Utilize phylogenetic approaches to evolutionary biology by treating chemical degradation pathways akin to mutational trees, enabling more sophisticated prediction of stability under diverse conditions. By constructing a 'degradation tree,' we can identify conserved pathways of molecule breakdown and simulate potential 'mutations' in formulation that could lead to stability improvements, borrowing methods such as maximum likelihood estimation commonly used in evolutionary rate studies.
Utilize phylogenetic approaches to evolutionary biology by treating chemical degradation pathways akin to mutational trees, enabling more sophisticated prediction of stability under diverse conditions. By constructing a 'degradation tree,' we can identify conserved pathways of molecule breakdown and simulate potential 'mutations' in formulation that could lead to stability improvements, borrowing methods such as maximum likelihood estimation commonly used in evolutionary rate studies.