 10476_AT1 and 515_AT1 and 521_AT1 and 522_AT4 and 10632_AT1 and 9551_AT1) or (10476_AT2 and 4905_AT1 and 516_AT2 and 522_AT2 and 10632_AT1 and 9551_AT2 and 521_AT1 and 515_AT2) or (521_AT1 and 517_AT2 and 522_AT3 and 10632_AT1 and 4905_AT1 and 9551_AT3 and 515_AT3 and 10476_AT1) or (9551_AT2 and 10632_AT1 and 517_AT2 and 521_AT1 and 522_AT4 and 515_AT1 and 10476_AT2 and 4905_AT1) or (10476_AT2 and 522_AT5 and 4905_AT1 and 9551_AT1 and 10632_AT1 and 521_AT1 and 515_AT2 and 517_AT1) or (518_AT1 and 521_AT1 and 522_AT3 and 10632_AT1 and 9551_AT3 and 4905_AT1 and 10476_AT1 and 515_AT1) or (521_AT1 and 10632_AT1 and 4905_AT1 and 522_AT5 and 9551_AT3 and 515_AT1 and 518_AT3 and 10476_AT2) or (10476_AT2 and 515_AT1 and 4905_AT1 and 9551_AT3 and 522_AT3 and 10632_AT1 and 521_AT1 and 517_AT2) or (9551_AT2 and 10632_AT1 and 521_AT1 and 515_AT3 and 10476_AT1 and 518_AT3 and 4905_AT1 and 522_AT2) or (4905_AT1 and 515_AT1 and 10476_AT1 and 518_AT1 and 522_AT4 and 521_AT1 and 10632_AT1 and 9551_AT1) or (515_AT3 and 10476_AT1 and 4905_AT1 and 9551_AT3 and 10632_AT1 and 522_AT4 and 521_AT1 and 518_AT1) or (10632_AT1 and 518_AT1 and 521_AT1 and 10476_AT1 and 515_AT3 and 522_AT2 and 9551_AT3 and 4905_AT1) or (9551_AT2 and 10632_AT1 and 517_AT1 and 515_AT2 and 521_AT1 and 10476_AT1 and 522_AT2 and 4905_AT1) or (4905_AT1 and 522_AT5 and 518_AT2 and 10476_AT2 and 521_AT1 and 515_AT2 and 10632_AT1 and 9551_AT2) or (9551_AT2 and 522_AT3 and 10632_AT1 and 515_AT2 and 521_AT1 and 10476_AT2 and 516_AT2 and 4905_AT1) or (515_AT3 and 10476_AT1 and 516_AT1 and 4905_AT1 and 522_AT2 and 9551_AT1 and 10632_AT1 and 521_AT1) or (522_AT1 and 515_AT2 and 521_AT1 and 10632_AT1 and 9551_AT3 and 4905_AT1 and 516_AT1 and 10476_AT2) or (10476_AT1 and 4905_AT1 and 9551_AT3 and 522_AT3 and 10632_AT1 and 515_AT2 and 521_AT1 and 517_AT1) or (516_AT1 and 10476_AT1 and 515_AT1 and 4905_AT1 and 9551_AT2 and 10632_AT1 and 522_AT3 and 521_AT1) or (521_AT1 and 517_AT1 and 10632_AT1 and 9551_AT2 and 4905_AT1 and 522_AT5 and 515_AT1 and 10476_AT1) or (10476_AT1 and 4905_AT1 and 522_AT5 and 9551_AT1 and 10632_AT1 and 521_AT1 and 515_AT2 and 518_AT1) or (10476_AT1 and 9551_AT3 and 4905_AT1 and 522_AT5 and 516_AT2 and 10632_AT1 and 521_AT1 and 515_AT2) or (521_AT1 and 10632_AT1 and 516_AT2 and 4905_AT1 and 522_AT2 and 9551_AT3 and 515_AT3 and 10476_AT1) or (9551_AT1 and 10632_AT1 and 522_AT3 and 515_AT2 and 521_AT1 and 518_AT2 and 10476_AT2 and 4905_AT1) or (10476_AT1 and 515_AT3 and 4905_AT1 and 522_AT5 and 10632_AT1 and 9551_AT1 and 517_AT1 and 521_AT1) or (522_AT4 and 521_AT1 and 10632_AT1 and 4905_AT1 and 9551_AT3 and 518_AT2 and 515_AT3 and 10476_AT2) or (522_AT5 and 4905_AT1 and 518_AT3 and 10476_AT2 and 515_AT2 and 521_AT1 and 10632_AT1 and 9551_AT1) or (10476_AT2 and 516_AT2 and 4905_AT1 and 522_AT2 and 9551_AT3 and 10632_AT1 and 515_AT2 and 521_AT1) or (522_AT1 and 521_AT1 and 9551_AT2 and 10632_AT1 and 4905_AT1 and 516_AT2 and 515_AT1 and 10476_AT2) or (9551_AT2 and 10632_AT1 and 521_AT1 and 10476_AT1 and 515_AT3 and 518_AT2 and 522_AT5 and 4905_AT1) or (10632_AT1 and 521_AT1 and 516_AT1 and 10476_AT1 and 515_AT3 and 9551_AT3 and 522_AT2 and 4905_AT1) or (4905_AT1 and 10476_AT2 and 516_AT1 and 522_AT1 and 521_AT1 and 515_AT2 and 10632_AT1 and 9551_AT2) or (4905_AT1 and 515_AT1 and 10476_AT2 and 518_AT3 and 522_AT4 and 521_AT1 and 9551_AT2 and 10632_AT1) or (515_AT3 and 10476_AT2 and 4905_AT1 and 9551_AT3 and 10632_AT1 and 522_AT3 and 521_AT1 and 517_AT2) or (521_AT1 and 9551_AT1 and 10632_AT1 and 522_AT3 and 4905_AT1 and 515_AT3 and 10476_AT2 and 518_AT3) or (10632_AT1 and 518_AT1 and 521_AT1 and 515_AT2 and 10476_AT1 and 9551_AT3 and 4905_AT1 and 522_AT5) or (9551_AT3 and 522_AT2 and 4905_AT1 and 10476_AT2 and 515_AT3 and 518_AT2 and 521_AT1 and 10632_AT1) or (10632_AT1 and 521_AT1 and 522_AT1 and 516_AT1 and 515_AT1 and 10476_AT1 and 4905_AT1 and 9551_AT3) or (517_AT2 and 521_AT1 and 9551_AT2 and 10632_AT1 and 522_AT2 and 4905_AT1 and 515_AT1 and 10476_AT2) or (10632_AT1 and 9551_AT2 and 522_AT4 and 521_AT1 and 517_AT1 and 515_AT3 and 10476_AT2 and 4905_AT1) or (522_AT1 and 515_AT2 and 521_AT1 and 10632_AT1 and 9551_AT3 and 4905_AT1 and 10476_AT1 and 518_AT2) or (4905_AT1 and 522_AT2 and 518_AT2 and 515_AT3 and 10476_AT2 and 521_AT1 and 9551_AT1 and 10632_AT1) or (4905_AT1 and 522_AT2 and 9551_AT3 and 518_AT3 and 515_AT1 and 10476_AT2 and 521_AT1 and 10632_AT1) or (4905_AT1 and 515_AT3 and 10476_AT1 and 518_AT3 and 521_AT1 and 522_AT1 and 9551_AT1 and 10632_AT1) or (521_AT1 and 10632_AT1 and 522_AT2 and 9551_AT3 and 4905_AT1 and 516_AT2 and 10476_AT2 and 515_AT3) or (10632_AT1 and 9551_AT2 and 521_AT1 and 515_AT2 and 10476_AT1 and 516_AT1 and 4905_AT1 and 522_AT2) or (521_AT1 and 515_AT2 and 10632_AT1 and 522_AT2 and 9551_AT3 and 4905_AT1 and 10476_AT2 and 516_AT1) or (521_AT1 and 522_AT4 and 518_AT1 and 9551_AT1 and 10632_AT1 and 4905_AT1 and 515_AT3 and 10476_AT2) or (515_AT2 and 521_AT1 and 522_AT1 and 9551_AT1 and 10632_AT1 and 4905_AT1 and 518_AT3 and 10476_AT1) or (522_AT2 and 4905_AT1 and 10476_AT1 and 515_AT1 and 518_AT3 and 521_AT1 and 9551_AT2 and 10632_AT1) or (521_AT1 and 515_AT2 and 522_AT1 and 10632_AT1 and 4905_AT1 and 516_AT2 and 9551_AT3 and 10476_AT2) or (522_AT4 and 515_AT2 and 521_AT1 and 517_AT1 and 9551_AT2 and 10632_AT1 and 4905_AT1 and 10476_AT2) or (10476_AT1 and 515_AT1 and 522_AT2 and 4905_AT1 and 10632_AT1 and 9551_AT1 and 517_AT1 and 521_AT1) or (9551_AT3 and 4905_AT1 and 10476_AT2 and 515_AT3 and 518_AT1 and 521_AT1 and 522_AT4 and 10632_AT1) or (10476_AT2 and 515_AT3 and 4905_AT1 and 522_AT3 and 10632_AT1 and 9551_AT1 and 518_AT1 and 521_AT1) or (516_AT2 and 4905_AT1 and 10476_AT2 and 515_AT2 and 521_AT1 and 522_AT1 and 9551_AT1 and 10632_AT1) or (10476_AT2 and 518_AT2 and 4905_AT1 and 522_AT3 and 9551_AT2 and 10632_AT1 and 515_AT2 and 521_AT1) or (10476_AT1 and 4905_AT1 and 522_AT5 and 10632_AT1 and 9551_AT2 and 517_AT2 and 515_AT2 and 521_AT1) or (4905_AT1 and 522_AT2 and 9551_AT3 and 515_AT3 and 10476_AT2 and 521_AT1 and 517_AT2 and 10632_AT1) or (518_AT1 and 521_AT1 and 515_AT2 and 9551_AT2 and 10632_AT1 and 522_AT2 and 4905_AT1 and 10476_AT1) or (516_AT1 and 10476_AT2 and 515_AT1 and 9551_AT3 and 4905_AT1 and 10632_AT1 and 522_AT4 and 521_AT1) or (10476_AT1 and 4905_AT1 and 9551_AT2 and 10632_AT1 and 517_AT1 and 521_AT1 and 522_AT4 and 515_AT2) or (521_AT1 and 522_AT3 and 10632_AT1 and 4905_AT1 and 9551_AT3 and 515_AT3 and 518_AT2 and 10476_AT1) or (10476_AT1 and 9551_AT3 and 4905_AT1 and 516_AT2 and 522_AT3 and 10632_AT1 and 521_AT1 and 515_AT2) or (9551_AT3 and 4905_AT1 and 522_AT5 and 10476_AT2 and 515_AT3 and 517_AT1 and 521_AT1 and 10632_AT1) or (522_AT2 and 4905_AT1 and 516_AT1 and 10476_AT1 and 515_AT1 and 521_AT1 and 10632_AT1 and 9551_AT1) or (518_AT1 and 521_AT1 and 9551_AT2 and 522_AT3 and 10632_AT1 and 4905_AT1 and 515_AT1 and 10476_AT1) or (521_AT1 and 515_AT2 and 10632_AT1 and 4905_AT1 and 522_AT2 and 9551_AT3 and 518_AT3 and 10476_AT2) or (10476_AT1 and 4905_AT1 and 9551_AT2 and 10632_AT1 and 515_AT2 and 521_AT1 and 518_AT1 and 522_AT1) or (4905_AT1 and 515_AT1 and 10476_AT1 and 518_AT3 and 522_AT4 and 521_AT1 and 9551_AT2 and 10632_AT1) or (10476_AT2 and 515_AT1 and 522_AT2 and 4905_AT1 and 516_AT2 and 10632_AT1 and 9551_AT1 and 521_AT1) or (9551_AT2 and 10632_AT1 and 517_AT2 and 522_AT4 and 515_AT2 and 521_AT1 and 10476_AT2 and 4905_AT1) or (522_AT5 and 4905_AT1 and 518_AT3 and 10476_AT2 and 515_AT1 and 521_AT1 and 9551_AT1 and 10632_AT1) or (4905_AT1 and 522_AT2 and 518_AT3 and 10476_AT2 and 515_AT2 and 521_AT1 and 9551_AT2 and 10632_AT1) or (4905_AT1 and 10476_AT1 and 518_AT3 and 515_AT3 and 521_AT1 and 522_AT4 and 10632_AT1 and 9551_AT1) or (10632_AT1 and 9551_AT1 and 517_AT1 and 521_AT1 and 515_AT2 and 10476_AT1 and 522_AT2 and 4905_AT1) or (10632_AT1 and 9551_AT2 and 522_AT4 and 515_AT2 and 521_AT1 and 516_AT1 and 10476_AT2 and 4905_AT1) or (10476_AT1 and 9551_AT3 and 4905_AT1 and 10632_AT1 and 522_AT3 and 518_AT1 and 515_AT2 and 521_AT1) or (521_AT1 and 517_AT2 and 10632_AT1 and 4905_AT1 and 9551_AT3 and 522_AT2 and 515_AT1 and 10476_AT1) or (9551_AT2 and 522_AT3 and 10632_AT1 and 517_AT2 and 521_AT1 and 10476_AT2 and 515_AT3 and 4905_AT1) or (10476_AT2 and 515_AT1 and 518_AT3 and 9551_AT3 and 4905_AT1 and 10632_AT1 and 522_AT1 and 521_AT1) or (521_AT1 and 515_AT2 and 10632_AT1 and 522_AT5 and 4905_AT1 and 516_AT2 and 9551_AT3 and 10476_AT2) or (521_AT1 and 518_AT1 and 9551_AT1 and 10632_AT1 and 4905_AT1 and 522_AT2 and 515_AT3 and 10476_AT1) or (4905_AT1 and 518_AT2 and 515_AT1 and 10476_AT1 and 521_AT1 and 522_AT1 and 9551_AT1 and 10632_AT1) or (4905_AT1 and 522_AT2 and 515_AT3 and 10476_AT1 and 518_AT3 and 521_AT1 and 9551_AT1 and 10632_AT1) or (4905_AT1 and 522_AT2 and 515_AT3 and 10476_AT1 and 521_AT1 and 518_AT1 and 9551_AT2 and 10632_AT1) or (4905_AT1 and 10476_AT2 and 515_AT1 and 517_AT1 and 522_AT1 and 521_AT1 and 9551_AT2 and 10632_AT1) or (515_AT3 and 10476_AT1 and 4905_AT1 and 522_AT5 and 9551_AT2 and 10632_AT1 and 521_AT1 and 518_AT1) or (10632_AT1 and 522_AT4 and 521_AT1 and 10476_AT1 and 518_AT3 and 515_AT3 and 9551_AT3 and 4905_AT1) or (522_AT5 and 4905_AT1 and 10476_AT2 and 517_AT2 and 515_AT2 and 521_AT1 and 10632_AT1 and 9551_AT1) or (4905_AT1 and 516_AT1 and 10476_AT1 and 515_AT3 and 522_AT4 and 521_AT1 and 10632_AT1 and 9551_AT1) or (4905_AT1 and 10476_AT2 and 515_AT1 and 522_AT1 and 517_AT2 and 521_AT1 and 10632_AT1 and 9551_AT2) or (10632_AT1 and 521_AT1 and 522_AT4 and 518_AT2 and 515_AT1 and 10476_AT1 and 4905_AT1 and 9551_AT3) or (10476_AT1 and 518_AT2 and 4905_AT1 and 522_AT3 and 9551_AT2 and 10632_AT1 and 515_AT2 and 521_AT1) or (10632_AT1 and 521_AT1 and 10476_AT2 and 518_AT3 and 515_AT3 and 522_AT2 and 9551_AT3 and 4905_AT1) or (518_AT2 and 10476_AT1 and 4905_AT1 and 522_AT2 and 9551_AT2 and 10632_AT1 and 515_AT2 and 521_AT1) or (10632_AT1 and 521_AT1 and 10476_AT2 and 518_AT3 and 515_AT3 and 9551_AT3 and 4905_AT1 and 522_AT5) or (10476_AT2 and 4905_AT1 and 10632_AT1 and 9551_AT1 and 522_AT1 and 518_AT1 and 521_AT1 and 515_AT2) or (4905_AT1 and 10476_AT1 and 518_AT3 and 515_AT3 and 522_AT4 and 521_AT1 and 9551_AT2 and 10632_AT1) or (4905_AT1 and 515_AT3 and 10476_AT2 and 521_AT1 and 522_AT1 and 517_AT2 and 9551_AT1 and 10632_AT1) or (522_AT5 and 4905_AT1 and 516_AT2 and 10476_AT2 and 521_AT1 and 515_AT2 and 9551_AT1 and 10632_AT1) or (4905_AT1 and 522_AT5 and 10476_AT1 and 515_AT3 and 518_AT2 and 521_AT1 and 10632_AT1 and 9551_AT1) or (10476_AT2 and 515_AT3 and 9551_AT3 and 522_AT2 and 4905_AT1 and 10632_AT1 and 517_AT1 and 521_AT1) or (4905_AT1 and 522_AT2 and 9551_AT3 and 10476_AT1 and 521_AT1 and 515_AT2 and 517_AT2 and 10632_AT1) or (522_AT1 and 521_AT1 and 10632_AT1 and 9551_AT3 and 4905_AT1 and 515_AT1 and 10476_AT1 and 518_AT3) or (4905_AT1 and 9551_AT3 and 515_AT1 and 10476_AT2 and 521_AT1 and 517_AT2 and 522_AT1 and 10632_AT1) or (522_AT1 and 521_AT1 and 10632_AT1 and 9551_AT3 and 4905_AT1 and 516_AT2 and 10476_AT2 and 515_AT1) or (4905_AT1 and 516_AT1 and 10476_AT2 and 522_AT4 and 515_AT2 and 521_AT1 and 9551_AT1 and 10632_AT1) or (515_AT2 and 522_AT4 and 521_AT1 and 9551_AT1 and 10632_AT1 and 516_AT2 and 4905_AT1 and 10476_AT1) or (9551_AT1 and 10632_AT1 and 521_AT1 and 517_AT1 and 515_AT3 and 10476_AT1 and 4905_AT1 and 522_AT2) or (517_AT1 and 521_AT1 and 9551_AT2 and 10632_AT1 and 522_AT2 and 4905_AT1 and 10476_AT2 and 515_AT1) or (521_AT1 and 515_AT2 and 522_AT1 and 517_AT2 and 10632_AT1 and 4905_AT1 and 9551_AT3 and 10476_AT2) or (9551_AT1 and 10632_AT1 and 521_AT1 and 515_AT2 and 10476_AT1 and 4905_AT1 and 522_AT5 and 516_AT2) or (4905_AT1 and 518_AT3 and 10476_AT2 and 515_AT3 and 522_AT4 and 521_AT1 and 10632_AT1 and 9551_AT1) or (521_AT1 and 517_AT2 and 9551_AT2 and 10632_AT1 and 4905_AT1 and 522_AT5 and 515_AT3 and 10476_AT2) or (521_AT1 and 522_AT4 and 9551_AT1 and 10632_AT1 and 4905_AT1 and 515_AT3 and 10476_AT2 and 516_AT1) or (4905_AT1 and 10476_AT2 and 515_AT1 and 518_AT2 and 522_AT1 and 521_AT1 and 10632_AT1 and 9551_AT1) or (4905_AT1 and 10476_AT1 and 518_AT2 and 521_AT1 and 522_AT4 and 515_AT2 and 9551_AT2 and 10632_AT1) or (521_AT1 and 515_AT2 and 10632_AT1 and 522_AT3 and 4905_AT1 and 9551_AT3 and 518_AT3 and 10476_AT1) or (9551_AT1 and 10632_AT1 and 521_AT1 and 515_AT2 and 10476_AT2 and 4905_AT1 and 516_AT2 and 522_AT2) or (515_AT1 and 10476_AT1 and 4905_AT1 and 10632_AT1 and 9551_AT2 and 522_AT1 and 517_AT1 and 521_AT1) or (10632_AT1 and 522_AT1 and 515_AT2 and 521_AT1 and 10476_AT2 and 518_AT2 and 9551_AT3 and 4905_AT1) or (515_AT3 and 10476_AT1 and 4905_AT1 and 9551_AT3 and 10632_AT1 and 521_AT1 and 522_AT1 and 517_AT1) or (4905_AT1 and 516_AT2 and 10476_AT1 and 521_AT1 and 515_AT2 and 522_AT1 and 9551_AT2 and 10632_AT1) or (518_AT3 and 10476_AT1 and 4905_AT1 and 9551_AT1 and 10632_AT1 and 522_AT4 and 515_AT2 and 521_AT1) or (521_AT1 and 522_AT4 and 515_AT2 and 10632_AT1 and 9551_AT3 and 4905_AT1 and 516_AT2 and 10476_AT2) or (9551_AT3 and 4905_AT1 and 10476_AT1 and 516_AT1 and 521_AT1 and 515_AT2 and 10632_AT1 and 522_AT3) or (9551_AT3 and 4905_AT1 and 522_AT5 and 10476_AT2 and 518_AT1 and 521_AT1 and 515_AT2 and 10632_AT1) or (9551_AT3 and 4905_AT1 and 522_AT5 and 10476_AT1 and 517_AT1 and 515_AT2 and 521_AT1 and 10632_AT1) or (515_AT1 and 10476_AT1 and 522_AT5 and 4905_AT1 and 9551_AT2 and 10632_AT1 and 517_AT2 and 521_AT1) or (516_AT1 and 10476_AT2 and 4905_AT1 and 522_AT3 and 10632_AT1 and 9551_AT1 and 515_AT2 and 521_AT1) or (4905_AT1 and 9551_AT3 and 10476_AT2 and 521_AT1 and 515_AT2 and 517_AT2 and 522_AT3 and 10632_AT1) or (521_AT1 and 515_AT2 and 10632_AT1 and 9551_AT1 and 522_AT2 and 4905_AT1 and 10476_AT2 and 516_AT1) or (518_AT2 and 515_AT1 and 10476_AT2 and 4905_AT1 and 9551_AT2 and 10632_AT1 and 521_AT1 and 522_AT1) or (9551_AT1 and 10632_AT1 and 521_AT1 and 517_AT2 and 10476_AT2 and 515_AT1 and 4905_AT1 and 522_AT2) or (521_AT1 and 517_AT1 and 9551_AT1 and 522_AT3 and 10632_AT1 and 4905_AT1 and 515_AT3 and 10476_AT1) or (9551_AT3 and 4905_AT1 and 515_AT1 and 10476_AT2 and 518_AT2 and 522_AT4 and 521_AT1 and 10632_AT1) or (522_AT4 and 515_AT2 and 521_AT1 and 10632_AT1 and 9551_AT1 and 4905_AT1 and 518_AT3 and 10476_AT2) or (516_AT1 and 10476_AT2 and 4905_AT1 and 522_AT5 and 9551_AT1 and 10632_AT1 and 515_AT2 and 521_AT1) or (515_AT3 and 10476_AT2 and 4905_AT1 and 9551_AT2 and 10632_AT1 and 522_AT3 and 521_AT1 and 517_AT1) or (515_AT3 and 518_AT2 and 10476_AT1 and 4905_AT1 and 9551_AT1 and 10632_AT1 and 521_AT1 and 522_AT1) or (10476_AT1 and 515_AT1 and 4905_AT1 and 10632_AT1 and 522_AT3 and 9551_AT1 and 517_AT1 and 521_AT1) or (10632_AT1 and 515_AT2 and 521_AT1 and 516_AT1 and 10476_AT2 and 522_AT5 and 4905_AT1 and 9551_AT3) or (521_AT1 and 10632_AT1 and 522_AT2 and 9551_AT3 and 4905_AT1 and 516_AT1 and 515_AT1 and 10476_AT2) or (10632_AT1 and 521_AT1 and 517_AT1 and 515_AT3 and 10476_AT1 and 4905_AT1 and 522_AT2 and 9551_AT3) or (9551_AT2 and 10632_AT1 and 517_AT1 and 521_AT1 and 10476_AT2 and 515_AT1 and 4905_AT1 and 522_AT5) or (522_AT1 and 521_AT1 and 10632_AT1 and 9551_AT1 and 4905_AT1 and 516_AT1 and 10476_AT1 and 515_AT1) or (10476_AT1 and 515_AT1 and 518_AT3 and 4905_AT1 and 522_AT5 and 9551_AT2 and 10632_AT1 and 521_AT1) or (515_AT3 and 516_AT1 and 10476_AT1 and 4905_AT1 and 9551_AT3 and 10632_AT1 and 522_AT4 and 521_AT1) or (10632_AT1 and 522_AT1 and 521_AT1 and 10476_AT1 and 515_AT1 and 518_AT2 and 9551_AT3 and 4905_AT1) or (522_AT3 and 10632_AT1 and 521_AT1 and 515_AT2 and 10476_AT2 and 518_AT2 and 9551_AT3 and 4905_AT1) or (10632_AT1 and 9551_AT2 and 522_AT3 and 517_AT2 and 521_AT1 and 10476_AT1 and 515_AT3 and 4905_AT1) or (521_AT1 and 10632_AT1 and 9551_AT1 and 522_AT5 and 4905_AT1 and 10476_AT2 and 515_AT3 and 518_AT2) or (10632_AT1 and 9551_AT1 and 517_AT1 and 521_AT1 and 522_AT4 and 10476_AT1 and 515_AT1 and 4905_AT1) or (518_AT3 and 10476_AT2 and 515_AT3 and 4905_AT1 and 522_AT5 and 10632_AT1 and 9551_AT1 and 521_AT1) or (4905_AT1 and 10476_AT1 and 515_AT3 and 517_AT1 and 522_AT1 and 521_AT1 and 9551_AT2 and 10632_AT1) or (521_AT1 and 9551_AT1 and 522_AT3 and 10632_AT1 and 4905_AT1 and 515_AT3 and 516_AT1 and 10476_AT2) or (10476_AT1 and 4905_AT1 and 10632_AT1 and 9551_AT1 and 522_AT1 and 518_AT1 and 521_AT1 and 515_AT2) or (4905_AT1 and 515_AT3 and 10476_AT1 and 521_AT1 and 517_AT2 and 522_AT1 and 9551_AT2 and 10632_AT1) or (9551_AT3 and 4905_AT1 and 516_AT1 and 515_AT1 and 10476_AT1 and 522_AT4 and 521_AT1 and 