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@Hoeze Hoeze commented Mar 24, 2021

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for key, intervals in self.interval_fetcher:
intervals.sort(key=lambda x: x.start)
# Fetch variants corresponding to the intervals
intervals_with_variants = [(interval, self.variant_source.fetch_variants(interval))
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This is a very slow way to match variants. A better approach will be overlapping with pyranges if the variant strategy is single variant.

https://github.com/kipoi/kipoiseq/blob/master/kipoiseq/extractors/vcf_matching.py#L148

@MuhammedHasan
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As general, those classes are a good idea. They combine small building block extractors into dataloader in a generic way.

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3 participants