Running multiple pipelines, or a long sequence of processes, will create a lot of intermediary files. This will not work on clusters, where we already have problems (tractflow+rbx+qc on both for 700 subjects doesn't work).
We'll have to either let go of resume, or use a strategy to lower the number of files and their sizes. This blog post describes a way to reduce file size in the work directory.
Note however that Nextflow is working on this problem right now : nextflow-io/nextflow#3849