diff --git a/docs/environment-variables.md b/docs/environment-variables.md
index a0a3cfd8cf5..f4a7411fe6d 100644
--- a/docs/environment-variables.md
+++ b/docs/environment-variables.md
@@ -287,3 +287,7 @@ those.
 - `GRAPH_ENABLE_SQL_QUERIES`: Enable the experimental [SQL query
   interface](implementation/sql-interface.md).
   (default: false)
+- `GRAPH_STORE_DISABLE_CALL_CACHE`: Disables the store call cache entirely. Graph node will skip writing and reading from the
+  call cache. The buffered block call cache will still be enabled. This option may be useful
+  for indexers who are running their own RPC nodes. Disabling the store call cache may have
+  significant performance impact. (default: false)
diff --git a/graph/src/env/mod.rs b/graph/src/env/mod.rs
index 3fce087986e..905907e39b9 100644
--- a/graph/src/env/mod.rs
+++ b/graph/src/env/mod.rs
@@ -25,6 +25,7 @@ lazy_static! {
 lazy_static! {
     pub static ref TEST_WITH_NO_REORG: Mutex<bool> = Mutex::new(false);
     pub static ref TEST_SQL_QUERIES_ENABLED: Mutex<bool> = Mutex::new(false);
+    pub static ref TEST_STORE_CALL_CACHE_DISABLED: Mutex<bool> = Mutex::new(false);
 }
 
 /// Panics if:
@@ -441,6 +442,25 @@ impl EnvVars {
         let mut lock = TEST_SQL_QUERIES_ENABLED.lock().unwrap();
         *lock = enable;
     }
+
+    #[cfg(debug_assertions)]
+    pub fn store_call_cache_disabled(&self) -> bool {
+        if *TEST_STORE_CALL_CACHE_DISABLED.lock().unwrap() {
+            true
+        } else {
+            self.store.disable_call_cache
+        }
+    }
+
+    #[cfg(not(debug_assertions))]
+    pub fn store_call_cache_disabled(&self) -> bool {
+        self.store.disable_call_cache
+    }
+
+    #[cfg(debug_assertions)]
+    pub fn set_store_call_cache_disabled_for_tests(&self, value: bool) {
+        *TEST_STORE_CALL_CACHE_DISABLED.lock().unwrap() = value;
+    }
 }
 
 impl Default for EnvVars {
diff --git a/graph/src/env/store.rs b/graph/src/env/store.rs
index e267b28d8ce..c6eb1a09427 100644
--- a/graph/src/env/store.rs
+++ b/graph/src/env/store.rs
@@ -149,6 +149,10 @@ pub struct EnvVarsStore {
     /// The number of rows to fetch from the foreign data wrapper in one go,
     /// this will be set as the option 'fetch_size' on all foreign servers
     pub fdw_fetch_size: usize,
+    /// Disables the store call cache entirely. Graph node will skip writing and reading from the
+    /// call cache. The buffered block call cache will still be enabled.
+    /// Set by `GRAPH_STORE_DISABLE_CALL_CACHE`. Defaults to false.
+    pub disable_call_cache: bool,
 }
 
 // This does not print any values avoid accidentally leaking any sensitive env vars
@@ -206,6 +210,7 @@ impl TryFrom<InnerStore> for EnvVarsStore {
             disable_block_cache_for_lookup: x.disable_block_cache_for_lookup,
             insert_extra_cols: x.insert_extra_cols,
             fdw_fetch_size: x.fdw_fetch_size,
+            disable_call_cache: x.disable_call_cache,
         };
         if let Some(timeout) = vars.batch_timeout {
             if timeout < 2 * vars.batch_target_duration {
@@ -295,6 +300,8 @@ pub struct InnerStore {
     insert_extra_cols: usize,
     #[envconfig(from = "GRAPH_STORE_FDW_FETCH_SIZE", default = "1000")]
     fdw_fetch_size: usize,
+    #[envconfig(from = "GRAPH_STORE_DISABLE_CALL_CACHE", default = "false")]
+    disable_call_cache: bool,
 }
 
 #[derive(Clone, Copy, Debug)]
diff --git a/store/postgres/src/chain_store.rs b/store/postgres/src/chain_store.rs
index e3ee70f378d..03cee52f0c7 100644
--- a/store/postgres/src/chain_store.rs
+++ b/store/postgres/src/chain_store.rs
@@ -2960,6 +2960,10 @@ impl EthereumCallCache for ChainStore {
         req: &call::Request,
         block: BlockPtr,
     ) -> Result<Option<call::Response>, Error> {
+        if ENV_VARS.store_call_cache_disabled() {
+            return Ok(None);
+        }
+
         let id = contract_call_id(req, &block);
         let conn = &mut *self.get_conn()?;
         let return_value = conn.transaction::<_, Error, _>(|conn| {
@@ -3036,6 +3040,10 @@ impl EthereumCallCache for ChainStore {
         block: BlockPtr,
         return_value: call::Retval,
     ) -> Result<(), Error> {
+        if ENV_VARS.store_call_cache_disabled() {
+            return Ok(());
+        }
+
         let return_value = match return_value {
             call::Retval::Value(return_value) if !return_value.is_empty() => return_value,
             _ => {
diff --git a/store/test-store/tests/postgres/chain_head.rs b/store/test-store/tests/postgres/chain_head.rs
index acc42ad1ee7..1cf89f45ac4 100644
--- a/store/test-store/tests/postgres/chain_head.rs
+++ b/store/test-store/tests/postgres/chain_head.rs
@@ -505,6 +505,36 @@ fn eth_call_cache() {
     })
 }
 
+#[test]
+fn test_disable_call_cache() {
+    let chain = vec![&*GENESIS_BLOCK, &*BLOCK_ONE, &*BLOCK_TWO];
+
+    run_test(chain, |store, _| {
+        ENV_VARS.set_store_call_cache_disabled_for_tests(true);
+
+        let logger = LOGGER.cheap_clone();
+        let address = H160([1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5]);
+        let call: [u8; 6] = [1, 2, 3, 4, 5, 6];
+        let return_value: [u8; 3] = [7, 8, 9];
+
+        let call = call::Request::new(address, call.to_vec(), 0);
+
+        store
+            .set_call(
+                &logger,
+                call.cheap_clone(),
+                BLOCK_ONE.block_ptr(),
+                call::Retval::Value(Bytes::from(return_value)),
+            )
+            .unwrap();
+
+        let ret = store.get_call(&call, BLOCK_ONE.block_ptr()).unwrap();
+
+        assert!(ret.is_none());
+        Ok(())
+    });
+}
+
 #[test]
 /// Tests mainly query correctness. Requires data in order not to hit early returns when no stale contracts are found.
 fn test_clear_stale_call_cache() {