diff --git a/Misc/NEWS.d/next/Library/2025-12-24-14-18-52.gh-issue-143145.eXLw8D.rst b/Misc/NEWS.d/next/Library/2025-12-24-14-18-52.gh-issue-143145.eXLw8D.rst
new file mode 100644
index 00000000000000..2aff1090b1812f
--- /dev/null
+++ b/Misc/NEWS.d/next/Library/2025-12-24-14-18-52.gh-issue-143145.eXLw8D.rst
@@ -0,0 +1 @@
+Fixed a possible reference leak in ctypes when constructing results with multiple output parameters on error.
diff --git a/Modules/_ctypes/_ctypes.c b/Modules/_ctypes/_ctypes.c
index bac119f2ae7a36..3d48c70bd0d227 100644
--- a/Modules/_ctypes/_ctypes.c
+++ b/Modules/_ctypes/_ctypes.c
@@ -4551,6 +4551,7 @@ _build_result(PyObject *result, PyObject *callargs,
             v = PyTuple_GET_ITEM(callargs, i);
             v = PyObject_CallMethodNoArgs(v, &_Py_ID(__ctypes_from_outparam__));
             if (v == NULL || numretvals == 1) {
+                Py_XDECREF(tup);
                 Py_DECREF(callargs);
                 return v;
             }