Minarose M Ismail, Davide Momi, Zheng Wang, Sorenza P. Bastiaens, M. Parsa Oveisi, Hansel M. Greiner, John D. Griffiths, Darren S. Kadis
Affiliations
- Department of Physiology, University of Toronto
- Neurosciences & Mental Health, The Hospital for Sick Children, Toronto
- Krembil Centre for Neuroinformatics, Centre for Addiction and Mental Health, Toronto
- Institute of Medical Sciences, University of Toronto
- Department of Psychiatry, University of Toronto
- Department of Pediatrics, College of Medicine, University of Cincinnati
This repository contains the complete code for the study:
"Development of Inhibitory Circuits Drives Language Lateralization in Childhood"
Ismail et al., 2025
In this study, we explore the mechanisms underlying language lateralization in childhood using personalized whole-brain network models. Our findings reveal that interhemispheric inhibitory circuits play a crucial role in shaping lateralized language function, with local inhibition decreasing over development while interhemispheric inhibition increases.
Using systematic model manipulations and virtual transplant experiments, we show that the reduction in local inhibition allows pre-existing asymmetries in interhemispheric inhibition to drive laterality. This work provides a developmental framework for understanding how inhibitory circuits shape language networks.
├── Code/ # preprocessing, modelling, analysis & simulation scripts
├── Figures/ # Figures in the paper
├── README.md # This file
The dataset used in this study is not publicly available due to institutional and ethical restrictions.
Coming soon ...hopefully
For inquiries, feel free to open an issue or contact:
- 📧 Minarose Ismail: minarose.ismail@mail.utoronto.ca