diff --git a/dev-packages/node-core-integration-tests/suites/cron/node-cron/scenario.ts b/dev-packages/node-core-integration-tests/suites/cron/node-cron/base/scenario.ts
similarity index 93%
rename from dev-packages/node-core-integration-tests/suites/cron/node-cron/scenario.ts
rename to dev-packages/node-core-integration-tests/suites/cron/node-cron/base/scenario.ts
index 818bf7b63871..0cfa7d79c135 100644
--- a/dev-packages/node-core-integration-tests/suites/cron/node-cron/scenario.ts
+++ b/dev-packages/node-core-integration-tests/suites/cron/node-cron/base/scenario.ts
@@ -1,7 +1,7 @@
 import * as Sentry from '@sentry/node-core';
 import { loggingTransport } from '@sentry-internal/node-integration-tests';
 import * as cron from 'node-cron';
-import { setupOtel } from '../../../utils/setupOtel';
+import { setupOtel } from '../../../../utils/setupOtel';
 
 const client = Sentry.init({
   dsn: 'https://public@dsn.ingest.sentry.io/1337',
diff --git a/dev-packages/node-core-integration-tests/suites/cron/node-cron/test.ts b/dev-packages/node-core-integration-tests/suites/cron/node-cron/base/test.ts
similarity index 96%
rename from dev-packages/node-core-integration-tests/suites/cron/node-cron/test.ts
rename to dev-packages/node-core-integration-tests/suites/cron/node-cron/base/test.ts
index dcdb1ba4c4d9..6935fb289b16 100644
--- a/dev-packages/node-core-integration-tests/suites/cron/node-cron/test.ts
+++ b/dev-packages/node-core-integration-tests/suites/cron/node-cron/base/test.ts
@@ -1,5 +1,5 @@
 import { afterAll, expect, test } from 'vitest';
-import { cleanupChildProcesses, createRunner } from '../../../utils/runner';
+import { cleanupChildProcesses, createRunner } from '../../../../utils/runner';
 
