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Merged
xueweic merged 2 commits into from
Apr 21, 2025
Merged

minor fix format #68

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Update LD_Free_Colocalization.Rmd
xueweic Apr 21, 2025
8dffa7e
Merge branch 'StatFunGen:main' into main
xueweic Apr 21, 2025
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2 changes: 2 additions & 0 deletions vignettes/LD_Free_Colocalization.Rmd
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Expand Up @@ -34,6 +34,7 @@ An inaccurate LD matrix may lead to unreliable colocalization results, especiall
### Why LD Mismatch Matters

An inaccurate LD matrix can cause inconsistencies between the summary statistics and the reference LD matrix, leading to:

- Biased estimates of causal variants.
- Increased computational time due to slower algorithm convergence.
- Potentially misleading colocalization results.
Expand Down Expand Up @@ -93,6 +94,7 @@ To address these challenges, ColocBoost provides two alternative approaches for
with the assumption of one causal variant per trait per region:

- **One iteration approach** (recommended): performing only 1 iteration of gradient boosting with the LD matrix ensures that:

- The LD matrix is only used to check the equivalence among trait-specific best update variants.
- The accuracy of the results is improved compared to completely ignoring the LD matrix.

Expand Down