EV_DMS_Comparison

Files and code for: "Comparative Analysis of Deep Mutational Scanning Datasets of Enteroviruses A and B Identifies Functional Constraints and Therapeutic Targets". Álvarez-Rodríguez, Bakhache, McCormick, Geller, and Dolan. (2025)

Outline of Contents:

1. normalized_DMS_datasets

• EVA71
• CVB3

2. per_protein_corrected_data

• EVA71
• CVB3

3. protein_structures

• EVA71
• CVB3
• PV1
• EVD68 Predicted GBF1 interactions/membrane binding

4. alignments

• EVA71s
• CVB3s
• EVAs
• EVBs
• EVCs
• EVDs

5. site_data_master_tables

• master tables
• outer surface capsid
• entropy

6. phydms_results

• amino acid preferences at the type/species levels for EVA71 and CVB3

7. sitemap_results

• EVA71
• CVB3
• PV1
• EVD68