diff --git a/src/sentry/integrations/github/client.py b/src/sentry/integrations/github/client.py
index 4cd9ca12f27d55..a8b7d32a930c50 100644
--- a/src/sentry/integrations/github/client.py
+++ b/src/sentry/integrations/github/client.py
@@ -31,7 +31,12 @@
 from sentry.models.pullrequest import PullRequest, PullRequestComment
 from sentry.models.repository import Repository
 from sentry.shared_integrations.client.proxy import IntegrationProxyClient
-from sentry.shared_integrations.exceptions import ApiError, ApiRateLimitedError, UnknownHostError
+from sentry.shared_integrations.exceptions import (
+    ApiError,
+    ApiForbiddenError,
+    ApiRateLimitedError,
+    UnknownHostError,
+)
 from sentry.silo.base import control_silo_function
 from sentry.utils import metrics
 
@@ -41,6 +46,24 @@
 # as the lower ceiling before hitting Github anymore, thus, leaving at least these
 # many requests left for other features that need to reach Github
 MINIMUM_REQUESTS = 200
+_SECONDARY_RATE_LIMIT_PHRASE = "secondary rate limit"
+
+
+def _is_secondary_rate_limit_error(error: ApiForbiddenError) -> bool:
+    """
+    Detect GitHub "secondary rate limit" responses which are returned as HTTP 403s.
+    """
+
+    candidates: list[str] = []
+    if isinstance(getattr(error, "json", None), Mapping):
+        message = error.json.get("message")
+        if isinstance(message, str):
+            candidates.append(message)
+    if isinstance(error.text, str):
+        candidates.append(error.text)
+    combined = " ".join(candidates).lower()
+    return _SECONDARY_RATE_LIMIT_PHRASE in combined
+
 
 JWT_AUTH_ROUTES = ("/app/installations", "access_tokens")
 
@@ -670,6 +693,21 @@ def get_blame_for_files(
             except ValueError as e:
                 logger.exception(str(e), log_info)
                 return []
+            except ApiForbiddenError as e:
+                if _is_secondary_rate_limit_error(e):
+                    metrics.incr("integrations.github.get_blame_for_files.secondary_rate_limit")
+                    logger.warning(
+                        "sentry.integrations.github.get_blame_for_files.secondary_rate_limit",
+                        extra=log_info,
+                    )
+                    raise ApiRateLimitedError(
+                        e.text,
+                        code=e.code,
+                        url=e.url,
+                        host=e.host,
+                        path=e.path,
+                    ) from e
+                raise
             else:
                 self.set_cache(cache_key, response, 60)
 
diff --git a/tests/sentry/integrations/github/test_client.py b/tests/sentry/integrations/github/test_client.py
index a2be918f5e2a0f..ded7dcaeb1b01f 100644
--- a/tests/sentry/integrations/github/test_client.py
+++ b/tests/sentry/integrations/github/test_client.py
@@ -1752,6 +1752,49 @@ def test_rate_limit_exceeded(self, get_jwt, mock_logger_error) -> None:
             },
         )
 
+    @mock.patch("sentry.integrations.github.client.get_jwt", return_value="jwt_token_1")
+    @responses.activate
+    def test_secondary_rate_limit_treated_as_rate_limited(self, get_jwt) -> None:
+        responses.reset()
+        responses.add(
+            method=responses.POST,
+            url="https://api.github.com/app/installations/1/access_tokens",
+            body='{"token": "12345token", "expires_at": "2030-01-01T00:00:00Z"}',
+            status=200,
+            content_type="application/json",
+        )
+        responses.add(
+            method=responses.GET,
+            url="https://api.github.com/rate_limit",
+            body=orjson.dumps(
+                {
+                    "resources": {
+                        "graphql": {
+                            "limit": 5000,
+                            "used": 100,
+                            "remaining": 4000,
+                            "reset": 1613064000,
+                        }
+                    }
+                }
+            ).decode(),
+            status=200,
+            content_type="application/json",
+        )
+        responses.add(
+            method=responses.POST,
+            url="https://api.github.com/graphql",
+            json={
+                "message": "You have exceeded a secondary rate limit. Please wait a few minutes before you try again.",
+                "documentation_url": "https://docs.github.com/en/rest/overview/rate-limits-for-the-rest-api",
+            },
+            status=403,
+            content_type="application/json",
+        )
+
+        with pytest.raises(ApiRateLimitedError):
+            self.github_client.get_blame_for_files([self.file], extra={})
+
     @mock.patch("sentry.integrations.github.client.get_jwt", return_value="jwt_token_1")
     @responses.activate
     def test_no_rate_limiting(self, get_jwt) -> None: