Usage of Spatial information

[manfeiXie]

Dear Authors,

Thanks for your great work!
May I confirm whether it is correct to say that, in your tool, spatial information (cell coordinates) is used only to define cellular microenvironments and is not used in any other part of the tool to determine the cell-cell communication? This understanding is based on your description that “CellPhoneDB v5 can use spatial transcriptomics to restrict the analyses to those cell-type pairs coexisting in time and space in a tissue microenvironment, thereby reducing the number of predicted interactions to those occurring between neighboring cells (Fig. 3a). Spatial microenvironments can be defined from …”. Many thanks.