diff --git a/sub-packages/bionemo-noodles/Cargo.lock b/sub-packages/bionemo-noodles/Cargo.lock
index a482433..84a1f91 100644
--- a/sub-packages/bionemo-noodles/Cargo.lock
+++ b/sub-packages/bionemo-noodles/Cargo.lock
@@ -14,12 +14,6 @@ version = "1.4.0"
 source = "registry+https://github.com/rust-lang/crates.io-index"
 checksum = "ace50bade8e6234aa140d9a2f552bbee1db4d353f69b8217bc503490fc1a9f26"
 
-[[package]]
-name = "bitflags"
-version = "2.6.0"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "b048fb63fd8b5923fc5aa7b340d8e156aec7ec02f0c78fa8a6ddc2613f6f71de"
-
 [[package]]
 name = "bstr"
 version = "1.10.0"
@@ -82,11 +76,17 @@ dependencies = [
  "miniz_oxide",
 ]
 
+[[package]]
+name = "heck"
+version = "0.5.0"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "2304e00983f87ffb38b55b444b5e3b60a884b5d30c0fca7d82fe33449bbe55ea"
+
 [[package]]
 name = "indoc"
-version = "1.0.9"
+version = "2.0.6"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "bfa799dd5ed20a7e349f3b4639aa80d74549c81716d9ec4f994c9b5815598306"
+checksum = "f4c7245a08504955605670dbf141fceab975f15ca21570696aebe9d2e71576bd"
 
 [[package]]
 name = "libc"
@@ -94,16 +94,6 @@ version = "0.2.162"
 source = "registry+https://github.com/rust-lang/crates.io-index"
 checksum = "18d287de67fe55fd7e1581fe933d965a5a9477b38e949cfa9f8574ef01506398"
 
-[[package]]
-name = "lock_api"
-version = "0.4.12"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "07af8b9cdd281b7915f413fa73f29ebd5d55d0d3f0155584dade1ff18cea1b17"
-dependencies = [
- "autocfg",
- "scopeguard",
-]
-
 [[package]]
 name = "memchr"
 version = "2.7.4"
@@ -121,9 +111,9 @@ dependencies = [
 
 [[package]]
 name = "memoffset"
-version = "0.8.0"
+version = "0.9.1"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "d61c719bcfbcf5d62b3a09efa6088de8c54bc0bfcd3ea7ae39fcc186108b8de1"
+checksum = "488016bfae457b036d996092f6cb448677611ce4449e970ceaf42695203f218a"
 dependencies = [
  "autocfg",
 ]
@@ -188,27 +178,10 @@ source = "registry+https://github.com/rust-lang/crates.io-index"
 checksum = "1261fe7e33c73b354eab43b1273a57c8f967d0391e80353e51f764ac02cf6775"
 
 [[package]]
-name = "parking_lot"
-version = "0.12.3"
+name = "portable-atomic"
+version = "1.11.1"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "f1bf18183cf54e8d6059647fc3063646a1801cf30896933ec2311622cc4b9a27"
-dependencies = [
- "lock_api",
- "parking_lot_core",
-]
-
-[[package]]
-name = "parking_lot_core"
-version = "0.9.10"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "1e401f977ab385c9e4e3ab30627d6f26d00e2c73eef317493c4ec6d468726cf8"
-dependencies = [
- "cfg-if",
- "libc",
- "redox_syscall",
- "smallvec",
- "windows-targets",
-]
+checksum = "f84267b20a16ea918e43c6a88433c2d54fa145c92a811b5b047ccbe153674483"
 
 [[package]]
 name = "proc-macro2"
@@ -221,15 +194,16 @@ dependencies = [
 
 [[package]]
 name = "pyo3"
-version = "0.18.3"
+version = "0.24.1"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "e3b1ac5b3731ba34fdaa9785f8d74d17448cd18f30cf19e0c7e7b1fdb5272109"
+checksum = "17da310086b068fbdcefbba30aeb3721d5bb9af8db4987d6735b2183ca567229"
 dependencies = [
  "cfg-if",
  "indoc",
  "libc",
  "memoffset",
- "parking_lot",
+ "once_cell",
+ "portable-atomic",
  "pyo3-build-config",
  "pyo3-ffi",
  "pyo3-macros",
@@ -238,9 +212,9 @@ dependencies = [
 
 [[package]]
 name = "pyo3-build-config"
-version = "0.18.3"
+version = "0.24.1"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "9cb946f5ac61bb61a5014924910d936ebd2b23b705f7a4a3c40b05c720b079a3"
+checksum = "e27165889bd793000a098bb966adc4300c312497ea25cf7a690a9f0ac5aa5fc1"
 dependencies = [
  "once_cell",
  "target-lexicon",
@@ -248,9 +222,9 @@ dependencies = [
 
 [[package]]
 name = "pyo3-ffi"
-version = "0.18.3"
+version = "0.24.1"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "fd4d7c5337821916ea2a1d21d1092e8443cf34879e53a0ac653fbb98f44ff65c"
+checksum = "05280526e1dbf6b420062f3ef228b78c0c54ba94e157f5cb724a609d0f2faabc"
 dependencies = [
  "libc",
  "pyo3-build-config",
@@ -258,25 +232,27 @@ dependencies = [
 
 [[package]]
 name = "pyo3-macros"
-version = "0.18.3"
+version = "0.24.1"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "a9d39c55dab3fc5a4b25bbd1ac10a2da452c4aca13bb450f22818a002e29648d"
+checksum = "5c3ce5686aa4d3f63359a5100c62a127c9f15e8398e5fdeb5deef1fed5cd5f44"
 dependencies = [
  "proc-macro2",
  "pyo3-macros-backend",
  "quote",
- "syn 1.0.109",
+ "syn",
 ]
 
