Whole-body PBPK model of methotrexate as substrate of the breast cancer resistance protein (BCRP) transport protein and the victim drug for Drug-Drug-Interaction (DDI) simulations.
The presented PBPK model of methotrexate has been developed to be used in a PBPK Drug-Drug-Interactions (DDI) network with methotrexate as victim drug of BCRP. The development of this model is described in the publication by Schaller et al. [1]
- a PK-Sim project file of the current PBPK model
- a PK-Sim snapshot (*.json) file of the current PBPK model
PK-Sim Version 9.1
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The model code is distributed under the GPLv2 License.
[1] Schaller, S., Michon, I., Baier, V. et al. Evaluation of BCRP-Related DDIs Between Methotrexate and Cyclosporin A Using Physiologically Based Pharmacokinetic Modelling. Drugs R D (2024). https://doi.org/10.1007/s40268-024-00495-1