10632_AT1) or (521_AT1 and 517_AT1 and 10632_AT1 and 9551_AT2 and 4905_AT1 and 522_AT2 and 515_AT3 and 10476_AT1) or (521_AT1 and 522_AT3 and 9551_AT2 and 10632_AT1 and 516_AT2 and 4905_AT1 and 10476_AT2 and 515_AT3) or (10632_AT1 and 521_AT1 and 522_AT4 and 10476_AT1 and 518_AT3 and 515_AT1 and 4905_AT1 and 9551_AT3) or (10476_AT2 and 518_AT2 and 4905_AT1 and 10632_AT1 and 9551_AT1 and 522_AT1 and 515_AT2 and 521_AT1) or (10632_AT1 and 522_AT3 and 9551_AT1 and 517_AT1 and 521_AT1 and 515_AT2 and 10476_AT2 and 4905_AT1) or (521_AT1 and 10632_AT1 and 522_AT3 and 9551_AT1 and 4905_AT1 and 10476_AT1 and 516_AT1 and 515_AT3) or (9551_AT2 and 522_AT3 and 10632_AT1 and 521_AT1 and 515_AT2 and 517_AT2 and 10476_AT2 and 4905_AT1) or (515_AT2 and 521_AT1 and 517_AT2 and 9551_AT1 and 522_AT3 and 10632_AT1 and 4905_AT1 and 10476_AT1) or (10476_AT2 and 515_AT3 and 9551_AT3 and 4905_AT1 and 10632_AT1 and 517_AT1 and 522_AT4 and 521_AT1) or (515_AT3 and 10476_AT2 and 4905_AT1 and 516_AT2 and 9551_AT1 and 522_AT3 and 10632_AT1 and 521_AT1) or (521_AT1 and 10632_AT1 and 4905_AT1 and 522_AT2 and 9551_AT3 and 516_AT1 and 10476_AT1 and 515_AT1) or (9551_AT2 and 10632_AT1 and 521_AT1 and 522_AT1 and 515_AT3 and 518_AT3 and 10476_AT1 and 4905_AT1) or (515_AT3 and 10476_AT2 and 4905_AT1 and 9551_AT2 and 10632_AT1 and 521_AT1 and 522_AT1 and 517_AT1) or (521_AT1 and 522_AT3 and 10632_AT1 and 4905_AT1 and 9551_AT3 and 518_AT3 and 10476_AT2 and 515_AT1) or (10632_AT1 and 9551_AT1 and 521_AT1 and 522_AT4 and 10476_AT1 and 515_AT1 and 518_AT2 and 4905_AT1) or (515_AT3 and 10476_AT2 and 522_AT5 and 4905_AT1 and 516_AT2 and 9551_AT3 and 10632_AT1 and 521_AT1) or (9551_AT2 and 10632_AT1 and 522_AT1 and 517_AT2 and 521_AT1 and 10476_AT2 and 515_AT3 and 4905_AT1) or (9551_AT2 and 10632_AT1 and 521_AT1 and 522_AT4 and 515_AT1 and 10476_AT1 and 4905_AT1 and 516_AT2) or (521_AT1 and 517_AT1 and 9551_AT1 and 10632_AT1 and 4905_AT1 and 522_AT5 and 515_AT3 and 10476_AT2) or (517_AT1 and 522_AT1 and 515_AT2 and 521_AT1 and 9551_AT2 and 10632_AT1 and 4905_AT1 and 10476_AT1) or (521_AT1 and 10632_AT1 and 9551_AT1 and 522_AT2 and 4905_AT1 and 10476_AT1 and 515_AT1 and 518_AT2) or (10476_AT2 and 515_AT1 and 4905_AT1 and 10632_AT1 and 522_AT3 and 9551_AT1 and 517_AT1 and 521_AT1) or (521_AT1 and 522_AT1 and 518_AT1 and 10632_AT1 and 4905_AT1 and 9551_AT3 and 515_AT3 and 10476_AT1) or (10476_AT2 and 515_AT1 and 9551_AT3 and 4905_AT1 and 522_AT3 and 10632_AT1 and 517_AT1 and 521_AT1) or (10632_AT1 and 9551_AT1 and 517_AT2 and 522_AT1 and 515_AT2 and 521_AT1 and 10476_AT2 and 4905_AT1) or (521_AT1 and 515_AT2 and 517_AT2 and 9551_AT1 and 10632_AT1 and 4905_AT1 and 522_AT5 and 10476_AT1) or (4905_AT1 and 515_AT1 and 10476_AT1 and 517_AT1 and 521_AT1 and 10632_AT1 and 9551_AT2 and 522_AT3) or (4905_AT1 and 516_AT2 and 9551_AT3 and 522_AT2 and 10476_AT1 and 521_AT1 and 515_AT2 and 10632_AT1) or (522_AT5 and 4905_AT1 and 10476_AT1 and 518_AT1 and 515_AT2 and 521_AT1 and 10632_AT1 and 9551_AT2) or (517_AT1 and 521_AT1 and 10632_AT1 and 9551_AT3 and 522_AT5 and 4905_AT1 and 515_AT1 and 10476_AT2) or (4905_AT1 and 522_AT2 and 518_AT3 and 515_AT1 and 10476_AT2 and 521_AT1 and 9551_AT2 and 10632_AT1) or (10476_AT2 and 4905_AT1 and 522_AT2 and 9551_AT1 and 10632_AT1 and 515_AT2 and 521_AT1 and 518_AT1) or (521_AT1 and 522_AT4 and 9551_AT2 and 10632_AT1 and 4905_AT1 and 516_AT2 and 10476_AT2 and 515_AT1) or (4905_AT1 and 10476_AT1 and 517_AT1 and 521_AT1 and 515_AT2 and 10632_AT1 and 9551_AT2 and 522_AT3) or (522_AT3 and 10632_AT1 and 521_AT1 and 515_AT2 and 518_AT3 and 10476_AT2 and 9551_AT3 and 4905_AT1) or (516_AT1 and 10476_AT1 and 515_AT3 and 9551_AT3 and 4905_AT1 and 522_AT3 and 10632_AT1 and 521_AT1) or (4905_AT1 and 515_AT1 and 10476_AT1 and 518_AT3 and 522_AT1 and 521_AT1 and 10632_AT1 and 9551_AT2) or (10476_AT1 and 516_AT2 and 4905_AT1 and 9551_AT3 and 10632_AT1 and 515_AT2 and 522_AT4 and 521_AT1) or (515_AT3 and 10476_AT1 and 4905_AT1 and 9551_AT1 and 10632_AT1 and 522_AT4 and 521_AT1 and 518_AT1) or (522_AT4 and 521_AT1 and 9551_AT2 and 10632_AT1 and 4905_AT1 and 515_AT3 and 518_AT3 and 10476_AT2) or (515_AT1 and 10476_AT1 and 9551_AT3 and 4905_AT1 and 10632_AT1 and 522_AT1 and 518_AT1 and 521_AT1) or (4905_AT1 and 518_AT3 and 10476_AT1 and 521_AT1 and 515_AT2 and 9551_AT2 and 522_AT3 and 10632_AT1) or (10476_AT2 and 4905_AT1 and 522_AT5 and 10632_AT1 and 9551_AT2 and 517_AT2 and 515_AT2 and 521_AT1) or (515_AT3 and 10476_AT1 and 4905_AT1 and 516_AT2 and 10632_AT1 and 9551_AT2 and 521_AT1 and 522_AT4) or (4905_AT1 and 515_AT3 and 10476_AT2 and 518_AT3 and 521_AT1 and 9551_AT2 and 522_AT3 and 10632_AT1) or (9551_AT2 and 10632_AT1 and 518_AT1 and 522_AT1 and 521_AT1 and 10476_AT2 and 515_AT3 and 4905_AT1) or (522_AT3 and 10632_AT1 and 515_AT2 and 521_AT1 and 518_AT1 and 10476_AT2 and 4905_AT1 and 9551_AT3) or (521_AT1 and 9551_AT2 and 10632_AT1 and 522_AT3 and 516_AT2 and 4905_AT1 and 515_AT1 and 10476_AT2) or (515_AT3 and 10476_AT1 and 4905_AT1 and 516_AT2 and 9551_AT1 and 10632_AT1 and 521_AT1 and 522_AT1) or (518_AT2 and 10476_AT1 and 4905_AT1 and 522_AT2 and 9551_AT1 and 10632_AT1 and 521_AT1 and 515_AT2) or (10476_AT2 and 515_AT1 and 522_AT2 and 9551_AT3 and 4905_AT1 and 10632_AT1 and 517_AT1 and 521_AT1) or (9551_AT2 and 10632_AT1 and 521_AT1 and 517_AT1 and 515_AT3 and 10476_AT2 and 522_AT5 and 4905_AT1) or (521_AT1 and 515_AT2 and 518_AT1 and 9551_AT1 and 10632_AT1 and 4905_AT1 and 522_AT2 and 10476_AT1) or (9551_AT2 and 10632_AT1 and 522_AT3 and 518_AT1 and 521_AT1 and 515_AT2 and 10476_AT1 and 4905_AT1) or (521_AT1 and 9551_AT1 and 10632_AT1 and 522_AT3 and 516_AT2 and 4905_AT1 and 10476_AT1 and 515_AT1) or (10476_AT2 and 515_AT1 and 4905_AT1 and 10632_AT1 and 9551_AT2 and 518_AT1 and 522_AT4 and 521_AT1) or (10476_AT1 and 515_AT3 and 522_AT2 and 516_AT2 and 4905_AT1 and 10632_AT1 and 9551_AT1 and 521_AT1) or (521_AT1 and 522_AT1 and 9551_AT1 and 10632_AT1 and 4905_AT1 and 515_AT3 and 10476_AT1 and 516_AT1) or (515_AT1 and 10476_AT1 and 518_AT2 and 9551_AT3 and 4905_AT1 and 522_AT3 and 10632_AT1 and 521_AT1) or (521_AT1 and 515_AT2 and 522_AT3 and 10632_AT1 and 9551_AT1 and 4905_AT1 and 10476_AT1 and 516_AT1) or (522_AT4 and 515_AT2 and 521_AT1 and 9551_AT2 and 10632_AT1 and 4905_AT1 and 516_AT1 and 10476_AT1) or (521_AT1 and 522_AT3 and 10632_AT1 and 9551_AT1 and 4905_AT1 and 515_AT1 and 10476_AT2 and 518_AT3) or (521_AT1 and 522_AT3 and 9551_AT2 and 10632_AT1 and 4905_AT1 and 518_AT2 and 515_AT1 and 10476_AT1) or (10476_AT1 and 515_AT1 and 518_AT2 and 4905_AT1 and 10632_AT1 and 522_AT3 and 9551_AT1 and 521_AT1) or (516_AT1 and 10476_AT2 and 4905_AT1 and 9551_AT3 and 10632_AT1 and 522_AT3 and 515_AT2 and 521_AT1) or (4905_AT1 and 522_AT2 and 516_AT1 and 515_AT1 and 10476_AT2 and 521_AT1 and 9551_AT2 and 10632_AT1) or (521_AT1 and 515_AT2 and 10632_AT1 and 522_AT3 and 4905_AT1 and 516_AT2 and 9551_AT3 and 10476_AT2) or (522_AT1 and 521_AT1 and 10632_AT1 and 9551_AT2 and 4905_AT1 and 516_AT1 and 10476_AT1 and 515_AT3) or (10632_AT1 and 9551_AT2 and 515_AT2 and 521_AT1 and 517_AT1 and 10476_AT2 and 4905_AT1 and 522_AT2) or (521_AT1 and 515_AT2 and 9551_AT1 and 522_AT3 and 10632_AT1 and 4905_AT1 and 10476_AT1 and 518_AT3) or (4905_AT1 and 10476_AT1 and 521_AT1 and 515_AT2 and 517_AT1 and 9551_AT1 and 522_AT3 and 10632_AT1) or (10632_AT1 and 522_AT1 and 517_AT2 and 521_AT1 and 515_AT1 and 10476_AT1 and 9551_AT3 and 4905_AT1) or (521_AT1 and 9551_AT2 and 10632_AT1 and 522_AT2 and 4905_AT1 and 516_AT1 and 515_AT1 and 10476_AT1) or (9551_AT1 and 522_AT3 and 10632_AT1 and 521_AT1 and 515_AT3 and 10476_AT1 and 516_AT2 and 4905_AT1) or (10632_AT1 and 522_AT3 and 517_AT1 and 521_AT1 and 10476_AT2 and 515_AT3 and 9551_AT3 and 4905_AT1) or (515_AT1 and 10476_AT1 and 4905_AT1 and 9551_AT2 and 522_AT3 and 10632_AT1 and 517_AT2 and 521_AT1) or (4905_AT1 and 10476_AT2 and 515_AT1 and 517_AT2 and 522_AT1 and 521_AT1 and 10632_AT1 and 9551_AT1) or (4905_AT1 and 522_AT2 and 515_AT3 and 10476_AT2 and 521_AT1 and 517_AT1 and 9551_AT1 and 10632_AT1) or (9551_AT1 and 10632_AT1 and 521_AT1 and 522_AT4 and 515_AT2 and 517_AT2 and 10476_AT1 and 4905_AT1) or (10476_AT2 and 4905_AT1 and 522_AT2 and 10632_AT1 and 9551_AT2 and 521_AT1 and 515_AT2 and 518_AT1) or (517_AT1 and 521_AT1 and 515_AT2 and 522_AT3 and 10632_AT1 and 9551_AT3 and 4905_AT1 and 10476_AT2) or (515_AT1 and 10476_AT1 and 516_AT2 and 4905_AT1 and 522_AT5 and 9551_AT3 and 10632_AT1 and 521_AT1) or (515_AT2 and 521_AT1 and 517_AT1 and 522_AT1 and 10632_AT1 and 4905_AT1 and 9551_AT3 and 10476_AT2) or (521_AT1 and 522_AT3 and 10632_AT1 and 9551_AT1 and 4905_AT1 and 518_AT3 and 10476_AT1 and 515_AT3) or (10476_AT1 and 9551_AT3 and 4905_AT1 and 10632_AT1 and 517_AT2 and 521_AT1 and 515_AT2 and 522_AT4) or (522_AT3 and 10632_AT1 and 521_AT1 and 10476_AT2 and 515_AT3 and 9551_AT3 and 4905_AT1 and 516_AT2) or (521_AT1 and 515_AT2 and 522_AT1 and 10632_AT1 and 9551_AT2 and 4905_AT1 and 10476_AT1 and 518_AT3) or (9551_AT1 and 522_AT3 and 10632_AT1 and 521_AT1 and 515_AT2 and 518_AT1 and 10476_AT1 and 4905_AT1) or (4905_AT1 and 518_AT3 and 10476_AT2 and 521_AT1 and 515_AT2 and 9551_AT2 and 10632_AT1 and 522_AT3) or (517_AT2 and 522_AT4 and 515_AT2 and 521_AT1 and 10632_AT1 and 9551_AT3 and 4905_AT1 and 10476_AT2) or (517_AT2 and 522_AT4 and 521_AT1 and 9551_AT2 and 10632_AT1 and 4905_AT1 and 515_AT1 and 10476_AT1) or (10476_AT2 and 515_AT1 and 516_AT2 and 4905_AT1 and 522_AT2 and 9551_AT2 and 10632_AT1 and 521_AT1) or (518_AT2 and 10476_AT1 and 515_AT1 and 4905_AT1 and 522_AT5 and 9551_AT3 and 10632_AT1 and 521_AT1) or (518_AT1 and 522_AT1 and 521_AT1 and 10632_AT1 and 9551_AT2 and 4905_AT1 and 515_AT1 and 10476_AT2) or (521_AT1 and 10632_AT1 and 9551_AT2 and 4905_AT1 and 522_AT2 and 515_AT3 and 518_AT2 and 10476_AT1) or (4905_AT1 and 10476_AT2 and 515_AT1 and 517_AT1 and 522_AT4 and 521_AT1 and 9551_AT2 and 10632_AT1) or (4905_AT1 and 522_AT2 and 10476_AT2 and 515_AT2 and 521_AT1 and 517_AT2 and 9551_AT1 and 10632_AT1) or (515_AT3 and 10476_AT2 and 4905_AT1 and 522_AT5 and 9551_AT1 and 10632_AT1 and 521_AT1 and 517_AT2) or (521_AT1 and 515_AT2 and 522_AT4 and 10632_AT1 and 4905_AT1 and 9551_AT3 and 10476_AT2 and 516_AT1) or (515_AT1 and 10476_AT1 and 522_AT5 and 4905_AT1 and 9551_AT2 and 10632_AT1 and 518_AT1 and 521_AT1) or (521_AT1 and 10632_AT1 and 9551_AT2 and 522_AT5 and 4905_AT1 and 516_AT2 and 10476_AT1 and 515_AT1) or (522_AT1 and 521_AT1 and 515_AT2 and 10632_AT1 and 9551_AT1 and 4905_AT1 and 516_AT2 and 10476_AT1) or (10476_AT2 and 515_AT3 and 4905_AT1 and 522_AT3 and 10632_AT1 and 9551_AT1 and 517_AT2 and 521_AT1) or (521_AT1 and 522_AT4 and 517_AT1 and 9551_AT2 and 10632_AT1 and 4905_AT1 and 515_AT3 and 10476_AT1) or (522_AT2 and 9551_AT3 and 4905_AT1 and 515_AT1 and 10476_AT2 and 518_AT2 and 521_AT1 and 10632_AT1) or (9551_AT3 and 4905_AT1 and 516_AT1 and 10476_AT2 and 515_AT1 and 522_AT1 and 521_AT1 and 10632_AT1) or (9551_AT3 and 4905_AT1 and 10476_AT1 and 518_AT2 and 521_AT1 and 522_AT4 and 515_AT2 and 10632_AT1) or (9551_AT3 and 516_AT2 and 4905_AT1 and 515_AT1 and 10476_AT1 and 522_AT1 and 521_AT1 and 10632_AT1) or (521_AT1 and 9551_AT2 and 522_AT3 and 10632_AT1 and 4905_AT1 and 515_AT3 and 516_AT1 and 10476_AT1) or (522_AT5 and 4905_AT1 and 515_AT1 and 10476_AT2 and 521_AT1 and 518_AT1 and 9551_AT1 and 10632_AT1) or (515_AT3 and 10476_AT1 and 4905_AT1 and 9551_AT2 and 10632_AT1 and 522_AT4 and 521_AT1 and 517_AT2) or (4905_AT1 and 10476_AT2 and 518_AT3 and 521_AT1 and 515_AT2 and 522_AT1 and 9551_AT2 and 10632_AT1) or (521_AT1 and 9551_AT1 and 10632_AT1 and 4905_AT1 and 516_AT2 and 522_AT2 and 10476_AT1 and 515_AT1) or (522_AT3 and 10632_AT1 and 9551_AT1 and 517_AT2 and 515_AT2 and 521_AT1 and 10476_AT2 and 4905_AT1) or (9551_AT3 and 4905_AT1 and 522_AT5 and 10476_AT2 and 515_AT1 and 516_AT1 and 521_AT1 and 10632_AT1) or (522_AT3 and 10632_AT1 and 521_AT1 and 518_AT1 and 515_AT3 and 10476_AT1 and 4905_AT1 and 9551_AT3) or (517_AT1 and 521_AT1 and 10632_AT1 and 9551_AT2 and 522_AT2 and 4905_AT1 and 10476_AT2 and 515_AT3) or (10476_AT1 and 515_AT3 and 516_AT2 and 522_AT5 and 4905_AT1 and 10632_AT1 and 9551_AT1 and 521_AT1) or (10632_AT1 and 522_AT3 and 521_AT1 and 518_AT1 and 515_AT1 and 10476_AT2 and 4905_AT1 and 9551_AT3) or (10476_AT1 and 515_AT3 and 4905_AT1 and 10632_AT1 and 9551_AT1 and 518_AT1 and 522_AT1 and 521_AT1) or (10632_AT1 and 515_AT2 and 521_AT1 and 518_AT1 and 10476_AT1 and 4905_AT1 and 522_AT2 and 9551_AT3) or (4905_AT1 and 518_AT2 and 10476_AT2 and 515_AT1 and 521_AT1 and 522_AT4 and 10632_AT1 and 9551_AT2) or (521_AT1 and 517_AT1 and 522_AT1 and 9551_AT1 and 10632_AT1 and 4905_AT1 and 515_AT3 and 10476_AT1) or (515_AT3 and 518_AT2 and 10476_AT1 and 4905_AT1 and 9551_AT1 and 10632_AT1 and 522_AT3 and 521_AT1) or (522_AT5 and 4905_AT1 and 516_AT2 and 10476_AT2 and 515_AT1 and 521_AT1 and 9551_AT2 and 10632_AT1) or (521_AT1 and 518_AT1 and 522_AT1 and 9551_AT1 and 10632_AT1 and 4905_AT1 and 515_AT1 and 10476_AT1) or (9551_AT1 and 10632_AT1 and 521_AT1 and 515_AT2 and 518_AT3 and 10476_AT1 and 4905_AT1 and 522_AT5) or (10476_AT2 and 515_AT3 and 516_AT2 and 4905_AT1 and 10632_AT1 and 9551_AT1 and 522_AT4 and 521_AT1) or (515_AT3 and 518_AT3 and 10476_AT1 and 4905_AT1 and 9551_AT3 and 10632_AT1 and 521_AT1 and 522_AT1) or (10476_AT2 and 515_AT1 and 522_AT2 and 4905_AT1 and 10632_AT1 and 9551_AT1 and 518_AT1 and 521_AT1) or (521_AT1 and 10632_AT1 and 9551_AT2 and 4905_AT1 and 522_AT5 and 516_AT2 and 10476_AT2 and 515_AT3) or (522_AT5 and 4905_AT1 and 9551_AT3 and 10476_AT2 and 515_AT2 and 521_AT1 and 517_AT1 and 10632_AT1) or (4905_AT1 and 522_AT2 and 518_AT2 and 10476_AT2 and 521_AT1 and 515_AT2 and 9551_AT2 and 10632_AT1) or (515_AT3 and 10476_AT2 and 522_AT5 and 4905_AT1 and 10632_AT1 and 9551_AT2 and 521_AT1 and 518_AT1) or (518_AT3 and 10476_AT2 and 515_AT3 and 522_AT2 and 4905_AT1 and 9551_AT2 and 10632_AT1 and 521_AT1) or (4905_AT1 and 10476_AT1 and 515_AT1 and 522_AT1 and 517_AT2 and 521_AT1 and 10632_AT1 and 9551_AT1) or (9551_AT1 and 10632_AT1 and 522_AT4 and 515_AT2 and 521_AT1 and 10476_AT2 and 516_AT2 and 4905_AT1) or (9551_AT2 and 10632_AT1 and 521_AT1 and 522_AT1 and 515_AT3 and 518_AT2 and 10476_AT2 and 4905_AT1) or (10476_AT2 and 518_AT3 and 4905_AT1 and 522_AT5 and 9551_AT2 and 10632_AT1 and 515_AT2 and 521_AT1) or (518_AT1 and 521_AT1 and 522_AT3 and 10632_AT1 and 9551_AT3 and 4905_AT1 and 10476_AT2 and 515_AT3) or (10476_AT1 and 515_AT3 and 4905_AT1 and 10632_AT1 and 9551_AT1 and 522_AT1 and 517_AT2 and 521_AT1) or (4905_AT1 and 10476_AT1 and 515_AT1 and 521_AT1 and 522_AT4 and 518_AT1 and 9551_AT2 and 10632_AT1) or (522_AT3 and 10632_AT1 and 521_AT1 and 517_AT1 and 515_AT3 and 10476_AT1 and 4905_AT1 and 9551_AT3) or (515_AT3 and 10476_AT1 and 4905_AT1 and 516_AT2 and 9551_AT2 and 10632_AT1 and 521_AT1 and 522_AT1) or (4905_AT1 and 10476_AT2 and 515_AT2 and 521_AT1 and 517_AT1 and 522_AT1 and 10632_AT1 and 9551_AT2) or (10476_AT2 and 518_AT2 and 4905_AT1 and 10632_AT1 and 9551_AT1 and 521_AT1 and 522_AT4 and 515_AT2) or (10632_AT1 and 9551_AT2 and 522_AT4 and 521_AT1 and 518_AT1 and 515_AT3 and 10476_AT2 and 4905_AT1) or (4905_AT1 and 522_AT2 and 9551_AT3 and 518_AT2 and 10476_AT1 and 515_AT1 and 521_AT1 and 10632_AT1) or (515_AT2 and 522_AT4 and 521_AT1 and 9551_AT2 and 10632_AT1 and 4905_AT1 and 518_AT3 and 10476_AT2) or (4905_AT1 and 10476_AT1 and 515_AT1 and 517_AT1 and 522_AT1 and 521_AT1 and 10632_AT1 and 9551_AT1) or (4905_AT1 and 10476_AT2 and 515_AT1 and 518_AT1 and 521_AT1 and 9551_AT2 and 522_AT3 and 10632_AT1) or (522_AT2 and 9551_AT3 and 4905_AT1 and 518_AT3 and 10476_AT1 and 515_AT2 and 521_AT1 and 10632_AT1) or (518_AT1 and 521_AT1 and 515_AT2 and 522_AT4 and 10632_AT1 and 9551_AT2 and 4905_AT1 and 10476_AT2) or (522_AT2 and 4905_AT1 and 515_AT1 and 10476_AT2 and 518_AT3 and 521_AT1 and 10632_AT1 and 9551_AT1) or (4905_AT1 and 522_AT5 and 10476_AT1 and 516_AT1 and 515_AT3 and 521_AT1 and 9551_AT2 and 10632_AT1) or (515_AT2 and 521_AT1 and 517_AT1 and 522_AT1 and 10632_AT1 and 4905_AT1 and 9551_AT3 and 10476_AT1) or (9551_AT3 and 4905_AT1 and 518_AT3 and 10476_AT2 and 515_AT3 and 522_AT1 and 521_AT1 and 10632_AT1) or (10632_AT1 and 521_AT1 and 517_AT1 and 515_AT3 and 10476_AT1 and 4905_AT1 and 522_AT5 and 9551_AT3) or (521_AT1 and 522_AT3 and 10632_AT1 and 9551_AT3 and 4905_AT1 and 518_AT3 and 10476_AT1 and 515_AT3) or (521_AT1 and 515_AT2 and 9551_AT2 and 10632_AT1 and 4905_AT1 