Hi,
Thank you for this nice tool! I am now working on multiple sections from different samples and cancer types. I noticed that you recommend the users to combine all samples into one single run (#6 ), but this is really not doable when the sample number comes to hundreds or thousands.
Besides, I saw LARIS is searching the nearest 20 neighborhoods (by default) for spatial analysis. However, when multiple sections were tiled, is that possible the cells on the edge of each section will be biased because the cells on the adjacent section might be mis-assigned as neighrborhoods?
I am not sure if we can run LARIS separately for each sample and then make comparisons using wilcox or other methods.
Thanks,
Yuwei
Hi,
Thank you for this nice tool! I am now working on multiple sections from different samples and cancer types. I noticed that you recommend the users to combine all samples into one single run (#6 ), but this is really not doable when the sample number comes to hundreds or thousands.
Besides, I saw LARIS is searching the nearest 20 neighborhoods (by default) for spatial analysis. However, when multiple sections were tiled, is that possible the cells on the edge of each section will be biased because the cells on the adjacent section might be mis-assigned as neighrborhoods?
I am not sure if we can run LARIS separately for each sample and then make comparisons using wilcox or other methods.
Thanks,
Yuwei