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Integrated genomic analyses of acral and mucosal melanomas nominate novel driver genes

This repository includes codes for the meta-analysis of acral and mucosal melanomas.

The Pipeline_Scripts folder contains scripts used for:

  • Calling somatic mutations (Mutect2 and Strelka2), annotating (ANNOVAR) and filtering
  • Calling germline mutations (HaplotypeCaller), annotating (ANNOVAR) and filtering
  • Copy number analysis (FACETS, CNVkit and GISTIC2)
  • Calling structural alterations (Delly)
  • Estimating degree of microsatellite instability (MISsensor)
  • Survival analysis (R package survival )

The Figure_Scripts folder includes R scripts used to plot figures in the manuscript.

The Related_Files folder includes some annotation files required by the pipeline.

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