and 522_AT5 and 516_AT2 and 10476_AT2) or (10476_AT1 and 515_AT1 and 518_AT3 and 4905_AT1 and 9551_AT1 and 10632_AT1 and 522_AT4 and 521_AT1) or (515_AT3 and 10476_AT1 and 4905_AT1 and 522_AT2 and 9551_AT1 and 10632_AT1 and 521_AT1 and 517_AT2) or (4905_AT1 and 10476_AT1 and 517_AT1 and 522_AT1 and 515_AT2 and 521_AT1 and 10632_AT1 and 9551_AT1) or (10476_AT2 and 4905_AT1 and 9551_AT1 and 10632_AT1 and 521_AT1 and 515_AT2 and 522_AT1 and 517_AT1) or (4905_AT1 and 515_AT3 and 10476_AT1 and 521_AT1 and 518_AT1 and 522_AT3 and 9551_AT2 and 10632_AT1) or (4905_AT1 and 9551_AT3 and 518_AT2 and 515_AT1 and 10476_AT2 and 521_AT1 and 522_AT3 and 10632_AT1) or (4905_AT1 and 10476_AT2 and 515_AT3 and 517_AT1 and 521_AT1 and 522_AT4 and 10632_AT1 and 9551_AT1) or (515_AT3 and 10476_AT1 and 4905_AT1 and 522_AT5 and 9551_AT1 and 10632_AT1 and 521_AT1 and 517_AT2) or (9551_AT2 and 10632_AT1 and 517_AT1 and 522_AT4 and 521_AT1 and 515_AT1 and 10476_AT1 and 4905_AT1) or (10632_AT1 and 521_AT1 and 518_AT1 and 515_AT3 and 10476_AT2 and 4905_AT1 and 522_AT5 and 9551_AT3) or (10632_AT1 and 521_AT1 and 10476_AT2 and 515_AT1 and 516_AT2 and 4905_AT1 and 522_AT2 and 9551_AT3) or (10476_AT2 and 518_AT3 and 4905_AT1 and 9551_AT3 and 10632_AT1 and 521_AT1 and 515_AT2 and 522_AT1) or (10476_AT2 and 522_AT2 and 4905_AT1 and 10632_AT1 and 9551_AT2 and 517_AT2 and 521_AT1 and 515_AT2) or (515_AT1 and 10476_AT1 and 4905_AT1 and 9551_AT2 and 10632_AT1 and 517_AT2 and 522_AT1 and 521_AT1) or (10476_AT2 and 515_AT1 and 516_AT1 and 4905_AT1 and 10632_AT1 and 9551_AT2 and 522_AT3 and 521_AT1) or (10632_AT1 and 522_AT4 and 521_AT1 and 515_AT3 and 518_AT2 and 10476_AT1 and 4905_AT1 and 9551_AT3) or (518_AT2 and 10476_AT2 and 515_AT1 and 4905_AT1 and 10632_AT1 and 9551_AT2 and 522_AT3 and 521_AT1) or (9551_AT1 and 10632_AT1 and 521_AT1 and 522_AT1 and 515_AT1 and 10476_AT2 and 4905_AT1 and 516_AT2) or (521_AT1 and 10632_AT1 and 522_AT3 and 4905_AT1 and 516_AT2 and 9551_AT3 and 515_AT3 and 10476_AT1) or (518_AT3 and 10476_AT1 and 522_AT2 and 4905_AT1 and 10632_AT1 and 9551_AT1 and 521_AT1 and 515_AT2) or (522_AT5 and 4905_AT1 and 10476_AT1 and 515_AT3 and 517_AT1 and 521_AT1 and 10632_AT1 and 9551_AT2) or (518_AT1 and 522_AT4 and 515_AT2 and 521_AT1 and 10632_AT1 and 9551_AT3 and 4905_AT1 and 10476_AT2) or (522_AT1 and 515_AT2 and 521_AT1 and 10632_AT1 and 9551_AT1 and 4905_AT1 and 516_AT1 and 10476_AT1) or (516_AT2 and 4905_AT1 and 9551_AT3 and 515_AT1 and 10476_AT2 and 521_AT1 and 10632_AT1 and 522_AT3) or (10476_AT2 and 518_AT2 and 9551_AT3 and 4905_AT1 and 522_AT5 and 10632_AT1 and 515_AT2 and 521_AT1) or (10476_AT1 and 516_AT2 and 4905_AT1 and 9551_AT3 and 10632_AT1 and 515_AT2 and 521_AT1 and 522_AT1) or (10632_AT1 and 517_AT1 and 522_AT4 and 515_AT2 and 521_AT1 and 10476_AT1 and 9551_AT3 and 4905_AT1) or (522_AT1 and 521_AT1 and 10632_AT1 and 9551_AT3 and 4905_AT1 and 516_AT1 and 10476_AT1 and 515_AT3) or (10632_AT1 and 521_AT1 and 515_AT2 and 522_AT4 and 10476_AT1 and 516_AT1 and 9551_AT3 and 4905_AT1) or (9551_AT2 and 10632_AT1 and 515_AT2 and 521_AT1 and 518_AT2 and 10476_AT1 and 4905_AT1 and 522_AT5) or (10476_AT1 and 515_AT3 and 4905_AT1 and 10632_AT1 and 9551_AT1 and 517_AT2 and 522_AT4 and 521_AT1) or (4905_AT1 and 518_AT2 and 10476_AT2 and 515_AT1 and 521_AT1 and 9551_AT1 and 10632_AT1 and 522_AT3) or (516_AT2 and 4905_AT1 and 515_AT3 and 10476_AT2 and 521_AT1 and 522_AT1 and 9551_AT2 and 10632_AT1) or (4905_AT1 and 522_AT5 and 9551_AT3 and 518_AT2 and 10476_AT1 and 515_AT2 and 521_AT1 and 10632_AT1) or (516_AT2 and 4905_AT1 and 10476_AT2 and 522_AT4 and 515_AT2 and 521_AT1 and 9551_AT2 and 10632_AT1) or (4905_AT1 and 522_AT5 and 10476_AT2 and 515_AT1 and 521_AT1 and 517_AT2 and 9551_AT1 and 10632_AT1) or (515_AT3 and 516_AT1 and 10476_AT2 and 4905_AT1 and 9551_AT2 and 522_AT3 and 10632_AT1 and 521_AT1) or (9551_AT1 and 522_AT3 and 10632_AT1 and 521_AT1 and 515_AT1 and 10476_AT1 and 518_AT3 and 4905_AT1) or (522_AT1 and 518_AT1 and 521_AT1 and 10632_AT1 and 9551_AT3 and 4905_AT1 and 10476_AT2 and 515_AT3) or (521_AT1 and 515_AT2 and 518_AT1 and 9551_AT2 and 522_AT3 and 10632_AT1 and 4905_AT1 and 10476_AT2) or (521_AT1 and 10632_AT1 and 9551_AT1 and 4905_AT1 and 522_AT5 and 10476_AT2 and 515_AT1 and 518_AT2) or (10632_AT1 and 9551_AT1 and 517_AT2 and 522_AT4 and 521_AT1 and 10476_AT1 and 515_AT1 and 4905_AT1) or (521_AT1 and 10632_AT1 and 522_AT3 and 9551_AT1 and 516_AT2 and 4905_AT1 and 10476_AT2 and 515_AT1) or (517_AT1 and 522_AT4 and 521_AT1 and 10632_AT1 and 9551_AT3 and 4905_AT1 and 515_AT1 and 10476_AT1) or (521_AT1 and 9551_AT1 and 10632_AT1 and 4905_AT1 and 522_AT2 and 515_AT1 and 518_AT3 and 10476_AT1) or (10632_AT1 and 9551_AT1 and 518_AT1 and 521_AT1 and 10476_AT1 and 515_AT1 and 522_AT2 and 4905_AT1) or (10632_AT1 and 9551_AT1 and 522_AT4 and 521_AT1 and 515_AT1 and 10476_AT2 and 516_AT2 and 4905_AT1) or (522_AT3 and 10632_AT1 and 517_AT2 and 521_AT1 and 10476_AT1 and 515_AT1 and 9551_AT3 and 4905_AT1) or (10476_AT1 and 515_AT3 and 4905_AT1 and 522_AT3 and 10632_AT1 and 9551_AT1 and 518_AT1 and 521_AT1) or (4905_AT1 and 522_AT5 and 515_AT3 and 10476_AT2 and 521_AT1 and 518_AT1 and 9551_AT1 and 10632_AT1) or (10476_AT1 and 4905_AT1 and 10632_AT1 and 9551_AT1 and 518_AT1 and 515_AT2 and 522_AT4 and 521_AT1) or (517_AT1 and 521_AT1 and 10632_AT1 and 9551_AT3 and 4905_AT1 and 522_AT5 and 515_AT1 and 10476_AT1) or (515_AT1 and 10476_AT2 and 9551_AT3 and 4905_AT1 and 10632_AT1 and 518_AT1 and 522_AT1 and 521_AT1) or (9551_AT3 and 4905_AT1 and 10476_AT2 and 517_AT1 and 521_AT1 and 522_AT4 and 515_AT2 and 10632_AT1) or (10476_AT1 and 4905_AT1 and 522_AT2 and 9551_AT2 and 10632_AT1 and 515_AT2 and 521_AT1 and 517_AT2) or (518_AT1 and 521_AT1 and 9551_AT2 and 522_AT3 and 10632_AT1 and 4905_AT1 and 10476_AT2 and 515_AT3) or (522_AT3 and 10632_AT1 and 9551_AT1 and 517_AT1 and 521_AT1 and 10476_AT2 and 515_AT3 and 4905_AT1) or (522_AT4 and 521_AT1 and 10632_AT1 and 4905_AT1 and 9551_AT3 and 515_AT3 and 518_AT3 and 10476_AT2) or (10476_AT1 and 515_AT3 and 518_AT2 and 4905_AT1 and 10632_AT1 and 9551_AT1 and 521_AT1 and 522_AT4) or (521_AT1 and 9551_AT1 and 10632_AT1 and 4905_AT1 and 522_AT2 and 515_AT3 and 10476_AT2 and 516_AT1) or (10632_AT1 and 517_AT1 and 522_AT4 and 521_AT1 and 10476_AT2 and 515_AT1 and 9551_AT3 and 4905_AT1) or (10632_AT1 and 522_AT4 and 521_AT1 and 10476_AT1 and 515_AT3 and 9551_AT3 and 516_AT2 and 4905_AT1) or (9551_AT2 and 10632_AT1 and 515_AT2 and 521_AT1 and 518_AT3 and 10476_AT1 and 522_AT2 and 4905_AT1) or (9551_AT1 and 10632_AT1 and 515_AT2 and 521_AT1 and 522_AT1 and 518_AT2 and 10476_AT1 and 4905_AT1) or (9551_AT1 and 10632_AT1 and 515_AT2 and 522_AT4 and 521_AT1 and 517_AT1 and 10476_AT2 and 4905_AT1) or (10476_AT2 and 4905_AT1 and 9551_AT1 and 10632_AT1 and 522_AT4 and 515_AT2 and 521_AT1 and 517_AT2) or (4905_AT1 and 522_AT5 and 10476_AT2 and 515_AT1 and 521_AT1 and 517_AT2 and 9551_AT2 and 10632_AT1) or (518_AT2 and 515_AT1 and 10476_AT1 and 4905_AT1 and 522_AT2 and 9551_AT2 and 10632_AT1 and 521_AT1) or (10632_AT1 and 9551_AT2 and 515_AT2 and 521_AT1 and 516_AT1 and 10476_AT2 and 522_AT2 and 4905_AT1) or (521_AT1 and 522_AT1 and 9551_AT2 and 10632_AT1 and 4905_AT1 and 518_AT2 and 10476_AT1 and 515_AT1) or (9551_AT1 and 10632_AT1 and 521_AT1 and 515_AT3 and 518_AT2 and 10476_AT1 and 4905_AT1 and 522_AT2) or (515_AT1 and 10476_AT1 and 522_AT2 and 4905_AT1 and 9551_AT2 and 10632_AT1 and 518_AT1 and 521_AT1) or (4905_AT1 and 10476_AT2 and 518_AT2 and 515_AT3 and 521_AT1 and 522_AT4 and 9551_AT2 and 10632_AT1) or (516_AT2 and 4905_AT1 and 522_AT2 and 515_AT3 and 10476_AT2 and 521_AT1 and 9551_AT2 and 10632_AT1) or (9551_AT2 and 10632_AT1 and 522_AT1 and 521_AT1 and 516_AT1 and 10476_AT1 and 515_AT1 and 4905_AT1) or (515_AT2 and 522_AT4 and 521_AT1 and 10632_AT1 and 4905_AT1 and 9551_AT3 and 518_AT2 and 10476_AT2) or (4905_AT1 and 522_AT5 and 9551_AT3 and 10476_AT2 and 515_AT1 and 521_AT1 and 518_AT1 and 10632_AT1) or (4905_AT1 and 522_AT2 and 10476_AT2 and 518_AT3 and 515_AT2 and 521_AT1 and 9551_AT1 and 10632_AT1) or (522_AT1 and 521_AT1 and 9551_AT2 and 10632_AT1 and 4905_AT1 and 10476_AT2 and 518_AT3 and 515_AT1) or (4905_AT1 and 522_AT5 and 518_AT2 and 10476_AT1 and 515_AT1 and 521_AT1 and 9551_AT1 and 10632_AT1) or (518_AT1 and 522_AT1 and 521_AT1 and 515_AT2 and 10632_AT1 and 9551_AT3 and 4905_AT1 and 10476_AT1) or (4905_AT1 and 515_AT1 and 10476_AT1 and 516_AT1 and 521_AT1 and 522_AT4 and 10632_AT1 and 9551_AT1) or (9551_AT2 and 10632_AT1 and 521_AT1 and 522_AT1 and 518_AT2 and 515_AT3 and 10476_AT1 and 4905_AT1) or (4905_AT1 and 515_AT1 and 10476_AT1 and 521_AT1 and 517_AT2 and 9551_AT1 and 522_AT3 and 10632_AT1) or (10476_AT2 and 516_AT1 and 4905_AT1 and 10632_AT1 and 9551_AT1 and 522_AT1 and 521_AT1 and 515_AT2) or (10476_AT1 and 4905_AT1 and 522_AT2 and 9551_AT1 and 10632_AT1 and 521_AT1 and 515_AT2 and 517_AT2) or (4905_AT1 and 516_AT2 and 9551_AT3 and 515_AT3 and 10476_AT2 and 521_AT1 and 522_AT4 and 10632_AT1) or (4905_AT1 and 522_AT5 and 516_AT1 and 515_AT1 and 10476_AT1 and 521_AT1 and 10632_AT1 and 9551_AT1) or (10476_AT2 and 516_AT1 and 515_AT3 and 9551_AT3 and 522_AT2 and 4905_AT1 and 10632_AT1 and 521_AT1) or (9551_AT1 and 10632_AT1 and 521_AT1 and 522_AT4 and 518_AT1 and 10476_AT2 and 515_AT1 and 4905_AT1) or (521_AT1 and 9551_AT1 and 10632_AT1 and 4905_AT1 and 522_AT5 and 516_AT2 and 10476_AT1 and 515_AT1) or (521_AT1 and 9551_AT1 and 10632_AT1 and 4905_AT1 and 522_AT2 and 515_AT3 and 10476_AT2 and 518_AT3) or (4905_AT1 and 522_AT2 and 9551_AT3 and 516_AT1 and 10476_AT1 and 515_AT2 and 521_AT1 and 10632_AT1) or (515_AT3 and 516_AT1 and 10476_AT1 and 4905_AT1 and 522_AT2 and 10632_AT1 and 9551_AT2 and 521_AT1) or (516_AT1 and 10476_AT1 and 9551_AT3 and 522_AT5 and 4905_AT1 and 10632_AT1 and 515_AT2 and 521_AT1) or (10476_AT1 and 4905_AT1 and 9551_AT2 and 10632_AT1 and 518_AT1 and 515_AT2 and 522_AT4 and 521_AT1) or (9551_AT3 and 4905_AT1 and 522_AT5 and 10476_AT1 and 518_AT3 and 521_AT1 and 515_AT2 and 10632_AT1) or (9551_AT2 and 10632_AT1 and 521_AT1 and 515_AT3 and 518_AT3 and 10476_AT2 and 522_AT5 and 4905_AT1) or (4905_AT1 and 515_AT3 and 10476_AT1 and 521_AT1 and 518_AT1 and 522_AT1 and 9551_AT2 and 10632_AT1) or (4905_AT1 and 10476_AT1 and 517_AT2 and 515_AT2 and 521_AT1 and 522_AT3 and 9551_AT2 and 10632_AT1) or (4905_AT1 and 10476_AT1 and 515_AT3 and 518_AT2 and 521_AT1 and 522_AT3 and 9551_AT2 and 10632_AT1) or (517_AT2 and 521_AT1 and 10632_AT1 and 9551_AT3 and 522_AT5 and 4905_AT1 and 10476_AT1 and 515_AT3) or (522_AT5 and 4905_AT1 and 10476_AT2 and 518_AT2 and 521_AT1 and 515_AT2 and 10632_AT1 and 9551_AT1) or (10632_AT1 and 9551_AT1 and 517_AT1 and 521_AT1 and 515_AT1 and 10476_AT2 and 4905_AT1 and 522_AT5) or (521_AT1 and 10632_AT1 and 9551_AT1 and 522_AT2 and 4905_AT1 and 515_AT1 and 10476_AT2 and 518_AT2) or (10476_AT1 and 515_AT1 and 4905_AT1 and 516_AT2 and 522_AT2 and 9551_AT2 and 10632_AT1 and 521_AT1) or (4905_AT1 and 10476_AT2 and 515_AT3 and 517_AT1 and 522_AT1 and 521_AT1 and 10632_AT1 and 9551_AT1) or (516_AT2 and 522_AT5 and 4905_AT1 and 10476_AT2 and 515_AT3 and 521_AT1 and 10632_AT1 and 9551_AT1) or (518_AT3 and 10476_AT2 and 515_AT3 and 4905_AT1 and 9551_AT2 and 10632_AT1 and 522_AT1 and 521_AT1) or (515_AT3 and 10476_AT1 and 4905_AT1 and 10632_AT1 and 9551_AT2 and 522_AT4 and 521_AT1 and 518_AT1) or (10476_AT1 and 518_AT3 and 9551_AT3 and 4905_AT1 and 10632_AT1 and 522_AT1 and 515_AT2 and 521_AT1) or (4905_AT1 and 522_AT2 and 10476_AT2 and 521_AT1 and 515_AT2 and 517_AT1 and 9551_AT1 and 10632_AT1) or (10632_AT1 and 521_AT1 and 516_AT1 and 10476_AT1 and 515_AT1 and 4905_AT1 and 522_AT5 and 9551_AT3) or (10632_AT1 and 521_AT1 and 517_AT2 and 515_AT3 and 10476_AT1 and 4905_AT1 and 9551_AT3 and 522_AT2) or (521_AT1 and 522_AT4 and 517_AT2 and 10632_AT1 and 4905_AT1 and 9551_AT3 and 10476_AT2 and 515_AT1) or (10476_AT1 and 516_AT1 and 4905_AT1 and 522_AT2 and 9551_AT1 and 10632_AT1 and 521_AT1 and 515_AT2) or (10632_AT1 and 9551_AT1 and 521_AT1 and 515_AT2 and 10476_AT2 and 518_AT2 and 522_AT2 and 4905_AT1) or (521_AT1 and 10632_AT1 and 9551_AT1 and 522_AT2 and 4905_AT1 and 516_AT2 and 10476_AT2 and 515_AT3) or (516_AT1 and 10476_AT2 and 515_AT1 and 4905_AT1 and 9551_AT2 and 10632_AT1 and 521_AT1 and 522_AT1) or (10632_AT1 and 521_AT1 and 517_AT1 and 522_AT1 and 10476_AT1 and 515_AT1 and 4905_AT1 and 9551_AT3) or (10476_AT1 and 522_AT2 and 4905_AT1 and 516_AT2 and 10632_AT1 and 9551_AT1 and 521_AT1 and 515_AT2) or (10632_AT1 and 521_AT1 and 522_AT1 and 517_AT2 and 515_AT3 and 10476_AT1 and 4905_AT1 and 9551_AT3) or (516_AT2 and 4905_AT1 and 10476_AT1 and 515_AT1 and 521_AT1 and 522_AT1 and 9551_AT2 and 10632_AT1) or (10476_AT1 and 4905_AT1 and 522_AT5 and 9551_AT2 and 10632_AT1 and 517_AT1 and 515_AT2 and 521_AT1) or (10476_AT1 and 4905_AT1 and 9551_AT1 and 10632_AT1 and 521_AT1 and 515_AT2 and 522_AT4 and 517_AT1) or (521_AT1 and 522_AT3 and 10632_AT1 and 4905_AT1 and 9551_AT3 and 518_AT3 and 10476_AT1 and 515_AT1) or (521_AT1 and 515_AT2 and 522_AT1 and 517_AT2 and 9551_AT1 and 10632_AT1 and 4905_AT1 and 10476_AT1) or (4905_AT1 and 10476_AT2 and 516_AT1 and 515_AT3 and 522_AT1 and 521_AT1 and 10632_AT1 and 9551_AT1) or (10476_AT1 and 518_AT2 and 522_AT2 and 9551_AT3 and 4905_AT1 and 10632_AT1 and 515_AT2 and 521_AT1) or (10476_AT2 and 4905_AT1 and 9551_AT1 and 10632_AT1 and 515_AT2 and 522_AT4 and 521_AT1 and 518_AT1) or (4905_AT1 and 9551_AT3 and 515_AT1 and 10476_AT1 and 521_AT1 and 522_AT4 and 518_AT1 and 10632_AT1) or (10476_AT2 and 515_AT3 and 4905_AT1 and 516_AT2 and 10632_AT1 and 9551_AT2 and 521_AT1 and 522_AT4) or (4905_AT1 and 516_AT1 and 515_AT1 and 10476_AT1 and 522_AT4 and 521_AT1 and 9551_AT2 and 10632_AT1) or (522_AT1 and 521_AT1 and 10632_AT1 and 9551_AT3 and 4905_AT1 and 10476_AT2 and 515_AT3 and 518_AT2) or (10632_AT1 and 9551_AT2 and 521_AT1 and 518_AT2 and 515_AT3 and 10476_AT2 and 4905_AT1 and 522_AT2) or (4905_AT1 and 522_AT2 and 515_AT3 and 10476_AT1 and 521_AT1 and 517_AT2 and 9551_AT2 and 10632_AT1) or (515_AT3 and 10476_AT2 and 4905_AT1 and 9551_AT3 and 10632_AT1 and 522_AT4 and 521_AT1 and 517_AT2) or (10476_AT2 and 518_AT3 and 4905_AT1 and 9551_AT1 and 10632_AT1 and 521_AT1 and 515_AT2 and 522_AT1) or (522_AT5 and 4905_AT1 and 9551_AT3 and 518_AT2 and 515_AT3 and 10476_AT1 and 521_AT1 and 10632_AT1) or (9551_AT1 and 10632_AT1 and 521_AT1 and 522_AT1 and 515_AT1 and 10476_AT1 and 518_AT3 and 4905_AT1) or (521_AT1 and 515_AT2 and 522_AT1 and 517_AT2 and 10632_AT1 and 4905_AT1 and 9551_AT3 and 10476_AT1) or (9551_AT2 and 10632_AT1 and 517_AT2 and 521_AT1 and 10476_AT2 and 515_AT3 and 522_AT2 and 4905_AT1) or (515_AT3 and 518_AT2 and 10476_AT1 and 4905_AT1 and 522_AT2 and 9551_AT3 and 10632_AT1 and 521_AT1) or (515_AT3 and 10476_AT2 and 516_AT2 and 4905_AT1 and 9551_AT3 and 10632_AT1 and 521_AT1 and 522_AT1) or (521_AT1 and 515_AT2 and 517_AT2 and 10632_AT1 and 522_AT5 and 4905_AT1 and 9551_AT3 and 10476_AT2) or (522_AT3 and 10632_AT1 and 9551_AT1 and 521_AT1 and 515_AT1 and 10476_AT2 and 516_AT1 and 4905_AT1) or (521_AT1 and 10632_AT1 and 4905_AT1 and 516_AT2 and 9551_AT3 and 522_AT2 and 10476_AT1 and 515_AT1) or (522_AT5 and 4905_AT1 and 10476_AT1 and 515_AT1 and 521_AT1 and 517_AT2 and 9551_AT1 and 10632_AT1) or (521_AT1 and 9551_AT2 and 10632_AT1 and 522_AT5 and 4905_AT1 and 516_AT1 and 10476_AT2 and 515_AT3) or (517_AT2 and 521_AT1 and 9551_AT2 and 10632_AT1 and 522_AT2 and 4905_AT1 and 10476_AT1 and 515_AT1) or (515_AT1 and 10476_AT2 and 4905_AT1 and 9551_AT3 and 10632_AT1 and 521_AT1 and 517_AT1 and 522_AT1) or (10632_AT1 and 9551_AT1 and 521_AT1 and 515_AT2 and 10476_AT1 and 518_AT2 and 522_AT5 and 4905_AT1) or (521_AT1 and 9551_AT2 and 10632_AT1 and 4905_AT1 and 522_AT5 and 516_AT1 and 515_AT1 and 10476_AT1) or (9551_AT1 and 10632_AT1 and 521_AT1 and 515_AT3 and 10476_AT2 and 516_AT1 and 522_AT5 and 4905_AT1) or (516_AT1 and 10476_AT1 and 4905_AT1 and 10632_AT1 and 9551_AT1 and 515_AT2 and 522_AT4 and 521_AT1) or (515_AT3 and 10476_AT1 and 516_AT1 and 522_AT5 and 4905_AT1 and 9551_AT1 and 10632_AT1 and 521_AT1) or (521_AT1 and 522_AT4 and 515_AT2 and 10632_AT1 and 9551_AT2 and 4905_AT1 and 516_AT2 and 10476_AT1) or (4905_AT1 and 522_AT5 and 515_AT3 and 10476_AT1 and 521_AT1 and 517_AT2 and 9551_AT2 and 10632_AT1) or (515_AT2 and 522_AT4 and 521_AT1 and 9551_AT2 and 10632_AT1 and 4905_AT1 and 518_AT3 and 10476_AT1) or (517_AT2 and 521_AT1 and 