 afterAll(() => {
   cleanupChildProcesses();
diff --git a/dev-packages/node-core-integration-tests/suites/cron/node-cron/isolateTrace/scenario.ts b/dev-packages/node-core-integration-tests/suites/cron/node-cron/isolateTrace/scenario.ts
new file mode 100644
index 000000000000..e06814477bf5
--- /dev/null
+++ b/dev-packages/node-core-integration-tests/suites/cron/node-cron/isolateTrace/scenario.ts
@@ -0,0 +1,59 @@
+import * as Sentry from '@sentry/node-core';
+import { loggingTransport } from '@sentry-internal/node-integration-tests';
+import * as cron from 'node-cron';
+import { setupOtel } from '../../../../utils/setupOtel';
+
+const client = Sentry.init({
+  dsn: 'https://public@dsn.ingest.sentry.io/1337',
+  release: '1.0',
+  transport: loggingTransport,
+});
+
+setupOtel(client);
+
+const cronWithCheckIn = Sentry.cron.instrumentNodeCron(cron, { isolateTrace: true });
+
+let closeNext1 = false;
+let closeNext2 = false;
+
+const task = cronWithCheckIn.schedule(
+  '* * * * * *',
+  () => {
+    if (closeNext1) {
+      // https://github.com/node-cron/node-cron/issues/317
+      setImmediate(() => {
+        task.stop();
+      });
+
+      throw new Error('Error in cron job');
+    }
+
+    // eslint-disable-next-line no-console
+    console.log('You will see this message every second');
+    closeNext1 = true;
+  },
+  { name: 'my-cron-job' },
+);
+
+const task2 = cronWithCheckIn.schedule(
+  '* * * * * *',
+  () => {
+    if (closeNext2) {
+      // https://github.com/node-cron/node-cron/issues/317
+      setImmediate(() => {
+        task2.stop();
+      });
+
+      throw new Error('Error in cron job 2');
+    }
+
+    // eslint-disable-next-line no-console
+    console.log('You will see this message every second');
+    closeNext2 = true;
+  },
+  { name: 'my-2nd-cron-job' },
+);
+
+setTimeout(() => {
+  process.exit();
+}, 5000);
diff --git a/dev-packages/node-core-integration-tests/suites/cron/node-cron/isolateTrace/test.ts b/dev-packages/node-core-integration-tests/suites/cron/node-cron/isolateTrace/test.ts
new file mode 100644
index 000000000000..cf469d2e6acd
--- /dev/null
+++ b/dev-packages/node-core-integration-tests/suites/cron/node-cron/isolateTrace/test.ts
@@ -0,0 +1,49 @@
+import { afterAll, expect, test } from 'vitest';
+import { cleanupChildProcesses, createRunner } from '../../../../utils/runner';
+
+afterAll(() => {
+  cleanupChildProcesses();
+});
+
+test('node-cron instrumentation with isolateTrace creates distinct traces for each cron job', async () => {
+  let firstErrorTraceId: string | undefined;
+
+  await createRunner(__dirname, 'scenario.ts')
+    .ignore('check_in')
+    .expect({
+      event: event => {
+        const traceId = event.contexts?.trace?.trace_id;
+        const spanId = event.contexts?.trace?.span_id;
+
+        expect(traceId).toMatch(/[a-f\d]{32}/);
+        expect(spanId).toMatch(/[a-f\d]{16}/);
+
+        firstErrorTraceId = traceId;
+
+        expect(event.exception?.values?.[0]).toMatchObject({
+          type: 'Error',
+          value: expect.stringMatching(/^Error in cron job( 2)?$/),
+          mechanism: { type: 'auto.function.node-cron.instrumentNodeCron', handled: false },
+        });
+      },
+    })
+    .expect({
+      event: event => {
+        const traceId = event.contexts?.trace?.trace_id;
+        const spanId = event.contexts?.trace?.span_id;
+
+        expect(traceId).toMatch(/[a-f\d]{32}/);
+        expect(spanId).toMatch(/[a-f\d]{16}/);
+
+        expect(traceId).not.toBe(firstErrorTraceId);
+
+        expect(event.exception?.values?.[0]).toMatchObject({
+          type: 'Error',
+          value: expect.stringMatching(/^Error in cron job( 2)?$/),
+          mechanism: { type: 'auto.function.node-cron.instrumentNodeCron', handled: false },
+        });
+      },
+    })
+    .start()
+    .completed();
+});
diff --git a/packages/node-core/src/cron/node-cron.ts b/packages/node-core/src/cron/node-cron.ts
index a2374b06d4b5..2652cbaa8bc0 100644
--- a/packages/node-core/src/cron/node-cron.ts
+++ b/packages/node-core/src/cron/node-cron.ts
@@ -1,4 +1,4 @@
-import { captureException, withMonitor } from '@sentry/core';
+import { captureException, type MonitorConfig, withMonitor } from '@sentry/core';
 import { replaceCronNames } from './common';
 
 export interface NodeCronOptions {
@@ -28,7 +28,10 @@ export interface NodeCron {
  * );
  * ```
  */
-export function instrumentNodeCron<T>(lib: Partial<NodeCron> & T): T {
+export function instrumentNodeCron<T>(
+  lib: Partial<NodeCron> & T,
+  monitorConfig: Pick<MonitorConfig, 'isolateTrace'> = {},
+): T {
   return new Proxy(lib, {
     get(target, prop) {
       if (prop === 'schedule' && target.schedule) {
@@ -65,6 +68,7 @@ export function instrumentNodeCron<T>(lib: Partial<NodeCron> & T): T {
                 {
                   schedule: { type: 'crontab', value: replaceCronNames(expression) },
                   timezone,
+                  ...monitorConfig,
                 },
               );
             };