Given 1) a protein interaction network, with interfaces resolved and 2) Copy numbers for some of the proteins, Quantify degree of stoichiometric balance in protein copy numbers.
Also requires a distribution of protein copy numbers for the organism, to sample 'random' copy numbers for each protein and establish the significance of the observed copy numbers. Distributions available for yeast and human copy numbers.
C++ code
Note: In this directory, we have also provided the formatted model for the Clathrin vesicle system: ClathrinModule.bngl is provided in BioNetGen Language. Model description in the publication: http://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1006022#abstract0