10632_AT1 and 9551_AT3 and 4905_AT1 and 522_AT5 and 515_AT1 and 10476_AT2) or (515_AT3 and 516_AT1 and 10476_AT1 and 4905_AT1 and 9551_AT2 and 10632_AT1 and 522_AT4 and 521_AT1) or (521_AT1 and 10632_AT1 and 9551_AT1 and 522_AT2 and 4905_AT1 and 515_AT1 and 10476_AT2 and 516_AT1) or (515_AT2 and 521_AT1 and 10632_AT1 and 4905_AT1 and 9551_AT3 and 522_AT2 and 518_AT2 and 10476_AT2) or (521_AT1 and 10632_AT1 and 522_AT2 and 9551_AT3 and 4905_AT1 and 10476_AT1 and 518_AT3 and 515_AT1) or (515_AT3 and 518_AT2 and 10476_AT2 and 4905_AT1 and 522_AT3 and 9551_AT2 and 10632_AT1 and 521_AT1) or (10476_AT2 and 515_AT3 and 522_AT2 and 4905_AT1 and 10632_AT1 and 9551_AT1 and 517_AT2 and 521_AT1) or (515_AT3 and 518_AT3 and 10476_AT1 and 4905_AT1 and 522_AT2 and 9551_AT3 and 10632_AT1 and 521_AT1) or (521_AT1 and 515_AT2 and 522_AT1 and 517_AT2 and 9551_AT2 and 10632_AT1 and 4905_AT1 and 10476_AT2) or (9551_AT3 and 4905_AT1 and 516_AT1 and 10476_AT1 and 515_AT1 and 521_AT1 and 522_AT3 and 10632_AT1) or (10632_AT1 and 9551_AT1 and 517_AT2 and 522_AT4 and 521_AT1 and 10476_AT2 and 515_AT1 and 4905_AT1) or (4905_AT1 and 10476_AT1 and 518_AT2 and 515_AT2 and 521_AT1 and 522_AT3 and 10632_AT1 and 9551_AT1) or (4905_AT1 and 9551_AT3 and 515_AT1 and 10476_AT1 and 521_AT1 and 517_AT1 and 522_AT3 and 10632_AT1) or (4905_AT1 and 10476_AT2 and 516_AT1 and 515_AT3 and 522_AT1 and 521_AT1 and 9551_AT2 and 10632_AT1) or (4905_AT1 and 10476_AT2 and 515_AT2 and 521_AT1 and 518_AT1 and 9551_AT1 and 522_AT3 and 10632_AT1) or (10632_AT1 and 9551_AT1 and 522_AT1 and 521_AT1 and 515_AT1 and 10476_AT1 and 516_AT2 and 4905_AT1) or (522_AT3 and 9551_AT2 and 10632_AT1 and 517_AT1 and 515_AT2 and 521_AT1 and 10476_AT2 and 4905_AT1) or (10476_AT2 and 515_AT3 and 4905_AT1 and 10632_AT1 and 9551_AT1 and 522_AT1 and 518_AT1 and 521_AT1) or (516_AT1 and 10476_AT2 and 515_AT3 and 9551_AT3 and 4905_AT1 and 10632_AT1 and 522_AT1 and 521_AT1) or (4905_AT1 and 522_AT5 and 515_AT3 and 518_AT3 and 10476_AT1 and 521_AT1 and 9551_AT1 and 10632_AT1) or (515_AT1 and 10476_AT1 and 522_AT5 and 4905_AT1 and 9551_AT3 and 10632_AT1 and 521_AT1 and 517_AT2) or (515_AT1 and 10476_AT1 and 518_AT2 and 4905_AT1 and 9551_AT2 and 10632_AT1 and 522_AT4 and 521_AT1) or (9551_AT2 and 522_AT3 and 10632_AT1 and 521_AT1 and 515_AT1 and 10476_AT2 and 518_AT3 and 4905_AT1) or (515_AT1 and 10476_AT1 and 516_AT2 and 4905_AT1 and 9551_AT2 and 10632_AT1 and 522_AT3 and 521_AT1) or (10476_AT2 and 515_AT1 and 516_AT1 and 4905_AT1 and 10632_AT1 and 9551_AT2 and 521_AT1 and 522_AT4) or (9551_AT1 and 10632_AT1 and 521_AT1 and 522_AT4 and 518_AT2 and 10476_AT2 and 515_AT1 and 4905_AT1) or (515_AT1 and 10476_AT1 and 4905_AT1 and 522_AT5 and 9551_AT3 and 10632_AT1 and 521_AT1 and 518_AT1) or (10476_AT1 and 516_AT1 and 4905_AT1 and 9551_AT3 and 10632_AT1 and 521_AT1 and 515_AT2 and 522_AT1) or (4905_AT1 and 522_AT2 and 515_AT1 and 10476_AT2 and 521_AT1 and 518_AT1 and 9551_AT2 and 10632_AT1) or (10476_AT2 and 515_AT1 and 4905_AT1 and 10632_AT1 and 522_AT3 and 9551_AT1 and 518_AT1 and 521_AT1) or (9551_AT2 and 522_AT3 and 10632_AT1 and 517_AT1 and 521_AT1 and 10476_AT1 and 515_AT3 and 4905_AT1) or (515_AT2 and 521_AT1 and 518_AT1 and 522_AT1 and 9551_AT2 and 10632_AT1 and 4905_AT1 and 10476_AT2) or (521_AT1 and 522_AT1 and 518_AT1 and 9551_AT1 and 10632_AT1 and 4905_AT1 and 515_AT1 and 10476_AT2) or (4905_AT1 and 10476_AT1 and 522_AT1 and 517_AT2 and 521_AT1 and 515_AT2 and 10632_AT1 and 9551_AT2) or (10476_AT2 and 515_AT1 and 9551_AT3 and 4905_AT1 and 516_AT2 and 10632_AT1 and 521_AT1 and 522_AT4) or (9551_AT2 and 10632_AT1 and 522_AT1 and 515_AT2 and 521_AT1 and 10476_AT2 and 516_AT2 and 4905_AT1) or (10476_AT1 and 522_AT5 and 4905_AT1 and 516_AT2 and 10632_AT1 and 9551_AT2 and 521_AT1 and 515_AT2) or (9551_AT3 and 522_AT5 and 4905_AT1 and 516_AT2 and 10476_AT1 and 515_AT3 and 521_AT1 and 10632_AT1) or (516_AT1 and 515_AT1 and 10476_AT2 and 4905_AT1 and 10632_AT1 and 9551_AT1 and 522_AT4 and 521_AT1) or (522_AT4 and 521_AT1 and 9551_AT1 and 10632_AT1 and 4905_AT1 and 518_AT2 and 515_AT3 and 10476_AT2) or (522_AT3 and 10632_AT1 and 9551_AT1 and 521_AT1 and 10476_AT1 and 515_AT1 and 516_AT1 and 4905_AT1) or (4905_AT1 and 10476_AT2 and 518_AT2 and 522_AT1 and 515_AT2 and 521_AT1 and 9551_AT2 and 10632_AT1) or (4905_AT1 and 522_AT5 and 10476_AT2 and 515_AT1 and 518_AT1 and 521_AT1 and 10632_AT1 and 9551_AT2) or (9551_AT2 and 10632_AT1 and 521_AT1 and 518_AT2 and 10476_AT1 and 515_AT1 and 522_AT5 and 4905_AT1) or (518_AT3 and 10476_AT2 and 9551_AT3 and 522_AT5 and 4905_AT1 and 10632_AT1 and 515_AT2 and 521_AT1) or (4905_AT1 and 10476_AT1 and 515_AT1 and 518_AT1 and 522_AT1 and 521_AT1 and 9551_AT2 and 10632_AT1) or (522_AT4 and 515_AT2 and 521_AT1 and 10632_AT1 and 9551_AT3 and 4905_AT1 and 518_AT3 and 10476_AT2) or (516_AT1 and 10476_AT2 and 4905_AT1 and 9551_AT2 and 522_AT3 and 10632_AT1 and 515_AT2 and 521_AT1) or (515_AT3 and 10476_AT1 and 518_AT3 and 522_AT5 and 4905_AT1 and 9551_AT2 and 10632_AT1 and 521_AT1) or (4905_AT1 and 522_AT2 and 9551_AT3 and 515_AT1 and 10476_AT1 and 521_AT1 and 518_AT1 and 10632_AT1) or (521_AT1 and 10632_AT1 and 9551_AT3 and 4905_AT1 and 522_AT5 and 10476_AT1 and 516_AT1 and 515_AT3) or (10476_AT1 and 4905_AT1 and 9551_AT2 and 10632_AT1 and 517_AT2 and 515_AT2 and 522_AT4 and 521_AT1) or (515_AT3 and 516_AT1 and 10476_AT2 and 4905_AT1 and 9551_AT3 and 10632_AT1 and 522_AT3 and 521_AT1) or (9551_AT2 and 522_AT3 and 10632_AT1 and 521_AT1 and 517_AT1 and 10476_AT2 and 515_AT1 and 4905_AT1) or (517_AT1 and 521_AT1 and 10632_AT1 and 9551_AT1 and 522_AT2 and 4905_AT1 and 515_AT1 and 10476_AT2) or (10632_AT1 and 521_AT1 and 10476_AT1 and 518_AT3 and 515_AT1 and 522_AT5 and 4905_AT1 and 9551_AT3) or (4905_AT1 and 522_AT5 and 515_AT1 and 10476_AT2 and 518_AT2 and 521_AT1 and 9551_AT2 and 10632_AT1) or (522_AT4 and 515_AT2 and 521_AT1 and 9551_AT2 and 10632_AT1 and 4905_AT1 and 10476_AT2 and 518_AT2) or (9551_AT1 and 10632_AT1 and 521_AT1 and 522_AT4 and 515_AT2 and 518_AT2 and 10476_AT1 and 4905_AT1) or (515_AT2 and 521_AT1 and 10632_AT1 and 9551_AT2 and 516_AT2 and 4905_AT1 and 522_AT2 and 10476_AT1) or (10476_AT2 and 518_AT3 and 515_AT1 and 4905_AT1 and 522_AT5 and 9551_AT2 and 10632_AT1 and 521_AT1) or (9551_AT2 and 10632_AT1 and 517_AT2 and 521_AT1 and 522_AT4 and 10476_AT2 and 515_AT3 and 4905_AT1) or (521_AT1 and 518_AT1 and 9551_AT1 and 10632_AT1 and 522_AT5 and 4905_AT1 and 515_AT3 and 10476_AT1)) and ((509_AT1 and 498_AT3 and 514_AT2 and 513_AT1 and 506_AT1) or (509_AT1 and 498_AT2 and 506_AT1 and 514_AT1 and 513_AT2) or (506_AT1 and 513_AT2 and 509_AT2 and 514_AT2 and 498_AT2) or (509_AT1 and 506_AT1 and 498_AT1 and 513_AT2 and 514_AT1) or (514_AT1 and 513_AT2 and 506_AT1 and 509_AT2 and 498_AT2) or (513_AT1 and 509_AT2 and 514_AT2 and 498_AT2 and 506_AT1) or (509_AT1 and 498_AT3 and 506_AT1 and 513_AT2 and 514_AT1) or (506_AT1 and 513_AT2 and 498_AT3 and 514_AT2 and 509_AT2) or (506_AT1 and 498_AT1 and 513_AT2 and 514_AT1 and 509_AT2) or (514_AT1 and 513_AT2 and 506_AT1 and 509_AT2 and 498_AT3) or (498_AT1 and 506_AT1 and 513_AT2 and 509_AT2 and 514_AT2) or (513_AT2 and 506_AT1 and 514_AT2 and 498_AT3 and 509_AT1) or (509_AT1 and 513_AT1 and 498_AT1 and 506_AT1 and 514_AT1) or (513_AT1 and 514_AT2 and 509_AT1 and 498_AT1 and 506_AT1) or (506_AT1 and 514_AT1 and 509_AT1 and 513_AT1 and 498_AT2) or (498_AT3 and 509_AT2 and 514_AT2 and 513_AT1 and 506_AT1) or (514_AT1 and 506_AT1 and 498_AT1 and 513_AT1 and 509_AT2) or (509_AT1 and 514_AT2 and 498_AT2 and 513_AT1 and 506_AT1) or (509_AT2 and 498_AT2 and 513_AT1 and 506_AT1 and 514_AT1) or (509_AT1 and 498_AT2 and 514_AT2 and 506_AT1 and 513_AT2) or (514_AT1 and 506_AT1 and 509_AT2 and 513_AT1 and 498_AT3) or (513_AT1 and 498_AT3 and 509_AT1 and 514_AT1 and 506_AT1) or (498_AT1 and 506_AT1 and 509_AT2 and 514_AT2 and 513_AT1) or (513_AT2 and 498_AT1 and 506_AT1 and 514_AT2 and 509_AT1))", +"subsystem":"Oxidative Phosphorylation", +"notes":{ +"original_bigg_ids":[ +"ATPS4m" +] +} +}, +{ +"id":"ATPasel", +"name":"V-type ATPase, H+ transporting, lysosomal", +"metabolites":{ +"adp_c":1.0, +"atp_c":-1.0, +"h2o_c":-1.0, +"h_c":-3.0, +"h_l":4.0, +"pi_c":1.0 +}, +"lower_bound":0.0, +"upper_bound":999999.0, +"gene_reaction_rule":"((527_AT1 and 533_AT1 and 9114_AT1 and 535_AT1 and 8992_AT1) or (9114_AT1 and 533_AT1 and 8992_AT1 and 23545_AT1 and 527_AT1) or (527_AT1 and 533_AT1 and 9114_AT1 and 10312_AT2 and 8992_AT1) or (10312_AT2 and 8992_AT1 and 533_AT1 and 245972_AT1 and 527_AT1) or (245972_AT1 and 527_AT1 and 8992_AT1 and 23545_AT1 and 533_AT1) or (50617_AT3 and 527_AT1 and 245972_AT1 and 533_AT1 and 8992_AT1) or (8992_AT1 and 9114_AT1 and 533_AT1 and 50617_AT1 and 527_AT1) or (50617_AT3 and 527_AT1 and 8992_AT1 and 9114_AT1 and 533_AT1) or (50617_AT2 and 8992_AT1 and 9114_AT1 and 533_AT1 and 527_AT1) or (533_AT1 and 8992_AT1 and 245972_AT1 and 527_AT1 and 50617_AT1) or (527_AT1 and 245972_AT1 and 533_AT1 and 50617_AT2 and 8992_AT1) or (533_AT1 and 535_AT1 and 8992_AT1 and 527_AT1 and 245972_AT1) or (527_AT1 and 10312_AT1 and 8992_AT1 and 533_AT1 and 9114_AT1) or (533_AT1 and 8992_AT1 and 527_AT1 and 10312_AT1 and 245972_AT1)) and ((51606_AT2 and 90423_AT1 and 523_AT1 and 9296_AT1 and 526_AT1 and 127124_AT2 and 528_AT2 and 51382_AT1) or (51606_AT1 and 523_AT1 and 526_AT1 and 9296_AT1 and 529_AT1 and 534_AT2 and 528_AT2 and 51382_AT1) or (528_AT2 and 529_AT1 and 9296_AT1 and 51382_AT1 and 525_AT1 and 51606_AT3 and 523_AT1 and 9550_AT1) or (528_AT2 and 9296_AT1 and 526_AT1 and 51382_AT1 and 127124_AT1 and 523_AT1 and 90423_AT1 and 51606_AT1) or (9550_AT1 and 245973_AT1 and 51606_AT3 and 523_AT1 and 525_AT1 and 51382_AT1 and 9296_AT1 and 529_AT1) or (9550_AT1 and 51606_AT1 and 523_AT1 and 525_AT1 and 51382_AT1 and 528_AT1 and 9296_AT1 and 529_AT1) or (51606_AT3 and 523_AT1 and 529_AT1 and 534_AT2 and 526_AT1 and 9296_AT1 and 528_AT1 and 51382_AT1) or (528_AT1 and 51382_AT1 and 529_AT1 and 526_AT1 and 9296_AT1 and 9550_AT1 and 523_AT1 and 51606_AT3) or (523_AT1 and 51606_AT2 and 529_AT1 and 534_AT2 and 9296_AT1 and 526_AT1 and 528_AT1 and 51382_AT1) or (523_AT1 and 51606_AT3 and 127124_AT1 and 90423_AT1 and 9296_AT1 and 51382_AT1 and 528_AT1 and 525_AT1) or (51382_AT1 and 534_AT2 and 529_AT1 and 526_AT1 and 9296_AT1 and 523_AT1 and 245973_AT1 and 51606_AT2) or (9296_AT1 and 529_AT1 and 534_AT2 and 525_AT1 and 51382_AT1 and 528_AT1 and 51606_AT2 and 523_AT1) or (90423_AT1 and 51606_AT1 and 245973_AT1 and 523_AT1 and 51382_AT1 and 526_AT1 and 9296_AT1 and 534_AT2) or (127124_AT1 and 523_AT1 and 51606_AT3 and 51382_AT1 and 9296_AT1 and 526_AT1 and 528_AT2 and 529_AT1) or (523_AT1 and 51606_AT1 and 245973_AT1 and 90423_AT1 and 127124_AT2 and 526_AT1 and 9296_AT1 and 51382_AT1) or (9550_AT1 and 523_AT1 and 51606_AT1 and 245973_AT1 and 51382_AT1 and 525_AT1 and 529_AT1 and 9296_AT1) or (525_AT1 and 51382_AT1 and 528_AT1 and 9296_AT1 and 534_AT2 and 51606_AT1 and 90423_AT1 and 523_AT1) or (51382_AT1 and 529_AT1 and 528_AT2 and 526_AT1 and 127124_AT2 and 9296_AT1 and 51606_AT3 and 523_AT1) or (90423_AT1 and 127124_AT1 and 523_AT1 and 51606_AT3 and 9296_AT1 and 526_AT1 and 51382_AT1 and 528_AT1) or (51382_AT1 and 127124_AT2 and 526_AT1 and 9296_AT1 and 528_AT2 and 90423_AT1 and 523_AT1 and 51606_AT3) or (90423_AT1 and 51606_AT1 and 523_AT1 and 526_AT1 and 9296_AT1 and 534_AT2 and 528_AT2 and 51382_AT1) or (245973_AT1 and 127124_AT1 and 523_AT1 and 51606_AT3 and 51382_AT1 and 9296_AT1 and 526_AT1 and 529_AT1) or (526_AT1 and 9296_AT1 and 51382_AT1 and 90423_AT1 and 245973_AT1 and 523_AT1 and 51606_AT3 and 127124_AT1) or (9296_AT1 and 534_AT2 and 525_AT1 and 51382_AT1 and 90423_AT1 and 245973_AT1 and 51606_AT3 and 523_AT1) or (525_AT1 and 51382_AT1 and 9296_AT1 and 528_AT2 and 51606_AT1 and 534_AT1 and 90423_AT1 and 523_AT1) or (525_AT1 and 528_AT1 and 51382_AT1 and 127124_AT2 and 9296_AT1 and 529_AT1 and 523_AT1 and 51606_AT3) or (51382_AT1 and 526_AT1 and 9296_AT1 and 529_AT1 and 534_AT1 and 245973_AT1 and 51606_AT2 and 523_AT1) or (529_AT1 and 528_AT2 and 526_AT1 and 9296_AT1 and 51382_AT1 and 523_AT1 and 51606_AT1 and 9550_AT1) or (523_AT1 and 51606_AT1 and 90423_AT1 and 9550_AT1 and 9296_AT1 and 528_AT1 and 51382_AT1 and 525_AT1) or (523_AT1 and 245973_AT1 and 51606_AT1 and 51382_AT1 and 529_AT1 and 127124_AT2 and 526_AT1 and 9296_AT1) or (90423_AT1 and 51606_AT1 and 523_AT1 and 9296_AT1 and 526_AT1 and 127124_AT2 and 528_AT2 and 51382_AT1) or (51382_AT1 and 528_AT1 and 526_AT1 and 9296_AT1 and 529_AT1 and 534_AT1 and 523_AT1 and 51606_AT3) or (523_AT1 and 51606_AT2 and 90423_AT1 and 534_AT2 and 9296_AT1 and 528_AT1 and 51382_AT1 and 525_AT1) or (245973_AT1 and 51606_AT2 and 523_AT1 and 9296_AT1 and 529_AT1 and 534_AT2 and 525_AT1 and 51382_AT1) or (523_AT1 and 51606_AT2 and 90423_AT1 and 528_AT2 and 9296_AT1 and 127124_AT2 and 51382_AT1 and 525_AT1) or (523_AT1 and 51606_AT1 and 245973_AT1 and 534_AT1 and 529_AT1 and 9296_AT1 and 51382_AT1 and 525_AT1) or (523_AT1 and 51606_AT2 and 534_AT1 and 90423_AT1 and 9296_AT1 and 51382_AT1 and 528_AT1 and 525_AT1) or (528_AT2 and 526_AT1 and 9296_AT1 and 51382_AT1 and 51606_AT3 and 523_AT1 and 534_AT1 and 90423_AT1) or (523_AT1 and 51606_AT3 and 245973_AT1 and 534_AT1 and 529_AT1 and 9296_AT1 and 526_AT1 and 51382_AT1) or (245973_AT1 and 51606_AT1 and 90423_AT1 and 523_AT1 and 127124_AT1 and 525_AT1 and 51382_AT1 and 9296_AT1) or (523_AT1 and 90423_AT1 and 51606_AT1 and 9296_AT1 and 127124_AT2 and 528_AT1 and 51382_AT1 and 525_AT1) or (523_AT1 and 127124_AT1 and 245973_AT1 and 90423_AT1 and 51606_AT2 and 51382_AT1 and 525_AT1 and 9296_AT1) or (534_AT2 and 9296_AT1 and 526_AT1 and 51382_AT1 and 523_AT1 and 51606_AT2 and 245973_AT1 and 90423_AT1) or (51382_AT1 and 528_AT1 and 526_AT1 and 9296_AT1 and 534_AT1 and 90423_AT1 and 51606_AT3 and 523_AT1) or (528_AT2 and 9296_AT1 and 526_AT1 and 51382_AT1 and 523_AT1 and 534_AT1 and 51606_AT1 and 90423_AT1) or (523_AT1 and 245973_AT1 and 90423_AT1 and 51606_AT2 and 51382_AT1 and 127124_AT2 and 526_AT1 and 9296_AT1) or (90423_AT1 and 51606_AT3 and 523_AT1 and 9550_AT1 and 526_AT1 and 9296_AT1 and 51382_AT1 and 528_AT1) or (529_AT1 and 9296_AT1 and 526_AT1 and 127124_AT2 and 51382_AT1 and 523_AT1 and 51606_AT3 and 245973_AT1) or (529_AT1 and 528_AT2 and 9296_AT1 and 51382_AT1 and 525_AT1 and 51606_AT3 and 523_AT1 and 534_AT1) or (127124_AT1 and 523_AT1 and 51606_AT1 and 529_AT1 and 9296_AT1 and 528_AT1 and 51382_AT1 and 525_AT1) or (523_AT1 and 51606_AT3 and 9550_AT1 and 528_AT2 and 529_AT1 and 9296_AT1 and 526_AT1 and 51382_AT1) or (51382_AT1 and 528_AT1 and 526_AT1 and 9296_AT1 and 534_AT2 and 90423_AT1 and 51606_AT3 and 523_AT1) or (529_AT1 and 528_AT2 and 526_AT1 and 9296_AT1 and 51382_AT1 and 523_AT1 and 534_AT1 and 51606_AT2) or (529_AT1 and 9296_AT1 and 526_AT1 and 528_AT1 and 51382_AT1 and 523_AT1 and 51606_AT2 and 9550_AT1) or (9296_AT1 and 526_AT1 and 127124_AT2 and 529_AT1 and 51382_AT1 and 528_AT1 and 51606_AT2 and 523_AT1) or (523_AT1 and 51606_AT1 and 51382_AT1 and 528_AT1 and 529_AT1 and 127124_AT2 and 526_AT1 and 9296_AT1) or (523_AT1 and 51606_AT3 and 525_AT1 and 51382_AT1 and 9296_AT1 and 534_AT2 and 529_AT1 and 528_AT2) or (523_AT1 and 245973_AT1 and 51606_AT2 and 51382_AT1 and 529_AT1 and 526_AT1 and 127124_AT2 and 9296_AT1) or (9296_AT1 and 528_AT2 and 525_AT1 and 51382_AT1 and 51606_AT1 and 90423_AT1 and 523_AT1 and 9550_AT1) or (528_AT2 and 534_AT2 and 9296_AT1 and 526_AT1 and 51382_AT1 and 51606_AT3 and 523_AT1 and 90423_AT1) or (51382_AT1 and 528_AT2 and 526_AT1 and 9296_AT1 and 9550_AT1 and 523_AT1 and 51606_AT3 and 90423_AT1) or (90423_AT1 and 127124_AT1 and 51606_AT3 and 523_AT1 and 9296_AT1 and 528_AT2 and 525_AT1 and 51382_AT1) or (534_AT1 and 90423_AT1 and 245973_AT1 and 51606_AT1 and 523_AT1 and 525_AT1 and 51382_AT1 and 9296_AT1) or (9296_AT1 and 534_AT2 and 529_AT1 and 528_AT2 and 525_AT1 and 51382_AT1 and 51606_AT2 and 523_AT1) or (127124_AT1 and 523_AT1 and 51606_AT3 and 529_AT1 and 9296_AT1 and 528_AT1 and 51382_AT1 and 525_AT1) or (528_AT1 and 51382_AT1 and 526_AT1 and 9296_AT1 and 90423_AT1 and 534_AT1 and 51606_AT2 and 523_AT1) or (51382_AT1 and 528_AT1 and 9296_AT1 and 526_AT1 and 51606_AT2 and 90423_AT1 and 127124_AT1 and 523_AT1) or (9296_AT1 and 526_AT1 and 528_AT2 and 529_AT1 and 51382_AT1 and 534_AT1 and 51606_AT1 and 523_AT1) or (9296_AT1 and 528_AT1 and 51382_AT1 and 525_AT1 and 523_AT1 and 127124_AT1 and 51606_AT1 and 