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# RNAPro: An accurate RNA structure prediction model by Kaggle synthesis

### Model Description
RNAPro is a state-of-the-art RNA 3D folding model developed in collaboration with the hosts and winners of the [Stanford RNA 3D Folding Kaggle competition.
](https://www.kaggle.com/competitions/stanford-rna-3d-folding) The model incorporates RNA-specific modules — including template modeling, multiple sequence alignment (MSA), and a pretrained RNA language model — to enhance RNA structure prediction performance. Read more about the kaggle competition and model in the [preprint](https://www.biorxiv.org/content/10.64898/2025.12.30.696949v1).
RNAPro is a state-of-the-art RNA 3D folding model developed in collaboration with the hosts and winners of the [Stanford RNA 3D Folding Kaggle competition.](https://www.kaggle.com/competitions/stanford-rna-3d-folding) RNAPro combines RNA-specific modules including template modeling, multiple sequence alignment (MSA), and a pretrained RNA foundation model, especially, RibonanzaNet2 with Protenix to enhance RNA structure prediction performance. Read more about the kaggle competition and model in the [preprint](https://www.biorxiv.org/content/10.64898/2025.12.30.696949v1).


## Installation
Expand Down Expand Up @@ -38,7 +37,6 @@ Run step 1., and inside the container, run step 3.
For more detailed instruction steps, check the [<u>Docker Installation</u>](docs/docker_installation.md) guide.



## Train Models

### 1. Data preparation
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Copyright (c) 2026 NVIDIA CORPORATION & AFFILIATES. All rights reserved.<br>
The source code is made available under Apache-2.0.<br>
The model weights are made available under the [NVIDIA Open Model License](https://www.nvidia.com/en-us/agreements/enterprise-software/nvidia-open-model-license/).
The model weights are made available under the [NVIDIA Open Model License](https://www.nvidia.com/en-us/agreements/enterprise-software/nvidia-open-model-license/).