 [[package]]
 name = "pyo3-macros-backend"
-version = "0.18.3"
+version = "0.24.1"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "97daff08a4c48320587b5224cc98d609e3c27b6d437315bd40b605c98eeb5918"
+checksum = "f4cf6faa0cbfb0ed08e89beb8103ae9724eb4750e3a78084ba4017cbe94f3855"
 dependencies = [
+ "heck",
  "proc-macro2",
+ "pyo3-build-config",
  "quote",
- "syn 1.0.109",
+ "syn",
 ]
 
 [[package]]
@@ -288,21 +264,6 @@ dependencies = [
  "proc-macro2",
 ]
 
-[[package]]
-name = "redox_syscall"
-version = "0.5.7"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "9b6dfecf2c74bce2466cabf93f6664d6998a69eb21e39f4207930065b27b771f"
-dependencies = [
- "bitflags",
-]
-
-[[package]]
-name = "scopeguard"
-version = "1.2.0"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "94143f37725109f92c262ed2cf5e59bce7498c01bcc1502d7b9afe439a4e9f49"
-
 [[package]]
 name = "serde"
 version = "1.0.215"
@@ -320,24 +281,7 @@ checksum = "ad1e866f866923f252f05c889987993144fb74e722403468a4ebd70c3cd756c0"
 dependencies = [
  "proc-macro2",
  "quote",
- "syn 2.0.87",
-]
-
-[[package]]
-name = "smallvec"
-version = "1.13.2"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "3c5e1a9a646d36c3599cd173a41282daf47c44583ad367b8e6837255952e5c67"
-
-[[package]]
-name = "syn"
-version = "1.0.109"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "72b64191b275b66ffe2469e8af2c1cfe3bafa67b529ead792a6d0160888b4237"
-dependencies = [
- "proc-macro2",
- "quote",
- "unicode-ident",
+ "syn",
 ]
 
 [[package]]
@@ -353,9 +297,9 @@ dependencies = [
 
 [[package]]
 name = "target-lexicon"
-version = "0.12.16"
+version = "0.13.2"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "61c41af27dd6d1e27b1b16b489db798443478cef1f06a660c96db617ba5de3b1"
+checksum = "e502f78cdbb8ba4718f566c418c52bc729126ffd16baee5baa718cf25dd5a69a"
 
 [[package]]
 name = "unicode-ident"
@@ -365,70 +309,6 @@ checksum = "e91b56cd4cadaeb79bbf1a5645f6b4f8dc5bde8834ad5894a8db35fda9efa1fe"
 
 [[package]]
 name = "unindent"
-version = "0.1.11"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "e1766d682d402817b5ac4490b3c3002d91dfa0d22812f341609f97b08757359c"
-
-[[package]]
-name = "windows-targets"
-version = "0.52.6"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "9b724f72796e036ab90c1021d4780d4d3d648aca59e491e6b98e725b84e99973"
-dependencies = [
- "windows_aarch64_gnullvm",
- "windows_aarch64_msvc",
- "windows_i686_gnu",
- "windows_i686_gnullvm",
- "windows_i686_msvc",
- "windows_x86_64_gnu",
- "windows_x86_64_gnullvm",
- "windows_x86_64_msvc",
-]
-
-[[package]]
-name = "windows_aarch64_gnullvm"
-version = "0.52.6"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "32a4622180e7a0ec044bb555404c800bc9fd9ec262ec147edd5989ccd0c02cd3"
-
-[[package]]
-name = "windows_aarch64_msvc"
-version = "0.52.6"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "09ec2a7bb152e2252b53fa7803150007879548bc709c039df7627cabbd05d469"
-
-[[package]]
-name = "windows_i686_gnu"
-version = "0.52.6"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "8e9b5ad5ab802e97eb8e295ac6720e509ee4c243f69d781394014ebfe8bbfa0b"
-
-[[package]]
-name = "windows_i686_gnullvm"
-version = "0.52.6"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "0eee52d38c090b3caa76c563b86c3a4bd71ef1a819287c19d586d7334ae8ed66"
-
-[[package]]
-name = "windows_i686_msvc"
-version = "0.52.6"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "240948bc05c5e7c6dabba28bf89d89ffce3e303022809e73deaefe4f6ec56c66"
-
-[[package]]
-name = "windows_x86_64_gnu"
-version = "0.52.6"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "147a5c80aabfbf0c7d901cb5895d1de30ef2907eb21fbbab29ca94c5b08b1a78"
-
-[[package]]
-name = "windows_x86_64_gnullvm"
-version = "0.52.6"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "24d5b23dc417412679681396f2b49f3de8c1473deb516bd34410872eff51ed0d"
-
-[[package]]
-name = "windows_x86_64_msvc"
-version = "0.52.6"
+version = "0.2.4"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "589f6da84c646204747d1270a2a5661ea66ed1cced2631d546fdfb155959f9ec"
+checksum = "7264e107f553ccae879d21fbea1d6724ac785e8c3bfc762137959b5802826ef3"
diff --git a/sub-packages/bionemo-noodles/Cargo.toml b/sub-packages/bionemo-noodles/Cargo.toml
index b18dc57..4a3937c 100644
--- a/sub-packages/bionemo-noodles/Cargo.toml
+++ b/sub-packages/bionemo-noodles/Cargo.toml
@@ -9,7 +9,7 @@ name = "noodles_fasta_wrapper"  # The name of the library
 path = "rust/src/lib.rs"        # Path to the library file
 
 [dependencies]
-pyo3 = { version = "0.18", features = ["extension-module"] }
+pyo3 = { version = "0.24", features = ["extension-module"] }
 noodles-fasta = "0.45.0"  # Update to the latest version of noodles
 noodles-core = "*"
 memmap2 = "*"