90423_AT1) or (51606_AT1 and 245973_AT1 and 523_AT1 and 525_AT1 and 51382_AT1 and 9296_AT1 and 127124_AT2 and 529_AT1) or (526_AT1 and 9296_AT1 and 529_AT1 and 51382_AT1 and 245973_AT1 and 51606_AT3 and 523_AT1 and 9550_AT1) or (51382_AT1 and 9296_AT1 and 526_AT1 and 529_AT1 and 9550_AT1 and 51606_AT2 and 245973_AT1 and 523_AT1) or (51382_AT1 and 525_AT1 and 528_AT2 and 529_AT1 and 9296_AT1 and 127124_AT1 and 51606_AT3 and 523_AT1) or (51382_AT1 and 528_AT1 and 525_AT1 and 127124_AT2 and 9296_AT1 and 523_AT1 and 51606_AT3 and 90423_AT1) or (523_AT1 and 245973_AT1 and 51606_AT1 and 9550_AT1 and 529_AT1 and 9296_AT1 and 526_AT1 and 51382_AT1) or (9296_AT1 and 525_AT1 and 528_AT1 and 51382_AT1 and 90423_AT1 and 51606_AT2 and 523_AT1 and 9550_AT1) or (525_AT1 and 51382_AT1 and 9296_AT1 and 528_AT2 and 534_AT2 and 90423_AT1 and 523_AT1 and 51606_AT3) or (51382_AT1 and 526_AT1 and 9296_AT1 and 528_AT2 and 90423_AT1 and 51606_AT3 and 523_AT1 and 127124_AT1) or (523_AT1 and 127124_AT1 and 51606_AT2 and 51382_AT1 and 529_AT1 and 528_AT2 and 526_AT1 and 9296_AT1) or (523_AT1 and 51606_AT1 and 245973_AT1 and 534_AT2 and 529_AT1 and 9296_AT1 and 51382_AT1 and 525_AT1) or (51382_AT1 and 525_AT1 and 9296_AT1 and 127124_AT2 and 523_AT1 and 51606_AT1 and 245973_AT1 and 90423_AT1) or (9550_AT1 and 51606_AT1 and 523_AT1 and 51382_AT1 and 528_AT1 and 9296_AT1 and 526_AT1 and 529_AT1) or (9550_AT1 and 51606_AT2 and 523_AT1 and 525_AT1 and 51382_AT1 and 9296_AT1 and 529_AT1 and 528_AT2) or (51382_AT1 and 528_AT2 and 9296_AT1 and 526_AT1 and 127124_AT1 and 523_AT1 and 51606_AT2 and 90423_AT1) or (127124_AT2 and 9296_AT1 and 529_AT1 and 528_AT2 and 525_AT1 and 51382_AT1 and 51606_AT1 and 523_AT1) or (51606_AT1 and 523_AT1 and 9296_AT1 and 526_AT1 and 534_AT2 and 529_AT1 and 528_AT1 and 51382_AT1) or (529_AT1 and 9296_AT1 and 51382_AT1 and 525_AT1 and 127124_AT1 and 523_AT1 and 245973_AT1 and 51606_AT1) or (528_AT1 and 51382_AT1 and 525_AT1 and 9296_AT1 and 523_AT1 and 90423_AT1 and 534_AT1 and 51606_AT1) or (529_AT1 and 9296_AT1 and 51382_AT1 and 525_AT1 and 523_AT1 and 51606_AT2 and 534_AT1 and 245973_AT1) or (245973_AT1 and 51606_AT2 and 523_AT1 and 127124_AT1 and 9296_AT1 and 529_AT1 and 525_AT1 and 51382_AT1) or (9296_AT1 and 529_AT1 and 525_AT1 and 528_AT1 and 51382_AT1 and 51606_AT1 and 534_AT1 and 523_AT1) or (90423_AT1 and 523_AT1 and 51606_AT3 and 525_AT1 and 51382_AT1 and 127124_AT2 and 9296_AT1 and 528_AT2) or (9296_AT1 and 529_AT1 and 525_AT1 and 51382_AT1 and 528_AT1 and 51606_AT3 and 523_AT1 and 9550_AT1) or (525_AT1 and 51382_AT1 and 9296_AT1 and 528_AT2 and 529_AT1 and 51606_AT1 and 127124_AT1 and 523_AT1) or (529_AT1 and 526_AT1 and 9296_AT1 and 51382_AT1 and 528_AT1 and 523_AT1 and 534_AT1 and 51606_AT2) or (523_AT1 and 51606_AT1 and 534_AT1 and 528_AT1 and 51382_AT1 and 529_AT1 and 526_AT1 and 9296_AT1) or (528_AT2 and 526_AT1 and 9296_AT1 and 51382_AT1 and 523_AT1 and 51606_AT1 and 90423_AT1 and 9550_AT1) or (51606_AT1 and 523_AT1 and 51382_AT1 and 9296_AT1 and 127124_AT2 and 526_AT1 and 528_AT2 and 529_AT1) or (51382_AT1 and 529_AT1 and 9296_AT1 and 526_AT1 and 523_AT1 and 534_AT1 and 51606_AT1 and 245973_AT1) or (51606_AT1 and 523_AT1 and 127124_AT1 and 51382_AT1 and 526_AT1 and 9296_AT1 and 529_AT1 and 528_AT2) or (523_AT1 and 51606_AT3 and 245973_AT1 and 90423_AT1 and 9296_AT1 and 526_AT1 and 127124_AT2 and 51382_AT1) or (51606_AT3 and 523_AT1 and 245973_AT1 and 534_AT2 and 529_AT1 and 9296_AT1 and 51382_AT1 and 525_AT1) or (9550_AT1 and 90423_AT1 and 51606_AT2 and 523_AT1 and 525_AT1 and 51382_AT1 and 9296_AT1 and 528_AT2) or (51606_AT3 and 523_AT1 and 127124_AT1 and 90423_AT1 and 245973_AT1 and 9296_AT1 and 51382_AT1 and 525_AT1) or (525_AT1 and 51382_AT1 and 9296_AT1 and 534_AT2 and 245973_AT1 and 51606_AT1 and 90423_AT1 and 523_AT1) or (51606_AT2 and 523_AT1 and 127124_AT1 and 525_AT1 and 528_AT1 and 51382_AT1 and 9296_AT1 and 529_AT1) or (51606_AT2 and 245973_AT1 and 523_AT1 and 9296_AT1 and 127124_AT2 and 529_AT1 and 525_AT1 and 51382_AT1) or (51382_AT1 and 9296_AT1 and 526_AT1 and 90423_AT1 and 51606_AT1 and 245973_AT1 and 127124_AT1 and 523_AT1) or (529_AT1 and 9296_AT1 and 127124_AT2 and 528_AT1 and 51382_AT1 and 525_AT1 and 523_AT1 and 51606_AT1) or (51382_AT1 and 529_AT1 and 528_AT2 and 526_AT1 and 9296_AT1 and 523_AT1 and 51606_AT3 and 534_AT1) or (523_AT1 and 90423_AT1 and 51606_AT1 and 534_AT2 and 528_AT2 and 9296_AT1 and 51382_AT1 and 525_AT1) or (127124_AT2 and 9296_AT1 and 528_AT2 and 525_AT1 and 51382_AT1 and 51606_AT1 and 90423_AT1 and 523_AT1) or (523_AT1 and 51606_AT2 and 9550_AT1 and 529_AT1 and 528_AT2 and 526_AT1 and 9296_AT1 and 51382_AT1) or (90423_AT1 and 245973_AT1 and 523_AT1 and 51606_AT3 and 127124_AT2 and 9296_AT1 and 525_AT1 and 51382_AT1) or (523_AT1 and 51606_AT3 and 245973_AT1 and 51382_AT1 and 534_AT2 and 529_AT1 and 9296_AT1 and 526_AT1) or (523_AT1 and 534_AT1 and 90423_AT1 and 245973_AT1 and 51606_AT2 and 51382_AT1 and 526_AT1 and 9296_AT1) or (523_AT1 and 51606_AT2 and 534_AT1 and 529_AT1 and 9296_AT1 and 51382_AT1 and 528_AT1 and 525_AT1) or (523_AT1 and 127124_AT1 and 245973_AT1 and 51606_AT1 and 529_AT1 and 526_AT1 and 9296_AT1 and 51382_AT1) or (534_AT2 and 526_AT1 and 9296_AT1 and 528_AT1 and 51382_AT1 and 523_AT1 and 90423_AT1 and 51606_AT2) or (9550_AT1 and 523_AT1 and 51606_AT1 and 51382_AT1 and 525_AT1 and 529_AT1 and 528_AT2 and 9296_AT1) or (9296_AT1 and 528_AT2 and 529_AT1 and 534_AT2 and 525_AT1 and 51382_AT1 and 51606_AT1 and 523_AT1) or (523_AT1 and 127124_AT1 and 90423_AT1 and 51606_AT1 and 526_AT1 and 9296_AT1 and 51382_AT1 and 528_AT1) or (526_AT1 and 9296_AT1 and 528_AT1 and 51382_AT1 and 90423_AT1 and 51606_AT1 and 523_AT1 and 9550_AT1) or (523_AT1 and 534_AT1 and 51606_AT2 and 529_AT1 and 528_AT2 and 9296_AT1 and 51382_AT1 and 525_AT1) or (9550_AT1 and 523_AT1 and 51606_AT2 and 245973_AT1 and 90423_AT1 and 51382_AT1 and 9296_AT1 and 526_AT1) or (528_AT1 and 51382_AT1 and 525_AT1 and 9296_AT1 and 127124_AT2 and 523_AT1 and 51606_AT2 and 90423_AT1) or (525_AT1 and 51382_AT1 and 9296_AT1 and 529_AT1 and 245973_AT1 and 127124_AT1 and 51606_AT3 and 523_AT1) or (127124_AT1 and 523_AT1 and 51606_AT2 and 90423_AT1 and 528_AT1 and 51382_AT1 and 525_AT1 and 9296_AT1) or (51382_AT1 and 528_AT1 and 127124_AT2 and 526_AT1 and 9296_AT1 and 90423_AT1 and 51606_AT2 and 523_AT1) or (127124_AT2 and 526_AT1 and 9296_AT1 and 51382_AT1 and 528_AT1 and 523_AT1 and 51606_AT1 and 90423_AT1) or (51382_AT1 and 525_AT1 and 529_AT1 and 528_AT2 and 9296_AT1 and 523_AT1 and 127124_AT1 and 51606_AT2) or (529_AT1 and 9296_AT1 and 51382_AT1 and 525_AT1 and 51606_AT3 and 523_AT1 and 245973_AT1 and 534_AT1) or (51606_AT3 and 523_AT1 and 51382_AT1 and 9296_AT1 and 526_AT1 and 528_AT2 and 534_AT2 and 529_AT1) or (9296_AT1 and 526_AT1 and 51382_AT1 and 127124_AT1 and 523_AT1 and 51606_AT2 and 90423_AT1 and 245973_AT1) or (523_AT1 and 51606_AT2 and 90423_AT1 and 9550_AT1 and 9296_AT1 and 526_AT1 and 51382_AT1 and 528_AT1) or (9296_AT1 and 526_AT1 and 528_AT2 and 534_AT2 and 51382_AT1 and 51606_AT2 and 90423_AT1 and 523_AT1) or (9550_AT1 and 523_AT1 and 51606_AT3 and 245973_AT1 and 90423_AT1 and 51382_AT1 and 9296_AT1 and 526_AT1) or (9296_AT1 and 525_AT1 and 51382_AT1 and 245973_AT1 and 90423_AT1 and 51606_AT2 and 523_AT1 and 9550_AT1) or (534_AT2 and 9296_AT1 and 51382_AT1 and 525_AT1 and 523_AT1 and 51606_AT2 and 90423_AT1 and 245973_AT1) or (534_AT2 and 529_AT1 and 526_AT1 and 9296_AT1 and 51382_AT1 and 523_AT1 and 245973_AT1 and 51606_AT1) or (525_AT1 and 51382_AT1 and 9296_AT1 and 9550_AT1 and 90423_AT1 and 245973_AT1 and 523_AT1 and 51606_AT3) or (51606_AT2 and 90423_AT1 and 127124_AT1 and 523_AT1 and 525_AT1 and 51382_AT1 and 9296_AT1 and 528_AT2) or (9550_AT1 and 245973_AT1 and 51606_AT2 and 523_AT1 and 525_AT1 and 51382_AT1 and 9296_AT1 and 529_AT1) or (523_AT1 and 245973_AT1 and 90423_AT1 and 534_AT1 and 51606_AT2 and 51382_AT1 and 525_AT1 and 9296_AT1) or (9296_AT1 and 528_AT2 and 525_AT1 and 51382_AT1 and 90423_AT1 and 523_AT1 and 51606_AT3 and 9550_AT1) or (51606_AT2 and 523_AT1 and 526_AT1 and 127124_AT2 and 9296_AT1 and 529_AT1 and 528_AT2 and 51382_AT1) or (526_AT1 and 9296_AT1 and 51382_AT1 and 245973_AT1 and 534_AT1 and 90423_AT1 and 523_AT1 and 51606_AT3) or (51382_AT1 and 525_AT1 and 528_AT2 and 9296_AT1 and 51606_AT3 and 523_AT1 and 90423_AT1 and 534_AT1) or (9296_AT1 and 51382_AT1 and 525_AT1 and 523_AT1 and 245973_AT1 and 51606_AT1 and 90423_AT1 and 9550_AT1) or (523_AT1 and 534_AT1 and 90423_AT1 and 51606_AT2 and 51382_AT1 and 525_AT1 and 528_AT2 and 9296_AT1) or (51382_AT1 and 528_AT1 and 127124_AT2 and 526_AT1 and 9296_AT1 and 90423_AT1 and 523_AT1 and 51606_AT3) or (523_AT1 and 51606_AT2 and 534_AT1 and 90423_AT1 and 528_AT2 and 9296_AT1 and 526_AT1 and 51382_AT1) or (529_AT1 and 9296_AT1 and 526_AT1 and 51382_AT1 and 528_AT1 and 127124_AT1 and 523_AT1 and 51606_AT1) or (51606_AT2 and 127124_AT1 and 523_AT1 and 51382_AT1 and 528_AT1 and 9296_AT1 and 526_AT1 and 529_AT1) or (525_AT1 and 528_AT1 and 51382_AT1 and 9296_AT1 and 127124_AT2 and 529_AT1 and 51606_AT2 and 523_AT1) or (90423_AT1 and 245973_AT1 and 51606_AT3 and 523_AT1 and 51382_AT1 and 526_AT1 and 9296_AT1 and 534_AT2) or (51382_AT1 and 528_AT1 and 9296_AT1 and 526_AT1 and 523_AT1 and 51606_AT1 and 534_AT1 and 90423_AT1) or (51382_AT1 and 528_AT1 and 525_AT1 and 9296_AT1 and 9550_AT1 and 523_AT1 and 51606_AT3 and 90423_AT1) or (523_AT1 and 51606_AT1 and 534_AT1 and 528_AT2 and 529_AT1 and 9296_AT1 and 51382_AT1 and 525_AT1) or (528_AT1 and 51382_AT1 and 526_AT1 and 127124_AT2 and 9296_AT1 and 529_AT1 and 523_AT1 and 51606_AT3) or (90423_AT1 and 51606_AT1 and 523_AT1 and 528_AT1 and 51382_AT1 and 526_AT1 and 9296_AT1 and 534_AT2) or (51382_AT1 and 528_AT2 and 526_AT1 and 9296_AT1 and 9550_AT1 and 523_AT1 and 90423_AT1 and 51606_AT2) or (127124_AT1 and 523_AT1 and 51606_AT2 and 245973_AT1 and 51382_AT1 and 529_AT1 and 9296_AT1 and 526_AT1) or (525_AT1 and 51382_AT1 and 9296_AT1 and 528_AT2 and 534_AT2 and 51606_AT2 and 90423_AT1 and 523_AT1) or (51606_AT3 and 523_AT1 and 525_AT1 and 51382_AT1 and 127124_AT2 and 9296_AT1 and 529_AT1 and 528_AT2) or (51382_AT1 and 525_AT1 and 9296_AT1 and 523_AT1 and 51606_AT3 and 90423_AT1 and 245973_AT1 and 534_AT1) or (9296_AT1 and 526_AT1 and 51382_AT1 and 523_AT1 and 534_AT1 and 51606_AT1 and 90423_AT1 and 245973_AT1) or (51606_AT1 and 523_AT1 and 525_AT1 and 528_AT1 and 51382_AT1 and 9296_AT1 and 529_AT1 and 534_AT2) or (127124_AT2 and 9296_AT1 and 51382_AT1 and 525_AT1 and 523_AT1 and 245973_AT1 and 90423_AT1 and 51606_AT2) or (51606_AT3 and 523_AT1 and 534_AT1 and 90423_AT1 and 51382_AT1 and 528_AT1 and 525_AT1 and 9296_AT1) or (51606_AT2 and 523_AT1 and 9550_AT1 and 9296_AT1 and 529_AT1 and 525_AT1 and 51382_AT1 and 528_AT1) or (90423_AT1 and 51606_AT3 and 523_AT1 and 525_AT1 and 51382_AT1 and 528_AT1 and 9296_AT1 and 534_AT2) or (523_AT1 and 51606_AT3 and 245973_AT1 and 51382_AT1 and 525_AT1 and 529_AT1 and 9296_AT1 and 127124_AT2) or (51382_AT1 and 525_AT1 and 528_AT2 and 529_AT1 and 9296_AT1 and 127124_AT2 and 523_AT1 and 51606_AT2) or (90423_AT1 and 51606_AT1 and 127124_AT1 and 523_AT1 and 525_AT1 and 51382_AT1 and 9296_AT1 and 528_AT2) or (526_AT1 and 9296_AT1 and 51382_AT1 and 523_AT1 and 245973_AT1 and 51606_AT1 and 90423_AT1 and 9550_AT1) or (523_AT1 and 51606_AT3 and 534_AT1 and 529_AT1 and 9296_AT1 and 51382_AT1 and 528_AT1 and 525_AT1) or (525_AT1 and 51382_AT1 and 528_AT1 and 9296_AT1 and 534_AT2 and 529_AT1 and 51606_AT3 and 523_AT1) or (51606_AT2 and 523_AT1 and 51382_AT1 and 9296_AT1 and 526_AT1 and 528_AT2 and 529_AT1 and 534_AT2) or (9296_AT1 and 526_AT1 and 529_AT1 and 528_AT1 and 51382_AT1 and 127124_AT1 and 523_AT1 and 51606_AT3))", +"subsystem":"Transport, Lysosomal", +"notes":{ +"original_bigg_ids":[ +"ATPasel" +] +} +}, +{ +"id":"ATPtm", +"name":"ADP/ATP transporter, mitochondrial", +"metabolites":{ +"adp_c":-1.0, +"adp_m":1.0, +"atp_c":1.0, +"atp_m":-1.0 +}, +"lower_bound":0.0, +"upper_bound":999999.0, +"gene_reaction_rule":"293_AT1 or 292_AT1 or 291_AT1", +"subsystem":"Transport, Mitochondrial", +"notes":{ +"original_bigg_ids":[ +"ATPtm" +] +} +}, +{ +"id":"ATPtn", +"name":"ATP diffusion in nucleus", +"metabolites":{ +"atp_c":-1.0, +"atp_n":1.0 +}, +"lower_bound":-999999.0, +"upper_bound":999999.0, +"gene_reaction_rule":"", +"subsystem":"Transport, Nuclear", +"notes":{ +"original_bigg_ids":[ +"ATPtn" +] +} +}, +{ +"id":"ATPtx", +"name":"ATP transporter, peroxisomal", +"metabolites":{ +"atp_c":-1.0, +"atp_x":1.0 +}, +"lower_bound":-999999.0, +"upper_bound":999999.0, +"gene_reaction_rule":"", +"subsystem":"Transport, Peroxisomal", +"notes":{ +"original_bigg_ids":[ +"ATPtx" +] +} +}, +{ +"id":"AVITE1t", +"name":"Alpha-Tocopherol (Vit. E) transport", +"metabolites":{ +"avite1_c":1.0, +"avite1_e":-1.0 +}, +"lower_bound":0.0, +"upper_bound":999999.0, +"gene_reaction_rule":"", +"subsystem":"Transport, Extracellular", +"notes":{ +"original_bigg_ids":[ +"AVITE1t" +] +} +}, +{ +"id":"AVITE2t", +"name":"Alpha-tocotrienol (Vit. E) transport", +"metabolites":{ +"avite2_c":1.0, +"avite2_e":-1.0 +}, +"lower_bound":0.0, +"upper_bound":999999.0, +"gene_reaction_rule":"", +"subsystem":"Transport, Extracellular", +"notes":{ +"original_bigg_ids":[ +"AVITE2t" +] +} +}, +{ +"id":"A_MANASE", +"name":"Alpha-mannosidase", +"metabolites":{ +"h2o_c":-2.0, +"m2mn_c":-1.0, +"man_c":2.0, +"mn_c":1.0 +}, +"lower_bound":0.0, +"upper_bound":999999.0, +"gene_reaction_rule":"4123_AT1", +"subsystem":"N-Glycan Degradation", +"notes":{ +"original_bigg_ids":[ +"A_MANASE" +] +} +}, +{ +"id":"A_MANASEly", +"name":"Alpha-mannosidase, lysosomal", +"metabolites":{ +"h2o_l":-2.0, +"m2mn_l":-1.0, +"man_l":2.0, +"mn_l":1.0 +}, +"lower_bound":0.0, +"upper_bound":999999.0, +"gene_reaction_rule":"4125_AT1", +"subsystem":"N-Glycan Degradation", +"notes":{ +"original_bigg_ids":[ +"A_MANASEly" +] +} +}, +{ +"id":"B3GALT3g", +"name":"Beta-1,3-galactosyltransferase 3", +"metabolites":{ +"gbside_hs_g":1.0, +"h_g":1.0, +"thcrm_hs_g":-1.0, +"udp_g":1.0, +"udpacgal_g":-1.0 +}, +"lower_bound":0.0, +"upper_bound":999999.0, +"gene_reaction_rule":"8706_AT2 or 8706_AT1 or 8706_AT3 or 8706_AT4", +"subsystem":"Sphingolipid Metabolism", +"notes":{ +"original_bigg_ids":[ +"B3GALT3g" +] +} +}, +{ +"id":"B3GALT41g", +"name":"Beta-1,3-galactosyltransferase 4", +"metabolites":{ +"ga1_hs_g":1.0, +"ga2_hs_g":-1.0, +"h_g":1.0, +"udp_g":1.0, +"udpgal_g":-1.0 +}, +"lower_bound":0.0, +"upper_bound":999999.0, +"gene_reaction_rule":"8705_AT1", +"subsystem":"Sphingolipid Metabolism", +"notes":{ +"original_bigg_ids":[ +"B3GALT41g" +] +} +}, +{ +"id":"B3GALT42g", +"name":"Beta-1,3-galactosyltransferase 4", +"metabolites":{ +"gm1_hs_g":1.0, +"gm2_hs_g":-1.0, +"h_g":1.0, +"udp_g":1.0, +"udpgal_g":-1.0 +}, +"lower_bound":0.0, +"upper_bound":999999.0, +"gene_reaction_rule":"8705_AT1", +"subsystem":"Sphingolipid Metabolism", +"notes":{ +"original_bigg_ids":[ +"B3GALT42g" +] +} +}, +{ +"id":"B3GALT43g", +"name":"Beta-1,3-galactosyltransferase 4", +"metabolites":{ +"gd1b_hs_g":1.0, +"gd2_hs_g":-1.0, +"h_g":1.0, +"udp_g":1.0, +"udpgal_g":-1.0 +}, +"lower_bound":0.0, +"upper_bound":999999.0, +"gene_reaction_rule":"8705_AT1", +"subsystem":"Sphingolipid Metabolism", +"notes":{ +"original_bigg_ids":[ +"B3GALT43g" +] +} +}, +{ +"id":"B3GALT44g", +"name":"Beta-1,3-galactosyltransferase 4", +"metabolites":{ +"gt1c_hs_g":1.0, +"gt2_hs_g":-1.0, +"h_g":1.0, +"udp_g":1.0, +"udpgal_g":-1.0 +}, +"lower_bound":0.0, +"upper_bound":999999.0, +"gene_reaction_rule":"8705_AT1", +"subsystem":"Sphingolipid Metabolism", +"notes":{ +"original_bigg_ids":[ +"B3GALT44g" +] +} +}, +{ +"id":"B3GALT5g", +"name":"Beta-1,3-galactosyltransferase 5", +"metabolites":{ +"galgbside_hs_g":1.0, +"gbside_hs_g":-1.0, +"h_g":1.0, +"udp_g":1.0, +"udpgal_g":-1.0 +}, +"lower_bound":0.0, +"upper_bound":999999.0, +"gene_reaction_rule":"10317_AT4 or 10317_AT5 or 10317_AT3 or 10317_AT1 or 10317_AT2", +"subsystem":"Sphingolipid Metabolism", +"notes":{ +"original_bigg_ids":[ +"B3GALT5g" +] +} +}, +{ +"id":"B3GALTg", +"name":"Beta galactosyltransferase", +"metabolites":{ +"acglcgalgluside_hs_g":-1.0, +"galacglcgalgluside_hs_g":1.0, +"h_g":1.0, +"udp_g":1.0, +"udpgal_g":-1.0 +}, +"lower_bound":0.0, +"upper_bound":999999.0, +"gene_reaction_rule":"", +"subsystem":"Blood Group Biosynthesis", +"notes":{ +"original_bigg_ids":[ +"B3GALTg" +] +} +}, +{ +"id":"B3GNT11g", +"name":"UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1", +"metabolites":{ +"acglcgal14acglcgalgluside_hs_g":1.0, +"gal14acglcgalgluside_hs_g":-1.0, +"h_g":1.0, +"uacgam_g":-1.0, +"udp_g":1.0 +}, +"lower_bound":0.0, +"upper_bound":999999.0, +"gene_reaction_rule":"10678_AT1", +"subsystem":"Blood Group Biosynthesis", +"notes":{ +"original_bigg_ids":[ +"B3GNT11g" +] +} +}, +{ +"id":"B3GNT12g", +"name":"UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1", +"metabolites":{ +"acglc13galacglcgal14acglcgalgluside_hs_g":1.0, +"galacglcgal14acglcgalgluside_hs_g":-1.0, +"h_g":1.0, +"uacgam_g":-1.0, +"udp_g":1.0 +}, +"lower_bound":0.0, +"upper_bound":999999.0, +"gene_reaction_rule":"10678_AT1 or 10678_AT2", +"subsystem":"Blood Group Biosynthesis", +"notes":{ +"original_bigg_ids":[ +"B3GNT12g" +] +} +}, +{ +"id":"B3GNT310g", +"name":"UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus", +"metabolites":{ +"acglcgalgluside_hs_g":-1.0, +"gal14acglcgalgluside_hs_g":1.0, +"h_g":1.0, +"udp_g":1.0, +"udpgal_g":-1.0 +}, +"lower_bound":0.0, +"upper_bound":999999.0, +"gene_reaction_rule":"10331_AT1", +"subsystem":"Blood Group Biosynthesis", +"notes":{ +"original_bigg_ids":[ +"B3GNT310g" +] +} +}, +{ +"id":"B3GNT311g", +"name":"UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus", +"metabolites":{ +"acgalfuc12gal14acglcgalgluside_hs_g":-1.0, +"galacgalfuc12gal14acglcgalgluside_hs_g":1.0, +"h_g":1.0, +"udp_g":1.0, +"udpgal_g":-1.0 +}, +"lower_bound":0.0, +"upper_bound":999999.0, +"gene_reaction_rule":"10331_AT1", +"subsystem":"Blood Group Biosynthesis", +"notes":{ +"original_bigg_ids":[ +"B3GNT311g" +] +} +}, +{ +"id":"B3GNT312g", +"name":"UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus", +"metabolites":{ +"acglcgal14acglcgalgluside_hs_g":-1.0, +"galacglcgal14acglcgalgluside_hs_g":1.0, +"h_g":1.0, +"udp_g":1.0, +"udpgal_g":-1.0 +}, +"lower_bound":0.0, +"upper_bound":999999.0, +"gene_reaction_rule":"10331_AT1", +"subsystem":"Blood Group Biosynthesis", +"notes":{ +"original_bigg_ids":[ +"B3GNT312g" +] +} +}, +{ +"id":"B3GNT313g", +"name":"UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus", +"metabolites":{ +"acgalfucgalacglcgal14acglcgalgluside_hs_g":-1.0, +"galacgalfucgalacglcgal14acglcgalgluside_hs_g":1.0, +"h_g":1.0, +"udp_g":1.0, +"udpgal_g":-1.0 +}, +"lower_bound":0.0, +"upper_bound":999999.0, +"gene_reaction_rule":"10331_AT1", +"subsystem":"Blood Group Biosynthesis", +"notes":{ +"original_bigg_ids":[ +"B3GNT313g" +] +} +}, +{ +"id":"B3GNT314g", +"name":"UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus", +"metabolites":{ +"acglcgalacglcgal14acglcgalgluside_hs_g":-1.0, +"galacglcgalacglcgal14acglcgalgluside_hs_g":1.0, +"h_g":1.0, +"udp_g":1.0, +"udpgal_g":-1.0 +}, +"lower_bound":0.0, +"upper_bound":999999.0, +"gene_reaction_rule":"10331_AT1", +"subsystem":"Blood Group Biosynthesis", +"notes":{ +"original_bigg_ids":[ +"B3GNT314g" +] +} +}, +{ +"id":"B3GNT315g", +"name":"UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus", +"metabolites":{ +"acglc13galacglcgal14acglcgalgluside_hs_g":-1.0, +"galacglc13galacglcgal14acglcgalgluside_hs_g":1.0, +"h_g":1.0, +"udp_g":1.0, +"udpgal_g":-1.0 +}, +"lower_bound":0.0, +"upper_bound":999999.0, +"gene_reaction_rule":"10331_AT1", +"subsystem":"Blood Group Biosynthesis", +"notes":{ +"original_bigg_ids":[ +"B3GNT315g" +] +} +}, +{ +"id":"B3GNT31g", +"name":"UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus", +"metabolites":{ +"galthcrm_hs_g":1.0, +"h_g":1.0, +"thcrm_hs_g":-1.0, +"udp_g":1.0, +"udpgal_g":-1.0 +}, +"lower_bound":0.0, +"upper_bound":999999.0, +"gene_reaction_rule":"10331_AT1", +"subsystem":"Sphingolipid Metabolism", +"notes":{ +"original_bigg_ids":[ +"B3GNT31g" +] +} +}, +{ +"id":"B3GNT32g", +"name":"UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus", +"metabolites":{ +"galgalthcrm_hs_g":1.0, +"galthcrm_hs_g":-1.0, +"h_g":1.0, +"udp_g":1.0, +"udpgal_g":-1.0 +}, +"lower_bound":0.0, +"upper_bound":999999.0, +"gene_reaction_rule":"10331_AT1", +"subsystem":"Sphingolipid Metabolism", +"notes":{ +"original_bigg_ids":[ +"B3GNT32g" +] +} +}, +{ +"id":"B3GNT33g", +"name":"UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus", +"metabolites":{ +"galgalgalthcrm_hs_g":1.0, +"galgalthcrm_hs_g":-1.0, +"h_g":1.0, +"udp_g":1.0, +"udpgal_g":-1.0 +}, +"lower_bound":0.0, +"upper_bound":999999.0, +"gene_reaction_rule":"10331_AT1", 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4697_AT1 and 4695_AT1 and 55967_AT1 and 4729_AT1) or (4728_AT1 and 4708_AT1 and 4720_AT1 and 55967_AT1 and 4695_AT1 and 4729_AT1 and 4709_AT1 and 4697_AT1 and 51079_AT1 and 7991_AT1 and 374291_AT1 and 4536_AT1 and 4722_AT1 and 4731_AT2 and 4537_AT1 and 4705_AT1 and 4704_AT1 and 4707_AT1 and 4694_AT1 and 4718_AT1 and 4726_AT1 and 4696_AT1 and 4712_AT2 and 4716_AT1 and 4725_AT1 and 4713_AT1 and 4723_AT1 and 4714_AT1 and 4535_AT1 and 4539_AT1 and 4702_AT1 and 4711_AT1 and 4541_AT1 and 4706_AT1 and 4715_AT1 and 4710_AT1 and 4700_AT1 and 4538_AT1 and 4540_AT1 and 126328_AT1 and 4717_AT1 and 4698_AT1 and 4724_AT1 and 4701_AT1 and 4719_AT1) or (4715_AT1 and 4710_AT1 and 4700_AT1 and 4535_AT1 and 4539_AT1 and 4702_AT1 and 4706_AT1 and 4711_AT1 and 4541_AT1 and 4714_AT1 and 4713_AT1 and 4723_AT1 and 4719_AT1 and 4698_AT1 and 4724_AT1 and 4701_AT1 and 4538_AT1 and 4540_AT1 and 4717_AT1 and 126328_AT1 and 4709_AT1 and 4697_AT1 and 4695_AT1 and 55967_AT1 and 4729_AT1 and 4720_AT1 and 4708_AT1 and 4728_AT1 and 4712_AT2 and 4716_AT1 and 4725_AT1 and 4694_AT1 and 4718_AT1 and 4707_AT1 and 4726_AT1 and 4696_AT1 and 7991_AT2 and 4731_AT2 and 4537_AT1 and 4704_AT1 and 4705_AT1 and 51079_AT1 and 374291_AT1 and 4722_AT1 and 4536_AT1) or (4719_AT1 and 4538_AT1 and 126328_AT1 and 4717_AT1 and 4540_AT1 and 4698_AT1 and 4701_AT1 and 4724_AT1 and 4702_AT1 and 4535_AT1 and 4539_AT1 and 4541_AT1 and 4711_AT1 and 4706_AT1 and 4712_AT1 and 4710_AT1 and 4715_AT1 and 4700_AT1 and 4713_AT1 and 4723_AT1 and 4714_AT1 and 4707_AT1 and 4718_AT1 and 4694_AT1 and 4696_AT1 and 4726_AT1 and 4725_AT1 and 4716_AT1 and 374291_AT1 and 51079_AT1 and 4722_AT1 and 4536_AT1 and 7991_AT2 and 4704_AT1 and 4705_AT1 and 4537_AT1 and 4731_AT2 and 4695_AT1 and 55967_AT1 and 4729_AT1 and 4709_AT1 and 4697_AT1 and 4728_AT1 and 4708_AT1 and 4720_AT1) or (4725_AT1 and 4716_AT1 and 4694_AT1 and 4707_AT1 and 4718_AT1 and 4696_AT1 and 4726_AT1 and 7991_AT2 and 4704_AT1 and 4705_AT1 and 4537_AT1 and 374291_AT1 and 51079_AT1 and 4722_AT1 and 4536_AT1 and 4709_AT1 and 4697_AT1 and 55967_AT1 and 4695_AT1 and 4729_AT1 and 4720_AT1 and 4708_AT1 and 4728_AT1 and 4719_AT1 and 4698_AT1 and 4701_AT1 and 4724_AT1 and 4538_AT1 and 4717_AT1 and 126328_AT1 and 4540_AT1 and 4715_AT1 and 4710_AT1 and 4700_AT1 and 4535_AT1 and 4702_AT1 and 4539_AT1 and 4711_AT1 and 4706_AT1 and 4541_AT1 and 4712_AT1 and 4731_AT1 and 4714_AT1 and 4713_AT1 and 4723_AT1) or (4723_AT1 and 4713_AT1 and 4714_AT1 and 4731_AT1 and 4712_AT1 and 4541_AT1 and 4711_AT1 and 4706_AT1 and 4535_AT1 and 4702_AT1 and 4539_AT1 and 4700_AT1 and 4715_AT1 and 4710_AT1 and 4540_AT1 and 4717_AT1 and 126328_AT1 and 4538_AT1 and 4701_AT1 and 4724_AT1 and 4698_AT1 and 4719_AT1 and 4728_AT1 and 4720_AT1 and 4708_AT1 and 4729_AT1 and 4695_AT1 and 55967_AT1 and 4697_AT1 and 4709_AT1 and 4536_AT1 and 4722_AT1 and 51079_AT1 and 7991_AT1 and 374291_AT1 and 4537_AT1 and 4704_AT1 and 4705_AT1 and 4726_AT1 and 4696_AT1 and 4694_AT1 and 4707_AT1 and 4718_AT1 and 4716_AT1 and 4725_AT1) or (4716_AT1 and 4725_AT1 and 4726_AT1 and 4696_AT1 and 4694_AT1 and 4718_AT1 and 4707_AT1 and 4537_AT1 and 4731_AT2 and 4705_AT1 and 4704_AT1 and 4722_AT1 and 4536_AT1 and 51079_AT1 and 7991_AT1 and 374291_AT1 and 4697_AT1 and 4709_AT1 and 4729_AT1 and 4695_AT1 and 55967_AT1 and 4708_AT1 and 4720_AT1 and 4728_AT1 and 4719_AT1 and 4701_AT1 and 4724_AT1 and 4698_AT1 and 4540_AT1 and 4717_AT1 and 126328_AT1 and 4538_AT1 and 4700_AT1 and 4715_AT1 and 4710_AT1 and 4712_AT1 and 4706_AT1 and 4541_AT1 and 4711_AT1 and 4702_AT1 and 4535_AT1 and 4539_AT1 and 4714_AT1 and 4723_AT1 and 4713_AT1) or (4711_AT1 and 4541_AT1 and 4706_AT1 and 4731_AT1 and 4535_AT1 and 4539_AT1 and 4702_AT1 and 4700_AT1 and 4710_AT1 and 4715_AT1 and 4723_AT1 and 4713_AT1 and 4714_AT1 and 4719_AT1 and 4717_AT1 and 126328_AT1 and 4540_AT1 and 4538_AT1 and 4724_AT1 and 4701_AT1 and 4698_AT1 and 4729_AT1 and 55967_AT1 and 4695_AT1 and 4697_AT1 and 4709_AT1 and 4728_AT1 and 4708_AT1 and 4720_AT1 and 4696_AT1 and 4726_AT1 and 4718_AT1 and 4707_AT1 and 4694_AT1 and 4725_AT1 and 4716_AT1 and 4712_AT2 and 4536_AT1 and 4722_AT1 and 7991_AT1 and 374291_AT1 and 51079_AT1 and 4705_AT1 and 4704_AT1 and 4537_AT1)", +"subsystem":"Oxidative Phosphorylation", +"notes":{ +"original_bigg_ids":[ +"NADH2_u10m" +] +} +}, +{ +"id":"NADHtpu", +"name":"NADH transporter, peroxisome", +"metabolites":{ +"nadh_c":-1.0, +"nadh_x":1.0 +}, +"lower_bound":0.0, +"upper_bound":999999.0, +"gene_reaction_rule":"", +"subsystem":"Transport, Peroxisomal", +"notes":{ +"original_bigg_ids":[ +"NADHtpu" +] +} +}, +{ +"id":"NADHtru", +"name":"NADH transporter, endoplasmic reticulum", +"metabolites":{ +"nadh_c":-1.0, +"nadh_r":1.0 +}, +"lower_bound":0.0, +"upper_bound":999999.0, +"gene_reaction_rule":"", +"subsystem":"Transport, Endoplasmic Reticular", +"notes":{ +"original_bigg_ids":[ +"NADHtru" +] +} +}, +{ +"id":"NADK", +"name":"NAD kinase", +"metabolites":{ +"adp_c":1.0, +"atp_c":-1.0, +"h_c":1.0, +"nad_c":-1.0, +"nadp_c":1.0 +}, +"lower_bound":0.0, +"upper_bound":999999.0, +"gene_reaction_rule":"65220_AT1", +"subsystem":"NAD Metabolism", +"notes":{ +"original_bigg_ids":[ +"NADK" +] +} +}, +{ +"id":"NADN", +"name":"NAD nucleosidase", +"metabolites":{ +"adprib_c":1.0, +"h2o_c":-1.0, +"h_c":1.0, +"nad_c":-1.0, +"ncam_c":1.0 +}, +"lower_bound":0.0, +"upper_bound":999999.0, +"gene_reaction_rule":"", +"subsystem":"NAD Metabolism", +"notes":{ +"original_bigg_ids":[ +"NADN" +] +} +}, +{ +"id":"NADNe", +"name":"NAD nucleosidase,extracellular", +"metabolites":{ +"adprib_e":1.0, +"h2o_e":-1.0, +"h_e":1.0, +"nad_e":-1.0, +"ncam_e":1.0 +}, +"lower_bound":0.0, +"upper_bound":999999.0, +"gene_reaction_rule":"952_AT1", +"subsystem":"NAD Metabolism", +"notes":{ +"original_bigg_ids":[ +"NADNe" +] +} +}, +{ +"id":"NADPHtru", +"name":"NADPH transporter, endoplasmic reticulum", +"metabolites":{ +"nadph_c":-1.0, +"nadph_r":1.0 +}, +"lower_bound":0.0, +"upper_bound":999999.0, +"gene_reaction_rule":"", +"subsystem":"Transport, Endoplasmic Reticular", +"notes":{ +"original_bigg_ids":[ +"NADPHtru" +] +} +}, +{ +"id":"NADPHtxu", +"name":"NADPH transport, glyoxysome", +"metabolites":{ +"nadph_c":-1.0, +"nadph_x":1.0 +}, +"lower_bound":0.0, +"upper_bound":999999.0, +"gene_reaction_rule":"", +"subsystem":"Transport, Peroxisomal", +"notes":{ +"original_bigg_ids":[ +"NADPHtxu" +] +} +}, +{ +"id":"NADPN", +"name":"NADP nucleosidase", +"metabolites":{ +"adprbp_c":1.0, +"h2o_c":-1.0, +"h_c":1.0, +"nadp_c":-1.0, +"ncam_c":1.0 +}, +"lower_bound":0.0, +"upper_bound":999999.0, +"gene_reaction_rule":"", +"subsystem":"NAD Metabolism", +"notes":{ +"original_bigg_ids":[ +"NADPN" +] +} +}, +{ +"id":"NADPNe", +"name":"NADP nucleosidase,extracellular", +"metabolites":{ +"adprbp_e":1.0, +"h2o_e":-1.0, +"h_e":1.0, +"nadp_e":-1.0, +"ncam_e":1.0 +}, +"lower_bound":0.0, +"upper_bound":999999.0, +"gene_reaction_rule":"952_AT1", +"subsystem":"NAD Metabolism", +"notes":{ +"original_bigg_ids":[ +"NADPNe" +] +} +}, +{ +"id":"NADPtru", +"name":"NADP transporter, endoplasmic reticulum", +"metabolites":{ +"nadp_c":1.0, +"nadp_r":-1.0 +}, +"lower_bound":0.0, +"upper_bound":999999.0, +"gene_reaction_rule":"", +"subsystem":"Transport, Endoplasmic Reticular", +"notes":{ +"original_bigg_ids":[ +"NADPtru" +] +} +}, +{ +"id":"NADPtxu", +"name":"NADP transport, glyoxysome", +"metabolites":{ +"nadp_c":1.0, +"nadp_x":-1.0 +}, +"lower_bound":0.0, +"upper_bound":999999.0, +"gene_reaction_rule":"", +"subsystem":"Transport, Peroxisomal", +"notes":{ +"original_bigg_ids":[ +"NADPtxu" +] +} +}, +{ +"id":"NADS2", +"name":"Nicotinate-mononucleotide adenylyltransferase", +"metabolites":{ +"amp_c":1.0, +"atp_c":-1.0, +"dnad_c":-1.0, +"gln__L_c":-1.0, +"glu__L_c":1.0, +"h2o_c":-1.0, +"h_c":1.0, +"nad_c":1.0, +"ppi_c":1.0 +}, +"lower_bound":0.0, +"upper_bound":999999.0, +"gene_reaction_rule":"55191_AT1", +"subsystem":"NAD Metabolism", +"notes":{ +"original_bigg_ids":[ +"NADS2" +] +} +}, +{ +"id":"NADtn", +"name":"NAD transport nuclear through pores", +"metabolites":{ +"nad_c":1.0, +"nad_n":-1.0 +}, +"lower_bound":-999999.0, +"upper_bound":999999.0, +"gene_reaction_rule":"", +"subsystem":"Transport, Nuclear", +"notes":{ +"original_bigg_ids":[ +"NADtn" +] +} +}, +{ +"id":"NADtpu", +"name":"NAD transporter, peroxisome", +"metabolites":{ +"nadh_c":1.0, +"nadh_x":-1.0 +}, +"lower_bound":0.0, +"upper_bound":999999.0, +"gene_reaction_rule":"", +"subsystem":"Transport, Peroxisomal", +"notes":{ +"original_bigg_ids":[ +"NADtpu" +] +} +}, +{ +"id":"NADtru", +"name":"NAD transporter, endoplasmic reticulum", +"metabolites":{ +"nad_c":1.0, +"nad_r":-1.0 +}, +"lower_bound":0.0, +"upper_bound":999999.0, +"gene_reaction_rule":"", +"subsystem":"Transport, Endoplasmic Reticular", +"notes":{ +"original_bigg_ids":[ +"NADtru" +] +} +}, +{ +"id":"NAGA2ly", +"name":"N-acetylgalactosaminidase, alpha-", +"metabolites":{ +"Ser_Thr_l":1.0, +"Tn_antigen_l":-1.0, +"h_l":-1.0, +"udp_l":-1.0, +"udpacgal_l":1.0 +}, +"lower_bound":0.0, +"upper_bound":999999.0, +"gene_reaction_rule":"4668_AT1", +"subsystem":"Keratan sulfate degradation", +"notes":{ +"original_bigg_ids":[ +"NAGA2ly" +] +} +}, +{ +"id":"NAGAlby", +"name":"N-acetylgalactosaminidase, beta-", +"metabolites":{ +"acgbgbside_hs_l":-1.0, +"gbside_hs_l":1.0, +"h_l":-1.0, +"udp_l":-1.0, +"udpacgal_l":1.0 +}, +"lower_bound":0.0, +"upper_bound":999999.0, +"gene_reaction_rule":"", +"subsystem":"Sphingolipid Metabolism", +"notes":{ +"original_bigg_ids":[ +"NAGAlby" +] +} +}, +{ +"id":"NAGAly", +"name":"N-acetylgalactosaminidase, alpha-", +"metabolites":{ +"acgagbside_hs_l":-1.0, +"gbside_hs_l":1.0, +"h_l":-1.0, +"udp_l":-1.0, +"udpacgal_l":1.0 +}, +"lower_bound":0.0, +"upper_bound":999999.0, +"gene_reaction_rule":"4668_AT1", +"subsystem":"Sphingolipid Metabolism", +"notes":{ +"original_bigg_ids":[ +"NAGAly" +] +} +}, +{ +"id":"NAGLCAly", +"name":"N-acetylglucosaminidase, lysosomal", +"metabolites":{ +"Tn_antigen_l":1.0, +"acgam_l":1.0, +"core6_l":-1.0, +"h2o_l":-1.0 +}, +"lower_bound":0.0, +"upper_bound":999999.0, +"gene_reaction_rule":"", +"subsystem":"Keratan sulfate degradation", +"notes":{ +"original_bigg_ids":[ +"NAGLCAly" +] +} +}, +{ +"id":"NAHCO3_HCLt", +"name":"Bicarbonate transport (HCl/NaHCO3 exchange)", +"metabolites":{ +"cl_c":-1.0, +"cl_e":1.0, +"h_c":-1.0, +"h_e":1.0, +"hco3_c":1.0, +"hco3_e":-1.0, +"na1_c":1.0, +"na1_e":-1.0 +}, +"lower_bound":-999999.0, +"upper_bound":999999.0, +"gene_reaction_rule":"57282_AT1 or 9498_AT1", +"subsystem":"Transport, Extracellular", +"notes":{ +"original_bigg_ids":[ +"NAHCO3_HCLt" +] +} +}, +{ +"id":"NAIt", +"name":"Na+ / iodide cotransport", +"metabolites":{ +"i_c":1.0, +"i_e":-1.0, +"na1_c":2.0, +"na1_e":-2.0 +}, +"lower_bound":-999999.0, +"upper_bound":999999.0, +"gene_reaction_rule":"6528_AT1", +"subsystem":"Transport, Extracellular", +"notes":{ +"original_bigg_ids":[ +"NAIt" +] +} +}, +{ +"id":"NAt", +"name":"Sodium transport (uniport)", +"metabolites":{ +"na1_c":1.0, +"na1_e":-1.0 +}, +"lower_bound":-999999.0, +"upper_bound":999999.0, +"gene_reaction_rule":"6523_AT1 or 6526_AT1 or 6528_AT1", +"subsystem":"Transport, Extracellular", +"notes":{ +"original_bigg_ids":[ +"NAt" +] +} +}, +{ +"id":"NAt3_1", +"name":"Sodium proton antiporter HNA is 11 ", +"metabolites":{ +"h_c":1.0, +"h_e":-1.0, +"na1_c":-1.0, +"na1_e":1.0 +}, +"lower_bound":-999999.0, +"upper_bound":999999.0, +"gene_reaction_rule":"6549_AT1 or 6550_AT1 or 389015_AT1 or 6553_AT1 or 6548_AT1", +"subsystem":"Transport, Extracellular", +"notes":{ +"original_bigg_ids":[ +"NAt3_1" +] +} +}, +{ +"id":"NAt3_1g", +"name":"Sodium proton antiporter (H:NA is 1:1)", +"metabolites":{ +"h_c":1.0, +"h_g":-1.0, +"na1_c":-1.0, +"na1_g":1.0 +}, +"lower_bound":-999999.0, +"upper_bound":999999.0, +"gene_reaction_rule":"84679_AT1 or 23315_AT1", +"subsystem":"Transport, Golgi Apparatus", +"notes":{ +"original_bigg_ids":[ +"NAt3_1g" +] +} +}, +{ +"id":"NAt5", +"name":"Sodium/ammonium proton antiporter", +"metabolites":{ +"na1_c":-1.0, +"na1_e":1.0, +"nh4_c":1.0, +"nh4_e":-1.0 +}, +"lower_bound":-999999.0, +"upper_bound":999999.0, +"gene_reaction_rule":"6550_AT1 or 6549_AT1 or 6548_AT1", +"subsystem":"Transport, Extracellular", +"notes":{ +"original_bigg_ids":[ +"NAt5" +] +} +}, +{ +"id":"NAtx", +"name":"Sodium transport via diffusion (perioxisome)", +"metabolites":{ +"na1_c":-1.0, +"na1_x":1.0 +}, +"lower_bound":-999999.0, +"upper_bound":999999.0, +"gene_reaction_rule":"", +"subsystem":"Transport, Peroxisomal", +"notes":{ +"original_bigg_ids":[ +"NAtx" +] +} +}, +{ +"id":"NBAHH_ir", +"name":"Nalpha-(beta-alanyl)-L-histidine hydrolase IR", +"metabolites":{ +"ala_B_c":1.0, +"carn_c":-1.0, +"h2o_c":-1.0, +"his__L_c":1.0 +}, +"lower_bound":0.0, +"upper_bound":999999.0, +"gene_reaction_rule":"84735_AT1", +"subsystem":"beta-Alanine metabolism", +"notes":{ +"original_bigg_ids":[ +"NBAHH_ir" +] +} +}, +{ +"id":"NCAMUP", +"name":"Nicotinamide acid uptake", +"metabolites":{ +"ncam_c":1.0, +"ncam_e":-1.0 +}, +"lower_bound":0.0, +"upper_bound":999999.0, +"gene_reaction_rule":"", +"subsystem":"Transport, Extracellular", +"notes":{ +"original_bigg_ids":[ +"NCAMUP" +] +} +}, +{ +"id":"NCCt", +"name":"Na+-Cl- cotransport", +"metabolites":{ +"cl_c":1.0, +"cl_e":-1.0, +"na1_c":1.0, +"na1_e":-1.0 +}, +"lower_bound":0.0, +"upper_bound":999999.0, +"gene_reaction_rule":"6559_AT1", +"subsystem":"Transport, Extracellular", +"notes":{ +"original_bigg_ids":[ +"NCCt" +] +} +}, +{ +"id":"NCKt", +"name":"Na+/Ca2+-K+ exchange", +"metabolites":{ +"ca2_c":1.0, +"ca2_e":-1.0, +"k_c":1.0, +"k_e":-1.0, +"na1_c":-4.0, +"na1_e":4.0 +}, +"lower_bound":-999999.0, +"upper_bound":999999.0, +"gene_reaction_rule":"123041_AT1 or 57419_AT1 or 123041_AT2 or 123041_AT3 or 9187_AT1 or 25769_AT1", +"subsystem":"Transport, Extracellular", +"notes":{ +"original_bigg_ids":[ +"NCKt" +] +} +}, +{ +"id":"NCNt", +"name":"Na+/Ca2+-NH4+ exchange", +"metabolites":{ +"ca2_c":1.0, +"ca2_e":-1.0, +"na1_c":-4.0, +"na1_e":4.0, +"nh4_c":1.0, +"nh4_e":-1.0 +}, +"lower_bound":-999999.0, +"upper_bound":999999.0, +"gene_reaction_rule":"25769_AT1 or 9187_AT1", +"subsystem":"Transport, Extracellular", +"notes":{ +"original_bigg_ids":[ +"NCNt" +] +} +}, +{ +"id":"NDP10ex", +"name":"Nucleoside-diphosphatase (IDP), extracellular", +"metabolites":{ +"h2o_e":-1.0, +"h_e":1.0, +"idp_e":-1.0, +"imp_e":1.0, +"pi_e":1.0 +}, +"lower_bound":0.0, +"upper_bound":999999.0, +"gene_reaction_rule":"124583_AT1", +"subsystem":"Nucleotides", +"notes":{ +"original_bigg_ids":[ +"NDP10ex" +] +} +}, +{ +"id":"NDP3ex", +"name":"Nucleoside-diphosphatase (GDP), extracellular", +"metabolites":{ +"gdp_e":-1.0, +"gmp_e":1.0, +"h2o_e":-1.0, +"h_e":1.0, +"pi_e":1.0 +}, +"lower_bound":0.0, +"upper_bound":999999.0, +"gene_reaction_rule":"124583_AT1", +"subsystem":"Nucleotides", +"notes":{ +"original_bigg_ids":[ +"NDP3ex" +] +} +}, +{ +"id":"NDP6", +"name":"Nucleoside-diphosphatase (dCDP)", +"metabolites":{ +"dcdp_c":-1.0, +"dcmp_c":1.0, +"h2o_c":-1.0, 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+"lower_bound":0.0, +"upper_bound":999999.0, +"gene_reaction_rule":"9583_AT1", +"subsystem":"Nucleotides", +"notes":{ +"original_bigg_ids":[ +"NDP7g" +] +} +}, +{ +"id":"NDP8", +"name":"Nucleoside-diphosphatase (dUDP)", +"metabolites":{ +"dudp_c":-1.0, +"dump_c":1.0, +"h2o_c":-1.0, +"h_c":1.0, +"pi_c":1.0 +}, +"lower_bound":0.0, +"upper_bound":999999.0, +"gene_reaction_rule":"1841_AT1", +"subsystem":"Nucleotides", +"notes":{ +"original_bigg_ids":[ +"NDP8" +] +} +}, +{ +"id":"NDP8ex", +"name":"Nucleoside-diphosphatase (UTP), extracellular", +"metabolites":{ +"h2o_e":-1.0, +"h_e":1.0, +"pi_e":1.0, +"udp_e":1.0, +"utp_e":-1.0 +}, +"lower_bound":0.0, +"upper_bound":999999.0, +"gene_reaction_rule":"124583_AT1", +"subsystem":"Nucleotides", +"notes":{ +"original_bigg_ids":[ +"NDP8ex" +] +} +}, +{ +"id":"NDPK1", +"name":"Nucleoside-diphosphate kinase (ATP:GDP)", +"metabolites":{ +"adp_c":1.0, +"atp_c":-1.0, +"gdp_c":-1.0, +"gtp_c":1.0 +}, +"lower_bound":-999999.0, +"upper_bound":999999.0, 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5279_AT2 and 5277_AT3 and 5283_AT1 and 51227_AT2) or (51227_AT3 and 5283_AT1 and 8818_AT1 and 5279_AT1 and 5277_AT1 and 9091_AT1) or (5279_AT2 and 8818_AT1 and 5277_AT1 and 9091_AT2 and 51227_AT3 and 5283_AT1) or (5277_AT3 and 5283_AT1 and 9091_AT2 and 51227_AT1 and 5279_AT1 and 8818_AT1) or (5277_AT3 and 5283_AT1 and 51227_AT2 and 9091_AT1 and 5279_AT1 and 8818_AT2) or (8818_AT1 and 5279_AT1 and 5277_AT2 and 9091_AT2 and 5283_AT1 and 51227_AT3) or (5277_AT2 and 9091_AT1 and 5279_AT1 and 8818_AT1 and 51227_AT2 and 5283_AT1) or (51227_AT3 and 5283_AT1 and 5279_AT2 and 8818_AT1 and 9091_AT1 and 5277_AT1) or (5277_AT3 and 9091_AT2 and 5283_AT1 and 51227_AT2 and 5279_AT1 and 8818_AT2) or (5283_AT1 and 9091_AT2 and 51227_AT1 and 5277_AT2 and 5279_AT1 and 8818_AT2) or (8818_AT2 and 9091_AT1 and 5279_AT1 and 5277_AT2 and 51227_AT1 and 5283_AT1) or (5277_AT2 and 9091_AT1 and 5279_AT2 and 8818_AT1 and 5283_AT1 and 51227_AT1) or (8818_AT2 and 9091_AT1 and 5279_AT1 and 5277_AT1 and 51227_AT1 and 5283_AT1) or (5277_AT1 and 5279_AT2 and 8818_AT2 and 51227_AT2 and 9091_AT2 and 5283_AT1) or (8818_AT1 and 5279_AT2 and 5277_AT2 and 9091_AT1 and 51227_AT2 and 5283_AT1) or (5277_AT3 and 5283_AT1 and 51227_AT1 and 8818_AT2 and 9091_AT1 and 5279_AT1) or (9091_AT2 and 51227_AT1 and 5283_AT1 and 5277_AT2 and 5279_AT2 and 8818_AT1) or (5279_AT2 and 8818_AT2 and 9091_AT1 and 5277_AT1 and 5283_AT1 and 51227_AT1) or (5277_AT3 and 51227_AT1 and 5283_AT1 and 9091_AT2 and 5279_AT2 and 8818_AT2) or (5283_AT1 and 9091_AT2 and 51227_AT3 and 5277_AT3 and 8818_AT2 and 5279_AT2) or (5277_AT3 and 5283_AT1 and 51227_AT2 and 9091_AT1 and 5279_AT2 and 8818_AT1) or (8818_AT1 and 5279_AT2 and 9091_AT1 and 5277_AT2 and 51227_AT3 and 5283_AT1) or (5277_AT1 and 5279_AT1 and 8818_AT2 and 9091_AT2 and 5283_AT1 and 51227_AT2) or (8818_AT1 and 9091_AT1 and 5279_AT1 and 51227_AT1 and 5283_AT1 and 5277_AT3) or (5283_AT1 and 51227_AT3 and 9091_AT2 and 5277_AT3 and 8818_AT1 and 5279_AT1) or (9091_AT1 and 8818_AT1 and 5279_AT2 and 51227_AT1 and 5277_AT3 and 5283_AT1) or (51227_AT1 and 5283_AT1 and 9091_AT2 and 8818_AT2 and 5277_AT1 and 5279_AT1) or (5279_AT1 and 5277_AT1 and 9091_AT1 and 8818_AT2 and 5283_AT1 and 51227_AT3) or (8818_AT1 and 5279_AT1 and 5277_AT2 and 9091_AT2 and 5283_AT1 and 51227_AT1) or (5283_AT1 and 51227_AT3 and 5277_AT2 and 9091_AT1 and 5279_AT1 and 8818_AT1) or (5283_AT1 and 51227_AT1 and 8818_AT1 and 5277_AT1 and 5279_AT1 and 9091_AT1) or (9091_AT2 and 5277_AT3 and 51227_AT1 and 5283_AT1 and 8818_AT1 and 5279_AT2) or (51227_AT3 and 5283_AT1 and 9091_AT2 and 5277_AT2 and 8818_AT1 and 5279_AT2) or (5277_AT2 and 9091_AT1 and 5279_AT1 and 8818_AT2 and 51227_AT3 and 5283_AT1) or (5283_AT1 and 51227_AT1 and 5277_AT2 and 9091_AT1 and 5279_AT1 and 8818_AT1) or (8818_AT1 and 9091_AT1 and 5279_AT1 and 5277_AT2 and 5283_AT1 and 51227_AT2) or (5277_AT2 and 5279_AT2 and 8818_AT1 and 51227_AT2 and 5283_AT1 and 9091_AT2) or (5279_AT2 and 8818_AT1 and 9091_AT1 and 5277_AT3 and 5283_AT1 and 51227_AT3) or (5283_AT1 and 5277_AT3 and 51227_AT3 and 5279_AT2 and 8818_AT2 and 9091_AT1) or (5279_AT2 and 8818_AT1 and 51227_AT3 and 5277_AT3 and 9091_AT2 and 5283_AT1) or (5279_AT1 and 5277_AT2 and 8818_AT2 and 51227_AT3 and 5283_AT1 and 9091_AT2) or (8818_AT1 and 5277_AT1 and 5279_AT1 and 9091_AT2 and 51227_AT1 and 5283_AT1) or (9091_AT1 and 5277_AT1 and 8818_AT1 and 5279_AT2 and 5283_AT1 and 51227_AT1) or (5283_AT1 and 51227_AT2 and 5279_AT1 and 9091_AT1 and 5277_AT1 and 8818_AT2) or (5277_AT2 and 8818_AT2 and 5279_AT2 and 9091_AT2 and 5283_AT1 and 51227_AT2) or (51227_AT1 and 5283_AT1 and 5279_AT2 and 8818_AT2 and 5277_AT2 and 9091_AT1)", +"subsystem":"Glycosylphosphatidylinositol (GPI)-anchor biosynthesis", +"notes":{ +"original_bigg_ids":[ +"PIACGT" +] +} +}, +{ +"id":"PIK3", +"name":"Phosphatidylinositol 3-kinase", +"metabolites":{ +"adp_c":1.0, +"atp_c":-1.0, +"h_c":1.0, +"pail3p_hs_c":1.0, +"pail_hs_c":-1.0 +}, +"lower_bound":0.0, +"upper_bound":999999.0, 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space", +"g":"golgi apparatus", +"l":"lysosome", +"m":"mitochondria", +"n":"nucleus", +"r":"endoplasmic reticulum", +"x":"peroxisome/glyoxysome" +}, +"version":"1" +} \ No newline at end of file diff --git a/1-0-0/6/models/Saccharomyces cerevisiae/iMM904.json b/1-0-0/6/models/Saccharomyces cerevisiae/iMM904.json index cef40981..e0b6b863 100644 --- a/1-0-0/6/models/Saccharomyces cerevisiae/iMM904.json +++ b/1-0-0/6/models/Saccharomyces cerevisiae/iMM904.json @@ -1 +1,53541 @@ -{"reactions": [{"subsystem": "S_Starch_and_Sucrose_Metabolism", "name": "Endo 1 3 beta glucan glucohydrase", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["13BGH"]}, "metabolites": {"13BDglcn_c": -1.0, "glc__D_c": 1.0, "h2o_c": -1.0}, "id": "13BGH", "gene_reaction_rule": "YGR282C"}, {"subsystem": "S_Starch_and_Sucrose_Metabolism", "name": "Exo 1 3 beta glucan glucohydrase", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["13BGHe"]}, "metabolites": 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{"subsystem": "S_Alternate_Carbon_Metabolism", "name": "1 6 beta glucan synthase", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["16GS"]}, "metabolites": {"16BDglcn_c": 1.0, "udp_c": 1.0, "udpg_c": -1.0, "h_c": 1.0}, "id": "16GS", "gene_reaction_rule": "YPR159W or YGR143W"}, {"subsystem": "S_Other", "name": "ADP ribose 2 3 cyclic phosphodiesterase", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["23CAPPD"]}, "metabolites": {"h2o_c": -1.0, "23camp_c": -1.0, "h_c": -1.0, "amp2p_c": 1.0}, "id": "23CAPPD", "gene_reaction_rule": "YGR247W"}, {"subsystem": "S_Transport__Mitochondrial", "name": "2 Dehydro 3 deoxy D arabino heptonate7 phohsphate mitochondrial transport via diffusion", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["2DDA7Ptm"]}, "metabolites": {"2dda7p_m": 1.0, "2dda7p_c": -1.0}, "id": "2DDA7Ptm", "gene_reaction_rule": ""}, {"subsystem": "S_Transport__Mitochondrial", "name": "2 Dehydropantoate mitochondrial transport", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["2DHPtm"]}, "metabolites": {"2dhp_m": 1.0, "2dhp_c": -1.0}, "id": "2DHPtm", "gene_reaction_rule": ""}, {"subsystem": "S_Other", "name": "2 deoxyglucose 6 phosphatase", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["2DOXG6PP"]}, "metabolites": {"2doxg6p_c": -1.0, "h2o_c": -1.0, "2dglc_c": 1.0, "pi_c": 1.0}, "id": "2DOXG6PP", "gene_reaction_rule": "YHR044C or YHR043C"}, {"subsystem": "S_Cysteine_Metabolism", "name": "2 HydroxybutyrateNAD oxidoreductase", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["2HBO"]}, "metabolites": {"2obut_c": 1.0, "nadh_c": 1.0, "h_c": 1.0, "nad_c": -1.0, "2hb_c": -1.0}, "id": "2HBO", "gene_reaction_rule": ""}, {"subsystem": "S_Cysteine_Metabolism", "name": "2 hydroxybutyrate cotransport with proton", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": 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"name": "Guanylate kinase GMPdATP ", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["GK2"]}, "metabolites": {"datp_c": -1.0, "gmp_c": -1.0, "gdp_c": 1.0, "dadp_c": 1.0}, "id": "GK2", "gene_reaction_rule": "YDR454C"}, {"subsystem": "S_Alternate_Carbon_Metabolism", "name": "Glucan 1 4 alpha glucosidase", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLCGSD"]}, "metabolites": {"glc__D_c": 1.0, "h2o_c": -1.0, "glycogen_c": -1.0}, "id": "GLCGSD", "gene_reaction_rule": "YPR184W"}, {"subsystem": "S_Alternate_Carbon_Metabolism", "name": "Glucan 1 4 alpha glucosidase vacuole", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLCGSDv"]}, "metabolites": {"glycogen_v": -1.0, "glc__D_v": 1.0, "h2o_v": -1.0}, "id": "GLCGSDv", "gene_reaction_rule": "YIL099W"}, {"subsystem": "S_Transport__Vacuolar", "name": "Glycogen vacuolar transport via autophagy", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": 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1.0, "glc__D_e": -1.0}, "id": "GLCt1", "gene_reaction_rule": "YHR092C or YLR081W or YOL156W or YDR536W or YHR094C or YEL069C or YDL245C or YJR158W or YFL011W or YNR072W or YMR011W or YDR345C or YHR096C or YDR343C or YDR342C or YJL214W or YJL219W"}, {"subsystem": "S_Transport__Vacuolar", "name": "Glucose transport vacuolar", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["GLCtv"]}, "metabolites": {"glc__D_c": -1.0, "glc__D_v": 1.0}, "id": "GLCtv", "gene_reaction_rule": ""}, {"subsystem": "S_Glutamine_Metabolism", "name": "Glutamine synthetase", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLNS"]}, "metabolites": {"atp_c": -1.0, "glu__L_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "nh4_c": -1.0, "gln__L_c": 1.0}, "id": "GLNS", "gene_reaction_rule": "YPR035W"}, {"subsystem": "S_tRNA_charging", "name": "Glutaminyl-tRNA synthetase", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLNTRS"]}, "metabolites": {"glntrna_c": 1.0, "atp_c": -1.0, "trnagln_c": -1.0, "ppi_c": 1.0, "amp_c": 1.0, "gln__L_c": -1.0}, "id": "GLNTRS", "gene_reaction_rule": "YOR168W"}, {"subsystem": "S_Transport__Nuclear", "name": "Glutamine nuclear transport via proton symport", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["GLNt2n"]}, "metabolites": {"h_n": 1.0, "gln__L_n": 1.0, "h_c": -1.0, "gln__L_c": -1.0}, "id": "GLNt2n", "gene_reaction_rule": ""}, {"subsystem": "S_Transport__Extracellular", "name": "L glutamine reversible transport via proton symport", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["GLNt2r"]}, "metabolites": {"gln__L_e": -1.0, "h_e": -1.0, "h_c": 1.0, "gln__L_c": 1.0}, "id": "GLNt2r", "gene_reaction_rule": "YKR039W or YCL025C or YDR508C or YPL265W"}, {"subsystem": "S_Transport__Vacuolar", "name": "L glutamine transport in via proton antiport vacuolar ", "upper_bound": 999999.0, "lower_bound": 0.0, 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"leu__L_c"}, {"name": "L-Leucyl-tRNA(Leu)", "notes": {"original_bigg_ids": ["leutrna_c"]}, "charge": 1, "formula": "C6H12NOR", "compartment": "c", "id": "leutrna_c"}, {"name": "(R)-S-Lactoylglutathione", "notes": {"original_bigg_ids": ["lgt_S_c"]}, "charge": -1, "formula": "C13H20N3O8S", "compartment": "c", "id": "lgt__S_c"}, {"name": "L-Lysine", "notes": {"original_bigg_ids": ["lys_L_c"]}, "charge": 1, "formula": "C6H15N2O2", "compartment": "c", "id": "lys__L_c"}, {"name": "L-Lysine-tRNA (Lys)", "notes": {"original_bigg_ids": ["lystrna_c"]}, "charge": 2, "formula": "C6H14N2OR", "compartment": "c", "id": "lystrna_c"}, {"name": "L-Malate", "notes": {"original_bigg_ids": ["mal_L_c"]}, "charge": -2, "formula": "C4H4O5", "compartment": "c", "id": "mal__L_c"}, {"name": "Malonyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["malACP_c"]}, "charge": -2, "formula": "C14H22N2O10PRS", "compartment": "c", "id": "malACP_c"}, {"name": "Malonyl-CoA", "notes": {"original_bigg_ids": 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"5,10-Methenyltetrahydrofolate", "notes": {"original_bigg_ids": ["methf_c"]}, "charge": -1, "formula": "C20H20N7O6", "compartment": "c", "id": "methf_c"}, {"name": "L-Methionyl-tRNA (Met)", "notes": {"original_bigg_ids": ["mettrna_c"]}, "charge": 1, "formula": "C5H10NOSR", "compartment": "c", "id": "mettrna_c"}, {"name": "1D-myo-Inositol 1-phosphate", "notes": {"original_bigg_ids": ["mi1p_D_c"]}, "charge": -2, "formula": "C6H11O9P", "compartment": "c", "id": "mi1p__D_c"}, {"name": "5,10-Methylenetetrahydrofolate", "notes": {"original_bigg_ids": ["mlthf_c"]}, "charge": -2, "formula": "C20H21N7O6", "compartment": "c", "id": "mlthf_c"}, {"name": "S-Methyl-L-methionine", "notes": {"original_bigg_ids": ["mmet_c"]}, "charge": 1, "formula": "C6H14NO2S", "compartment": "c", "id": "mmet_c"}, {"name": "Methylglyoxal", "notes": {"original_bigg_ids": ["mthgxl_c"]}, "charge": 0, "formula": "C3H4O2", "compartment": "c", "id": "mthgxl_c"}, {"name": "Myristoyl-ACP (n-C14:0ACP)", "notes": 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0, "formula": "C5H10O", "compartment": "c", "id": "2mbald_c"}, {"name": "2 methyl 1 butanol C5H12O", "notes": {"original_bigg_ids": ["2mbtoh_c"]}, "charge": 0, "formula": "C5H12O", "compartment": "c", "id": "2mbtoh_c"}, {"name": "2 methylpropanal C4H8O", "notes": {"original_bigg_ids": ["2mppal_c"]}, "charge": 0, "formula": "C4H8O", "compartment": "c", "id": "2mppal_c"}, {"name": "2 Oxoadipate C6H6O5", "notes": {"original_bigg_ids": ["2oxoadp_c"]}, "charge": -2, "formula": "C6H6O5", "compartment": "c", "id": "2oxoadp_c"}, {"name": "2 phenylethanol C8H10O", "notes": {"original_bigg_ids": ["2phetoh_c"]}, "charge": 