The u-blox cellular module can work in tandem with a u-blox GPS module through the DDC pins (SDL and SDA, pins 26, 27). Can you consider making those pins available to the outside world through user pins? B0 and B1 seem convenient from the layout perspective.
It will make it easier to add an integrated GPS solution.
DDC pins allow -0.3 V to 3.6 V and are tristate without pull-up at reset so they wouldn't interfere with B0/B1 unless enabled through u-blox AT commands.
