feat(rvdna): add health biomarker analysis engine with streaming simulation#199

Merged

ruvnet merged 13 commits intomainfrom

claude/health-biomarker-adr-ESZy4

Feb 22, 2026

Commits on Feb 22, 2026

feat(rvdna): add health biomarker analysis engine with streaming simulation
claude
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style(rvdna): apply linter formatting to biomarker module
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perf(rvdna): optimize biomarker engine — fix bug, reduce allocations, halve ring buffer memory
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refine(rvdna): calibrate biomarker weights and ranges from Genetic Lifehacks clinical data
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refine(rvdna): calibrate SNP weights from SOTA clinical meta-analyses
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feat(rvdna): add gene-biomarker correlations, CUSUM changepoint detection, and interaction tests
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docs: update rvDNA and root READMEs with health biomarker engine
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refactor(rvdna): consolidate SNP arrays, cache metadata, optimize streaming
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feat(rvdna): add LPA cardiovascular SNPs from SOTA meta-analysis evidence
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feat(rvdna): add PCSK9 rs11591147 protective cardiovascular SNP
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docs(rvdna): update README for 20-SNP panel with LPA and PCSK9
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feat(rvdna): add npm biomarker engine with risk scoring, streaming, and benchmarks
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perf(rvdna): optimize hot paths and add real-data integration tests
claude
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