0, "formula": "C8H10O", "compartment": "c", "id": "2phetoh_c"}, {"name": "3 5 Cyclic CMP C9H11N3O7P", "notes": {"original_bigg_ids": ["35ccmp_c"]}, "charge": -1, "formula": "C9H11N3O7P", "compartment": "c", "id": "35ccmp_c"}, {"name": "3 5 Cyclic dAMP C10H11N5O5P", "notes": {"original_bigg_ids": ["35cdamp_c"]}, "charge": -1, "formula": "C10H11N5O5P", "compartment": "c", "id": "35cdamp_c"}, {"name": "3 5 Cyclic IMP C10H10N4O7P", "notes": {"original_bigg_ids": ["35cimp_c"]}, "charge": -1, "formula": "C10H10N4O7P", "compartment": "c", "id": "35cimp_c"}, {"name": "3 Hexaprenyl 4 5 dihydroxybenzoate C37H53O4", "notes": {"original_bigg_ids": ["3dh5hpb_c"]}, "charge": -1, "formula": "C37H53O4", "compartment": "c", "id": "3dh5hpb_c"}, {"name": "3 Dehydrosphinganine C18H38NO2", "notes": {"original_bigg_ids": ["3dsphgn_c"]}, "charge": 1, "formula": "C18H38NO2", "compartment": "c", "id": "3dsphgn_c"}, {"name": "3 Hydroxyanthranilate C7H7NO3", "notes": {"original_bigg_ids": ["3hanthrn_c"]}, "charge": 0, "formula": "C7H7NO3", "compartment": "c", "id": "3hanthrn_c"}, {"name": "3 isopropylmalate methyl ester C8H13O5", "notes": {"original_bigg_ids": ["3ipmmest_c"]}, "charge": -1, "formula": "C8H13O5", "compartment": "c", "id": "3ipmmest_c"}, {"name": "3 Methylbutanal C5H10O", "notes": {"original_bigg_ids": ["3mbald_c"]}, "charge": 0, "formula": "C5H10O", "compartment": "c", "id": "3mbald_c"}, {"name": "3 Hexaprenyl 4 hydroxybenzoate C37H53O3", "notes": {"original_bigg_ids": ["3ophb_5_c"]}, "charge": -1, "formula": "C37H53O3", "compartment": "c", "id": "3ophb_5_c"}, {"name": "4 4 dimethylcholesta 8 14 24 trienol C29H46O", "notes": {"original_bigg_ids": ["44mctr_c"]}, "charge": 0, "formula": "C29H46O", "compartment": "c", "id": "44mctr_c"}, {"name": "4 4 dimethylzymosterol C29H48O", "notes": {"original_bigg_ids": ["44mzym_c"]}, "charge": 0, "formula": "C29H48O", "compartment": "c", "id": "44mzym_c"}, {"name": "4 Acetamidobutanoate C6H10NO3", "notes": {"original_bigg_ids": ["4aabutn_c"]}, "charge": -1, "formula": "C6H10NO3", "compartment": "c", "id": "4aabutn_c"}, {"name": "4 Fumarylacetoacetate C8H6O6", "notes": {"original_bigg_ids": ["4fumacac_c"]}, "charge": -2, "formula": "C8H6O6", "compartment": "c", "id": "4fumacac_c"}, {"name": "4 Guanidinobutanamide C5H13N4O", "notes": {"original_bigg_ids": ["4gudbd_c"]}, "charge": 1, "formula": "C5H13N4O", "compartment": "c", "id": "4gudbd_c"}, {"name": "4 Guanidinobutanoate C5H11N3O2", "notes": {"original_bigg_ids": ["4gudbutn_c"]}, "charge": 0, "formula": "C5H11N3O2", "compartment": "c", "id": "4gudbutn_c"}, {"name": "4 Hydroxy 2 oxoglutarate C5H4O6", "notes": {"original_bigg_ids": ["4h2oglt_c"]}, "charge": -2, "formula": "C5H4O6", "compartment": "c", "id": "4h2oglt_c"}, {"name": "Trans 4 Hydroxy L proline C5H9NO3", "notes": {"original_bigg_ids": ["4hpro_LT_c"]}, "charge": 0, "formula": "C5H9NO3", "compartment": "c", "id": "4hpro_LT_c"}, {"name": "4 Maleylacetoacetate C8H6O6", "notes": {"original_bigg_ids": ["4mlacac_c"]}, "charge": -2, "formula": "C8H6O6", "compartment": "c", "id": "4mlacac_c"}, {"name": "4 methylzymosterol C28H46O", "notes": {"original_bigg_ids": ["4mzym_c"]}, "charge": 0, "formula": "C28H46O", "compartment": "c", "id": "4mzym_c"}, {"name": "4 Methylzymosterol intermediate 1 C29H46O3", "notes": {"original_bigg_ids": ["4mzym_int1_c"]}, "charge": 0, "formula": "C29H46O3", "compartment": "c", "id": "4mzym_int1_c"}, {"name": "4 Methylzymosterol intermediate 2 C28H44O", "notes": {"original_bigg_ids": ["4mzym_int2_c"]}, "charge": 0, "formula": "C28H44O", "compartment": "c", "id": "4mzym_int2_c"}, {"name": " R 5 Diphosphomevalonate C6H10O10P2", "notes": {"original_bigg_ids": ["5dpmev_c"]}, "charge": -4, "formula": "C6H10O10P2", "compartment": "c", "id": "5dpmev_c"}, {"name": " R 5 Phosphomevalonate C6H10O7P", "notes": {"original_bigg_ids": ["5pmev_c"]}, "charge": -3, "formula": "C6H10O7P", "compartment": "c", "id": "5pmev_c"}, {"name": "D Gal alpha 1 6D Glucose C12H22O11", "notes": {"original_bigg_ids": ["6dg_c"]}, "charge": 0, "formula": "C12H22O11", "compartment": "c", "id": "6dg_c"}, {"name": "D Arabinono 1 4 lactone C5H8O5", "notes": {"original_bigg_ids": ["Dara14lac_c"]}, "charge": 0, "formula": "C5H8O5", "compartment": "c", "id": "Dara14lac_c"}, {"name": "L 2 Aminoadipate 6 semialdehyde C6H11NO3", "notes": {"original_bigg_ids": ["L2aadp6sa_c"]}, "charge": 0, "formula": "C6H11NO3", "compartment": "c", "id": "L2aadp6sa_c"}, {"name": "L 2 Aminoadipate C6H10NO4", "notes": {"original_bigg_ids": ["L2aadp_c"]}, "charge": -1, "formula": "C6H10NO4", "compartment": "c", "id": "L2aadp_c"}, {"name": "L Cystine C6H12N2O4S2", "notes": {"original_bigg_ids": ["Lcystin_c"]}, "charge": 0, "formula": "C6H12N2O4S2", "compartment": "c", "id": "Lcystin_c"}, {"name": "L Formylkynurenine C11H12N2O4", "notes": {"original_bigg_ids": ["Lfmkynr_c"]}, "charge": 0, "formula": "C11H12N2O4", "compartment": "c", "id": "Lfmkynr_c"}, {"name": "L Kynurenine C10H12N2O3", "notes": {"original_bigg_ids": ["Lkynr_c"]}, "charge": 0, "formula": "C10H12N2O3", "compartment": "c", "id": "Lkynr_c"}, {"name": "N1 Acetylspermine C12H31N4O", "notes": {"original_bigg_ids": ["N1sprm_c"]}, "charge": 3, "formula": "C12H31N4O", "compartment": "c", "id": "N1sprm_c"}, {"name": "N pai Methyl L histidine C7H11N3O2", "notes": {"original_bigg_ids": ["NPmehis_c"]}, "charge": 0, "formula": "C7H11N3O2", "compartment": "c", "id": "NPmehis_c"}, {"name": "N N bisformyl dityrosine C20H22N2O8", "notes": {"original_bigg_ids": ["Nbfortyr_c"]}, "charge": -2, "formula": "C20H22N2O8", "compartment": "c", "id": "Nbfortyr_c"}, {"name": "N Formyl L tyrosine C10H10NO4", "notes": {"original_bigg_ids": ["Nfortyr_c"]}, "charge": -1, "formula": "C10H10NO4", "compartment": "c", "id": "Nfortyr_c"}, {"name": " S Squalene 2 3 epoxide C30H50O", "notes": {"original_bigg_ids": ["Ssq23epx_c"]}, "charge": 0, "formula": "C30H50O", "compartment": "c", "id": "Ssq23epx_c"}, {"name": "L Arabinitol C5H12O5", "notes": {"original_bigg_ids": ["abt_c"]}, "charge": 0, "formula": "C5H12O5", "compartment": "c", "id": "abt_c"}, {"name": "Acetic ester C4H8O2", "notes": {"original_bigg_ids": ["aces_c"]}, "charge": 0, "formula": "C4H8O2", "compartment": "c", "id": "aces_c"}, {"name": "O Acetyl L homoserine C6H11NO4", "notes": {"original_bigg_ids": ["achms_c"]}, "charge": 0, "formula": "C6H11NO4", "compartment": "c", "id": "achms_c"}, {"name": "E 3 carboxyl 2 pentenedioate 5 methyl ester C7H6O6", "notes": {"original_bigg_ids": ["acon5m_c"]}, "charge": -2, "formula": "C7H6O6", "compartment": "c", "id": "acon5m_c"}, {"name": "O Acetylcarnitine C9H17NO4", "notes": {"original_bigg_ids": ["acrn_c"]}, "charge": 0, "formula": "C9H17NO4", "compartment": "c", "id": "acrn_c"}, {"name": " R Acetoin C4H8O2", "notes": {"original_bigg_ids": ["actn_R_c"]}, "charge": 0, "formula": "C4H8O2", "compartment": "c", "id": "actn__R_c"}, {"name": "Gamma Amino gamma cyanobutanoate C5H8N2O2", "notes": {"original_bigg_ids": ["acybut_c"]}, "charge": 0, "formula": "C5H8N2O2", "compartment": "c", "id": "acybut_c"}, {"name": "Allophanate C2H3N2O3", "notes": {"original_bigg_ids": ["allphn_c"]}, "charge": -1, "formula": "C2H3N2O3", "compartment": "c", "id": "allphn_c"}, {"name": "Adenosine 2 phosphate C10H14N5O7P", "notes": {"original_bigg_ids": ["amp2p_c"]}, "charge": 0, "formula": "C10H14N5O7P", "compartment": "c", "id": "amp2p_c"}, {"name": "P1 5 adenosyl P4 5 guanosyl tetraphosphate C20H24N10O20P4", "notes": {"original_bigg_ids": ["ap4g_c"]}, "charge": -4, "formula": "C20H24N10O20P4", "compartment": "c", "id": "ap4g_c"}, {"name": "Nalpha Acetylpeptide C6H7N2O4R2", "notes": {"original_bigg_ids": ["apep_c"]}, "charge": -1, "formula": "C6H7N2O4R2", "compartment": "c", "id": "apep_c"}, {"name": "3 Aminopropanal C3H8NO", "notes": {"original_bigg_ids": ["aproa_c"]}, "charge": 1, "formula": "C3H8NO", "compartment": "c", "id": "aproa_c"}, {"name": "Alpha Aminopropiononitrile C3H7N2", "notes": {"original_bigg_ids": ["aprop_c"]}, "charge": 1, "formula": "C3H7N2", "compartment": "c", "id": "aprop_c"}, {"name": "N Acetylputrescine C6H15N2O", "notes": {"original_bigg_ids": ["aprut_c"]}, "charge": 1, "formula": "C6H15N2O", "compartment": "c", "id": "aprut_c"}, {"name": "D Arabinose C5H10O5", "notes": {"original_bigg_ids": ["arab_D_c"]}, "charge": 0, "formula": "C5H10O5", "compartment": "c", "id": "arab__D_c"}, {"name": "Biotinyl 5 AMP C20H27N7O9PS", "notes": {"original_bigg_ids": ["btamp_c"]}, "charge": -1, "formula": "C20H27N7O9PS", "compartment": "c", "id": "btamp_c"}, {"name": " R R 2 3 Butanediol C4H10O2", "notes": {"original_bigg_ids": ["btd_RR_c"]}, "charge": 0, "formula": "C4H10O2", "compartment": "c", "id": "btd_RR_c"}, {"name": "2 3 Carboxy 3 aminopropyl L histidine C10H16N4O4", "notes": {"original_bigg_ids": ["caphis_c"]}, "charge": 0, "formula": "C10H16N4O4", "compartment": "c", "id": "caphis_c"}, {"name": "CDPcholine C14H25N4O11P2", "notes": {"original_bigg_ids": ["cdpchol_c"]}, "charge": -1, "formula": "C14H25N4O11P2", "compartment": "c", "id": "cdpchol_c"}, {"name": "CDPdiacylglycerol yeast specific C4440H7744N300O1500P200", "notes": {"original_bigg_ids": ["cdpdag_SC_c"]}, "charge": -200, "formula": "C4440H7744N300O1500P200", "compartment": "c", "id": "cdpdag_SC_c"}, {"name": "CDPethanolamine C11H19N4O11P2", "notes": {"original_bigg_ids": ["cdpea_c"]}, "charge": -1, "formula": "C11H19N4O11P2", "compartment": "c", "id": "cdpea_c"}, {"name": "Ceramide 1 Sphinganinen C240 C42H85NO3", "notes": {"original_bigg_ids": ["cer1_24_c"]}, "charge": 0, "formula": "C42H85NO3", "compartment": "c", "id": "cer1_24_c"}, {"name": "Ceramide 1 Sphinganinen C260 C44H89NO3", "notes": {"original_bigg_ids": ["cer1_26_c"]}, "charge": 0, "formula": "C44H89NO3", "compartment": "c", "id": "cer1_26_c"}, {"name": "Ceramide 2 Phytosphingosinen C240 C42H85NO4", "notes": {"original_bigg_ids": ["cer2_24_c", "cer2__24_c"]}, "charge": 0, "formula": "C42H85NO4", "compartment": "c", "id": "cer2_24_c"}, {"name": "Ceramide 2 Phytosphingosinen C260 C44H89NO4", "notes": {"original_bigg_ids": ["cer2_26_c", "cer2__26_c"]}, "charge": 0, "formula": "C44H89NO4", "compartment": "c", "id": "cer2_26_c"}, {"name": "Ceramide 3 Phytosphingosinen C240OH C42H85NO5", "notes": {"original_bigg_ids": ["cer3_24_c"]}, "charge": 0, "formula": "C42H85NO5", "compartment": "c", "id": "cer3_24_c"}, {"name": "Ceramide 3 Phytosphingosinen C260OH C44H89NO5", "notes": {"original_bigg_ids": ["cer3_26_c"]}, "charge": 0, "formula": "C44H89NO5", "compartment": "c", "id": "cer3_26_c"}, {"name": "Methanethiol CH4S", "notes": {"original_bigg_ids": ["ch4s_c"]}, "charge": 0, "formula": "CH4S", "compartment": "c", "id": "ch4s_c"}, {"name": "Chitin monomer C8H13NO5", "notes": {"original_bigg_ids": ["chitin_c"]}, "charge": 0, "formula": "C8H13NO5", "compartment": "c", "id": "chitin_c"}, {"name": "Chitosan C6H11NO4", "notes": {"original_bigg_ids": ["chitos_c"]}, "charge": 0, "formula": "C6H11NO4", "compartment": "c", "id": "chitos_c"}, {"name": "Choline phosphate C5H13NO4P", "notes": {"original_bigg_ids": ["cholp_c"]}, "charge": -1, "formula": "C5H13NO4P", "compartment": "c", "id": "cholp_c"}, {"name": "2 3 Carboxy 3 methylammonio propyl L histidine C11H18N4O4", "notes": {"original_bigg_ids": ["cmaphis_c"]}, "charge": 0, "formula": "C11H18N4O4", "compartment": "c", "id": "cmaphis_c"}, {"name": "2 Amino 3 carboxymuconate semialdehyde C7H6NO5", "notes": {"original_bigg_ids": ["cmusa_c"]}, "charge": -1, "formula": "C7H6NO5", "compartment": "c", "id": "cmusa_c"}, {"name": "Diacylglycerol pyrophosphate yeast specific C3540H6544O1100P200", "notes": {"original_bigg_ids": ["dagpy_SC_c"]}, "charge": -300, "formula": "C3540H6544O1100P200", "compartment": "c", "id": "dagpy_SC_c"}, {"name": "Dolichol C15H28O", "notes": {"original_bigg_ids": ["dolichol_c"]}, "charge": 0, "formula": "C15H28O", "compartment": "c", "id": "dolichol_c"}, {"name": "Dolichol phosphate C15H27O4P", "notes": {"original_bigg_ids": ["dolp_c"]}, "charge": -2, "formula": "C15H27O4P", "compartment": "c", "id": "dolp_c"}, {"name": "Deoxyribose C5H10O4", "notes": {"original_bigg_ids": ["drib_c"]}, "charge": 0, "formula": "C5H10O4", "compartment": "c", "id": "drib_c"}, {"name": "L erythro 4 Hydroxyglutamate C5H8NO5", "notes": {"original_bigg_ids": ["e4hglu_c"]}, "charge": -1, "formula": "C5H8NO5", "compartment": "c", "id": "e4hglu_c"}, {"name": "Episterol C28H46O", "notes": {"original_bigg_ids": ["epist_c"]}, "charge": 0, "formula": "C28H46O", "compartment": "c", "id": "epist_c"}, {"name": "Episterol ester yeast specific C1695H2995O101", "notes": {"original_bigg_ids": ["epistest_SC_c"]}, "charge": 0, "formula": "C1695H2995O101", "compartment": "c", "id": "epistest_SC_c"}, {"name": "Epimelibiose C12H22O11", "notes": {"original_bigg_ids": ["epm_c"]}, "charge": 0, "formula": "C12H22O11", "compartment": "c", "id": "epm_c"}, {"name": "Ergosterol 3 beta D glucoside C34H54O6", "notes": {"original_bigg_ids": ["ergst3glc_c"]}, "charge": 0, "formula": "C34H54O6", "compartment": "c", "id": "ergst3glc_c"}, {"name": "Ergosterol C28H44O", "notes": {"original_bigg_ids": ["ergst_c"]}, "charge": 0, "formula": "C28H44O", "compartment": "c", "id": "ergst_c"}, {"name": "Ergosterol ester yeast specific C1695H2993O101", "notes": {"original_bigg_ids": ["ergstest_SC_c"]}, "charge": 0, "formula": "C1695H2993O101", "compartment": "c", "id": "ergstest_SC_c"}, {"name": "Ergosta 5 7 22 24 28 tetraen 3beta ol C28H42O", "notes": {"original_bigg_ids": ["ergtetrol_c"]}, "charge": 0, "formula": "C28H42O", "compartment": "c", "id": "ergtetrol_c"}, {"name": "Ergosta 5 7 24 28 trienol C28H44O", "notes": {"original_bigg_ids": ["ergtrol_c"]}, "charge": 0, "formula": "C28H44O", "compartment": "c", "id": "ergtrol_c"}, {"name": "D erythro Ascorbate C5H6O5", "notes": {"original_bigg_ids": ["ertascb_D_c"]}, "charge": 0, "formula": "C5H6O5", "compartment": "c", "id": "ertascb__D_c"}, {"name": "Ethanolamine phosphate C2H7NO4P", "notes": {"original_bigg_ids": ["ethamp_c"]}, "charge": -1, "formula": "C2H7NO4P", "compartment": "c", "id": "ethamp_c"}, {"name": "D Fructose 2 6 bisphosphate C6H10O12P2", "notes": {"original_bigg_ids": ["f26bp_c"]}, "charge": -4, "formula": "C6H10O12P2", "compartment": "c", "id": "f26bp_c"}, {"name": "Fecosterol C28H46O", "notes": {"original_bigg_ids": ["fecost_c"]}, "charge": 0, "formula": "C28H46O", "compartment": "c", "id": "fecost_c"}, {"name": "Fecosterol ester yeast specific C1695H2995O101", "notes": {"original_bigg_ids": ["fecostest_SC_c"]}, "charge": 0, "formula": "C1695H2995O101", "compartment": "c", "id": "fecostest_SC_c"}, {"name": "Beta D glucose 6 phosphate C6H11O9P", "notes": {"original_bigg_ids": ["g6p_B_c"]}, "charge": -2, "formula": "C6H11O9P", "compartment": "c", "id": "g6p_B_c"}, {"name": "Geranylgeranyl diphosphate C20H33O7P2", "notes": {"original_bigg_ids": ["ggdp_c"]}, "charge": -3, "formula": "C20H33O7P2", "compartment": "c", "id": "ggdp_c"}, {"name": "Galactosylglycerol C9H18O8", "notes": {"original_bigg_ids": ["ggl_c"]}, "charge": 0, "formula": "C9H18O8", "compartment": "c", "id": "ggl_c"}, {"name": "Glycylpeptide C4H7N2O3R", "notes": {"original_bigg_ids": ["glp_c"]}, "charge": 0, "formula": "C4H7N2O3R", "compartment": "c", "id": "glp_c"}, {"name": "5 L Glutamyl L alanine C8H13N2O5", "notes": {"original_bigg_ids": ["gluala_c"]}, "charge": -1, "formula": 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"indpyr_c"}, {"name": "Inositol phosphorylceramide ceramide 1 24C yeast specific C4800H9500N100O1100P100", "notes": {"original_bigg_ids": ["ipc124_SC_c"]}, "charge": -100, "formula": "C4800H9500N100O1100P100", "compartment": "c", "id": "ipc124_SC_c"}, {"name": "Inositol phosphorylceramide ceramide 1 26C yeast specific C5000H9900N100O1100P100", "notes": {"original_bigg_ids": ["ipc126_SC_c"]}, "charge": -100, "formula": "C5000H9900N100O1100P100", "compartment": "c", "id": "ipc126_SC_c"}, {"name": "Inositol phosphorylceramide ceramide 2 24C yeast specific C4800H9500N100O1200P100", "notes": {"original_bigg_ids": ["ipc224_SC_c"]}, "charge": -100, "formula": "C4800H9500N100O1200P100", "compartment": "c", "id": "ipc224_SC_c"}, {"name": "Inositol phosphorylceramide ceramide 2 26C yeast specific C5000H9900N100O1200P100", "notes": {"original_bigg_ids": ["ipc226_SC_c"]}, "charge": -100, "formula": "C5000H9900N100O1200P100", "compartment": "c", "id": "ipc226_SC_c"}, {"name": "Inositol 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