SpectralBio v1.2.0 - Claw4S 2026 Public Audit Release

SpectralBio v1.2.0 is the updated public audit release for the Claw4S 2026 submission.

Highlights

• BRCA2 is now the manuscript-facing flagship result with covariance-aware augmentation over a five-model ESM-1v baseline.
• TP53 remains the only frozen public canonical replay surface.
• The support-ranked top-25 feasible panel, protocol sweep, and BRCA1 failure analysis are exposed as public audit surfaces.
• Public links are pinned to the v1.2.0 tag tree.
• The release bundle has been resynced with the final paper, notebooks, SKILL, and publication mirrors.

Flagship scientific audit metrics

• BRCA2 ESM-1v baseline AUC: 0.6324
• BRCA2 covariance + ESM-1v AUC: 0.6890
• BRCA2 paired gain: 0.0566
• BRCA2 paired 95% bootstrap CI: [0.0131, 0.1063]
• BRCA2 empirical permutation p: 0.0010

Executable contract metrics

• TP53 canonical pair AUC: 0.7498
• BRCA1 transfer100 ll_proper AUC: 0.9174
• Reproducibility delta: 0.0

Validation summary

• pytest: PASS (39 passed)
• scripts/preflight.py: PASS

Artifact surfaces

• Paper PDF: paper/spectralbio.pdf
• Frozen release bundle: artifacts/release/claw4s_2026/
• Agent execution surface: SKILL.md

SpectralBio v1.1.0 - Claw4S 2026 Final Artifact

SpectralBio v1.1.0 is the finalized public artifact release for the Claw4S Conference 2026 submission.

Highlights

• Competition-grade public README with explicit Claw4S framing, authorship, paper context, and agent navigation.
• Canonical package surface under src/spectralbio with uv-first execution.
• TP53 canonical executable benchmark preserved as the primary scored path.
• BRCA1 fixed-subset bounded transfer evaluation preserved as secondary evidence without retraining.
• Frozen expected contracts, outputs, release bundle, and publication surfaces.
• Release validation passed with pytest, spectralbio verify, scripts/preflight.py, and spectralbio release.

Canonical quickstart

• python -m pip install uv
• uv sync --frozen
• uv run spectralbio canonical

Validation summary

• pytest: PASS (37 passed)
• spectralbio verify: PASS
• scripts/preflight.py: PASS
• spectralbio release: PASS

Artifact surfaces

• Paper: paper/spectralbio.pdf
• Frozen release bundle: artifacts/release/claw4s_2026/
• Agent execution surface: SKILL.md

SpectralBio v1.0 - Claw4S 2026 Submission

SpectralBio v1.0\n\nZero-shot variant pathogenicity prediction via spectral covariance analysis of ESM2 hidden states.\n\n### Key Results\n- TP53 (N=255): AUC = 0.7498 (best pair: 0.55frob_dist + 0.45ll_proper)\n- BRCA1 transfer (N=100): AUC = 0.9174 (ll_proper)\n- Reproducibility delta: 0.0\n\n### Links\n- Demo: https://huggingface.co/spaces/DaviBonetto/spectralbio-demo\n- Dataset: https://huggingface.co/datasets/DaviBonetto/spectralbio-clinvar\n- Paper (repo): https://github.com/DaviBonetto/SpectralBio/tree/main/paper\n