The OGC-NA maintains a register of GeoTIFF tags.
In the future it may be necessary for communities that use COG to register tags for their specialist use cases.
Such tags could then be organised into groups that deal with the needs of a particular domain.
See this OWS-9 engineering report for some examples of metadata for specialist use cases.
So the COG spec could include a mention of the GeoTIFF Tag Register.