diff --git a/volatility3/framework/automagic/symbol_cache.py b/volatility3/framework/automagic/symbol_cache.py
index 22f1c94f34..5541d552eb 100644
--- a/volatility3/framework/automagic/symbol_cache.py
+++ b/volatility3/framework/automagic/symbol_cache.py
@@ -312,11 +312,18 @@ def update(self, progress_callback=None):
 
         # Missing entries
         if missing_locations:
-            self._database.cursor().execute(
-                f"DELETE FROM cache WHERE location IN ({','.join(['?'] * len(missing_locations))})",
-                [x for x in missing_locations],
-            )
-            self._database.commit()
+            for missing_location in missing_locations:
+                parsed_url = urllib.parse(missing_location)
+                if (
+                    parsed_url.scheme == "file"
+                    and parsed_url.host == ""
+                    and not os.path.exists(parsed_url.path)
+                ):
+                    self._database.cursor().execute(
+                        f"DELETE FROM cache WHERE location IN ({','.join(['?'] * len(missing_locations))})",
+                        [x for x in missing_locations],
+                    )
+                    self._database.commit()
 
         cache_update = set()
         files_to_timestamp = on_disk_locations.intersection(cached_locations)