Forensic RNA-seq re-analysis of dataset GSE286438 to audit EGCG-mediated senescence reversal claims using PyDESeq2, PCA, correlation matrices, and biomarker validation.
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Updated
Dec 24, 2025 - Jupyter Notebook
Forensic RNA-seq re-analysis of dataset GSE286438 to audit EGCG-mediated senescence reversal claims using PyDESeq2, PCA, correlation matrices, and biomarker validation.
It includes the figure depicting SASP heterogeneity in WI‑38 fibroblasts and per‑tissue differential expression results (senescent/stressed vs. control fibroblasts) derived from our ensemble-of-gene-sets (EGS) SASP scoring workflow.
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