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Evolution, diversity and function of the enzymes in the alpha-aminoadipate pathway across the fungal kingdom

Protein trees

• BUSCO protein tree

• The AAA pathway protein tree

• LYS20

• ACO2

• LYS4

• LYS12

• ARO8

• LYS2

• LYS9

• LYS1

Conservation of AAA pathway enzymes

Alpha-aminoadipate pathway enzymes of fungi representatives, with coloring - how conserved the amino acids are conserved across the fungal kingdom.

View interactive protein structure visualization

Conservation scores for alpha-aminoadipate pathway enzymes across the fungal kingdom. Trimmed alignment - removed gappy regions from the alignment.

View interactive conservation plots

ESM-C embedding projections of the AAA pathway enzymes

UMAP projections of enzyme ESM-C embeddings using cosine similarity as a distance metric

UMAP projections colored by phyla

UMAP projections colored by localization

Comparison of ESM-C and evolutionary distances

BUSCO phylogeny and the AAA pathway phylogeny distance comparison by phyla pairs

View pairwise phylogeny comparisons

Distance distribution histograms of ESM-C embedding distances and evolutionary distances for the AAA pathway enzymes

View interactive historgams