diff --git a/src/main/java/io/nats/streaming/StreamingConnectionImpl.java b/src/main/java/io/nats/streaming/StreamingConnectionImpl.java
index 6a410c2..1cf8242 100644
--- a/src/main/java/io/nats/streaming/StreamingConnectionImpl.java
+++ b/src/main/java/io/nats/streaming/StreamingConnectionImpl.java
@@ -354,7 +354,8 @@ void close(boolean silent) throws IOException, InterruptedException {
                     for (AckClosure ac : this.pubAckMap.values()) {
                         ac.ackTask.cancel();
 
-                        if (!ac.ch.isEmpty()) {
+                        // Note: Providing an Ack Handler when publishing to STAN (on Android) can result in NPEs during some closing scenarios
+                        if (ac.ch != null && !ac.ch.isEmpty()) {
                             ac.ch.take();
                         }
                     }