diff --git a/pyodide_build/pywasmcross.py b/pyodide_build/pywasmcross.py
index 76ee51b8..7e1a65c0 100755
--- a/pyodide_build/pywasmcross.py
+++ b/pyodide_build/pywasmcross.py
@@ -83,11 +83,18 @@ def is_link_cmd(line: list[str]) -> bool:
     """
     Check if the command is a linker invocation.
     """
-    import re
-
-    SHAREDLIB_REGEX = re.compile(r"\.so(.\d+)*$")
     for arg in line:
-        if not arg.startswith("-") and SHAREDLIB_REGEX.search(arg):
+        parts = arg.split(".")
+        idx = len(parts) - 1
+
+        # response file
+        if parts[-1] == "rsp":
+            idx -= 1
+
+        while idx > 0 and parts[idx].isdigit():
+            idx -= 1
+
+        if idx > 0 and parts[idx] == "so":
             return True
 
     return False
diff --git a/pyodide_build/tests/test_pywasmcross.py b/pyodide_build/tests/test_pywasmcross.py
index 6b7381c2..9ceb8db1 100644
--- a/pyodide_build/tests/test_pywasmcross.py
+++ b/pyodide_build/tests/test_pywasmcross.py
@@ -266,4 +266,8 @@ def test_handle_command_cmake(build_args):
 def test_is_link_cmd():
     assert is_link_cmd(["test.so"])
     assert is_link_cmd(["test.so.1.2.3"])
+    assert is_link_cmd(["test.so.rsp"])
+    assert is_link_cmd(["test.1.2.3.so.rsp"])
+    assert not is_link_cmd(["test.1.2.3.rsp"])
+    assert is_link_cmd(["emcc.py", "test.so"])
     assert not is_link_cmd(["test", "test.a", "test.o", "test.c", "test.cpp", "test.h"])