Add Stressor-to-MIE Coverage Analysis

[marvinm2]

Description

Visualize how many stressors are linked to Molecular Initiating Events (MIEs) and how many MIEs have associated stressors. This reveals gaps in stressor annotation and helps identify which chemical/physical stressors trigger which molecular events - critical for risk assessment applications.

Visualization Types

• Latest snapshot: Current stressor-MIE linkage coverage
• Historical trends: Evolution of stressor annotations

Value & Priority

• Priority: Phase 3 - Lower Priority
• Value: Medium (specialized use case)
• Complexity: Low

Implementation Details

Key Data Requirements

• Query relationships between Stressors and MIEs
• Properties: has_molecular_initiating_event, Prototypical Stressors (C54571)
• Count:
  • Stressors per MIE
  • MIEs per stressor
  • Orphaned stressors (no MIE links)
  • Orphaned MIEs (no stressor links)

Visualization Format

• Matrix visualization: Stressors × MIEs showing linkage patterns
• Grouped bar chart: Distribution of linkage counts
• Gap analysis: Highlight orphaned stressors and MIEs
• Coverage metrics: Percentage of MIEs with stressor annotations

Expected Insights

• Identify gaps in stressor-to-pathway linkages
• Support chemical risk assessment by linking chemicals to biological effects
• Guide curation of stressor annotations
• Enable stressor-based pathway search
• Understand coverage of different stressor types (chemicals, physical, biological)

Performance Notes

• Simple relationship queries
• Low complexity
• May need to handle multiple stressor types per AOP